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chemotherapy and cognition

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https://www.readbyqxmd.com/read/29775693/comparison-of-coping-psychological-distress-and-level-of-functioning-in-patients-with-gastric-and-colorectal-cancer-prior-to-adjuvant-chemotherapy
#1
Caterina Calderón, Paula Jimenez-Fonseca, Carlos Jara, Raquel Hernández, Eva Martínez de Castro, Sonal Varma, Ismael Ghanem, Alberto Carmona-Bayonas
CONTEXT-: Patients with gastrointestinal cancers are at high risk for functional problems that are generally accompanied by a decline in their overall status and intense psychological distress. OBJECTIVES: This study compares the level of functioning in individuals with gastric cancer (GC) and colorectal cancer (CRC) and analyzes whether improved functioning can be explained by patients' psychological status and coping strategies. METHODS: Prospective, transversal, multicenter study in patients with non-metastatic GC and CRC prior to initiating adjuvant chemotherapy...
May 15, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#2
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29767912/gender-differences-in-the-perception-of-quality-of-life-of-patients-with-colorectal-cancer
#3
Isadora Trinquinato, Rodrigo Marques da Silva, Sonia Betzabeth Ticona Benavente, Camila Cristine Antonietti, Ana Lúcia Siqueira Costa Calache
OBJECTIVES: To identify the gender differences in assessing quality of life of patients undergoing chemotherapy treatment for colorectal cancer. METHODS: This is a cross-sectional investigation conducted with 144 patients (72 men and 72 women) undergoing chemotherapy treatment in a southeastern Brazilian hospital. Data were gathered trough a sociodemographic and clinical information form and the Health-related Quality of Life instrument from the European Organization for Research and Treatment of Cancer...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29759914/symptom-cluster-of-emotional-distress-fatigue-and-cognitive-difficulties-among-young-and-older-breast-cancer-survivors-the-mediating-role-of-subjective-stress
#4
Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta Fried
OBJECTIVES: To examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster. MATERIALS AND METHODS: Participants were 170 BCS, stages I-III, 1-12 months post-chemotherapy, filled-out the Fatigue, Emotional Control, Meaning-focused Coping, Emotional Distress and the Cognitive Difficulties Questionnaires...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29759139/identifying-cytokine-predictors-of-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-post-chemotherapy-using-machine-learning
#5
Ashley M Henneghan, Oxana Palesh, Michelle Harrison, Shelli R Kesler
INTRODUCTION: The purpose of this study is to explore 13 cytokine predictors of chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCS) 6 months to 10 years after chemotherapy completion using a multivariate, non-parametric approach. METHODS: Cross sectional data collection included completion of a survey, cognitive testing, and non-fasting blood from 66 participants. Data were analyzed using random forest regression to identify the most significant predictors for each of the cognitive test scores...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29755682/evaluation-of-the-impact-of-s-adenosylmethionine-dependent-methyltransferase-inhibitor-3-deazaneplanocin-a-on-tissue-injury-and-cognitive-function-in-mice
#6
Eva Lhuissier, Juliette Aury-Landas, Valentine Bouet, Céline Bazille, Yohann Repesse, Thomas Freret, Karim Boumédiene, Catherine Baugé
Cancer patients display cognitive impairment due, at least partly, to the treatments. Additionally, chemotherapeutic treatments can lead to organ injury, limiting their use, and are likely to have negative impacts on patients' quality of life. The aim of this study was to investigate the toxicity of 3-Deazaneplanocin A (DZNep) on several tissues and organs, as well as on cognitive functions. DZNep is an inhibitor of S-adenosylmethionine-dependent methyltransferase (in particular of the histone methyltransferase EZH2) which showed antitumoral functions in preclinical trials but whose effects on behavior and on organs (side effects) are not known...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29746441/cognitive-profile-of-children-with-intracranial-germ-cell-tumor-according-to-tumor-location
#7
Virginie Coutinho, Georges Dellatolas, Clemence Castaignede-Lalande, Audrey Longaud-Vales, Virginie Kieffer, Lea Guerrini-Rousseau, Jacques Grill, Dominique Valteau-Couanet, Christelle Dufour
PURPOSE: The purpose of this study was to evaluate the long-term cognitive sequelae and to describe the neuropsychological profile of patients with intracranial germ cell tumors according to tumor location (pineal or suprasellar site). PATIENTS AND METHODS: Forty-five children treated at Gustave Roussy between 1991 and 2010 were assessed with neuropsychological tests to measure IQ, memory, visuospatial, motor, and executive skills at a mean delay of 4.2 years after diagnosis...
