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Viktor Feldman, Meir Nyska, Niv Marom, Omer Slavin, Yaron S Brin, Uri Farkash, Ezequiel Palmanovich
BACKGROUND: This study was designed to measure transverse forces between the 1st and 2nd metatarsals after reducing the intermetatarsal angle (IMA) in normal and hallux valgus (HV) feet, during non weight-bearing and weight-bearing phases of gait. METHODS: Four cadaver feet, three normal and one with hallux valgus, were used. A new suture button device (CyclaPlex™) composed of screw-type buttons connected with a wire was implanted at the mid-shaft of the 1st and 2nd metatarsals of all the feet...
October 17, 2016: Journal of Orthopaedic Surgery and Research
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
October 16, 2016: Veterinary Dermatology
Uri Elbaz, Kamiar Mireskandari, Nasrin Tehrani, Carl Shen, Saad Khan, Sara Luck, Asim Ali
PURPOSE: To establish a normative database of endothelial cell density (ECD) using in-vivo specular microscopy in children under 5 years old. DESIGN: Cross sectional study. METHODS: Specular microscopy was performed during a clinic visit in cooperative children in the standard upright position. In uncooperative children, specular microscopy was performed in the lateral decubitus position under general anesthesia, prior to surgery for other reasons...
October 13, 2016: American Journal of Ophthalmology
Jonathan Ben-David, Stephen D Atkinson, Yulia Pollak, Gilad Yossifon, Uri Shavit, Jerri L Bartholomew, Tamar Lotan
BACKGROUND: Myxozoa is a speciose group of endoparasitic cnidarians that can cause severe ecological and economic effects. Although highly reduced compared to free-living cnidarians, myxozoans have retained the phylum-defining stinging organelles, known as cnidae or polar capsules, which are essential to initiating host infection. To explore the adaptations of myxozoan polar capsules, we compared the structure, firing process and content release mechanism of polar tubules in myxospores of three Myxobolus species including M...
October 14, 2016: Parasites & Vectors
Alon Kalron, Uri Givon, Lior Frid, Mark Dolev, Anat Achiron
Balance impairment is common in people with multiple sclerosis (PwMS) and frequently impacts quality of life by decreasing mobility and increasing the risk of falling. However, there are only scarce data examining the contribution of specific neurological functional systems on balance measures in MS. Therefore, the primary aim of our study was to examine the differences in posturography parameters and fall incidence according to the pyramidal, cerebellar and sensory systems functional systems in PwMS. The study included 342 PwMS, 211 women and mean disease duration of 8...
2016: PloS One
Uri Aviram
Purpose is to present the mental health rehabilitation reform enacted in Israel in 2000, and to analyze the challenges it faces in its second decade of implementation. Lessons are drawn with regard to other jurisdictions interested in reforming mental health services. Besides reviewing the reform's accomplishments and its contribution to the changes that have occurred in mental health services, the article also assesses the dangers it has to contend with. Analysis focuses on the system's clients, budget, personnel and services-and on its functional environment...
October 13, 2016: Community Mental Health Journal
Colin A Zestcott, Uri Lifshin, Peter Helm, Jeff Greenberg
This research applied insights from terror management theory (TMT; Greenberg, Pyszczynski, & Solomon, 1986) to the world of sport. According to TMT, self-esteem buffers against the potential for death anxiety. Because sport allows people to attain self-esteem, reminders of death may improve performance in sport. In Study 1, a mortality salience induction led to improved performance in a "one-on-one" basketball game. In Study 2, a subtle death prime led to higher scores on a basketball shooting task, which was associated with increased task related self-esteem...
October 13, 2016: Journal of Sport & Exercise Psychology
Edison Ong, Zuoshuang Xiang, Bin Zhao, Yue Liu, Yu Lin, Jie Zheng, Chris Mungall, Mélanie Courtot, Alan Ruttenberg, Yongqun He
Linked Data (LD) aims to achieve interconnected data by representing entities using Unified Resource Identifiers (URIs), and sharing information using Resource Description Frameworks (RDFs) and HTTP. Ontologies, which logically represent entities and relations in specific domains, are the basis of LD. Ontobee ( is a linked ontology data server that stores ontology information using RDF triple store technology and supports query, visualization and linkage of ontology terms. Ontobee is also the default linked data server for publishing and browsing biomedical ontologies in the Open Biological Ontology (OBO) Foundry (http://obofoundry...
