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https://www.readbyqxmd.com/read/27737633/huntingtin-associated-protein-1-eutherian-adaptation-from-a%C3%A2-trak-like-protein-conserved-gene-promoter-elements-and-localization-in-the-human-intestine
#1
Amanda L Lumsden, Richard L Young, Nektaria Pezos, Damien J Keating
BACKGROUND: Huntingtin-associated Protein 1 (HAP1) is expressed in neurons and endocrine cells, and is critical for postnatal survival in mice. HAP1 shares a conserved "HAP1_N" domain with TRAfficking Kinesin proteins TRAK1 and TRAK2 (vertebrate), Milton (Drosophila) and T27A3.1 (C. elegans). HAP1, TRAK1 and TRAK2 have a degree of common function, particularly regarding intracellular receptor trafficking. However, TRAK1, TRAK2 and Milton (which have a "Milt/TRAK" domain that is absent in human and rodent HAP1) differ in function to HAP1 in that they are mitochondrial transport proteins, while HAP1 has emerging roles in starvation response...
October 13, 2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27624941/regulation-of-l-type-ca2-channel-activity-and-insulin-secretion-by-huntingtin-associated-protein-1
#2
Jing-Ying Pan, Shijin Yuan, Tao Yu, Cong-Lin Su, Xiao-Long Liu, Jun He, He Li
Huntingtin associated protein 1 (Hap1) was originally identified as a protein that binds to the Huntington disease protein, huntingtin. Growing evidence has shown that Hap1 participates in intracellular trafficking via its association with various microtubule- dependent transporters and organelles. Recent studies also revealed that Hap1 is involved in exocytosis such as insulin release from pancreatic beta cells.However, the mechanism underlying the action of Hap1 on insulin release remains to be investigated...
September 13, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27519690/systematic-identification-of-genes-involved-in-metabolic-acid-stress-resistance-in-yeast-and-their-potential-as-cancer-targets
#3
John J Shin, Qurratulain Aftab, Pamela Austin, Jennifer A McQueen, Tak Poon, Shu Chen Li, Barry P Young, Calvin D Roskelley, Christopher J R Loewen
A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pumps, which expel the metabolic acid into the surrounding tumour environment, resulting in alkalization of intracellular pH and acidification of the tumour microenvironment. Nevertheless, we have only a limited understanding of the consequences of altered intracellular pH on cell physiology, or of the genes and pathways that respond to metabolic acid stress...
September 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27334583/opposing-roles-of-double-stranded-rna-effector-pathways-and-viral-defense-proteins-revealed-with-crispr-cas9-knockout-cell-lines-and-vaccinia-virus-mutants
#4
Ruikang Liu, Bernard Moss
UNLABELLED: Vaccinia virus (VACV) decapping enzymes and cellular exoribonuclease Xrn1 catalyze successive steps in mRNA degradation and prevent double-stranded RNA (dsRNA) accumulation, whereas the viral E3 protein can bind dsRNA. We showed that dsRNA and E3 colocalized within cytoplasmic viral factories in cells infected with a decapping enzyme mutant as well as with wild-type VACV and that they coprecipitated with antibody. An E3 deletion mutant induced protein kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2α) phosphorylation earlier and more strongly than a decapping enzyme mutant even though less dsRNA was made, leading to more profound effects on viral gene expression...
September 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27319755/behavioral-analysis-of-the-huntingtin-associated-protein-1-ortholog-trak-1-in-caenorhabditis-elegans
#5
Fran Norflus, Jingnan Bu, Evon Guyton, Claire-Anne Gutekunst
The precise role of huntingtin-associated protein 1 (HAP1) is not known, but studies have shown that it is important for early development and survival. A Caenorhabditis elegans ortholog of HAP1, T27A3.1 (also called trak-1), has been found and is expressed in a subset of neurons. Potential behavioral functions of three knockout lines of T27A3.1 were examined. From its suspected role in mice we hypothesize that T27A3.1 might be involved in egg hatching and early growth, mechanosensation, chemosensation, sensitivity to osmolarity, and synaptic transmission...
