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https://www.readbyqxmd.com/read/29016235/telemedicine-support-groups-for-home-parenteral-nutrition-users
#1
Eve-Lynn Nelson, Donna Macan Yadrich, Noreen Thompson, Shawna Wright, Kathaleen Stone, Natasia Adams, Marilyn Werkowitch, Carol E Smith
Patients receiving home parenteral nutrition (HPN), a life-sustaining intravenous (IV) infusion that provides nourishment and hydration to patients with short gut or inflammatory bowel diseases, are often isolated and not in visual contact with peers or health providers. One completed clinical trial (Clinical Trials.gov NCT0190028) and 1 ongoing clinical trial (Clinical Trials.gov NCT02987569) are evaluating a mobile videoconferencing-delivered support group intervention for patients on HPN and their caregivers...
October 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29016233/metabolic-complications-of-home-parenteral-nutrition
#2
Jamie Davila, Denise Konrad
Home parenteral nutrition (HPN) has benefited countless patients since its initiation almost 5 decades ago. Over time, HPN has been found to be associated with various complications, including metabolic disorders. Metabolic complications can be grouped into short-term (eg, fluid imbalance, electrolyte disturbances, glucose abnormalities) and long-term (eg, hepatobiliary disorders, metabolic bone disease, iron deficiency anemia, manganese toxicity) categories. There are a number of treatment options for each complication...
October 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29016220/considerations-for-fueling-an-endurance-athlete-with-home-parenteral-nutrition
#3
Emma M Tillman, Marianne Opilla
The goal of clinicians managing nutrition support for patients with home parenteral nutrition (HPN) is to adapt nutrition needs to best serve the consumers, so they may have the best quality of life despite specialized nutrition needs. Some HPN consumers may desire to participate in endurance athletics, which will require special considerations. This review is intended to outline key nutrition differences in endurance athletes that a nutrition support team should consider when providing HPN.
October 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28945530/haloplanus-salinarum-sp-nov-an-extremely-halophilic-archaeon-isolated-from-a-solar-saltern
#4
Han-Bit Hwang, Ye-Eun Kim, Hyeon-Woo Koh, Hye Seon Song, Seong Woon Roh, So-Jeong Kim, Seung Won Nam, Soo-Je Park
An extremely halophilic archaeal strain SP28T was isolated from the Gomso solar saltern, Republic of Korea. Cells of the new strain SP28T were pleomorphic and Gram stain negative, and produced red-pigmented colonies. These grew in medium with 2.5-4.5 M NaCl (optimum 3.1 M) and 0.05-0.5 M MgCl2 (optimum 0.1 M), at 25-50 °C (optimum 37 °C) and at a pH of 6.5-8.5 (optimum pH 8.0). Mg2+ was required for growth. A concentration of at least 2 M NaCl was required to prevent cell lysis. Polar lipids included phosphatidylglycerol, phosphatidylglycerol phosphate methyl ester, phosphatidylglycerol sulfate and one glycolipid chromatographically identical to sulfated mannosyl glucosyl diether...
September 25, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28944497/evolutionarily-derived-networks-to-inform-disease-pathways
#5
Britney E Graham, Christian Darabos, Minjun Huang, Louis J Muglia, Jason H Moore, Scott M Williams
Methods to identify genes or pathways associated with complex diseases are often inadequate to elucidate most risk because they make implicit and oversimplified assumptions about underlying models of disease etiology. These can lead to incomplete or inadequate conclusions. To address this, we previously developed human phenotype networks (HPN), linking phenotypes based on shared biology. However, such visualization alone is often uninterpretable, and requires additional filtering. Here, we expand the HPN to include another method, evolutionary triangulation (ET)...
September 25, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28891586/poly-n-acryloyl-l-phenylalanine-methyl-ester-hollow-core-nanocapsules-facilitate-sustained-delivery-of-immunomodulatory-drugs-and-exhibit-adjuvant-properties
#6
Anil Kumar Yamala, Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, Pradip Paik
Polymeric hollow nanocapsules have attracted significant research attention as novel drug carriers and their preparation is of particular concern owing to the feasibility to encapsulate a broad range of drug molecules. This work presents for the first time the synthesis and development of novel poly-N-acryloyl l-phenylalanine methyl ester hollow core nanocapsules (NAPA-HPNs) of avg. size ca. 100-150 nm by the mini-emulsion technique. NAPA-HPNs are biocompatible and capable of encapsulating sodium nitroprusside (SNP) at a rate of ∼1...
