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JOURNAL ARTICLE
Rachel Passarelli, John Pfail, Alain Kaldany, Kevin Chua, Benjamin Lichtbroun, Hiren V Patel, Arnav Srivastava, David Golombos, Thomas L Jang, Vignesh T Packiam, Saum Ghodoussipour
OBJECTIVES: To identify the impact of the duration of peri-operative antibiotics on infectious complications following radical cystectomy. METHODS: The National Surgical Quality Improvement Project (NSQIP) targeted database was queried for patients undergoing radical cystectomy from 2019-2021. Baseline patient characteristics were collected. Antibiotic duration was classified as <24 hours (short), 24-72 hours (intermediate) or >72 hours (long). Infectious complication data was collected including surgical site infection (SSI), urinary tract infection (UTI), organ space infection, pneumonia, sepsis, and clostridium difficile infection up to 30 days after surgery...
April 20, 2024: Urology
#2
JOURNAL ARTICLE
Larissa Fabritz, Winnie Chua, Victor R Cardoso, Christoph Al-Taie, Katrin Borof, Anna Suling, Linda Krause, Shino Kany, Christina Magnussen, Karl Wegscheider, Guenter Breithardt, Harry J G M Crijns, A John Camm, George Gkoutos, Patrick T Ellinor, Andreas Goette, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Renate B Schnabel, Antonia Zapf, Paulus Kirchhof
BACKGROUND: Atrial fibrillation (AF) and concomitant cardiometabolic disease processes interact and combine to lead to adverse events such as stroke, heart failure, myocardial infarction, and cardiovascular death. Circulating biomolecules provide quantifiable proxies for cardiometabolic disease processes. Their role in defining subphenotypes of AF is not known. METHODS AND RESULTS: This prespecified analysis of the EAST-AFNET4 biomolecule study assigned patients to clusters using polytomous variable latent class analysis (poLCA) based on baseline concentrations of thirteen precisely-quantified biomolecules potentially reflecting ageing, cardiac fibrosis, metabolic dysfunction, oxidative stress, cardiac load, endothelial dysfunction, and inflammation...
April 13, 2024: Cardiovascular Research
#3
JOURNAL ARTICLE
Chua Zu'Er Amelia, Chan Hiu Gwan, Tan Shu Qi, John Tee Chee Seng
Vitamin D plays an essential role in bone and mineral metabolism. There is increased interest in understanding prevalence of Vitamin D deficiency in pregnancy as many studies report association of low vitamin D levels with obstetric complications and neonatal sequelae. There is a paucity of studies in Singapore evaluating levels of vitamin D levels during the first trimester of pregnancies. We aim to study the prevalence of vitamin D insufficiency in this population. Our study assessed vitamin D levels in these women...
2024: PloS One
#4
JOURNAL ARTICLE
Sujith Baliga, Ahmad K Abou-Foul, Pablo Parente, Petr Szturz, Juliette Thariat, Aditya Shreenivas, Paul Nankivell, Federica Bertolini, Julian Biau, Dukagjin Blakaj, Sinead Brennan, Aina Brunet, Thiago Bueno De Oliveira, Barbara Burtness, Alberto Carral Maseda, Velda Ling-Yu Chow, Melvin Lk Chua, Mischa de Ridder, Satya Garikipati, Nobuhiro Hanai, Francis Cho Hao Ho, Shao Hui Huang, Naomi Kiyota, Konrad Klinghammer, Luiz P Kowalski, Dora L Kwong, Lachlan J McDowell, Marco Carlo Merlano, Sudhir Nair, Panagiota Economopoulou, Jens Overgaard, Amanda Psyrri, Silke Tribius, John Waldron, Sue S Yom, Hisham Mehanna
The Head and Neck Cancer International Group (HNCIG) has undertaken an international modified Delphi process to reach consensus on the essential data variables to be included in a minimum database for HNC research. Endorsed by 19 research organisations representing 34 countries, these recommendations provide the framework to facilitate and harmonise data collection and sharing for HNC research. These variables have also been incorporated into a ready to use downloadable HNCIG minimum database, available from the HNCIG website...
