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Corticosteroid and bronchiolitis

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https://www.readbyqxmd.com/read/27565934/nivolumab-induced-organizing-pneumonitis-in-a-patient-with-lung-sarcomatoid-carcinoma
#1
V Gounant, S Brosseau, C Naltet, M-A Opsomer, M Antoine, C Danel, A Khalil, J Cadranel, G Zalcman
Immune checkpoint inhibitors are known to induce 'immune pneumonitis' in 3-6% of patients treated for lung cancer. However, their dramatic efficacy in as much as 20% of patients led to recent registrations in squamous, and then non-squamous lung carcinoma, in second line setting after failure of first-line chemotherapy, while large phase 3 trials are on-going, to assess first-line immunotherapy, either alone or in combination with chemotherapy. Pulmonary Sarcomatoid carcinomas consist of a rare subset of highly aggressive and poorly differentiated non-small-cell lung carcinomas (NSCLC), with poor prognosis and chemo-resistance...
September 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27549684/viral-bronchiolitis
#2
Todd A Florin, Amy C Plint, Joseph J Zorc
Viral bronchiolitis is a common clinical syndrome affecting infants and young children. Concern about its associated morbidity and cost has led to a large body of research that has been summarised in systematic reviews and integrated into clinical practice guidelines in several countries. The evidence and guideline recommendations consistently support a clinical diagnosis with the limited role for diagnostic testing for children presenting with the typical clinical syndrome of viral upper respiratory infection progressing to the lower respiratory tract...
August 20, 2016: Lancet
https://www.readbyqxmd.com/read/27498757/post-bronchiolitis-wheezing-is-associated-with-toll-like-receptor-9-rs187084-gene-polymorphism
#3
Kirsi Nuolivirta, Sari Törmänen, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Matti Korppi, Merja Helminen, Ville Peltola, Qiushui He
Innate immunity receptors play a critical role in host defence, as well as in allergy and asthma. The aim of this exploratory study was to evaluate whether there are associations between TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084 or TLR10 rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants were hospitalized for bronchiolitis at age less than 6 months: 129 of them were followed-up until the age of 1.5 years...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27472698/parenchymal-lung-involvement-in-adult-onset-still-disease-a-strobe-compliant-case-series-and-literature-review
#4
Mathieu Gerfaud-Valentin, Vincent Cottin, Yvan Jamilloux, Arnaud Hot, Agathe Gaillard-Coadon, Isabelle Durieu, Christiane Broussolle, Jean Iwaz, Pascal Sève
Parenchymal lung involvement (PLI) in adult-onset Still's disease (AOSD) has seldom, if ever, been studied. We examine here retrospective cohort AOSD cases and present a review of the literature (1971-2014) on AOSD-related PLI cases.Patients with PLI were identified in 57 AOSD cases. For inclusion, the patients had to fulfill Yamaguchi or Fautrel classification criteria, show respiratory symptoms, and have imaging evidence of pulmonary involvement, and data allowing exclusion of infectious, cardiogenic, toxic, or iatrogenic cause of PLI should be available...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27412744/-bronchitis-obliterans-associated-with-bronchiolitis-obliterans-with-organizing-pneumonia-in-a-child-and-literature-review
#5
Q Han, Y Shi, H X Li, W W Tang, H X Liu, D Y Zhao
OBJECTIVE: To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP). METHOD: The clinical manifestations, characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed. RESULT: A 10-year-old girl complained of recurrent paroxysmal cough and episodes of wheezing with exercise, productive of yellowish sputum, irregular fever for 1 month presented with lower breath sounds of left lower lobe and localized tubular breath sounds...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27408784/bronchiolitis-obliterans-organizing-pneumonia-associated-with-achalasia-a-case-report
#6
Farhad Malek, Hossein Nobakhat, Hamidreza Hemmati
There is little mention in the literature about achalasia as an etiologic factor of Bronchiolitis obliterans organizing pneumonia (BOOP). In this study, a case of BOOP, which appeared to be secondary to achalasia is reported. A 35 years old man present with nonproductive cough, chills and fever from two month ago. Due to permanent consolidation in mid zone of right lung and unresponsive to antibiotics, transthoracic needle biopsy was done that showed BOOP. Due to esophageal dilatation in chest computerized tomography (CT) scan, endoscopy and esophagogram was done that showed achalasia...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27383939/impact-of-long-term-treatment-with-inhaled-corticosteroids-and-bronchodilators-on-lung-function-in-a-patient-with-post-infectious-bronchiolitis-obliterans
#7
Cecilia Calabrese, Nadia Corcione, Gaetano Rea, Francesco Stefanelli, Ilernando Meoli, Alessandro Vatrella
Post-infectious bronchiolitis obliterans (PIBO) is a small airways disease characterized by fixed airflow limitation. Therefore, inhaled bronchodilators and corticosteroids are not recommended as maintenance therapy options. The management of PIBO currently consists only of close monitoring of affected patients, aimed at the prevention and early treatment of pulmonary infections. In recent years, there has been an increase in the incidence of PIBO in the pediatric population. Patients with PIBO are characterized by a progressive decline in lung function, accompanied by a decrease in overall functional capacity...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27303780/acute-viral-bronchiolitis-in-south-africa-strategies-for-management-and-prevention
#8
H J Zar, S A Madhi, D A White, R Masekela, S Risenga, H Lewis, C Feldman, B Morrow, P Jeena
Management of acute viral bronchiolitis is largely supportive. There is currently no proven effective therapy other than oxygen for hypoxic children. The evidence indicates that there is no routine benefit from inhaled, rapid short-acting bronchodilators, adrenaline or ipratropium bromide for children with acute viral bronchiolitis. Likewise, there is no demonstrated benefit from routine use of inhaled or oral corticosteroids, inhaled hypertonic saline nebulisation, montelukast or antibiotics. The last should be reserved for children with severe disease, when bacterial co-infection is suspected...
