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https://www.readbyqxmd.com/read/29335637/expression-profiling-of-host-and-virus-during-a-coccolithophore-bloom-provides-insights-into-the-role-of-viral-infection-in-promoting-carbon-export
#1
Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
The cosmopolitan coccolithophore Emiliania huxleyi is a unicellular eukaryotic alga that forms vast blooms in the oceans impacting large biogeochemical cycles. These blooms are often terminated due to infection by the large dsDNA virus, E. huxleyi virus (EhV). It was recently established that EhV-induced modulation of E. huxleyi metabolism is a key factor for optimal viral infection cycle. Despite the huge ecological importance of this host-virus interaction, the ability to assess its spatial and temporal dynamics and its possible impact on nutrient fluxes is limited by current approaches that focus on quantification of viral abundance and biodiversity...
January 15, 2018: ISME Journal
https://www.readbyqxmd.com/read/29326989/progressive-calibration-and-averaging-for-tandem-mass-spectrometry-statistical-confidence-estimation-why-settle-for-a-single-decoy
#2
Uri Keich, William Stafford Noble
Estimating the false discovery rate (FDR) among a list of tandem mass spectrum identifications is mostly done through target-decoy competition (TDC). Here we offer two new methods that can use an arbitrarily small number of additional randomly drawn decoy databases to improve TDC. Specifically, "Partial Calibration" utilizes a new meta-scoring scheme that allows us to gradually benefit from the increase in the number of identifications calibration yields and "Averaged TDC" (a-TDC) reduces the liberal bias of TDC for small FDR values and its variability throughout...
May 2017: Research in Computational Molecular Biology: ... Annual International Conference, RECOMB ...: Proceedings
https://www.readbyqxmd.com/read/29325789/long-term-outcomes-following-ileal-pouch-anal-anastomosis-in-patients-with-indeterminate-colitis
#3
Uri Netz, Norman J Galbraith, Stephen O'Brien, Jane Carter, Stephen Manek, Robert E Petras, Susan Galandiuk
BACKGROUND: The advisability of performing ileal pouch-anal anastomosis for patients with indeterminate colitis is debated. Indeterminate colitis is found in up to 15% of inflammatory bowel disease colectomy specimens. We determined long-term outcomes in patients diagnosed with indeterminate colitis undergoing ileal pouch-anal anastomosis. METHODS: Fifty-six patients were included with a mean follow-up of 14 ± 7 years. Long-term behavior was defined based on surgeon assessment as "Crohn disease-like" in patients who subsequently developed clear signs of Crohn disease and as "non-Crohn disease-like...
January 8, 2018: Surgery
https://www.readbyqxmd.com/read/29324905/strains-of-bacterial-species-induce-a-greatly-varied-acute-adaptive-immune-response-the-contribution-of-the-accessory-genome
#4
Uri Sela, Chad W Euler, Joel Correa da Rosa, Vincent A Fischetti
A fundamental question in human susceptibility to bacterial infections is to what extent variability is a function of differences in the pathogen species or in individual humans. To focus on the pathogen species, we compared in the same individual the human adaptive T and B cell immune response to multiple strains of two major human pathogens, Staphylococcus aureus and Streptococcus pyogenes. We found wide variability in the acute adaptive immune response induced by various strains of a species, with a unique combination of activation within the two arms of the adaptive response...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29319496/geographic-variations-in-antibiotic-prescription-for-pediatric-acute-upper-respiratory-tract-infections-in-south-korea
#5
Youn Jung, Hyemin Cho, Eunhee Ji, Eun-Ji Park, Sunmee Jang
OBJECTIVE: This study aimed to investigate the factors affecting the geographic differences in antibiotic prescription rates in pediatric upper respiratory tract infections (URI) patients in South Korea. MATERIALS AND METHODS: We performed a nationwide cross-sectional study using 228 administrative districts of Korea, which are the unit of analysis. Prescription rate of antibiotics, the outcome variable, was measured as the proportion of antibiotic prescription days out of total visit days for the treatment of acute URIs using National Health Insurance Service (NHIS) claims data for 2012...
