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https://www.readbyqxmd.com/read/27487507/safety-of-the-long-term-application-of-quikclot-combat-gauze-chitogauze-pro-and-celox-gauze-in-a-femoral-artery-injury-model-in-swine-a-preliminary-study
#1
I Otrocka-Domagała, P Jastrzębski, Z Adamiak, K Paździor-Czapula, M Gesek, M Mikiewicz, T Rotkiewicz
The purpose of this study was to examine the safety of the long-term application of QuikClot Combat Gauze, ChitoGauze PRO and Celox Gauze using a swine model. The study was conducted on nine pigs weighing approximately 30 kg, which were randomly divided into three groups. Under deep anesthesia, the pigs underwent complete transverse cutting of the femoral artery in the groin region. Hemostatic dressings were left in the wound for 24 hours. The animals were euthanized 24 hours after dressing application. In each group, macroscopic and microscopic severe changes and shock symptoms were observed in the lungs, liver, kidneys and heart...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/26593785/polystat-modified-chitosan-gauzes-for-improved-hemostasis-in-external-hemorrhage
#2
Leslie W Chan, Chae Hwa Kim, Xu Wang, Suzie H Pun, Nathan J White, Tae Hee Kim
UNLABELLED: Positively-charged chitosan gauzes stop bleeding from wounds by electrostatically interacting with negatively-charged cell membranes of erythrocytes to cause erythrocyte agglutination and by sealing wounds through tissue adhesion. In the following work, nonwoven chitosan gauze was impregnated with PolySTAT, a synthetic polymer that enhances coagulation by cross-linking fibrin, to generate PolySTAT/chitosan gauzes with improved hemostatic efficacy. When comparing nonwoven chitosan and PolySTAT/chitosan to a commercially-available chitosan-containing gauze (Celox® Rapid), no appreciable differences were observed in fiber size, morphology, and pore size...
February 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26540712/control-of-junctional-hemorrhage-in-a-consensus-swine-model-with-hemostatic-gauze-products-following-minimal-training
#3
Sean P Conley, Lanny F Littlejohn, Jose Henao, Sara S DeVito, Gregory J Zarow
OBJECTIVE: Uncontrolled hemorrhage from junctional wounds that cannot be controlled by traditional tourniquets accounts for one in five preventable battlefield exsanguination deaths. Products for treating these wounds are costly and require special training. However, chemically treated gauze products are inexpensive, potentially effective, and require only minimal training. This study was designed to assess the efficacy of three hemostatic gauze products following brief training, using a consensus swine groin injury model...
November 2015: Military Medicine
https://www.readbyqxmd.com/read/26490559/comparison-of-the-efficacy-and-histopathological-effects-of-three-hemostatic-agents-in-a-partial-nephrectomy-rat-model
#4
COMPARATIVE STUDY
Mehmet Ozgur Yucel, Haci Polat, Murat Bagcioglu, Tolga Karakan, Can Benlioglu, Ali Cift, Alper Gok, Hesna Muzeyyen Astarci, Turgay Akgul, Cankon Germiyanoglu
PURPOSE: The major complications of partial nephrectomy are bleeding and urine leakage. While various hemostatic agents are used to control bleeding, the histopathological characteristics of these hemostatic agents have not been investigated adequately. We aimed to investigate and compare the histopathological and hemostatic effects of local hemostatic agents in a partial nephrectomy rat model. METHODS: Thirty-two rats were divided into four equal groups, and partial nephrectomy was done to all rats...
January 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/25913214/comparison-of-the-efficiencies-of-buffers-containing-ankaferd-and-chitosan-on-hemostasis-in-an-experimental-rat-model-with-femoral-artery-bleeding
#5
Serkan Abacıoğlu, Kemal Aydın, Fatih Büyükcam, Ural Kaya, Bahattin Işık, Muhammed Evvah Karakılıç
OBJECTIVE: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper® and a chitosan linear polymer (Celox®) in an experimental rat model with femoral artery bleeding. MATERIALS AND METHODS: Thirty male Wistar albino rats weighing 200-250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision...
