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https://www.readbyqxmd.com/read/28820593/structure-of-dynamic-taxol-stabilized-and-gmppcp-stabilized-microtubule
#1
Avi Ginsburg, Asaf Shemesh, Abigail Millgram, Raviv Dharan, Yael Levi-Kalisman, Israel Ringel, Uri Raviv
Microtubule (MT) is made of αβ-tubulin heterodimers that dynamically assemble into a hollow nanotube composed of straight protofilaments. MT dynamics is facilitated by hydrolysis of guanosine-5'-triphosphate (GTP) and can be inhibited by either anticancer agents like taxol or by the non-hydrolyzable GTP analogues like GMPPCP. Using high-resolution synchrotron X-ray scattering, we have measured and analyzed the scattering curves from solutions of dynamic MT (in other words, in the presence of excess GTP and free of dynamic-inhibiting agents) and examined the effect of two MT stabilizers: taxol and GMPPCP...
August 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28811367/amplification-of-local-changes-along-the-timescale-processing-hierarchy
#2
Yaara Yeshurun, Mai Nguyen, Uri Hasson
Small changes in word choice can lead to dramatically different interpretations of narratives. How does the brain accumulate and integrate such local changes to construct unique neural representations for different stories? In this study, we created two distinct narratives by changing only a few words in each sentence (e.g., "he" to "she" or "sobbing" to "laughing") while preserving the grammatical structure across stories. We then measured changes in neural responses between the two stories. We found that differences in neural responses between the two stories gradually increased along the hierarchy of processing timescales...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28810066/-oh-the-places-you-ll-go-by-bringing-developmental-science-into-the-world
#3
Roberta M Golinkoff, Kathy Hirsh-Pasek, Rachel Grob, Mark Schlesinger
Urie Bronfenbrenner and Ernest Boyer argued for leaving the laboratory to conduct rigorous developmental research in the real world where children are found-in the places they go. Contributions to this special issue meet Bronfenbrenner and Boyer's call while at the same time recognizing the continued importance of laboratory research. These articles range from a review of research on the arts to a language intervention in Senegal to large-scale dissemination and intervention projects designed to communicate the best developmental science to families, public agencies, and schools...
August 15, 2017: Child Development
https://www.readbyqxmd.com/read/28808031/changes-in-aggregation-states-of-light-harvesting-complexes-as-a-mechanism-for-modulating-energy-transfer-in-desert-crust-cyanobacteria
#4
Leeat Bar Eyal, Reza Ranjbar Choubeh, Eyal Cohen, Ido Eisenberg, Carmen Tamburu, Márta Dorogi, Renata Ünnep, Marie-Sousai Appavou, Reinat Nevo, Uri Raviv, Ziv Reich, Győző Garab, Herbert van Amerongen, Yossi Paltiel, Nir Keren
In this paper we propose an energy dissipation mechanism that is completely reliant on changes in the aggregation state of the phycobilisome light-harvesting antenna components. All photosynthetic organisms regulate the efficiency of excitation energy transfer (EET) to fit light energy supply to biochemical demands. Not many do this to the extent required of desert crust cyanobacteria. Following predawn dew deposition, they harvest light energy with maximum efficiency until desiccating in the early morning hours...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28805112/casting-doubt-on-the-value-of-assessing-the-cardiac-index-in-pregnancy
#5
Maya Ram, Anat Lavie, Shaul Lev, Yair Blecher, Uri Amikam, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel Many
OBJECTIVES: The objective of this study is to assess the reliability of the cardiac index (CI) in healthy pregnant women at term by investigating the correlation between the cardiac output (CO) and the body surface area (BSA) using a novel non-invasive cardiography technique (NICaS™). METHODS: Sixty-one healthy, normotensive women with a singleton pregnancy at term (≥37 gestational weeks) participated in this prospective observational study between 1/2015 and 6/2015 L...
August 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28798721/the-parkinson-care-advocate-integrating-care-delivery
#6
Leonard L Sokol, Debbie Shapiro, Michael J Young, Adina H Wise, Uri P Hadelsberg, Yakir Kaufman, Alberto J Espay, Aristide Merola
No abstract text is available yet for this article.
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28797546/cell-free-deoxyribonucleic-acid-as-a-prognostic-marker-of-bowel-ischemia-in-patients-with-small-bowel-obstruction
#7
Uri Netz, Zvi Perry, Solly Mizrahi, Boris Kirshtein, David Czeiger, Gilbert Sebbag, Avraham Reshef, Amos Douvdevani
BACKGROUND: Patients with strangulation small bowel obstruction are at a high risk for serious morbidity and mortality due to ischemic bowel. Measuring serum, cell-free deoxyribonucleic acid levels could help recognize early cell death. Our hypothesis was that small bowel ischemia or necrosis is associated with increases in serum cell-free deoxyribonucleic acid and that recovery is associated with a decrease in cell-free deoxyribonucleic acid levels. METHODS: A prospective cohort study in addition to standard treatment of patients admitted with a diagnosis of small bowel obstruction...