January 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29316566/double-anterior-stereotactic-cingulotomy-for-intractable-oncological-pain
#6
Ido Strauss, Assaf Berger, Shlomit Ben Moshe, Michal Arad, Uri Hochberg, Tal Gonen, Rotem Tellem
BACKGROUND: Stereotactic anterior cingulotomy has been used in the treatment of patients suffering from refractory oncological pain due to its effects on pain perception. However, the optimal targets as well as suitable candidates and outcome measures have not been well defined. We report our initial experience in the ablation of 2 cingulotomy targets on each side and the use of the Brief Pain Inventory (BPI) as a perioperative assessment tool. METHODS: A retrospective review of all patients who underwent stereotactic anterior cingulotomy in our Department between November 2015 and February 2017 was performed...
January 10, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29316547/o-arm-guided-percutaneous-radiofrequency-cordotomy
#7
Ido Strauss, Assaf Berger, Michal Arad, Uri Hochberg, Rotem Tellem
BACKGROUND: Pain is often one of the most debilitating symptoms in patients with advanced oncological disease. Patients with localized pain due to malignancy refractory to medical treatment can benefit from selective percutaneous cordotomy that disconnects the ascending pain fibers in the spinothalamic tract. OBJECTIVES: Over the past year, we have been performing percutaneous radiofrequency cordotomy with the use of the O-Arm intraoperative imaging system that allows both 2D fluoroscopy and 3D reconstructed computerized tomography imaging...
January 10, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29311597/putative-functional-genes-in-idiopathic-dilated-cardiomyopathy
#8
Nishanth Ulhas Nair, Avinash Das, Uri Amit, Welles Robinson, Seung Gu Park, Mahashweta Basu, Alex Lugo, Jonathan Leor, Eytan Ruppin, Sridhar Hannenhalli
Idiopathic dilated cardiomyopathy (DCM) is a complex disorder with a genetic and an environmental component involving multiple genes, many of which are yet to be discovered. We integrate genetic, epigenetic, transcriptomic, phenotypic, and evolutionary features into a method - Hridaya, to infer putative functional genes underlying DCM in a genome-wide fashion, using 213 human heart genomes and transcriptomes. Many genes identified by Hridaya are experimentally shown to cause cardiac complications. We validate the top predicted genes, via five different genome-wide analyses: First, the predicted genes are associated with cardiovascular functions...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306776/histological-and-chemical-analyses-of-mesiodens-development-and-mineralization
#9
Awady Muhamad, Moskovitz Moti, Cohen Ornit, Zilberman Uri
OBJECTIVE: This study aimed to compare the developmental timing and mineralization quality of mesiodentes, i.e., supernumerary teeth located mainly in the midline of the maxilla between the central incisors, with the developmental timing and mineralization quality of permanent and primary central incisors. DESIGN: Sixteen mesiodentes, nine permanent and seven primary central incisors were collected. The location of the neonatal line was determined using a light microscope at 10× or 20× enlargements...
December 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29302839/in-vitro-exposure-of-nasal-epithelial-cells-to-atmospheric-dust
#10
David Elad, Uri Zaretsky, Sharon Avraham, Ruthie Gotlieb, Michael Wolf, Itzhak Katra, Shlomo Sarig, Eli Zaady
Dust storms are common phenomena in many parts of the world, and significantly increase the level of atmospheric particulate matter (PM). The soil-derived dust is a mixture of organic and inorganic particles and even remnants of pesticides from agricultural areas nearby. The risk of human exposure to atmospheric dust is well documented, but very little is known on the impact of inhaled PM on the biological lining of the nasal cavity, which is the natural filter between the external environment and the respiratory tract...
