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https://www.readbyqxmd.com/read/28980966/civil-society-and-drugs-in-russia-moving-towards-the-conservative-agenda
#1
Anya Sarang
No abstract text is available yet for this article.
September 30, 2017: Lancet
https://www.readbyqxmd.com/read/28968494/sourcing-of-steam-and-electricity-for-carbon-capture-retrofits
#2
Sarang D Supekar, Steven J Skerlos
This paper compares different steam and electricity sources for carbon capture and sequestration (CCS) retrofits of pulverized coal (PC) and natural gas combined cycle (NGCC) power plants. Analytical expressions for the thermal efficiency of these power plants are derived under 16 different CCS retrofit scenarios for the purpose of illustrating their environmental and economic characteristics. The scenarios emerge from combinations of steam and electricity sources, fuel used in each source, steam generation equipment and process details, and the extent of CO2 capture...
October 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28962520/editor-s-highlight-complete-attenuation-of-mouse-lung-cell-proliferation-and-tumorigenicity-in-cyp2f2-knockout-and-cyp2f1-humanized-mice-exposed-to-inhaled-styrene-for-up-to-2%C3%A2-years-supports-a-lack-of-human-relevance
#3
George Cruzan, James S Bus, Marcy I Banton, Satinder S Sarang, Robbie Waites, Debra B Layko, James Raymond, Darol Dodd, Melvin E Andersen
Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic changes are dependent on CYP2F2 metabolism. The current study examined histopathology, cell proliferation, and genomic changes in CD-1, C57BL/6 (WT), CYP2F2(-/-) (KO), and CYP2F2(-/-) (CYP2F1, 2B6, 2A13-transgene) (TG; humanized) mice following exposure for up to 104 weeks to 0- or 120-ppm styrene vapor. Five mice per treatment group were sacrificed at 1, 26, 52, and 78 weeks...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28951217/assessing-molecular-initiating-events-mies-key-events-kes-and-modulating-factors-mfs-for-styrene-responses-in-mouse-lungs-using-whole-genome-gene-expression-profiling-following-1-day-and-multi-week-exposures
#4
Melvin E Andersen, George Cruzan, Michael B Black, Salil N Pendse, Darol Dodd, James S Bus, Satinder S Sarang, Marcy I Banton, Robbie Waites, Patrick D McMullen
Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three strains of male mice (the parental C57BL/6 strain, a CYP2F2(-/-) knock out and a CYP2F2(-/-) transgenic containing human CYP2F1, 2A13 and 2B6). Exposures were for 1-day and 1, 4 and 26weeks. After 1-day exposures at 1, 5, 10, 20, 40 and 120ppm significant increases in differentially expressed genes (DEGs) occurred only in parental strain lungs where there was already an increase in DEGs at 5ppm and then many thousands of DEGs by 120ppm...
September 23, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28945965/dewatering-oil-sands-tailings-with-degradable-polymer-flocculants
#5
Sarang P Gumfekar, Thomas R Rooney, Robin A Hutchinson, João B P Soares
We synthesized hydrolytically degradable cationic polymers by micellar radical polymerization of a short-chain polyester macromonomer, polycaprolactone choline iodide ester methacrylate (PCL2ChMA) with two polyester units, and used them to flocculate oil sands mature fine tailings (MFT). We evaluated the flocculation performance of the homopolymer and copolymers with 30 mol % acrylamide (AM) by measuring initial settling rate (ISR), supernatant turbidity, and capillary suction time (CST) of the sediments. Flocculants made with trimethylaminoethyl methacrylate chloride (TMAEMC), the monomer corresponding to PCLnChMA with n = 0, have improved performance over poly(PCL2ChMA) at equivalent loadings due to their higher charge density per gram of polymer...
October 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28910087/analysis-of-costs-and-time-frame-for-reducing-co2-emissions-by-70-in-the-u-s-auto-and-energy-sectors-by-2050
#6
Sarang D Supekar, Steven J Skerlos
Using a least-cost optimization framework, it is shown that unless emissions reductions beyond those already in place begin at the latest by 2025 (±2 years) for the U.S. automotive sector, and by 2026 (-3 years) for the U.S. electric sector, 2050 targets to achieve necessary within-sector preventative CO2 emissions reductions of 70% or more relative to 2010 will be infeasible. The analysis finds no evidence to justify delaying climate action in the name of reducing technological costs. Even without considering social and environmental damage costs, delaying aggressive climate action does not reduce CO2 abatement costs even under the most optimistic trajectories for improvements in fuel efficiencies, demand, and technology costs in the U...
