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https://www.readbyqxmd.com/read/29787733/the-major-outer-membrane-protein-of-legionella-pneumophila-lpg1974-shows-pore-forming-characteristics-similar-to-the-human-mitochondrial-outer-membrane-pore-hvdac1
#1
Farhan Younas, Nafiseh Soltanmohammadi, Oliver Knapp, Roland Benz
Legionella pneumophila is an aerobic and nonspore-forming pathogenic Gram-negative bacterium of the genus Legionella. It is the causative agent of Legionnaires' disease, also known as Legionellosis. The hosts of this organism are diverse, ranging from simple water borne protozoans such as amoebae to more complex hosts such as macrophages in humans. Genome analyses have shown the presence of genes coding for eukaryotic like proteins in several Legionella species. The presence of these proteins may assist L. pneumophila in its adaptation to the eukaryotic host...
May 19, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29784251/corrigendum-to-sennoside-a-protects-mitochondrial-structure-and-function-to-improve-high-fat-diet-induced-hepatic-steatosis-by-targeting-vdac1-biochem-biophys-res-commun-500-2018-484-489
#2
Jiamei Le, Weiping Jia, Yongning Sun
No abstract text is available yet for this article.
May 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29747160/targeting-liver-cancer-and-associated-pathologies-in-mice-with-a-mitochondrial-vdac1-based-peptide
#3
Srinivas Pittala, Yakov Krelin, Varda Shoshan-Barmatz
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Despite progress in identifying risk factors, the incidence of HCC is increasing. Moreover, therapeutic options are limited and survival is poor. Therefore, alternative and innovative therapeutic strategies are urgently required. R-Tf-D-LP4, a cell-penetrating peptide derived from the mitochondrial multifunctional protein the voltage-dependent anion channel (VDAC1), is identified here as a highly effective liver cancer treatment. Recently, we demonstrated that R-Tf-D-LP4 induced apoptosis and inhibited tumor growth in mouse models...
May 7, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29715546/tdp-43-interacts-with-mitochondrial-proteins-critical-for-mitophagy-and-mitochondrial-dynamics
#4
Stephani A Davis, Sheed Itaman, Christopher M Khalid-Janney, Justin A Sherard, James A Dowell, Nigel J Cairns, Michael A Gitcho
Transactive response DNA-binding protein of 43 kDa (TDP-43) functions as a heterogeneous nuclear ribonucleoprotein and is the major pathological protein in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis/motor neuron disease (ALS/MND). TDP-43 pathology may also be present as a comorbidity in approximately 20-50% of sporadic Alzheimer's disease cases. In a mouse model of MND, full-length TDP-43 increases association with the mitochondria and blocking the TDP-43/mitochondria interaction ameliorates motor dysfunction...
April 30, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29698587/selective-induction-of-cancer-cell-death-by-vdac1-based-peptides-and-their-potential-use-in-cancer-therapy
#5
Anna Shteinfer-Kuzmine, Zohar Amsalem, Tasleem Arif, Alexandra Zooravlov, Varda Shoshan-Barmatz
Mitochondrial VDAC1 mediates cross-talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+ and metabolites, and serves as a key player in apoptosis. As such, VDAC1 is involved in two important hallmarks of cancer development, namely energy and metabolic reprograming and apoptotic cell death evasion. We previously developed cell-penetrating VDAC1-derived peptides that interact with hexokinase (HK), Bcl-2 and Bcl-xL to prevent the anti-apoptotic activities of these proteins and induce cancer cell death, with a focus on leukemia and glioblastoma...
