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https://www.readbyqxmd.com/read/29777391/shaping-ability-of-reciprocating-single-file-systems-in-severely-curved-canals-waveone-and-reciproc-versus-waveone-gold-and-reciproc-blue
#1
Sebastian Bürklein, Stefanie Flüch, Edgar Schäfer
The aim was to compare the canal straightening of M-wire [Reciproc (VDW, Munich, Germany) and WaveOne (Dentsply Maillefer, Ballaigues, Switzerland)] and gold- and blue-wire heat-treated [Reciproc blue (VDW) and WaveOne Gold (Dentsply Maillefer)] instruments in severely curved root canals. A total of 80 root canals in extracted human teeth with angles of curvatures ranging between 25° and 35° and radii ranging between 3.1 and 8.5 mm were divided into four groups (n = 20). Based on radiographs taken prior to instrumentation, the groups were balanced with respect to the angle and the radius of canal curvature (P = 1...
May 18, 2018: Odontology
https://www.readbyqxmd.com/read/29773884/pathologic-features-and-expression-of-heat-shock-protein-47-in-the-nasal-mucosa-and-lacrimal-sac-does-it-influence-the-surgical-outcome-of-endoscopic-endonasal-dacryocystorhinostomy
#2
Jinhwan Park, Joonsik Lee, Sehyun Baek
PURPOSE: To correlate the pathologic features and heat shock protein 47 (HSP47) expression in the nasal mucosa and lacrimal sac with the surgical outcomes of endoscopic endonasal dacryocystorhinostomy (EDCR). METHODS: Specimens of the nasal mucosa and lacrimal sac over the rhinostomy site were collected during the operation. Haematoxylin-eosin and immunohistochemical staining were performed to determine the pathologic features (inflammation, fibrosis, squamous metaplasia) and the expression of HSP47 in the epithelium and sub-epithelial glands of the nasal mucosa and lacrimal sac...
May 18, 2018: Eye
https://www.readbyqxmd.com/read/29770776/in-situ-transmission-electron-microscopy-of-transistor-operation-and-failure
#3
Baoming Wang, M Zahabul Islam, M Aman Haque, Kelson Chabak, Michael Snure, Eric Heller, Nicholas Robert Glavin
Microscopy is typically used as a post-mortem analytical tool in performance and reliability studies on nanoscale materials and devices. In this study, we demonstrate real-time microscopy of operation and failure of AlGaN/GaN high electron mobility transistors inside the transmission electron microscope (TEM). Loading till failure was performed on the electron transparent transistors to visualize the failure mechanisms caused by self heating. At lower drain voltages, thermo-mechanical stresses induce irreversible microstructural deformation, mostly along the AlGaN/GaN interface, to initiate the damage process...
May 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29765904/cyclic-fatigue-resistance-torsional-resistance-and-metallurgical-characteristics-of-m3-rotary-and-m3-pro-gold-niti-files
#4
Eugenio Pedullà, Fabio Lo Savio, Giusy Rita Maria La Rosa, Gabriele Miccoli, Elena Bruno, Silvia Rapisarda, Seok Woo Chang, Ernesto Rapisarda, Guido La Rosa, Gianluca Gambarini, Luca Testarelli
Objectives: To evaluate the mechanical properties and metallurgical characteristics of the M3 Rotary and M3 Pro Gold files (United Dental). Materials and Methods: One hundred and sixty new M3 Rotary and M3 Pro Gold files (sizes 20/0.04 and 25/0.04) were used. Torque and angle of rotation at failure ( n = 20) were measured according to ISO 3630-1. Cyclic fatigue resistance was tested by measuring the number of cycles to failure in an artificial stainless steel canal (60° angle of curvature and a 5-mm radius)...
