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JOURNAL ARTICLE
Hiroshi Taniwaki, Masatoshi Hoshino, Yuki Kinoshita, Akira Matsumura, Takashi Namikawa, Minori Kato, Shinji Takahashi, Hiroaki Nakamura
OBJECTIVE: Hounsfield Unit (HU) value has been associated with future osteoporotic fractures and postoperative complications. However, no studies on the impact of low HU values on mid-term clinical outcomes following lumbar spine surgery have been reported. We aimed to evaluate the usefulness of preoperative HU values for 5-year clinical outcomes following lumbar spine surgery. METHODS: We enrolled 200 patients who underwent lumbar surgery (≤ 3-disc levels) for lumbar spinal stenosis...
October 26, 2023: European Spine Journal
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JOURNAL ARTICLE
M D Shanker, A Cavazos, J Li, T Beckham, D N Yeboa, C Wang, M F McAleer, T M Briere, B Amini, C Tatsui, R North, C Alvarez-Breckenridge, P Cezayirli, L D Rhines, A J Ghia, A J Bishop
PURPOSE/OBJECTIVE(S): Sarcoma spinal metastases (SSM) are particularly difficult to manage given their poor response rates to chemotherapy and their inherent radioresistance. We sought to analyze dosimetric parameters impacting local failure and vertebral compression fracture outcomes in a homogenously treated cohort of patients with SSM treated with single-fraction spine stereotactic radiosurgery (SSRS). MATERIALS/METHODS: A retrospective review was conducted on a cohort of patients with SSM treated with definitive SSRS at a single tertiary institution...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
D M Palhares, K L Zeng, S D Myrehaug, C L Tseng, H Soliman, H Chen, P Maralani, J Larouche, J Wilson, M E Ruschin, B Zhang, E Atenafu, A Sahgal, J Detsky
PURPOSE/OBJECTIVE(S): A international consensus recommendation was published to guide target volume delineation specific to sacral stereotactic body radiotherapy (SBRT). We report outcomes after sacrum SBRT, focusing on the impact of contouring deviation on local failure (LF) risk, with an aim to validate this guideline. MATERIALS/METHODS: All patients who underwent SBRT to any level between S1 and S5 from 2010 to 2021 were identified from a prospectively maintained institutional database...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Chih-Kun Hsiao, Hao-Yuan Hsiao, Yi-Jung Tsai, Chao-Ming Hsu, Yuan-Kun Tu
Spinal fusion surgery leads to the restriction of mobility in the vertebral segments postoperatively, thereby causing stress to rise at the adjacent levels, resulting in early degeneration and a high risk of adjacent vertebral fractures. Thus, to address this issue, non-fusion surgery applies some pedicle screw-based dynamic stabilisation systems to provide stability and micromotion, thereby reducing stress in the fusion segments. Among these systems, the hybrid performance stabilisation system (HPSS) combines a rigid rod, transfer screw, and coupler design to offer a semi-rigid fixation method that preserves some mobility near the fusion site and reduces the adjacent segment compensatory effects...
September 5, 2023: Bioengineering
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JOURNAL ARTICLE
Renata Gervais Santa Rosa, Simone Polonine, Alinie Pichone, Carlos Perez Gomes, Luís Felipe Cardoso Lima, Francisco de Paula Paranhos Neto, Laura Maria Carvalho de Mendonça, Maria Lucia Fleiuss Farias, Miguel Madeira
PURPOSE: This cross-sectional study aimed to assess bone mineral density (BMD), bone microarchitecture and fracture prevalence in women with chronic postsurgical hypoparathyroidism (hypoPT). METHODS: Twenty-seven women with postsurgical hypoPT and 44 age-matched healthy women were included. Dual-energy X-ray absorptiometry was used to evaluate areal BMD and vertebral fracture assessment. High-resolution peripheral quantitative computed tomography assessed microarchitecture and volumetric BMD at the distal radius and tibia...
