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https://www.readbyqxmd.com/read/28324763/interaction-of-apoe-e4-and-poor-glycemic-control-predicts-white-matter-hyperintensity-growth-from-73-to-76
#1
Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio...
February 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28319592/trends-in-prevalence-awareness-treatment-and-control-of-high-blood-pressure-in-the-seychelles-between-1989-and-2013
#2
Samuel Heiniger, Bharathi Viswanathan, Jude Gedeon, Fred Paccaud, Pascal Bovet
BACKGROUND: Limited data are available in the African region on trends in blood pressure (BP) and awareness, treatment and control rates. OBJECTIVE: We examined trends in these indicators for a 25-year period in the Seychelles, a rapidly developing small island state in the African region. METHODS: Population-based surveys of adults aged 25-64 years were performed in 1989, 1994, 2004 and 2013 using nearly identical methods for all surveys...
March 17, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28319581/can-claims-data-algorithms-identify-the-physician-of-record
#3
Eva H DuGoff, Emily Walden, Katie Ronk, Mari Palta, Maureen Smith
BACKGROUND: Claims-based algorithms based on administrative claims data are frequently used to identify an individual's primary care physician (PCP). The validity of these algorithms in the US Medicare population has not been assessed. OBJECTIVE: To determine the agreement of the PCP identified by claims algorithms with the PCP of record in electronic health record data. DATA: Electronic health record and Medicare claims data from older adults with diabetes...
March 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28318640/the-prevalence-of-diabetic-retinopathy-in-australian-adults-with-self-reported-diabetes-the-national-eye-health-survey
#4
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To determine the prevalence of and factors associated with diabetic retinopathy (DR) among non-Indigenous and Indigenous Australian adults with self-reported diabetes. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Non-Indigenous Australians (50-98 years of age) and Indigenous Australians (40-92 years of age) with known diabetes. METHODS: Diabetes was determined based on self-report of previous diagnosis of the disease...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28314656/safety-and-efficacy-of-a-basal-plus-regimen-with-insulin-glargine-and-insulin-glulisine-for-elderly-patients-with-high-cardiovascular-risk-and-type-2-diabetes-mellitus
#5
R Gómez-Huelgas, J Sabán-Ruiz, F J García-Román, N Quintela-Fernández, J M Seguí-Ripoll, M V Bonilla-Hernández, G Romero-Meliá
OBJECTIVES: To assess the safety and efficacy of a basal-plus (BP) regimen with insulin glargine (as basal insulin) and insulin glulisine (as prandial insulin) with the main meal for elderly patients with type 2 diabetes mellitus (DM2) and high cardiovascular risk, following standard clinical practice. PATIENTS AND METHODS: An observational, retrospective study was conducted in 21 centres of internal medicine in Spain. The study included patients aged 65 years or older with DM2, undergoing treatment with a BP regimen for 4 to 12 months before inclusion in the study and a diagnosis of cardiovascular disease or high cardiovascular risk...
March 14, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28314537/prevalence-of-diabetes-type-2-in-older-adults-findings-from-a-large-population-based-survey-in-tehran-iran-urban-heart-2
#6
Vahid Rashedi, Mohsen Asadi-Lari, Ahmad Delbari, Reza Fadayevatan, Vahidreza Borhaninejad, Mahshid Foroughan
AIMS: Diabetes is a common problem in older adults, as they increasingly comprise a larger proportion of patients newly diagnosed with diabetes. The evidence on the prevalence and distribution of type 2 diabetes (DT2) and its related factors among older adults in Iran is sparse. The aim of the present study was to determine the prevalence of DT2 among Iranian older adults aged ≥60years. MATERIALS AND METHODS: The study was part of a comprehensive survey (Urban HEART-2) which was a large population-based cross-sectional study...
March 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28314486/insulin-provision-therapy-and-mortality-in-older-adults-with-diabetes-mellitus-and-stable-ischemic-heart-disease-insights-from-bari-2d-trial
#7
Abdulla A Damluji, Erin R Cohen, Mauro Moscucci, Robert J Myerburg, Mauricio G Cohen, Maria M Brooks, Michael W Rich, Daniel E Forman
IMPORTANCE: Optimal strategies for glucose control in very old adults with diabetes and stable ischemic heart disease (SIHD) are unclear. OBJECTIVE: To compare the effects of insulin provision (IP) therapy versus insulin sensitizing (IS) therapy for glycemic control in older (≥75years) and younger (<75years) adults with type II diabetes (DM) and SIHD. DESIGN, SETTING, AND PARTICIPANTS: Adults enrolled in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) were studied...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28303668/beliefs-about-medicines-among-older-hospital-outpatients-in-hong-kong
#8
Bosco K F Wan, Walter H K Cheung, Patrick A Ball, David M Jackson, Gregg J Maynard
OBJECTIVES: (1) To identify demographic characteristics associated with different patients' belief attitudes and assess any correlation between medication beliefs and adherence among older Hong Kong hospital outpatients. (2) To identify important implementation criteria for developing a more effective adherence-improving intervention. METHODS: Six hundred and ninety-eight patients completed a questionnaire consisting of demographic information, Morisky Medications Adherence Scale-8 (MMAS-8) and Belief about Medicines Questionnaire...