March 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/25825701/celox-coated-gauze-for-the-treatment-of-civilian-penetrating-trauma-a-randomized-clinical-trial
#6
Hamid Reza Hatamabadi, Fatemeh Asayesh Zarchi, Hamid Kariman, Ali Arhami Dolatabadi, Ali Tabatabaey, Afshin Amini
BACKGROUND: Uncontrolled hemorrhage is a well-recognized cause of mortality in trauma victims and the control of active hemorrhage is among the initial steps in resuscitation. OBJECTIVES: The purpose of this study was to assess the role of a hemostatic agent "celox" in the management of civilian stab-wound trauma. PATIENTS AND METHODS: In this clinical trial study, 160 patients with penetrating limb trauma were randomly allocated to either the control or intervention group (n = 80, each group)...
February 2015: Trauma Monthly
https://www.readbyqxmd.com/read/25784969/topical-and-effective-hemostatic-medicines-in-the-battlefield
#7
REVIEW
Yin-Juan Zhang, Bo Gao, Xi-Wen Liu
Uncontrolled hemorrhage has been considered as one of the most important factors for causing death on the battlefront. If given timely and efficient hemostatic medicines in pre-hospital setting, patients will obtain more time and chance to wait for medical treatment so as to save their lives. However, there is not a certain answer about which kind of hemostatic drugs can achieve efficacious effect to hemostasis in the battle. This review aims to summarize effective hemostatic medicines applied in battlefield from 41 articles...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25638989/response-of-the-coagulation-system-after-application-of-hemostatic-dressings-in-an-animal-model
#8
P Jastrzębski, Z Adamiak, A Pomianowski, W Krystkiewicz, P Holak, S Sawicki, P Przyborowska, Y Zhalniarovich, G Gudzbeler
The objective of this study was to determine the response of hemostatic dressings. Coagulation and fibrinolytic systems, red blood cell parameters, platelet and leukocyte counts were evaluated after the application of hemostatic dressings: QuikClot, Chitoauze and Celox gauze. The experiment was performed on ten pigs.
2014: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/25344707/management-of-external-hemorrhage-in-tactical-combat-casualty-care-chitosan-based-hemostatic-gauze-dressings-tccc-guidelines-change-13-05
#9
Brad L Bennett, Lanny F Littlejohn, Bijan S Kheirabadi, Frank K Butler, Russ S Kotwal, Michael A Dubick, Jeffrey A Bailey
Hemorrhage remains the leading cause of combat death and a major cause of death from potentially survivable injuries. Great strides have been made in controlling extremity hemorrhage with tourniquets, but not all injuries are amenable to tourniquet application. Topical hemostatic agents and dressings have also contributed to success in controlling extremity and compressible junctional hemorrhage, and their efficacy continues to increase as enhanced products are developed. Since the addition of Combat Gauze™ (Z-Medica Corporation, Wallingford, CT, USA; http://www...
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/25286664/effect-of-24-hour-application-of-three-hemostatic-dressings-to-porcine-thigh-muscles
#10
Z Adamiak, P Jastrzebski, A Pomianowski, I Otrocka-Domagała, P Holak, Y Zhalniarovich, P Przyborowska, J Głodek
The effectiveness of three types of hemostatic dressings, QuikClot Gauze, ChitoGauze PRO and Celox Gauze, was evaluated in nine pigs. The results indicated a strong influence of all examined dressings on porcine femoral muscle tissue evaluated 24 hours after direct contact. A histopathological analysis revealed pathological changes in muscle tissue specimens collected from all the animals.
