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https://www.readbyqxmd.com/read/28087112/the-impact-of-temperature-in-aortic-arch-surgery-patients-receiving-antegrade-cerebral-perfusion-for-30%C3%A2-minutes-how-relevant-is-it-really
#1
Ourania Preventza, Joseph S Coselli, Shahab Akvan, Sarang A Kashyap, Andrea Garcia, Katherine H Simpson, Matt D Price, Jessica Mayor, Kim I de la Cruz, Lorraine D Cornwell, Shuab Omer, Faisal G Bakaeen, Ricky J L Haywood-Watson, Athina Rammou
OBJECTIVE: We examined the early outcomes and the long-term survival associated with different degrees of hypothermia in patients who received antegrade cerebral perfusion (ACP) for >30 minutes. METHODS: During a 10-year period, 544 consecutive patients underwent proximal and total aortic arch surgery and received ACP for >30 minutes and 1 of 3 levels of hypothermia: deep (14.1°C-20°C; n = 116 [21.3%]), low-moderate (20.1°C-23.9°C; n = 262 [48.2%]), and high-moderate (24°C-28°C; n = 166 [30...
December 19, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28081137/anillin-phosphorylation-controls-timely-membrane-association-and-successful-cytokinesis
#2
Hyunjung Kim, James M Johnson, Robert F Lera, Sarang Brahma, Mark E Burkard
During cytokinesis, a contractile ring generates the constricting force to divide a cell into two daughters. This ring is composed of filamentous actin and the motor protein myosin, along with additional structural and regulatory proteins, including anillin. Anillin is a required scaffold protein that links the actomyosin ring to membrane and its organizer, RhoA. However, the molecular basis for timely action of anillin at cytokinesis remains obscure. Here, we find that phosphorylation regulates efficient recruitment of human anillin to the equatorial membrane...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28069993/development-and-validation-of-the-alzheimer-s-prevention-beliefs-measure-in-a-multi-ethnic-cohort-a-behavioral-theory-approach
#3
Alon Seifan, Christine A Ganzer, Francoise Vermeylen, Stephen Parry, Jifeng Zhu, Abigail Lyons, Richard Isaacson, Sarang Kim
BACKGROUND: Understanding health beliefs and how they influence willingness will enable the development of targeted curricula that maximize public engagement in Alzheimer's disease (AD) risk reduction behaviors. METHODS: Literature on behavioral theory and community input was used to develop and validate a health beliefs survey about AD risk reduction among 428 community-dwelling adults. Principal component analysis was performed to assess internal consistency. Linear regression was performed to identify key predictors of Willingness to engage in AD risk reduction behaviors...
January 9, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28060562/pathogen-recognition-and-toll-like-receptor-targeted-therapeutics-in-innate-immune-cells
#4
Sarang Tartey, Osamu Takeuchi
The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors to detect the invasion of pathogens and initiate protective responses. The intercellular and intracellular orchestration of signals from different PRRs, their endogenous or microbial ligands and accessory molecules determine the stimulatory or inhibitory responses. Progressing over the last two decades, considerable research on the molecular mechanisms underlying host-pathogen interactions has led to a paradigm shift of our understanding of TLR signaling in the innate immune system...
January 6, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28057695/cancer-and-cognitive-function-the-path-through-life-project
#5
Sarang Kim, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: A limited number of studies have shown that cancer diagnosis plays a protective role in Alzheimer's disease. However, the effect of the cancer diagnosis on general cognitive function/cognitive decline has not been previously examined. The aim of this study was to investigate the relationship between cancer diagnosis and cognitive function and mild cognitive impairment/disorders (MCI/MCD), adjusting for cancer treatments. METHODS: These data were drawn from the Personality and Total Health (PATH) Through Life Study, a population-based Australian cohort study...
January 4, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28056888/disposal-of-children-s-stools-and-its-association-with-childhood-diarrhea-in-india
#6
Rahul Bawankule, Abhishek Singh, Kaushalendra Kumar, Sarang Pedgaonkar
BACKGROUND: Children's stool disposal is often overlooked in sanitation programs of any country. Unsafe disposal of children's stool makes children susceptible to many diseases that transmit through faecal-oral route. Therefore, the study aims to examine the magnitude of unsafe disposal of children's stools in India, the factors associated with it and finally its association with childhood diarrhea. METHODS: Data from the third round of the National Family Health Survey (NFHS-3) conducted in 2005-06 is used to carry out the analysis...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28053379/closed-vs-open-nailing-for-displaced-middle-third-fracture-of-clavicle-does-it-matter
#7
Hrushikesh Saraf, Sarang Kasture
BACKGROUND: Intramedullary nailing for fractures of middle third clavicle has become increasingly popular. Though open nailing has been widely described, closed nailing finds less mention. OBJECTIVES: In this study we compared closed nailing with open nailing in fractures of middle third of clavicle to assess if the former holds any advantage. MATERIAL AND METHODS: 34 patients with closed nailing were compared to 31 patients with open nailing in terms of operative time, length of incision, pain, time to union and functional outcome...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28050526/non-surgical-management-of-teeth-with-wide-open-apices-and-large-periapical-lesions-a-conservative-reality
#8
Sarang Sharma, Shibani Grover, Pooja Dudeja, Vivek Sharma, Deepak Passi
No abstract text is available yet for this article.
