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chemotherapy and cognition

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https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#1
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29139007/adding-high-intensity-interval-training-to-conventional-training-modalities-optimizing-health-related-outcomes-during-chemotherapy-for-breast-cancer-the-optitrain-randomized-controlled-trial
#2
Sara Mijwel, Malin Backman, Kate A Bolam, Anna Jervaeus, Carl Johan Sundberg, Sara Margolin, Maria Browall, Helene Rundqvist, Yvonne Wengström
PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy...
November 14, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29136185/cognitive-dysfunction-among-newly-diagnosed-older-patients-with-hematological-malignancy-frequency-clinical-indicators-and-predictors
#3
Sayo Aiki, Toru Okuyama, Koji Sugano, Yosuke Kubota, Fuminobu Imai, Masahiro Nishioka, Yoshinori Ito, Shinsuke Iida, Hirokazu Komatsu, Takashi Ishida, Shigeru Kusumoto, Tatsuo Akechi
Background: Medical staff often overlook or underestimate the presence or severity of cognitive dysfunction. The purpose of this study was to clarify the frequency, clinical indicators and predictors of cognitive dysfunction among newly diagnosed older patients with hematologic malignancy receiving first-line chemotherapy. Methods: Patients aged 65 years or over with a primary diagnosis of malignant lymphoma or multiple myeloma were consecutively recruited. Cognitive dysfunction was evaluated using the Mini-Mental State Examination (MMSE) twice: before starting chemotherapy (T1) and 1 month later (T2)...
November 10, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29128118/associations-between-inflammatory-markers-and-cognitive-function-in-breast-cancer-patients-receiving-chemotherapy
#4
AnnaLynn M Williams, Raven Shah, Michelle Shayne, Alissa J Huston, Marcia Krebs, Nicole Murray, Bryan D Thompson, Kassandra Doyle, Jenna Korotkin, Edwin van Wijngaarden, Sharon Hyland, Jan A Moynihan, Deborah A Cory-Slechta, Michelle C Janelsins
BACKGROUND: Cancer-related cognitive impairment (CRCI) is often related to chemotherapy. Increased chronic inflammation is believed to play a key role in the development of CRCI related to chemotherapy but studies assessing this hypothesis specifically in patients receiving chemotherapy are rare. METHODS: We assessed several cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in twenty-two breast cancer patients currently receiving chemotherapy...
October 18, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29123357/complementary-therapies-for-symptom-management-in-cancer-patients
#5
Aanchal Satija, Sushma Bhatnagar
Cancer patients are often poly-symptomatic which distressingly affects their quality of lives (QOLs). Alhough, conventional management provides adequate symptom control, yet is coupled with some limitations. Complementary therapies (CTs) have shown beneficial effects in cancer patients for symptomatic relief. The aim of this article is to provide evidence-based review of commonly used CTs for symptom management in cancer care. Hypnosis has promising evidence to be used for managing symptoms such as pain, chemotherapy-induced nausea/vomiting, distress, fatigue, and hot flashes...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29116555/modifiable-correlates-of-perceived-cognitive-function-in-breast-cancer-survivors-up-to-10%C3%A2-years-after-chemotherapy-completion
#6
Ashley Henneghan, Alexa Stuifbergen, Heather Becker, Shelli Kesler, Elisabeth King
BACKGROUND: Cognitive changes following breast cancer treatment are likely multifactorial and have been linked to emotional factors, biophysiological factors, and fatigue, among others. Little is known about the contributions of modifiable factors such as stress, loneliness, and sleep quality. The purpose of this study was to explore the direct and indirect effects of perceived stress, loneliness, and sleep quality on perceived cognitive function (PCF) in breast cancer survivors (BCS) after chemotherapy completion...
November 7, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29115823/an-overview-of-the-clinical-uses-pharmacology-and-safety-of-modafinil
#7
Eric Murillo-Rodriguez, André Barciela Veras, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado
Modafinil (MOD) is a drug used for the management of excessive daytime sleepiness observed in several sleep disturbances such as shift work sleep disorder, obstructive sleep apnea, restless leg syndrome and narcolepsy. Additionally, a wide scope of medical uses of MOD have been described such as fatigue in subjects with depression as well as patients under chemotherapy. Moreover, there also appear to be a cognitive enhancer drug. In contrast, recent reports have indicated the risk of developing addiction to MOD...
