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Apparent diffusion coefficient

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https://www.readbyqxmd.com/read/29774894/value-of-diffusion-weighted-imaging-for-monitoring-tissue-change-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-therapy-in-bone-applications-an-ex-vivo-study
#1
Sharon L Giles, Jessica M Winfield, David J Collins, Ian Rivens, John Civale, Gail R Ter Haar, Nandita M deSouza
Background: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring soft tissue changes adjacent to bone during MR-guided HIFU. We evaluated the repeatability of the apparent diffusion coefficient (ADC) measurement, the temporal evolution of ADC change after sonication, and its relationship with thermal parameters. Methods: Ex-vivo experiments in lamb legs ( n = 8) were performed on a Sonalleve MR-guided HIFU system...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29774659/magnetic-resonance-imaging-evaluation-of-treatment-efficacy-and-prognosis-for-brain-metastases-in-lung-cancer-patients-after-radiotherapy-a-preliminary-study
#2
Yuhui Liu, Xibin Liu, Liang Xu, Liheng Liu, Yuhong Sun, Minghuan Li, Haiyan Zeng, Shuanghu Yuan, Jinming Yu
BACKGROUND: This study used magnetic resonance imaging (MRI) to monitor changes to brain metastases and investigate the imaging signs used to evaluate treatment efficacy and determine prognosis following radiotherapy for brain metastases from lung cancer. METHODS: A total of 60 non-small cell lung cancer patients with brain oligometastases were selected. MRI scans were conducted before and 3, 6, 9, 12, 18, 24, and 30 months after radiotherapy. The tumor and peritumoral edema diameters, Cho/Cr values, elevation of the Lip peak value, and whether the island (yu-yuan) sign or high-signal ring were present on T2 fluid-attenuated inversion recovery (FLAIR) imaging were recorded for each metastasis...
May 17, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29774316/dual-phase-adc-modelling-of-breast-masses-in-diffusion-weighted-imaging-comparison-with-histopathologic-findings
#3
Gökhan Ertaş, Can Onaygil, Onur Buğdaycı, Erkin Arıbal
Objective: To investigate the diagnostic value of dual-phase apparent diffusion coefficient (ADC) compared to traditional ADC values in quantitative diffusion-weighted imaging (DWI) for differentiating between benign and malignant breast masses. Materials and Methods: Diffusion-weighted images of pathologically confirmed 88 benign and 85 malignant lesions acquired using a 3.0T MR scanner were analyzed. Small region-of-interests focusing on the highest signal intensity of lesions were used...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774183/quantitative-parameters-of-intravoxel-incoherent-motion-diffusion-weighted-imaging-ivim-dwi-potential-application-in-predicting-pathological-grades-of-pancreatic-ductal-adenocarcinoma
#4
Wanling Ma, Guangwen Zhang, Jing Ren, Qi Pan, Didi Wen, Jinman Zhong, Zhuoli Zhang, Yi Huan
Background: The aim of this study was to compare intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) parameters such as standard apparent diffusion coefficient (ADCstandard ), pure diffusion coefficient (Dslow ), pseudodiffusion coefficient (Dfast ) and perfusion fraction (ƒ) for differentiating pancreatic ductal adenocarcinoma (PDAC) with different pathological grades. Methods: Institutional Review Board of our hospital approved this study protocol...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29774180/survival-prediction-based-on-qualitative-mri-diffusion-signature-in-patients-with-recurrent-high-grade-glioma-treated-with-bevacizumab
#5
Pradeep Goyal, Mary Tenenbaum, Sonali Gupta, Puneet S Kochar, Alok A Bhatt, Manisha Mangla, Yogesh Kumar, Rajiv Mangla
Background: Bevacizumab was approved by the FDA for the treatment of recurrent or progressive glioblastoma (GBM). Imaging responses are typically assessed by gadolinium-enhanced MRI. We sought to determine the significance of qualitative diffusion signature (manifest as variable degree of dark signal) on ADC maps in recurrent gliomas after treatment with bevacizumab. Methods: We performed an institutional review board (IRB) approved retrospective study on patients who underwent MRI of the brain after 8 weeks of receiving bevacizumab for recurrent glioma...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29772253/interstitial-ion-homeostasis-and-acid-base-balance-are-maintained-in-oedematous-brain-of-mice-with-acute-toxic-liver-failure
#6
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29771954/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-with-ivim-diffusion-weighted-mr-imaging-and-gd-eob-dtpa-enhanced-mr-imaging
#7
Wei Zhao, Wenguang Liu, Huaping Liu, Xiaoping Yi, Jiale Hou, Yigang Pei, Hui Liu, Deyun Feng, Liyu Liu, Wenzheng Li
Microvascular invasion (MVI) is regarded as one of the independent risk factors for recurrence and poor prognosis of hepatocellular carcinoma (HCC). The presence of MVI in HCCs was evaluated on the basis of pathological reports of surgical specimens and was defined as tumor within a vascular space lined by endothelium that was visible only on microscopy. The aim of the study was to investigate the usefulness of intravoxel incoherent motion (IVIM) diffusion weighted (DW) magnetic resonance (MR) imaging in predicting MVI of HCC...