September 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27315547/huntingtin-associated-protein-1-is-a-synapsin-i-binding-protein-regulating-synaptic-vesicle-exocytosis-and-synapsin-i-trafficking
#6
Kimberly D Mackenzie, Amanda L Lumsden, Feng Guo, Michael D Duffield, Timothy Chataway, Yoon Lim, Xin-Fu Zhou, Damien J Keating
Huntingtin-associated protein-1 (HAP1) is involved in intracellular trafficking, vesicle transport, and membrane receptor endocytosis. However, despite such diverse functions, the role of HAP1 in the synaptic vesicle (SV) cycle in nerve terminals remains unclear. Here, we report that HAP1 functions in SV exocytosis, controls total SV turnover and the speed of vesicle fusion in nerve terminals and regulates glutamate release in cortical brain slices. We found that HAP1 interacts with synapsin I, an abundant neuronal phosphoprotein that associates with SVs during neurotransmitter release and regulates synaptic plasticity and neuronal development...
September 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27309588/characterization-of-axonal-transport-defects-in-drosophila-huntingtin-mutants
#7
Kurt R Weiss, J Troy Littleton
Polyglutamine expansion within Huntingtin (Htt) causes the fatal neurodegenerative disorder Huntington's Disease (HD). Although Htt is ubiquitously expressed and conserved from Drosophila to humans, its normal biological function is still being elucidated. Here we characterize a role for the Drosophila Htt homolog (dHtt) in fast axonal transport (FAT). Generation and expression of transgenic dHtt-mRFP and human Htt-mRFP fusion proteins in Drosophila revealed co-localization with mitochondria and synaptic vesicles undergoing FAT...
June 16, 2016: Journal of Neurogenetics
https://www.readbyqxmd.com/read/27151404/preliminary-evidence-of-differences-in-cadmium-tolerance-in-metal-free-stocks-of-the-standard-earthworm-test-species-eisenia-andrei-oligochaeta
#8
Patricks Voua Otomo, Laetitia Voua Otomo, Carlos C Bezuidenhout, Mark S Maboeta
To test whether metal-tolerant and metal-sensitive earthworm specimens could be an inherent part of metal-free earthworm populations, (i) we used DNA barcoding to identify and categorize earthworms from 8 populations of the standard test species Eisenia andrei, and (ii) the earthworms carrying three of the identified COI haplotypes (named Hap1, hap3 and Hap3) were paired up and exposed to Cd in order to assess the difference in Cd sensitivity between the breeding pairs. A total of six breeding pairs were exposed to 0, 25, 50 and 100 mg Cd/kg for 4 weeks at 20 °C...
August 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27103597/the-polymorphisms-of-a-mif-gene-and-their-association-with-vibrio-resistance-in-the-clam-meretrix-meretrix
#9
Linhu Zou, Baozhong Liu
Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine that mediates both innate and adaptive immune responses. In this study, a homolog of MIF was identified in the clam Meretrix meretrix. Ten SNPs in the DNA partial sequence of MmMIF were found to be significantly associated with Vibrio resistance (P < 0.05). Distinct expression patterns of MmMIF among different haplotypes were observed after Vibrio challenge. The results showed that haplotypes did not affect MmMIF expression in the negative control group, while the expression of MmMIF in clams with Hap1 and Hap1/Hap2 was significantly lower than that with Hap2 at 24 h in the PBS-injected group but significantly higher than that with Hap2 in the Vibrio-injected group...
September 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/26958867/self-setting-calcium-phosphate-cements-with-tunable-antibiotic-release-rates-for-advanced-antimicrobial-applications
#10
Shreya Ghosh, Victoria Wu, Sebastian Pernal, Vuk Uskoković
Osteomyelitis, an infectious disease predominantly tied to poor sanitary conditions in underdeveloped regions of the world, is in need of inexpensive, easily in situ synthesizable and administrable materials for its treatment. The results of this study stem from the attempt to create one such affordable and minimally invasive therapeutic platform in the form of a self-setting, injectable cement with a tunable drug release profile, composed of only nanoparticulate hydroxyapatite, the synthetic version of the bone mineral...
