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Corticosteroid and bronchiolitis

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https://www.readbyqxmd.com/read/28335827/management-of-acute-respiratory-diseases-in-the-pediatric-population-the-role-of-oral-corticosteroids
#1
REVIEW
Renato Cutrera, Eugenio Baraldi, Luciana Indinnimeo, Michele Miraglia Del Giudice, Giorgio Piacentini, Francesco Scaglione, Nicola Ullmann, Laura Moschino, Francesca Galdo, Marzia Duse
Respiratory diseases account for about 25% of all pediatric consultations, and 10% of these are for asthma. The other main pediatric respiratory diseases, in terms of incidence, are bronchiolitis, acute bronchitis and respiratory infections. Oral corticosteroids, in particular prednisolone, are often used to treat acute respiratory diseases given their anti-inflammatory effects. However, the efficacy of treatment with oral corticosteroids differs among the various types of pediatric respiratory diseases. Notably, also the adverse effects of corticosteroid treatment can differ depending on dosage, duration of treatment and type of corticosteroid administered - a case in point being growth retardation in long-course treatment...
March 23, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28144069/a-severe-mycoplasma-pneumoniae-pneumonia-inducing-an-acute-antibody-mediated-pulmonary-graft-rejection
#2
Sarah Démir, Julien Saison, Agathe Sénéchal, Jean-Francois Mornex
A 40-year-old cystic fibrosis woman with a history of double-lung transplantation 2 years previously was admitted for a progressive respiratory distress. Physical examination revealed fever (39°C) and diffuse bilateral lung crackles. Laboratory findings included severe hypoxemia and inflammatory syndrome. Bronchoalveolar lavage and serological test were positive for mycoplasma pneumonia. As the patient did not improve after 3 days of antibiotics and donor-specific HLA antibodies had been detected, an acute antibody-mediated graft rejection was treated with high-dose corticosteroids, plasma exchange, intravenous immunoglobulin, and rituximab...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28138425/successful-treatment-of-pulmonary-injury-after-nitrogen-oxide-exposure-with-corticosteroid-therapy-a-case-report-and-review-of-the-literature
#3
Yasutoshi Kido, Akihisa Mitani, Hideaki Isago, Hideyuki Takeshima, Osamu Narumoto, Goh Tanaka, Yasuhiro Yamauchi, Daiya Takai, Nobuya Ohishi, Takahide Nagase
Nitrogen oxides are representative chemicals of occupational and environmental exposure, which can lead to fatal pulmonary injury. These oxides are also known to cause delayed occurrence of bronchiolitis obliterans (BO). Herein, we report a case of nitrogen oxide-induced lung injury. A 50-year-old man developed pulmonary edema after nitric acid exposure. Hypoxemia and respiratory failure were immediately improved after introduction of corticosteroid pulse therapy with supplemental oxygen. This was followed by administration of oral prednisolone, and delayed BO did not develop...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28117477/hard-metal-lung-disease-a-case-series
#4
Rafael Futoshi Mizutani, Mário Terra-Filho, Evelise Lima, Carolina Salim Gonçalves Freitas, Rodrigo Caruso Chate, Ronaldo Adib Kairalla, Regiani Carvalho-Oliveira, Ubiratan Paula Santos
Objective: To describe diagnostic and treatment aspects of hard metal lung disease (HMLD) and to review the current literature on the topic. Methods: This was a retrospective study based on the medical records of patients treated at the Occupational Respiratory Diseases Clinic of the Instituto do Coração, in the city of São Paulo, Brazil, between 2010 and 2013. Results: Of 320 patients treated during the study period, 5 (1.56%) were diagnosed with HMLD...
November 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27929695/secondhand-smoke-exposure-illness-severity-and-resource-utilization-in-pediatric-emergency-department-patients-with-respiratory-illnesses
#5
Ashley L Merianos, Cinnamon A Dixon, E Melinda Mahabee-Gittens
OBJECTIVE: Hospital-based data reveal that children who have secondhand smoke exposure (SHSe) experience severe respiratory illnesses and greater resource utilization. Our objective was to assess the relationship between SHSe and illness severity/resource utilization among children presenting to the pediatric emergency department (PED) with three common respiratory conditions - asthma, bronchiolitis, and pneumonia. METHODS: A retrospective review of a yearlong consecutive sample of PED patients with SHSe status documentation and asthma, bronchiolitis, or pneumonia diagnoses was performed...