September 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28886448/exploring-hepsin-functional-genetic-variation-association-with-disease-specific-protein-expression-in-bipolar-disorder-applications-of-a-proteomic-informed-genomic-approach
#7
Malik Nassan, Yun-Fang Jia, Greg Jenkins, Colin Colby, Scott Feeder, Doo-Sup Choi, Marin Veldic, Susan L McElroy, David J Bond, Richard Weinshilboum, Joanna M Biernacka, Mark A Frye
In a prior discovery study, increased levels of serum Growth Differentiation Factor 15 (GDF15), Hepsin (HPN), and Matrix Metalloproteinase-7 (MMP7) were observed in bipolar depressed patients vs controls. This exploratory post-hoc analysis applied a proteomic-informed genomic research strategy to study the potential functional role of these proteins in bipolar disorder (BP). Utilizing the Genotype-Tissue Expression (GTEx) database to identify cis-acting blood expression quantitative trait loci (cis-eQTLs), five eQTL variants from the HPN gene were analyzed for association with BP cases using genotype data of cases from the discovery study (n = 58) versus healthy controls (n = 777)...
July 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28839904/uk-practice-in-the-prevention-of-central-venous-catheter-associated-thrombosis-in-adults-on-home-parenteral-nutrition
#8
L Macdougall, J Hanley, C Mountford, N P Thompson
BACKGROUND: Maintaining central access is imperative for the delivery of home parenteral nutrition (HPN) in those with intestinal failure. Methods to reduce central venous catheter infection are well recognised; however, the prevention of line thrombosis is less well studied. METHODS: This paper reviews the current evidence and reports a survey of current practice within the UK. Using an electronic survey, respondents were asked to detail their use of anticoagulation in different patient groups and the type of anticoagulation used...
July 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28833145/extrusion-modifies-some-physicochemical-properties-of-milk-protein-concentrate-for-improved-performance-in-high-protein-nutrition-bars
#9
Justin C Banach, Stephanie Clark, Buddhi P Lamsal
BACKGROUND: Extruded and ground milk protein concentrate powders, specifically those with 800 g kg(-1) protein (i.e. MPC80), imparted softness, cohesion and textural stability to high-protein nutrition (HPN) bars. The present study evaluated some physicochemical properties of extruded and conventionally produced (i.e. spray-dried) MPC80 to explain these improvements. Protein chemical changes and aggregations within MPC80-formulated HPN bars during storage were characterized. RESULTS: Extruded MPC80 powders had broader particle size distribution (P < 0...
August 22, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28832600/hpn-07-a-free-radical-spin-trapping-agent-protects-against-functional-cellular-and-electrophysiological-changes-in-the-cochlea-induced-by-acute-acoustic-trauma
#10
Donald Ewert, Ning Hu, Xiaoping Du, Wei Li, Matthew B West, Chul-Hee Choi, Robert Floyd, Richard D Kopke
Oxidative stress is considered a major cause of the structural and functional changes associated with auditory pathologies induced by exposure to acute acoustic trauma AAT). In the present study, we examined the otoprotective effects of 2,4-disulfophenyl-N-tert-butylnitrone (HPN-07), a nitrone-based free radical trap, on the physiological and cellular changes in the auditory system of chinchilla following a six-hour exposure to 4 kHz octave band noise at 105 dB SPL. HPN-07 has been shown to suppress oxidative stress in biological models of a variety of disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28829676/content-validation-of-a-home-parenteral-nutrition-patient-reported-outcome-questionnaire
#11
Tracy-Lee Miller, Geoffrey W Greene, Ingrid Lofgren, Mary L Greaney, Marion F Winkler
BACKGROUND: Patient-reported outcome (PRO) instruments collect information from patients about health conditions and disease management, including quality of life (QOL). Clinicians acknowledge patient concerns about QOL but need guidance to assess the nature and severity of individually experienced problems. The Home Parenteral Nutrition (HPN)-Patient-Reported Outcome Questionnaire (PROQ) was developed for use during medical appointments or homecare visits to address this gap. The purpose of this research was to provide evidence that the HPN-PROQ items and scale possess content validity...