March 30, 2024: European Journal of Cancer
#5
JOURNAL ARTICLE
Ing Soo Tiong, Meaghan Wall, Ashish Bajel, Akash Kalro, Shaun Fleming, Andrew W Roberts, Nisha Thiagarajah, Chong Chyn Chua, Maya Latimer, David Yeung, Paula Marlton, Amanda Johnston, Anoop Enjeti, Chun Yew Fong, Gavin Cull, Stephen Larsen, Glen Kennedy, Anthony Schwarer, David Kipp, Sundra Ramanathan, Emma Verner, Campbell Tiley, Edward Morris, Uwe Hahn, John Moore, John Taper, Duncan Purtill, Pauline Warburton, William Stevenson, Nicholas Murphy, Peter Tan, Ashanka Beligaswatte, Howard Mutsando, Mark Hertzberg, Jake Shortt, Ferenc Szabo, Karin Dunne, Andrew H Wei
Despite an increasing desire to use historical cohorts as "synthetic" controls for new drug evaluation, limited data exist regarding the comparability of real-world outcomes to those in clinical trials. Governmental cancer data often lacks details on treatment, response, and molecular characterization of disease sub-groups. The Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry (ALLG NBCR) includes source information on morphology, cytogenetics, flow cytometry, and molecular features linked to treatment received (including transplantation), response to treatment, relapse, and survival outcome...
March 26, 2024: Blood Cancer Journal
#6
JOURNAL ARTICLE
Isabelle Jia-Hui Foo, Brendon Y Chua, E Bridie Clemens, So Young Chang, Xiaoxiao Jia, Hayley A McQuilten, Ashley Huey Yiing Yap, Aira F Cabug, Mitra Ashayeripanah, Hamish E G McWilliam, Jose A Villadangos, Maximilien Evrard, Laura K Mackay, Linda M Wakim, John K Fazakerley, Katherine Kedzierska, Lukasz Kedzierski
Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are highly relevant to treatment and prevention. We established a mouse model of co-infection with unrelated viruses, influenza A (IAV) and Semliki Forest virus (SFV), causing disease in different organ systems. SFV infection eight days before IAV infection results in prolonged IAV replication, elevated cytokine/chemokine levels and exacerbated lung pathology...
March 23, 2024: Nature Communications
#7
JOURNAL ARTICLE
Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Ru-San Tan, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, Xiaodan Zhao, John Allen, Qinghua Wu, Tim Leiner, Liang Zhong, Angela S Koh
Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus...
March 22, 2024: GeroScience
#8
Zhen Ling Teo, Liyuan Jin, Nan Liu, Siqi Li, Di Miao, Xiaoman Zhang, Wei Yan Ng, Ting Fang Tan, Deborah Meixuan Lee, Kai Jie Chua, John Heng, Yong Liu, Rick Siow Mong Goh, Daniel Shu Wei Ting
No abstract text is available yet for this article.
March 19, 2024: Cell reports medicine
#9
JOURNAL ARTICLE
Hongzhou Zhang, Shuang Leng, Fei Gao, Jean-Paul Kovalik, Hai Ning Wee, Kee Voon Chua, Jianhong Ching, John C Allen, Xiaodan Zhao, Ru-San Tan, Qinghua Wu, Tim Leiner, Angela S Koh, Liang Zhong
BACKGROUND: Pulmonary artery (PA) strain is associated with structural and functional alterations of the vessel and is an independent predictor of cardiovascular events. The relationship of PA strain to metabolomics in participants without cardiovascular disease is unknown. METHODS: In the current study, community-based older adults, without known cardiovascular disease, underwent simultaneous cine cardiovascular magnetic resonance (CMR) imaging, clinical examination, and serum sampling...
2024: Frontiers in Cardiovascular Medicine
#10
JOURNAL ARTICLE
Catherine Kubrak, Lisa Martin, Aaron J Grossberg, Brennan Olson, Faith Ottery, Merran Findlay, Judith D Bauer, Naresh Jha, Rufus Scrimger, Brock Debenham, Neil Chua, John Walker, Vickie Baracos
BACKGROUND & AIMS: Existing skeletal muscle index (SMI) thresholds for sarcopenia are inconsistent, and do not reflect severity of depletion. In this study we aimed to define criterion values for moderate and severe skeletal muscle depletion based on the risk of mortality in a population of patients with head and neck cancer (HNC). Additionally, we aimed to identify clinical and demographic predictors of skeletal muscle depletion, evaluate the survival impact of skeletal muscle depletion in patients with minimal nutritional risk or good performance status, and finally, benchmarking SMI values of patients with HNC against healthy young adults...