November 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29113931/neurobiological-mechanisms-of-chemotherapy-induced-cognitive-impairment-in-a-transgenic-model-of-breast-cancer
#8
Gordon Winocur, Hal Berman, Mary Nguyen, Malcolm A Binns, Mark Henkelman, Matthijs van Eede, Micheline Piquette-Miller, Melanie J Sekeres, J Martin Wojtowicz, Johnson Yu, Haibo Zhang, Ian F Tannock
Animal studies have reinforced clinical reports of cognitive impairment in cancer survivors following chemotherapy but, until now, all pre-clinical research in this area has been conducted on normal rodents. The present study investigated the effects of chemotherapy on cognition and underlying biological mechanisms in the FVB/N-Tg (MMTV-neu) 202 Mul/J mouse, a well-characterized transgenic model of breast cancer that has similarities to the tumorigenesis which occurs in humans. Tumor-bearing and control mice received three weekly injections of a combination of methotrexate + 5-fluorouracil, or an equal volume of saline...
November 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/29113386/chemotherapy-induced-changes-of-cerebral-activity-in-resting-state-functional-magnetic-resonance-imaging-and-cerebral-white-matter-in-diffusion-tensor-imaging
#9
Caiqin Mo, Hailong Lin, Fangmeng Fu, Lin Lin, Jie Zhang, Meng Huang, Chuan Wang, Yunjing Xue, Qing Duan, Weiwen Lin, Xiangjin Chen
While chemotherapy related cognitive disorder has been described in many studies, but we still lack relatively reliable and objective diagnostic tools, and there are few similar studies in Asian patients. We recruited Asian breast cancer patients to perform a cohort study to uncover chemotherapy related cognitive disorder by using resting-state functioning magnetic resonance imaging (RS-fMRI) and magnetic resonance diffusion tensor imaging (DTI) combined with neuropsychologic assessments. This is the first prospective study which combines RS-fMRI and DTI to detect chemotherapy related cognitive disorder...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29092778/cognitive-impairment-in-breast-cancer-survivors-treated-with-chemotherapy-depends-on-control-group-type-and-cognitive-domains-assessed-a-multilevel-meta-analysis
#10
REVIEW
Lori J Bernstein, Graham A McCreath, Zahra Komeylian, Jill B Rich
Women with breast cancer can experience persisting cognitive deficits post treatment. We conducted a multilevel meta-analysis of cognitive function in survivors treated with chemotherapy (Ch+) to estimate the magnitude of cognitive impairment relative to healthy (HC) and chemo-negative (Ch-) controls. Seventy-two studies published up to October 2016 involving 2939 Ch+ yielded 1594 effect sizes. Ch+ demonstrated overall cognitive impairment in comparison with HC but not with Ch-. Relative to HC, Ch+ showed impairment in attention/concentration, processing speed, language, immediate recall, delayed recall, and executive function...
October 29, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29091520/chemotherapy-related-cognitive-impairment-342
#11
Katharine K Brewster, Daniel Shalev, Jon A Levenson
No abstract text is available yet for this article.
November 1, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29090030/cancer-related-fatigue-in-breast-cancer-survivors-in-correlation-to-demographic-factors
#12
Fatemeh Moghaddam Tabrizi, Saeedeh Alizadeh
BACKGROUND: Fatigue is one of the most frequent symptoms in cancer patients. However, its exact causes are still unknown, and this circumstance makes it complicated to encounter the problem. OBJECTIVE: The current research was carried out to investigate factors associated with fatigue in cancer patients without other diseases. MATERIALS AND METHODS: The research was conducted in 2013. A group of 150 randomly selected breast cancer patients who had successful surgical treatment and attending in oncology ward to receive chemotherapy and radiotherapy...
June 2017: Mædica
https://www.readbyqxmd.com/read/29082588/determinants-of-physical-affective-and-cognitive-fatigue-during-breast-cancer-therapy-and-12-months-follow-up
#13
Martina E Schmidt, Joachim Wiskemann, Andreas Schneeweiss, Karin Potthoff, Cornelia M Ulrich, Karen Steindorf
Fatigue is common in cancer survivors but often insufficiently treated. Due to its complexity a one-size-fits-all treatment seems not appropriate. To gain more information on influencing factors and sub-dimensions of fatigue we investigated potential determinants and correlates of physical, affective, and cognitive fatigue in breast cancer survivors during and after adjuvant therapy. Within the follow-up of two randomized controlled trials physical, affective, and cognitive fatigue were repeatedly assessed during and up to 12 months after cancer therapy with the 20-item Fatigue Assessment Questionnaire in 255 breast cancer survivors...