2014: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/25214235/concurrent-changes-in-methyl-jasmonate-emission-and-the-expression-of-its-biosynthesis-related-genes-in-cymbidium-ensifolium-flowers
#11
Mingkun Huang, Cuiping Ma, Rangcai Yu, Lanling Mu, Jia Hou, Yunyi Yu, Yanping Fan
Methyl jasmonate (MeJA) is one of most abundant scent compounds in Cymbidium ensifolium flowers. In this study, the emission of MeJA and its regulation mechanism were investigated. Our results showed that emission of MeJA in C. ensifolium flowers was controlled developmentally and rhythmically. It occurred in a tissue-specific manner, and high MeJA emission was found in sepals and petals. A group of vital genes involved in the MeJA biosynthesis via the octadecanoid pathway were isolated from C. ensifolium flowers, including CeLOX, CeAOS, CeAOC and CeJMT...
April 2015: Physiologia Plantarum
https://www.readbyqxmd.com/read/24806495/review-of-new-topical-hemostatic-dressings-for-combat-casualty-care
#12
REVIEW
Brad L Bennett, Lanny Littlejohn
This review analyzes the new (2008-2013) hemostatic agents and dressings for enhanced efficacy in preclinical studies, and investigates supportive findings among case reports of effectiveness and safety in hospital and prehospital literature. A literature search was conducted using PubMed, National Library of Medicine using key words and phrases. The search revealed a total of 16 articles that fit the criteria established for third-generation hemostatic dressings. There were a total of 9 preclinical, 5 clinical, and 2 prehospital studies evaluated...
May 2014: Military Medicine
https://www.readbyqxmd.com/read/24611305/-the-use-of-local-hemostatic-agent-celox-in-experimental-model-of-grade-iv-liver-injury
#13
I M Samokhvalov, K P Golovko, V A Reva, A V Zhabin, A V Denisov, M V Sokhranov, M V Kaznacheev, A B Iudin, P G Alisov
Ongoing intra-abdominal bleeding is the main life-threatening sequence of blunt abdominal trauma. The use of local hemostatic agents allows achieving fast and reliable hemorrhage control in case of parenchymatous organs injury. We investigated the efficacy of a dressing "Celox Gauze" in an experimental model of grade IV liver injury in large animals in the setting of coagulopathy. We used the following experimental model: 30-35% of blood volume was withdrawn followed by severe liver injury and hemostatic agent application...
November 2013: Voenno-medit︠s︡inskiĭ Zhurnal
https://www.readbyqxmd.com/read/24059601/successful-use-of-a-military-grade-haemostatic-agent-for-a-major-head-and-neck-bleed
#14
R Crunkhorn, R Burnham, G Walton
BACKGROUND: Major haemorrhage is a catastrophic complication occurring in 3-4 per cent of head and neck cancer patients. Massive haemorrhage also causes 50 per cent of preventable deaths in combat situations. There has been a surge of interest in the development of effective haemostatic products in the military, with chitosan being one such product. CASE REPORT: A 48-year-old lady presented with a life-threatening head and neck bleed. She was known to have a malignant peripheral nerve sheath sarcoma originating from the left parapharyngeal space...
October 2013: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/23883900/comparison-of-novel-hemostatic-dressings-with-quikclot-combat-gauze-in-a-standardized-swine-model-of-uncontrolled-hemorrhage
#15
COMPARATIVE STUDY
Jason M Rall, Jennifer M Cox, Adam G Songer, Ramon F Cestero, James D Ross
BACKGROUND: Uncontrolled hemorrhage is the leading cause of preventable death on the battlefield. The development, testing, and application of novel hemostatic dressings may lead to a reduction of prehospital mortality through enhanced point-of-injury hemostatic control. This study aimed to determine the efficacy of currently available hemostatic dressings as compared with the current Committee for Tactical Combat Casualty Care Guidelines standard of treatment for hemorrhage control (QuikClot Combat Gauze [QCG])...
August 2013: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/23707133/evaluation-of-hemostatic-field-dressing-for-bacteria-mycobacteria-or-fungus-contamination
#16
Clinton K Murray, Tyson Brunstetter, Miriam Beckius, James R Dunne, Katrin Mende
Infectious complications have a major impact on wounded warriors. Pathogens causing infections include multidrug-resistant bacteria, fungi, and mycobacteria. The potential sources for these pathogens include nosocomial transmission, the environment (e.g., dirt), or the patients (skin flora) themselves. The purpose of this pilot study was to explore the possibility that hemostatic field dressings might act as an inoculation source of pathogens into wounds. To accomplish this, hemostatic field dressings were assessed for the presence of bacterial, fungal, or mycobacterial contamination...