January 4, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29301767/avoiding-big-bubble-complications-outcomes-of-layer-by-layer-deep-anterior-lamellar-keratoplasty-in-children
#11
Uri Elbaz, Caitriona Kirwan, Carl Shen, Asim Ali
BACKGROUND/AIMS: To describe the visual and clinical outcomes of manual layer-by-layer deep anterior lamellar keratoplasty (DALK) in a paediatric population. METHODS: The charts of all children who underwent DALK surgery between January 2007 and January 2015 were reviewed retrospectively. Data collected included preoperative and postoperative spectacle-corrected distance visual acuity (CDVA), intraoperative and postoperative complications including graft rejection and failure...
January 4, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29299824/the-value-of-synchro-cystourethrometry-for-evaluating-the-relationship-between-urethral-instability-and-overactive-bladder
#12
Chaoyang Hua, Yibo Wen, Yan Zhang, Quande Feng, Xiangfei He, Yunlong Li, Junwei Wu, Jinjin Feng, Stuart B Bauer, Jianguo Wen
PURPOSE: To investigate the correlation between urethral instability (URI) and overactive bladder (OAB) in children. METHODS: We retrospectively investigated 126 children with OAB and 36 children without OAB using synchro-cystourethrometry. The prevalence of detrusor overactivity (DO) and URI, and the diagnostic sensitivity of DO alone and DO combined with URI, was compared. The OAB children with URI voluntarily received transcutaneous electrical pudendal nerve stimulation with anisodamine (stimulation group, SG) or anisodamine alone (non-stimulation group, NSG)...
January 3, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29295649/is-bone-marrow-examination-always-necessary-to-establish-the-diagnosis-of-myelodysplastic-syndromes-a-proposed-non-invasive-diagnostic-model
#13
Howard S Oster, Gal Carmi, Alex Kolomansky, Erel Joffe, Irit Kaye, Ilya Kirgner, Uri Greenbaum, Doron Comaneshter, Moshe Mittelman
A non-invasive myelodysplastic syndromes (MDS) diagnostic model would allow for care while avoiding invasive bone marrow examinations (BME). BME-established MDS patients were compared to non-MDS (BME-excluded) patients. Variables (gender, age, hemoglobin (Hb), mean red blood cell corpuscular volume (MCV), platelet (PLT), and white blood cell (WBC)) were combined with multivariate logistic regression; a probability score (Y) was calculated. MDS (n = 48) and non-MDS (n = 63) patients were used to establish the model...
January 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29287715/a-case-of-extensive-diaphragmatic-endometriosis-diagnosed-after-liver-retraction
#14
Uri Pinchas Dior, Martin Healey, Claudia Cheng
No abstract text is available yet for this article.
December 26, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29284495/tumor-treating-fields-ttfields-delay-dna-damage-repair-following-radiation-treatment-of-glioma-cells
#15
Moshe Giladi, Mijal Munster, Rosa S Schneiderman, Tali Voloshin, Yaara Porat, Roni Blat, Katarzyna Zielinska-Chomej, Petra Hååg, Ze'ev Bomzon, Eilon D Kirson, Uri Weinberg, Kristina Viktorsson, Rolf Lewensohn, Yoram Palti
BACKGROUND: Tumor Treating Fields (TTFields) are an anti-neoplastic treatment modality delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. A Phase 3 clinical trial has demonstrated the effectiveness of continuous TTFields application in patients with glioblastoma during maintenance treatment with Temozolomide. The goal of this study was to evaluate the efficacy of combining TTFields with radiation treatment (RT) in glioma cells...
December 29, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29282994/hierarchical-clustering-analysis-framework-of-mutually-exclusive-crash-causation-parameters-for-regional-road-safety-strategies
#16
Avijit Maji, Nagendra R Velaga, Yohan Urie
Hierarchical clustering analysis framework is developed to identify benchmark and critical regions for effective road safety strategies. The regions are grouped based on agglomeration coefficient of mutually exclusive crash causation parameters. Subsequently, regions from groups with lower than a threshold index value are selected as benchmark for the poorly performing critical counterparts. Euclidean distance-based Ward's, median and centroid clustering techniques are explored through a case study of Indian states and Union Territories...