September 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28892573/bicycling-suppresses-abnormal-beta-synchrony-in-the-parkinsonian-basal-ganglia
#7
Lena Storzer, Markus Butz, Jan Hirschmann, Omid Abbasi, Maciej Gratkowski, Dietmar Saupe, Jan Vesper, Sarang S Dalal, Alfons Schnitzler
OBJECTIVE: Freezing of gait is a poorly understood symptom of Parkinson disease, and can severely disrupt the locomotion of affected patients. However, bicycling ability remains surprisingly unaffected in most patients suffering from freezing, suggesting functional differences in the motor network. The purpose of this study was to characterize and contrast the oscillatory dynamics underlying bicycling and walking in the basal ganglia. METHODS: We present the first local field potential recordings directly comparing bicycling and walking in Parkinson disease patients with electrodes implanted in the subthalamic nuclei for deep brain stimulation...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28877984/%C3%AE-5%C3%AE-1-integrinpromotes-tension-dependent-mammary-epithelial-cell-invasion-by-engaging-the-fibronectin-synergy-site
#8
Y A Miroshnikova, G I Rozenberg, L Cassereau, M Pickup, J K Mouw, G Ou, K L Templeman, I Elloumi-Hannachi, K Gooch, A L Sarang-Sieminski, A J García, V M Weaver
Tumors are fibrotic and characterized by abundant, remodeled and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to promote focal adhesion formation and potentiate growth factor receptor signaling through ERK and PI3 kinase. Importantly, collagen cross-linking requires fibronectin. Fibrotic tumors contain abundant fibronectin and tumor cells frequently up regulate the fibronectin receptor α5β1 integrin...
September 6, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28869898/3-o-glucosylation-of-quercetin-enhances-inhibitory-effects-on-the-adipocyte-differentiation-and-lipogenesis
#9
Chang Won Lee, Jeong Yeon Seo, Jisun Lee, Ji Won Choi, Sarang Cho, Jae Youn Bae, Jae Kyung Sohng, Sung Oog Kim, Jihoon Kim, Yong Il Park
Glycosylation of natural flavonoids with various sugar moieties can affect their physicochemical and pharmacological properties. In this study, the plant flavonoids quercetin aglycon (Quer) and quercetin 3-O-glucoside (Q3G) were evaluated and compared for their potential anti-obesity effects. The Q3G dose-dependently reduced the TG contents and lipid accumulation in 3T3-L1 adipocyte cells, by 52% and 60% at 20μM, respectively, compared to differentiated control (100%), which were 1.6-fold and 2.4-fold higher reduction than Quer...
September 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28840829/transglutaminase-2-in-human-diseases
#10
Zsuzsa Szondy, Ilma Korponay-Szabó, Robert Király, Zsolt Sarang, Gregory J Tsay
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28781956/the-proteomic-profile-of-a-mouse-model-of-proliferative-vitreoretinopathy
#11
Bernadett Márkus, Zsuzsanna Pató, Zsolt Sarang, Réka Albert, József Tőzsér, Goran Petrovski, Éva Csősz
Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for PVR. A previously established mouse model, using dispase injection, was analyzed from the proteomic point of view, examining global protein profile changes by 2D electrophoresis, image analysis and HPLC-tandem mass spectrometry-based protein identification...
August 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28688663/comparing-traditional-and-novel-injury-scoring-systems-in-a-us-level-i-trauma-center-an-opportunity-for-improved-injury-surveillance-in%C3%A2-low-and-middle-income-countries
#12
COMPARATIVE STUDY
Adam D Laytin, Rochelle A Dicker, Martin Gerdin, Nobhojit Roy, Bhakti Sarang, Vineet Kumar, Catherine Juillard
BACKGROUND: In most low- and middle-income countries (LMICs), the resources to accurately quantify injury severity using traditional injury scoring systems are limited. Novel injury scoring systems appear to have adequate discrimination for mortality in LMIC contexts, but they have not been rigorously compared where traditional injury scores can be accurately calculated. To determine whether novel injury scoring systems perform as well as traditional ones in a HIC with complete and comprehensive data collection...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28682871/post-hoc-analyses-of-east-asian-patients-from-the-randomized-placebo-controlled-prevail-trial-of-enzalutamide-in-patients-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer
#13
RANDOMIZED CONTROLLED TRIAL
Choung Soo Kim, Young Deuk Choi, Sang Eun Lee, Hyun Moo Lee, Takeshi Ueda, Junji Yonese, Takashi Fukagai, Edmund Chiong, Weber Lau, Sarang Abhyankar, Ad Theeuwes, Bertrand Tombal, Tomasz M Beer, Go Kimura
BACKGROUND: Enzalutamide is an androgen receptor (AR) inhibitor that acts on different steps in the AR signaling pathway. In PREVAIL, an international, phase III, double-blind, placebo-controlled trial, enzalutamide significantly reduced the risk of radiographic progression by 81% (hazard ratio [HR], 0.19; P < .0001) and reduced the risk of death by 29% (HR, 0.71; P < .0001) compared with placebo in chemotherapy-naïve men with metastatic castration-resistant prostate cancer...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28632997/epidemiology-of-obesity-and-pharmacologic-treatment-options
#14
Vignesh Shettar, Sarang Patel, Srividya Kidambi
Prevalence of obesity and its related morbidity have increased to alarming levels in adults and children in the United States and globally. Weight loss results in improvement of much of the obesity-related morbidity. Lifestyle changes such as dietary modifications, increased physical activity, and behavioral therapy form the crux of weight management. However, many individuals need additional assistance (pharmacologic or surgical) to initiate or sustain weight loss. Pharmacologic therapy consists of a number of agents that work by decreasing appetite, gastric emptying, or nutrient absorption or by increasing satiety...
