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https://www.readbyqxmd.com/read/27905297/altered-thermoregulatory-responses-in-heart-failure-patients-exercising-in-the-heat
#1
Bryce N Balmain, Ollie Jay, Surendran Sabapathy, Danielle Royston, Glenn M Stewart, Rohan Jayasinghe, Norman R Morris
Heart failure (HF) patients appear to exhibit impaired thermoregulatory capacity during passive heating, as evidenced by diminished vascular conductance. Although some preliminary studies have described the thermoregulatory response to passive heating in HF, responses during exercise in the heat remain to be described. Therefore, the aim of this study was to compare thermoregulatory responses in HF and controls (CON) during exercise in the heat. Ten HF (NYHA classes I-II) and eight CON were included. Core temperature (Tc), skin temperature (Tsk), and cutaneous vascular conductance (CVC) were assessed at rest and during 1 h of exercise at 60% of maximal oxygen uptake...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27889388/cellular-aging-contributes-to-failure-of-cold-induced-beige-adipocyte-formation-in-old-mice-and-humans
#2
Daniel C Berry, Yuwei Jiang, Robert W Arpke, Elizabeth L Close, Aki Uchida, David Reading, Eric D Berglund, Michael Kyba, Jonathan M Graff
Cold temperatures induce progenitor cells within white adipose tissue to form beige adipocytes that burn energy and generate heat; this is a potential anti-diabesity therapy. However, the potential to form cold-induced beige adipocytes declines with age. This creates a clinical roadblock to potential therapeutic use in older individuals, who constitute a large percentage of the obesity epidemic. Here we show that aging murine and human beige progenitor cells display a cellular aging, senescence-like phenotype that accounts for their age-dependent failure...
November 21, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27885739/analysis-of-factors-affecting-outcome-of-ultrasound-guided-radiofrequency-heat-ablation-for-treatment-of-primary-hyperparathyroidism-in-dogs
#3
Daniel Bucy, Rachel Pollard, Richard Nelson
Radiofrequency (RF) parathyroid ablation is a noninvasive treatment for hyperparathyroidism in dogs. There are no published data assessing factors associated with RF parathyroid ablation success or failure in order to guide patient selection and improve outcome. The purpose of this retrospective analytical study was to determine whether imaging findings, biochemical data, or concurrent diseases were associated with RF heat ablation treatment failure. For inclusion in the study, dogs must have had a clinical diagnosis of primary hyperparathyroidism, undergone cervical ultrasound and RF ablation of abnormal parathyroid tissue, and must have had at least 3 months of follow-up information available following the date of ultrasound-guided parathyroid ablation...
November 24, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27879385/fio2-in-an-adult-model-simulating-high-flow-nasal-cannula-therapy
#4
Yusuke Chikata, Mutsuo Onodera, Jun Oto, Masaji Nishimura
BACKGROUND: High-flow nasal cannula therapy (HFNC) is widely used for patients with acute respiratory failure. HFNC has a number of physiological effects. Although FIO2 is considered to be constant, because HFNC is an open system, FIO2 varies according to inspiratory flow, tidal volume (VT), and HFNC gas flow. We investigated the influence of HFNC gas flow and other respiratory parameters on FIO2 during HFNC. METHODS: We evaluated an HFNC system and, for comparison, a conventional oxygen therapy system...
November 22, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27832001/scaling-the-low-shear-pulsatile-torvad-for-pediatric-heart-failure
#5
Jeffrey R Gohean, Erik R Larson, Brian H Hsi, Mark Kurusz, Richard W Smalling, Raul G Longoria
This article provides an overview of the design challenges associated with scaling the low-shear pulsatile TORVAD ventricular assist device (VAD) for treating pediatric heart failure. A cardiovascular system model was used to determine that a 15 ml stroke volume device with a maximum flow rate of 4 L/min can provide full support to pediatric patients with body surface areas between 0.6 to 1.5 m2. Low shear stress in the blood is preserved as the device is scaled down and remains at least two orders of magnitude less than continuous flow VADs...
November 9, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27829769/comparative-evaluation-of-shear-bond-strength-of-two-different-chairside-soft-liners-to-heat-processed-acrylic-denture-base-resin-an-in-vitro-study
#6
N Rajaganesh, S Sabarinathan, N S Azhagarasan, Chitra Shankar, Jaya Krishnakumar, S Swathi
BACKGROUND: Chairside softliners are used more frequently than is reported and studies regarding the bond strength of chairside softliners to heat-polymerized denture base resin are few and limited. Hence, this study was conducted to comparatively evaluate the shear bond strength of two chairside soft relining materials viz., autopolymerizing plasticized acrylic resin liner and a silicone-based liner bonded to heat polymerized polymethyl methacrylate denture base resin and to analyze the mode of interfacial bond failure...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27826463/thermal-injury-to-reconstructed-breasts-from-commonly-used-warming-devices-a-risk-for-reconstructive-failure
#7
Heather R Faulkner, Amy S Colwell, Eric C Liao, Jonathan M Winograd, William G Austen
BACKGROUND: Sensation is decreased or absent after breast reconstruction. This leaves reconstructed breasts vulnerable to injury from common household thermal sources such as heating pads and hot water bottles. We sought to categorize these injuries, provide a treatment plan, and prevent these injuries in the future. METHODS: A retrospective review of patients who had sustained burns to reconstructed breasts with household devices was performed at a single institution...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27826324/respiratory-support-with-heated-humidified-high-flow-nasal-cannula-in-preterm-infants
#8
REVIEW
Ga Won Jeon
The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which is the most recently introduced NIV mode for respiratory support in preterm infants, is rapidly increasing in many neonatal intensive care units due to the technical ease of use without sealing, and the attending physician's preference compared to other NIV modes...
