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https://www.readbyqxmd.com/read/29744908/dose-response-relationships-between-internally-deposited-uranium-and-select-health-outcomes-in-gaseous-diffusion-plant-workers-1948-2011
#1
James H Yiin, Jeri L Anderson, Stephen J Bertke, David J Tollerud
OBJECTIVE: To examine dose-response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers. METHODS: Cox regression was conducted to examine associations between selected health outcomes and cumulative internal uranium with consideration for external ionizing radiation, work-related medical X-rays and contaminant radionuclides technetium (99 Tc) and plutonium (239 Pu) as potential confounders. RESULTS: Elevated and monotonically increasing mortality risks were observed for kidney cancer, chronic renal diseases, and multiple myeloma, and the association with internal uranium absorbed organ dose was statistically significant for multiple myeloma...
May 9, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29658289/cancer-risk-following-alpha-emitter-exposure
#2
M Tirmarche
The International Commission on Radiological Protection (ICRP) mandated a task group (Task Group 64) to review recently published epidemiological studies related to cancer risk and incorporated alpha emitters, and to evaluate whether the results might consolidate or challenge assumptions underlying the current radiation protection system. Three major alpha emitters were considered: radon and its decay products, plutonium, and uranium. Results came mainly from cohorts of workers, while for radon, major studies of the general population contributed to a better understanding of the risk of lung cancer at low and chronic exposure...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29595754/the-importance-and-quantification-of-plutonium-binding-in-human-lungs
#3
Alan Birchall, Matthew Puncher, Alan Hodgson, Sergei Y Tolmachev
Epidemiological studies have shown that the main risk arising from exposure to plutonium aerosols is lung cancer, with other detrimental effects in the bone and liver. A realistic assessment of these risks, in turn, depends on the accuracy of the dosimetric models used to calculate doses in such studies. A state-of-the-art biokinetic model for plutonium, based on the current International Commission on Radiological Protection biokinetic model, has been developed for this purpose in an epidemiological study involving the plutonium exposure of Mayak workers in Ozersk, Russia...
March 28, 2018: Health Physics
https://www.readbyqxmd.com/read/29425784/the-reach-of-human-health-risks-associated-with-metals-metalloids-in-water-and-vegetables-along-a-contaminated-river-catchment-south-africa-and-mozambique
#4
Bettina Genthe, Thandi Kapwata, Wouter Le Roux, Jessica Chamier, Caradee Y Wright
BACKGROUND: Anthropogenic pollution was identified as an environmental problem of concern when, in 2008, dozens of crocodiles died in the Olifants River catchment near the border of South Africa and Mozambique. Given the close proximity of households to the river and their making use of river water, we aimed to determine to what extent water pollution has an impact on health of indigent communities in South Africa and Mozambique in the catchment area. METHODS: Water and vegetable samples were collected from the study areas...
May 2018: Chemosphere
https://www.readbyqxmd.com/read/29286493/twenty-five-years-of-the-national-academy-of-medical-sciences-of-ukraine-progress-and-priorities-for-future-of-radiation-medicine-and-biology
#5
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29215327/factors-modifying-the-radon-related-lung-cancer-risk-at-low-exposures-and-exposure-rates-among-german-uranium-miners
#6
M Kreuzer, C Sobotzki, M Schnelzer, N Fenske
It is still not fully understood whether and how factors such as time, age and smoking modify the relationship between lung cancer and radon at low exposures and exposure rates. Improved knowledge is necessary for the dose conversion of radon in working level month (WLM) into effective dose, as currently discussed by the International Commission on Radiological Protection (ICRP). An update of the German uranium miner cohort study (n = 58,974 men) with a 10-year extension of mortality follow-up (1946-2013) was used to further examine this issue...
February 2018: Radiation Research
https://www.readbyqxmd.com/read/29123148/radiological-investigation-of-high-background-radiation-areas
#7
Fawzia Mubarak, M Fayez-Hassan, N A Mansour, Talaat Salah Ahmed, Abdallah Ali
In this paper, we used the Hyper-Pure Germanium (HPGe) detector to measure 30 samples which are collected from north of Nile Delta near Rosetta beach in Egypt. The activity of primordial radionuclides, such as238 U,235 U,232 Th, and40 K was estimated. Concentrations ranged between 36.5-177.4, 50-397.5 and 56.1-168.9 Bq.kg-1 for238 U,232 Th and40 K respectively. Activity concentration of235 U and the variation in uranium isotopic ratio235 U/238 U was calculated. External hazard indices (Hex ) (or radium equivalent activity Raeq ), activity concentration indices (I), alpha index (Iα ), absorbed outdoor gamma dose rate (Dout ), effective outdoor gamma dose rate (Eout ) and Excess Lifetime Cancer Risk (ELCR) due to different samples are estimated...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28981856/comparative-study-of-radon-exposure-in-canadian-homes-and-uranium-mines-a-discussion-on-the-importance-of-national-radon-program
#8
Jing Chen
The history of lung cancer in uranium miners is well known for over hundreds of years when the disease was referred to as 'miner's disease' or 'mountain sickness'. Radon levels in uranium mines have decreased significantly over the past 30 years as a result of effective radiation protection measures at workplaces. For the most recent 10-year period, the average radon concentrations to underground and surface workers in Canadian uranium mines were 111 and 11 Bq m-3, respectively. Based on the recent radon survey carried out in roughly 14 000 homes in 121 health regions across Canada and the more recent radon and thoron survey in 33 Canadian cities and 4000 homes, the average radon concentration in Canadian homes is 77 Bq m-3...
