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Sarang Kim, Mitchell McMaster, Susan Torres, Kay L Cox, Nicola Lautenschlager, George W Rebok, Dimity Pond, Catherine D'Este, Ian McRae, Nicolas Cherbuin, Kaarin J Anstey
INTRODUCTION: It has been estimated that a 10%-25% reduction in seven key risk factors could potentially prevent 1.1-3.0 million Alzheimer's disease cases globally. In addition, as dementia is preceded by more subtle cognitive deficits which have substantial social and economic impact, effective preventative interventions would likely have more extensive benefits. The current study evaluates in primary care a multidomain risk-reduction intervention targeting adults with high risk of developing dementia...
March 17, 2018: BMJ Open
Ali Abbara, Shakunthala Narayanaswamy, Chioma Izzi-Engbeaya, Alexander N Comninos, Sophie Clarke, Zainab Malik, Deborah Papadopoulou, Ailish Clobentz, Zubair Sarang, Paul Bassett, Channa Jayasena, Waljit S Dhillo
<br>Background: Male testosterone levels decline by 1% per year from the age of 40yrs. Whilst a primary testicular deficit occurs, hypothalamic or pituitary dysregulation may also coexist. This study aimed to compare the hypothalamic response to kisspeptin and the pituitary response to GnRH of older men with those of young men. METHODS: Following 1 hour of baseline sampling, healthy older men (n=5, mean age 59.3±2.9yrs) received a 3 hour intravenous infusion (IVI) of either: vehicle, kisspeptin-54 0...
March 15, 2018: Neuroendocrinology
Hossein Zanjanian, Hamid Abdolabadi, Mohammad Hossein Niksokhan, Amin Sarang
Allocating water to organizational stakeholders poses a vital challenge to water managers. Organizations which benefit from water as the primary factor input attempt to achieve their objectives using cost-effective and quick-return strategies, such as increasing the water rights. In such circumstances, lack of water probably results in the conflict. Recognizing the management approaches, organizational priorities, and the stakeholders' influence power can play a dominant role in analyzing the future of such conflicts...
March 10, 2018: Journal of Environmental Management
Britta U Westner, Sarang S Dalal, Simon Hanslmayr, Tobias Staudigl
Single-trial analyses have the potential to uncover meaningful brain dynamics that are obscured when averaging across trials. However, low signal-to-noise ratio (SNR) can impede the use of single-trial analyses and decoding methods. In this study, we investigate the applicability of a single-trial approach to decode stimulus modality from magnetoencephalographic (MEG) high frequency activity. In order to classify the auditory versus visual presentation of words, we combine beamformer source reconstruction with the random forest classification method...
March 12, 2018: PLoS Computational Biology
George Cruzan, James S Bus, Melvin E Andersen, Gary P Carlson, Marcy I Banton, Satinder S Sarang, Robbie Waites
Based on 13 chronic studies, styrene exposure causes lung tumors in mice, but no tumor increases in other organs in mice or rats. Extensive research into the mode of action demonstrates the key events and human relevance. Key events are: metabolism of styrene by CYP2F2 in mouse lung club cells to ring-oxidized metabolites; changes in gene expression for metabolism of lipids and lipoproteins, cell cycle and mitotic M-M/G1 phases; cytotoxicity and mitogenesis in club cells; and progression to preneoplastic/neoplastic lesions in lung...
February 26, 2018: Regulatory Toxicology and Pharmacology: RTP
Shannon Robalino, Sarange B Nyakang'o, Fiona R Beyer, Chris Fox, Louise M Allan
BACKGROUND: The annual prevalence of falls in people with dementia ranges from 47 to 90%. Falls are a common reason for hospital admission in people with dementia, and there is limited research evidence regarding the care pathways experienced by this population. In addition to immediate management of an injury, prevention of further falls is likely to be an important part of any successful intervention. This review aims to assess the effectiveness of interventions for improving the physical and psychological wellbeing of people with dementia who have sustained a fall-related injury...
February 20, 2018: Systematic Reviews
Farzane Jamdar, Farah Farzaneh, Fariba Navidpour, Sarang Younesi, Payam Balvayeh, Maryamsadat Hosseini, Robabeh Ghodssi-Ghasemabadi
Background: Persistent infection with High Risk Human Papillomavirus (HR HPV) typesplaysamajor role in the development of cervical cancer. Therefore, the detection of HR HPV types is an essential part of cervical cancer screening. The aim of this study was to estimate the prevalence of HR HPV infection among healthy women undergoing routine cervical cancer screening in Iran. Methods: In this cross-sectional study,the results of HPV DNA typing in 2453 normal Iranian womenwhowere referred for routine cervical cancer screening from September 2015 to March 2017 were analyzed...