October 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27822041/influence-of-incorporation-of-zro2-nanoparticles-on-the-repair-strength-of-polymethyl-methacrylate-denture-bases
#9
Mohammed M Gad, Ahmed Rahoma, Ahmad M Al-Thobity, Aws S ArRejaie
BACKGROUND: Repeated fracture of the denture base is a common problem in prosthodontics, and it represents a nuisance and a time sink for the clinician. Therefore, the possibility of increasing repair strength using new reinforcement materials is of great interest to prosthodontists. AIM OF THE STUDY: This study aimed to evaluate the effects of incorporation of zirconia nanoparticles (nano-ZrO2) on the flexural strength and impact strength of repaired polymethyl methacrylate (PMMA) denture bases...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27786541/postexercise-cold-water-immersion-improves-intermittent-high-intensity-exercise-performance-in-normothermia
#10
Avina McCarthy, James Mulligan, Mikel Egaña
A brief cold water immersion between 2 continuous high-intensity exercise bouts improves the performance of the latter compared with passive recovery in the heat. We investigated if this effect is apparent in normothermic conditions (∼19 °C), employing an intermittent high-intensity exercise designed to reflect the work performed at the high-intensity domain in team sports. Fifteen young active men completed 2 exhaustive cycling protocols (Ex1 and Ex2: 12 min at 85% ventilatory threshold (VT) and then an intermittent exercise alternating 30-s at 40% peak power (Ppeak) and 30 s at 90% Ppeak to exhaustion) separated by 15 min of (i) passive rest, (ii) 5-min cold-water immersion at 8 °C, and (iii) 10-min cold-water immersion at 8 °C...
July 25, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27776396/venous-thromboembolism-following-dantrolene-treatment-for-neuroleptic-malignant-syndrome
#11
Po-Hao Chen, Hsien-Yuan Lane, Chieh-Hsin Lin
Neuroleptic malignant syndrome (NMS) is one of the most severe iatrogenic emergencies in clinical service. The symptoms including sudden consciousness change, critical temperature elevation and electrolytes imbalance followed by mutli-organ system failure were common in NMS. In addition to aggressive interventions with intravenous fluid resuscitation and antipyretics, several antidotes have been suggested to prevent further progression of the muscle damage. Dantrolene has been reported to be one of the most effective treatments for NMS...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27773575/efficacy-of-a-newly-modified-technique-for-distal-limited-open-stenting-in-octogenarians-with-aortic-arch-aneurysm
#12
Mitsumasa Hata, Yukihiko Orime, Shinji Wakui, Tetsuya Nakamura, Rei Hinoura, Atsushi Harada, Kenji Akiyama
OBJECTIVE: We assessed the efficacy of distal limited open stenting procedure in octogenarians with distal aortic arch aneurysm. METHODS: During the last 5 years, 24 patients underwent distal limited open stenting. Mean patient age was 81.6 ± 2.5 years, ranging from 80 to 90 years. The hemicircumference of the anterior surface of the arch around the left common carotid artery was obliquely incised, and a J-Graft Open Stent (Japan Lifeline Co, Ltd, Tokyo, Japan) was inserted into the descending aorta...
September 24, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27768727/addition-of-alanyl-glutamine-to-dialysis-fluid-restores-peritoneal-cellular-stress-responses-a-first-in-man-trial
#13
Klaus Kratochwill, Michael Boehm, Rebecca Herzog, Katharina Gruber, Anton Michael Lichtenauer, Lilian Kuster, Dagmar Csaicsich, Andreas Gleiss, Seth L Alper, Christoph Aufricht, Andreas Vychytil
BACKGROUND: Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, potentially due to peritoneal glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects of alanyl-glutamine (AlaGln) addition to glucose-based PDF. METHODS: In a prospective randomized cross-over design, 20 stable PD outpatients underwent paired peritoneal equilibration tests 4 weeks apart, using conventional acidic, single chamber 3...