December 8, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27565934/nivolumab-induced-organizing-pneumonitis-in-a-patient-with-lung-sarcomatoid-carcinoma
#6
V Gounant, S Brosseau, C Naltet, M-A Opsomer, M Antoine, C Danel, A Khalil, J Cadranel, G Zalcman
Immune checkpoint inhibitors are known to induce 'immune pneumonitis' in 3-6% of patients treated for lung cancer. However, their dramatic efficacy in as much as 20% of patients led to recent registrations in squamous, and then non-squamous lung carcinoma, in second line setting after failure of first-line chemotherapy, while large phase 3 trials are on-going, to assess first-line immunotherapy, either alone or in combination with chemotherapy. Pulmonary Sarcomatoid carcinomas consist of a rare subset of highly aggressive and poorly differentiated non-small-cell lung carcinomas (NSCLC), with poor prognosis and chemo-resistance...
September 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27549684/viral-bronchiolitis
#7
REVIEW
Todd A Florin, Amy C Plint, Joseph J Zorc
Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract...
January 14, 2017: Lancet
https://www.readbyqxmd.com/read/27498757/post-bronchiolitis-wheezing-is-associated-with-toll-like-receptor-9-rs187084-gene-polymorphism
#8
Kirsi Nuolivirta, Sari Törmänen, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Matti Korppi, Merja Helminen, Ville Peltola, Qiushui He
Innate immunity receptors play a critical role in host defence, as well as in allergy and asthma. The aim of this exploratory study was to evaluate whether there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants were hospitalized for bronchiolitis at age less than 6 months: 129 of them were followed-up until the age of 1.5 years...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27472698/parenchymal-lung-involvement-in-adult-onset-still-disease-a-strobe-compliant-case-series-and-literature-review
#9
REVIEW
Mathieu Gerfaud-Valentin, Vincent Cottin, Yvan Jamilloux, Arnaud Hot, Agathe Gaillard-Coadon, Isabelle Durieu, Christiane Broussolle, Jean Iwaz, Pascal Sève
Parenchymal lung involvement (PLI) in adult-onset Still's disease (AOSD) has seldom, if ever, been studied. We examine here retrospective cohort AOSD cases and present a review of the literature (1971-2014) on AOSD-related PLI cases.Patients with PLI were identified in 57 AOSD cases. For inclusion, the patients had to fulfill Yamaguchi or Fautrel classification criteria, show respiratory symptoms, and have imaging evidence of pulmonary involvement, and data allowing exclusion of infectious, cardiogenic, toxic, or iatrogenic cause of PLI should be available...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27412744/-bronchitis-obliterans-associated-with-bronchiolitis-obliterans-with-organizing-pneumonia-in-a-child-and-literature-review
#10
REVIEW
Q Han, Y Shi, H X Li, W W Tang, H X Liu, D Y Zhao
OBJECTIVE: To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP). METHOD: The clinical manifestations, characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed. RESULT: A 10-year-old girl complained of recurrent paroxysmal cough and episodes of wheezing with exercise, productive of yellowish sputum, irregular fever for 1 month presented with lower breath sounds of left lower lobe and localized tubular breath sounds...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27408784/bronchiolitis-obliterans-organizing-pneumonia-associated-with-achalasia-a-case-report
#11
Farhad Malek, Hossein Nobakhat, Hamidreza Hemmati
There is little mention in the literature about achalasia as an etiologic factor of Bronchiolitis obliterans organizing pneumonia (BOOP). In this study, a case of BOOP, which appeared to be secondary to achalasia is reported. A 35 years old man present with nonproductive cough, chills and fever from two month ago. Due to permanent consolidation in mid zone of right lung and unresponsive to antibiotics, transthoracic needle biopsy was done that showed BOOP. Due to esophageal dilatation in chest computerized tomography (CT) scan, endoscopy and esophagogram was done that showed achalasia...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27383939/impact-of-long-term-treatment-with-inhaled-corticosteroids-and-bronchodilators-on-lung-function-in-a-patient-with-post-infectious-bronchiolitis-obliterans
#12
Cecilia Calabrese, Nadia Corcione, Gaetano Rea, Francesco Stefanelli, Ilernando Meoli, Alessandro Vatrella
Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27303780/acute-viral-bronchiolitis-in-south-africa-strategies-for-management-and-prevention
#13
H J Zar, S A Madhi, D A White, R Masekela, S Risenga, H Lewis, C Feldman, B Morrow, P Jeena
Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27275940/help-desk-answers-do-corticosteroids-reduce-bronchiolitis-hospitalizations
#14
Mohammed R Jendi, Quincy O Scott, Sharon A Smaga
Corticosteroids alone don't decrease hospital admissions or length of stay among children with bronchiolitis. Combining oral dexamethasone and inhaled epinephrine appears to prevent one hospital admission for every 11 patients treated.
