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https://www.readbyqxmd.com/read/29144493/adaptive-immune-receptor-repertoire-community-recommendations-for-sharing-immune-repertoire-sequencing-data
#1
Florian Rubelt, Christian E Busse, Syed Ahmad Chan Bukhari, Jean-Philippe Bürckert, Encarnita Mariotti-Ferrandiz, Lindsay G Cowell, Corey T Watson, Nishanth Marthandan, William J Faison, Uri Hershberg, Uri Laserson, Brian D Corrie, Mark M Davis, Bjoern Peters, Marie-Paule Lefranc, Jamie K Scott, Felix Breden, Eline T Luning Prak, Steven H Kleinstein
No abstract text is available yet for this article.
November 16, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29143892/update-in-the-therapy-of-advanced-neuroendocrine-tumors
#2
REVIEW
Inbal Uri, Shani Avniel-Polak, David J Gross, Simona Grozinsky-Glasberg
Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from endocrine cells of the gastrointestinal tract and the pancreas, thus being referred to as gastroenteropancreatic NETs (GEP-NETs). The only treatment that offers a cure is surgery; however, most patients are diagnosed with metastatic disease, and curative surgery is usually not an option. These patients can be offered long-term systemic treatment, for both symptomatic relief and tumor growth suppression...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29142231/evaluation-of-critical-flicker-fusion-frequency-measurement-methods-for-the-investigation-of-visual-temporal-resolution
#3
Auria Eisen-Enosh, Nairouz Farah, Zvia Burgansky-Eliash, Uri Polat, Yossi Mandel
Recent studies highlight the importance of the temporal domain in visual processing. Critical Flicker-Fusion Frequency (CFF), the frequency at which a flickering light is perceived as continuous, is widely used for evaluating visual temporal processing. However, substantial variability in the psychophysical paradigms, used for measuring CFF, leads to substantial variability in the reported results. Here, we report on a comprehensive comparison of CFF measurements through three different psychophysical paradigms: methods of limits; method of constant stimuli, and staircase method...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141186/hyperbaric-oxygen-therapy-ameliorates-pathophysiology-of-3xtg-ad-mouse-model-by-attenuating-neuroinflammation
#4
Ronit Shapira, Beka Solomon, Shai Efrati, Dan Frenkel, Uri Ashery
There is a real need for new interventions for Alzheimer's disease (AD). Hyperbaric oxygen therapy (HBOT), the medical administration of 100% oxygen at conditions greater than 1 atmosphere absolute, has been used successfully to treat several neurological conditions, but its effects on AD pathology have never been thoroughly examined. Therefore, we exposed old triple-transgenic (3xTg) and non-transgenic mice to HBOT followed by behavioral, histological, and biochemical analyses. HBOT attenuated neuroinflammatory processes by reducing astrogliosis, microgliosis, and the secretion of proinflammatory cytokines (IL-1β and TNFα) and increasing expression of scavenger receptor A, arginase1, and antiinflammatory cytokines (IL-4 and IL-10)...
October 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29140773/reply-to-d-t-w-jones-et-al
#5
Uri Tabori, Eric Bouffet, Cynthia E Hawkins
No abstract text is available yet for this article.
November 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29130549/concomitant-idh-wildtype-glioblastoma-and-idh1-mutant-anaplastic-astrocytoma-in-a-patient-with-constitutional-mismatch-repair-deficiency-syndrome
#6
Francesca Galuppini, Enrico Opocher, Uri Tabori, Isabella Mammi, Melissa Edwards, Britany Campbell, Jacalyn Kelly, Alessandra Viel, Michele Quaia, Francesca Rivieri, Domenico D'Avella, Antonella Arcella, Felice Giangaspero, Matteo Fassan, Marina Paola Gardiman
Constitutional mismatch repair deficiency (CMMRD) is a rare and often under-recognized tumour predisposition syndrome, presenting with both extracranial and malignant brain tumours that occur in children and/or young adults [1]. The genetic defects underlying this disease are biallelic germline mutations in one of the DNA mismatch repair (MMR) genes leading to a constitutional DNA repair defect that causes a cancer predisposition syndrome with early onset [2]. This mechanism is different from Lynch syndrome (LS) where a heterozygous germline loss-of-function mutation is observed and the patients are more prone to develop colon and genitourinary cancers as adults [1]...
November 12, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29124851/lower-risk-of-pelvic-metalware-infection-with-operative-repair-of-concurrent-bladder-rupture
#7
Henry H-I Yao, Max Esser, Jeremy Grummet, Chris Atkins, Peter Royce, Uri Hanegbi
BACKGROUND: Patients with traumatic bladder rupture frequently have associated pelvic fracture. With increasing numbers of pelvic fractures fixed internally, there are concerns that conservative management of bladder rupture may increase the risk of pelvic metalware infection. This study aims to determine if operative repair of bladder rupture in comparison to conservative management with catheter drainage alone is associated with a lower rate of infection of internal fixation device for concurrent pelvic fracture...
