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https://www.readbyqxmd.com/read/29232645/pre-optimization-of-spinal-surgery-patients-development-of-a-neurosurgical-enhanced-recovery-after-surgery-eras-protocol
#1
Zarina S Ali, Tracy S Ma, Ali K Ozturk, Neil R Malhotra, James M Schuster, Paul J Marcotte, M Sean Grady, William C Welch
OBJECTIVE: Despite surgical, technological, medical, and anesthetic improvements, patient outcomes following elective neurosurgical procedures can be associated with high morbidity. Enhanced recovery after surgery (ERAS) protocols are multimodal care pathways designed to optimize patient outcomes by addressing pre-, peri-, and post-operative factors. Despite significant data suggesting improved patient outcomes with the adoption of these pathways, development and implementation has been limited in the neurosurgical population...
December 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29232600/a-retrospective-review-of-phyllodes-tumours-of-the-breast-a-single-institution-experience
#2
Vithusha Ganesh, Leah Drost, Justin Lee, Bo Angela Wan, Liying Zhang, Eileen Rakovitch, Danny Vesprini, Elzbieta Slodkowska, K Liang Zeng, Philomena Sousa, Caitlin Yee, Henry Lam, Edward Chow
BACKGROUND: Phyllodes tumours are rare and histologically diverse, posing challenges in prognosis and treatment. Due to their rarity, they have seldom been studied. PURPOSE: The purpose was to investigate clinical practices in the management of phyllodes tumours, as well as patient outcomes to contribute to the limited body of knowledge surrounding these tumours. METHODS: A retrospective review was conducted on all patients with phyllodes tumours at a single institution...
December 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#3
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29232298/use-of-a-new-expanded-polytetrafluoroethylene-multichordal-mitral-apparatus-mitrapatch-to-repair-complex-mitral-valve-lesions
#4
Surendra K Chawla, Muralidhar Padala, W Randolph Chitwood, Robert W M Frater
OBJECTIVE: We report a new expanded polytetrafluoroethylene multichordal mitral apparatus (MitraPatch) to simplify mitral repairs involving multiple cusps and sought to describe the surgical technique and demonstrate the efficacy of the device. METHODS: MitraPatch was laser cut from a single sheet of expanded polytetrafluoroethylene and mounted on a custom-designed handle. Surgical technique to deploy the apparatus on the native mitral valve was developed in ex vivo porcine hearts...
December 7, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29232184/feasibility-and-safety-of-intrathoracic-biopsy-and-repeat-biopsy-for-evaluation-of-programmed-cell-death-ligand-1-expression-for-immunotherapy-in-non-small-cell-lung-cancer
#5
Emily B Tsai, Kelsey Pomykala, Kathleen Ruchalski, Scott Genshaft, Fereidoun Abtin, Antonio Gutierrez, Hyun J Kim, Alice Li, Carlos Adame, Ashkan Jalalian, Brian Wolf, Edward B Garon, Jonathan W Goldman, Robert Suh
Purpose To determine feasibility and safety of biopsy and repeat biopsy for assessment of programmed cell death ligand-1 (PD-L1) status. Materials and Methods This retrospective analysis reviewed 101 patients who underwent transthoracic core needle biopsy for the KEYNOTE-001 (MK-3475) clinical trial of pembrolizumab, an antiprogrammed cell death-1 therapy for non-small cell lung cancer, from May 2012 to September 2014. Sixty-one male patients (mean age, 66.1 years; range 36-83 years) and 40 female patients (mean age, 66...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29232038/novel-techniques-and-preliminary-results-of-ex-vivo-liver-resection-and-autotransplantation-for-end-stage%C3%A2-hepatic-alveolar-echinococcosis-a-study-of-31-cases
#6
Xianwei Yang, Yiwen Qiu, Bin Huang, Wentao Wang, Shu Shen, Xi Feng, Yonggang Wei, Jianyong Lei, Jichun Zhao, Bo Li, Tianfu Wen, Lunan Yan
Ex vivo liver resection combined with autotransplantation is a recently introduced approach to cure end-stage hepatic alveolar echinococcosis (HAE), which is considered unresectable by conventional radical resection due to echinococcal dissemination into the crucial intrahepatic conduits and adjacent structures. This manuscript aims discuss the manipulation details and propose reasonable indications for this promising technique. All patients successfully underwent liver autotransplantation with no intraoperative mortality...
