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https://www.readbyqxmd.com/read/27577748/cross-over-efficiency-comparison-of-different-tidal-automated-peritoneal-dialysis-schedules
#1
Alessandro Domenici, Anna Giuliani, Francesca Sivo, Clorinda Falcone, Giorgio Punzo, Paolo Menè
This study compares 5 different tidal automated peritoneal dialysis (APD) prescriptions. Six low-average and 6 high-average transporters performed 3 separate sessions with 5 different schedules: (A) 50% tidal with initial fill volume (FV) 2 liters, (B) 50% tidal with 2.2 liters initial FV, (C) 2.2 liters initial FV with 70% tidal, (D) as in B, with one complete renewal of the initial FV at midsession, (E) 2.2 liters FV with breakpoint modality. Urea, creatinine and phosphate peritoneal clearances, sodium removal and ultrafiltration (UF) were compared using analysis of variance...
August 30, 2016: Blood Purification
https://www.readbyqxmd.com/read/27566866/histological-effects-of-givinostat-in-boys-with-duchenne-muscular-dystrophy
#2
Paolo Bettica, Stefania Petrini, Valentina D'Oria, Adele D'Amico, Michela Catteruccia, Marika Pane, Serena Sivo, Francesca Magri, Simona Brajkovic, Sonia Messina, Gian Luca Vita, Barbara Gatti, Maurizio Moggio, Pier Lorenzo Puri, Maurizio Rocchetti, Giuseppe De Nicolao, Giuseppe Vita, Giacomo P Comi, Enrico Bertini, Eugenio Mercuri
Duchenne Muscular Dystrophy (DMD) is caused by mutations in the dystrophin gene leading to dystrophin deficiency, muscle fiber degeneration and progressive fibrotic replacement of muscles. Givinostat, a histone deacetylase (HDAC) inhibitor, significantly reduced fibrosis and promoted compensatory muscle regeneration in mdx mice. This study was conducted to evaluate whether the beneficial histological effects of Givinostat could be extended to DMD boys. Twenty ambulant DMD boys aged 7 to <11 years on stable corticosteroid treatment were enrolled in the study and treated for ≥12 months with Givinostat...
October 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27494024/revised-north-star-ambulatory-assessment-for-young-boys-with-duchenne-muscular-dystrophy
#3
Eugenio Mercuri, Giorgia Coratti, Sonia Messina, Valeria Ricotti, Giovanni Baranello, Adele D'Amico, Maria Carmela Pera, Emilio Albamonte, Serena Sivo, Elena Stacy Mazzone, Maria Teresa Arnoldi, Lavinia Fanelli, Roberto De Sanctis, Domenico M Romeo, Gian Luca Vita, Roberta Battini, Enrico Bertini, Francesco Muntoni, Marika Pane
The advent of therapeutic approaches for Duchenne muscular dystrophy (DMD) has highlighted the need to identify reliable outcome measures for young boys with DMD. The aim of this study was to develop a revised version of the North Star Ambulatory Assessment (NSAA) suitable for boys between the age of 3 and 5 years by identifying age appropriate items and revising the scoring system accordingly. Using the scale in 171 controls between the age of 2.9 and 4.8 years, we identified items that were appropriate at different age points...
2016: PloS One
https://www.readbyqxmd.com/read/26776503/patterns-of-disease-progression-in-type-2-and-3-sma-implications-for-clinical-trials
#4
Eugenio Mercuri, Richard Finkel, Jacqueline Montes, Elena S Mazzone, Maria Pia Sormani, Marion Main, Danielle Ramsey, Anna Mayhew, Allan M Glanzman, Sally Dunaway, Rachel Salazar, Amy Pasternak, Janet Quigley, Marika Pane, Maria Carmela Pera, Mariacristina Scoto, Sonia Messina, Maria Sframeli, Gian Luca Vita, Adele D'Amico, Marleen van den Hauwe, Serena Sivo, Nathalie Goemans, Petra Kaufmann, Basil T Darras, Enrico Bertini, Francesco Muntoni, Darryl C De Vivo
The aim of the study was to establish 12-month changes in the Hammersmith Functional motor scale in a large cohort of SMA patients, to identify patterns of disease progression and the effect of different variables. 268 patients were included in this multicentric study. Their age ranged between 2.5 and 55.5 years at baseline, 68 were ambulant and 200 non-ambulant. The baseline scores ranged between 0 and 66 (mean 23.91, SD 20.09). The 12-month change was between -14 and +9 (mean -0.56, SD 2.72). Of the 268 patients, 206 (76...
