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high impact vertebral fractures

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https://www.readbyqxmd.com/read/27736260/r-chop-like-treatment-of-diffuse-large-b-cell-lymphoma-significantly-reduces-ct-assessed-vertebral-bone-density-a-single-center-study-of-111-patients
#1
Pernille Svendsen, Nitesh Shekhrajka, Kasper Lindblad Nielsen, Peter Vestergaard, Mette Østergaard Poulsen, Anders Krog Vistisen, Peter Svenssen Munksgaard, Marianne Tang Severinsen, Paw Jensen, Hans Erik Johnsen, Lasse Hjort Jakobsen, Martin Bøgsted, Jens Brøndum Frøkjær, Tarec Christoffer El-Galaly
Treatment of diffuse large B-cell lymphoma (DLBCL) with R-CHOP(-like) regimens include large cumulative doses of prednisolone. In this retrospective study, we evaluated changes in vertebral bone density (VD) in DLBCL patients by measuring CT-ascertained Hounsfield units (HU) at the L3 level. In total, 111 patients diagnosed from 2007 to 2012 and response assessed following first line treatment were included. Post-treatment VD was significantly reduced to 86% of pretreatment VD on average (p < .001). Neither female sex nor high age (>70 years) were significantly associated with greater post-treatment VD reduction...
October 13, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27622174/osteoporosis-associated-with-chronic-obstructive-pulmonary-disease
#2
REVIEW
Ryo Okazaki, Reiko Watanabe, Daisuke Inoue
Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27543441/profile-and-procedures-for-fractures-among-1323-fracture-patients-from-the-2010-yushu-earthquake-china
#3
Peng Kang, Bihan Tang, Yuan Liu, Xu Liu, Yan Shen, Zhipeng Liu, Hongyang Yang, Lulu Zhang
OBJECTIVES: The injuries caused by earthquakes are often complex and of various patterns. Our study included all fracture inpatients from the Yushu earthquake (1323 in total), to learn more about the incidence and distribution of fractures during earthquakes. METHODS: A retrospective study of the clinical characteristics of hospitalized fracture patients after the 2010 Yushu earthquake was conducted from December 20 to 25, 2010.We reviewed medical records of hospitalized patients who had been evacuated from the Yushu earthquake area between April 14 and June 15, 2010, from 57 hospitals, and also reviewed more than 100 documents assembled from daily medical rescue and disease prevention reports submitted by the frontline rescue organizations...
August 3, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27239407/high-risk-of-fall-poor-physical-function-and-low-grip-strength-in-men-with-fracture-the-strambo-study
#4
Pawel Szulc, Clément Feyt, Roland Chapurlat
BACKGROUND: Several studies assessed the association of prevalent fractures with muscle mass, strength, and physical capacity in men. Clinical impact of these associations is not clear, and they could be influenced by confounders. Our aim was to assess the association of the prevalent fractures with muscle strength, physical function, and the risk of subsequent falls in older men after adjustment for muscle mass and potential confounders. METHODS: In a cohort of 890 men aged 50 and older, we assessed appendicular skeletal muscle mass (ASM) by DXA, grip strength, physical function (chair stands, static, and dynamic balance)...
