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John Chua

Narayanaswamy Venketasubramanian, Chun Fan Lee, Sherry H Young, San San Tay, Thirugnanam Umapathi, Annabelle Y Lao, Herminigildo H Gan, Alejandro C Baroque Ii, Jose C Navarro, Hui Meng Chang, Joel M Advincula, Sombat Muengtaweepongsa, Bernard P L Chan, Carlos L Chua, Nirmala Wijekoon, H Asita de Silva, John Harold B Hiyadan, Nijasri C Suwanwela, K S Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Christopher L H Chen
BACKGROUND: The Chinese Medicine NeuroAiD Efficacy on Stroke recovery - Extension (CHIMES-E) study is among the few acute stroke trials with long-term outcome data. We aimed to evaluate the recovery pattern and the influence of prognostic factors on treatment effect of MLC601 over 2 years. METHODS: The CHIMES-E study evaluated the 2 years outcome of subjects aged ≥18 years with acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) score 6-14, pre-stroke modified Rankin Scale (mRS) score ≤1 included in a multicenter, randomized, double-blind, placebo-controlled trial of MLC601 for 3 months...
November 15, 2016: Cerebrovascular Diseases
Jose C Navarro, Christopher Lh Chen, Chun F Lee, Herminigildo H Gan, Annabelle Y Lao, Alejandro C Baroque, John Harold B Hiyadan, Carlos L Chua, Ma Cristina San Jose, Joel M Advincula, Narayanaswamy Venketasubramanian
BACKGROUND AND AIM: A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort. METHODS: The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years...
October 26, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
Jingyi Zhu, Tilo Mathes, Yusaku Hontani, Maxime T A Alexandre, Kee Chua Toh, Peter Hegemann, John T M Kennis
The two Light, Oxygen, and Voltage domains of phototropin are blue-light photoreceptor domains which control various functions in plants and green algae. The key step of the light-driven reaction is the formation of a photoadduct between its FMN chromophore and a conserved cysteine, where the canonical reaction proceeds through the FMN triplet state. Here, complete photoreaction mapping of CrLOV2 from Chlamydomonas reinhardtii phototropin and AsLOV2 from Avena sativa phototropin-1 was realized by ultrafast broadband spectroscopy from femtoseconds to microseconds...
October 21, 2016: Journal of Physical Chemistry Letters
Edith Pituskin, Mark Haykowsky, Margaret McNeely, John Mackey, Neil Chua, Ian Paterson
BACKGROUND: Cancer is the leading cause of premature death in Canada. In the last decade, important gains in cancer survival have been achieved by advances in adjuvant treatment. However, many oncologic treatments also result in cardiovascular "toxicity". Furthermore, cardiac risk factors such as hypertension, dyslipidemia, and diabetes mellitus are known to contribute to the progression of cardiac damage and clinical cardiotoxicity. As such, for many survivors, the risk of death from cardiac disease exceeds that of recurrent cancer...
September 15, 2016: BMC Cancer
Sabine Dittrich, Birkneh Tilahun Tadesse, Francis Moussy, Arlene Chua, Anna Zorzet, Thomas Tängdén, David L Dolinger, Anne-Laure Page, John A Crump, Valerie D'Acremont, Quique Bassat, Yoel Lubell, Paul N Newton, Norbert Heinrich, Timothy J Rodwell, Iveth J González
Acute fever is one of the most common presenting symptoms globally. In order to reduce the empiric use of antimicrobial drugs and improve outcomes, it is essential to improve diagnostic capabilities. In the absence of microbiology facilities in low-income settings, an assay to distinguish bacterial from non-bacterial causes would be a critical first step. To ensure that patient and market needs are met, the requirements of such a test should be specified in a target product profile (TPP). To identify minimal/optimal characteristics for a bacterial vs...
2016: PloS One
Moones Heidari, Sam H Gerami, Brianna Bassett, Ross M Graham, Anita C G Chua, Ritambhara Aryal, Michael J House, Joanna F Collingwood, Conceição Bettencourt, Henry Houlden, Mina Ryten, John K Olynyk, Debbie Trinder, Daniel M Johnstone, Elizabeth A Milward
We previously demonstrated elevated brain iron levels in myelinated structures and associated cells in a hemochromatosis Hfe (-/-) xTfr2 (mut) mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family 'neurodegeneration with brain iron accumulation' (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading...