May 2018: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29764147/the-strengths-and-limitations-of-effective-centroid-force-models-explored-by-studying-isotopic-effects-in-liquid-water
#5
Ying Yuan, Jicun Li, Xin-Zheng Li, Feng Wang
The development of effective centroid potentials (ECPs) is explored with both the constrained-centroid and quasi-adiabatic force matching using liquid water as a test system. A trajectory integrated with the ECP is free of statistical noises that would be introduced when the centroid potential is approximated on the fly with a finite number of beads. With the reduced cost of ECP, challenging experimental properties can be studied in the spirit of centroid molecular dynamics. The experimental number density of H2 O is 0...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29761889/a-novel-human-s10f-hsp20-mutation-induces-lethal-peripartum-cardiomyopathy
#6
Guan-Sheng Liu, George Gardner, George Adly, Min Jiang, Wen-Feng Cai, Chi Keung Lam, Fawzi Alogaili, Nathan Robbins, Jack Rubinstein, Evangelia G Kranias
Heat shock protein 20 (Hsp20) has been shown to be a critical regulator of cardiomyocyte survival upon cardiac stress. In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy. Previous findings showed that cardiac-specific overexpression of this mutant were associated with reduced autophagy, left ventricular dysfunction and early death in male mice. However, this study indicates that females have normal function with no alterations in autophagy but died within a week after 1-4 pregnancies...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29755052/lessons-learned-from-data-collection-as-health-screening-in-underserved-farmworker-communities
#7
Joan Flocks, J Antonio Tovar, Eugenia Economos, Valerie Vi Thien Mac, Abby Mutic, Katherine Peterman, Linda McCauley
BACKGROUND: Girasoles is an academic-community partnership investigating heat-related illness (HRI) among farm-workers. An unexpected outcome is health screening and intervention for participants without access to health care. OBJECTIVES: We present a case of renal failure in a farmworker, detected during data collection, to illustrate how academic-community collaboration can result in clinical benefits for study participants. METHODS: Girasoles is examining physiologic responses to heat stress, associated vulnerability factors, and HRI symptoms...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29748348/association-of-ambient-particulate-matter-with-heart-failure-incidence-and-all-cause-readmissions-in-tasmania-an-observational-study
#8
Quan L Huynh, Christopher Leigh Blizzard, Thomas H Marwick, Kazuaki Negishi
OBJECTIVES: We sought to investigate the relationship between air quality and heart failure (HF) incidence and rehospitalisation to elucidate whether there is a threshold in this relationship and whether this relationship differs for HF incidence and rehospitalisation. METHODS: This retrospective observational study was performed in an Australian state-wide setting, where air pollution is mainly associated with wood-burning for winter heating. Data included all 1246 patients with a first-ever HF hospitalisation and their 3011 subsequent all-cause readmissions during 2009-2012...
May 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29741175/rapid-and-sensitive-detection-of-viral-nucleic-acids-using-silicon-microchips
#9
Laura Powell, Rodrigo Sergio Wiederkehr, Paige Damascus, Maarten Fauvart, Federico Buja, Tim Stakenborg, Stuart C Ray, Paolo Fiorini, William O Osburn
Clinical laboratory-based nucleic acid amplification tests (NAT) play an important role in diagnosing viral infections. However, laboratory infrastructure requirements and their failure to diagnose at the point-of-need (PON) limit their clinical utility in both resource-rich and -limited clinical settings. The development of fast and sensitive PON viral NAT may overcome these limitations. The scalability of silicon microchip manufacturing combined with advances in silicon microfluidics present an opportunity for development of rapid and sensitive PON NAT on silicon microchips...
May 9, 2018: Analyst
https://www.readbyqxmd.com/read/29739860/predicted-glycerol-3-phosphate-dehydrogenase-homologs-and-the-glycerol-kinase-glca-coordinately-adapt-to-various-carbon-sources-and-osmotic-stress-in-aspergillus-fumigatus
#10
Chi Zhang, Xiuhua Meng, Huiyu Gu, Zhihua Ma, Ling Lu
Glycerol plays an important role in the adaptation of fungi to various microenvironments and stressors, including heat shock, anoxic conditions and osmotic stress. Glycerol 3-phosphate dehydrogenase (G3PDH) is able to catalyze dihydroxyacetone phosphate to glycerol 3-phosphate (G3P), which is subsequently dephosphorylated into glycerol. However, current knowledge about the functions of G3PDH homologs in glycerol biosynthesis in Aspergillus fumigatus is limited. Here, we show that the A. fumigatus G3PDH gene, gfdA, is crucial for normal colony growth in glucose media under both normoxic and hypoxic conditions...