March 16, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28303367/effects-of-long-term-multicomponent-exercise-on-health-related-quality-of-life-in-older-adults-with-type-2-diabetes-evidence-from-a-cohort-study
#9
Liliana C Baptista, Gonçalo Dias, Nelba R Souza, Manuel T Veríssimo, Raul A Martins
PURPOSE: To establish the effect of a long-term multicomponent exercise (LTMEX) intervention (24 months) on health-related quality of life (HRQoL), in older adults with type 2 diabetes (T2D). METHODS: This longitudinal retrospective cohort study analyzes the effects of a supervised LTMEX program on HRQoL in older adults with T2D (n = 279). Participants underwent one of two conditions: LTMEX (n = 241) trained three times per week; and unchanged lifestyle-the control group (CO; n = 38)...
March 16, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28303255/active-use-of-electronic-health-records-ehrs-and-personal-health-records-phrs-for-epidemiologic-research-sample-representativeness-and-nonresponse-bias-in-a-study-of-women-during-pregnancy
#10
Julie K Bower, Claire E Bollinger, Randi E Foraker, Darryl B Hood, Abigail B Shoben, Albert M Lai
INTRODUCTION: With the growing use of electronic medical records, electronic health records (EHRs), and personal health records (PHRs) for health care delivery, new opportunities have arisen for population health researchers. Our objective was to characterize PHR users and examine sample representativeness and nonresponse bias in a study of pregnant women recruited via the PHR. DESIGN: Demographic characteristics were examined for PHR users and nonusers. Enrolled study participants (responders, n=187) were then compared with nonresponders and a representative sample of the target population...
2017: EGEMS
https://www.readbyqxmd.com/read/28303060/evaluation-of-the-association-between-locomotive-syndrome-and-depressive-states-a-cross-sectional-study
#11
Tomohiro Saito, Hideaki Watanabe, Ichiro Kikkawa, Katsushi Takeshita
The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some patients owing to their lack of motivation. We speculated that locomotive syndrome and depressive states co-exist in elderly people. The purpose of this study was to determine the presence or absence of depressive states in older patients aged ≥ 65 years who were diagnosed with locomotive syndrome...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28301532/factors-associated-with-study-completion-in-patients-with-premature-acute-coronary-syndrome
#12
Anthony W Austin, Roxanne Pelletier, Louise Pilote, Doreen M Rabi
BACKGROUND: Factors associated with study completion in younger adults are not well understood. This study sought to describe psychosocial, clinical, and demographic features associated with completion of a study of men and women with premature acute coronary syndrome. METHODS: As part of the GENdEr and Sex determInantS of cardiovascular disease: From bench to beyond-Premature Acute Coronary Syndrome (GENESIS-PRAXY) study, demographic, psychosocial, and clinical variables were assessed in 1213 patients hospitalized for acute coronary syndrome (≤ 55 years; 30% women)...
2017: PloS One
https://www.readbyqxmd.com/read/28300627/serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#13
Cristina Pellegrino Baena, Claudia Kimie Suemoto, Sandhi Barreto, Paulo Lotufo, Isabela Benseñor
BACKGROUND: Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. PURPOSE: We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. METHODS: We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA...