April 26, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29682501/vdac1-as-pharmacological-target-in-cancer-and-neurodegeneration-focus-on-its-role-in-apoptosis
#6
REVIEW
Andrea Magrì, Simona Reina, Vito De Pinto
Cancer and neurodegeneration are different classes of diseases that share the involvement of mitochondria in their pathogenesis. Whereas the high glycolytic rate (the so-called Warburg metabolism) and the suppression of apoptosis are key elements for the establishment and maintenance of cancer cells, mitochondrial dysfunction and increased cell death mark neurodegeneration. As a main actor in the regulation of cell metabolism and apoptosis, VDAC may represent the common point between these two broad families of pathologies...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29682182/anti-cancerous-effect-of-cis-khellactone-from-angelica-amurensis-through-the-induction-of-three-programmed-cell-deaths
#7
Samil Jung, Hyung-In Moon, Beom Suk Lee, Subeen Kim, Nguyen Thi Ngoc Quynh, Jimin Yu, Dan-Diem Thi Le, Zolzaya Sandag, Hyegyeong Lee, Hyojeong Lee, Nguyen Hai Anh, Young Yang, Jong-Seok Lim, Keun-Il Kim, Myeong-Sok Lee
Angelica amurensis has traditionally been used to treat various medical problems. In this report, we introduce cis-khellactone as a new anti-cancer agent, which was isolated from the chloroform soluble fraction of the rhizomes of Angelica amurensis . Its anti-cancerous effect was at first tested in MCF7 and MDA-MB-231 breast cell lines, in which MCF7 is well known to be resistant to many anti-cancer drugs; MCF10A normal breast cell line was used as a control. In vitro experiments showed that cis-khellactone suppressed cell growth and proliferation at a relatively low concentrations (<5 μg/ml) and decreased cell viability at high concentrations (>10 μg/ml) in both cancer cell lines in a time- and concentration-dependent manner...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29676259/mfn2-ubiquitination-by-pink1-parkin-gates-the-p97-dependent-release-of-er-from-mitochondria-to-drive-mitophagy
#8
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions are destroyed during mitophagy, and reducing mitochondria-ER contacts increases the rate of mitochondrial degradation. Mechanistically, parkin/PINK1 catalyze a rapid burst of Mfn2 phosphoubiquitination to trigger p97-dependent disassembly of Mfn2 complexes from the outer mitochondrial membrane, dissociating mitochondria from the ER...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29675103/mir-490-3p-functions-as-a-tumor-suppressor-by-inhibiting-oncogene-vdac1-expression-in-colorectal-cancer
#9
Xiangxiang Liu, Bangshun He, Tao Xu, Yuqin Pan, Xiuxiu Hu, Xiaoxiang Chen, Shukui Wang
Colorectal cancer (CRC) is one of the most common cancers worldwide, usually with poor prognosis because many CRC patients are diagnosed at an advanced stage. Therefore, novel potential diagnostic and prognostic biomarkers are urgently needed. MicroRNAs have been reported to regulate a variety of biological processes, such as cell proliferation, differentiation and apoptosis. Accumulating studies have demonstrated that miR-490-3p could regulate the development and progression of multiple cancers, but its clinical significance and molecular mechanism in CRC are still elusive...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29673597/sennoside-a-protects-mitochondrial-structure-and-function-to-improve-high-fat-diet-induced-hepatic-steatosis-by-targeting-vdac1
#10
Jiamei Le, Weiping Jia, Yongning Sun
Mitochondrial dysfunction is mainly associated with high-fat-diet (HFD)-induced hepatic steatosis. Sennoside A (SA), a commonly used clinical stimulant laxative, is reported to improve energy metabolism and insulin resistance. However, the effect and mechanism of SA on HFD-induced hepatic steatosis remain largely unknown. The aim of this study was to determine the effect and mechanism of SA on HFD-induced hepatic steatosis in mice. We examined the liver and body weight of mice to evaluate the physical changes in the liver...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29596470/dysfunction-in-the-mitochondrial-fe-s-assembly-machinery-leads-to-formation-of-the-chemoresistant-truncated-vdac1-isoform-without-hif-1%C3%AE-activation
#11
Ioana Ferecatu, Frédéric Canal, Lucilla Fabbri, Nathalie M Mazure, Cécile Bouton, Marie-Pierre Golinelli-Cohen
Biogenesis of iron-sulfur clusters (ISC) is essential to almost all forms of life and involves complex protein machineries. This process is initiated within the mitochondrial matrix by the ISC assembly machinery. Cohort and case report studies have linked mutations in ISC assembly machinery to severe mitochondrial diseases. The voltage-dependent anion channel (VDAC) located within the mitochondrial outer membrane regulates both cell metabolism and apoptosis. Recently, the C-terminal truncation of the VDAC1 isoform, termed VDAC1-ΔC, has been observed in chemoresistant late-stage tumor cells grown under hypoxic conditions with activation of the hypoxia-response nuclear factor HIF-1α...