May 8, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29736270/fiv-vaccine-with-receptor-epitopes-results-in-neutralizing-antibodies-but-does-not-confer-resistance-to-challenge
#11
Craig Miller, Mauren Emanuelli, Elizabeth Fink, Esther Musselman, Ryan Mackie, Ryan Troyer, John Elder, Sue VandeWoude
Feline immunodeficiency virus (FIV) is the feline analogue to human immunodeficiency virus (HIV) and utilizes parallel modes of receptor-mediated entry. The FIV surface glycoprotein (SU) is an important target for induction of neutralizing antibodies, and autoantibodies to the FIV binding receptor (CD134) block infection ex vivo; thus highlighting the potential for immunotherapies which utilize anti-receptor antibodies to block viral infection. To determine whether vaccination with CD134-SU complexes could induce protection against FIV infection, cats ( n  = 5 per group) were immunized with soluble CD134, recombinant FIV-SU protein, and/or CD134+SU complexes...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29697388/-transformation-of-myasthenia-gravis-into-amyotrophic-lateral-sclerosis-or-their-concomitance-case-review
#12
N Kvirkvelia, R Shakarishvili, T Kanashvili
The authors present a case of 75-year-old male patient with typical clinical and electroneuromyographic signs of Amyotrophic Lateral Sclerosis (ALS), manifested in 4 years after a diagnosis of generalized Myasthenia Gravis (MG) had been made. The aim of the article is to assess the possibility of pathogenetic integrated comorbidity of MG and ALS, which may have resulted from a common aberrant immune process and to emphasize the importance of detailed clinical analysis and adequate diagnostic methods essential for correct diagnosis and treatment...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29694982/ucp3-ablation-exacerbates-high-salt-induced-cardiac-hypertrophy-and-cardiac-dysfunction
#13
Hongmei Lang, Yang Xiang, Zhihua Ai, Zhiqing You, Xiaolan Jin, Yong Wan, Yongjian Yang
BACKGROUND/AIMS: Excessive salt intake and left ventricular hypertrophy (LVH) are both critical for the development of hypertension and heart failure. The uncoupling protein 3 (UCP3) plays a cardio-protective role in early heart failure development. However, the potential role for UCP3 in salt intake and LVH is unclear. METHODS: UCP3-/- and C57BL/6 mice were placed on either a normal-salt (NS, 0.5%) or a high-salt (HS, 8%) diet for 24 weeks. The cardiac function, endurance capacity, energy expenditure, and mitochondrial functional capacity were measured in each group...
April 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29694186/self-heating-dark-matter-via-semiannihilation
#14
Ayuki Kamada, Hee Jung Kim, Hyungjin Kim, Toyokazu Sekiguchi
The freeze-out of dark matter (DM) depends on the evolution of the DM temperature. The DM temperature does not have to follow the standard model one, when the elastic scattering is not sufficient to maintain the kinetic equilibrium. We study the temperature evolution of the semiannihilating DM, where a pair of the DM particles annihilate into one DM particle and another particle coupled to the standard model sector. We find that the kinetic equilibrium is maintained solely via semiannihilation until the last stage of the freeze-out...
March 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29678661/role-of-heat-shock-transcription-factor-1-hsf1-upregulated-macrophage-in-ameliorating-pressure-overload-induced-heart-failure-in-mice
#15
Peizhao Du, Yaowei Chang, Fangjie Dai, Chunyan Wei, Qi Zhang, Jiming Li
In order to explore the role of macrophages in HSF1-mediated alleviation of heart failure, mice model of pressure overload-induced heart failure was established using transverse aortic constriction (TAC). Changes in cardiac function and morphology were studied in TAC and SHAM groups using ultrasonic device, tissue staining, electron microscopy, real-time quantitative polymerase chain reaction (RT-QPCR), and Western blotting. We found that mice in the TAC group showed evidence of impaired cardiac function and aggravation of fibrosis on ultrasonic and histopathological examination when compared to those in the SHAM group...