June 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27162711/teardrop-fracture-following-head-first-impact-in-an-ice-hockey-player-case-report-and-analysis-of-injury-mechanisms
#5
James J Yue, Paul C Ivancic, David L Scott
BACKGROUND: We report a case of a young male athlete who sustained a three column displaced teardrop fracture of the C5 vertebra due to a head-first impact in hockey, suffered neurapraxia, yet made full neurological recovery. This full recovery was in sharp contrast to multiple case series which reported permanent quadriplegia in the vast majority of teardrop fracture patients. We investigate the etiology and biomechanical mechanisms of injury. METHODS: Admission imaging revealed the teardrop fracture which consisted of: a frontal plane fracture which separated an anterior quadrilateral-shaped fragment from the posterior vertebral body; a vertical fracture of the posterior vertebral body in the sagittal plane; and incomplete fractures of the neural arch that initiated superiorly at the anterior aspect of the spinous process and left lamina adjacent to the superior facet...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27124040/impact-of-instrumented-spinal-fusion-on-the-development-of-vertebral-compression-fracture
#6
Yen-Chun Chiu, Tsung-Ting Tsai, Shih-Chieh Yang, Hung-Shu Chen, Yu-Hsien Kao, Yuan-Kun Tu
Instrumented spinal fusion has become one of the most common surgeries for patients with various spinal disorders. Only few studies have reported subsequent vertebral compression fractures (VCFs) after instrumented spinal fusion. The purpose of this study was to evaluate the risk of new VCFs in patients undergoing instrumented spinal fusion.We obtained claims data from the National Health Insurance Research Database of Taiwan and retrospectively reviewed 6949 patients with instrumented spinal fusion as the spinal fusion cohort...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27084648/a-prospective-outcomes-study-of-proton-therapy-for-chordomas-and-chondrosarcomas-of-the-spine
#7
Daniel J Indelicato, Ronny L Rotondo, Dustin Begosh-Mayne, Mark T Scarborough, C Parker Gibbs, Christopher G Morris, William M Mendenhall
PURPOSE: To evaluate the effectiveness of definitive or adjuvant external beam proton therapy on survival in patients with chordomas and chondrosarcomas of the spine. METHODS AND MATERIALS: Between March 2007 and May 2013, 51 patients with a median age of 58 years (range, 22-83 years) with chordoma (n=34) or chondrosarcomas (n=17) of the sacrum (n=21), the cervical spine (n=20), and the thoracolumbar spine (n=10) were treated with external beam proton therapy to a median dose of 70...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/26978130/lupus-and-fractures
#8
Irene E M Bultink, Willem F Lems
PURPOSE OF REVIEW: The article reviews recent advances in the research of fractures in patients with systemic lupus erythematosus (SLE), highlighting their clinical, scientific, and economic impact. RECENT FINDINGS: Recent studies demonstrated an increased incidence of osteoporosis and symptomatic fractures in patients with SLE and age, disease duration, disease severity, and glucocorticoid use are important risk factors. A high prevalence of vertebral fractures was demonstrated, while one in three of these patients has normal bone density, which illustrates the multifactorial cause of fractures in SLE...
July 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/26846776/the-predicted-lifetime-costs-and-health-consequences-of-calcium-and-vitamin-d-supplementation-for-fracture-prevention-the-impact-of-cardiovascular-effects
#9
G Hagen, T Wisløff, I S Kristiansen
UNLABELLED: Some studies indicate that calcium supplementation increases cardiovascular risk. We assessed whether such effects could counterbalance the fracture benefits from supplementation. Accounting for cardiovascular outcomes, calcium may cause net harm and would not be cost-effective. Clinicians may do well considering cardiovascular effects when prescribing calcium supplementation. INTRODUCTION: Accounting for possible cardiovascular effect of calcium and vitamin D supplementation (CaD), the aims of this study were to assess whether CaD on balance would improve population health and to evaluate the cost-effectiveness of such supplementation...
June 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26612468/the-role-of-emergency-radiology-in-spinal-trauma
#10
REVIEW
Gianluigi Guarnieri, Roberto Izzo, Mario Muto
Spinal trauma is very frequent injury with different severity and prognosis varying from asymptomatic condition to temporary neurological dysfunction, focal deficit or fatal event. The major causes of spinal trauma are high- and low-energy fall, traffic accident, sport and blunt impact. The radiologist has a role of great responsibility to establish the presence or absence of lesions, to define the characteristics, to assess the prognostic influence and therefore treatment. Imaging has an important role in the management of spinal trauma...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26495245/vertebral-fracture-assessment-current-research-status-and-application-in-patients-with-kyphoplasty
#11
Efstathios Drampalos, Konstantinos Nikolopoulos, Christos Baltas, Alexia Balanika, Antonis Galanos, Nikolaos Papaioannou, Spyros Pneumaticos
Imaging of the spine is of paramount importance for the recognition of osteoporotic vertebral fractures (VFs), and standard radiography (SR) of the spine is the suggested diagnostic method but is not routinely used because of the cost and radiation exposure considerations. VF assessment (VFA) is an efficient, low radiation method for identifying VFs at the time of bone mineral density (BMD) measurement. Prediction models used to indicate the need for VFA may have little predictive power in subspecialty referral populations such as rheumatologic patients or patients who underwent kyphoplasty...
