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Triglycerides AND Coenzyme A

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https://www.readbyqxmd.com/read/29660431/electroacupuncture-ameliorates-poloxamer-407-induced-hyperlipidemia-through-suppressing-hepatic-srebp-2-expression-in-rats
#1
Mijung Yeom, Jinhee Park, Bombi Lee, Hyang Sook Lee, Hi-Joon Park, Ran Won, Hyejung Lee, Dae-Hyun Hahm
AIMS: Acupuncture, particularly electroacupuncture (EA) has been shown to have the lipid-lowering effects, but not completely investigated. The present study was aimed to examine whether EA could attenuate poloxamer-407 (P-407)-induced hyperlipidemia in the rats and to investigate its potential mechanisms. MAIN METHODS: Rats received P-407 (0.4 g/kg, i.p.) to induce hyperlipidemia. EA was performed at ST36 and ST40 acupoints a total of three times with 12 h-interval starting 1 h before the P-407 injection at 0...
April 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29645002/proteomics-analysis-reveals-a-potential-new-target-protein-for-the-lipid-lowering-effect-of-berberine8998
#2
Cheng-Yin Yu, Gang-Yi Liu, Xiao-Hui Liu, Yu-Zhou Gui, Hai-Ming Liu, Hong-Chao Zheng, Darek C Gorecki, Asmita V Patel, Chen Yu, Yi-Ping Wang
Berberine8998 is a newly synthesized berberine derivative with better lipid-lowering activity and improved absorption. The objective of this study was to investigate the effects of berberine8998 on serum cholesterol and lipid levels in vivo and to examine the mechanisms involved. Hamsters on high-fat diet (HFD) were administered berberine or berberine8998 (50 mg·kg-1 ·d-1 , ig) for 3 weeks. Berberine8998 administration significantly lowered the total cholesterol, triglycerides and LDL-C levels in HFD hamsters...
April 12, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29623830/the-effects-of-coenzyme-q10-supplementation-on-lipid-profiles-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
Nasrin Sharifi, Reza Tabrizi, Mahmood Moosazadeh, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Akbari, Maryam Chamani, Fariba Kolahdooz, Zatollah Asemi
BACKGROUND AND OBJECTIVE: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders...
April 5, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29622007/synergistic-effect-of-phytochemicals-on-cholesterol-metabolism-and-lipid-accumulation-in-hepg2-cells
#4
Ennian Leng, Yuan Xiao, Zhentao Mo, Yiqi Li, Yueyue Zhang, Xiaosi Deng, Min Zhou, Chaochao Zhou, Zengxuan He, Jingyi He, Lu Xiao, Junming Li, Wenna Li
BACKGROUND: Crocin (CRO), chlorogenic acid (CGA), geniposide (GEN), and quercetin (QUE) are all natural compounds with anti-obesity properties, in particular, hypolipidemic effects, which have been widely used for the treatment of obesity-related metabolic diseases. However, it is not yet known whether these compounds interact synergistically. Here, we investigated the effects and molecular mechanisms of CRO, CGA, GEN, QUE, and a combination of all four compounds (CCGQ), on lipid accumulation in human hepatoma (HepG2 cells)...
April 5, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29550812/lack-of-clc-2-alleviates-high-fat-diet-induced-insulin-resistance-and-non-alcoholic-fatty-liver-disease
#5
Dongxia Fu, Haibin Cui, Yunna Zhang
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. This study aims to investigate whether chloride channel 2 (ClC-2) is involved in high fat diet (HFD)-induced NAFLD and possible molecular mechanisms. METHODS: ClC-2 expression was liver-specifically downregulated using adeno-associated virus in C57BL/6 mice treated with a chow diet or HFD for 12 weeks. Peripheral blood and liver tissues were collected for biochemical and pathological estimation respectively...
March 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29524401/ablation-of-prolactin-receptor-increases-hepatic-triglyceride-accumulation
#6
Shanshan Shao, Zhenyu Yao, Jiayu Lu, Yongfeng Song, Zhao He, Chunxiao Yu, Xiaoming Zhou, Lifang Zhao, Jiajun Zhao, Ling Gao
Increasing prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide has necessitated a more thorough understanding of it and expanded the scope of research in this field. Women are more resistant to NAFLD than men despite equal exposure to major risk factors, such as obesity or hyperlipidemia. Female resistance is hormone-dependent, as evidenced by the sharp increase in NAFLD incidence in post-menopausal women who do not take hormone replacement therapy. Here, we found that the estrogen-responsive pituitary hormone prolactin (PRL), through specific PRL receptor (PRLR), down-regulates hepatic triglyceride (TG) accumulation...