August 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28825835/li-o2-cell-with-lii-3-hydroxypropionitrile-2-as-a-redox-mediator-insight-into-the-working-mechanism-of-i-during-charge-in-anhydrous-systems
#12
Yang Li, Shanmu Dong, Bingbing Chen, Chenglong Lu, Kailiang Liu, Zhonghua Zhang, Huiping Du, Xiaogang Wang, Xiao Chen, Xinhong Zhou, Guanglei Cui
Redox mediators (RMs) have been widely applied to reduce the charge overpotential of nonaqueous lithium-oxygen (Li-O2) batteries. Among the reported RMs, LiI is under hot debate with lots of controversial reports. However, there is a limited understanding of the charge mechanism of I(-) in anhydrous Li-O2 batteries. Here, we study the chemical reactivity between the oxidized state of I(-) and Li2O2. We confirm that the Li2O2 particles could be chemically oxidized by I2 rather than I3(-) species. Furthermore, our work demonstrates that the generated I(-) from Li2O2 oxidation would combine with I2 to give I3(-) species, hindering further oxidation of Li2O2 by I2...
August 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28792647/ultra-short-bowel-is-an-independent-risk-factor-for-liver-fibrosis-in-adults-with-home-parenteral-nutrition
#13
Dominique Cazals-Hatem, Lore Billiauws, Pierre-Emmanuel Rautou, Vanessa Bondjemah, Nicolas Poté, Olivier Corcos, Valérie Paradis, Francisca Joly
BACKGROUND & AIMS: Intestinal failure-associated liver disease is rare in adults and risk factors are unclear. The aim of this study was to determine risk factors of liver fibrosis in adults receiving home parenteral nutrition for intestinal failure and its impact on survival. METHODS: We retrospectively analysed patients with irreversible intestinal failure who underwent a liver biopsy between 2000 and 2013. Significant liver fibrosis was defined as ≥F2 according to NASH-CRN score...
August 9, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28768249/paediatric-home-parenteral-nutrition-in-the-czech-republic-and-its-development-multicentre-retrospective-study-1995-2011
#14
Jitka Stýblová, Jana Kalousová, Miroslava Adamcová, Kateřina Bajerová, Jiří Bronský, Filip Fencl, Eva Karásková, Petra Keslová, Jan Melek, Oldřich Pozler, Václav Sebroň, Astrid Šuláková, Jana Tejnická, Peter Tláskal, Ladislav Tomášek, Barbora Vlková, Peter Szitányi
BACKGROUND: Treatment quality and outcomes of paediatric home parenteral nutrition (HPN) program during its development in the Czech Republic. METHODS: A retrospective study of patients receiving HPN from May 1995 till June 2011. RESULTS: Sixty-six patients were treated in 8 centres. In 48 patients, long-term PN began in the first year of life and in 35 of them in the first month. Sixty children had gastrointestinal and 6 had non-gastrointestinal disease...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28763009/metal-binding-properties-of-the-n-terminus-of-the-functional-amyloid-orb2
#15
Thalia H Bajakian, Silvia A Cervantes, Maria A Soria, Maïwenn Beaugrand, Ji Yun Kim, Rachel J Service, Ansgar B Siemer
The cytoplasmic polyadenylation element binding protein (CPEB) homologue Orb2 is a functional amyloid that plays a key regulatory role for long-term memory in Drosophila. Orb2 has a glutamine, histidine-rich (Q/H-rich) domain that resembles the Q/H-rich, metal binding domain of the Hpn-like protein (Hpnl) found in Helicobacter pylori. In the present study, we used chromatography and isothermal titration calorimetry (ITC) to show that the Q/H-rich domain of Orb2 binds Ni(2+) and other transition metals ions with μM affinity...