2016: Rare Diseases
Anita Cg Chua, Matthew W Knuiman, Debbie Trinder, Mark L Divitini, John K Olynyk
BACKGROUND: Although the carcinogenic potential of iron has been shown, evidence from observational studies that have linked serum iron variables and cancer outcomes has been inconsistent. OBJECTIVE: We investigated whether higher iron concentrations increased risk of cancer outcomes. DESIGN: A prospective examination of iron biomarkers as independent risk factors for cancer was assessed in 1597 men and 1795 women aged 25-79 y who participated in the 1994/1995 Busselton Health Survey and had relevant data, no history of cancer before the survey, and serum ferritin concentrations ≥20 μg/L...
September 2016: American Journal of Clinical Nutrition
Ming Xu, Vivien P Chua
Intensive economic and shipping activities in Singapore Strait have caused Singapore coastal waters to be under high risk of water pollution. A nested three-dimensional unstructured-grid SUNTANS model is applied to Singapore coastal waters to simulate flow and pollutant transport. The small domain (~50m resolution) Singapore coastal model is nested within a large domain (~200m resolution) regional model. The nested model is able to predict water surface elevations and velocities with high R(2) values of 0.96 and 0...
October 15, 2016: Marine Pollution Bulletin
Julie Brown, John Kam Hung Sinn, Aileen Chua, Elizabeth Clare Clarke
INTRODUCTION: Child restraint fit is important for crash protection. For newborns, standards universally require a rear-facing restraint and some upper limit on size, but historically there has been no specification of a lower design limit and there is concern over whether low birthweight infants (LBW) are adequately restrained. The aim of this study was to determine the quality of harness fit for newborns of low and normal weight in a range of modern child restraints. METHODS: A convenience sample of infants (1...
July 15, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Laurie H Sehn, Neil Chua, Jiri Mayer, Gregg Dueck, Marek Trněný, Kamal Bouabdallah, Nathan Fowler, Vincent Delwail, Oliver Press, Gilles Salles, John Gribben, Anne Lennard, Pieternella J Lugtenburg, Natalie Dimier, Elisabeth Wassner-Fritsch, Günter Fingerle-Rowson, Bruce D Cheson
BACKGROUND: Patients with indolent non-Hodgkin lymphoma who fail to achieve adequate disease control with rituximab-based treatment have few treatment options and a poor prognosis. We aimed to assess a combination of obinutuzumab (GA101), a novel glyco-engineered type II anti-CD20 monoclonal antibody, and bendamustine in this patient population. METHODS: In this open-label, randomised, phase 3 study (GADOLIN), patients aged 18 years or older with histologically documented, CD20-positive indolent non-Hodgkin lymphoma refractory to rituximab were enrolled at 83 hospital and community sites in 14 countries in Europe, Asia, and North and Central America...
August 2016: Lancet Oncology
Eugenia Butkevich, Wolfgang Härtig, Miroslav Nikolov, Christian Erck, Jens Grosche, Henning Urlaub, Christoph F Schmidt, Dieter R Klopfenstein, John Jia En Chua
Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 adapter FEZ1 are enriched for presynaptic components and identify that specific phosphorylation of FEZ1 at its serine 58 regulatory site is mediated by microtubule affinity-regulating kinases (MARK/PAR-1)...
2016: Scientific Reports
Tze-Ern Chua, John Carson Allen, Loretta Ang, Li Lian Ong, Ying Chia Ch'ng, Helen Chen
INTRODUCTION: Antenatal major depression is a relatively common and potentially debilitating illness, but unfortunately, knowledge about treatment outcomes and strategies is lacking. This study aimed to explore the clinical profiles and treatment outcomes of patients with antenatal depression for patterns and associations that could guide subsequent research and clinical applications. METHODS: From May 2006 to November 2010, 118 consecutive patients with antenatal depression were naturalistically assessed over eight months of individualised therapy and participant characteristics were assessed as potential predictors of treatment outcome...
June 1, 2016: Singapore Medical Journal
Otilia Nuta, Navita Somaiah, Sue Boyle, Melvin Lee Kiang Chua, Lone Gothard, John Yarnold, Kai Rothkamm, Carsten Herskind
No abstract text is available yet for this article.