December 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29231951/phonomicrosurgery-in-vocal-fold-nodules-quantification-of-outcomes-in-professional-and-non-professional-voice-users
#7
Philipp P Caffier, Tatjana Salmen, Tatiana Ermakova, Eleanor Forbes, Seo-Rin Ko, Wen Song, Manfred Gross, Tadeus Nawka
There are few data demonstrating the specific extent to which surgical intervention for vocal fold nodules (VFN) improves vocal function in professional (PVU) and non-professional voice users (NVU). The objective of this study was to compare and quantify results after phonomicrosurgery for VFN in these patient groups. METHODS: In a prospective clinical study, surgery was performed via microlaryngoscopy in 37 female patients with chronic VFN manifestations (38±12 yrs, mean±SD). Pre- and postoperative evaluations of treatment efficacy comprised videolaryngostroboscopy, auditory-perceptual voice assessment, voice range profile (VRP), acoustic-aerodynamic analysis, and voice handicap index (VHI-9i)...
December 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/29231253/internal-venous-anomalies-in-patients-with-a-genital-venous-malformation
#8
Caitlin M Peterman, Patricia S Todd, Anna P Lillis, Steven J Fishman, Marilyn G Liang
BACKGROUND: Cutaneous venous malformation (VM) can be associated with internal vascular anomalies. Our objective was to investigate the frequency of internal vascular anomalies in patients with an isolated genital venous malformation to assess the utility of screening for internal findings. METHODS: We retrospectively reviewed our Vascular Anomalies Center database for patients with a focal genital venous malformation presenting between 1999 and 2016. Abdominal and pelvic imaging reports were reviewed for internal vascular anomalies...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29230940/the-effects-of-recreational-ketamine-cystitis-on-urinary-tract-reconstruction-a-surgical-challenge
#9
Néha Sihra, Jeremy Ockrim, Dan Wood
OBJECTIVES: To identify the rate of post-operative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor post-operative outcome with subsequent management strategies. MATERIALS AND METHODS: A retrospective review of data collected between 2007 and 2017 was performed. Evaluation included CT urogram, cystoscopy and biopsy. Indications and outcomes for surgical intervention were assessed...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29230496/testicle-sparing-surgery-versus-radical-orchiectomy-in-the-management-of-leydig-cell-tumors-results-from-a-multicenter-study
#10
Florian Laclergerie, Guillaume Mouillet, Alexandre Frontczak, Loïc Balssa, Pascal Eschwege, Christian Saussine, Stéphane Larré, Luc Cormier, Antoine Thiery Vuillemin, François Kleinclauss
OBJECTIVE: To compare the oncological outcomes of testicle-sparing surgery (TSS) and radical orchiectomy (RO) in patients with Leydig cell tumor (LCT) of the testis. PATIENTS AND METHODS: A multicenter retrospective clinical study was conducted in 12 centers in France. All the patients with histologically proven LCT were included and analyzed according to treatment (organ-sparing surgery or radical orchiectomy). Patients underwent preoperative clinical, biological and imaging assessment...
December 11, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29230415/hypoxia-induces-apoptosis-through-hif-1%C3%AE-signaling-pathway-in-human-uterosacral-ligaments-of-pelvic-organ-prolapse
#11
Xinrui Zhao, Congcong Ma, Rui Li, Jing Xue, Lidong Liu, Peishu Liu
The purpose of this study is to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) in women uterosacral ligament tissues with pelvic organ prolapse and women with normal uterine support structures and illuminate its relationship with apoptosis. Samples were collected from 38 women with pelvic organ prolapse and 31 age matched controls. The expression levels of HIF-1α and BNIP3 in the uterosacral ligaments were measured using immunohistochemistry, qRT-PCR, and Western blot. To assess apoptosis we performed TUNEL assay and Western blot analyses...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230296/intestinal-autotransplantation
#12
REVIEW
Guosheng Wu
Most abdominal neoplasms involving the root of the superior mesenteric artery and/or celiac artery are difficult to manage with conventional operative techniques because of limited intestinal ischemia times and poor accessibility to the tumor region. Ex vivo surgery followed by intestinal autotransplantation (IATx) is a relatively novel surgical strategy to offer chances for complete resection in such hopeless circumstances. This review aims to assess potential surgical indications, operative techniques and clinical outcomes after IATx...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29230119/a-potential-additional-variable-to-consider-in-the-surgical-treatment-of-ductal-carcinoma-in-situ
#13
Katherine Chaisson, Amy Rivere, Ralph Corsetti, Tova Weiss, George M Fuhrman
Background: HER2/neu is a potentially interesting variable that has been demonstrated to have a profound impact on the management of invasive breast carcinoma, and we performed this study to evaluate the differences between HER2-positive and HER2-negative ductal carcinoma in situ. The impetus for this study was our poor recruitment to the National Surgical Adjuvant Breast and Bowel Project Protocol B-43 trial that was designed to evaluate the potential role of trastuzumab in breast conservation therapy for patients with HER2-positive ductal carcinoma in situ...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29230008/positive-margin-length-and-highest-gleason-grade-of-tumor-at-the-margin-predict-for-biochemical-recurrence-after-radical-prostatectomy-in-patients-with-organ-confined-prostate-cancer
