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chemotherapy and cognition

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https://www.readbyqxmd.com/read/28327626/altered-resting-state-hippocampal-functional-networks-associated-with-chemotherapy-induced-prospective-memory-impairment-in-breast-cancer-survivors
#1
Huaidong Cheng, Wen Li, Liang Gong, Han Xuan, Zhonglian Huang, Hong Zhao, Long Sheng Wang, Kai Wang
In this study, we aimed to investigate the intrinsic hippocampal functional connectivity (FC) network and its relationship with prospective memory in patients with breast cancer suffering from chemotherapy-induced cognitive impairment (CICI). Thirty-four breast cancer patients before and after adjuvant chemotherapy (CB and CC, respectively) and 31 age- and education-matched cognitively normal (CN) women were recruited and subjected to a prospective memory task and a resting-state functional magnetic resonance imaging scan...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28316129/cognitive-compensatory-processes-of-older-clinically-fit-patients-with-hematologic-malignancies-undergoing-chemotherapy-a-longitudinal-cohort-study
#2
Yves Libert, Cindy Borghgraef, Yves Beguin, Nicole Delvaux, Martine Devos, Chantal Doyen, Stéphanie Dubruille, Anne-Marie Etienne, Aurore Liénard, Isabelle Merckaert, Christine Reynaert, Jean-Louis Slachmuylder, Nicole Straetmans, Eric Van Den Neste, Dominique Bron, Darius Razavi
OBJECTIVE: Despite the well-known negative impacts of cancer and anticancer therapies on cognitive performance, little is known about the cognitive compensatory processes of older patients with cancer. This study was designed to investigate the cognitive compensatory processes of older, clinically-fit patients with hematologic malignancies undergoing chemotherapy. METHODS: We assessed 89 consecutive patients (age ≥ 65 years) without severe cognitive impairment and 89 age-, sex-, and education level-matched healthy controls...
March 18, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28293478/disrupted-brain-network-functional-dynamics-and-hyper-correlation-of-structural-and-functional-connectome-topology-in-patients-with-breast-cancer-prior-to-treatment
#3
Shelli R Kesler, Marjorie Adams, Melissa Packer, Vikram Rao, Ashley M Henneghan, Douglas W Blayney, Oxana Palesh
INTRODUCTION: Several previous studies have demonstrated that cancer chemotherapy is associated with brain injury and cognitive dysfunction. However, evidence suggests that cancer pathogenesis alone may play a role, even in non-CNS cancers. METHODS: Using a multimodal neuroimaging approach, we measured structural and functional connectome topology as well as functional network dynamics in newly diagnosed patients with breast cancer. Our study involved a novel, pretreatment assessment that occurred prior to the initiation of any cancer therapies, including surgery with anesthesia...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28290076/brain-functional-connectivity-in-lung-cancer-population-an-exploratory-study
#4
M Simó, X Rifà-Ros, L Vaquero, P Ripollés, N Cayuela, J Jové, A Navarro, F Cardenal, J Bruna, Antoni Rodríguez-Fornells
The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28288921/therapy-for-recurrent-high-grade-gliomas-results-of-a-prospective-multicenter-study-on-health-related-quality-of-life
#5
Linda Stöckelmaier, Mirjam Renovanz, Jochem König, Katrin Nickel, Anne-Katrin Hickmann, Regine Mayer-Steinacker, Minou Nadji-Ohl, Oliver Ganslandt, Lars Bullinger, Christian Rainer Wirtz, Jan Coburger
OBJECTIVE: To assess impact of therapy on patients' health-related quality of life (HRQoL) in recurrent high-grade glioma (HGG) in an unselected cohort. METHODS: In this prospective multicenter study, we analyzed EORTC QLQ-C30 and BN20 questionnaires of 92 patients within one year after diagnosis of tumor recurrence of a HGG and respective treatment. We evaluated the influence of re-radiation, second and third-line chemotherapies and number of recurrent surgeries on sum scores for functioning, symptoms and total score as well as on sub scores for functioning and neurological symptoms using multivariate mixed models and descriptive statistics...