2018: PloS One
https://www.readbyqxmd.com/read/29771445/tirofiban-combined-with-rt-pa-intraarterial-thrombolysis-improves-the-recanalization-rate-of-acute-middle-cerebral-artery-occlusion-in-rabbits
#8
Y-J Yu, W Xiong
OBJECTIVE: To investigate the curative effect of tirofiban combined with recombinant tissue-plasminogen activator (rt-PA) selective intra-arterial thrombolysis on acute middle cerebral artery occlusion (MCAO). MATERIALS AND METHODS: A total of 60 adult male Japanese white rabbits weighing 2.5-3.0 kg were selected, and the acute cerebral infarction model was established via autologous thromboembolism of middle cerebral artery. Rabbits were randomly divided into 4 groups: tirofiban group (Ti group, 5 μg/kg, n=15), rt-PA group (rt-PA group, 2 mg/kg, n=15), tirofiban + rt-PA group (Ti + rt-PA group, 3 μg/kg Ti + 1 mg/kg rt-PA, n=15), and control group (Co group, n=15)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770848/imaging-biomarkers-from-multiparametric-magnetic-resonance-imaging-are-associated-with-survival-outcomes-in-patients-with-brain-metastases-from-breast-cancer
#9
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
https://www.readbyqxmd.com/read/29770735/the-diagnostic-value-of-using-combined-mr-diffusion-parameters-to-differentiate-between-low-and-high-grade-meningioma
#10
Kerim Aslan, Hediye Pinar Gunbey, Leman Tomak, Lutfi Incesu
OBJECTIVE: The purpose of this study was to examine whether the combined use of MR diffusion parameters [Diffusion tensor imaging (DTI)-apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)] could provide a more accurate diagnosis in differentiating between low-grade and atypical/anaplastic (high-grade) meningioma. METHODS: Pathologically proven 45 meningioma patients [32 low-grade, 13 high-grade (11 atypical and 2 anaplastic)] who had received DTI before surgery were assessed retrospectively by 2 independent observers...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29763453/anisotropic-conductivity-tensor-imaging-for-transcranial-direct-current-stimulation-tdcs-using-magnetic-resonance-diffusion-tensor-imaging-mr-dti
#11
Mun Bae Lee, Hyung Joong Kim, Eung Je Woo, Oh In Kwon
Transcranial direct current stimulation (tDCS) is a widely used non-invasive brain stimulation technique by applying low-frequency weak direct current via electrodes attached on the head. The tDCS using a fixed current between 1 and 2 mA has relied on computational modelings to achieve optimal stimulation effects. Recently, by measuring the tDCS current induced magnetic field using an MRI scanner, the internal current pathway has been successfully recovered. However, up to now, there is no technique to visualize electrical properties including the electrical anisotropic conductivity, effective extracellular ion-concentration, and electric field using only the tDCS current in-vivo...
2018: PloS One
https://www.readbyqxmd.com/read/29761595/radiomics-analysis-of-apparent-diffusion-coefficient-in-cervical-cancer-a-preliminary-study-on-histological-grade-evaluation
#12
Ying Liu, Yuwei Zhang, Runfen Cheng, Shichang Liu, Fangyuan Qu, Xiaoyu Yin, Qin Wang, Bohan Xiao, Zhaoxiang Ye
BACKGROUND: The role of apparent diffusion coefficient (ADC)-based radiomics features in evaluating histopathological grade of cervical cancer is unresolved. PURPOSE: To determine if there is a difference between radiomics features derived from center-slice 2D versus whole-tumor volumetric 3D for ADC measurements in patients with cervical cancer regarding tumor histopathological grade, and systematically assess the impact of the b value on radiomics analysis in ADC quantifications...
