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https://www.readbyqxmd.com/read/28532142/a-case-of-advanced-unicentric-retroperitoneal-castleman-s-disease-associated-with-psoriasis
#1
Mohammad Ali Mohagheghi, Ramesh Omranipur, Fereshteh Ensani, Alireza Ghannadan, Shahriar Shahriaran, Farhad Samiee, Zahra Sedighi
We present here a 32-year-old male with advanced lately diagnosed, right sided retroperitoneal mass, which had been already treated due to progressive muco-cutaneous lesions clinically consistent with psoriasis, during recent four years. The advanced retroperitoneal mass resected surgically and reported as hyaline-vascular castleman disease with a dense focus of coarse calcification, on histopathology. Association of psoriasis and castlman disease is discussed in this case report.
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28532009/exploring-recent-developments-to-improve-antioxidant-anti-inflammatory-and-antimicrobial-efficacy-of-curcumin-a-review-of-new-trends-and-future-perspectives
#2
REVIEW
Zahid Hussain, Hnin Ei Thu, Muhammad Wahab Amjad, Fahad Hussain, Tarek A Ahmed, Shahzeb Khan
Curcumin derivatives have been well-documented due to their natural antioxidant, antimicrobial and anti-inflammatory activities. Curcuminoids have also gained widespread recognition due to their wide range of other activities which include anti-infective, anti-mutagenic, anticancer, anti-coagulant, antiarthrititc, and wound healing potential. Despite of having a wide range of activities, the inherent physicochemical characteristics (poor water solubility, low bioavailability, chemical instability, photodegradation, rapid metabolism and short half-life) of curcumin derivatives limit their pharmaceutical significance...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532007/decellularized-tendon-as-a-prospective-scaffold-for-tendon-repair
#3
REVIEW
Shengyu Wang, Yiyun Wang, Liyang Song, Jiaxin Chen, Yujie Ma, Yunbin Chen, Shunwu Fan, Miaoshang Su, Xianfeng Lin
Tendon injuries impose significant clinical burdens on healthcare systems worldwide. At present, no therapeutic methods can cure tendon injuries in an ideal manner. With the development and improvement of decellularization technology, tendon extracellular matrix (ECM) can develop into novel scaffolds with potential for repairing injured tendons. Proper agents and decellularization protocols were developed to obtain tendon ECMs, and the method used to recellularize the tendon ECM was explored to create bio-functional neo-tendons for transplants...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531344/citation-classics-in-neuro-oncology-assessment-of-historical-trends-and-scientific-progress
#4
Laureen D Hachem, Alireza Mansouri, Kyle Juraschka, Shervin Taslimi, Farhad Pirouzmand, Gelareh Zadeh
Background.: Citation classics represent the highest cited works in a field and are often regarded as the most influential literature. Analyzing thematic trends in citation classics across eras enables recognition of important historical advances within a field. We present the first analysis of the citation classics in neuro-oncology. Methods.: The Web of Science database was searched using terms relevant to "neuro-oncology." Articles with >400 citations were identified and the top 100 cited articles were evaluated...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28531331/diagnostic-challenges-in-meningioma
#5
Martha Nowosielski, Nobert Galldiks, Sarah Iglseder, Philipp Kickingereder, Andreas von Deimling, Martin Bendszus, Wolfgang Wick, Felix Sahm
Advances in molecular profiling and the application of advanced imaging techniques are currently refreshing diagnostic considerations in meningioma patients. Not only technical refinements but also sophisticated histopathological and molecular studies have the potential to overcome some of the challenges during meningioma management. Exact tumor delineation, assessment of tumor growth and pathophysiological parameters were recently addressed by "advanced" magnetic resonance imaging and positron emission tomography...
May 20, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28531300/anosmia-a-clinical-review
#6
Sanne Boesveldt, Elbrich M Postma, Duncan Boak, Antje Welge-Luessen, Veronika Schöpf, Joel D Mainland, Jeffrey Martens, John Ngai, Valerie B Duffy
Anosmia and hyposmia, the inability or decreased ability to smell, is estimated to afflict 3-20% of the population. Risk of olfactory dysfunction increases with old age and may also result from chronic sinonasal diseases, severe head trauma, and upper respiratory infections, or neurodegenerative diseases. These disorders impair the ability to sense warning odors in foods and the environment, as well as hinder the quality of life related to social interactions, eating, and feelings of well-being. This article reports and extends on a clinical update commencing at the 2016 Association for Chemoreception Sciences annual meeting...
