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chemotherapy and cognition

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https://www.readbyqxmd.com/read/28645952/title-cervical-cancer-survivors-perceived-cognitive-complaints-and-supportive-care-needs-in-mainland-china-a-qualitative-study
#1
Yingchun Zeng, Andy Sk Cheng, Xiangyu Liu, Chetwyn Ch Chan
OBJECTIVES: This study explores Chinese cervical cancer survivors' perceived cognitive complaints and relevant supportive care needs after primary cancer treatment. DESIGN: This study utilised a qualitative research design. A semi-structured interview was used to probe cervical cancer patients' perceived cognitive complaints and supportive care needs. SETTING: This study was conducted at a secondary cancer care centre located in South China...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28635986/optimism-symptom-distress-illness-appraisal-and-coping-in-patients-with-advanced-stage-cancer-diagnoses-undergoing-chemotherapy-treatment
#2
Catherine Sumpio, Sangchoon Jeon, Laurel L Northouse, M Tish Knobf
PURPOSE/OBJECTIVES: To explore the relationships between optimism, self-efficacy, symptom distress, treatment complexity, illness appraisal, coping, and mood disturbance in patients with advanced-stage cancer.
. DESIGN: Cross-sectional study.
. SETTING: Smilow Cancer Hospital at Yale New Haven in Connecticut, an outpatient comprehensive cancer center.
. SAMPLE: A convenience sample of 121 adult patients with stages III-IV cancer undergoing active chemotherapy...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28632246/declines-noted-in-cognitive-processes-and-association-with-achievement-among-children-with-leukemia
#3
Kathleen C Insel, Marilyn J Hockenberry, Lynette L Harris, Kari M Koerner, Zhenqiang Lu, Kristin B Adkins, Olga A Taylor, Patricia M Gundy, Ida M Moore
PURPOSE/OBJECTIVES: To assess change in specific cognitive processes during treatment with chemotherapy only among children with acute lymphoblastic leukemia (ALL). 
. DESIGN: A prospective, repeated measures design.
. SETTING: Pediatric oncology treatment centers at Banner-University Medical Center Tucson/Banner Children's-Diamond Medical Center (University of Arizona) and Texas Children's Cancer and Hematology centers (Baylor College of Medicine) in Houston...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28627275/the-effects-of-exercise-on-patient-reported-outcomes-and-performance-based-physical-function-in-adults-with-acute-leukemia-undergoing-induction-therapy
#4
Ashley Leak Bryant, Allison M Deal, Claudio L Battaglini, Brett Phillips, Mackenzi Pergolotti, Erin Coffman, Matthew C Foster, William A Wood, Charlotte Bailey, Anthony C Hackney, Deborah K Mayer, Hyman B Muss, Bryce B Reeve
INTRODUCTION: Fatigue is a distressing symptom for adults with acute leukemia, often impeding their ability to exercise. OBJECTIVES: 1) Examine effects of a 4-week mixed-modality supervised exercise program (4 times a week, twice a day) on fatigue in adults with acute leukemia undergoing induction chemotherapy. 2) Evaluate effects of exercise program on cognition, anxiety, depression, and sleep disturbance. 3) Evaluate effect of intervention on adherence to exercise...
