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https://www.readbyqxmd.com/read/29332186/assessment-of-oral-cancer-pain-anxiety-and-quality-of-life-of-oral-squamous-cell-carcinoma-patients-with-invasive-treatment-procedure
#1
Endang Sjamsudin, Tantry Maulina, Ahmad Cipta, Aulia Iskandarsyah, Andri Hardianto, Mantra Nandini, Alwin Kasim, Harmas Yazid Yusuf
PURPOSE: Depending on its stage on diagnosis, oral squamous cell carcinoma (OSCC) might cause excruciating pain and decreased quality of life. As for treatment, the treatment of OSCC might vary from chemotherapy to surgery. The objective of the current study was to assess the preoperative and postoperative oral cancer pain, anxiety, and quality of life of OSCC patients with invasive treatment procedure. METHODS: The current study was conducted by interviewing 21 (10 males; 11 females) patients who had been diagnosed with stage 3 and stage 4 OSCC and about to go through surgery at the inpatient ward of Surgical Oncology Department, Hasan Sadikin Hospital, Bandung, Indonesia...
January 13, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29299751/risk-factors-for-unplanned-discontinuation-of-scheduled-treatment-in-elderly-patients-with-castration-resistant-prostate-cancer-results-of-the-ibutu-study
#2
Friedemann Honecker, Ulrich Wedding, Gerd Kallischnigg, Axel Schroeder, Jörg Klier, Thomas Frangenheim, Lothar Weißbach
PURPOSE: To gain knowledge about the factors associated with discontinuation of scheduled treatment in elderly men with castration-resistant prostate cancer (CRPC). METHODS: Patients ≥ 70 years with CRPC starting a new line of treatment were included in a prospective cohort study. A geriatric assessment (CGA) was performed at baseline, including comorbidity, mobility, functional/mental/nutritional status, as well as depression. Furthermore, pain intensity, quality of life, ECOG-performance status, and physicians' and patients' perception of health were documented...
January 4, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29298488/engineered-cellular-uptake-and-controlled-drug-delivery-using-two-dimensional-nanoparticle-and-polymer-for-cancer-treatment
#3
Sudipta Senapati, Rashmi Shukla, Arun Kumar Mahanta, Dipak Rana, Pralay Maiti, Yamini B Tripathi
Two major problems in chemotherapy, poor bioavailability of hydrophobic anti-cancer drug and its adverse side effects causing nausea, are taken into accounts by developing sustained drug release vehicle along with enhanced bioavailability using two-dimensional layered double hydroxides (LDHs) with appropriate surface charge and its subsequent embedment in polymer matrix. A model hydrophobic anti-cancer drug, raloxifene hydrochloride (RH), is intercalated into a series of zinc iron LDHs with varying anion charge densities using ion exchange technique...
January 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29276837/effects-of-behavioral-activation-on-the-quality-of-life-and-emotional-state-of-lung-cancer-and-breast-cancer-patients-during-chemotherapy-treatment
#4
Concepción Fernández-Rodríguez, Erica Villoria-Fernández, Paula Fernández-García, Sonia González-Fernández, Marino Pérez-Álvarez
Research suggests that the progressive abandonment of activities in cancer patients are related to depression and worse quality of life. Behavioral activation (BA) encourages subjects to activate their sources of reinforcement and modify the avoidance responses. This study assesses the effectiveness of BA in improving quality of life and preventing emotional disorders during chemotherapy treatment. One sample of lung cancer patients and another of breast cancer patients were randomized into a BA experimental group (E...
December 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/29258975/public-perceptions-regarding-use-of-virtual-reality-in-health-care-a-social-media-content-analysis-using-facebook
#5
Michelle Sophie Keller, Hannah J Park, Maria Elena Cunningham, Joshua Eleazar Fouladian, Michelle Chen, Brennan Mason Ross Spiegel
BACKGROUND: Virtual reality (VR) technology provides an immersive environment that enables users to have modified experiences of reality. VR is increasingly used to manage patients with pain, disability, obesity, neurologic dysfunction, anxiety, and depression. However, public opinion regarding the use of VR in health care has not been explored. Understanding public opinion of VR is critical to ensuring effective implementation of this emerging technology. OBJECTIVE: This study aimed to examine public opinion about health care VR using social listening, a method that allows for the exploration of unfiltered views of topics discussed on social media and online forums...
December 19, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29258398/pilot-study-of-metabolomics-and-psychoneurological-symptoms-in-women-with-early-stage-breast-cancer
#6
Debra E Lyon, Angela Starkweather, Yingwei Yao, Timothy Garrett, Debra Lynch Kelly, Victoria Menzies, Paweł Dereziński, Susmita Datta, Sreelakshmy Kumar, Colleen Jackson-Cook
Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/29249789/-native-aortic-valve-endocarditis-caused-by-nocardia-asteroides-report-of-a-case
#7
Hiroshi Ishitoya, Eiki Sano, Rihito Higashi, Shingo Isshiki, Hideki Sasaki
Infection by Nocardia sp. is rare and usually affects immuno-depressed patients, such as those receiving chemotherapy and long-term steroid therapy. Cardiac involvement is uncommon and usually occurs as endocarditis. We present a case of native aortic valve endocarditis caused by Nocardia asteroides. Aortic valve translocation method was chosen because of extensive root infection with major disruption of the aortic annulus. Over 2 years after the surgery, there is no recurrence and no enlargement of the aortic annulus...