May 12, 2016: Cancer Letters
Jun-Mei Zhang, Liang Zhong, Tong Luo, Aileen Mae Lomarda, Yunlong Huo, Jonathan Yap, Soo Teik Lim, Ru San Tan, Aaron Sung Lung Wong, Jack Wei Chieh Tan, Khung Keong Yeo, Jiang Ming Fam, Felix Yung Jih Keng, Min Wan, Boyang Su, Xiaodan Zhao, John Carson Allen, Ghassan S Kassab, Terrance Siang Jin Chua, Swee Yaw Tan
Invasive fractional flow reserve (FFR) is the gold standard to assess the functional coronary stenosis. The non-invasive assessment of diameter stenosis (DS) using coronary computed tomography angiography (CTA) has high false positive rate in contrast to FFR. Combining CTA with computational fluid dynamics (CFD), recent studies have shown promising predictions of FFRCT for superior assessment of lesion severity over CTA alone. The CFD models tend to be computationally expensive, however, and require several hours for completing analysis...
2016: PloS One
Mahdokht Kohansal-Nodehi, John Je Chua, Henning Urlaub, Reinhard Jahn, Dominika Czernik
Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of the membrane of synaptic vesicles. While many of the proteins governing these processes are known, their regulation is only beginning to be understood. Here we have applied quantitative phosphoproteomics to identify changes in phosphorylation status of presynaptic proteins in resting and stimulated nerve terminals isolated from the brains of Wistar rats...
2016: ELife
Navita Somaiah, Melvin L K Chua, Sara Bourne, Frances Daley, Roger A' Hern, Otilia Nuta, Lone Gothard, Sue Boyle, Carsten Herskind, Ann Pearson, Jim Warrington, Sarah Helyer, Roger Owen, Kai Rothkamm, John Yarnold
AIM: To correlate residual double strand breaks (DSB) 24h after 4Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT). PATIENTS AND METHODS: Patients given whole breast RT ⩾5years earlier were identified on the basis of moderate/marked or minimal/no adverse effects despite the absence ('RT-Sensitive', RT-S) or presence ('RT-Resistant', RT-R) of variables predisposing to late adverse effects. Residual DSB were quantified in skin 24h after a 4Gy test dose in 20 RT-S and 15 RT-R patients...
May 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Hau Wei Khoo, Ying Ying Chua, John L T Chen
Salmonella vertebral osteomyelitis is an uncommon complication of Salmonella infection. We report a case of a 57-year-old transgender male who presented with lower back pain for a period of one month following a fall. Physical examination only revealed tenderness over the lower back with no neurological deficits. MRI of the thoracic and lumbar spine revealed a spondylodiscitis at T10-T11 and T12-L1 and right posterior epidural collection at the T9-T10 level. He underwent decompression laminectomy with segmental instrumentation and fusion of T8 to L3 vertebrae...
2016: Case Reports in Orthopedics
Otilia Nuta, Navita Somaiah, Sue Boyle, Melvin Lee Kiang Chua, Lone Gothard, John Yarnold, Kai Rothkamm, Carsten Herskind
Late normal tissue toxicity varies widely between patients and limits breast radiotherapy dose. Here we aimed to determine its relationship to DNA damage responses of fibroblast cultures from individual patients. Thirty-five breast cancer patients, with minimal or marked breast changes after breast-conserving therapy consented to receive a 4 Gy test irradiation to a small skin field of the left buttock and have punch biopsies taken from irradiated and unirradiated skin. Early-passage fibroblast cultures were established by outgrowth and irradiated in vitro with 0 or 4 Gy...
May 1, 2016: Cancer Letters
Oleksandr Yagensky, Tahere Kalantary Dehaghi, John Jia En Chua
Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins, often as vesicular packages, is mediated by motor complexes travelling along intracellular cytoskeletal networks. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by Dynein motors enables synapse-nuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins...
2016: Frontiers in Synaptic Neuroscience
Beyenech Binotti, Reinhard Jahn, John Jia En Chua
Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles-a process involving bulk movement of membrane and proteins. As key mediators of membrane trafficking, small GTPases from the Rab family of proteins play critical roles in this process by acting as molecular switches that dynamically interact with and regulate the functions of different sets of macromolecular complexes involved in each stage of the cycle...
2016: Cells
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