March 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26867216/a-new-mutation-hap1-2-reveals-a-c-terminal-domain-function-in-atmago-protein-and-its-biological-effects-in-male-gametophyte-development-in-arabidopsis-thaliana
#11
Kevin Cilano, Zachary Mazanek, Mahmuda Khan, Sarah Metcalfe, Xiao-Ning Zhang
The exon-exon junction complex (EJC) is a conserved eukaryotic multiprotein complex that examines the quality of and determines the availability of messenger RNAs (mRNAs) posttranscriptionally. Four proteins, MAGO, Y14, eIF4AIII and BTZ, function as core components of the EJC. The mechanisms of their interactions and the biological indications of these interactions are still poorly understood in plants. A new mutation, hap1-2. leads to premature pollen death and a reduced seed production in Arabidopsis. This mutation introduces a viable truncated transcript AtMagoΔC...
2016: PloS One
https://www.readbyqxmd.com/read/26820803/multiple-microrna-regulation-of-lipoprotein-lipase-gene-abolished-by-3-utr-polymorphisms-in-a-triglyceride-lowering-haplotype-harboring-p-ser474ter
#12
Cyrielle Caussy, Sybil Charrière, Aline Meirhaeghe, Jean Dallongeville, Etienne Lefai, Sophie Rome, Charlotte Cuerq, Vanessa Euthine, Mireille Delay, Oriane Marmontel, Mathilde Di Filippo, Michel Lagarde, Philippe Moulin, Christophe Marçais
BACKGROUND: Lipoprotein lipase (LPL) is a key enzyme in triglyceride (TG) metabolism. LPL gene single nucleotide polymorphisms (SNPs) are associated with TG concentrations however the functionality of many of these SNPs remains poorly understood. MicroRNAs (miR) exert post-transcriptional down-regulation and their target sequence on the 3'UTR may be altered by SNPs. We therefore investigated whether LPL 3'UTR SNPs could modulate plasma TG concentration through the alteration of miR binding-sites...
March 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26323396/novel-nucleotide-variations-haplotypes-structure-and-associations-with-growth-related-traits-of-goat-at-motif-binding-factor-atbf1-gene
#13
Xiaoyan Zhang, Xianfeng Wu, Wenchao Jia, Chuanying Pan, Xiangcheng Li, Chuzhao Lei, Hong Chen, Xianyong Lan
The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development. The goal of this study was to detect novel nucleotide variations and haplotypes structure of the ATBF1 gene, as well as to test their associations with growth-related traits in goats...
October 2015: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26297452/the-roles-of-tetrapyrroles-in-plastid-retrograde-signaling-and-tolerance-to-environmental-stresses
#14
Zhong-Wei Zhang, Gong-Chang Zhang, Feng Zhu, Da-Wei Zhang, Shu Yuan
This review provides new insights that tetrapyrrole signals play important roles in nuclear gene expression, chloroplast development and plant's resistance to environmental stresses. Higher plants contain many tetrapyrroles, including chlorophyll (Chl), heme, siroheme, phytochromobilin and some of their precursors, all of which have important biological functions. Genetic and physiological studies indicated that tetrapyrrole (mainly Mg-protoporphyrin IX) retrograde signals control photosynthesis-associated nuclear gene (PhANG) expression...
December 2015: Planta
https://www.readbyqxmd.com/read/26257585/effect-of-the-materials-properties-of-hydroxyapatite-nanoparticles-on-fibronectin-deposition-and-conformation
#15
Fei Wu, Debra D W Lin, Jin Ho Chang, Claudia Fischbach, Lara A Estroff, Delphine Gourdon
Hydroxyapatite (HAP, Ca10(PO4)6(OH)2) nanoparticles with controlled materials properties have been synthesized through a two-step hydrothermal aging method to investigate fibronectin (Fn) adsorption. Two distinct populations of HAP nanoparticles have been generated: HAP1 particles had smaller size, plate-like shape, lower crystallinity, and more negative ζ potential than HAP2 particles. We then developed two-dimensional platforms containing HAP and Fn and analyzed both the amount and the conformation of Fn via Förster resonance energy transfer (FRET) at various HAP concentrations...