April 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27275940/help-desk-answers-do-corticosteroids-reduce-bronchiolitis-hospitalizations
#9
Mohammed R Jendi, Quincy O Scott, Sharon A Smaga
Corticosteroids alone don't decrease hospital admissions or length of stay among children with bronchiolitis. Combining oral dexamethasone and inhaled epinephrine appears to prevent one hospital admission for every 11 patients treated.
May 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27269932/-a-case-of-retroperitoneal-castleman-s-disease-with-paraneoplastic-pemphigus
#10
Zhipeng Zhang, Maosong Zhou, Jin Guo, Tiecheng Feng, Xinying Li, Huan Chen, Jindong Li
Paraneoplastic pemphigus is a rare autoimmune bullous dermatosis, which is caused by potential neoplasm, especially the Castleman's disease. Castleman's disease associated with paraneoplastic pemphigus is misdiagnosed frequently and easily in clinical practices. Furthermore, it is reported that the mortality rate for this disease is very high. Bronchiolitis obliterans is the most common complication and the most important cause of death. There was a female patient presenting recalcitrant mucocutaneous erosions, ulcers and scattered erythemas in the body...
May 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27246587/pulmonary-manifestations-of-sj%C3%A3-gren-s-syndrome
#11
Thomas Flament, Adrien Bigot, Benjamin Chaigne, Helene Henique, Elisabeth Diot, Sylvain Marchand-Adam
In 9-20% of cases, Sjögren's syndrome is associated with various respiratory symptoms. The most typical manifestations are chronic interstitial lung disease (ILD) and tracheobronchial disease. The most common manifestation of ILD is nonspecific interstitial pneumonia in its fibrosing variant. Other types of ILD, such as organising pneumonia, usual interstitial pneumonia and lymphocytic interstitial pneumonitis, are rare. Their radiological presentation is less distinctive, and definitive diagnosis may require the use of transbronchial or surgical lung biopsy...
June 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27243233/granulomatous-lymphocytic-interstitial-lung-disease-as-the-first-manifestation-of-common-variable-immunodeficiency
#12
Basheer Tashtoush, Roya Memarpour, Jose Ramirez, Pablo Bejarano, Jinesh Mehta
Common variable immunodeficiency (CVID) is one of the most common primary immunodeficiencies, which is characterized by reduced serum immunoglobulin levels and B-lymphocyte dysfunction. There are many clinical manifestations of this disease, the most common of which are recurrent respiratory tract infections. Among the most recently recognized autoimmune manifestation of CVID is a disease described as granulomatous-lymphocytic interstitial lung disease (GLILD), where CVID coexists with a small airway lymphoproliferative disorder, mimicking follicular bronchiolitis, or lymphocytic interstitial pneumonitis (LIP) on histology specimens...
May 31, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27229850/therapeutic-effect-of-budesonide-formoterol-montelukast-and-n-acetylcysteine-for-bronchiolitis-obliterans-syndrome-after-hematopoietic-stem-cell-transplantation
#13
Sei Won Kim, Chin Kook Rhee, Yoo Jin Kim, Seok Lee, Hee Je Kim, Jong Wook Lee
BACKGROUND: Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which are suggested as treatment options for BOS after HSCT. METHODS: After diagnosis of BOS, 61 patients were treated with budesonide/formoterol, montelukast and n-acetylcysteine for 3 months...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27212445/mustard-vesicant-induced-lung-injury-advances-in-therapy
#14
REVIEW
Barry Weinberger, Rama Malaviya, Vasanthi R Sunil, Alessandro Venosa, Diane E Heck, Jeffrey D Laskin, Debra L Laskin
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the pharynx, trachea and bronchioles, while long-term consequences include fibrosis and, in some instances, cancer. Current therapies to treat mustard poisoning are primarily palliative and do not target underlying pathophysiologic mechanisms. New knowledge about vesicant-induced pulmonary disease pathogenesis has led to the identification of potentially efficacious strategies to reduce injury by targeting inflammatory cells and mediators including reactive oxygen and nitrogen species, proteases and proinflammatory/cytotoxic cytokines...