February 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/26636671/correction-long-term-natural-history-data-in-ambulant-boys-with-duchenne-muscular-dystrophy-36-month-changes
#5
Marika Pane, Elena Stacy Mazzone, Serena Sivo, Maria Pia Sormani, Sonia Messina, Adele D'Amico, Adelina Carlesi, Gianluca Vita, Lavinia Fanelli, Angela Berardinelli, Yvan Torrente, Valentina Lanzillotta, Emanuela Viggiano, Paola D'Ambrosio, Filippo Cavallaro, Silvia Frosini, Andrea Barp, Serena Bonfiglio, Roberta Scalise, Roberto De Sanctis, Enrica Rolle, Alessandra Graziano, Francesca Magri, Concetta Palermo, Francesca Rossi, Maria Alice Donati, Michele Sacchini, Maria Teresa Arnoldi, Giovanni Baranello, Tiziana Mongini, Antonella Pini, Roberta Battini, Elena Pegoraro, Stefano Previtali, Claudio Bruno, Luisa Politano, Giacomo P Comi, Enrico Bertini, Eugenio Mercuri
No abstract text is available yet for this article.
2015: PloS One
https://www.readbyqxmd.com/read/26248957/benefits-of-glucocorticoids-in-non-ambulant-boys-men-with-duchenne-muscular-dystrophy-a-multicentric-longitudinal-study-using-the-performance-of-upper-limb-test
#6
MULTICENTER STUDY
Marika Pane, Lavinia Fanelli, Elena Stacy Mazzone, Giorgia Olivieri, Adele D'Amico, Sonia Messina, Marianna Scutifero, Roberta Battini, Roberta Petillo, Silvia Frosini, Serena Sivo, Gian Luca Vita, Claudio Bruno, Tiziana Mongini, Elena Pegoraro, Roberto De Sanctis, Alice Gardani, Angela Berardinelli, Valentina Lanzillotta, Adelina Carlesi, Emanuela Viggiano, Filippo Cavallaro, Maria Sframeli, Luca Bello, Andrea Barp, Flaviana Bianco, Serena Bonfiglio, Enrica Rolle, Concetta Palermo, Grazia D'Angelo, Antonella Pini, Elena Iotti, Ksenija Gorni, Giovanni Baranello, Enrico Bertini, Luisa Politano, Maria Pia Sormani, Eugenio Mercuri
The aim of this study was to establish the possible effect of glucocorticoid treatment on upper limb function in a cohort of 91 non-ambulant DMD boys and adults of age between 11 and 26 years. All 91 were assessed using the Performance of Upper Limb test. Forty-eight were still on glucocorticoid after loss of ambulation, 25 stopped steroids at the time they lost ambulation and 18 were GC naïve or had steroids while ambulant for less than a year. At baseline the total scores ranged between 0 and 74 (mean 41...
October 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/26111847/old-measures-and-new-scores-in-spinal-muscular-atrophy-patients
#7
Elena Mazzone, Jacqueline Montes, Marion Main, Anna Mayhew, Danielle Ramsey, Allan M Glanzman, Sally Dunaway, Rachel Salazar, Amy Pasternak, Janet Quigley, Marika Pane, Maria C Pera, Mariacristina Scoto, Sonia Messina, Maria Sframeli, Adele D'amico, Marleen Van Den Hauwe, Serena Sivo, Nathalie Goemans, Basil T Darras, Petra Kaufmann, Enrico Bertini, Darryl C De Vivo, Francesco Muntoni, Richard Finkel, Eugenio Mercuri
INTRODUCTION: A recent Rasch analysis performed on the Hammersmith Functional Motor Scale-Expanded (HFMSE) in patients with spinal muscular atrophy (SMA) identified issues impacting scale validity, redundant items, and disordered thresholds on some items. METHODS: We modified the HMFSE scoring based on the Rasch analysis and on expert consensus to establish whether the traditional scoring overestimated the number of patients with changes within 2 points from baseline...