May 6, 2015: Crystal Growth & Design
https://www.readbyqxmd.com/read/26225956/molecular-characterization-of-bovine-smo-gene-and-effects-of-its-genetic-variations-on-body-size-traits-in-qinchuan-cattle-bos-taurus
#16
Ya-Ran Zhang, Lin-Sheng Gui, Yao-Kun Li, Bi-Jie Jiang, Hong-Cheng Wang, Ying-Ying Zhang, Lin-Sen Zan
Smoothened (Smo)-mediated Hedgehog (Hh) signaling pathway governs the patterning, morphogenesis and growth of many different regions within animal body plans. This study evaluated the effects of genetic variations of the bovine SMO gene on economically important body size traits in Chinese Qinchuan cattle. Altogether, eight single nucleotide polymorphisms (SNPs: 1-8) were identified and genotyped via direct sequencing covering most of the coding region and 3'UTR of the bovine SMO gene. Both the p.698Ser.>Ser...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26000918/molecular-characterization-of-genes-modifying-the-age-at-onset-in-huntington-s-disease-in-uruguayan-patients
#17
Marcelo Vital, Estela Bidegain, Victor Raggio, Patricia Esperon
Huntington's Disease (HD) is an hereditary neurodegenerative disorder. The genetic cause is an expansion of CAG repeats located in the IT15 gene. Though the number of CAG repeats ((CAG)n) can largely explain the age at onset of symptoms (AAO), a percentage of its variation could be attributed to modifier genes and to environmental factors. The study aimed to evaluate the influence of genetic modifiers of the AAO of HD including: (CAG)n and del2642 in the IT15 gene, ADORA2A rs5751876, HAP1 rs4523977, PGC1-α rs7665116 and UCH-L1 rs5030732...
May 22, 2015: International Journal of Neuroscience
https://www.readbyqxmd.com/read/25935543/loci-associated-with-adult-stature-also-affect-calf-birth-survival-in-cattle
#18
Goutam Sahana, Johanna K Höglund, Bernt Guldbrandtsen, Mogens S Lund
BACKGROUND: Understanding the underlying pleiotropic relationships among quantitative traits is necessary in order to predict correlated responses to artificial selection. The availability of large-scale next-generation sequence data in cattle has provided an opportunity to examine whether pleiotropy is responsible for overlapping QTL in multiple economic traits. In the present study, we examined QTL affecting cattle stillbirth, calf size, and adult stature located in the same genomic region...
2015: BMC Genetics
https://www.readbyqxmd.com/read/25932641/association-of-mmp-9-haplotypes-and-timp-1-polymorphism-with-spontaneous-deep-intracerebral-hemorrhage-in-the-taiwan-population
#19
Wei-Min Ho, Chiung-Mei Chen, Yun-Shien Lee, Kuo-Hsuan Chang, Huei-Wen Chen, Sien-Tsong Chen, Yi-Chun Chen
BACKGROUND: Spontaneous deep intracerebral hemorrhage (SDICH) is a devastating stroke subtype. The causes of SDICH are heterogeneous. Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the development of aneurysm and may increase risks of intracerebral hemorrhage. MMP activities are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). We analyzed the genetic variants of MMP-9 and TIMP-1 and SDICH susceptibility...
2015: PloS One
https://www.readbyqxmd.com/read/25875952/postnatal-loss-of-hap1-reduces-hippocampal-neurogenesis-and-causes-adult-depressive-like-behavior-in-mice
#20
Jianxing Xiang, Sen Yan, Shi-Hua Li, Xiao-Jiang Li
Depression is a serious mental disorder that affects a person's mood, thoughts, behavior, physical health, and life in general. Despite our continuous efforts to understand the disease, the etiology of depressive behavior remains perplexing. Recently, aberrant early life or postnatal neurogenesis has been linked to adult depressive behavior; however, genetic evidence for this is still lacking. Here we genetically depleted the expression of huntingtin-associated protein 1 (Hap1) in mice at various ages or in selective brain regions...
April 2015: PLoS Genetics
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