October 18, 2015: World Journal of Orthopedics
https://www.readbyqxmd.com/read/26384492/factors-determining-the-patients-care-intensity-for-surgeons-and-surgical-nurses-a-conjoint-analysis
#12
Catharina J van Oostveen, Hester Vermeulen, Els J M Nieveen van Dijkum, Dirk J Gouma, Dirk T Ubbink
BACKGROUND: Surgeons and nurses sometimes perceive a high workload on the surgical wards, which may influence admission decisions and staffing policy. This study aimed to explore the relative contribution of various patient and care characteristics to the perceived patients' care intensity and whether differences exist in the perception of surgeons and nurses. METHODS: We invited surgeons and surgical nurses in the Netherlands for a conjoint analysis study through internet and e-mail invitations...
2015: BMC Health Services Research
https://www.readbyqxmd.com/read/26308233/impact-of-aromatase-inhibitor-treatment-on-vertebral-morphology-and-bone-mineral-density-in-postmenopausal-women-with-breast-cancer
#13
Paola Villa, Anna P Lassandro, Inbal D Amar, Lorenzo Vacca, Maria C Moruzzi, Gabriella Ferrandina, Daniela Terribile, Riccardo Masetti, Giovanni Scambia
OBJECTIVE: The aim of this study was to evaluate the impact of aromatase inhibitor (AI) treatment on vertebral morphology by vertebral fracture assessment in postmenopausal women with early-stage breast cancer. METHODS: A clinical cross-sectional study was conducted. A group of 156 postmenopausal women with breast cancer (mean [SD] age, 60.4 [10.1] y; mean [SD] time since menopause, 11.7 [9.2] y) was included in the study. Eighty-two women received AI treatment, whereas 74 women did not...
January 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/26286627/validity-of-parental-recall-of-children-s-fracture-implications-for-investigation-of-childhood-osteoporosis
#14
R J Moon, A Lim, M Farmer, A Segaran, N M P Clarke, N C Harvey, C Cooper, J H Davies
UNLABELLED: Fracture history is an important component of osteoporosis diagnosis in children. One in six parentally reported lifetime fractures in children were not confirmed on review of radiographs. Care should be taken to avoid unnecessary investigations for possible osteoporosis due to parental over-reporting of soft tissue injuries as fractures. INTRODUCTION: The diagnosis of osteoporosis in children requires either a vertebral compression fracture, or a significant fracture history (defined as ≥2 long bone fractures <10 years or ≥3 long bone fractures <19 years, excluding high impact fractures) and low bone mineral density...
February 2016: Osteoporosis International
https://www.readbyqxmd.com/read/26160273/biomechanical-modelling-of-impact-related-fracture-characteristics-and-injury-patterns-of-the-cervical-spine-associated-with-riding-accidents
#15
S Y Jauch, S Wallstabe, K Sellenschloh, D Rundt, K Püschel, M M Morlock, N M Meenen, G Huber
BACKGROUND: Horse-related injuries are manifold and can involve the upper and lower limbs, the trunk, spine or head. Cervical spine injuries are not among the most common injuries. However, they can be fatal and often result in neurological symptoms. This study investigated the influence of the posture of the cervical spine on the ultimate strength and the pattern of vertebrae failure with the aim to provide some guidance for protective clothing design. METHODS: Eighteen human cervical spines, each divided into two specimens (three vertebrae each), were subjected to a simulator test designed to mimic a spinal trauma in different postures of the specimen (neutral, flexion, extension)...
October 2015: Clinical Biomechanics
https://www.readbyqxmd.com/read/26106365/early-trabecular-development-in-human-vertebrae-overproduction-constructive-regression-and-refinement
#16
Frank Acquaah, Katharine A Robson Brown, Farah Ahmed, Nathan Jeffery, Richard L Abel
Early bone development may have a significant impact upon bone health in adulthood. Bone mineral density (BMD) and bone mass are important determinants of adult bone strength. However, several studies have shown that BMD and bone mass decrease after birth. If early development is important for strength, why does this reduction occur? To investigate this, more data characterizing gestational, infant, and childhood bone development are needed in order to compare with adults. The aim of this study is to document early vertebral trabecular bone development, a key fragility fracture site, and infer whether this period is important for adult bone mass and structure...