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27987945/effect-of-calcium-sulphate-nanorods-on-mechanical-properties-of-chitosan-hydroxyethyl-methacrylate-hema-copolymer-nanocomposites
#9
Sarang S Bari, Satyendra Mishra
Copolymers of chitosan and hydroxyetheyl methacrylate (HEMA) were successfully synthesized using ceric ammonium nitrate (CAN) as an initiator, via in situ polymerization method, followed by efficacious preparation of their nanocomposites by incorporating calcium sulphate nanorods via solution blending process. Hydrophilicity studies confirmed that grafting of HEMA in the backbone of the hydrophobic chitosan chains induced the improvement in hydrophilicity of chitosan, while mechanical properties of the nanocomposites were also enhanced significantly up to 20%, due to availability of enlarged surface area and higher aspect ratio of CaSO4 nanorods...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987486/piperlongumine-derived-cyclic-sulfonamides-sultams-synthesis-and-in%C3%A2-vitro-exploration-for-therapeutic-potential-against-hela-cancer-cell-lines
#10
Nitin P Lad, Sarang Kulkarni, Rajiv Sharma, Malcolm Mascarenhas, Mahesh R Kulkarni, Shivaji S Pandit
A novel modification of piperlongumine is designed, bearing a cyclic sulphonamide (sultam) and its synthesis is described. For the first time herein we report the synthesis and biological evaluation of the natural product derived cyclic sulfonamides using Grubbs second generation catalyst (Grubbs II) via ring closing metathesis approach. Synthesis of a series of piperlongumine derived sultams is done in a moderate to good yield using Wittig reaction, Ring-Closing Metathesis (RCM) and, amide synthesis by using mixed anhydride, approach...
December 10, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27964981/aortic-root-surgery-with-circulatory-arrest-predictors-of-prolonged-postoperative-hospital-stay
#11
Ourania Preventza, Joseph S Coselli, Andrea Garcia, Shahab Akvan, Sarang Kashyap, Katherine H Simpson, Matt D Price, Kim I de la Cruz, Konstantinos Spiliotopoulos, Lorraine D Cornwell, Faisal G Bakaeen, Shuab Omer, Denton A Cooley
OBJECTIVE: Little is known about the outcomes of aortic root operations that involve inducing hypothermic circulatory arrest for relatively extensive proximal aortic surgery. We attempted to identify predictors of postoperative hospital length of stay (LOS) and factors that affect postoperative recovery. METHODS: During 2006-2014, 247 of 265 patients (93.2%) with disease extending into the aortic arch survived aortic root operations (206 elective, 41 urgent/emergent) in which hypothermic circulatory arrest with moderate hypothermia was used...
November 16, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27906349/single-longitudinal-mode-diamond-raman-laser-in-the-eye-safe-spectral-region-for-water-vapor-detection
#12
Oliver Lux, Soumya Sarang, Robert J Williams, Aaron McKay, Richard P Mildren
We report a narrowband and tunable diamond Raman laser generating eye-safe radiation suitable for water vapor detection. Frequency conversion of a tunable pump laser operating from 1063 to 1066 nm to the second order Stokes component in an external standing-wave cavity yielded 7 W of multimode output power in the wavelength range from 1483 to 1488 nm at a conversion efficiency of 21%. Stable single longitudinal mode operation was achieved over the whole tuning range at low power (0.1 W), whereas incorporation of a volume Bragg grating as an output coupler enabled much higher stable power to be attained (0...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906223/axial-super-resolution-evanescent-wave-tomography
#13
Sarang Pendharker, Swapnali Shende, Ward Newman, Stephen Ogg, Neda Nazemifard, Zubin Jacob
Optical tomographic reconstruction of a three-dimensional (3D) nanoscale specimen is hindered by the axial diffraction limit, which is 2-3 times worse than the focal plane resolution. We propose and experimentally demonstrate an axial super-resolution evanescent wave tomography method that enables the use of regular evanescent wave microscopes like the total internal reflection fluorescence microscope beyond surface imaging and achieve a tomographic reconstruction with axial super-resolution. Our proposed method based on Fourier reconstruction achieves axial super-resolution by extracting information from multiple sets of 3D fluorescence images when the sample is illuminated by an evanescent wave...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27891030/the-role-of-transforaminal-percutaneous-endoscopic-discectomy-in-lumbar-disc-herniations
#14
Sarang Gotecha, Deepak Ranade, Sujay Vikhe Patil, Ashish Chugh, Megha Kotecha, Shrikant Sharma, Prashant Punia