May 22, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28531279/mechanisms-governing-inflammasome-activation-assembly-and-pyroptosis-induction
#7
Sannula Kesavardhana, Thirumala-Devi Kanneganti
Inflammasomes are multimeric protein complexes that regulate inflammatory responses and pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition receptors such as nucleotide-binding domain and leucine-rich repeat receptors (NLRs) and absent in melanoma 2 like receptors (ALRs) assemble the inflammasome complexes in response to pathogens and danger or altered-self signals in the cell. Inflammasome sensors, in association with an adaptor protein - apoptosis associated speck-like protein containing a caspase-activation and -recruitment domain (ASC) - activate inflammatory caspase-1 to enable the release of inflammatory cytokines and induce cell death, conferring host defense against pathogens...
May 20, 2017: International Immunology
https://www.readbyqxmd.com/read/28531184/bacarena-individual-based-metabolic-modeling-of-heterogeneous-microbes-in-complex-communities
#8
Eugen Bauer, Johannes Zimmermann, Federico Baldini, Ines Thiele, Christoph Kaleta
Recent advances focusing on the metabolic interactions within and between cellular populations have emphasized the importance of microbial communities for human health. Constraint-based modeling, with flux balance analysis in particular, has been established as a key approach for studying microbial metabolism, whereas individual-based modeling has been commonly used to study complex dynamics between interacting organisms. In this study, we combine both techniques into the R package BacArena (https://cran.r-project...
May 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28531174/genome-partitioner-a-web-tool-for-multi-level-partitioning-of-large-scale-dna-constructs-for-synthetic-biology-applications
#9
Matthias Christen, Luca Del Medico, Heinz Christen, Beat Christen
Recent advances in lower-cost DNA synthesis techniques have enabled new innovations in the field of synthetic biology. Still, efficient design and higher-order assembly of genome-scale DNA constructs remains a labor-intensive process. Given the complexity, computer assisted design tools that fragment large DNA sequences into fabricable DNA blocks are needed to pave the way towards streamlined assembly of biological systems. Here, we present the Genome Partitioner software implemented as a web-based interface that permits multi-level partitioning of genome-scale DNA designs...
2017: PloS One
https://www.readbyqxmd.com/read/28531167/a-role-for-the-host-dna-damage-response-in-hepatitis-b-virus-cccdna-formation-and-beyond
#10
REVIEW
Sabrina Schreiner, Michael Nassal
Chronic hepatitis B virus (HBV) infection puts more than 250 million people at a greatly increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates via protein-primed reverse transcription of a pregenomic (pg) RNA, yielding an unusually structured, viral polymerase-linked relaxed-circular (RC) DNA as genome in infectious particles. Upon infection, RC-DNA is converted into nuclear covalently closed circular (ccc) DNA. Associating with cellular proteins into an episomal minichromosome, cccDNA acts as template for new viral RNAs, ensuring formation of progeny virions...
May 22, 2017: Viruses
https://www.readbyqxmd.com/read/28531163/applications-of-gold-nanoparticles-in-nanomedicine-recent-advances-in-vaccines
#11
REVIEW
Sónia Alexandra Correia Carabineiro
Nowadays, gold is used in (nano-)medicine, usually in the form of nanoparticles, due to the solid proofs given of its therapeutic effects on several diseases. Gold also plays an important role in the vaccine field as an adjuvant and a carrier, reducing toxicity, enhancing immunogenic activity, and providing stability in storage. An even brighter golden future is expected for gold applications in this area.
May 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530745/self-assembling-peptide-and-protein-amyloids-from-structure-to-tailored-function-in-nanotechnology
#12
REVIEW
Gang Wei, Zhiqiang Su, Nicholas P Reynolds, Paolo Arosio, Ian W Hamley, Ehud Gazit, Raffaele Mezzenga
Self-assembled peptide and protein amyloid nanostructures have traditionally been considered only as pathological aggregates implicated in human neurodegenerative diseases. In more recent times, these nanostructures have found interesting applications as advanced materials in biomedicine, tissue engineering, renewable energy, environmental science, nanotechnology and material science, to name only a few fields. In all these applications, the final function depends on: (i) the specific mechanisms of protein aggregation, (ii) the hierarchical structure of the protein and peptide amyloids from the atomistic to mesoscopic length scales and (iii) the physical properties of the amyloids in the context of their surrounding environment (biological or artificial)...
May 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28530724/phase-transition-and-in-situ-construction-of-lateral-heterostructure-of-2d-superconducting-%C3%AE-%C3%AE-mo2c-with-sharp-interface-by-electron-beam-irradiation
#13
Zhibo Liu, Zeyuan Fei, Chuan Xu, Yixiao Jiang, Xiu-Liang Ma, Hui-Ming Cheng, Wencai Ren
Lateral heterostructures of 2D materials have several interesting properties and potential applications, and they are usually fabricated by chemical vapor deposition. However, it still remains a great challenge to fabricate 2D lateral heterostructures with well-controlled patterns and sharp interfaces. Herein, we found that the 2D α-Mo2C crystal, a recently emerging 2D superconductor, experiences a phase transition from the α phase to β phase on electron beam irradiation in a transmission electron microscope because of the migration of carbon atoms among the molybdenum octahedrons...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28530648/mechanism-of-human-somatic-reprogramming-to-ips-cell
#14
Rika Teshigawara, Junkwon Cho, Masahiro Kameda, Takashi Tada
Somatic reprogramming to induced pluripotent stem cells (iPSC) was realized in the year 2006 in mice, and in 2007 in humans, by transiently forced expression of a combination of exogenous transcription factors. Human and mouse iPSCs are distinctly reprogrammed into a 'primed' and a 'naïve' state, respectively. In the last decade, puzzle pieces of somatic reprogramming have been collected with difficulty. Collectively, dissecting reprogramming events and identification of the hallmark of sequentially activated/silenced genes have revealed mouse somatic reprogramming in fragments, but there is a long way to go toward understanding the molecular mechanisms of human somatic reprogramming, even with developing technologies...