August 25, 2023: Endocrine
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JOURNAL ARTICLE
Anabela Barcelos, Judite Gonçalves, Céu Mateus, Helena Canhão, Ana Maria Rodrigues
UNLABELLED: Osteoporosis-related fractures lead to high morbidity, mortality, and healthcare costs among post-menopausal women. This study showed that incident non-hip osteoporosis-related fractures are frequent among women aged 50 + in Portugal, leading to excessive healthcare costs of €74 million per year, in a conservative scenario. PURPOSE: This study aimed to estimate the costs of incident non-hip osteoporosis-related fractures among postmenopausal women living in Portugal from a payer perspective...
August 19, 2023: Osteoporosis International
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JOURNAL ARTICLE
Xu-Miao Lin, Zhi-Cai Shi
BACKGROUND: Spinal osteoporosis is a prevalent health condition characterized by the thinning of bone tissues in the spine, increasing the risk of fractures. Given its high incidence, especially among older populations, it is critical to have accurate and effective predictive models for fracture risk. Traditionally, clinicians have relied on a combination of factors such as demographics, clinical attributes, and radiological characteristics to predict fracture risk in these patients. However, these models often lack precision and fail to include all potential risk factors...
July 16, 2023: World Journal of Clinical Cases
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REVIEW
Alexandra-Ioana Trandafir, Mihaela Stanciu, Simona Elena Albu, Vasile Razvan Stoian, Irina Ciofu, Cristian Persu, Claudiu Nistor, Mara Carsote
Our aim is to analyse the bone profile in adults with (non-functioning) adrenal incidentalomas (AIs), specifically addressing the impact of autonomous cortisol secretion (ACS). This narrative review, based on a PubMed search from inception to February 2023 (case reports, non-ACS, and other secondary causes of osteoporosis were excluded), included 40 original studies, a total of 3046 patients with female prevalence (female:male ratio of 1921:1125), aged between 20.5 and 95.5 years old. This three decade-based analysis showed that 37 studies provided dual-energy X-ray absorptiometry (DXA) information; another five studies reports results on bone micro-architecture, including trabecular bone score (TBS), spinal deformity index, and high-resolution peripheral quantitative computed tomography; 20 cohorts included data on bone turnover markers (BTMs), while four longitudinal studies followed subjects between 1 and 10...
June 24, 2023: Journal of Clinical Medicine
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JOURNAL ARTICLE
Kenta Minato, Jung-Ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
UNLABELLED: Durin g the first wave of the COVID-19 epidemic, the total number of patients with any of the four major fragility fractures, including both inpatients and first-visit outpatients, began to decline shortly before the state of emergency was declared, rather than immediately after it was declared. PURPOSE: This study aimed to investigate the impact of public health measures in the first wave of the COVID-19 epidemic on the occurrence of major fragility fractures (MFFs)...
June 21, 2023: Archives of Osteoporosis
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JOURNAL ARTICLE
Jimmy Zheng, Paul A Heidenreich, Shun Kohsaka, William F Fearon, Alexander T Sandhu
BACKGROUND: Coronary artery disease (CAD) testing remains underutilized in patients with newly diagnosed heart failure (HF). The longitudinal clinical impact of early CAD testing has not been well-characterized. We investigated changes in clinical management and long-term outcomes after early CAD evaluation in patients with incident HF. METHODS: We identified Medicare patients with incident HF from 2006 to 2018. The exposure variable was early CAD testing within 1 month of initial HF diagnosis...
May 22, 2023: Circulation. Heart Failure
#31
Seoyul Lee, Jeong Hun Kim, Yun Kyung Jeon, Jung Sub Lee, Keunyoung Kim, Sun-Kyung Hwang, Jae Ho Kim, Tae Sik Goh, Yun Hak Kim
CONTEXT: Circulating adipokines and ghrelin affect bone remodeling by regulating the activation and differentiation of osteoblasts and osteoclasts. Although the correlation between adipokines, ghrelin, and bone mineral density (BMD) has been studied over the decades, its correlations are still controversial. Accordingly, an updated meta-analysis with new findings is needed. OBJECTIVE: This study aimed to explore the impact of serum adipokine and ghrelin levels on BMD and osteoporotic fractures through a meta-analysis...