March 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28276853/worsening-of-rest-activity-circadian-rhythm-and-quality-of-life-in-female-breast-cancer-patients-along-progression-of-chemotherapy-cycles
#6
Armiya Sultan, Vivek Choudhary, Arti Parganiha
Chemotherapy and its associated side effects can induce the disruption of circadian rest-activity rhythm and may have negative consequences on health-related quality of life (HRQoL) of cancer patients. In the current study, repeated-measures cross-sectional design was implemented to determine the status of circadian rest-activity rhythm and to assess the HRQoL of newly diagnosed female breast cancer patients those were planned to receive six cycles of chemotherapy. Rest activity and HRQoL were assessed in twenty-five patients during chemotherapy cycles 1st (C1), 3rd (C3), and 6th (C6) immediately after they reported to the outdoor ward of the Regional Cancer Center, Pt...
February 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28274254/the-use-of-randomisation-based-efficacy-estimators-in-non-inferiority-trials
#7
David Gillespie, Daniel Farewell, Peter Barrett-Lee, Angela Casbard, Anthony Barney Hawthorne, Chris Hurt, Nick Murray, Chris Probert, Rachel Stenson, Kerenza Hood
BACKGROUND: In a non-inferiority (NI) trial, analysis based on the intention-to-treat (ITT) principle is anti-conservative, so current guidelines recommend analysing on a per-protocol (PP) population in addition. However, PP analysis relies on the often implausible assumption of no confounders. Randomisation-based efficacy estimators (RBEEs) allow for treatment non-adherence while maintaining a comparison of randomised groups. Fischer et al. have developed an approach for estimating RBEEs in randomised trials with two active treatments, a common feature of NI trials...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28267750/changes-in-brain-activation-in-breast-cancer-patients-depend-on-cognitive-domain-and-treatment-type
#8
Sanne Menning, Michiel B de Ruiter, Dick J Veltman, Willem Boogerd, Hester S A Oldenburg, Liesbeth Reneman, Sanne B Schagen
BACKGROUND: Cognitive problems in breast cancer patients are common after systemic treatment, particularly chemotherapy. An increasing number of fMRI studies show altered brain activation in breast cancer patients after treatment, suggestive of neurotoxicity. Previous prospective fMRI studies administered a single cognitive task. The current study employed two task paradigms to evaluate whether treatment-induced changes depend on the probed cognitive domain. METHODS: Participants were breast cancer patients scheduled to receive systemic treatment (anthracycline-based chemotherapy +/- endocrine treatment, n = 28), or no systemic treatment (n = 24) and no-cancer controls (n = 31)...
2017: PloS One
https://www.readbyqxmd.com/read/28266346/chemotherapy-related-cognitive-impairment-or-%C3%A2-%C3%A2-chemobrain%C3%A2-%C3%A2-concept-and-state-of-art
#9
Flavie Bompaire, Thomas Durand, Isabelle Léger-Hardy, Dimitri Psimaras, Damien Ricard
Cognitive complaints are frequent in patients who received chemotherapy for a non-CNS cancer. These observations have been described as « chemobrain ». However, studies results are contradictory concerning the implication of chemotherapy in the onset of cognitive defects. Moreover, other factors as mood, anxiety and fatigue are often associated in this population and could be confounding. This article present principal results of research in human experiencing chemobrain, concerning clinical presentation, neuropsychological examination, imaging techniques and treatment possibilities...
March 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28259598/tropisetron-sensitizes-%C3%AE-7-containing-nicotinic-receptors-to-low-levels-of-acetylcholine-in%C3%A2-vitro-and-improves-memory-related-task-performance-in-young-and-aged-animals
#10
Patrick M Callahan, Daniel Bertrand, Sonia Bertrand, Marc R Plagenhoef, Alvin V Terry
Tropisetron, a 5-HT3 receptor antagonist commonly prescribed for chemotherapy-induced nausea and vomiting also exhibits high affinity, partial agonist activity at α7 nicotinic acetylcholine receptors (α7 nAChRs). α7 nAChRs are considered viable therapeutic targets for neuropsychiatric disorders such as Alzheimer's disease (AD). Here we further explored the nAChR pharmacology of tropisetron to include the homomeric α7 nAChR and recently characterized heteromeric α7β2 nAChR (1:10 ratio) and we evaluated its cognitive effects in young and aged animals...