December 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29218388/correlation-of-sociodemographic-and-clinical-parameters-with-depression-and-distress-in-patients-with-hematologic-malignancies
#8
Amanda J Shreders, Shehzad K Niazi, David O Hodge, Nicolette T Chimato, Megha Kureti, Navya Kirla, Ankit Agrawal, Abhisek Swaika, Elaine Gustetic, Renee Foster, Kimberly A Nelson, Prachi Jani, Asher A Chanan-Khan, Sikander Ailawadhi
A quarter of cancer patients struggle with distress or depression during their illness. Multiple organizations including the National Comprehensive Cancer Network recommend universal screening for distress and depression. Herein, we describe a universal screening program in patients with hematologic malignancies and factors associated with distress and depression. Between December 2013 and February 2015, patients with hematologic malignancies took the Patient Health Questionnaire 9 (PHQ-9) and Distress Thermometer (DT) prior to receiving their first outpatient parenteral chemotherapy...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29212735/decision-making-capacity-for-chemotherapy-and-associated-factors-in-newly-diagnosed-patients-with-lung-cancer
#9
Asao Ogawa, Kyoko Kondo, Hiroyuki Takei, Daisuke Fujisawa, Yuichiro Ohe, Tatsuo Akechi
BACKGROUND: The objective of this study was to assess decision-making capacity in patients newly diagnosed with lung cancer, clinical factors associated with impaired capacity, and physicians' perceptions of patients' decision-making capacity. MATERIALS AND METHODS: We recruited 122 patients newly diagnosed with lung cancer. One hundred fourteen completed the assessment. All patients were receiving a combination of treatments (e.g., chemotherapy, chemo-radiotherapy, or targeted therapy)...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29209529/patient-reported-pain-severity-pain-interference-and-health-status-in-hr-her2-advanced-metastatic-breast-cancer
#10
Robert Wood, Debanjali Mitra, Jonathan de Courcy, Shrividya Iyer
Introduction: Patient-reported pain severity and related impact in advanced/metastatic breast cancer (ABC/MBC) are not well documented. The objective of this study was to assess pain and general health status in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) ABC/MBC. Methods: Data were collected in the USA and Europe in a real-world, cross-sectional study. Patients were recruited at oncology practices and completed validated questionnaires; pain severity and interference were assessed using the Brief Pain Inventory (BPI) and general health status using the EuroQoL-5D (EQ-5D-3L)...
2017: ESMO Open
https://www.readbyqxmd.com/read/29179467/knockdown-of-long-non-coding-rna-taurine-up-regulated-1-inhibited-doxorubicin-resistance-of-bladder-urothelial-carcinoma-via-wnt-%C3%AE-catenin-pathway
#11
Dalong Xie, Hui Zhang, Xuanhao Hu, Chao Shang
In genitourinary system, bladder cancer (BC) is the most common and lethal malignant tumor, which most common type is bladder urothelial carcinoma (BUC). Long non-coding RNA (lncRNA) Taurine Up-Regulated 1 (TUG1) gene is high-expressed in several malignant tumors, including BC. In this study, over-expression of TUG1 was found in BUC tissues and cell line resistant to doxorubicin (Dox). Knockdown of TUG1 inhibited the Dox resistance and promoted the cytotoxicity induced by Dox in T24/Dox cells. TUG1 knockdown also depressed the Wnt/β-catenin pathway, and the activation the Wnt/β-catenin pathway partly reversed the inhibitory effects of TUG1 knockdown on Dox resistance in T24/Dox cells...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29164561/study-of-prevalence-and-influencing-factors-of-depression-in-tumor-patients-and-the-therapeutic-effects-of-fluoxetine
#12
J Dai, N Liao, J Shi, J-Q Tao
OBJECTIVE: To observe the depression in patients with malignant tumor and influencing factors of the disease, as well as to investigate the effects of fluoxetine on depressive symptoms in cancer patients and the immune function. PATIENTS AND METHODS: 262 patients with malignant tumors, confirmed by pathological and radiological diagnosis as malignant tumor were randomly divided into 2 groups: the control group with chemotherapy; the treatment group with chemotherapy and 20 mg/d fluoxetine for six weeks...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29155948/predictors-of-fatigue-and-work-ability-in-cancer-survivors
#13
P van Muijen, S F A Duijts, K Bonefaas-Groenewoud, A J van der Beek, J R Anema
Background: Workers diagnosed with cancer are at risk for job loss or work disability. Aims: To determine predictors of fatigue and work ability at 36 months after diagnosis in a population of cancer survivors. Methods: Individuals diagnosed with cancer and who applied for work disability benefit at 24 months of sick leave were surveyed at the time of application and again 12 months later. Fatigue was measured using the Functional Assessment of Chronic Illness-Fatigue scale questionnaire and work ability was measured using the work ability index...
