Read by QxMD icon Read

heat failure

XiaoLi Bing, Joseph Gerlach, Gregory Loeb, Nicolas Buchon
Drosophila suzukii Matsumura is an invasive species of vinegar fly that has become a prominent pest of berries and other soft-skinned fruits. Unlike most other Drosophila species, female D. suzukii flies lay their eggs in ripening and ripe fruits and larvae develop within the fruit. To understand how D. suzukii larvae utilize ripe and ripening fruits, which usually have low levels of protein, we investigated the microbiota of field-captured and laboratory-reared D. suzukii flies and further examined the combined influence of diet and microbes on host fitness...
March 20, 2018: MBio
Raffaele Altara, Fouad A Zouein, Rita Dias Brandão, Saeed N Bajestani, Alessandro Cataliotti, George W Booz
Standard therapies for heart failure with preserved ejection fraction (HFpEF) have been unsuccessful, demonstrating that the contribution of the underlying diastolic dysfunction pathophysiology differs from that of systolic dysfunction in heart failure and currently is far from being understood. Complicating the investigation of HFpEF is the contribution of several comorbidities. Here, we selected three established rat models of diastolic dysfunction defined by three major risk factors associated with HFpEF and researched their commonalities and differences...
2018: Frontiers in Cardiovascular Medicine
Zimei Dong, Gengbo Chu, Yingxu Sima, Guangwen Chen
Heat shock protein 90 family members (HSP90s), as molecular chaperones, have conserved roles in the physiological processes of eukaryotes regulating cytoprotection, increasing host resistance and so on. However, whether HSP90s affect regeneration in animals is unclear. Planarians are emerging models for studying regeneration in vivo. Here, the roles of three hsp90 genes from planarian Dugesia japonica are investigated by WISH and RNAi. The results show that: (1) Djhsp90s expressions are induced by heat and cold shock, tissue damage and ionic liquid; (2) Djhsp90s mRNA are mainly distributed each side of the body in intact worms as well as blastemas in regenerative worms; (3) the worms show head regression, lysis, the body curling and the regeneration arrest or even failure after Djhsp90s RNAi; (4) Djhsp90s are involved in autophagy and locomotion of the body...
March 16, 2018: Biochemical and Biophysical Research Communications
Sutapa Mukhopadhyay, Annie Hirsch, Suze Etienne, Natalia Melnikova, Jennifer Wu, Kanta Sircar, Maureen Orr
BACKGROUND: Carbon monoxide (CO) is an insidious gas responsible for approximately 21,000 emergency department visits, 2300 hospitalizations, and 500 deaths in the United States annually. We analyzed 10 combined years of data from two Agency for Toxic Substances and Disease Registry acute hazardous substance release surveillance programs to evaluate CO incident-related injuries. METHODS: Seventeen states participated in these programs during 2005-2014. RESULTS: In those 10years, the states identified 1795 CO incidents...
February 13, 2018: American Journal of Emergency Medicine
Amanda M O Dal Piva, Ronaldo L A Carvalho, Aline L Lima, Marco A Bottino, Renata M Melo, Luiz Felipe Valandro
This study evaluated the influence of silica coating, primer type and its heat treatment on bond strength durability between resin cement and an yttrium-stabilized polycrystalline tetragonal zirconia (Y-TZP). Eighty (80) Y-TZP blocks were allocated into 16 groups considering four factors: silica coating (without and with); type of primer (RelyX Ceramic Primer, a silane-based primer; Single Bond Universal, a universal MDP-based primer); heat treatment of the primer (without and with); aging (without and with)...
March 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Martin S Bojer, Søren Lindemose, Martin Vestergaard, Hanne Ingmer
Incomplete killing of bacterial pathogens by antibiotics is an underlying cause of treatment failure and accompanying complications. Among those avoiding chemotherapy are persisters being individual cells in a population that for extended periods of time survive high antibiotic concentrations proposedly by being in a quiescent state refractory to antibiotic killing. While investigating the human pathogen Staphylococcus aureus and the influence of growth phase on persister formation, we noted that spent supernatants of stationary phase cultures of S...
2018: Frontiers in Microbiology
Behnaz Ebadian, Ramin Mosharraf, Mahsa Abbasi
Background: Residual thermal stresses in dental porcelains can cause clinical failure. Porcelain cooling protocols may affect the amount of residual stresses within porcelain and also porcelain-zirconia bond strength. The objective of this study was to assess the effect of cooling protocols on the fracture load of porcelain veneered zirconia restorations. Materials and Methods: Forty zirconia bars (31 mm × 6.5 mm × 1.35 mm ± 0.1 mm) were fabricated by computer-aided design and computer-aided manufacturing technology...