March 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28255868/biosimilar-epoetin-alfa-increases-haemoglobin-levels-and-brings-cognitive-and-socio-relational-benefits-to-elderly-transfusion-dependent-multiple-myeloma-patients-results-from-a-pilot-study
#11
Roberto Castelli, Simona Sciara, Giorgio Lambertenghi Deliliers, Giuseppe Pantaleo
Anaemia is a complication reported in up to 70% of the multiple myeloma patients (MM), with remarkable clinical, cognitive and socio-relational consequences. Anaemia relates to the course of MM, normalizing in patients during remission and reappearing in relapsing/non-responding patients. In a pilot study with 31 patients with MM and transfusion-dependent anaemia, we evaluated the effects of Binocrit (biosimilar epoetin alfa) on transfusions, haemoglobin levels, mental status (mini-mental state evaluation) and the patients' social-relational functioning and quality of life (QoL)...
March 2, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28247032/effect-of-a-patient-tailored-integrative-medicine-program-on-gastro-intestinal-concerns-and-quality-of-life-in-patients-with-breast-and-gynecologic-cancer
#12
Ilanit Shalom-Sharabi, Noah Samuels, Ofer Lavie, Efraim Lev, Lital Keinan-Boker, Elad Schiff, Eran Ben-Arye
CONTEXT AND OBJECTIVES: This study was conducted to assess the impact of a patient-tailored complementary/integrative medicine (CIM) program on gastro-intestinal (GI) symptoms and other concerns in female patients with breast/gynecological cancer undergoing chemotherapy. METHODS: Patients with breast/gynecological cancer reporting GI-related concerns were referred to an integrative physician (IP) consultation. The treatment group included patients agreeing to attend the consultation; controls those who did not...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28239531/brain-structure-working-memory-and-response-inhibition-in-childhood-leukemia-survivors
#13
Ellen van der Plas, Russell J Schachar, Johann Hitzler, Jennifer Crosbie, Sharon L Guger, Brenda J Spiegler, Shinya Ito, Brian J Nieman
INTRODUCTION: Survival rates for children with acute lymphoblastic leukemia (ALL) approach 95%. At the same time, there is growing concern that chemotherapy causes alterations in brain development and cognitive abilities. We performed MRI measurements of white and gray matter volume to explore how variation in brain structure may be related to cognitive abilities in ALL survivors and healthy controls. METHODS: The sample included 24 male ALL survivors who had completed contemporary treatment 3-11 years prior, and 21 age- and sex-matched controls...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28222075/a-pilot-study-of-a-cognitive-behavioral-intervention-for-breast-cancer-survivors
#14
Heather Becker, Ashley M Henneghan, Deborah L Volker, Sabrina Q Mikan
PURPOSE/OBJECTIVES: To test combining a group intervention to build self-efficacy for using compensatory strategies and lifestyle adjustments with brain-training practice to improve cognition.
. DESIGN: A quasiexperimental design.
. SETTING: Texas Oncology, a community oncology practice in Austin.
. SAMPLE: 20 women aged 35-65 years, who had finished chemotherapy at least three months before the study, were within five years of completing all treatment, and had self-reported cognitive concerns...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28219113/personality-coping-and-social-support-as-predictors-of-long-term-quality-of-life-trajectories-in-older-breast-cancer-survivors-calgb-protocol-369901-alliance
#15
Estrella Durá-Ferrandis, Jeanne S Mandelblatt, Jonathan Clapp, George Luta, Leigh Anne Faul, Gretchen Kimmick, Harvey J Cohen, Rachel L Yung, Arti Hurria
OBJECTIVE: To determine long-term quality-of-life (QoL) trajectories among breast cancer survivors aged 65+ ("older") evaluating the effects of personality and social support. METHODS: Older women (N = 1280) newly diagnosed with invasive, non-metastatic breast cancer completed baseline assessments. Follow-up data were collected 6 and 12 months later and then annually for up to 7 years (median 4.5 years). QoL was assessed using EORTC-QLQC30 emotional, physical, and cognitive scales...