October 12, 2016: Nucleic Acids Research
Ehud Chorin, Dan Hu, Charles Antzelevitch, Aviram Hochstadt, Luiz Belardinelli, David Zeltser, Hector Barajas-Martinez, Uri Rozovski, Raphael Rosso, Arnon Adler, Jesaia Benhorin, Sami Viskin
BACKGROUND: The basic defect in long-QT syndrome type III (LQT3) is an excessive inflow of sodium current during phase 3 of the action potential caused by mutations in the SCN5A gene. Most sodium channel blockers reduce the early (peak) and late components of the sodium current (INa and INaL), but ranolazine preferentially reduces INaL. We, therefore, evaluated the effects of ranolazine in LQT3 caused by the D1790G mutation in SCN5A. METHODS AND RESULTS: We performed an experimental study of ranolazine in TSA201 cells expressing the D1790G mutation...
October 2016: Circulation. Arrhythmia and Electrophysiology
Adrián Nieto-Montes de Oca, Anthony J Barley, Rubi N Meza-Lázaro, Uri O García-Vázquez, Joan G Zamora-Abrego, Robert C Thomson, Adam D Leaché
Middle American knob-scaled lizards of the genus Xenosaurus are a unique radiation of viviparous species that are generally characterized by a flattened body shape and a crevice-dwelling ecology. Only eight species of Xenosaurus, one of them with five subspecies (X. grandis), have been formally described. However, species limits within Xenosaurus have never been examined using molecular data, and no complete phylogeny of the genus has been published. Here, we used ddRADseq data from all of the described and potentially undescribed taxa of Xenosaurus to investigate species limits, and to obtain a phylogenetic hypothesis for the genus...
October 5, 2016: Molecular Phylogenetics and Evolution
Lulu Fahoum, Alice Moscovici, Shlomit David, Ron Shaoul, Geila Rozen, Esther G Meyron-Holtz, Uri Lesmes
SCOPE: The objective of this study was to interrogate two mechanisms by which commercial Carrageenans (E407) (CGN) may adversely affect human health: [i] Through modification of gastric proteolysis and [ii] Through affecting gut epithelial structure and function. METHODS AND RESULTS: Three commercial CGN samples with distinct zeta-potentials (stable at the pH range of 3-7 and varied with physiological levels of CaCl2 ) were mixed with milk, soy or egg protein isolates, then subjected to a semi-dynamic in vitro digestion model and analyzed by SDS-PAGE...
October 8, 2016: Molecular Nutrition & Food Research
Assi Dahan, Lior Noy, Yuval Hart, Avi Mayo, Uri Alon
Motion synchrony correlates with effective and well-rated human interaction. However, people do not remain locked in synchrony; Instead, they repeatedly enter and exit synchrony. In many important interactions, such as therapy, marriage and parent-infant communication, it is the ability to exit and then re-enter synchrony that is thought to build strong relationship. The phenomenon of entry into zero-phase synchrony is well-studied experimentally and in terms of mathematical modeling. In contrast, exit-from-synchrony is under-studied...
2016: PloS One
Elisabeth H Ference, Jin-Young Min, Rakesh K Chandra, James W Schroeder, Jody D Ciolino, Amy Yang, Jane Holl, Stephanie Shintani Smith
BACKGROUND: This study investigates differences in antibiotic prescribing rates for pediatric upper respiratory infections (URIs) between physicians and nurse practitioners (NPs). METHODS: Visits by children <18 years old diagnosed with URI to physicians or NPs between 2001 and 2010 were abstracted from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Care Survey. Logistic regression analyses examined variations in antibiotic prescribing rates...
October 5, 2016: Annals of Otology, Rhinology, and Laryngology
Anna Melkov, Raju Baskar, Yehonatan Alcalay, Uri Abdu
Intrinsic cell microtubule (MT) polarity, together with molecular motors and adaptor proteins, determines mitochondrial polarized targeting and MT-dependent transport. In polarized cells, such as neurons, mitochondrial mobility and transport require the regulation of kinesin and dynein by two adaptor proteins, Milton and Miro. Recently, we found that dynein heavy chain 64C (Dhc64C) is the primary motor protein for both anterograde and retrograde transport of mitochondria in the Drosophila bristle. In this study, we revealed that a molecular lesion in the Dhc64C allele that reduced bristle mitochondrial velocity generated a variant that acts as a "slow" dynein in a MT gliding assay, indicative of dynein directly regulating mitochondrial transport...
