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https://www.readbyqxmd.com/read/28403558/glutathione-biosynthesis-and-activity-of-dependent-enzymes-in-food-grade-lactic-acid-bacteria-harboring-multidomain-bifunctional-fusion-gene-gshf
#1
Sarang Dilip Pophaly, Poonam, Saurabh Dilip Pophaly, Suman Kapila, Dhiraj Kumar Nanda, Sudhir Kumar Tomar, Rameshwar Singh
AIMS: To assess glutathione (GSH) biosynthesis ability and activity of dependent enzymes in food grade lactic acid bacteria and correlating with genomic information on glutathione system in LAB. METHODS AND RESULTS: Whole genome sequences of twenty-six food grade LAB were screened for presence/absence of set of genes involved in de novo glutathione system. Multiple strains of S. thermophilus (37), Lb. casei (37), Lb. rhamnosus (4), Lb. paracasei (8) Lb. plantarum (23) & Lb...
April 12, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28316924/newer-proposed-classification-of-periimplant-defects-a-critical-update
#2
REVIEW
Deepak Passi, Mahinder Singh, Shubha Ranjan Dutta, Sarang Sharma, Mansi Atri, Jyoti Ahlawat, Abhinav Jain
The term peri-implantitis is used to describe a destructive inflammatory process affecting the soft and hard tissues around osseo integrated implants, leads to the formation of a peri-implant pocket and loss of supporting bone. Predisposing factors are Poor Plaque Control, inflammation, infection, Smoking, Diabetes and Occlusal Overload. It is diagnosed on the basis of clinical and radiographic interpretation and still no definite criteria have been proposed for the diagnosis and treatment of peri-implantitis...
January 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28315019/an-endophytic-fungus-gibberella-moniliformis-from-lawsonia-inermis-l-produces-lawsone-an-orange-red-pigment
#3
Hatnagar Sarang, Pijakala Rajani, Madhugiri Mallaiah Vasanthakumari, Patel Mohana Kumara, Ramamoorthy Siva, Gudasalamani Ravikanth, R Uma Shaanker
Lawsone (2-hydroxy-1, 4-napthoquinone), also known as hennotannic acid, is an orange red dye used as a popular skin and hair colorant. The dye is produced in the leaves of Lawsonia inermis L, often referred to as the "henna" tree. In this study, we report the production of lawsone by an endophytic fungus, Gibberella moniliformis isolated from the leaf tissues of Lawsonia inermis. The fungus produced the orange-red dye in potato dextrose agar and broth, independent of the host tissue. Presence of lawsone was confirmed spectrometrically using HPLC and ESI-MS/MS analysis...
March 17, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28274522/preoperative-glycosylated-hemoglobin-a-risk-factor-for-patients-undergoing-coronary-artery-bypass
#4
Pradeep Narayan, Sarang Naresh Kshirsagar, Chandan Kumar Mandal, Paramita Auddya Ghorai, Yashaskar Manjunatha Rao, Debasis Das, Atanu Saha, Saibal Roy Chowdhury, Emmanuel Rupert, Mrinalendu Das
BACKGROUND: The prevalence of diabetes in the population of patients presenting with coronary artery disease continues to rise. The aim of this study was to assess whether high Glycosylated hemoglobin (HbA1c) was associated with adverse outcomes in patients undergoing elective coronary artery bypass grafting. METHODS: A retrospective observational study on prospectively collected data in 4,678 patients undergoing elective, isolated coronary artery bypass graft procedures in a single institution over a 4-year period was conducted...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28257483/evaluation-of-90-day-repeated-dose-oral-toxicity-and-reproductive-developmental-toxicity-of-3-hydroxypterostilbene-in-experimental-animals