August 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28627457/analysis-of-the-origins-of-content-non-uniformity-in-high-shear-wet-granulation
#15
Sarang Oka, David Smrčka, Anjali Kataria, Heather Emady, Fernando Muzzio, František Štěpánek, Rohit Ramachandran
In this study, the origins of granule content non-uniformity in the high-shear wet granulation of a model two-component pharmaceutical blend were investigated. Using acetaminophen as the active pharmaceutical ingredient (API) and microcrystalline cellulose as the excipient, the distribution of the API across the granule size classes was measured for a range of conditions that differed in the duration of the initial dry mixing stage, the overall composition of the blend and the wet massing time. The coarse granule fractions were found to be systematically sub-potent, while the fines were enriched in the API...
August 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28621629/endoscopic-endonasal-odontoid-resection-with-real-time-intraoperative-image-guided-computed-tomography-report-of-4-cases
#16
Harminder Singh, Sarang Rote, Ajit Jada, Evan D Bander, Gustavo J Almodovar-Mercado, Walid I Essayed, Roger Härtl, Vijay K Anand, Theodore H Schwartz, Jeffrey P Greenfield
The authors present 4 cases in which they used intraoperative CT (iCT) scanning to provide real-time image guidance during endonasal odontoid resection. While intraoperative CT has previously been used as a confirmatory test after resection, to the authors' knowledge this is the first time it has been used to provide real-time image guidance during endonasal odontoid resection. The operating room setup, as well as the advantages and pitfalls of this approach, are discussed. A mobile intraoperative CT scanner was used in conjunction with real-time craniospinal neuronavigation in 4 patients who underwent endoscopic endonasal odontoidectomy for basilar invagination...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28559791/photogrammetry-based-head-digitization-for-rapid-and-accurate-localization-of-eeg-electrodes-and-meg-fiducial-markers-using-a-single-digital-slr-camera
#17
Tommy Clausner, Sarang S Dalal, Maité Crespo-García
The performance of EEG source reconstruction has benefited from the increasing use of advanced head modeling techniques that take advantage of MRI together with the precise positions of the recording electrodes. The prevailing technique for registering EEG electrode coordinates involves electromagnetic digitization. However, the procedure adds several minutes to experiment preparation and typical digitizers may not be accurate enough for optimal source reconstruction performance (Dalal et al., 2014). Here, we present a rapid, accurate, and cost-effective alternative method to register EEG electrode positions, using a single digital SLR camera, photogrammetry software, and computer vision techniques implemented in our open-source toolbox, janus3D...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28504165/calcium-silicate-nanowires-an-effective-alternative-for-improving-mechanical-properties-of-chitosan-hydroxyethyl-methacrylate-hema-copolymer-nanocomposites
#18
Sarang S Bari, Satyendra Mishra
Nanowires of calcium silicate were successfully synthesized by ultrasonic irradiation process and incorporated into chitosan and hydroxyetheyl methacrylate (HEMA) copolymer matrix by solution blending for efficacious preparation of biodegradable nanocomposites. Remarkable improvement in mechanical properties of the nanocomposites was noticed after micro-tensile analysis. Enlarged surface area and higher aspect ratio of CaSiO3 nanowires were the key factors responsible for such improvement. This was supported by EDS and XRD analysis in terms of proper distribution of nanofiller through the copolymer matrix and corresponding rise in percentage crystallanity respectively...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28403558/glutathione-biosynthesis-and-activity-of-dependent-enzymes-in-food-grade-lactic-acid-bacteria-harboring-multidomain-bifunctional-fusion-gene-gshf
#19
Sarang Dilip Pophaly, Poonam, Saurabh Dilip Pophaly, Suman Kapila, Dhiraj Kumar Nanda, Sudhir Kumar Tomar, Rameshwar Singh
AIMS: To assess glutathione (GSH) biosynthesis ability and activity of dependent enzymes in food grade lactic acid bacteria and correlating with genomic information on glutathione system in LAB. METHODS AND RESULTS: Whole genome sequences of twenty-six food grade LAB were screened for presence/absence of set of genes involved in de novo glutathione system. Multiple strains of S. thermophilus (37), Lb. casei (37), Lb. rhamnosus (4), Lb. paracasei (8) Lb. plantarum (23) & Lb...
April 12, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28316924/newer-proposed-classification-of-periimplant-defects-a-critical-update
#20
REVIEW
Deepak Passi, Mahinder Singh, Shubha Ranjan Dutta, Sarang Sharma, Mansi Atri, Jyoti Ahlawat, Abhinav Jain
The term peri-implantitis is used to describe a destructive inflammatory process affecting the soft and hard tissues around osseo integrated implants, leads to the formation of a peri-implant pocket and loss of supporting bone. Predisposing factors are Poor Plaque Control, inflammation, infection, Smoking, Diabetes and Occlusal Overload. It is diagnosed on the basis of clinical and radiographic interpretation and still no definite criteria have been proposed for the diagnosis and treatment of peri-implantitis...
January 2017: Journal of Oral Biology and Craniofacial Research
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