October 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29080061/perceived-cognitive-impairment-in-people-with-colorectal-cancer-who-do-and-do-not-receive-chemotherapy
#14
Haryana M Dhillon, Ian F Tannock, Gregory R Pond, Corrinne Renton, Sean B Rourke, Janette L Vardy
PURPOSE: Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. METHODS: Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months...
October 27, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29076421/seizures-and-anticonvulsants-in-brain-tumours-frequency-mechanisms-and-anti-epileptic-management
#15
Charles Vecht, Louis Royer-Perron, Caroline Houillier, Gilles Huberfeld
In cancer, epilepsy can be the manifestation of a primary brain tumour, metastatic disease, vascular or surgical complications, opportunistic infection or secondary to anti-tumour therapy. Seizures are frequently the first symptom of a brain tumour. The epilepsy is related to elevated extracellular glutamate stimulating NMDA- and AMPA-receptors and to the formation of D-2HG which resembles glutamate in IDH1 mutated gliomas. Epilepsy as presenting sign is associated with a longer survival in low- and high- grade gliomas, particularly with the IDH1 mutation...
October 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29073552/chemotherapy-induced-cognitive-impairments-white-matter-pathologies
#16
REVIEW
A Matsos, M Loomes, I Zhou, E Macmillan, I Sabel, E Rotziokos, W Beckwith, I N Johnston
Whilst chemotherapeutic agents show promising results in the amelioration of cancerous tumors, patients often experience cognitive disturbances associated with chemotherapy long after treatment has ceased. Research has suggested that the structural integrity of white matter fibres in the brain are susceptible to the harmful effects of chemotherapy. Post-chemotherapy, white matter tracts often display altered morphology with a reduction in glial cells such as oligodendrocytes. Demyelination, gliosis and leukoencephalopathy during or post chemotherapy is associated with changes in processing speed and IQ...
October 12, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29059209/neoadjuvant-chemotherapy-versus-primary-debulking-surgery-in-advanced-epithelial-ovarian-cancer-a-meta-analysis-of-peri-operative-outcome
#17
Lijuan Yang, Bo Zhang, Guangyang Xing, Jingran Du, Bin Yang, Qianqian Yuan, Yongxiu Yang
OBJECTIVE: To assess whether neoadjuvant chemotherapy (NACT) is superior to primary debulking surgery (PDS) with regard to optimal cytoreduction, peri-operative morbidity, mortality, and quality of life (QOL) in advanced epithelial ovarian cancer (EOC). METHODS: We searched the PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Registers of Clinical Trials for randomized controlled trials (RCTs) comparing NACT to PDS in women with Federation of International Gynaecologists and Obstetricians stage Ⅲ-Ⅳ EOC...
2017: PloS One
https://www.readbyqxmd.com/read/29055062/cognition-quality-of-life-and-symptom-clusters-in-breast-cancer-using-bayesian-networks-to-elucidate-complex-relationships
#18
Selene Xu, Wesley Thompson, Sonia Ancoli-Israel, Lianqi Liu, Barton Palmer, Loki Natarajan
OBJECTIVE: Breast cancer patients frequently complain of cognitive dysfunction during chemotherapy. Patients also report experiencing a cluster of sleep problems, fatigue and depressive symptoms during chemotherapy. We aimed to understand the complex dynamic interrelationships of depression, fatigue, and sleep to ultimately elucidate their role in cognitive performance and quality of life among breast cancer survivors undergoing chemotherapy treatment. METHODS: Our study sample comprised 74 newly diagnosed stage I-III breast cancer patients scheduled to receive chemotherapy, and followed them for one year...
October 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29054815/whole-brain-radiotherapy-or-autologous-stem-cell-transplantation-as-consolidation-strategies-after-high-dose-methotrexate-based-chemoimmunotherapy-in-patients-with-primary-cns-lymphoma-results-of-the-second-randomisation-of-the-international-extranodal-lymphoma
#19
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested...
October 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29052667/differences-in-coping-among-african-american-women-with-breast-cancer-and-triple-negative-breast-cancer
#20
Crystal C Watkins, Iye Kamara Kanu, Jill B Hamilton, Sharon L Kozachik, Fannie Gaston-Johansson
PURPOSE/OBJECTIVES: To determine differences in psychological distress, symptoms, coping capacity, and coping abilities among African American (AA) women with triple-negative breast cancer (TNBC) and non-TNBC and to explore differences in relationships among these variables.
. DESIGN: A prospective, descriptive, comparative, and correlational design.
. SETTING: Johns Hopkins Hospital in Baltimore, Maryland.
. SAMPLE: 30 AA women with breast cancer...
November 1, 2017: Oncology Nursing Forum
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