April 17, 2018: Gene
https://www.readbyqxmd.com/read/29656487/experimental-research-requires-valid-and-sensitive-measures-of-alcohol-intake-and-this-is-a-step-in-the-right-direction-commentary-on-leeman-et-al-2018
#16
Matt Field, Andrew Jones, Inge Kersbergen, Eric Robinson
The paper by Leeman and colleagues (2018) makes an important contribution to the broader literature on cognitive bias modification (CBM) for alcohol use disorders. In a balanced discussion, the authors speculate on possible explanations for their null findings, including failure of CBM to change cognitive biases, participant characteristics, and the suitability and sensitivity of the alcohol self-administration paradigm that was the primary outcome measure. The former explanations have been the subject of recent discussion, often heated (see Cristea, Kok, & Cuijpers, 2015, 2017, 2018; Grafton et al...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29652569/efficacy-of-various-pretreatments-on-the-bond-strength-of-denture-teeth-to-denture-base-resins
#17
Fatih Sari, Ozlem Ustun, Omer Kirmali
OBJECTIVE: This in vitro study evaluated the shear bond strength (SBS) of heat-cured denture base resin (PMMA) to acrylic resin teeth treated with different pretreatments, especially laser irradiation of different powers (1-4 W). MATERIALS AND METHODS: The acrylic resin teeth were separated into seven groups (n = 10) for the following different pretreatments: control group (no surface treatment) (G1), grinding with a tungsten carbide bur (G2), sandblasting (G3), and erbium, chromium: yttrium, scandium, gallium, garnet (Er,Cr:YSGG) laser irradiation at 1 W, 2 W, 3 W, 4 W output powers in (G4-7), respectively...
April 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29651925/heptamer-peptide-disassembles-native-amyloid-in-human-plasma-via-heat-shock-protein-70
#18
Timothy James Cunningham, Jeffrey I Greenstein, Lihua Yao, Itzhak Fischer, Theresa Conners
Proteostasis, which includes the repair and disposal of misfolded proteins, depends in part on the activity of heat shock proteins, a well-known class of chaperone molecules. When this process fails abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases but also amass during aging, often in the absence of an identified clinical disorder. We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma...
April 13, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29651510/-vomiting-and-collapse-of-a-28-year-old-male-long-distance-runner-in-middle-european-summer
#19
J Herold, A Mitrasch, E Lorenz, U Lodes, I Tanev, R Braun-Dullaeus, F Meyer
BACKGROUND: Hyperthermia often ends fatally and must therefore be promptly recognized and adequately treated. CASE: A 28-year-old man participated in a long-distance race (3 km) on a hot summer day (28 °C). The runner collapsed, had to vomit but continued the run and reached the finish. Neurologically, the patient presented with intermittent cerebral seizures. External cooling batteries were immediately applied and cold infusions were started. The patient was admitted to the intensive care unit of the university hospital (body temperature 40...
April 12, 2018: Der Internist
https://www.readbyqxmd.com/read/29649670/the-influence-of-the-twin-peg-design-on-femoral-interface-temperature-and-maximum-load-to-failure-in-cemented-oxford-unicompartmental-knee-arthroplasty
#20
Tobias Reiner, Martin Schwarze, Benjamin Panzram, Matthias C Klotz, Rudi G Bitsch, Sebastian Jaeger
BACKGROUND: The twin peg femoral component was introduced for the cemented Oxford unicondylar knee to increase implant stability. The aim of this experimental study was to investigate the influence of the twin peg design on femoral interface temperature and maximum load to failure in comparison to the single peg design. METHODS: In this experimental study medial Oxford unicompartmental knee arthroplasty was performed in 12 pairs of fresh-frozen human knees. A cemented femoral single peg component was implanted on the one side (group A) and a cemented twin peg component on the other side (group B)...
April 5, 2018: Clinical Biomechanics
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