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29744963/chemotherapy-associated-cognitive-impairments-in-korean-cancer-patients-risk-factors-and-functional-outcome
#8
Hee-Ju Kim, Andrea M Barsevick, Alexandre Chan, Jung-Woo Chae
OBJECTIVE: To identify those experiencing significant self-reported cognitive decline over 2 time points during chemotherapy, examine the risk factors for cognitive decline, and examine differences between those with and without significant decline in functional limitations. METHODS: This secondary analysis used data from 163 cancer patients, collected from a Korean University hospital. Significant decline was determined by 15% or more reduction from baseline in the Functional Assessment of Cancer Therapy-Cognitive Function...
May 10, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29742721/coexistence-of-lambert-eaton-myasthenic-syndrome-and-autoimmune-encephalitis-with-anti-crmp5-cv2-and-anti-gabab-receptor-antibodies-in-small-cell-lung-cancer-a-case-report
#9
Hongfang Li, Aimei Zhang, Yanlei Hao, Hongzhi Guan, Zhanyun Lv
RATIONALE: Autoimmune encephalitis and Lambert-Eaton myasthenic syndrome are classic paraneoplastic neurological conditions common in patients with small cell lung cancer. PATIENT CONCERNS: The patient complained of tiredness, fluctuating recent memory loss, and inability to find his home. His family members reported a change in character, irritability, and paranoia. One month later, the patient had 1 grand mal seizure lasting 5 minutes. DIAGNOSIS: The patient was diagnosed with limbic encephalitis combined with Lambert-Eaton myasthenic syndrome...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29735975/efficacy-of-acupuncture-therapy-for-chemotherapy-related-cognitive-impairment-in-breast-cancer-patients
#10
Taishan Tong, Chunqin Pei, Jun Chen, Qing Lv, Fuquan Zhang, Zaohuo Cheng
BACKGROUND Chemotherapy can cause adverse effects such as chemotherapy-related cognitive impairment (CRCI). In this prospective study, the efficacy of traditional Chinese medicine acupuncture therapy in relieving CRCI and its impact on serum brain-derived neurotrophic factor (BDNF) are evaluated. MATERIAL AND METHODS Eighty patients were randomly divided into a treatment group and a control group with 40 patients in each group. The treatment group was treated at the following acupuncture points: Baihui (DU20), Sishencong (EX-HN1), Shenting (DU24), Zusanli (ST36), Taixi (K13), Dazhong (K14), and Juegu (GB39)...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29734752/mitoxantrone-is-more-toxic-than-doxorubicin-in-sh-sy5y-human-cells-a-chemobrain-in-vitro-study
#11
Daniela Almeida, Rita Pinho, Verónica Correia, Jorge Soares, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela, Vera Marisa Costa
The potential neurotoxic effects of anticancer drugs, like doxorubicin (DOX) and mitoxantrone (MTX; also used in multiple sclerosis), are presently important reasons for concern, following epidemiological data indicating that cancer survivors submitted to chemotherapy may suffer cognitive deficits. We evaluated the in vitro neurotoxicity of two commonly used chemotherapeutic drugs, DOX and MTX, and study their underlying mechanisms in the SH-SY5Y human neuronal cell model. Undifferentiated human SH-SY5Y cells were exposed to DOX or MTX (0...
May 5, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29734461/an-n-of-1-feasibility-study-of-homeopathic-treatment-for-fatigue-in-patients-receiving-chemotherapy
#12
David Brulé, Jeffrey Balon, Linlu Zhao, Dugald Seely
BACKGROUND:  Cancer-related fatigue has been described as a subjective feeling of physical, emotional, and/or cognitive tiredness. Homeopathy has been widely used to treat side effects of chemotherapy. The n-of-1 design is a single-patient trial method to study a clinical condition that is either short lived and reversible or is chronic and stable. The n-of-1 design requires a washout/reset period. The feasibility of performing an n-of-1 study in homeopathy has not previously been tested...
May 7, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29728959/systematic-review-of-self-reported-cognitive-function-in-cancer-patients-following-chemotherapy-treatment
#13
REVIEW
Victoria J Bray, Haryana M Dhillon, Janette L Vardy
PURPOSE: Cognitive symptoms are common in cancer patients, with up to 70% reporting cognitive symptoms following chemotherapy. These symptoms can have a major impact on how an individual functions in all aspects of their lives. This review evaluates self-reported cognitive function and its associations with neuropsychological tests and patient-reported outcomes in adult cancer patients who received chemotherapy treatment for a solid cancer. METHODS: A search of multiple databases (Medline, Ovid at Nursing, PsycINFO, Allied and Complementary Medicine) from 1936 to 2017 was conducted, identifying 1563 unique articles, of which 101 met inclusion criteria...