#5
Muhammed Majeed, Sarang Bani, Sankaran Natarajan, Anjali Pandey, Naveed S
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium. Despite many proposed therapeutic applications, the safety profile of 3'-HPT has not been established. The present work investigated 90 day repeated oral dose and reproductive (developmental) toxicity of 3'-HPT as a test substance in rats as per OECD guidelines. 90 day toxicity was conducted in sixty Sprague Dawley rats of each sex (120 rats), grouped into six dosage groups of 0 (control), 0 (control recovery), 20 (low dose), 80 (mid dose), 200 (high dose) and 200 (high dose recovery) mg/kg bwt/day (body weight/day) respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28255242/braf-v600-mutations-in-solid-tumors-other-than-metastatic-melanoma-and-papillary-thyroid-cancer-or-multiple-myeloma-a-screening-study
#6
Allen L Cohn, Bann-Mo Day, Sarang Abhyankar, Edward McKenna, Todd Riehl, Igor Puzanov
BACKGROUND: Mutations in the BRAF gene have been implicated in several human cancers. The objective of this screening study was to identify patients with solid tumors (other than metastatic melanoma or papillary thyroid cancer) or multiple myeloma harboring activating BRAF(V600) mutations for enrollment in a vemurafenib clinical study. METHODS: Formalin-fixed, paraffin-embedded tumor samples were collected and sent to a central laboratory to identify activating BRAF(V600) mutations by bidirectional direct Sanger sequencing...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28250906/zika-virus-diseases-the-new-face-of-an-ancient-enemy-as-global-public-health-emergency-2016-brief-review-and-recent-updates
#7
REVIEW
Deepak Passi, Sarang Sharma, Shubha Ranjan Dutta, Musharib Ahmed
Zika virus (ZIKV) disease is caused by a virus transmitted by Aedes mosquito. It presents as flu-like symptoms lasting for 5-7 days and shows potential association with neurological and autoimmune complications such as congenital microcephaly and adult paralysis disorder, Guillain-Barré syndrome. Treatment measures are conservative as the disease is self-limiting. ZIKV earlier affected several tropical regions of Africa and Asia from 1951 to 2006. Subsequently, it moved out from these regions to land as outbreaks in Yap Island, French Polynesia, South America, and most recently in Brazil...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28240027/transport-limited-adsorption-of-plasma-proteins-on-bimodal-amphiphilic-polymer-co-networks-real-time-studies-by-spectroscopic-ellipsometry
#8
Gustavo Guzman, Sarang M Bhaway, Turgut Nugay, Bryan D Vogt, Mukerrem Cakmak
Traditional hydrogels are commonly limited by poor mechanical properties and low oxygen permeability. Bimodal amphiphilic co-networks (β-APCNs) are a new class of materials that can overcome these limitations by combining hydrophilic and hydrophobic polymer chains within a network of co-continuous morphology. Applications that can benefit from these improved properties include therapeutic contact lenses, enzymatic catalysis supports, and immunoisolation membranes. The continuous hydrophobic phase could potentially increase the adsorption of plasma proteins in blood-contacting medical applications and compromise in vivo material performance, so it is critical to understand the surface characteristics of β-APCNs and adsorption of plasma proteins on β-APCNs...