2018: Infectious Agents and Cancer
Zhenxu Bai, Robert J Williams, Hadiya Jasbeer, Soumya Sarang, Ondrej Kitzler, Aaron Mckay, Richard P Mildren
High average power lasers with high beam quality are critical for emerging applications in industry and research for defense, materials processing, and space applications. However, overcoming thermal effects in the gain medium remains the key challenge for increasing laser brightness at high powers. Here we report a means for increasing the beam brightness of high-power continuous-wave (CW) beams based on external cavity Raman lasers using diamond, a material with thermal properties far superior to any other laser material...
February 1, 2018: Optics Letters
Sarang Gopalakrishnan, K Ranjibul Islam, Michael Knap
We consider the dynamics of strongly localized systems subject to dephasing noise with arbitrary correlation time. Although noise inevitably induces delocalization, transport in the noise-induced delocalized phase is subdiffusive in a parametrically large intermediate-time window. We argue for this intermediate-time subdiffusive regime both analytically and using numerical simulations on single-particle localized systems. Furthermore, we show that normal diffusion is restored in the long-time limit, through processes analogous to variable-range hopping...
July 28, 2017: Physical Review Letters
Yogesh K Gurav, Pragya D Yadav, Mangesh D Gokhale, Tushar R Chiplunkar, Rajlakshmi Vishwanathan, Deepak Y Patil, Rajlaxmi Jain, Anita M Shete, Savita L Patil, G D Sarang, Gajanan N Sapkal, M D Andhare, Y R Sale, Pradeep S Awate, Devendra T Mourya
INTRODUCTION: Kyasanur forest disease (KFD) outbreak was confirmed in Dodamarg Taluka, Sindhudurga district (Maharashtra) in India during the year 2016. The rise in suspected KFD cases was reported in January 2016, peaked during March, and then declined gradually from April 2016. The outbreak was thoroughly investigated considering different socio-clinical parameters. METHODS: Total, 488 suspected KFD cases were investigated using KFD specific real-time RT-PCR and anti-KFDV IgM enzyme-linked immunosorbent assay (ELISA)...
January 16, 2018: Vector Borne and Zoonotic Diseases
Dipti Govil, Harihar Sahoo, Sarang P Pedgaonkar, Kailash Chandra Das, Hem Lhungdim
To assess the knowledge, attitude, and preventive practices related to kala-azar in Madhepura district of Bihar, a community-based cross-sectional study was carried out in November 2014. A total of 353 households were interviewed from 24 villages of four blocks of Madhepura district. Data were collected using structured interview schedule. For knowledge, attitude, and preventive practice indexes, scores were assigned to individual questions based on the accuracy of responses. Univariate and binary logistic regressions were applied for the analysis...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
Makiko T Quint, Som Sarang, David A Quint, Amir Keshavarz, Benjamin J Stokes, Anand Bala Subramaniam, Kerwyn Casey Huang, Ajay Gopinathan, Linda S Hirst, Sayantani Ghosh
We present three-dimensional microshells formed by self-assembly of densely-packed 5 nm gold nanoparticles (AuNPs). Surface functionalization of the AuNPs with custom-designed mesogenic molecules drives the formation of a stable and rigid shell wall, and these unique structures allow encapsulation of cargo that can be contained, virtually leakage-free, over several months. Further, by leveraging the plasmonic response of AuNPs, we can rupture the microshells using optical excitation with ultralow power (<2 mW), controllably and rapidly releasing the encapsulated contents in less than 5 s...
December 19, 2017: Scientific Reports
Sarang P Gumfekar, João B P Soares
This work investigates the effect of multifunctional poly (N-isopropyl acrylamide/acrylic acid/N-tert-butylacrylamide) [p(NIPAM-AA-NTBA)] ternary polymer on the sedimentation of kaolin clay - a major fraction of oil sands tailings. A series of linear, uncross-linked p(NIPAM), p(NIPAM/AA), and p(NIPAM/AA/NTBM) were synthesized as random copolymers, where all monomer units were randomly arranged along the polymer backbone and connected by covalent bonds. The ternary copolymer, used as a flocculant, exhibited thermo-sensitivity, anionic nature, and hydrophobic association due to NIPAM, AA, and NTBM, respectively...