March 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29507904/improved-oxygenation-dramatically-alters-metabolism-and-gene-expression-in-cultured-primary-mouse-hepatocytes
#7
Eduardo H Gilglioni, Jung-Chin Chang, Suzanne Duijst, Simei Go, Aziza A A Adam, Ruurdtje Hoekstra, Arthur J Verhoeven, Emy L Ishii-Iwamoto, Ronald P J Oude Elferink
Primary hepatocyte culture is an important in vitro system for the study of liver functions. In vivo , hepatocytes have high oxidative metabolism. However, oxygen supply by means of diffusion in in vitro static cultures is much less than that by blood circulation in vivo . Therefore, we investigated whether hypoxia contributes to dedifferentiation and deregulated metabolism in cultured hepatocytes. To this end, murine hepatocytes were cultured under static or shaken (60 revolutions per minute) conditions in a collagen sandwich...
March 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29454678/treatment-of-coenzyme-q10-for-24-weeks-improves-lipid-and-glycemic-profile-in-dyslipidemic-individuals
#8
Peiwen Zhang, Chen Yang, Honghui Guo, Jiaji Wang, Shengqiang Lin, Huamei Li, Yan Yang, Wenhua Ling
BACKGROUND: The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown benefit. However, the effect of CoQ10 as a primary preventive agent against cardiovascular diseases (CVDs) has not been well studied. OBJECTIVE: The objective of this study was to investigate the effect of CoQ10 on CVD risk factors in dyslipidemic patients. METHODS: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic subjects without taking any hypoglycemic or hypolipidemic drugs were administrated to 120 mg CoQ10 or placebo daily for 24 weeks...
March 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29441875/influence-of-slco1b1-polymorphisms-on-atorvastatin-efficacy-and-safety-in-macedonian-subjects
#9
K Mladenovska, A Daka Grapci, M Vavlukis, A Kapedanovska, A Eftimov, N Matevska Geshkovska, D Nebija, A J Dimovski
Atorvastatin, as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a widely prescribed medication for the treatment of dyslipidemia. However, despite its clinical efficacy in reducing major cardiovascular events, a wide inter-individual variability in its response exists. Several studies in this area point to the effect of polymorphisms in the solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the multiple organic anion-transporting polypeptide 1B1 (OATP1B1) involved in hepatic uptake of atorvastatin...
May 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29425798/the-antioxidant-status-of-coenzyme-q10-and-vitamin-e-in-children-with-type-1-diabetes
#10
Usama M Alkholy, Nermin Abdalmonem, Ahmed Zaki, Mohamed A Elkoumi, Mustafa I Abu Hashim, Maha A A Basset, Hossam E Salah
OBJECTIVE: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. METHOD: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups...
February 6, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29424317/novel-hypolipidaemic-drugs-mechanisms-of-action-and-main-metabolic-effects
#11
Theodosios D Filippatos, Angelos Liontos, Eliza C Christopoulou, Moses S Elisaf
Over the last 3 decades, hypolipidaemic treatment has significantly reduced both cardiovascular (CV) risk and events, with statins being the cornerstone of this achievement. Nevertheless, residual CV risk and unmet goals in hypolipidaemic treatment make novel options necessary. Recently marketed monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9) have shown the way towards innovation, while other ways of PCSK9 inhibition like small interfering RNA (Inclisiran) are already being tested...
February 8, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29365333/effects-of-coenzyme-q10-supplementation-on-serum-values-of-gamma-glutamyl-transferase-pseudocholinesterase-bilirubin-ferritin-and-high-sensitivity-c-reactive-protein-in-women-with-type-2-diabetes
#12
Mahsa Gholami, Mohammad Reza Rezvanfar, Mostafa Delavar, Mahdi Abdollahi, Ali Khosrowbeygi
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a disease associated with increased oxidative stress which results from mitochondrial dysfunction. Coenzyme Q10 (CoQ10 ) is an essential antioxidant for energy production in mitochondria. The purpose of this randomized double-blind clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of gamma-glutamyl transferase (GGT), pseudocholinesterase (PchE), bilirubin, ferritin, and high-sensitivity c-reactive protein (hs-CRP) and metabolic syndrome biomarkers in women with T2DM...
January 24, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29165714/blood-lipid-genetic-scores-the-hmgcr-gene-and-cancer-risk-a-mendelian-randomization-study
#13
Marju Orho-Melander, George Hindy, Signe Borgquist, Christina-Alexandra Schulz, Jonas Manjer, Olle Melander, Tanja Stocks
Background: It is unclear whether there are causal associations between blood lipids, statin use and cancer risks. Under certain assumptions, Mendelian randomization analysis of a genetic marker for an exposure eliminates reverse causation and confounding. Methods: We applied Mendelian randomization analysis to genetic scores, comprising 26-41 single-nucleotide polymorphisms (SNPs), as instrumental variables (IVs) for triglycerides and low- and high-density lipoprotein cholesterol (LDLC, HDLC), using a prospective cohort of 26 904 individuals in which there were 6607 incident cancers...