2018: PloS One
https://www.readbyqxmd.com/read/29593233/mechanism-of-translation-control-of-the-alternative-drosophila-melanogaster-voltage-dependent-anion-selective-channel-1-mrnas
#12
L Leggio, F Guarino, A Magrì, R Accardi-Gheit, S Reina, V Specchia, F Damiano, M F Tomasello, M Tommasino, A Messina
The eukaryotic porin, also called the Voltage Dependent Anion-selective Channel (VDAC), is the main pore-forming protein of the outer mitochondrial membrane. In Drosophila melanogaster, a cluster of genes evolutionarily linked to VDAC is present on chromosome 2L. The main VDAC isoform, called VDAC1 (Porin1), is expressed from the first gene of the cluster. The porin1 gene produces two splice variants, 1A-VDAC and 1B-VDAC, with the same coding sequence but different 5' untranslated regions (UTRs). Here, we studied the influence of the two 5' UTRs, 1A-5' UTR and 1B-5' UTR, on transcription and translation of VDAC1 mRNAs...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29560113/hypoxic-induced-truncation-of-voltage-dependent-anion-channel-1-is-mediated-by-both-asparagine-endopeptidase-and-calpain-1-activities
#13
Hadas Pahima, Simona Reina, Noa Tadmor, Daniella Dadon-Klein, Anna Shteinfer-Kuzmine, Nathalie M Mazure, Vito De Pinto, Varda Shoshan-Barmatz
The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane (OMM) protein, serves as a mitochondrial gatekeeper, mediating the transport of nucleotides, Ca2+ and other metabolites across the OMM. VDAC1 also plays a central role in mitochondria-mediated apoptosis by facilitating the release of apoptotic proteins and by association with both pro- and anti-apoptotic proteins. Tumor cells, which are constantly exposed to hypoxic conditions, affect the cell via the transcription factor hypoxia-inducible factor (HIF) that induces transcriptional activity...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29551631/vdac1-mitochondrial-dysfunction-and-alzheimer-s-disease
#14
REVIEW
Varda Shoshan-Barmatz, Edna Nahon-Crystal, Anna Shteinfer-Kuzmine, Rajeev Gupta
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear. Mitochondrial dysfunction has been identified as an early event in AD pathogenesis and is reflected by reduced metabolism, disruption of Ca2+ homeostasis, and increased levels of reactive oxygen species, lipid peroxidation, and apoptosis. The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to AD pathogenesis...
May 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29404888/hiv-1-nef-cawleaq-motif-a-regulator-of-monocytes-invasion-through-eno1-modulation
#15
Reshu Saxena, Umesh Kumar Vekariya, Pradeep Kumar, Amit Kumar Tripathi, Jimut Kanti Ghosh, Raj Kamal Tripathi
HIV-1 transmission and spread involves significant host-virus interaction. Possible targets for obstacle of HIV-1 lie at the site of mucosal barriers. Thus a better understanding of how HIV-1 infects target cells at such sites and leads their invasion is required, with prime focus on the host determinants regulating HIV-1 spread. For the viral infectivity and pathogenicity, HIV-1 Nef facilitates immune evasion through protein-protein interactions within host cell. HIV-1 Nef is significant for viral infectivity and pathogenicity...