November 9, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29121208/dynamics-of-bacterial-colonization-with-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis-during-symptomatic-and-asymptomatic-viral-upper-respiratory-infection
#8
Gregory P DeMuri, James E Gern, Jens C Eickhoff, Susan V Lynch, Ellen R Wald
Background: Virus is detected in about 80% of upper respiratory tract infections (URIs) in children and is also detectable in the nasopharynx of 30% of asymptomatic children. The effect of asymptomatic viral infection on the dynamics of bacterial density and colonization of the nasopharynx has not been reported. Objective: To assess the presence and density of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in the nasopharynx of 4 to 7 year old children during URI and when well...
November 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29120753/mitochondrial-oxphos-induced-by-rb1-deficiency-in-breast-cancer-implications-for-anabolic-metabolism-stemness-and-metastasis
#9
REVIEW
Eldad Zacksenhaus, Mariusz Shrestha, Jeff C Liu, Ioulia Vorobieva, Philip E D Chung, YoungJun Ju, Uri Nir, Zhe Jiang
A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid cell duplication, and is driven by multiple oncogenic alterations, including PIK3CA mutation, MYC amplification, and TP53 loss. However, tumor growth requires active mitochondrial function and oxidative phosphorylation (OXPHOS). Recently, loss of the retinoblastoma (RB1) tumor suppressor in breast cancer was shown to induce mitochondrial protein translation (MPT) and OXPHOS. Here, we discuss how increased OXPHOS can enhance anabolic metabolism and cell proliferation, as well as cancer stemness and metastasis...
November 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29117632/living-quarters-of-a-living-fossil-uncovering-the-current-distribution-pattern-of-the-rediscovered-hula-painted-frog-latonia-nigriventer-using-environmental-dna
#10
Sharon Renan, Sarig Gafny, R G Bina Perl, Uri Roll, Yoram Malka, Miguel Vences, Eli Geffen
One of the greatest challenges of effective conservation measures is the correct identification of sites where rare and elusive organisms reside. The recently rediscovered Hula painted frog (Latonia nigriventer) has not been seen for many decades, and was therefore categorized extinct. Since its rediscovery in 2011, individuals from the critically endangered species have been found, with great effort, only in four restricted sites. We applied the environmental DNA (eDNA) approach to search for new populations of the Hula painted frog in suitable aquatic habitats...
November 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29114088/unruptured-brain-arteriovenous-malformations-primary-onyx-embolization-in-aruba-a-randomized-trial-of-unruptured-brain-arteriovenous-malformations-eligible-patients
#11
Uri Singfer, Dimitri Hemelsoet, Peter Vanlangenhove, Frederic Martens, Luc Verbeke, Dirk Van Roost, Luc Defreyne
BACKGROUND AND PURPOSE: In light of evidence from ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations), neurovascular specialists had to reconsider deliberate treatment of unruptured brain arteriovenous malformations (uBAVMs). Our objective was to determine the outcomes of uBAVM treated with primary embolization using ethylene vinyl alcohol (ONYX). METHODS: Patients with uBAVM who met the inclusion criteria of ARUBA and were treated with primary Onyx embolization were assigned to this retrospective study...
November 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29114028/dynamic-proteomics-of-herpes-simplex-virus-infection
#12
Nir Drayman, Omer Karin, Avi Mayo, Tamar Danon, Lev Shapira, Dor Rafael, Anat Zimmer, Anat Bren, Oren Kobiler, Uri Alon
The cellular response to viral infection is usually studied at the level of cell populations. Currently, it remains an open question whether and to what extent cell-to-cell variability impacts the course of infection. Here we address this by dynamic proteomics-imaging and tracking 400 yellow fluorescent protein (YFP)-tagged host proteins in individual cells infected by herpes simplex virus 1. By quantifying time-lapse fluorescence imaging, we analyze how cell-to-cell variability impacts gene expression from the viral genome...
November 7, 2017: MBio
https://www.readbyqxmd.com/read/29113587/streptococcus-pneumoniae-burden-and-nasopharyngeal-inflammation-during-acute-otitis-media
#13
Matthew C Morris, Michael E Pichichero
Streptococcus pneumoniae (Spn) is a common respiratory pathogen and a frequent cause of acute otitis media (AOM) in children. The first step in bacterial pathogenesis of AOM is the establishment of asymptomatic colonization in the nasopharynx. We studied Spn bacterial burden in conjunction with neutrophil recruitment and inflammatory gene transcription and cytokine secretion in samples of nasal wash collected from normal and otitis-prone children during health, viral upper respiratory infection without middle ear involvement (URI) and AOM...