May 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29761011/associations-between-apparent-diffusion-coefficient-and-electromyography-parameters-in-myositis-a-preliminary-study
#13
Hans-Jonas Meyer, Alexander Emmer, Malte Kornhuber, Alexey Surov
Objective: MRI is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Electromyography (EMG) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between ADC values and EMG findings in myositis patients. Method: Seven patients (eight investigated muscles) with myositis (mean age 51...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29755275/isolated-superior-oblique-muscle-extranodal-marginal-zone-b-cell-lymphoma-case-report
#14
Fatimah Alhammad, Azza Maktabi, Hind M Alkatan, Sahar M Elkhamary, Enmar Almazyad, Osama Al-Sheikh
We describe a rare case of isolated extraocular muscle ocular adnexal lymphoma of a middle-aged female who presented with redness in the left eye associated with progressive proptosis over one year. Magnetic resonance imaging of the orbit indicated isolated enlargement of the left superior oblique (SO) muscle with an apparent diffusion coefficient (ADC) of (0.77 ± 0.11 × 10-3  mm2 /s). Histopathology with immunohistochemical staining of the incisional biopsy from the SO muscle belly confirmed the diagnosis of extranodal marginal zone B cell lymphoma...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29753902/bilateral-upper-cerebellar-hemorrhage-due-to-pial-arteriovenous-fistula-and-its-pathophysiological-insight
#15
Yosuke Akamatsu, Toshiaki Hayashi, Kenichi Sato, Hiroshi Karibe, Motonobu Kameyama, Teiji Tominaga
OBJECTIVES: Bilateral upper cerebellar hemorrhage is extremely rare clinical entity, but relatively known as postoperative neurosurgical complication with as yet unknown etiology. Here, we report a case of bilateral upper cerebellar hemorrhage due to pial arteriovenous fistula and discussed possible pathophysiology of this bleeding pattern. CASE DESCRIPTION: A 4-year-old boy, who was previously healthy, presented with a sudden onset of headache, vomiting, and gait instability...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29753575/quantitative-apparent-diffusion-coefficient-mapping-may-predict-seizure-onset-in-children-with-sturge-weber-syndrome
#16
Anna L R Pinto, Yangming Ou, Mustafa Sahin, P Ellen Grant
BACKGROUND: Sturge-Weber syndrome (SWS) is often accompanied by seizures, stroke-like episodes, hemiparesis, and visual field deficits. This study aimed to identify early pathophysiologic changes that exist before the development of clinical symptoms and to evaluate if the apparent diffusion coefficient (ADC) map is a candidate early biomarker of seizure risk in patients with SWS. METHODS: This is a prospective cross-sectional study using quantitative ADC analysis to predict onset of epilepsy...
April 12, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29753491/comparison-of-the-diagnostic-value-of-monoexponential-biexponential-and-stretched-exponential-diffusion-weighted-mri-in-differentiating-tumor-stage-and-histological-grade-of-bladder-cancer
#17
Yanchun Wang, Daoyu Hu, Hao Yu, Yaqi Shen, Hao Tang, Ihab R Kamel, Zhen Li
RATIONALE AND OBJECTIVES: We aimed to determine the utility of various diffusion parameters obtained from monoexponential, biexponential, and stretched exponential diffusion-weighted imaging (DWI) models in differentiating tumor stage and grade of bladder cancer. MATERIALS AND METHODS: Forty-five patients with pathologically confirmed bladder cancer underwent multi-b-value DWI. An apparent diffusion coefficient (ADC) was calculated from DWI by using a monoexponential model...
May 9, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29752646/mri-features-after-prostatic-artery-embolization-for-the-treatment-of-medium-and-large-volume-benign-hyperplasia
#18
Hongtao Zhang, Yanguang Shen, Jingjing Pan, Haiyi Wang, Yan Zhong, Yingwei Wang, Huiyi Ye
PURPOSE: To assess magnetic resonance imaging (MRI) features after prostatic artery embolization (PAE) for the treatment of medium- and large-volume benign prostatic hyperplasia and to correlate prostate volume with clinical indexes. METHODS: We retrospectively evaluated 28 patients who underwent PAE. MRI examinations of the prostate were performed to evaluate signal intensity changes and the characteristics of infarcted areas. Prostate volume and the apparent diffusion coefficient (ADC) were measured at an average of 10 days post-PAE and at 1, 3, 6, and 12 months post-PAE...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29751058/imaging-brain-tumour-microstructure
#19
Markus Nilsson, Elisabet Englund, Filip Szczepankiewicz, Danielle van Westen, Pia C Sundgren
Imaging is an indispensable tool for brain tumour diagnosis, surgical planning, and follow-up. Definite diagnosis, however, often demands histopathological analysis of microscopic features of tissue samples, which have to be obtained by invasive means. A non-invasive alternative may be to probe corresponding microscopic tissue characteristics by MRI, or so called 'microstructure imaging'. The promise of microstructure imaging is one of 'virtual biopsy' with the goal to offset the need for invasive procedures in favour of imaging that can guide pre-surgical planning and can be repeated longitudinally to monitor and predict treatment response...
May 8, 2018: NeuroImage
https://www.readbyqxmd.com/read/29750794/apparent-diffusion-coefficient-of-hepatocellular-carcinoma-on-diffusion-weighted-imaging-histopathologic-tumor-grade-versus-arterial-vascularity-during-dynamic-magnetic-resonance-imaging
#20
In Kyung Park, Jeong-Sik Yu, Eun-Suk Cho, Joo Hee Kim, Jae-Joon Chung
OBJECTIVES: Apparent diffusion coefficient (ADC) has been suggested to reflect the tumor grades of hepatocellular carcinomas (HCCs); i.e., it can be used as a biomarker to predict the patients' prognosis. To verify its feasibility as a biomarker, the present study sought to determine how the ADC values of HCC are affected by a tumor's histopathologic grade and arterial vascularity. MATERIALS AND METHODS: From 131 consecutive patients, 141 surgically resected HCCs (16 well-differentiated [wd-HCCs], 83 moderately-differentiated [md-HCCs], and 42 poorly-differentiated HCCs [pd-HCCs]) were subjected to a comparison of the tumors' arterial vascularity (non-, slightly-, or markedly-hypervascular) determined on dynamic magnetic resonance imaging (MRI) and the ADC was measured retrospectively...
2018: PloS One
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