March 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28596484/chemotherapy-induced-changes-of-cerebral-activity-in-resting-state-functional-magnetic-resonance-imaging-and-cerebral-white-matter-in-diffusion-tensor-imaging
#5
Caiqin Mo, Hailong Lin, Fangmeng Fu, Lin Lin, Jie Zhang, Meng Huang, Chuan Wang, Yunjing Xue, Qing Duan, Weiwen Lin, Xiangjin Chen
While chemotherapy related cognitive disorder has been described in many studies, but we still lack relatively reliable and objective diagnostic tools, and there are few similar studies in Asian patients. We recruited Asian breast cancer patients to perform a cohort study to uncover chemotherapy related cognitive disorder by using resting-state functioning magnetic resonance imaging (RS-fMRI) and magnetic resonance diffusion tensor imaging (DTI) combined with neuropsychologic assessments. This is the first prospective study which combines RS-fMRI and DTI to detect chemotherapy related cognitive disorder...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28591103/treatment-of-acute-lymphoblastic-leukemia-in-older-adults-now-and-the-future
#6
Musa Yilmaz, Hagop Kantarjian, Elias Jabbour
Acute lymphoblastic leukemia (ALL) is an uncommon disease with poor outcomes in older patients. Although intensive chemotherapy can induce complete responses in older patients, the mortality rate is unacceptably high. The 5-year survival rate for patients achieving a remission ranges from 17% to 23%. ALL is usually more aggressive in older patients, and these patients' reduced functional capacity renders them less able to tolerate treatment. The need for less-intensive, more-efficient treatment modalities in this population of frail and high-risk patients is evident...
April 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28545980/altered-brain-function-in-new-onset-childhood-acute-lymphoblastic-leukemia-before-chemotherapy-a-resting-state-fmri-study
#7
Zhanqi Hu, Dongfang Zou, Huirong Mai, Xiuli Yuan, Lihong Wang, Yue Li, Jianxiang Liao, Liwei Liu, Guosheng Liu, Hongwu Zeng, Feiqiu Wen
OBJECTIVE: Cognitive impairments had been reported in childhood acute lymphoblastic leukemia, what caused the impairments needed to be demonstrated, chemotherapy-related or the disease itself. The primary aim of this exploratory investigation was to determine if there were changes in brain function of children with acute lymphoblastic leukemia before chemotherapy. METHODS: In this study, we advanced a measure named regional homogeneity to evaluate the resting-state brain activities, intelligence quotient test was performed at same time...
May 22, 2017: Brain & Development
https://www.readbyqxmd.com/read/28541578/disrupted-development-and-integrity-of-frontal-white-matter-in-patients-treated-for-pediatric-medulloblastoma
#8
John O Glass, Robert J Ogg, Jung W Hyun, Julie H Harreld, Jane E Schreiber, Yimei Li, Amar J Gajjar, Wilburn E Reddick
Background.: Treatment of pediatric medulloblastoma is associated with known neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal white matter (WM). Methods.: Longitudinal MRI examinations were collected from baseline (after surgery but before therapy) to 36 months in 146 patients and at 3 time points in 72 controls. Regional analyses of frontal WM volume and diffusion tensor imaging metrics were performed and verified with tract-based spatial statistics...
May 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28528421/end-of-life-care-for-glioblastoma-patients-at-a-large-academic-cancer-center
#9
Kamini E Kuchinad, Roy Strowd, Anne Evans, W Anthony Riley, Thomas J Smith
Glioblastoma (GBM) is a universally fatal disease, complicated by significant cognitive and physical disabilities, inherent to the disease course. The purpose of this study was to retrospectively analyze end-of-life care for GBM patients at an academic center and compare utilization of these services to national quality of care guidelines, with the goal of identifying opportunities to improve end-of-life care. Single center retrospective cohort study of GBM patients at Johns Hopkins Hospital (JHH) between 2009 and 2014, using electronic medical records and hospice records...