November 20, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29152131/microrna-130b-attenuates-dexamethasone-induced-increase-of-lipid-accumulation-in-porcine-preadipocytes-by-suppressing-ppar-%C3%AE-expression
#14
Shifeng Pan, Yixin Cui, Xuan Dong, Tangjie Zhang, Hua Xing
In this study, two experiments were conducted to determine the role of miR-130b in dexamethasone (DEX)-induced lipid accumulation. Porcine preadipocytes were treated with 10-6 M DEX for 48 h to investigate effects of DEX in lipid accumulation. Next, in order to illustrate the regulatory role of miR-130b on lipid accumulation induced by DEX, miRNA scrambled control (miR-SC), miR-130b overexpression plasmid and miR-130b inhibitor were respectively transfected into porcine preadipocytes at 24 h before DEX treatment for 48 h (miR-SC-DEX, miR-130b-DEX and miR-130b-inhibitor-DEX)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147490/hypolipidemic-effects-of-total-flavonoide-extracted-from-the-leaves-of-actinidiakolomikta-in-rats-fed-a-high-fat-diet
#15
Zhenxiang Yu, Huali Xu, Xiaofeng Yu, Dayun Sui, Guangzhu Lin
Objectives: This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods: Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperlipedemic diet supplemented with TFAK (50, 100 and 200 mg/kg) and simvastatin (30 mg/kg) groups. The rats were administrated TFAK by oral for 28 days...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29104625/high-expression-of-long-chain-acyl-coenzyme-a-synthetase-1-in-peripheral-blood-may-be-a-molecular-marker-for-assessing-the-risk-of-acute-myocardial-infarction
#16
Liping Yang, Yushuang Yang, Daoyuan Si, Kaiyao Shi, Dongna Liu, Heyu Meng, Fanbo Meng
The current study aimed to investigate whether the increased expression of long chain acyl-coenzymeA synthetase 1 (ACSL1) in peripheral blood leukocytes (PBL) may be a molecular marker for the genetic evaluation of acute myocardial infarction (AMI). The mechanism of action of ACSL1 in the pathogenesis of AMI was also investigated. A total of 75 patients with AMI and 70 individuals without coronary heart disease were selected to participate in the present study. The demographic and clinical information of the enrolled subjects was recorded...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29098469/supplementation-of-arachidonic-acid-rich-oil-in-european-sea-bass-juveniles-dicentrarchus-labrax-diets-effects-on-growth-performance-tissue-fatty-acid-profile-and-lipid-metabolism
#17
S Torrecillas, M B Betancor, M J Caballero, F Rivero, L Robaina, M Izquierdo, D Montero
The aim of this study was to evaluate the effects of increasing dietary arachidonic acid (ARA) levels (from 1 to 6% of total fatty acids) on European sea bass (Dicentrarchus labrax) juveniles' growth performance, tissue fatty acid profile, liver morphology as well as long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis, triglyceride and cholesterol synthesis and lipid transport. A diet with total fish oil (FO) replacement and defatted fish meal (FM) containing a 0.1-g ARA g(-1) diet was added to the experimental design as a negative control diet...
November 2, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29074218/avasimibe-a-novel-hepatitis-c-virus-inhibitor-that-targets-the-assembly-of-infectious-viral-particles
#18
Longbo Hu, Jinqian Li, Hua Cai, Wenxia Yao, Jing Xiao, Yi-Ping Li, Xiu Qiu, Huimin Xia, Tao Peng
Direct-acting antivirals (DAAs), which target hepatitis C virus (HCV) proteins, have exhibited impressive efficacy in the management of chronic hepatitis C. However, the concerns regarding high costs, drug resistance mutations and subsequent unexpected side effects still call for the development of host-targeting agents (HTAs) that target host factors involved in the viral life cycle and exhibit pan-genotypic antiviral activity. Given the close relationship between lipid metabolism and the HCV life cycle, we investigated the anti-HCV activity of a series of lipid-lowering drugs that have been approved by government administrations or proven safety in clinical trials...
October 23, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28982243/solanum-nigrum-polyphenol-extracts-inhibit-hepatic-inflammation-oxidative-stress-and-lipogenesis-in-high-fat-diet-treated-mice
#19
Ja-Jen Chang, Dai-Jung Chung, Yi-Ju Lee, Bo-Han Wen, Hsing-Yu Jao, Chau-Jong Wang
Patients with diabetes, obesity, and hyperlipidemia are all high-risk groups for fatty liver; however, the mechanism of fatty liver formation is not completely understood. Studies have indicated that abnormal fat metabolism, oxidative stress, and insulin resistance are positively correlated with peroxidation and abnormal cytokine production. Recent studies have revealed that Solanum nigrum extracts (SNE) possess anti-inflammatory, antioxidation, antihyperlipidemia, and liver protection abilities. Therefore, the present study investigated the in vivo and in vitro effects of an SNE on nonalcoholic fatty liver (NAFL)-induced hepatitis...
October 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#20
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycemia and protect from diet- and genetically-induced obesity in rodents and nonhuman primates. However, it is currently unknown which tissue(s) contribute to this glucose-lowering effect...
October 1, 2017: Endocrinology
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