February 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28208082/cognitive-impairment-in-the-first-year-after-breast-cancer-diagnosis-a-prospective-cohort-study
#16
Mariana Ramalho, Filipa Fontes, Luís Ruano, Susana Pereira, Nuno Lunet
OBJECTIVES: The objective of this study was to assess the relation between cancer treatments and incident cognitive impairment in breast cancer patients, taking into account the levels of anxiety before treatment. MATERIALS AND METHODS: We conducted a prospective cohort study with 418 newly diagnosed breast cancer patients with no cognitive impairment, defined as values at least 1.5 standard deviations below age- and education-adjusted cut-offs in the Montreal Cognitive Assessment (MoCA), at baseline...
April 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28193133/integrative-therapeutic-approaches-for-the-management-and-control-of-nausea-in-children-undergoing-cancer-treatment
#17
Tha'er G Momani, Donna L Berry
Chemotherapy-induced nausea and vomiting (CINV) continues to be a common symptom experienced by children undergoing cancer treatment despite the use of contemporary antiemetics. Integrative therapeutic approaches in addition to standard pharmacologic antiemetic regimes offer potential to control CINV. The purpose of this review was to identify current evidence on integrative therapeutic approaches for the control of CINV in children with cancer. Online search engines (PubMed, CINAHL, PsychINFO) were queried using MESH terms...
February 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28187964/brain-perfusion-and-diffusion-abnormalities-in-children-treated-for-posterior-fossa-brain-tumors
#18
Matthew D Li, Nils D Forkert, Palak Kundu, Cheryl Ambler, Robert M Lober, Terry C Burns, Patrick D Barnes, Iris C Gibbs, Gerald A Grant, Paul G Fisher, Samuel H Cheshier, Cynthia J Campen, Michelle Monje, Kristen W Yeom
OBJECTIVE: To compare cerebral perfusion and diffusion in survivors of childhood posterior fossa brain tumor with neurologically normal controls and correlate differences with cognitive dysfunction. STUDY DESIGN: We analyzed retrospectively arterial spin-labeled cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) in 21 patients with medulloblastoma (MB), 18 patients with pilocytic astrocytoma (PA), and 64 neurologically normal children. We generated ANCOVA models to evaluate treatment effects on the cerebral cortex, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, and cerebral white matter at time points an average of 5...
February 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28159005/the-women-s-wellness-after-cancer-program-a-multisite-single-blinded-randomised-controlled-trial-protocol
#19
Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells, Sarah Balaam, Alexandra L McCarthy
BACKGROUND: Despite advances in cancer diagnosis and treatment have significantly improved survival rates, patients post-treatment-related health needs are often not adequately addressed by current health services. The aim of the Women's Wellness after Cancer Program (WWACP), which is a digitised multimodal lifestyle intervention, is to enhance health-related quality of life in women previously treated for blood, breast and gynaecological cancers. METHODS: A single-blinded, multi-centre randomized controlled trial recruited a total of 330 women within 24 months of completion of chemotherapy (primary or adjuvant) and/or radiotherapy...
February 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28156632/end-of-life-care-for-glioblastoma-multiforme-gbm-patients-at-a-large-academic-center
#20
Xiao Wang, Jiangxia Wang, Anne Evans, W Anthony Riley, Thomas J Smith
56 Background: GBM is a uniformly fatal disease with average survival of < 3 years and universal cognitive problems, making advance care planning paramount. End of life (EOL) patterns of GBM care in the US have not been studied. We examined care in a cohort of GBM and brain tumor (BT) patients as part of a program to provide individual provider feedback about EOL care. METHODS: We reviewed the care of all GBM patients over 3 years with a random sample of 100, and a 5-yr subset of 45 who received their care at Gilchrist Hospice (GH), our largest provider...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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