September 2015: Muscle & Nerve
https://www.readbyqxmd.com/read/26058340/-is-there-vitamin-d-deficiency-in-children-in-a-sunny-mediterranean-city
#8
A Togo, D Espadas Maciá, S Blanes Segura, N Sivó Díaz, C Villalba Martínez
INTRODUCTION: Despite the increasing interest in vitamin D functions, new cases of deficiency have been reported in sunny regions where optimal levels are expected. The aim of this study was to analyze 25-hydroxivitamin D levels in children younger than 2 years admitted for acute mild diseases in a tertiary hospital in Valencia and its relationship with factors that can be associated with its deficiency. METHODS: This one year prospective and observational study was conducted on 169 children admitted for acute mild diseases...
March 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/25642376/the-6-minute-walk-test-and-performance-of-upper-limb-in-ambulant-duchenne-muscular-dystrophy-boys
#9
Marika Pane, Elena Stacy Mazzone, Serena Sivo, Lavinia Fanelli, Roberto De Sanctis, Adele D'Amico, Sonia Messina, Roberta Battini, Flaviana Bianco, Marianna Scutifero, Roberta Petillo, Silvia Frosini, Roberta Scalise, Gian Luca Vita, Claudio Bruno, Marina Pedemonte, Tiziana Mongini, Elena Pegoraro, Francesca Brustia, Alice Gardani, Angela Berardinelli, Valentina Lanzillotta, Emanuela Viggiano, Filippo Cavallaro, Maria Sframeli, Luca Bello, Andrea Barp, Fabio Busato, Serena Bonfiglio, Enrica Rolle, Giulia Colia, Annamaria Bonetti, Concetta Palermo, Alessandra Graziano, Grazia D'Angelo, Antonella Pini, Alice Corlatti, Ksenija Gorni, Giovanni Baranello, Laura Antonaci, Enrico Bertini, Luisa Politano, Eugenio Mercuri
The Performance of Upper Limb (PUL) test was specifically developed for the assessment of upper limbs in Duchenne muscular dystrophy (DMD). The first published data have shown that early signs of involvement can also be found in ambulant DMD boys. The aim of this longitudinal Italian multicentric study was to evaluate the correlation between the 6 Minute Walk Test (6MWT) and the PUL in ambulant DMD boys. Both 6MWT and PUL were administered to 164 ambulant DMD boys of age between 5.0 and 16.17 years (mean 8...
2014: PLoS Currents
https://www.readbyqxmd.com/read/25500010/upper-limb-module-in-non-ambulant-patients-with-spinal-muscular-atrophy-12-month-changes
#10
Serena Sivo, Elena Mazzone, Laura Antonaci, Roberto De Sanctis, Lavinia Fanelli, Concetta Palermo, Jacqueline Montes, Marika Pane, Eugenio Mercuri
Recent studies have suggested that in non-ambulant patients affected by spinal muscular atrophy the Upper Limb Module can increase the range of activities assessed by the Hammersmith Functional Motor Scale Expanded. The aim of this study was to establish 12-month changes in the Upper Limb Module in a cohort of non-ambulant spinal muscular atrophy patients and their correlation with changes on the Hammersmith Functional Motor Scale Expanded. The Upper Limb Module scores ranged between 0 and 17 (mean 10.23, SD 4...