May 4, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29720224/assessing-brain-volume-changes-in-older-women-with-breast-cancer-receiving-adjuvant-chemotherapy-a-brain-magnetic-resonance-imaging-pilot-study
#14
Bihong T Chen, Sean K Sethi, Taihao Jin, Sunita K Patel, Ningrong Ye, Can-Lan Sun, Russell C Rockne, E Mark Haacke, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, George Somlo, Daneng Li, Richard Yang, Heidi Tan, Vani Katheria, Rachel Morrison, Arti Hurria
BACKGROUND: Cognitive decline is among the most feared treatment-related outcomes of older adults with cancer. The majority of older patients with breast cancer self-report cognitive problems during and after chemotherapy. Prior neuroimaging research has been performed mostly in younger patients with cancer. The purpose of this study was to evaluate longitudinal changes in brain volumes and cognition in older women with breast cancer receiving adjuvant chemotherapy. METHODS: Women aged ≥ 60 years with stage I-III breast cancer receiving adjuvant chemotherapy and age-matched and sex-matched healthy controls were enrolled...
May 2, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29708996/mild-cognitive-dysfunction-of-caregivers-and-its-association-with-care-recipients-end-of-life-plans-and-preferences
#15
Keiko Kurita, Mark S Lachs, Ronald D Adelman, Eugenia L Siegler, M Cary Reid, Holly G Prigerson
Little is known about the association between cognitive dysfunction among informal caregivers and patients' plans and preferences for patients' end of life care. We report on the frequency of cognitive dysfunction among both patients and caregivers and examine associations between caregivers' cognitive screening scores and end of life plans and preferences of patients with advanced cancer. The current sample was derived from a National Cancer Institute- and National Institute of Mental Health-funded study of patients with distant metastasis who had disease progression on at least first-line chemotherapy, and their informal caregivers (n = 550 pairs)...
2018: PloS One
https://www.readbyqxmd.com/read/29706424/patient-and-tumor-related-predictors-of-chemotherapy-intolerance-in-older-patients-with-cancer-a-systematic-review
#16
REVIEW
Doris L van Abbema, Marjan van den Akker, Maryska L Janssen-Heijnen, Franchette van den Berkmortel, Ann Hoeben, Judith de Vos-Geelen, Frank Buntinx, Jos Kleijnen, Vivianne C G Tjan-Heijnen
OBJECTIVE: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemotherapy intolerance in cancer patients aged 65 years or older. METHODS: We included observational studies that reported data on possible predictors of chemotherapy intolerance in older patients with cancer...
April 26, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29705024/impact-of-adjuvant-anthracycline-based-and-taxane-based-chemotherapy-on-plasma-vegf-levels-and-cognitive-function-in-breast-cancer-patients-a-longitudinal-study
#17
Terence Ng, Xiang Yun Phey, Hui Ling Yeo, Maung Shwe, Yan Xiang Gan, Raymond Ng, Han Kiat Ho, Alexandre Chan
BACKGROUND: Vascular endothelial growth factor (VEGF) has been shown to induce neurogenesis in the brain and yield neuroprotective effects. It is hypothesized that chemotherapy reduces circulating VEGF levels and leads to cognitive decline among patients. This multicenter longitudinal study aimed to evaluate the impact of chemotherapy on VEGF levels and the association between VEGF levels and cognitive function. PATIENTS AND METHODS: A total of 145 early-stage breast cancer patients were recruited and assessed before chemotherapy (T1), during chemotherapy (T2), and at the end of chemotherapy (T3)...
April 6, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29683228/relationships-between-self-reported-sleep-quality-components-and-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-following-chemotherapy
#18
Ashley M Henneghan, Patricia Carter, Alexa Stuifbergan, Brennan Parmelee, Shelli Kesler
OBJECTIVE: Links have been made between aspects of sleep quality and cognitive function in breast cancer survivors (BCS), but findings are heterogeneous. The objective of this study is to examine relationships between specific sleep quality components (latency, duration, efficiency, daytime sleepiness, sleep disturbance, use of sleep aids) and cognitive impairment (performance and perceived), and determine which sleep quality components are the most significant contributors to cognitive impairments in BCS 6 months to 10 years post chemotherapy...
April 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#19
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29649913/effects-of-an-exercise-intervention-on-cancer-related-fatigue-and-its-relationship-to-markers-of-oxidative-stress
#20
Chris P Repka, Reid Hayward
BACKGROUND: Although the underlying mechanisms of cancer-related fatigue (CRF) are not fully characterized, treatment-associated oxidative stress may play a role. The purpose of this study was to determine the effect of an exercise intervention on the relationship between CRF and oxidative stress. METHODS: Upon cessation of radiation or chemotherapy, 8 cancer patients participated in a 10-week exercise intervention (EX), while 7 continued standard care (CON). Blood draws and fatigue questionnaires were administered to cancer patients before and after the intervention as well as to 7 age-matched individuals with no cancer history...
April 1, 2018: Integrative Cancer Therapies
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