January 2018: Dental Research Journal
Fabian A Nutz, Alexandra Philipp, Bernd A F Kopera, Martin Dulle, Markus Retsch
Heat transport plays a critical role in modern batteries, electrodes, and capacitors. This is caused by the ongoing miniaturization of such nanotechnological devices, which increases the local power density and hence temperature. Even worse, the introduction of heterostructures and interfaces is often accompanied by a reduction in thermal conductivity, which can ultimately lead to the failure of the entire device. Surprisingly, a fundamental understanding of the governing heat transport processes even in simple systems, such as binary particle mixtures is still missing...
February 27, 2018: Advanced Materials
Wayne Nishio Ayre, Genevieve Melling, Camille Cuveillier, Madhan Natarajan, Jessica L Roberts, Lucy L Marsh, Christopher D Lynch, Jean-Yves Maillard, Stephen P Denyer, Alastair J Sloan
This study investigated the host response to a polymicrobial pulpal infection consisting of Streptococcus anginosus and Enterococcus faecalis , bacteria commonly implicated in dental abscesses and endodontic failure, using a validated ex vivo rat tooth model. Tooth slices were inoculated with planktonic cultures of S. anginosus or E. faecalis alone or in co-culture at ratios of 50:50 and 90:10 S. anginosus to E. faecalis Attachment was semi-quantified by measuring area covered by fluorescently labelled bacteria...
February 26, 2018: Infection and Immunity
Fangzheng Chen, Heng Wang, Junjie Yan, Jiadan Lai, Shujing Cai, Linbo Yuan, Situo Zheng
Heat shock protein 70 (HSP70) is a molecular chaperone which has a low content in cytoplasm under normal physiological conditions. A higher intracytoplasmic HSP70 level can be observed in pulmonary arterial smooth muscle cell (PASMC) in pulmonary arterial hypertension (PAH), and this up-regulation can promote pho-IκBα expression, which is an NF-κB signaling pathway inhibitor. NF-κB signaling pathway up-regulation can promote PASMC proliferation and pulmonary vascular remodeling in PAH, resulting in elevation of pulmonary pressure and the subsequent right heart failure caused by right ventricular hypertrophy...
February 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Duncan Mitchell, Edward P Snelling, Robyn S Hetem, Shane K Maloney, W Maartin Strauss, Andrea Fuller
1.The accuracy of predictive models (also known as mechanistic or causal models) of animal responses to climate change depends on properly incorporating the principles of heat transfer and thermoregulation into those models. Regrettably, proper incorporation of these principles is not always evident. 2.We have revisited the relevant principles of thermal physiology and analyzed how they have been applied in predictive models of large mammals, which are particularly vulnerable, to climate change. We considered dry heat exchange, evaporative heat transfer, the thermoneutral zone and homeothermy, and we examined the roles of size and shape in the thermal physiology of large mammals...
February 26, 2018: Journal of Animal Ecology
Sven Rinke, Anne-Kathrin Pabel, Xenia Schulz, Matthias Rödiger, Gerhard Schmalz, Dirk Ziebolz
OBJECTIVES: Retrospective evaluation of extended anterior glass-ceramic veneers 7 years after placement in a private practice. MATERIALS AND METHODS: A total of 31 patients (20 females/11 males) underwent restoration with adhesively luted extended veneers that were fabricated using heat-pressed glass-ceramic (Cergo, Dentsply Sirona). A single dentist restored 101 teeth (maxilla, n = 65; mandible, n = 36). Adhesive cementation was performed using an etch-and-rinse adhesive (OptibondFL, Kerr Corporation), and two different dual-curing composite cements (Variolink, Ivoclar Vivadent/Calibra, Dentsply Sirona)...
February 24, 2018: Journal of Esthetic and Restorative Dentistry
Yuan-Chieh Lo, Yuh-Chung Hu, Pei-Zen Chang
Thermal characteristic analysis is essential for machine tool spindles because sudden failures may occur due to unexpected thermal issue. This article presents a lumped-parameter Thermal Network Model (TNM) and its parameter estimation scheme, including hardware and software, in order to characterize both the steady-state and transient thermal behavior of machine tool spindles. For the hardware, the authors develop a Bluetooth Temperature Sensor Module (BTSM) which accompanying with three types of temperature-sensing probes (magnetic, screw, and probe)...