March 2013: Military Medicine
https://www.readbyqxmd.com/read/23702635/effects-of-ankaferd-blood-stopper-and-celox-on-the-tissue-factor-activities-of-warfarin-treated-rats
#17
COMPARATIVE STUDY
Sertac Aktop, Ebru Emekli-Alturfan, Cuneyt Ozer, Onur Gonul, Hasan Garip, Aysen Yarat, Kamil Goker
The aim of this study is to evaluate the effect of these new generation hemostatic agents on early-stage soft tissue healing of warfarin-treated rats by measuring the tissue factor (TF) activities. Rats in the warfarin group were treated intraperitonally with 0.1 mg/kg warfarin, and rats in the control group were treated with 1 mL/kg saline. All rats had 3 incisions on dorsal dermal tissue applied Celox, Ankaferd Blood Stopper (ABS), or no hemostatic agent. Six rats from each group were killed on day 4, and the other 6 were killed on day 8...
January 2014: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/23497917/chitosan-based-advanced-hemostatic-dressing-is-associated-with-decreased-blood-loss-in-a-swine-uncontrolled-hemorrhage-model
#18
Nicholas R Kunio, Gordon M Riha, Katherine M Watson, Jerome A Differding, Martin A Schreiber, Jennifer M Watters
BACKGROUND: The purpose of this study was to compare standard gauze (SG) and advanced hemostatic dressings in use by military personnel in a no-hold model. METHODS: A randomized, controlled trial was conducted using 36 swine. Animals underwent femoral arteriotomy, followed by 60 seconds of uncontrolled hemorrhage. After hemorrhage, packing with 1 of 3 dressings-SG, Combat Gauze (CG), or Celox Rapid gauze (XG)-and a 500-mL bolus of Hextend were initiated. Pressure was not held after packing, and animals were followed for 120 minutes...
May 2013: American Journal of Surgery
https://www.readbyqxmd.com/read/23427965/hemostasis-in-a-noncompressible-hemorrhage-model-an-end-user-evaluation-of-hemostatic-agents-in-a-proximal-arterial-injury
#19
RANDOMIZED CONTROLLED TRIAL
Steven Satterly, Daniel Nelson, Nathan Zwintscher, Morohunranti Oguntoye, Wayne Causey, Bryan Theis, Raywin Huang, Mohamad Haque, Matthew Martin, Gerald Bickett, Robert M Rush
OBJECTIVE: 1. Evaluate hemostatic bandages by the end user using subjective and objective criteria. 2. Determine if user training and education level impact overall hemostatic outcomes. 3. Our hypothesis was that prior medical training would be directly linked to improved hemostatic outcomes in noncompressible hemorrhage indepen- dent of dressing used. DESIGN: Military personnel were given standardized instruction on hemostatic dressings as part of a tactical combat casualty care course (TC3)...
March 2013: Journal of Surgical Education
https://www.readbyqxmd.com/read/23402073/the-use-of-celox-gauze-as-an-adjunct-to-pelvic-packing-in-otherwise-uncontrollable-pelvic-haemorrhage-secondary-to-penetrating-trauma
#20
G S Arul, D M Bowley, S DiRusso
Haemorrhage from severe pelvic fractures can be associated with significant mortality. Modern civilian trauma centres may manage these injuries with a combination of external pelvic fixation, extra-peritoneal packing and/or selective angiography; however, military patterns of wounding are different and deployed medical facilities may be resource constrained. We report two successful instances of pelvic packing using chitosan impregnated gauze (Celox) when conventional surgical attempts at vascular control had failed...
December 2012: Journal of the Royal Army Medical Corps
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