October 5, 2016: Development
Wenya Linda Bi, Peleg Horowtiz, Noah Greenwald, Malak Abedalthagafi, Pankaj K Agarwalla, William J Gibson, Yu Mei, Steven E Schumacher, Uri Ben-David, Aaron Chevalier, Scott L Carter, Grace Tiao, Priscilla K Brastianos, Azra H Ligon, Matthew Ducar, Laura E MacConaill, Edward R Laws, Sandro Santagata, Rameen Beroukhim, Ian F Dunn
PURPOSE: Pituitary adenomas are the second most common primary brain tumor, yet their genetic profiles are incompletely understood. EXPERIMENTAL DESIGN: We performed whole-exome sequencing of 42 pituitary macroadenomas and matched normal DNA. These adenomas included hormonally active and inactive tumors, ones with typical or atypical histology, and ones that were primary or recurrent. RESULTS: We identified mutations, insertions/deletions, and copy number alterations...
October 5, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Yossef Alnasser, Cusi Ferradas, Taryn Clark, Maritza Calderon, Alejandro Gurbillon, Dionicia Gamboa, Uri S McKakpo, Isabella A Quakyi, Kwabena M Bosompem, David J Sullivan, Joseph M Vinetz, Robert H Gilman
Plasmodium vivax is the most prevalent cause of human malaria in the world and can lead to severe disease with high potential for relapse. Its genetic and geographic diversities make it challenging to control. P. vivax is understudied and to achieve control of malaria in endemic areas, a rapid, accurate, and simple diagnostic tool is necessary. In this pilot study, we found that a colorimetric system using AuNPs and MSP10 DNA detection in urine can provide fast, easy, and inexpensive identification of P. vivax...
October 2016: PLoS Neglected Tropical Diseases
Yana Davidov, Bella Ungar, Haggai Bar Yoseph, Dan Carter, Ola Haj-Natour, Miri Yavzori, Yehuda Chowers, Rami Eliakim, Shomron BenHorin, Uri Kopylov
BACKGROUND: The association of infliximab (IFX) trough levels with clinical and endoscopic outcomes in inflammatory bowel disease is well established. However there is scarce data regarding the association of perianal fistula response with IFX. The aim of the study was to establish whether early induction infliximab levels and anti-infliximab antibodies (ATI) are associated with perianal fistula response. METHODS: Consecutive CD patients with perianal fistulae that were treated with IFX between 2008 and 2016 were included in the study...
October 4, 2016: Journal of Crohn's & Colitis
Uri Landes, Alexander Sagie, Ran Kornowski
Sutureless aortic bioprostheses (SAB) are increasingly being used to provide shorter cross-clamp time. Valve-in-valve transcatheter aortic valve replacement (VIV-A) is shown to be effective and safe in the vast majority of patients with degenerated bioprosthetics, yet its' use in SAB failure is infrequent. We present a case of balloon-expandable VIV-A in an 80-year-old woman who suffered severe symptomatic aortic regurgitation in a failed Perceval S 21-mm valve. Computed tomography scan demonstrated a deformed valve...
October 3, 2016: Catheterization and Cardiovascular Interventions
Fouad Brahimi, Mario Maira, Pablo F Barcelona, Alba Galan, Tahar Aboulkassim, Katrina Teske, Mary-Louise Rogers, Lisa Bertram, Jing Wang, Masoud Yousefi, Robert Rush, Marc Fabian, Neil Cashman, H Uri Saragovi
Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce neurotoxic TNF-α; hence resulting in opposing pathways. In mouse and human ALS spinal cord, the reduction of miR-128 that destabilizes TrkC.T1 mRNA results in up-regulated TrkC.T1 and TNF-α in astrocytes. We exploited conformational differences to develop an agonistic mAb 2B7 that selectively activates TrkC-FL, to circumvent TrkC...
2016: PloS One
Yifat Sarda, Elad Bergman, Inbar Hillel, Itzhak Binderman, Uri Nevo
PURPOSE: Osteoporosis is characterized by a decrease in bone mineral density (BMD). A preliminary stage of the disease is progressive bone marrow adiposity, caused by imbalance between osteogenesis and adipogenesis in the marrow. Detection of osteoporosis relies on the quantification of BMD with techniques such as dual-energy X-ray absorptiometry. This work aimed to detect bone marrow changes in an experimental model of osteopenia using a low-field tabletop NMR scanner. METHODS: An experiment was performed on 32 female rats, 3 months old, 16 of which were ovariectomized (OVX) and 16 were sham-operated (sham)...
September 30, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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