May 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28521365/cognitive-dysfunction-in-cancer-patients-likely-not-all-due-to-chemotherapy
#10
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521364/chemotherapy-and-post-traumatic-stress-in-the-causation-of-cognitive-dysfunction-in-breast-cancer-patients
#11
Kerstin Hermelink, Markus Bühner, Philipp Sckopke, Franziska Neufeld, Judith Kaste, Varinka Voigt, Karin Münzel, Rachel Wuerstlein, Nina Ditsch, Karin Hellerhoff, Dorothea Rjosk-Dendorfer, Michael Braun, Franz Edler von Koch, Kristin Härtl, Stephan Hasmüller, Ingo Bauerfeind, Gerlinde Debus, Peter Herschbach, Sven Mahner, Nadia Harbeck
Background: Cancer-related cognitive dysfunction has mostly been attributed to chemotherapy; this explanation, however, fails to account for cognitive dysfunction observed in chemotherapy-naïve patients. In a controlled, longitudinal, multisite study, we tested the hypothesis that cognitive function in breast cancer patients is affected by cancer-related post-traumatic stress. Methods: Newly diagnosed breast cancer patients and healthy control subjects, age 65 or younger, underwent three assessments within one year, including paper-and-pencil and computerized neuropsychological tests, clinical diagnostics of post-traumatic stress disorder (PTSD), and self-reported cognitive function...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28512046/risk-factors-for-preoperative-seizures-and-loss-of-seizure-control-in-patients-undergoing-surgery-for-metastatic-brain-tumors
#12
Adela Wu, Jon D Weingart, Gary L Gallia, Michael Lim, Henry Brem, Chetan Bettegowda, Kaisorn L Chaichana
OBJECTIVE: Metastatic brain tumors are the most common brain tumors in adults. Patients with metastatic brain tumors have poor prognoses with median survival of 6-12 months. Seizures are a major presenting symptom and cause of morbidity and mortality. Risk factors for the onset of preoperative seizures and postoperative seizure control are examined. METHODS: Adult patients who underwent resection of one or more brain metastases at a single institution between 1998 and 2011 were retrospectively reviewed...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28495470/cognitive-effects-of-chemotherapy-and-cancer-related-treatments-in-older-adults
#13
REVIEW
Jennifer N Vega, Julie Dumas, Paul A Newhouse
Advances in cancer treatment are producing a growing number of cancer survivors; therefore, issues surrounding quality of life during and following cancer treatment have become increasingly important. Chemotherapy-related cognitive impairment (CRCI) is a problem that is commonly reported following the administration of chemotherapy treatment in patients with cancer. Research suggests that CRCI can persist for months to years after completing treatment, which has implications for the trajectory of normal and pathologic cognitive aging for the growing number of long-term cancer survivors...
April 6, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28487465/geriatric-assessment-predicts-survival-and-competing-mortality-in-elderly-patients-with-early-colorectal-cancer-can-it-help-in-adjuvant-therapy-decision-making
#14
Maite Antonio, Juana Saldaña, Alberto Carmona-Bayonas, Valentín Navarro, Cristian Tebé, Marga Nadal, Francesc Formiga, Ramon Salazar, Josep Maria Borràs
BACKGROUND: The challenge when selecting elderly patients with colorectal cancer (CRC) for adjuvant therapy is to estimate the likelihood that death from other causes will preclude cancer events from occurring. The aim of this paper is to evaluate whether comprehensive geriatric assessment (CGA) can predict survival and cancer-specific mortality in elderly CRC patients candidates for adjuvant therapy. MATERIAL AND METHODS: One hundred ninety-five consecutive patients aged ≥75 with high-risk stage II and stage III CRC were prospectively included from May 2008 to May 2015...
May 9, 2017: Oncologist
https://www.readbyqxmd.com/read/28487078/treatment-of-chronic-lymphocytic-leukemia-in-older-adults
#15
REVIEW
Rachael B Rowswell-Turner, Paul M Barr
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and it typically afflicts older adults, with a median age at diagnosis of 71. Traditional treatments for CLL have included chemotherapy, which can often be difficult for older patients to tolerate. Given the variability in fitness, cognition and comorbidities amongst older patients, a geriatric evaluation should be considered prior to commencement of cytotoxic therapy. More recently, novel oral agents are proving to be both safe and effective in this population, redefining the field of CLL therapy...