November 1, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28952299/no-evaluation-of-serum-p53-levels-in-iraqi-female-breast-cancer-patients
#9
Ferdous A Jabir, Wisam H Hoidy
Breast cancer is the most common cancer diagnosed and the second leading cause of cancer death among Iraqi women. The population was exposed to high levels of depleted uranium following the first and second Gulf Wars and this might be a risk factor. Protein 53 (p53) or Tumor protein 53 (Tp53) was originally defined as an oncogenic protein. The aim of the study was to evaluate P-53 serum concentrations in fifty Iraqi female breast cancer patients and twenty five healthy volunteers using the ELISA technique. All these patients attended the Teaching Hospital of AL Diwaniyah during the period between June 2016 to March 2017...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28940040/analysis-of-mortality-in-a-pooled-cohort-of-canadian-and-german-uranium-processing-workers-with-no-mining-experience
#10
Lydia B Zablotska, Nora Fenske, Maria Schnelzer, Sergey Zhivin, Dominique Laurier, Michaela Kreuzer
PURPOSE: Long-term health risks of occupational exposures to uranium processing were examined to better understand potential differences with uranium underground miners and nuclear reactor workers. METHODS: A cohort study of mortality of workers from Port Hope, Canada (1950-1999) and Wismut, Germany (1946-2008) employed in uranium milling, refining, and processing was conducted. Poisson regression was used to evaluate the association between cumulative exposures to radon decay products (RDP) and gamma-rays and causes of death potentially related to uranium processing...
January 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28925920/low-radon-exposure-and-mortality-among-jouac-uranium-miners-an-update-of-the-french-cohort-1946-2007
#11
Estelle Rage, Sylvaine Caër-Lorho, Dominique Laurier
After the extension of the French cohort of uranium miners with the inclusion of workers employed in the Jouac mines, this article seeks to describe the new Jouac cohort and to estimate mortality risks, as well as to quantify their relation to radon exposure in this extended cohort. The Jouac cohort includes 458 miners hired by the Société des Mines de Jouac between 1957 and 2001. As there is no measurement of radon exposure before 1978 were unavailable, only the post-1977 Jouac cohort (n=314) has been included in the French cohort, creating an extended cohort of 5400 French uranium miners followed up from 1946 to 2007...
September 19, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28923384/synthesis-and-structure-elucidation-of-novel-salophen-based-dioxo-uranium-vi-complexes-in-vitro-and-in-silico-studies-of-their-dna-bsa-binding-properties-and-anticancer-activity
#12
S Yousef Ebrahimipour, Maryam Mohamadi, Masoud Torkzadeh Mahani, Jim Simpson, Joel T Mague, Iran Sheikhshoaei
The synthesis and characterization of three dioxo U(VI) complexes, [UO2(L(1))(OH2)], [UO2(L(2))DMF], and [UO2(L(2))DMSO], [L(1)](2-) = 1,1'-(4-methyl-1,2-phenylenebis (nitrilomethylidyne))di-2-naphtholate: [L(2)](2-) = 1,1'-(o-phenylenebis (nitrilomethylidyne)) di-2-naphtholate, are reported. Elemental analysis, FT-IR, (1)HNMR, UV-Vis spectroscopy, molar conductivity and single crystal X-ray diffraction were used to characterize the complexes. It was found that the complexes adopt a distorted pentagonal bipyramidal coordination geometry...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28815680/study-of-coverage-of-confidence-intervals-for-the-standardized-mortality-ratio-in-studies-with-missing-death-certificates
#13
Jana Timkova, Lukas Kotik, Ladislav Tomasek
This paper assesses the coverage probability of commonly used confidence intervals for the standardized mortality ratio (SMR) when death certificates are missing. It also proposes alternative confidence interval approaches with coverage probabilities close to .95. In epidemiology, the SMR is an important measure of risk of disease mortality (or incidence) to compare a specific group to a reference population. The appropriate confidence interval for the SMR is crucial, especially when the SMR is close to 1.0 and the statistical significance of the risk needs to be determined...
August 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28760388/baseline-evaluation-for-natural-radioactivity-level-and-radiological-hazardous-parameters-associated-with-processing-of-high-grade-monazite
#14
E M El Afifi, A M Shahr El-Din, R F Aglan, E H Borai, M M Abo-Aly
Egyptian monazite is a promising resource and investment attractive for production of valuable metals of industrial or nuclear interest such as rare earth elements (REEs), thorium (Th) and uranium (U). The study was focused to establish a baseline framework in viewpoint of radiation protection for the workers in production of REEs from high-grade monazite treated by sodium hydroxide (NaOH) solutions. Radiological hazard indices (cancer, gonadal and other risks) were evaluated, due to emissions (α-, β- and γ-radiations) of radium-isotopes ((228)Ra, (226)Ra, (223)Ra) and lead ((210)Pb)...