March 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28300432/risk-of-nonfatal-stroke-in-type-2-diabetes-mellitus-patients
#14
Stefan Wiefarn, Christian Heumann, Anja Rettelbach, Karel Kostev
OBJECTIVE: The present retrospective study examines the influence of disease management programs on nonfatal stroke in type 2 diabetes mellitus (T2DM) patients in Germany. METHODS: The evaluation is based on retrospective patient data from the Disease Analyzer (IMS Health). The analysis included 169 414 T2DM patients aged 40 years and older with an initial prescription of antihyperglycemic therapy between January 2004 and December 2014. A total of 86 713 patients participated in a disease management program (DMP) for T2DM and 82 701 patients received standard care...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28300335/risk-factors-for-cardiovascular-disease-in-patients-with-hidradenitis-suppurativa
#15
Caroline Vinkel, Simon Francis Thomsen
We read with great interest the article by Pascual et al., in which subclinical atherosclerosis in patients with hidradenitis suppurativa (HS) was assessed using carotid ultrasound. They found a higher prevalence of subclinical atherosclerosis in HS patients (30.7%) compared with controls (16.1%) and the association was significant in patients 40 years and older. Furthermore, traditional cardiovascular (CV) risk factors like hypertension (41.9%), diabetes mellitus (22.6%), and metabolic syndrome (38.7%) along with elevated systemic inflammatory markers including high-sensitivity C-reactive protein (Hs-CRP) (61...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28299634/prevalence-and-determinants-of-the-use-of-lipid-lowering-agents-in-a-population-of-older-hospitalized-patients-the-findings-from-the-reposi-registro-politerapie-societ%C3%A3-italiana-di-medicina-interna-study
#16
Marco Bertolotti, Carlotta Franchi, Marco B L Rocchi, Andrea Miceli, M Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi
BACKGROUND: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. AIM: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. METHODS: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28299033/the-association-of-age-and-gender-with-risk-factors-of-noncommunicable-diseases-among-employees-in-west-of-iran
#17
Nahid Khademi, Mehran Babanejad, Atefeh Asadmobini, Hossein Karim
BACKGROUND: The relationships that age and gender share with risk factors (RFs) of noncommunicable diseases (NCDs) were assessed among a large-scale employ in Western Iran. METHODS: In this epidemiologic cross-sectional study, 7129 employees from Kermanshah Province were assessed using a census method in 2012. Data on RFs of NCD were collected using a standard questionnaire. Demographic information, diet, physical activity, tobacco use, and history of hypertension, history of diabetes, cardiovascular diseases, osteoporosis, and cancer were studied...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28298367/incidence-risk-factors-and-clinical-outcomes-of-acute-kidney-injury-associated-with-scrub-typhus-a-retrospective-study-of-510-consecutive-patients-in-south-korea-2001-2013
#18
Kyungo Hwang, Ha Nee Jang, Tae Won Lee, Hyun Seop Cho, Eunjin Bae, Se-Ho Chang, Dong Jun Park
OBJECTIVES: Renal involvement in scrub typhus ranges from simple urinary abnormalities to acute kidney injury (AKI) leading to death. This study evaluated the incidence, predictors and prognosis of AKI associated with scrub typhus according to the RIFLE (risk, injury, failure, loss, end-stage kidney disease) criteria. METHODS: We retrospectively evaluated the medical records of patients diagnosed with scrub typhus from January 2001 to November 2013 in Gyeongsang National University Hospital...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28298205/prevalence-and-determinants-of-erectile-dysfunction-among-diabetic-patients-attending-in-hospitals-of-central-and-northwestern-zone-of-tigray-northern-ethiopia-a-cross-sectional-study
#19
Awole Seid, Hadgu Gerensea, Shambel Tarko, Yosef Zenebe, Rahel Mezemir
BACKGROUND: The prevalence of erectile dysfunction among diabetic men varies between 35-90%. Although erectile dysfunction is widespread among men with diabetes, the condition often remains undiagnosed and demands appropriate assessment and prompt treatment. Erectile dysfunction can affect all aspects of a patient's life including physical, emotional, social, sexual, and relationships. The main aim of this study is to determine the prevalence and determinants of erectile dysfunction among diabetic patients attending hospitals in the Central and Northwest zone of Tigray, Ethiopia...
March 15, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28296923/screening-gestational-diabetes-mellitus-the-role-of-maternal-age
#20
Chun-Heng Kuo, Szu-Chi Chen, Chi-Tai Fang, Feng-Jung Nien, En-Tzu Wu, Shin-Yu Lin, Lee-Ming Chuang, Chien-Nan Lee, Hung-Yuan Li
OBJECTIVE: Using a specific cutoff of fasting plasma glucose (FPG) to screen gestational diabetes mellitus (GDM) can reduce the use of oral glucose tolerance tests (OGTT). Since the prevalence of GDM increases with age, this screening method may not be appropriate in healthcare systems where women become pregnant at older ages. Therefore, we aimed to develop a screening algorithm for GDM that takes maternal age into consideration. METHODS: We included 945 pregnant women without history of GDM who received 75g OGTT to diagnose GDM in 2011...
2017: PloS One
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