December 28, 2017: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29276769/low-incidence-of-opportunistic-infections-in-lupus-patients-treated-with-cyclophosphamide-and-steroids-in-a-tertiary-care-setting
#17
Shubhasree Banerjee, Ann Biehl, Maryam Ghaderi-Yeganeh, Zerai Manna, Sarfaraz Hasni
Background: Infection is common cause of morbidity and mortality in systemic lupus erythematosus (SLE). Our objective was to determine incidence and types of infections, particularly opportunistic infections, in SLE patients receiving cyclophosphamide, and to identify contribution of variables like demographics, steroid, other immunosuppressives, white blood cell and absolute neutrophil count to infection risk. Patients and Methods: We did retrospective chart review of SLE patients in our institute over last 10 years, who received minimum six cyclophosphamide infusions...
March 2017: Medical Research Archives
https://www.readbyqxmd.com/read/29273206/cardiovascular-health-and-cognitive-decline-2-decades-later-in-men-with-preexisting-coronary-artery-disease
#18
Miri Lutski, Galit Weinstein, Uri Goldbourt, David Tanne
Cardiovascular health (CVH) factors are associated with lower risk of cardiovascular disease, stroke, and mortality. We investigated the association between a modified CVH metrics score and change in cognitive functions 2 decades later in patients with pre-existing coronary artery disease. A subset of 200 men (mean age at baseline 57.3 ± 6.3 years) who previously participated in a secondary prevention trial (1990 to 1997) underwent cognitive evaluation 14.6 ± 1.9 years after baseline (mean age 72...
November 23, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29260225/effect-of-tumor-treating-fields-plus-maintenance-temozolomide-vs-maintenance-temozolomide-alone-on-survival-in-patients-with-glioblastoma-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
Roger Stupp, Sophie Taillibert, Andrew Kanner, William Read, David M Steinberg, Benoit Lhermitte, Steven Toms, Ahmed Idbaih, Manmeet S Ahluwalia, Karen Fink, Francesco Di Meco, Frank Lieberman, Jay-Jiguang Zhu, Giuseppe Stragliotto, David D Tran, Steven Brem, Andreas F Hottinger, Eilon D Kirson, Gitit Lavy-Shahaf, Uri Weinberg, Chae-Yong Kim, Sun-Ha Paek, Garth Nicholas, Jordi Burna, Hal Hirte, Michael Weller, Yoram Palti, Monika E Hegi, Zvi Ram
Importance: Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor. Objective: To investigate whether TTFields improves progression-free and overall survival of patients with glioblastoma, a fatal disease that commonly recurs at the initial tumor site or in the central nervous system. Design, Setting, and Participants: In this randomized, open-label trial, 695 patients with glioblastoma whose tumor was resected or biopsied and had completed concomitant radiochemotherapy (median time from diagnosis to randomization, 3...
December 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29260103/crystalline-lens-dislocation-secondary-to-bacterial-endogenous-endophthalmitis
#20
Amit Sangave, Rahul Komati, Allison Weinmann, Linoj Samuel, Uday Desai
Purpose: To present an unusual case of endogenous endophthalmitis secondary to Group A streptococcus (GAS) that resulted in dislocation of the crystalline lens. Observations: An immunocompetent 51-year-old man presented to the emergency room (ER) with upper respiratory infection (URI) symptoms and painful right eye. He was diagnosed with URI and viral conjunctivitis and discharged on oral azithromycin and polytrim eyedrops. He returned to the ER 30 h later with sepsis and findings consistent with endophthalmitis, including light perception only vision...
September 2017: American Journal of Ophthalmology Case Reports
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