2023: Frontiers in Endocrinology
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JOURNAL ARTICLE
Tao-Wu Gong, Yu-Hang Zhu, Peng-Cheng Zhao, Fan Zhang
BACKGROUND: Placement of a central venous catheter (CVC) is a common procedure for spinal surgery and is relatively safe under ultrasound guidance. CASE PRESENTATION: We report the case of a 56-year-old female who underwent ultrasound-guided placement of an internal jugular vein CVC for fluid replacement during spinal surgery for thoracic vertebral burst compression fracture and multiple rib fractures as a result of a high-altitude fall injury. Hemothorax developed intraoperatively...
April 6, 2023: Journal of Cardiothoracic Surgery
#33
JOURNAL ARTICLE
Michelle Gates, Jennifer Pillay, Megan Nuspl, Aireen Wingert, Ben Vandermeer, Lisa Hartling
BACKGROUND: To inform recommendations by the Canadian Task Force on Preventive Health Care, we reviewed evidence on the benefits, harms, and acceptability of screening and treatment, and on the accuracy of risk prediction tools for the primary prevention of fragility fractures among adults aged 40 years and older in primary care. METHODS: For screening effectiveness, accuracy of risk prediction tools, and treatment benefits, our search methods involved integrating studies published up to 2016 from an existing systematic review...
March 21, 2023: Systematic Reviews
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JOURNAL ARTICLE
Massar Najim Obaid, Nardeen Adnan Berto, Safaa Hashim Radhi
The purpose of this paper is to report on the preparation and improvement of a biocomposite material made from ultra-high molecular weight polyethylene for the replacement of natural discs. Such replacements are necessary due to intervertebral disc degradation as humans age, which can cause persistent pain due to nerve compression and high friction between vertebrae that can lead to vertebral corrosion. The material was shown to have excellent mechanical properties such as self-lubrication, low coefficient of friction, impact strength, and biocompatibility; however, it degraded with time due to wear failure...
February 17, 2023: Journal of Biomaterials Science. Polymer Edition
#35
JOURNAL ARTICLE
Mitesh Lalwala, Bharath Koya, Karan Devane, F Scott Gayzik, Ashley A Weaver
Spinal injuries are a concern for automotive applications, requiring large parametric studies to understand spinal injury mechanisms under complex loading conditions. Finite element computational human body models (e.g. Global Human Body Models Consortium (GHBMC) models) can be used to identify spinal injury mechanisms. However, the existing GHBMC detailed models (with high computational time) or GHBMC simplified models (lacking vertebral fracture prediction capabilities) are not ideal for studying spinal injury mechanisms in large parametric studies...
January 19, 2023: Computer Methods in Biomechanics and Biomedical Engineering
#36
JOURNAL ARTICLE
Gen Inoue, Masayuki Miyagi, Wataru Saito, Eiki Shirasawa, Kentaro Uchida, Naobumi Hosogane, Kei Watanabe, Keiichi Katsumi, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Kenya Nojiri, Satoshi Suzuki, Eijiro Okada, Seiji Ueda, Tomohiro Hikata, Yuta Shiono, Kota Watanabe, Hidetomi Terai, Koji Tamai, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Kazuhide Inage, Toshitaka Yoshii, Shuta Ushio, Haruki Funao, Norihiro Isogai, Katsumi Harimaya, Seiji Okada, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshio Doi, Katsuhito Kiyasu, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Daisuke Sakai, Masahiro Tanaka, Atsushi Kimura, Hirokazu Inoue, Atsushi Nakano, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Kenichiro Kakutani, Takashi Yurube, Kazuyoshi Nakanishi, Masashi Oshima, Hiroshi Uei, Yasuchika Aoki, Masahiko Takahata, Akira Iwata, Hirooki Endo, Shoji Seki, Hideki Murakami, Satoshi Kato, Katsuhito Yoshioka, Michio Hongo, Tetsuya Abe, Toshinori Tsukanishi, Masashi Takaso, Ken Ishii
A retrospective multicenter study. Body mass index (BMI) is recognized as an important determinant of osteoporosis and spinal postoperative outcomes; however, the specific impact of BMI on surgery for osteoporotic vertebral fractures (OVFs) remains inconclusive. This retrospective multicenter study investigated the impact of BMI on clinical outcomes following fusion surgery for OVFs. 237 OVF patients (mean age, 74.3 years; 48 men and 189 women) with neurological symptoms who underwent spinal fusion were included in this study...