August 1, 2017: Biomolecules
https://www.readbyqxmd.com/read/28740349/functional-lipidomics-in-patients-on-home-parenteral-nutrition-effect-of-lipid-emulsions
#16
Loris Pironi, Mariacristina Guidetti, Ornella Verrastro, Claudia Iacona, Federica Agostini, Caterina Pazzeschi, Anna Simona Sasdelli, Michele Melchiorre, Carla Ferreri
AIM: To investigate the fatty acid-based functional lipidomics of patients on long-term home parenteral nutrition receiving different intravenous lipid emulsions. METHODS: A cross-sectional comparative study was carried out on 3 groups of adults on home parenteral nutrition (HPN), receiving an HPN admixture containing an olive-soybean oil-based intravenous lipid emulsion (IVLE) (OO-IVLE; n = 15), a soybean- medium-chain triacylglycerol-olive-fish oil-based IVLE (SMOF-IVLE; n = 8) or HPN without IVLE (No-IVLE; n = 8) and 42 healthy controls (HCs)...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28715295/prevalence-of-home-parenteral-and-enteral-nutrition-in-the-united-states
#17
Manpreet S Mundi, Adele Pattinson, Megan T McMahon, Jacob Davidson, Ryan T Hurt
BACKGROUND: Malnutrition is highly prevalent and associated with increased morbidity and mortality. Studies continue to reveal significant clinical benefits with nutrition support, including improved wound healing, reduction in complications and length of stay, and mortality. Due to these benefits, the prevalence of home parenteral and enteral nutrition (HPEN) continues to increase worldwide. In the United States, given our healthcare insurance landscape, it has been very difficult to ascertain the true prevalence of HPEN...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28702099/strategies-for-early-metabolic-disturbances-in-patients-with-an-end-jejunostomy-or-end-ileostomy-experience-from-a-specialized-home-parenteral-nutrition-hpn-center
#18
Michał Ławiński, Dominika Haraszczuk, Aleksandra Gradowska, Justyna Z Kostro, Agnieszka Bzikowska, Jacek Sobocki
INTRODUCTION: An end stoma syndrome is usually the result of an intentional surgical intervention in the course of staged treatment or a complication of surgery. These patients most frequently suffer from water and electrolyte disturbances, malnutrition syndromes caused by malabsorption of trace elements and/or vitamins, and undernutrition. AIM: To present early metabolic disturbances observed in patients with an end jejunostomy or end ileostomy syndrome on the first day of their hospitalization in a specialist Home Parenteral Nutrition (HPN) center...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28701261/five-year-survival-and-causes-of-death-in-patients-on-home-parenteral-nutrition-for-severe-chronic-and-benign-intestinal-failure
#19
Francisca Joly, Janet Baxter, Michael Staun, Darlene G Kelly, Yi Lisa Hwa, Olivier Corcos, Antonella De Francesco, Federica Agostini, Stanislaw Klek, Lidia Santarpia, Franco Contaldo, Cora Jonker, Geert Wanten, Luisa Chicharro, Rosa Burgos, Andre Van Gossum, Cristina Cuerda, Nuria Virgili, Loris Pironi
BACKGROUND & AIM: Home parenteral nutrition (HPN) is the primary treatment for chronic intestinal failure (IF). Intestinal transplantation (ITx) is indicated when there is an increased risk of death due to HPN complications or to the underlying disease. Age, pathophysiologic conditions and underlying disease are known predictors of HPN dependency and overall survival. Although the cause of death on HPN is mostly related to underlying disease in these patients, the relationship between mortality and duration of HPN use remains unclear...
June 19, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28674586/-epidemiological-clinical-aspects-and-management-of-urethral-stenosis-in-adult-patients-in-a-district-hospital-in-ngaound%C3%A3-r%C3%A3-cameroon
#20
Ngaroua, Ngah Joseph Eloundou, Yaouba Djibrilla, Ousmane Asmaou, Amvene Jérémie Mbo
INTRODUCTION: The aim was to determine the epidemiological, clinical aspects and the management of these patients in Ngaoundere Protestant Hospital (HPN). METHODS: We conducted a retrospective review of complete medical records of patients hospitalized for urethral stenosis in the Department of Urology at the Protestant Hospital of Ngaoundéré over a one-year period (January 2013 to January 2014). RESULTS: Out of 69 registered medical records, a total of 57 patients files (all male) were identified for review...
2017: Pan African Medical Journal
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