November 2017: Innate Immunity
https://www.readbyqxmd.com/read/29112133/characterization-of-sheep-wool-as-a-sustainable-material-for-acoustic-applications
#14
Romina Del Rey, Antonio Uris, Jesús Alba, Pilar Candelas
In recent years, natural materials are becoming a valid alternative to traditional sound absorbers due to reduced production costs and environmental protection. This paper reports the acoustical characterization of sheep wool. Measurements on normal incidence and diffuse-incidence sound absorption coefficients of different samples are reported. The airflow resistance has also been measured. The results prove that sheep wool has a comparable sound absorption performance to that of mineral wool or recycled polyurethane foam...
November 7, 2017: Materials
https://www.readbyqxmd.com/read/29102170/protection-of-vaccinated-mice-against-pneumonic-tularemia-is-associated-with-an-early-memory-sentinel-response-in-the-lung
#15
Liat Bar-On, Hila Cohen, Uri Elia, Shahar Rotem, Adi Bercovich-Kinori, Erez Bar-Haim, Theodor Chitlaru, Ofer Cohen
Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection against tularemia is a controversial matter. Live attenuated vaccine strains of F. tularensis such as LVS (Live Vaccine Strain), elicit an immune response protecting mice against subsequent challenge with the virulent SchuS4 strain, yet the protective immunity against pulmonary challenge is limited in its efficacy and longevity...
October 25, 2017: Vaccine
https://www.readbyqxmd.com/read/29094627/feasibility-of-homeopathic-treatment-for-symptom-reduction-in-an-integrative-oncology-service
#16
Noah Samuels, Yakov Freed, Rony Weitzen, Merav Ben-David, Yair Maimon, Uri Eliyahu, Raanan Berger
BACKGROUND: Homeopathy has the potential to reduce symptoms related to cancer treatment. The present study examined the feasibility of a homeopathic consultation and treatment program, provided as part of an integrative oncology service. METHODS: The electronic medical files of patients undergoing a homeopathic consultation in an integrative oncology service clinic were examined retrospectively. Adherence to the homeopathic treatment regimen and perceived response to the treatment were evaluated...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29094502/association-between-uterine-position-and-transvaginal-misoprostol-treatment-for-early-pregnancy-failure
#17
Henry H Chill, Nirit Malyanker, Gilad Karavani, Rani Haj-Yahya, Shmuel Herzberg, Raz Bahar, David Shveiky, Uri P Dior
AIM: We aimed to determine the importance of uterine position as a predicting factor of success rate in medically treated early pregnancy failure (EPF). METHODS: We carried out a retrospective cohort study at the Obstetrics and Gynecology Department of a tertiary medical center between January 2011 and June 2012. We included women diagnosed with EPF, which we defined as women diagnosed with missed abortion up to 13 gestational weeks. Patients were treated with one or two doses of 800 μg of misoprostol vaginally in accordance with the department's protocol...
November 2, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29092530/x-ray-spectrometer-having-12-000-resolving-power-at-8-kev-energy
#18
John F Seely, Lawrence T Hudson, Albert Henins, Uri Feldman
An x-ray spectrometer employing a thin (50 μm) silicon transmission crystal was used to record high-resolution Cu Kα spectra from a laboratory x-ray source. The diffraction was from the (331) planes that were at an angle of 13.26° to the crystal surface. The components of the spectral lines resulting from single-vacancy (1s) and double-vacancy (1s and 3d) transitions were observed. After accounting for the natural lifetime widths from reference double-crystal spectra and the spatial resolution of the image plate detector, the intrinsic broadening of the transmission crystal was measured to be as small as 0...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29077833/vedolizumab-in-ibd-lessons-from-real-world-experience-a-systematic-review-and-pooled-analysis
#19
Tal Engel, Bella Ungar, Diana E Yung, Shomron Ben-Horin, Rami Eliakim, Uri Kopylov
Background: Vedolizumab (VDZ) is an anti-integrin monoclonal antibody effective in ulcerative colitis (UC) and Crohn's disease (CD). Several real-world experience (RWE) studies with VDZ were published to date. The aim of this systematic review was to summarize the available real-life experience with VDZ. Methods: We performed a systematic review of the available RWE studies of VDZ in CD and UC. We performed a pooled analysis of the available efficacy and safety data for induction and maintenance treatment in adult cohorts...
October 25, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29076536/assessment-of-laryngeal-cancer-in-patients-younger-than-40-years
#20
Yuval Nachalon, Uri Alkan, Jacob Shvero, Dan Yaniv, Yotam Shkedy, Dror Limon, Aron Popovtzer
OBJECTIVES/HYPOTHESIS: To assess the differences between patients with laryngeal squamous cell carcinoma under 40 years old and those 40 years old or older. A secondary objective was to compare survival outcome between these cohorts. STUDY DESIGN: Retrospective chart review. METHODS: We reviewed the medical charts of all patients treated in our tertiary referral center for laryngeal squamous cell carcinoma from 2005 to 2014. Patients aged < 40 years at diagnosis were compared to older patients...
October 27, 2017: Laryngoscope
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