February 5, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29343040/-effect-of-picroside-%C3%A2-on-the-expression-of-mitochondrial-vdac1-after-cerebral-ischemia-reperfusion-in-rats
#16
S Li, T T Wang, L Zhai, W W Deng, Y L Guo, J X Jiang
Objective: To explore the effect of picroside Ⅱ on the expression of mitochondrial voltage-dependent anion channel 1 (VDAC1) in rats after cerebral ischemiareperfusion. Methods: A total of 70 Wistar rats models with middle cerebral artery occlusionreperfusion (MCAO/R) were randomly divided into the sham group, model group, picroside (Picr) group, ruthenium red (RuR) group, RuR+ Picr group, Spermine (Sper) group, Sper+ Picr group (n=10 per group). Modified neurological severity scale (mNSS) was used to evaluated the neurobehavioral function, the expression of reactive oxygen species (ROS) in brain tissues were measured by enzyme-linked immunosorbent assay (ELISA), the morphology of brain tissues was observed by hematoxylin-eosin (HE) staining, the apoptotic cells were counted by terminal deoxynucleotidyl transferase dUTP nick end labeling assay (TUNEL), and the expressions of VDAC1 and endonuclease G (EndoG) were determined by immunohistochemical assay and Western blot...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29321137/novel-function-of-ceramide-for-regulation-of-mitochondrial-atp-release-in-astrocytes
#17
Ji-Na Kong, Zhihui Zhu, Yutaka Itokazu, Guanghu Wang, Michael B Dinkins, Liansheng Zhong, Hsuan-Pei Lin, Ahmed Elsherbini, Silvia Leanhart, Xue Jiang, Haiyan Qin, Wenbo Zhi, Stefka D Spassieva, Erhard Bieberich
We reported that amyloid β peptide (Aβ42 ) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that Aβ42 induced mitochondrial fragmentation in wild-type astrocytes, but not in nSMase2-deficient cells or astrocytes treated with fumonisin B1 (FB1), an inhibitor of ceramide synthases. Unexpectedly, ceramide depletion was concurrent with rapid movements of mitochondria, indicating an unknown function of ceramide for mitochondria...
March 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29279396/protonation-state-of-glutamate-73-regulates-the-formation-of-a-specific-dimeric-association-of-mvdac1
#18
Lucie A Bergdoll, Michael T Lerch, John W Patrick, Kendrick Belardo, Christian Altenbach, Paola Bisignano, Arthur Laganowsky, Michael Grabe, Wayne L Hubbell, Jeff Abramson
The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane and constitutes the primary pathway for the exchange of ions and metabolites between the cytosol and the mitochondria. There is accumulating evidence supporting VDAC's role in mitochondrial metabolic regulation and apoptosis, where VDAC oligomerization has been implicated with these processes. Herein, we report a specific pH-dependent dimerization of murine VDAC1 (mVDAC1) identified by double electron-electron resonance and native mass spectrometry...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229420/ros-mediated-oligomerization-of-vdac2-is-associated-with-quinocetone-induced-apoptotic-cell-death
#19
Xiayun Yang, Shusheng Tang, Daowen Li, Bin Li, Xilong Xiao
Quinocetone (QCT) has been approved and widely used as an animal feed additive in China since 2003. However, investigations indicate that QCT shows potential toxicity both in vitro and in vivo. Although voltage dependent anion channel 1 (VDAC1) involved in regulating QCT-induced apoptotic cell death has been established, the role of voltage dependent anion channel 2 (VDAC2) in QCT-induced toxicity remains unclear. In this study, we showed that QCT-induced cell death was coupled to VDAC2 oligomerization. Moreover, VDAC inhibitor 4, 4'-diisothiocyano stilbene-2, 2'-disulfonic acid (DIDS) alleviated QCT-induced cell death and VDAC2 oligomerization...
March 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29196874/upregulation-of-spinal-voltage-dependent-anion-channel-1-contributes-to-bone-cancer-pain-hypersensitivity-in-rats
#20
Xiangpeng Kong, Jinrong Wei, Diyu Wang, Xiaoju Zhu, Youlang Zhou, Shusheng Wang, Guang-Yin Xu, Guo-Qin Jiang
Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4 (TLR4)...
December 2017: Neuroscience Bulletin
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