May 22, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28530647/stage-of-liver-fibrosis-in-patients-with-congenital-bleeding-disorders-and-infected-with-hepatitis-c-virus
#15
Marta Kucharska, Urszula Zaleska-Dorobisz, Aleksandra Szymczak, Marcin Inglot, Weronika Rymer, Małgorzata Zalewska, Krzysztof Małyszczak, Małgorzata Kuliszkiewicz-Janus, Małgorzata Inglot
INTRODUCTION    Hepatitis C virus (HCV) is the major cause of chronic liver disease in patients with hemophilia. As liver biopsy should not be routinely used in them, possibilities of accurate assessment of the fibrosis stage have been very limited until recently. OBJECTIVES    The aim of the study was to determine the stage of liver fibrosis in HCV-infected hemophiliacs with use of non-invasive methods of fibrosis assessment and to analyze the influence of risk factors on liver fibrosis.  PATIENTS AND METHODS    The study included 71 HCV-infected patients with hemophilia and other congenital bleeding disorders...
May 22, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28530501/palliative-care-for-advanced-heart-failure-in-a-department-of-veterans-affairs-regional-hospice-program-patient-selection-a-treatment-protocol-and-clinical-course
#16
George J Taylor, Dorothy M Lee, Catalin F Baicu, Michael R Zile
BACKGROUND: Palliative care for advanced heart failure (HF) is generally recommended. However, few reports have focused on the particulars of treatment, or the clinical course of HF on a specific treatment regimen. OBJECTIVE: Palliation adequate to allow patients to avoid HF admission and die at home. METHODS: Patients from a veterans administration regional practice with multiple, recent hospital admissions were enrolled in community hospice programs...
May 22, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28530146/an-emerging-integration-between-ionic-liquids-and-nanotechnology-general-uses-and-future-prospects-in-drug-delivery
#17
Tânia Santos de Almeida, Ana Júlio, Joana Portugal Mota, Patrícia Rijo, Catarina Pinto Reis
There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530076/-osteoporosis-and-diabetes-in-which-way-are-they-related
#18
REVIEW
Osnat Tell-Lebanon, Pnina Rotman-Pikielny
Diabetes and osteoporosis are common diseases with growing prevalence in the aging population. Many recent studies have reported an association between diabetes mellitus and an increased osteoporotic fracture rate. Compared to control subjects, decreased bone mineral density has been observed in patients with type 1 diabetes mellitus, while those with type 2 diabetes display a unique skeletal phenotype of increased bone mineral density, but impaired architectural structure and mineral properties. Accumulation of advanced glycation end products changes collagen structure and suppression of bone turnover causes impairment of repair and adaptation mechanisms...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28530050/-modern-over-the-good-and-old
#19
Sharon Baum, Aviv Barzilai
Modern dermatology is a reflection of the advances achieved in the general medical world. Thus, in recent years, dermatology encompasses many different fields and consequently, various subspecialties were created. In addition to dermatopathology and dermatosurgery, which are formal subspecialties, other fields of expertise include: autoimmune diseases, especially bullous diseases, hair and nail disorders, allergic diseases, infectious diseases and pigmented lesion clinics and oncodermatology. This current issue of "Harefuah" incorporates research and review articles from experts of the different subspecialties mentioned...
October 2016: Harefuah
https://www.readbyqxmd.com/read/28529952/advancements-in-developing-strategies-for-sterilizing-and-functional-hiv-cures
#20
REVIEW
Wei Xu, Haoyang Li, Qian Wang, Chen Hua, Hanzhen Zhang, Weihua Li, Shibo Jiang, Lu Lu
Combined antiretroviral therapy (cART) has been successful in prolonging lifespan and reducing mortality of patients infected with human immunodeficiency virus (HIV). However, the eradication of latent HIV reservoirs remains a challenge for curing HIV infection (HIV cure) because of HIV latency in primary memory CD4(+) T cells. Currently, two types of HIV cures are in development: a "sterilizing cure" and a "functional cure." A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without treatment...
2017: BioMed Research International
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