August 7, 2017: Surgery
https://www.readbyqxmd.com/read/28796651/ultrasound-assisted-reduction-of-displaced-and-shortened-fractures-by-pediatric-emergency-physicians
#8
Eric Scheier, Uri Balla
Pediatric emergency physicians at Kaplan Medical Center regularly reduce forearm fractures under point-of-care ultrasound guidance in the pediatric emergency department. We present 3 children who arrived at our department with shortened, angulated forearm fractures within the span of a single week. We report on the successful reduction of these fractures under point-of-care ultrasound and on the maintenance of anatomic alignment at follow-up 1 week postreduction.
August 7, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28795772/the-potential-of-the-spectral-water-balance-index-wabi-for-crop-irrigation-scheduling
#9
Tal Rapaport, Uri Hochberg, Amnon Cochavi, Arnon Karnieli, Shimon Rachmilevitch
Hyperspectral sensing can detect slight changes in plant physiology, and may offer a faster and nondestructive alternative for water status monitoring. This premise was tested in the current study using a narrow-band 'water balance index' (WABI), which is based on independent changes in leaf water content (1500 nm) and the efficiency of the nonphotochemical quenching (NPQ) photo-protective mechanism (531 nm). The hydraulic, photo-protective and spectral behaviors of five important crops - grapevine, corn, tomato, pea and sunflower - were evaluated under water deficit conditions in order to associate the differences in stress physiology with WABI suitability...
August 10, 2017: New Phytologist
https://www.readbyqxmd.com/read/28776851/say-a-prayer-for-the-safe-cutting-of-a-child-s-teeth-the-folklore-of-teething
#10
Sarah Malkiel, Michal Eisenstadt, Uri Pollak
No abstract text is available yet for this article.
August 3, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28772125/discovering-event-structure-in-continuous-narrative-perception-and-memory
#11
Christopher Baldassano, Janice Chen, Asieh Zadbood, Jonathan W Pillow, Uri Hasson, Kenneth A Norman
During realistic, continuous perception, humans automatically segment experiences into discrete events. Using a novel model of cortical event dynamics, we investigate how cortical structures generate event representations during narrative perception and how these events are stored to and retrieved from memory. Our data-driven approach allows us to detect event boundaries as shifts between stable patterns of brain activity without relying on stimulus annotations and reveals a nested hierarchy from short events in sensory regions to long events in high-order areas (including angular gyrus and posterior medial cortex), which represent abstract, multimodal situation models...
August 2, 2017: Neuron
https://www.readbyqxmd.com/read/28769825/a-pilot-study-of-possible-easy-to-use-electrophysiological-index-for-early-detection-of-antidepressive-treatment-non-response
#12
Goded Shahaf, Shahak Yariv, Boaz Bloch, Uri Nitzan, Aviv Segev, Alon Reshef, Yuval Bloch
INTRODUCTION: The evaluation of response to pharmacological treatment in MDD requires 4-8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of prime significance. Many studies have demonstrated significant results regarding the ability to use EEG and ERP markers, including attention-associated markers such as P300, for early prediction of response to treatment. But these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28767668/creative-foraging-an-experimental-paradigm-for-studying-exploration-and-discovery
#13
Yuval Hart, Avraham E Mayo, Ruth Mayo, Liron Rozenkrantz, Avichai Tendler, Uri Alon, Lior Noy
Creative exploration is central to science, art and cognitive development. However, research on creative exploration is limited by a lack of high-resolution automated paradigms. To address this, we present such an automated paradigm, the creative foraging game, in which people search for novel and valuable solutions in a large and well-defined space made of all possible shapes made of ten connected squares. Players discovered shape categories such as digits, letters, and airplanes as well as more abstract categories...
2017: PloS One
https://www.readbyqxmd.com/read/28765495/validating-reference-equations-for-impulse-oscillometry-in-healthy-mexican-children
#14
Laura Gochicoa-Rangel, Rodrigo Del Río-Hidalgo, Juana Hernández-Ruiz, Luis Rodríguez-Moreno, David Martínez-Briseño, Uri Mora-Romero, Silvia Cid-Juárez, Cecilia García-Sancho, Luis Torre-Bouscoulet
BACKGROUND: The impulse oscillometry system (IOS) measures the impedance (Z) of the respiratory system, but proper interpretation of its results requires adequate reference values. The objectives of this work were: (1) to validate the reference equations for the IOS published previously by our group and (2) to compare the adjustment of new available reference equations for the IOS from different countries in a sample of healthy children. METHODS: Subjects were healthy 4-15-y-old children from the metropolitan area of Mexico City, who performed an IOS test...