May 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28481816/changes-in-and-determinants-of-quality-of-life-in-patients-with-advanced-non-small-cell-lung-cancer-undergoing-initial-chemotherapy
#16
Yu-Lee Dai, Cheng-Ta Yang, Kang-Hua Chen, Siew-Tzuh Tang
BACKGROUND: Few studies have evaluated completely the changes in quality of life (QOL) that occur from pretreatment through the first four consecutive cycles of chemotherapy or determined its determinants in patients with advanced non-small-cell lung cancer (NSCLC). PURPOSE: The aim of this study was to explore the changes to and determinants of QOL in patients with advanced NSCLC under initial chemotherapy from pretreatment through Cycle 4 of chemotherapy. METHODS: The QOL of 139 patients with advanced NSCLC was assessed from prechemotherapy through Cycle 4 of chemotherapy...
June 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28472802/evaluation-of-the-effectiveness-of-a-multimodal-complementary-medicine-program-for-improving-the-quality-of-life-of-cancer-patients-during-adjuvant-radiotherapy-and-or-chemotherapy-or-outpatient-aftercare
#17
Martin Domnick, Manju Domnick, Karl-Rüdiger Wiebelitz, André-Michael Beer
OBJECTIVES: Evidence for complementary therapies as important strategies to relieve cancer treatment-associated symptoms is increasing. Mostly, these complementary therapies start at the end of adjuvant treatments, resulting in a long delay until the well-being of patients is addressed. Further, long distances between the rehabilitation center and the patients' residence hinder patients' compliance. METHODS: The multimodal outpatient LOTUS Care Cure Project (LCCP) was tested in a randomized controlled trial including patients of various cancer entities and stages while on adjuvant chemotherapy and/or radiotherapy or outpatient aftercare...
May 5, 2017: Oncology
https://www.readbyqxmd.com/read/28466438/a-mechanistic-cohort-study-evaluating-cognitive-impairment-in-women-treated-for-breast-cancer
#18
Janette L Vardy, Myrle M Stouten-Kemperman, Gregory Pond, Christopher M Booth, Sean B Rourke, Haryana M Dhillon, Anna Dodd, Adrian Crawley, Ian F Tannock
Some women report cognitive impairment after adjuvant chemotherapy (CTh) for breast cancer. Here we explore cognitive function, and underlying mechanisms with blood tests and functional magnetic resonance imaging (fMRI). Women treated for early breast cancer were recruited to three groups based on self-reported cognitive symptoms (CS) using FACT-Cog scores. CTh + CS+ (n = 44) had received chemotherapy and self-reported cognitive symptoms; CTh + CS- (n = 52) had chemotherapy but did not report cognitive problems; CTh- (n = 30) had not received chemotherapy...
May 2, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28452903/zonisamide-in-brain-tumor-related-epilepsy-an-observational-pilot-study
#19
Marta Maschio, Loredana Dinapoli, Alessia Zarabla, Andrea Maialetti, Diana Giannarelli, Alessandra Fabi, Antonello Vidiri, Tonino Cantelmi
OBJECTIVES: Epilepsy heavily affects the quality of life (QoL) of patients with brain tumor because in addition to taking treatments for the oncological illness, patients are required to live with the long-term taking of antiepileptic drugs (AEDs). The AEDs' adverse effects are common in these patients and can negatively influence their perceptions of their QoL.We conducted an observational pilot study in patients with brain tumor-related epilepsy to verify efficacy, tolerability, and impact on QoL and global neurocognitive performances of zonisamide (ZNS) in add-on...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28440532/the-assessment-of-cancer-related-fatigue-syndrome-in-patients-with-lung-cancer-during-palliative-chemotherapy
#20
Andrzej Nowicki, Joanna Piekarska, Ewa Farbicka
INTRODUCTION: Cancer-related fatigue is one of the most common problems of patients with lung cancer. The assessment of cancer- -related fatigue is therefore a significant medical problem in patients during treatment with palliative chemotherapy. MATERIAL AND METHODS: The study included 100 patients during palliative chemotherapy because of lung cancer. The study was conducted in the Department of Pulmonary Diseases and Treatment of Lung Cancer in the Kuyavian and Pomeranian Centre of Pulmonology in Bydgoszcz, in the period from February to June 2016...
2017: Advances in Respiratory Medicine
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