#14
Brian F Chapin, Jenny N Nguyen, Mary F Achim, Neema Navai, Stephen B Williams, Ina N Prokhorova, Xuemei Wang, Elsa M Li Ning Tapia, John W Davis, Patricia Troncoso
BACKGROUND: To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk stratify patients for biochemical recurrence (BCR). METHODS: We performed a retrospective, matched, cohort study to identify patients with pathologically organ-confined (pT2) tumors and negative nodes (pN0/Nx), receiving no adjuvant therapy. Specimens underwent single pathologist review...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#15
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229746/inhibition-of-nadph-oxidase-dependent-oxidative-stress-in-the-rostral-ventrolateral-medulla-mediates-the-antihypertensive-effects-of-acupuncture-in-spontaneously-hypertensive-rats
#16
Xue-Rui Wang, Jing-Wen Yang, Cai-Shuo Ji, Xiang-Hong Zeng, Guang-Xia Shi, Marc Fisher, Cun-Zhi Liu
Oxidative stress in the rostral ventrolateral medulla (RVLM), where the sympathetic nervous control center is located, contributes to neural mechanisms of hypertension. Acupuncture was previously reported to favorably affect high blood pressure. However, little is known about the effect of acupuncture on oxidative stress-modulated mechanisms in hypertension. This study was designed to evaluate the hypothesis that acupuncture exerts an antihypertensive effect via ameliorating oxidative stress and the redox-sensitive pathway in the RVLM of spontaneously hypertensive rats...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29229541/results-of-percutaneous-fixation-and-distal-radius-core-decompression-in-scaphoid-waist-non-unions-treated-without-grafting
#17
S S Dedeoğlu, Y İmren, H Çabuk, A C Tekin, Y C Türe, H Gürbüz
Scaphoid non-union management is still a challenge in clinical practice for orthopaedic surgeons. Though several treatment methods have been described, there is an ongoing debate about optimum management. Based on new concepts about avascular conditions, promising results were reported with metaphyseal decompression of the distal radius by increasing the vascularization of the radial column of the carpus. We aimed to evaluate the clinical, radiological, and functional outcomes of distal radius core decompression and fixation with palmar percutaneous cannulated compression screws without grafting in patients with scaphoid waist fracture non-union...
December 8, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29229135/intraoperative-factors-associated-with-postoperative-complications-in-body-contouring-surgery
#18
Barak Cohen, Benjamin Meilik, Ahuva Weiss-Meilik, Aviv Tarrab, Idit Matot
BACKGROUND: Several preoperative factors have been shown to influence outcome of body contouring surgeries. The effect of intraoperative features, including fluid volume administered, hemodynamic and respiratory parameters, and body temperature on postoperative complication, has not been reported to date. MATERIALS AND METHODS: All subsequent patients undergoing body contouring surgery in the Tel Aviv Medical Center between 2007 and 2012 were enrolled. Demographic and intraoperative data were collected and analyzed for possible associations with postoperative complications, including formation of seroma, hematoma/bleeding, other surgical site complications (infection, adhesiolysis, or need for debridement), formation of a hypertrophic scar, any documented, infection or a composite outcome of any of the previously mentioned...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29229134/animal-models-in-plastic-and-reconstructive-surgery-simulation-a-review
#19
REVIEW
Charles Yuen Yung Loh, Aline Yen Ling Wang, Vincent Tze Yang Tiong, Thanassi Athanassopoulos, Meiling Loh, Philip Lim, Huang-Kai Kao
BACKGROUND: The use of live and cadaveric animal models in surgical training is well established as a means of teaching and improving surgical skill in a controlled setting. We aim to review, evaluate, and summarize the models published in the literature that are applicable to Plastic Surgery training. MATERIALS AND METHODS: A PubMed search for keywords relating to animal models in Plastic Surgery and the associated procedures was conducted. Animal models that had cross over between specialties such as microsurgery with Neurosurgery and pinnaplasty with ear, nose, and throat surgery were included as they were deemed to be relevant to our training curriculum...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228646/discordance-of-pathological-thin-melanoma-thickness-and-t-stage-in-seer-registry-impacts-on-clinical-management-and-research-directions
#20
Zhichao Wang, Haizhou Li, Xinyang Liu, Jinhong Bae, Xin Huang, Yashan Gao, Xiangwen Xu, Jihan Guo, Lin Lu, Tao Zan, Qingfeng Li
Background: Ultrathin melanoma was previously demonstrated to have higher risk for melanoma-specific mortality using SEER database. However, these guideline-changing conclusions has been recently challenged by miscoding of thickness. This present study was performed to assess the prognosis of thin and ultrathin melanoma using only surgically-treated, pathologically confirmed and after removal of discordant cases. Methods: Melanoma patients from SEER database who were initially diagnosed with histologically confirmed and surgically treated melanoma from 1998 to 2012 were included...
November 17, 2017: Oncotarget
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