March 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25454732/suitability-of-north-star-ambulatory-assessment-in-young-boys-with-duchenne-muscular-dystrophy
#11
MULTICENTER STUDY
Roberto De Sanctis, Marika Pane, Serena Sivo, Valeria Ricotti, Giovanni Baranello, Silvia Frosini, Elena Mazzone, Flaviana Bianco, Lavinia Fanelli, Marion Main, Alice Corlatti, Adele D'Amico, Giulia Colia, Roberta Scalise, Concetta Palermo, Chiara Alfonsi, Giovanna Tritto, Domenico M Romeo, Alessandra Graziano, Roberta Battini, Lucia Morandi, Enrico Bertini, Francesco Muntoni, Eugenio Mercuri
The aim of this study was to establish the suitability of the North Star Ambulatory Assessment for use in young boys with Duchenne muscular dystrophy. We studied 147 typically developing and 144 boys affected by Duchenne muscular dystrophy between the ages of 3 and 5 years. More than 85% of the typically developing boys by the age of 4 years had full scores on all the items with total scores ≥33/34. Before the age of 4 years more than 15% of the typically developing boys did not achieve full scores on all the items...
January 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25321824/first-on-sky-scao-validation-of-full-lqg-control-with-vibration-mitigation-on-the-canary-pathfinder
#12
Gaetano Sivo, Caroline Kulcsár, Jean-Marc Conan, Henri-François Raynaud, Eric Gendron, Alastair Basden, Fabrice Vidal, Tim Morris, Serge Meimon, Cyril Petit, Damien Gratadour, Olivier Martin, Zoltan Hubert, Arnaud Sevin, Denis Perret, Fanny Chemla, Gérard Rousset, Nigel Dipper, Gordon Talbot, Eddy Younger, Richard Myers, David Henry, Stephen Todd, David Atkinson, Colin Dickson, Andy Longmore
Adaptive optics provides real time correction of wavefront disturbances on ground based telescopes. Optimizing control and performance is a key issue for ever more demanding instruments on ever larger telescopes affected not only by atmospheric turbulence, but also by vibrations, windshake and tracking errors. Linear Quadratic Gaussian control achieves optimal correction when provided with a temporal model of the disturbance. We present in this paper the first on-sky results of a Kalman filter based LQG control with vibration mitigation on the CANARY instrument at the Nasmyth platform of the 4...
September 22, 2014: Optics Express
https://www.readbyqxmd.com/read/25274841/lmna-associated-myopathies-the-italian-experience-in-a-large-cohort-of-patients
#13
Lorenzo Maggi, Adele D'Amico, Antonella Pini, Serena Sivo, Marika Pane, Giulia Ricci, Liliana Vercelli, Paola D'Ambrosio, Lorena Travaglini, Simone Sala, Greta Brenna, Dimos Kapetis, Marina Scarlato, Elena Pegoraro, Maurizio Ferrari, Antonio Toscano, Sara Benedetti, Pia Bernasconi, Lara Colleoni, Giovanna Lattanzi, Enrico Bertini, Eugenio Mercuri, Gabriele Siciliano, Carmelo Rodolico, Tiziana Mongini, Luisa Politano, Stefano C Previtali, Nicola Carboni, Renato Mantegazza, Lucia Morandi
OBJECTIVES: Our aim was to conduct a comparative study in a large cohort of myopathic patients carrying LMNA gene mutations to evaluate clinical and molecular features associated with different phenotypes. METHODS: We performed a retrospective cohort study of 78 myopathic patients with LMNA mutation and 30 familial cases with LMNA mutation without muscle involvement. We analyzed features characterizing the various forms of LMNA-related myopathy through correlation statistics...