July 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28697062/morbidity-and-health-risk-factors-among-new-mexico-miners-a-comparison-across-mining-sectors
#15
Alice M Shumate, Kristin Yeoman, Tristan Victoroff, Kandace Evans, Roger Karr, Tami Sanchez, Akshay Sood, Anthony Scott Laney
OBJECTIVE: This study examines differences in chronic health outcomes between coal, uranium, metal, and nonmetal miners. METHODS: In a cross-sectional study using data from a health screening program for current and former New Mexico miners, log-binomial logistic regression models were used to estimate relative risks of respiratory and heart disease, cancer, osteoarthritis, and back pain associated with mining in each sector as compared with coal, adjusting for other relevant risk factors...
August 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28655165/investigation-of-natural-radioactivity-as-a-possible-driver-of-cancer-incidence-in-para%C3%A3-ba-northeastern-brazil
#16
Josineide Marques do Nascimento Santos, José Araújo Dos Santos Júnior, Ana Maria Mendoça de Albuquerque Melo, Romilton Dos Santos Amaral, Rômulo Simões Cezar Menezes, Zahily Herrero Fernández, Lino Angel Valcárcel Rojas, Jairo Dias Bezerra, Alberto Antônio da Silva, Kennedy Francys Rodrigues Damascena, Nilson Vicente da Silva Medeiros
An increase of health problems has been reported in the city of Triunfo, Paraíba, NE Brazil. This pattern has been attributed to environmental radiation since there are uranium deposits in the neighboring municipalities. The present study aimed to carry a radiometric survey in Triunfo to determine effective dose from external outdoor radiation exposure. The results were obtained through 'in situ' measurements using a gamma spectrometry system. The results ranged from 0.06 to 0.38 mSv/y, mean of 0.20 mSv/y...
January 1, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28520643/risk-of-lung-cancer-mortality-in-nuclear-workers-from-internal-exposure-to-alpha-particle-emitting-radionuclides
#17
James Grellier, Will Atkinson, Philippe Bérard, Derek Bingham, Alan Birchall, Eric Blanchardon, Richard Bull, Irina Guseva Canu, Cécile Challeton-de Vathaire, Rupert Cockerill, Minh T Do, Hilde Engels, Jordi Figuerola, Adrian Foster, Luc Holmstock, Christian Hurtgen, Dominique Laurier, Matthew Puncher, Anthony E Riddell, Eric Samson, Isabelle Thierry-Chef, Margot Tirmarche, Martine Vrijheid, Elisabeth Cardis
BACKGROUND: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. METHODS: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and plutonium workers...
September 2017: Epidemiology
https://www.readbyqxmd.com/read/28508337/natural-radionuclide-dose-and-lifetime-cancer-risk-due-to-ingestion-of-fish-and-water-from-fresh-water-reservoirs-near-the-proposed-uranium-mining-site
#18
Sathesh Kumar Annamalai, Kantha Deivi Arunachalam, Rajaram Selvaraj
Ten sampling locations in Nagarjuna Sagar Dam have been selected to assess the suitability of the reservoir water for human consumption. The sediment, water, and fish samples were collected and analyzed for radionuclide (238 U,232 Th,210 Po,226 Ra,210 Pb) and physicochemical parameters like pH, TOC, total hardness, alkalinity, DO, cation exchange capacity, and particle size. The spatial variations among the radionuclides (238 U,232 Th,210 Po,226 Ra,210 Pb) in water and bottom sediments of Nagarjuna Sagar Dam were determined...
June 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28462701/depleted-uranium-and-human-health
#19
REVIEW
Armando Faa, Clara Gerosa, Daniela Fanni, Giuseppe Floris, Peter V Eyken, Joanna I Lachowicz, Valeria M Nurchi
Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized...
2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28443719/influence-of-quartz-exposure-on-lung-cancer-types-in-cases-of-lymph-node-only-silicosis-and-lung-silicosis-in-german-uranium-miners
#20
Stefan Mielke, Dirk Taeger, Kerstin Weitmann, Thomas Brüning, Wolfgang Hoffmann
Inhaled crystalline quartz is a carcinogen. Analyses show differences in the distribution of lung cancer types depending on the status of silicosis. Using 2,524 lung tumor cases from the WISMUT autopsy repository database, silicosis was differentiated into cases without silicosis in lung parenchyma and its lymph nodes, with lymph node-only silicosis, or with lung silicosis including lymph node silicosis. The proportions of adenocarcinoma, squamous cell carcinoma, and small-cell lung carcinoma mortality for increasing quartz exposures were estimated in a multinomial logistic regression model...
April 26, 2017: Archives of Environmental & Occupational Health
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