December 30, 2022: Medicine (Baltimore)
#37
JOURNAL ARTICLE
Tetsuto Yamaura, Fumihiro Arizumi, Keishi Maruo, Kazuya Kishima, Norichika Yoshie, Tomoyuki Kusukawa, Fumiaki Imamura, Toshiya Tachibana
BACKGROUND: Nutritional status, which is associated with osteoporosis and muscle weakness is considered an important factor in the management of acute osteoporotic vertebral fracture (AOVF). However, few reports have investigated the nutritional status of hospitalized patients with AOVF and the impact of malnutrition on their functional prognosis. This study aimed to evaluate the nutritional status of hospitalized elderly patients with AOVF using the Controlling Nutritional Status (CONUT) score and to determine the usefulness of the CONUT score in predicting their functional prognosis...
December 28, 2022: BMC Geriatrics
#38
JOURNAL ARTICLE
Maria Francesca Birtolo, Simone Antonini, Andrea G Lania, Gherardo Mazziotti
Skeletal fragility with high risk of vertebral fractures (VFs) is an emerging complication of growth hormone (GH) hypersecretion. VFs often coexist with spine arthropathy and both clinical conditions negatively impact on quality of life of acromegalic subjects. Management of spine osteopathy and arthropathy in acromegaly could be challenging since both complications can persist or even progress after biochemical control of disease. This article analyzes the latest evidence about possible pathophysiological links between VFs and spine arthropathy in active and controlled acromegaly, as well as the diagnostic and therapeutic aspects concerning the holistic management of acromegalic osteo-arthropathy...
December 27, 2022: Endocrine
#39
JOURNAL ARTICLE
Kentaro Yamada, Makoto Ieguchi, Shinji Takahashi, Hiroaki Nakamura
INTRODUCTION: Pyogenic vertebral osteomyelitis (PVO) is an uncommon but life-threatening infectious disease. Diffuse idiopathic skeletal hyperostosis (DISH) is an age-related disorder and sometimes problematic in terms of spinal instability or high mortality, especially in cases of DISH-related fracture. Meanwhile, no reports have focused on the impact of DISH on the clinical outcomes after treatment for PVO. We hypothesized that PVO occurring at DISH-related segments might contribute to poor clinical results or high mortality rates...
November 27, 2022: Spine surgery and related research
#40
JOURNAL ARTICLE
Joshua Liaw, Natassja Billich, Kate Carroll, Justine Adams, Monique M Ryan, Eppie M Yiu, Margaret Zacharin, Peter Simm, Zoe E Davidson
INTRODUCTION/AIMS: Boys with Duchenne muscular dystrophy (DMD) are at increased risk of fracture. This study investigated the incidence of fractures, factors contributing to risk of first fracture with emphasis on body-mass-index (BMI), and the impact of fractures on functional capacity in an Australian cohort of boys with DMD. METHODS: A retrospective cohort study included boys with DMD who attended a paediatric neuromuscular clinic from 2011-2018. Information regarding fractures, anthropometry measurements, body composition and functional assessment was collected...
December 7, 2022: Muscle & Nerve
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