October 28, 2014: Neurology
https://www.readbyqxmd.com/read/25271887/long-term-natural-history-data-in-ambulant-boys-with-duchenne-muscular-dystrophy-36-month-changes
#14
MULTICENTER STUDY
Marika Pane, Elena Stacy Mazzone, Serena Sivo, Maria Pia Sormani, Sonia Messina, Adele D'Amico, Adelina Carlesi, Gianluca Vita, Lavinia Fanelli, Angela Berardinelli, Yvan Torrente, Valentina Lanzillotta, Emanuela Viggiano, Paola D Ambrosio, Filippo Cavallaro, Silvia Frosini, Andrea Barp, Serena Bonfiglio, Roberta Scalise, Roberto De Sanctis, Enrica Rolle, Alessandra Graziano, Francesca Magri, Concetta Palermo, Francesca Rossi, Maria Alice Donati, Michele Sacchini, Maria Teresa Arnoldi, Giovanni Baranello, Tiziana Mongini, Antonella Pini, Roberta Battini, Elena Pegoraro, Stefano Previtali, Claudio Bruno, Luisa Politano, Giacomo P Comi, Enrico Bertini, Eugenio Mercuri
The 6 minute walk test has been recently chosen as the primary outcome measure in international multicenter clinical trials in Duchenne muscular dystrophy ambulant patients. The aim of the study was to assess the spectrum of changes at 3 years in the individual measures, their correlation with steroid treatment, age and 6 minute walk test values at baseline. Ninety-six patients from 11 centers were assessed at baseline and 12, 24 and 36 months after baseline using the 6 minute walk test and the North Star Ambulatory Assessment...
2014: PloS One
https://www.readbyqxmd.com/read/25251337/inhibition-of-cellular-proliferation-and-enhancement-of-hydrogen-peroxide-production-in-fibrosarcoma-cell-line-by-weak-radio-frequency-magnetic-fields
#15
Pablo R Castello, Iain Hill, Frank Sivo, Lucas Portelli, Frank Barnes, Robert Usselman, Carlos F Martino
This study presents experimental data for the effects of weak radio frequency (RF) magnetic fields on hydrogen peroxide (H2O2) production and cellular growth rates of fibrosarcoma HT1080 cells in vitro. Cells were exposed either to 45 µT static magnetic fields (SMFs)-oriented vertical to the plane of growth or to SMFs combined with weak 5 and 10 MHz RF magnetic fields of 10 µTRMS intensity perpendicular to the static field. Cell numbers were reduced up to 30% on Day 2 for the cells exposed to the combination of SMF and a 10 MHz RF magnetic field compared with the SMF control cells...
December 2014: Bioelectromagnetics
https://www.readbyqxmd.com/read/25173651/longitudinal-assessment-of-perceptual-motor-abilities-in-pre-school-preterm-children
#16
Claudia Brogna, Paola De Rose, Serena Sivo, Valentina Laganà, Alessandra Graziano, Chiara Alfonsi, Emilio Albamonte, Francesca Gallini, Francesca Serrao, Domenico M Romeo, Simonetta Frezza, Patrizia Papacci, Costantino Romagnoli, Eugenio Mercuri, Daniela Ricci
OBJECTIVE: To verify the value of early perceptual-motor assessment in preterms. METHODS: The M-ABC2 was performed below the age 3 years-4 months and 1 year later. RESULTS: At 4 years children showed a significant improvement in the scores and reduced rate of refusals. CONCLUSION: Early findings may be related to delayed maturation.
October 2014: Early Human Development
https://www.readbyqxmd.com/read/25091533/sleep-disturbances-in-preschool-age-children-with-cerebral-palsy-a-questionnaire-study
#17
Domenico M Romeo, Claudia Brogna, Elisa Musto, Giovanni Baranello, Emanuela Pagliano, Tiziana Casalino, Daniela Ricci, Maria Mallardi, Serena Sivo, Francesco Cota, Domenica Battaglia, Oliviero Bruni, Eugenio Mercuri
OBJECTIVES: The study aimed to analyze (i) the prevalence of sleep disorders in pre-school children with cerebral palsy (CP) using the Sleep Disturbance Scale for Children (SDSC), (ii) the possible association with motor, cognitive and behavioral problems, and (iii) the possible differences with typically developing children matched for age and gender. METHODS: One-hundred children with CP (age range: 3-5 years, mean: 3.8 years) were assessed using the SDSC, the Gross Motor Function Classification System (GMFCS), the Wechsler Preschool and Primary Scale of Intelligence, and the Child Behaviour Check List (CBCL) to assess sleep, motor, cognitive, and behavioral problems, respectively...