April 2024: Clinical Nutrition
#11
JOURNAL ARTICLE
Rohan Jha, David D Liu, Jakob V E Gerstl, Sophia Renauld, John L Kilgallon, Sarah E Blitz, Lila Medeiros, Noah L A Nawabi, Hargunbir Singh, Melissa M J Chua, Steven Tobochnik, G Rees Cosgrove, John D Rolston
OBJECTIVE: Surgical intervention can be curative or palliative for drug-resistant focal epilepsy. However, if the seizure onset zone (SOZ) cannot be adequately localized via noninvasive tests, intracranial EEG (iEEG) recordings are often carried out to develop surgical plans in appropriate candidates. Stereotactic EEG (SEEG), subdural EEG (SDE), and SDE with depth electrodes (hybrid) are major tools used for investigation, but there is no class 1 or 2 evidence comparing the effectiveness of these modalities...
March 8, 2024: Journal of Neurosurgery
#12
REVIEW
Rohan Jha, Sarah E Blitz, Melissa M J Chua, Aaron E L Warren, Jong Woo Lee, John D Rolston
Status Epilepticus (SE), unresponsive to medical management, is associated with high morbidity and mortality. Surgical management is typically considered in these refractory cases. The best surgical approach for affected patients remains unclear; however, given the lack of controlled trials exploring the role of surgery. We performed a systematic review according to PRIMSA guidelines, including case reports and series describing surgical interventions for patients in SE. Cases (157 patients, median age 12.9 years) were followed for a median of 12 months...
March 8, 2024: Epilepsia Open
#13
JOURNAL ARTICLE
Alon Ascoli, Nicolas Schmitt, Ioannis Messaris, Ahmet Samil Demirkol, John Paul Strachan, Ronald Tetzlaff, Leon Chua
A nonlinear system, exhibiting a unique asymptotic behaviour, while being continuously subject to a stimulus from a certain class, is said to suffer from fading memory. This interesting phenomenon was first uncovered in a non-volatile tantalum oxide-based memristor from Hewlett Packard Labs back in 2016 out of a deep numerical investigation of a predictive mathematical description, known as the Strachan model, later corroborated by experimental validation. It was then found out that fading memory is ubiquitous in non-volatile resistance switching memories...
March 7, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Ing Soo Tiong, Devendra K Hiwase, Emad Abro, Ashish Bajel, Emma Palfreyman, Ashanka Beligaswatte, John Reynolds, Natasha Anstee, Tamia Nguyen, Sun Loo, Chong Chyn Chua, Michael Ashby, Kaitlyn M Wiltshire, Shaun Fleming, Chun Y Fong, Tse-Chieh Teh, Piers Blombery, Richard Dillon, Adam Ivey, Andrew H Wei
PURPOSE: A prospective phase II study examined the safety and efficacy of venetoclax combined with low-dose cytarabine (LDAC) in AML at first measurable residual disease (MRD) or oligoblastic relapse. METHODS: Patients with either MRD (≥1 log10 rise) or oligoblastic relapse (blasts 5%-15%) received venetoclax 600 mg once daily D1-28 plus LDAC once daily D1-10 in 28-day cycles. The primary objective was MRD response in the MRD relapse cohort or complete remission (CR/CRh/CRi) in the oligoblastic relapse cohort...
March 1, 2024: Journal of Clinical Oncology
#15
REVIEW
John Chee Meng Wong, Joelle Yan Xin Chua, Pao Yi Chan, Shefaly Shorey
AIM: To examine the effectiveness of educational interventions in reducing stigma among healthcare professionals and students towards people with mental illness. DESIGN: A systematic review and meta-analysis of randomized controlled trials (RCTs) and cluster RCTs. DATA SOURCES: Articles published from database inception to October 2023 were systematically searched from seven databases (CINAHL, Embase, ProQuest Dissertations and Theses Global, PsycINFO, PubMed, Scopus, Web of Science), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
February 25, 2024: Journal of Advanced Nursing
#16
JOURNAL ARTICLE
Zhen Ling Teo, Liyuan Jin, Siqi Li, Di Miao, Xiaoman Zhang, Wei Yan Ng, Ting Fang Tan, Deborah Meixuan Lee, Kai Jie Chua, John Heng, Yong Liu, Rick Siow Mong Goh, Daniel Shu Wei Ting
Federated learning (FL) is a distributed machine learning framework that is gaining traction in view of increasing health data privacy protection needs. By conducting a systematic review of FL applications in healthcare, we identify relevant articles in scientific, engineering, and medical journals in English up to August 31st, 2023. Out of a total of 22,693 articles under review, 612 articles are included in the final analysis. The majority of articles are proof-of-concepts studies, and only 5.2% are studies with real-life application of FL...