March 2018: Chemosphere
Sarang S Koushik, David G Lott, Harish Ramakrishna
No abstract text is available yet for this article.
July 2017: Journal of Anaesthesiology, Clinical Pharmacology
Anjali Pandey, Sarang Bani, Prabhu Dutt, Naresh Kumar Satti, Krishan Avtar Suri, Ghulam Nabi Qazi
Alzheimer's disease (AD) is a chronic disorder that slowly worsens and impairs the person's memory, learning, reasoning, judgment, communication and familiar tasks with loss of orientation. AD is characterized clinically by cognitive deficit and pathologically by the deposition of β amyloid plaques, neurofibrillary tangles, associated with degeneration of the cholinergic forebrain. Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity...
November 3, 2017: Cytokine
Sarang Sharma, Vivek Sharma, Deepak Passi, Dhirendra Srivastava, Shibani Grover, Shubha Ranjan Dutta
Teeth having open apices in the absence of a natural apical constriction pose several challenges during conventional endodontic treatment, especially when establishing an apical seal. Treatment is further challenging when these teeth are associated with large periapical or cystic lesions having resulted in expansion and/or thinning of adjacent cortical plates. Although surgical intervention is commonly adopted in the management of such cases, a conservative treatment option offering equally good prognosis is always desirable...
October 24, 2017: Journal of Endodontics
Sarang Kasture, Koldo Azurza
INTRODUCTION: Triplane fracture is a rare adolescent ankle injury. Its association with ipsilateral tibial shaft fracture is very rarely reported in the literature. CASE REPORT: This is a case of a 14-year-old male who sustained a twisting injury to his right leg after a fall from a height. He sustained a minimally displaced spiral fracture of the mid-shaft of his right tibia with a concomitant ipsilateral two part triplane fracture of the ankle. He underwent minimally invasive percutaneous locking plate fixation for tibial fracture and percutaneous screw fixation for an ankle fracture...
May 2017: Journal of Orthopaedic Case Reports
Chan-Young Ock, Jun-Eul Hwang, Bhumsuk Keam, Sang-Bae Kim, Jae-Jun Shim, Hee-Jin Jang, Sarang Park, Bo Hwa Sohn, Minse Cha, Jaffer A Ajani, Scott Kopetz, Keun-Wook Lee, Tae Min Kim, Dae Seog Heo, Ju-Seog Lee
Immunotherapy has emerged as a promising anti-cancer treatment, however, little is known about the genetic characteristics that dictate response to immunotherapy. We develop a transcriptional predictor of immunotherapy response and assess its prediction in genomic data from ~10,000 human tissues across 30 different cancer types to estimate the potential response to immunotherapy. The integrative analysis reveals two distinct tumor types: the mutator type is positively associated with potential response to immunotherapy, whereas the chromosome-instable type is negatively associated with it...
October 19, 2017: Nature Communications
Sarang Kim, Laura R Willett, Wilbur J Pan, Joyce Afran, John A Walker, Judy A Shea
PURPOSE: To explore how students use and benefit from virtual patient cases (VPCs). METHOD: In academic years 2013-2014 and 2014-2015, cohorts of students in pediatrics (Peds), family medicine (FM), and internal medicine (IM) clerkships were allocated to either core required use (CRU) or self-directed use (SU) of MedU VPCs. Outcomes included number and time of case review, student perception of learning from VPCs, National Board of Medical Examiners (NBME) subject examination scores, and summative clinical ratings for medical knowledge and differential diagnoses/problem solving...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
Som Sarang, Sara Bonabi Naghadeh, Binbin Luo, Parveen Kumar, Edwin Betady, Vincent Tung, Michael Scheibner, Jin Z Zhang, Sayantani Ghosh
Surface functionalization of nanoscale materials has a significant impact on their properties. We have demonstrated the effect of different passivating ligands on the crystal phase of organometal halide perovskite quantum dots (PQDs). Using static and dynamic spectroscopy, we studied phase transitions in CH3NH3PbBr3 PQDs ligated with either octylaminebromide (P-OABr) or 3-aminopropyl triethoxysilane (P-APTES). Around 140 K, P-OABr underwent a structural phase transition from tetragonal to orthorhombic, established by the emergence of a higher energy band in the photoluminescence (PL) spectrum...
October 23, 2017: Journal of Physical Chemistry Letters
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