September 2014: Sleep Medicine
https://www.readbyqxmd.com/read/24440357/reliability-of-the-performance-of-upper-limb-assessment-in-duchenne-muscular-dystrophy
#18
Marika Pane, Elena S Mazzone, Lavinia Fanelli, Roberto De Sanctis, Flaviana Bianco, Serena Sivo, Adele D'Amico, Sonia Messina, Roberta Battini, Marianna Scutifero, Roberta Petillo, Silvia Frosini, Roberta Scalise, Gianluca Vita, Claudio Bruno, Marina Pedemonte, Tiziana Mongini, Elena Pegoraro, Francesca Brustia, Alice Gardani, Angela Berardinelli, Valentina Lanzillotta, Emanuela Viggiano, Filippo Cavallaro, Maria Sframeli, Luca Bello, Andrea Barp, Serena Bonfiglio, Enrica Rolle, Giulia Colia, Michela Catteruccia, Concetta Palermo, Grazia D'Angelo, Antonella Pini, Elena Iotti, Ksenija Gorni, Giovanni Baranello, Lucia Morandi, Enrico Bertini, Luisa Politano, MariaPia Sormani, Eugenio Mercuri
The Performance of Upper Limb was specifically designed to assess upper limb function in Duchenne muscular dystrophy. The aim of this study was to assess (1) a cohort of typically developing children from the age of 3years onwards in order to identify the age when the activities assessed in the individual items are consistently achieved, and (2) a cohort of 322 Duchenne children and young adults to establish the range of findings at different ages. We collected normative data for the scale validation on 277 typically developing subjects from 3 to 25years old...
March 2014: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/24424102/sleep-disorders-in-children-with-cerebral-palsy-neurodevelopmental-and-behavioral-correlates
#19
Domenico M Romeo, Claudia Brogna, Michela Quintiliani, Giovanni Baranello, Emanuela Pagliano, Tiziana Casalino, Annalisa Sacco, Daniela Ricci, Maria Mallardi, Elisa Musto, Serena Sivo, Francesco Cota, Domenica Battaglia, Oliviero Bruni, Eugenio Mercuri
OBJECTIVES: We aimed to estimate the frequency of sleep disorders in children with cerebral palsy (CP) using the Sleep Disturbance Scale for Children (SDSC) and to evaluate the relations between sleep disorders and motor, cognitive, and behavioral problems. METHODS: One hundred and sixty-five children with CP ages 6-16 years (mean age, 11years) were assessed using the SDSC, the Gross Motor Function Classification System (GMFCS), the Wechsler Intelligence Scale for Children and the Child Behavior Check List (CBCL) to assess sleep, motor, cognitive, and behavioral problems, respectively...
February 2014: Sleep Medicine
https://www.readbyqxmd.com/read/23870751/perceptual-motor-abilities-in-pre-school-preterm-children
#20
Paola De Rose, Emilio Albamonte, Valentina Laganà, Serena Sivo, Silvia Pisoni, Francesca Gallini, Francesca Serrao, Francesca Tinelli, Giulia Purpura, Alessandra Ometto, Annalisa Sacco, Michela Quintiliani, Valentina De Clemente, Alessandra Graziano, Domenico M Romeo, Simona Frezza, Patrizia Papacci, Fabio Mosca, Stefano Vicari, Luca A Ramenghi, Giovanni Cioni, Costantino Romagnoli, Eugenio Mercuri, Daniela Ricci
BACKGROUND: Several studies report a high percentage of premature infants presenting perceptual motor difficulties at school age. The new version of the Movement Assessment Battery for Children allows the assessment of perceptual-motor abilities in children from the age of 3years. AIMS: To evaluate early perceptual-motor abilities in prematurely born children below the age of 4years. STUDY DESIGN: The Movement Assessment Battery for Children 2nd edition was administered to 105 low-risk prematurely born children (<32weeks gestation) and in a control group of 105 term-born children matched for age and sex...
October 2013: Early Human Development
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