August 1, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28765323/tumor-treating-fields-a-fourth-modality-in-cancer-treatment
#15
Elijah J Mun, Hani M Babiker, Uri Weinberg, Eilon D Kirson, Daniel D Von Hoff
Despite major advances in therapy, cancer continues to be a leading cause of mortality. Additionally, toxicities of traditional therapies pose a significant challenge to tolerability and adherence. TTFields, a noninvasive anticancer treatment modality, utilizes alternating electric fields at specific frequencies and intensities to selectively disrupt mitosis in cancerous cells. TTFields target proteins crucial to the cell cycle, leading to mitotic arrest and apoptosis. TTFields also facilitate an antitumor immune response...
August 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28763428/cmv-infection-in-pediatric-severe-ulcerative-colitis-a-multicenter-study-from-the-pediatric-ibd-porto-group-of-espghan
#16
Shlomi Cohen, Christine Martinez-Vinson, Marina Aloi, Dan Turner, Amit Assa, Lissy de Ridder, Victorien M Wolters, Tim de Meij, Patrizia Alvisi, Jiri Bronsky, Uri Kopylov
BACKGROUND: Data on the clinical course and outcomes of pediatric patients with cytomegalovirus (CMV) infection complicating acute severe ulcerative colitis (ASC) are very limited. The aim of our study was to compare outcomes of children with ASC who were CMV-positive or CMV-negative. METHODS: This was a multicenter retrospective case-controlled study, from centers affiliated with the Pediatric IBD Porto Group of ESPGHAN. We included CMV -positive children hospitalized for ASC and compared their colectomy rate during hospitalization and up to 1 year thereafter, matched with CMV-negative controls...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28763279/effect-of-a-synthetic-feline-facial-pheromone-product-on-stress-scores-and-incidence-of-upper-respiratory-tract-infection-in-shelter-cats
#17
Robin M Chadwin, Melissa J Bain, Philip H Kass
OBJECTIVE To determine whether a synthetic feline facial pheromone product would decrease stress scores and upper respiratory tract infection (URI) incidence in shelter-housed cats. DESIGN Randomized controlled clinical trial. ANIMALS 336 stray, feral, owner-relinquished, or legally impounded cats at 2 animal shelters in northern California. PROCEDURES 5 cat holding rooms (3 at shelter A and 2 at shelter B) were used. A diffuser containing either synthetic pheromone or placebo was randomly assigned to each room, and cats were exposed for a 21-day period...
August 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28762154/the-aortic-bifurcation-angle-as-a-factor-in-application-of-the-outback-for-femoropopliteal-lesions-in-ipsilateral-versus-contralateral-approaches
#18
Daniel Raskin, Boris Khaitovich, Shmuel Balan, Daniel Silverberg, Moshe Halak, Uri Rimon
PURPOSE: To assess the technical success of the Outback reentry device in contralateral versus ipsilateral approaches for femoropopliteal arterial occlusion. MATERIALS AND METHODS: A retrospective review of patients treated for critical limb ischemia (CLI) using the Outback between January 2013 and July 2016 was performed. Age, gender, length and site of the occlusion, approach site, aortic bifurcation angle, and reentry site were recorded. Calcification score was assigned at both aortic bifurcation and reentry site...
July 31, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28759404/upper-respiratory-infections-and-airway-adverse-events-in-pediatric-procedural-sedation
#19
Michael D Mallory, Curtis Travers, Courtney E McCracken, James Hertzog, Joseph P Cravero
BACKGROUND: Upper respiratory infections (URIs) are associated with airway adverse events (AAEs) during general anesthesia. There have been no large studies examining the relationship between URIs and AAEs during pediatric procedural sedation. We hypothesized that there would be a relationship between URI status and AAEs in pediatric procedural sedation. METHODS: We examined prospectively collected data from the Pediatric Sedation Research Consortium database. Specific questions regarding URI status were added to the database to facilitate our analysis...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28754258/viral-minority-variants-in-the-core-promoter-and-precore-region-identified-by-deep-sequencing-are-associated-with-response-to-peginterferon-and-adefovir-in-hbeag-negative-chronic-hepatitis-b-patients
#20
Louis Jansen, Matthijs R A Welkers, Karel A van Dort, R Bart Takkenberg, Uri Lopatin, Hans L Zaaijer, Menno D de Jong, Hendrik W Reesink, Neeltje A Kootstra
BACKGROUND AND AIM: Precore (PC) and basal core promoter (BCP) mutations are associated with responses to interferon-based treatment in HBeAg-positive chronic hepatitis B (CHB) patients. Here, we identify viral minority variants in these regions and assess association with response to peginterferon-alfa (Peg-IFN) and adefovir combination therapy. PATIENTS AND METHODS: Ultra-deep pyrosequencing analysis of the BCP and PC region was performed for 89 CHB patients (42 HBeAg-positive; 47 HBeAg-negative), at baseline and during treatment...
July 25, 2017: Antiviral Research
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