May 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27269932/-a-case-of-retroperitoneal-castleman-s-disease-with-paraneoplastic-pemphigus
#15
Zhipeng Zhang, Maosong Zhou, Jin Guo, Tiecheng Feng, Xinying Li, Huan Chen, Jindong Li
Paraneoplastic pemphigus is a rare autoimmune bullous dermatosis, which is caused by potential neoplasm, especially the Castleman's disease. Castleman's disease associated with paraneoplastic pemphigus is misdiagnosed frequently and easily in clinical practices. Furthermore, it is reported that the mortality rate for this disease is very high. Bronchiolitis obliterans is the most common complication and the most important cause of death. There was a female patient presenting recalcitrant mucocutaneous erosions, ulcers and scattered erythemas in the body...
May 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27246587/pulmonary-manifestations-of-sj%C3%A3-gren-s-syndrome
#16
Thomas Flament, Adrien Bigot, Benjamin Chaigne, Helene Henique, Elisabeth Diot, Sylvain Marchand-Adam
In 9-20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy...
June 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27243233/granulomatous-lymphocytic-interstitial-lung-disease-as-the-first-manifestation-of-common-variable-immunodeficiency
#17
Basheer Tashtoush, Roya Memarpour, Jose Ramirez, Pablo Bejarano, Jinesh Mehta
Common variable immunodeficiency (CVID) is one of the most common primary immunodeficiencies, which is characterized by reduced serum immunoglobulin levels and B-lymphocyte dysfunction. There are many clinical manifestations of this disease, the most common of which are recurrent respiratory tract infections. Among the most recently recognized autoimmune manifestation of CVID is a disease described as granulomatous-lymphocytic interstitial lung disease (GLILD), where CVID coexists with a small airway lymphoproliferative disorder, mimicking follicular bronchiolitis, or lymphocytic interstitial pneumonitis (LIP) on histology specimens...
May 31, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27229850/therapeutic-effect-of-budesonide-formoterol-montelukast-and-n-acetylcysteine-for-bronchiolitis-obliterans-syndrome-after-hematopoietic-stem-cell-transplantation
#18
Sei Won Kim, Chin Kook Rhee, Yoo Jin Kim, Seok Lee, Hee Je Kim, Jong Wook Lee
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which are suggested as treatment options for BOS after HSCT. METHODS: After diagnosis of BOS, 61 patients were treated with budesonide/formoterol, montelukast and n-acetylcysteine for 3 months...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27212445/mustard-vesicant-induced-lung-injury-advances-in-therapy
#19
REVIEW
Barry Weinberger, Rama Malaviya, Vasanthi R Sunil, Alessandro Venosa, Diane E Heck, Jeffrey D Laskin, Debra L Laskin
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the pharynx, trachea and bronchioles, while long-term consequences include fibrosis and, in some instances, cancer. Current therapies to treat mustard poisoning are primarily palliative and do not target underlying pathophysiologic mechanisms. New knowledge about vesicant-induced pulmonary disease pathogenesis has led to the identification of potentially efficacious strategies to reduce injury by targeting inflammatory cells and mediators including reactive oxygen and nitrogen species, proteases and proinflammatory/cytotoxic cytokines...
August 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27189595/the-breathing-for-life-trial-a-randomised-controlled-trial-of-fractional-exhaled-nitric-oxide-feno-based-management-of-asthma-during-pregnancy-and-its-impact-on-perinatal-outcomes-and-infant-and-childhood-respiratory-health
#20
Vanessa E Murphy, Megan E Jensen, Joerg Mattes, Michael J Hensley, Warwick B Giles, Michael J Peek, Andrew Bisits, Leonie K Callaway, Kirsten McCaffery, Helen L Barrett, Paul B Colditz, Sean K Seeho, John Attia, Andrew Searles, Christopher Doran, Heather Powell, Peter G Gibson
BACKGROUND: Asthma exacerbations are common during pregnancy and associated with an increased risk of adverse perinatal outcomes. Adjusting asthma treatment based on airway inflammation rather than symptoms reduces the exacerbation rate by 50 %. The Breathing for Life Trial (BLT) will test whether this approach also improves perinatal outcomes. METHODS/DESIGN: BLT is a multicentre, parallel group, randomised controlled trial of asthma management guided by fractional exhaled nitric oxide (FENO, a marker of eosinophilic airway inflammation) compared to usual care, with prospective infant follow-up...
2016: BMC Pregnancy and Childbirth
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