August 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27189595/the-breathing-for-life-trial-a-randomised-controlled-trial-of-fractional-exhaled-nitric-oxide-feno-based-management-of-asthma-during-pregnancy-and-its-impact-on-perinatal-outcomes-and-infant-and-childhood-respiratory-health
#15
Vanessa E Murphy, Megan E Jensen, Joerg Mattes, Michael J Hensley, Warwick B Giles, Michael J Peek, Andrew Bisits, Leonie K Callaway, Kirsten McCaffery, Helen L Barrett, Paul B Colditz, Sean K Seeho, John Attia, Andrew Searles, Christopher Doran, Heather Powell, Peter G Gibson
BACKGROUND: Asthma exacerbations are common during pregnancy and associated with an increased risk of adverse perinatal outcomes. Adjusting asthma treatment based on airway inflammation rather than symptoms reduces the exacerbation rate by 50 %. The Breathing for Life Trial (BLT) will test whether this approach also improves perinatal outcomes. METHODS/DESIGN: BLT is a multicentre, parallel group, randomised controlled trial of asthma management guided by fractional exhaled nitric oxide (FENO, a marker of eosinophilic airway inflammation) compared to usual care, with prospective infant follow-up...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27177013/a-regional-cohort-study-of-the-treatment-of-critically-ill-children-with-bronchiolitis
#16
Christopher L Carroll, Edward Vincent S Faustino, Matthew G Pinto, Kathleen A Sala, Michael F Canarie, Simon Li, John S Giuliano, The Northeast Pediatric Critical Care Research Consortium
OBJECTIVE: To describe the treatment practices in critically ill children with RSV bronchiolitis across four regional PICUs in the northeastern United States, and to determine the factors associated with increased ICU length of stay in this population. METHODS: We conducted a retrospective cohort study of children who were admitted with RSV bronchiolitis between July 2009 and July 2011 to the PICUs of Connecticut Children's Medical Center, Yale-New Haven Children's Hospital, Maria Fareri Children's Hospital, and Baystate Children's Hospital...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27097575/-efficacy-of-fluticasone-propionate-aerosol-versus-budesonide-suspension-in-treatment-of-recurrent-wheezing-caused-by-bronchiolitis
#17
RANDOMIZED CONTROLLED TRIAL
Wei-Ping Lan, Jing Wang, Chuan-Lin Dai, Jia-Hua Pan
OBJECTIVE: To investigate the efficacy of fluticasone propionate aerosol (flixotide) versus budesonide suspension in the treatment of recurrent wheezing caused by bronchiolitis. METHODS: A total of 214 infants with newly diagnosed bronchiolitis were randomly divided into flixotide treatment (106 infants) and budesonide treatment groups (108 infants), and were given aerosol inhalation of flixotide or budesonide for 3 months after achieving remission of clinical symptoms...
April 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/26906352/management-of-bronchiolitis-in-community-hospitals-in-ontario-a-multicentre-cohort-study
#18
Amy C Plint, Monica Taljaard, Candice McGahern, Shannon D Scott, Jeremy M Grimshaw, Terry P Klassen, David W Johnson
OBJECTIVES: Bronchiolitis is the leading cause of hospital admission for infants, but few studies have examined management of this condition in community hospital settings. We reviewed the management of children with bronchiolitis presenting to community hospitals in Ontario. METHODS: We retrospectively reviewed a consecutive cohort of infants less than 12 months old with bronchiolitis who presented to 28 Ontario community hospitals over a two-year period. Bronchiolitis was defined as first episode of wheezing associated with signs of an upper respiratory tract infection during respiratory syncytial virus season...
February 24, 2016: CJEM
https://www.readbyqxmd.com/read/26875009/children-hospitalized-with-rhinovirus-bronchiolitis-have-asthma-like%C3%A2-characteristics
#19
Jonathan M Mansbach, Sunday Clark, Stephen J Teach, James E Gern, Pedro A Piedra, Ashley F Sullivan, Janice A Espinola, Carlos A Camargo
Children with bronchiolitis often are considered a homogeneous group. However, in a multicenter, prospective study of 2207 young children hospitalized for bronchiolitis, we found that children with respiratory syncytial virus detected differ from those with rhinovirus detected; the latter patients resemble older children with asthma, including more frequent treatment with corticosteroids.
May 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26790556/unusual-pulmonary-toxicity-of-ipilimumab-treated-by-macrolides
#20
M Mailleux, F Cornélis, G C Colin, J-F Baurain
INTRODUCTION: Ipilimumab is a human monoclonal antibody that blocks cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) and promotes antitumour immunity. It has recently been approved for the treatment of metastatic melanoma patients. Ipilimumab is now widely used and the spectrum of side effects because of autoimmunity is expanding. To our knowledge, this is the first report of an ipilimumab-induced pulmonary immune-related adverse event (irAE) that was successfully treated by macrolides without corticosteroids...
December 2015: Acta Clinica Belgica
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