February 23, 2018: Sensors
M Nersesjan, D Hägi-Pedersen, J H Andersen, O Mathiesen, J B Dahl, L Broeng, K H Thybo
BACKGROUND: The lateral femoral cutaneous nerve (LFCN) block may be used for post-operative pain management in patients undergoing total hip arthroplasty. The aim of this trial was to investigate the sensory coverage of the posterior and the lateral incision lines and the involvement of the femoral nerve after an LFCN block. METHODS: The study was a randomised, blinded trial in 20 healthy volunteers. All subjects received a bilateral LFCN block randomised to 8 ml ropivacaine on the right side and 8 ml isotonic saline on the left side, or vice versa...
February 21, 2018: Acta Anaesthesiologica Scandinavica
Gaetano Santulli, Daniel Lewis, Amedee des Georges, Andrew R Marks, Joachim Frank
Ryanodine receptors (RyRs) are ubiquitous intracellular calcium (Ca2+ ) release channels required for the function of many organs including heart and skeletal muscle, synaptic transmission in the brain, pancreatic beta cell function, and vascular tone. In disease, defective function of RyRs due either to stress (hyperadrenergic and/or oxidative overload) or genetic mutations can render the channels leaky to Ca2+ and promote defective disease-causing signals as observed in heat failure, muscular dystrophy, diabetes mellitus, and neurodegerative disease...
2018: Sub-cellular Biochemistry
Eiji Yamato
OBJECTIVE: Histone deacytylase inhibitors (HDACis) inhibit the deacetylation of the lysine residue of proteins, including histones, and regulate the transcription of a variety of genes. Recently, HDACis have been used clinically as anti-cancer drugs and possible anti-diabetic drugs. Even though HDACis have been proven to protect the cytokine-induced damage of pancreatic beta cells, evidence also shows that high doses of HDACis are cytotoxic. In the present study, we, therefore, investigated the eff ect of HDACis on insulin secretion in a pancreatic beta cell line...
January 1, 2018: Endocrine Regulations
Jamie Vatish, Nusrat Iqbal, Viswa Retnasingam Rajalingam, Alok Tiwari
OBJECTIVES: The purpose of this study was to evaluate whether anticoagulation (warfarin or direct oral inhibitors) affected the success of endovenous treatment. METHODS: Patients taking anticoagulation (warfarin or direct oral inhibitors) undergoing endovenous treatment in the form of endovenous laser ablation (EVLA) were matched against controls for sex, age, leg, and vein. Data were collected prospectively between January 2012 and March 2017. The primary endpoint was failure of treatment at 6-week postoperative duplex scan...
January 1, 2018: Vascular and Endovascular Surgery
Hasan Goktas
Here, we demonstrate the advantages of the laser Doppler vibrometer (LDV) over conventional techniques (the network analyzer), as well as the techniques to create an application-based microelectromechanical systems (MEMS) filter and how to use it efficiently (i.e., tuning the tuning-capability and avoiding both failure and stiction). LDV enables crucial measurements that are impossible with the network analyzer, such as higher mode detection (highly sensitive biosensor application) and resonance measurement for very small devices (fast prototyping)...
February 4, 2018: Journal of Visualized Experiments: JoVE
Xiao-Shan Zhang, Ling-Wei Yang, Hai-Tao Liu, Mei Zu
Carbon nanotube (CNT) fibers are promising reinforcements in ceramic matrix composites where the service environments involve extremely high temperatures that are generally beyond 1000 °C. This work focuses on the thermal stability of a direct spun CNT fiber in vacuum and in a wide temperature (25-2000 °C). The microstructure, mechanical and electrical properties of the fibers as a function of the heat-treatment temperature were investigated. The results show that high temperature exposure could increase the defect density and loosen the packing state of the fiber, but enhance the graphitization degree of the CNTs...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Reena Kamal, Triveni Dutt, Manjunath Patel, Amitava Dey, Panch Kishore Bharti, Poolangulam Chinnakkan Chandran
In tropical countries, at high temperatures, several physiological rearrangements occur in cows as they attempt to facilitate heat dissipation and/or reduce metabolic heat production. Following exposure to heat, cattle appear to acclimatize within 2-7 weeks. The failure of homeostasis at high temperatures may lead to reduced productivity or even death. The situation is even worse when humidity adds to high temperature. Livestock with elevated body temperature exhibit lower DMI and growth with less efficiency, reducing profitability for dairy farms in hot and humid climates...
February 13, 2018: Tropical Animal Health and Production
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"