2016: PloS One
https://www.readbyqxmd.com/read/27760282/heated-insufflation-with-or-without-humidification-for-laparoscopic-abdominal-surgery
#14
REVIEW
Daniel W Birch, Jerry T Dang, Noah J Switzer, Namdar Manouchehri, Xinzhe Shi, Ghassan Hadi, Shahzeer Karmali
BACKGROUND: Intraoperative hypothermia during both open and laparoscopic abdominal surgery may be associated with adverse events. For laparoscopic abdominal surgery, the use of heated insufflation systems for establishing pneumoperitoneum has been described to prevent hypothermia. Humidification of the insufflated gas is also possible. Past studies on heated insufflation have shown inconclusive results with regards to maintenance of core temperature and reduction of postoperative pain and recovery times...
October 19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27754056/os-15-04-mineralocorticoid-receptor-antagonists-target-endogenous-repressor-of-hypertrophy
#15
Anastasia Mihailidou, Anthony Ashton
OBJECTIVE: Myocardial infarction (MI) continues to be a major burden of disease, despite rapid reperfusion interventions. Reperfusion of ischemic hearts (reperfusion injury) induces free radical generation, activation of early stress responses and apoptosis, which contributes to ventricular remodeling and dysfunction, which may lead to developing heart failure. Mineralocorticoid receptor (MR) antagonists have been shown clinically to reduce blood pressure, particularly in resistant hypertension, and substantially increase survival in heart failure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27750047/bgp-15-improves-aspects-of-the-dystrophic-pathology-in-mdx-and-dko-mice-with-differing-efficacies-in-heart-and-skeletal-muscle
#16
Tahnee L Kennedy, Kristy Swiderski, Kate T Murphy, Stefan M Gehrig, Claire L Curl, Chanchal Chandramouli, Mark A Febbraio, Lea M D Delbridge, René Koopman, Gordon S Lynch
Duchenne muscular dystrophy is a severe and progressive striated muscle wasting disorder that leads to premature death from respiratory and/or cardiac failure. We have previously shown that treatment of young dystrophic mdx and dystrophin/utrophin null (dko) mice with BGP-15, a coinducer of heat shock protein 72, ameliorated the dystrophic pathology. We therefore tested the hypothesis that later-stage BGP-15 treatment would similarly benefit older mdx and dko mice when the dystrophic pathology was already well established...
October 14, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27747826/seasonal-and-geographic-variation-in-adverse-event-reporting
#17
Osvaldo Marrero, Eric Y Hung, Manfred Hauben
BACKGROUND: Many illnesses demonstrate seasonal and geographic variations. Pharmacovigilance is unique among public health surveillance systems in terms of the clinical diversity of the events under surveillance. Since many pharmacovigilance signal detection methodologies are geared towards looking for increased frequency of spontaneous adverse drug event (ADE) reporting over variable time frames, seasonality of ADEs may have implications for signal detection. OBJECTIVE: The aim of this study was to investigate whether a set of illnesses that might be expected to display seasonality in general, did so when spontaneously reported as ADEs...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27743670/short-communication-the-effect-of-raw-milk-cooling-on-sensory-perception-and-shelf-life-of-high-temperature-short-time-htst-pasteurized-skim-milk
#18
A P Lee, D M Barbano, M A Drake
The cooling rate of raw milk may influence sensory properties and pasteurized shelf life. Under the Pasteurized Milk Ordinance for grade A milk, raw milk may be cooled instantaneously by on-farm heat exchangers but is also acceptable if "cooled to 10°C or less within four (4) hours of the commencement of the first milking." The objective of this study was to determine the effect of raw milk cooling on consumer perception and shelf life. Raw milk (18-21°C) was obtained and transported within 1 h of milking to North Carolina State University (Raleigh)...
October 13, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27737279/exertional-heat-stroke-and-american-football-what-the-team-physician-needs-to-know
#19
Jillian E Sylvester, Luke N Belval, Douglas J Casa, Francis G O'Connor
Football is recognized as a leading contributor to sports injury secondary to the contact collision nature of the endeavor. While direct deaths from head and spine injury remain a significant contributor to the number of catastrophic injuries, indirect deaths (systemic failure) predominate. Exertional heat stroke has emerged as one of the leading indirect causes of death in high school and collegiate football. This review details for the team physician the unique challenge of exercising in the heat to the football player, and the prevention, diagnosis, management, and return-to-play issues pertinent to exertional heat illnesses...
September 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27736717/wear-resistance-and-compression-strength-of-ceramics-tested-in-fluoride-environments
#20
Guilherme Teixeira Theodoro, Lívia Fiorin, Izabela Cristina Maurício Moris, Renata Cristina Silveira Rodrigues, Ricardo Faria Ribeiro, Adriana Cláudia Lapria Faria
Dental ceramics have been widely used because of aesthetic, but wear is still questioned. There are relates that ceramic surface is prone to degradation by acidulated fluoride, that can increase wear rates. The aim of this study was to evaluate the effect of neutral and acidulated fluoride gel, used as preventive agents for professional use, at wear and compression strength of dental ceramics IPS e.max ZirPress (ZIR), IPS Empress Esthetic (EMP) e IPS Inline POM (POM). For this, 30 crowns and 30 disks were obtained by heat-pressing...
September 28, 2016: Journal of the Mechanical Behavior of Biomedical Materials
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