February 2, 2024: Cell reports medicine
#17
JOURNAL ARTICLE
Nicole Yu, Mazhar Pasha, John Jia En Chua
The redox process and cellular senescence are involved in a range of essential physiological functions. However, they are also implicated in pathological processes underlying age-related neurodegenerative disorders, including Alzheimer's disease (AD). Elevated levels of reactive oxygen species (ROS) are generated as a result of abnormal accumulation of beta-amyloid peptide (Aβ), tau protein, and heme dyshomeostasis and is further aggravated by mitochondria dysfunction and endoplasmic reticulum (ER) stress...
January 17, 2024: Redox Biology
#18
JOURNAL ARTICLE
Giles Dixon, Samuel Hague, Sarah Mulholland, Huzaifa Adamali, Aye Myat Noe Khin, Hannah Thould, Roisin Connon, Paul Minnis, Eoin Murtagh, Fasihul Khan, Sameen Toor, Alexandra Lawrence, Marium Naqvi, Alex West, Robina K Coker, Katie Ward, Leda Yazbeck, Simon Hart, Theresa Garfoot, Kate Newman, Pilar Rivera-Ortega, Lachlan Stranks, Paul Beirne, Jessica Bradley, Catherine Rowan, Sarah Agnew, Mahin Ahmad, Lisa G Spencer, Joshua Aigbirior, Ahmed Fahim, Andrew M Wilson, Elizabeth Butcher, Sy Giin Chong, Gauri Saini, Sabrina Zulfikar, Felix Chua, Peter M George, Maria Kokosi, Vasileios Kouranos, Philip Molyneaux, Elisabetta Renzoni, Benedetta Vitri, Athol U Wells, Lisa M Nicol, Stephen Bianchi, Raman Kular, HuaJian Liu, Alexander John, Sarah Barth, Melissa Wickremasinghe, Ian A Forrest, Ian Grimes, A John Simpson, Sophie V Fletcher, Mark G Jones, Emma Kinsella, Jennifer Naftel, Nicola Wood, Jodie Chalmers, Anjali Crawshaw, Louise E Crowley, Davinder Dosanjh, Christopher C Huntley, Gareth I Walters, Timothy Gatheral, Catherine Plum, Shiva Bikmalla, Raja Muthusami, Helen Stone, Jonathan C L Rodrigues, Krasimira Tsaneva-Atanasova, Chris J Scotton, Michael A Gibbons, Shaney L Barratt
BACKGROUND: Nintedanib slows progression of lung function decline in patients with progressive fibrosing (PF) interstitial lung disease (ILD) and was recommended for this indication within the United Kingdom (UK) National Health Service in Scotland in June 2021 and in England, Wales and Northern Ireland in November 2021. To date, there has been no national evaluation of the use of nintedanib for PF-ILD in a real-world setting. METHODS: 26 UK centres were invited to take part in a national service evaluation between 17 November 2021 and 30 September 2022...
January 2024: ERJ Open Research
#19
JOURNAL ARTICLE
Christina Menexi, Mohamed ElRefai, Mohamed Abouelasaad, Anne Y T Chua, Ishita Handa, Clare Newbery, Nicola Hoskins, Waqas Ullah, Arthur Yue, Paul R Roberts, John Paisey
BACKGROUND: Peri-procedural complications associated with cardiac implantable electronic devices are not uncommon. European Society of Cardiology guidelines recommend device checks of all devices within 72 h of implant. European Heart Rhythm Association expert practical guide on Cardiac implantable electronic devices (CIEDs) recommend that a chest x-ray (CXR) should be performed within 24 h to rule out pneumothorax and document lead positions. First, the rate of peri-procedural complications associated with CIED implants at our center, as well as patient and/or procedural-related factors that are associated with higher rates of complications, is analyzed...
February 2024: Pacing and Clinical Electrophysiology: PACE
#20
JOURNAL ARTICLE
Yinghua Qu, Jonathan Jun-Yong Lim, Omer An, Henry Yang, Yi-Chin Toh, John Jia En Chua
Mutations in the human fasciculation and elongation protein zeta 1 ( FEZ1) gene are found in schizophrenia and Jacobsen syndrome patients. Here, using human cerebral organoids (hCOs), we show that FEZ1 expression is turned on early during brain development and is detectable in both neuroprogenitor subtypes and immature neurons. FEZ1 deletion disrupts expression of neuronal and synaptic development genes. Using single-cell RNA sequencing, we detected abnormal expansion of homeodomain-only protein homeobox (HOPX)- outer radial glia (oRG), concurrent with a reduction of HOPX+ oRG, in FEZ1-null hCOs...
December 15, 2023: IScience
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