March 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28223454/dynamic-expansion-and-contraction-of-caga-copy-number-in-helicobacter-pylori-impact-development-of-gastric-disease
#9
Sungil Jang, Hanfu Su, Faith C Blum, Sarang Bae, Yun Hui Choi, Aeryun Kim, Youngmin A Hong, Jinmoon Kim, Ji-Hye Kim, Niluka Gunawardhana, Yeong-Eui Jeon, Yun-Jung Yoo, D Scott Merrell, Linhu Ge, Jeong-Heon Cha
Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including gastric cancer. Patients infected with H. pylori strains that express CagA are at even greater risk of gastric carcinoma. Given the importance of CagA, this report describes a new molecular mechanism by which the cagA copy number dynamically expands and contracts in H. pylori Analysis of strain PMSS1 revealed a heterogeneous population in terms of numbers of cagA copies; strains carried from zero to four copies of cagA that were arranged as direct repeats within the chromosome...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28145689/operando-grazing-incidence-small-angle-x-ray-scattering-x-ray-diffraction-of-model-ordered-mesoporous-lithium-ion-battery-anodes
#10
Sarang M Bhaway, Zhe Qiang, Yanfeng Xia, Xuhui Xia, Byeongdu Lee, Kevin G Yager, Lihua Zhang, Kim Kisslinger, Yu-Ming Chen, Kewei Liu, Yu Zhu, Bryan D Vogt
Emergent lithium-ion (Li(+)) batteries commonly rely on nanostructuring of the active electrode materials to decrease the Li(+) ion diffusion path length and to accommodate the strains associated with the insertion and de-insertion of Li(+), but in many cases these nanostructures evolve during electrochemical charging-discharging. This change in the nanostructure can adversely impact performance, and challenges remain regarding how to control these changes from the perspective of morphological design. In order to address these questions, operando grazing-incidence small-angle X-ray scattering and X-ray diffraction (GISAXS/GIXD) were used to assess the structural evolution of a family of model ordered mesoporous NiCo2O4 anode films during battery operation...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28111623/bilateral-simultaneous-traumatic-thumb-injuries-extensor-pollicis-longus-rupture-on-one-side-and-ulnar-collateral-ligament-on-the-other-case-report
#11
Sarang Kasture, Raj Sakamuri
INTRODUCTION: Though isolated traumatic extensor pollicislongus rupture and ulnar collateral ligament rupture of the metacarpophalangeal joint of the thumb are well known injuries, it is rare to have simultaneous bilateral thumb injuries from a single traumatic event. In this article, we report simultaneous bilateral traumatic thumb injury with extensor pollicislongus tendon rupture on one side and ulnar collateral ligament tear on the other side. To the best of our knowledge, such injury has never been reported in the English literature...
April 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28087112/the-impact-of-temperature-in-aortic-arch-surgery-patients-receiving-antegrade-cerebral-perfusion-for-30%C3%A2-minutes-how-relevant-is-it-really
#12
Ourania Preventza, Joseph S Coselli, Shahab Akvan, Sarang A Kashyap, Andrea Garcia, Katherine H Simpson, Matt D Price, Jessica Mayor, Kim I de la Cruz, Lorraine D Cornwell, Shuab Omer, Faisal G Bakaeen, Ricky J L Haywood-Watson, Athina Rammou
OBJECTIVE: We examined the early outcomes and the long-term survival associated with different degrees of hypothermia in patients who received antegrade cerebral perfusion (ACP) for >30 minutes. METHODS: During a 10-year period, 544 consecutive patients underwent proximal and total aortic arch surgery and received ACP for >30 minutes and 1 of 3 levels of hypothermia: deep (14.1°C-20°C; n = 116 [21.3%]), low-moderate (20.1°C-23.9°C; n = 262 [48.2%]), and high-moderate (24°C-28°C; n = 166 [30...
December 19, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28081137/anillin-phosphorylation-controls-timely-membrane-association-and-successful-cytokinesis
#13
Hyunjung Kim, James M Johnson, Robert F Lera, Sarang Brahma, Mark E Burkard
During cytokinesis, a contractile ring generates the constricting force to divide a cell into two daughters. This ring is composed of filamentous actin and the motor protein myosin, along with additional structural and regulatory proteins, including anillin. Anillin is a required scaffold protein that links the actomyosin ring to membrane and its organizer, RhoA. However, the molecular basis for timely action of anillin at cytokinesis remains obscure. Here, we find that phosphorylation regulates efficient recruitment of human anillin to the equatorial membrane...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28069993/development-and-validation-of-the-alzheimer-s-prevention-beliefs-measure-in-a-multi-ethnic-cohort-a-behavioral-theory-approach
#14
Alon Seifan, Christine A Ganzer, Francoise Vermeylen, Stephen Parry, Jifeng Zhu, Abigail Lyons, Richard Isaacson, Sarang Kim
BACKGROUND: Understanding health beliefs and how they influence willingness will enable the development of targeted curricula that maximize public engagement in Alzheimer's disease (AD) risk reduction behaviors. METHODS: Literature on behavioral theory and community input was used to develop and validate a health beliefs survey about AD risk reduction among 428 community-dwelling adults. Principal component analysis was performed to assess internal consistency. Linear regression was performed to identify key predictors of Willingness to engage in AD risk reduction behaviors...
