Xinran Wang, Ningxin Chen, Pablo Cruz-Morales, Biming Zhong, Yangming Zhang, Jian Wang, Yifan Xiao, Xinnan Fu, Yang Lin, Suneil Acharya, Zhibo Li, Huaxiang Deng, Yuhui Sun, Linquan Bai, Xiaoyu Tang, Jay D Keasling, Xiaozhou Luo
Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have larger BGC repertoires than others, we proposed that a set of genes co-evolved with BGCs to support biosynthetic proficiency must exist in those strains, and that their identification may provide universal strategies to improve the productivity of other strains. We show here that genes co-evolved with natural product BGCs in Streptomyces can be identified by phylogenomics analysis...
April 12, 2024: Nature metabolism