November 16, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29153555/a-prospective-follow-up-of-quality-of-life-depression-and-anxiety-in-children-with-lymphoma-and-solid-tumors
#14
Nihal Sargın Yıldırım, Metin Demirkaya, Betül Berrin Sevinir, Salih Güler, Ayşe Pınar Vural, Candan Demiröz, Arzu Çırpan Kantarcıoğlu
Background/aim: The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors. Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used. Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and in the group of patients whose diagnosis was delayed for more than 3 months...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29145033/is-chronic-postsurgical-pain-surgery-induced-a-study-of-persistent-postoperative-pain-following-breast-reconstruction
#15
Randy S Roth, Ji Qi, Jennifer B Hamill, Hyungjin M Kim, Tiffany N S Ballard, Andrea L Pusic, Edwin G Wilkins
BACKGROUND: Chronic postsurgical pain (CPSP) is a reported risk for women undergoing breast reconstruction, but it remains unclear that such persistent pain is induced by reconstructive surgery. To address this concern, this prospective cohort study examined the prevalence of and risk factors associated with CPSP among women undergoing breast reconstruction. MATERIALS AND METHODS: Women (n = 1996) recruited for the Mastectomy Reconstruction Outcomes Consortium (MROC) Study were assessed preoperatively and at two-years postoperatively for relevant medical/...
November 13, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29126815/analysis-of-suicide-risk-in-patients-with-penile-cancer-and-review-of-the-literature
#16
REVIEW
William G Simpson, Zachary Klaassen, Rita P Jen, William M Hughes, Durwood E Neal, Martha K Terris
The treatment for penile cancer has been shown to cause harmful psychiatric symptoms as well as have detrimental effects on well-being. In the past several years, alternatives to total or partial penectomy have emerged, such as chemotherapy, radiation, penile sparing, and laser ablation therapies. A more specific breakdown for penile cancer is in order as the therapy has the potential for life changing surgery. We examined the Surveillance, Epidemiology, and End Results (SEER) database (1973-2013), comprising 28% of the United States population...
October 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29123662/chronic-postsurgical-pain-is-there-a-possible-genetic-link
#17
Sabu Kumar James
Persistent or chronic postsurgical pain (CPSP) has been defined as 'pain persisting beyond 2 months'. The cut-off limit of 2 months has been controversial, and some researchers argue for a 3-month period for the definition of CPSP. Multiple mechanisms, including both patient and surgical, have been shown to influence this transition. Patient factors include age, gender, anxiety, depression, somatisation, catastrophising, pre-existing pain anywhere and pain at the site of surgery. The various surgical factors include site and nature of surgery, infection, inflammation and repeat surgery...
November 2017: British Journal of Pain
https://www.readbyqxmd.com/read/29123357/complementary-therapies-for-symptom-management-in-cancer-patients
#18
Aanchal Satija, Sushma Bhatnagar
Cancer patients are often poly-symptomatic which distressingly affects their quality of lives (QOLs). Alhough, conventional management provides adequate symptom control, yet is coupled with some limitations. Complementary therapies (CTs) have shown beneficial effects in cancer patients for symptomatic relief. The aim of this article is to provide evidence-based review of commonly used CTs for symptom management in cancer care. Hypnosis has promising evidence to be used for managing symptoms such as pain, chemotherapy-induced nausea/vomiting, distress, fatigue, and hot flashes...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29123345/effect-of-supportive-psychotherapy-on-mental-health-status-and-quality-of-life-of-female-cancer-patients-receiving-chemotherapy-for-recurrent-disease
#19
Anindita Mukherjee, Koustav Mazumder, Vikrant Kaushal, Sushmita Ghoshal
Context: Cancer patients receiving chemotherapy for their recurrent disease often report the presence of anxiety and depression. Aims: In the study, we intended to find out the mental health status and overall quality of life (QOL) of such patients and to identify the effect of supportive psychotherapy. Subjects and Methods: Forty cancer patients undergoing second or subsequent line chemotherapy(CCT) were selected for psychotherapy session...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29116555/modifiable-correlates-of-perceived-cognitive-function-in-breast-cancer-survivors-up-to-10%C3%A2-years-after-chemotherapy-completion
#20
Ashley Henneghan, Alexa Stuifbergen, Heather Becker, Shelli Kesler, Elisabeth King
BACKGROUND: Cognitive changes following breast cancer treatment are likely multifactorial and have been linked to emotional factors, biophysiological factors, and fatigue, among others. Little is known about the contributions of modifiable factors such as stress, loneliness, and sleep quality. The purpose of this study was to explore the direct and indirect effects of perceived stress, loneliness, and sleep quality on perceived cognitive function (PCF) in breast cancer survivors (BCS) after chemotherapy completion...
November 7, 2017: Journal of Cancer Survivorship: Research and Practice
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