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/26021761/vertebral-scheuermann-s-disease-in-europe-prevalence-geographic-variation-and-radiological-correlates-in-men-and-women-aged-50-and-over
#17
MULTICENTER STUDY
G Armbrecht, D Felsenberg, M Ganswindt, M Lunt, S K Kaptoge, K Abendroth, A Aroso, D Banzer, A K Bhalla, J Dequeker, R Eastell, K Hoszowski, G Lyritis, P D Delmas, P Masaryk, T Miazgowski, J Cannata, R Nuti, L Oei, G Poor, I Redlund-Johnell, D M Reid, W Reisinger, H Schatz, C J Todd, A D Woolf, K Javaid, F Rivadeneira, A J Silman, C Cooper, T W O'Neill, J Reeve
UNLABELLED: In 27 centres across Europe, the prevalence of deforming spinal Scheuermann's disease in age-stratified population-based samples of over 10,000 men and women aged 50+ averaged 8% in each sex, but was highly variable between centres. Low DXA BMD was un-associated with Scheuermann's, helping the differential diagnosis from osteoporosis. INTRODUCTION: This study aims to assess the prevalence of Scheuermann's disease of the spine across Europe in men and women over 50 years of age, to quantitate its association with bone mineral density (BMD) and to assess its role as a confounder for the radiographic diagnosis of osteoporotic fracture...
October 2015: Osteoporosis International
https://www.readbyqxmd.com/read/25972904/the-impact-of-fragility-fractures-on-health-related-quality-of-life-in-patients-with-primary-sclerosing-cholangitis
#18
Joanna Raszeja-Wyszomirska, Robert Kucharski, Marta Zygmunt, Krzysztof Safranow, Tomasz Miazgowski
BACKGROUND: Osteoporosis occurs frequently in patients with chronic cholestatic liver diseases, yet data are scarce regarding the prevalence of osteoporosis and fragility fractures and their impact on Health-Related Quality of Life (HRQoL) in Primary Sclerosing Cholangitis (PSC). OBJECTIVES: We aimed to assess Bone Mineral Density (BMD), physical activity and incidence of fragility fractures in patients with PSC. We also sought associations between prior fractures and HRQoL...
April 2015: Hepatitis Monthly
https://www.readbyqxmd.com/read/25944496/assessment-of-radiological-vertebral-fractures-in-hiv-infected-patients-clinical-implications-and-predictive-factors
#19
L Gazzola, A Savoldi, F Bai, A Magenta, M Dziubak, L Pietrogrande, L Tagliabue, A Del Sole, T Bini, G Marchetti, A d'Arminio Monforte
OBJECTIVES: The aim of this study was to evaluate the clinical impact of including lateral spine X-ray in the screening of bone diseases in HIV-positive patients. METHODS: A total of 194 HIV-positive patients underwent dual-energy X-ray absorptiometry (DEXA), lateral spine X-ray and bone biochemical analysis. Vertebral fractures were identified using a morphometric analysis of X-rays and classified using the semiquantitative scoring system of Genant et al. For each patient, a spine deformity index (SDI) score was calculated by summing the grades of vertebral deformities...
October 2015: HIV Medicine
https://www.readbyqxmd.com/read/25938463/oldest-pathology-in-a-tetrapod-bone-illuminates-the-origin-of-terrestrial-vertebrates
#20
Peter J Bishop, Christopher W Walmsley, Matthew J Phillips, Michelle R Quayle, Catherine A Boisvert, Colin R McHenry
The origin of terrestrial tetrapods was a key event in vertebrate evolution, yet how and when it occurred remains obscure, due to scarce fossil evidence. Here, we show that the study of palaeopathologies, such as broken and healed bones, can help elucidate poorly understood behavioural transitions such as this. Using high-resolution finite element analysis, we demonstrate that the oldest known broken tetrapod bone, a radius of the primitive stem tetrapod Ossinodus pueri from the mid-Viséan (333 million years ago) of Australia, fractured under a high-force, impact-type loading scenario...
2015: PloS One
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