January 9, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28060562/pathogen-recognition-and-toll-like-receptor-targeted-therapeutics-in-innate-immune-cells
#15
Sarang Tartey, Osamu Takeuchi
The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors to detect the invasion of pathogens and initiate protective responses. The intercellular and intracellular orchestration of signals from different PRRs, their endogenous or microbial ligands and accessory molecules determine the stimulatory or inhibitory responses. Progressing over the last two decades, considerable research on the molecular mechanisms underlying host-pathogen interactions has led to a paradigm shift of our understanding of TLR signaling in the innate immune system...
January 6, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28057695/cancer-and-cognitive-function-the-path-through-life-project
#16
Sarang Kim, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: A limited number of studies have shown that cancer diagnosis plays a protective role in Alzheimer's disease. However, the effect of the cancer diagnosis on general cognitive function/cognitive decline has not been previously examined. The aim of this study was to investigate the relationship between cancer diagnosis and cognitive function and mild cognitive impairment/disorders (MCI/MCD), adjusting for cancer treatments. METHODS: These data were drawn from the Personality and Total Health (PATH) Through Life Study, a population-based Australian cohort study...
January 4, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28056888/disposal-of-children-s-stools-and-its-association-with-childhood-diarrhea-in-india
#17
Rahul Bawankule, Abhishek Singh, Kaushalendra Kumar, Sarang Pedgaonkar
BACKGROUND: Children's stool disposal is often overlooked in sanitation programs of any country. Unsafe disposal of children's stool makes children susceptible to many diseases that transmit through faecal-oral route. Therefore, the study aims to examine the magnitude of unsafe disposal of children's stools in India, the factors associated with it and finally its association with childhood diarrhea. METHODS: Data from the third round of the National Family Health Survey (NFHS-3) conducted in 2005-06 is used to carry out the analysis...
January 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28053379/closed-vs-open-nailing-for-displaced-middle-third-fracture-of-clavicle-does-it-matter
#18
Hrushikesh Saraf, Sarang Kasture
BACKGROUND: Intramedullary nailing for fractures of middle third clavicle has become increasingly popular. Though open nailing has been widely described, closed nailing finds less mention. OBJECTIVES: In this study we compared closed nailing with open nailing in fractures of middle third of clavicle to assess if the former holds any advantage. MATERIAL AND METHODS: 34 patients with closed nailing were compared to 31 patients with open nailing in terms of operative time, length of incision, pain, time to union and functional outcome...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28050526/non-surgical-management-of-teeth-with-wide-open-apices-and-large-periapical-lesions-a-conservative-reality
#19
Sarang Sharma, Shibani Grover, Pooja Dudeja, Vivek Sharma, Deepak Passi
No abstract text is available yet for this article.
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27987945/effect-of-calcium-sulphate-nanorods-on-mechanical-properties-of-chitosan-hydroxyethyl-methacrylate-hema-copolymer-nanocomposites
#20
Sarang S Bari, Satyendra Mishra
Copolymers of chitosan and hydroxyetheyl methacrylate (HEMA) were successfully synthesized using ceric ammonium nitrate (CAN) as an initiator, via in situ polymerization method, followed by efficacious preparation of their nanocomposites by incorporating calcium sulphate nanorods via solution blending process. Hydrophilicity studies confirmed that grafting of HEMA in the backbone of the hydrophobic chitosan chains induced the improvement in hydrophilicity of chitosan, while mechanical properties of the nanocomposites were also enhanced significantly up to 20%, due to availability of enlarged surface area and higher aspect ratio of CaSO4 nanorods...
February 10, 2017: Carbohydrate Polymers
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