OBJECTIVES: To study 1)the efficacy of transforaminal percutaneous endoscopic lumbar discectomy in lumbar disc herniations.2) limitations and advantages of the surgical procedure. 3)morbidity and complications associated with the procedure. MATERIALS AND METHODS: This study was carried out on 120 patients who had single level herniated disc Pre-operative assessment of VAS and MSS scoring systems were documented one day prior to surgery. Post operative results were determined by MacNab criteria and by modified Suezawa and Schreiber clinical scoring system (MSS score)...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27833335/the-role-of-dentistry-in-disaster-management-and-victim-identification-an-overview-of-challenges-in-indo-nepal-scenario
#15
REVIEW
Shubha Ranjan Dutta, Purnima Singh, Deepak Passi, Don Varghese, Sarang Sharma
BACKGROUND: Recently, natural disasters and terrorist activities have been leading to mass casualty situations unexpectedly around the globe. In addition to the traditional emergency medical services centering around medically trained and paramedic personnel, dental practitioners having vital skills and attributes may be important in responding to a mass casualty situation. OBJECTIVE: This paper aims at discussing the role of dentists in disaster management and the role of forensic odontology in the disaster victim identification (DVI), its status in India and some suggestions to develop the plans for same...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27790601/erupted-large-anterior-maxillary-complex-odontoma-a-rare-dental-hamartoma
#16
Shubha Ranjan Dutta, Deepak Passi, Sarang Sharma, Purnima Singh, Musharib Ahmed
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27780578/moderate-hypothermia-at-warmer-temperatures-is-safe-in-elective-proximal-and-total-arch-surgery-results-in-665-patients
#17
Ourania Preventza, Joseph S Coselli, Andrea Garcia, Sarang Kashyap, Shahab Akvan, Katherine H Simpson, Matt D Price, Faisal G Bakaeen, Lorraine D Cornwell, Shuab Omer, Kim I de la Cruz, Scott A LeMaire, Denton A Cooley
OBJECTIVE: To evaluate adverse outcomes after elective aortic arch surgery performed at higher or lower temperatures (24.0°C-28.0°C vs 20.1°C-23.9°C) within the wide range of moderate hypothermia. METHODS: Over a 9-year period, a total of 665 patients underwent elective proximal (n = 479) or total (n = 186) arch replacement with moderate hypothermia and antegrade cerebral perfusion. Circulatory arrest was initiated at an actual temperature of 20.1°C to 23...
September 24, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27769226/the-effectiveness-of-a-housing-first-adaptation-for-ethnic-minority-groups-findings-of-a-pragmatic-randomized-controlled-trial
#18
Vicky Stergiopoulos, Agnes Gozdzik, Vachan Misir, Anna Skosireva, Aseefa Sarang, Jo Connelly, Adam Whisler, Kwame McKenzie
BACKGROUND: Little is known about the effectiveness of Housing First (HF) among ethnic minority groups, despite its growing popularity for homeless adults experiencing mental illness. This randomized controlled trial tests the effectiveness of a HF program using rent supplements and intensive case management, enhanced by anti-racism and anti-oppression practices for homeless adults with mental illness from diverse ethnic minority backgrounds. METHODS: This unblinded pragmatic field trial was carried out in community settings in Toronto, Canada...
October 21, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27768379/adiabatic-quantum-search-in-open-systems
#19
Dominik S Wild, Sarang Gopalakrishnan, Michael Knap, Norman Y Yao, Mikhail D Lukin
Adiabatic quantum algorithms represent a promising approach to universal quantum computation. In isolated systems, a key limitation to such algorithms is the presence of avoided level crossings, where gaps become extremely small. In open quantum systems, the fundamental robustness of adiabatic algorithms remains unresolved. Here, we study the dynamics near an avoided level crossing associated with the adiabatic quantum search algorithm, when the system is coupled to a generic environment. At zero temperature, we find that the algorithm remains scalable provided the noise spectral density of the environment decays sufficiently fast at low frequencies...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27761866/health-risk-assessment-of-heavy-metals-in-wheat-using-different-water-qualities-implication-for-human-health
#20
Zafar Iqbal Khan, Kafeel Ahmad, Sidrah Rehman, Samra Siddique, Humayun Bashir, Asma Zafar, Muhammad Sohail, Salem Alhajj Ali, Eugenio Cazzato, Giuseppe De Mastro
In the recent years, the use of sewage water for irrigation has attracted the attention of arid and semi-arid countries where the availability of fresh water is poor. Despite the potential use of sewage water in crop irrigation as effective and sustainable strategy, the environmental and human risks behind this use need to be deeply investigated. In this regard, an experiment was carried out under field conditions in Nursery, University College of Agriculture Sargodha, to evaluate the possible health risks of undesirable metals in wheat grains...
January 2017: Environmental Science and Pollution Research International
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