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https://www.readbyqxmd.com/read/29924910/differentiating-antiproliferative-and-chemopreventive-modes-of-activity-for-electron-deficient-aryl-isothiocyanates-against-human-mcf-7-cells
#1
Ruthellen H Anderson, Cody J Lensing, Benjamin J Forred, Michael W Amolins, Cassandra L Aegerter, Peter F Vitiello, Jared R Mays
Consumption of Brassica vegetables provides beneficial effects due to organic isothiocyanates (ITCs), a resultant product of the enzymatic hydrolysis of glucosinolate secondary metabolites. The ITC L-sulforaphane (L-SFN) is the principle agent in broccoli that demonstrates several modes of anticancer action. While the anticancer properties of ITCs like L-SFN have been extensively studied and L-SFN has been the subject of multiple human clinical trials, the scope of this work has largely been limited to those derivatives found in nature...
June 20, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29923573/sensory-acceptable-equivalent-doses-of-%C3%AE-phenylethyl-isothiocyanate-peitc-induce-cell-cycle-arrest-and-retard-the-growth-of-p53-mutated-oral-cancer-in-vitro-and-in-vivo
#2
Aroonwan Lam-Ubol, Alison Lea Fitzgerald, Arnat Ritdej, Tawaree Phonyiam, Hui Zhang, Jeffrey N Myers, Peng Huang, Dunyaporn Trachootham
High doses of β-phenylethyl isothiocyanate (PEITC), a phytochemical in cruciferous vegetables, are not feasible for consumption due to a strong mouth-tingling effect. This study investigated the anti-cancer effect of PEITC at sensory acceptable doses. In vitro, PEITC was selectively toxic to oral cancer cells (CAL-27, FaDu, SCC4, SCC 9, SCC15, SCC25 and TU138), compared to oral keratinocytes (OKF6/TERT2 and NOK/Si). In vivo, 5 and 10 mg kg-1 PEITC, equivalent to human organoleptically acceptable doses, retarded tumor growth and prolonged the survival of mice bearing p53-mutated oral cancer cells - TU138 xenograft...
June 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29923480/the-japanese-food-score-and-risk-of-all-cause-cvd-and-cancer-mortality-the-japan-collaborative-cohort-study
#3
Emiko Okada, Koshi Nakamura, Shigekazu Ukawa, Kenji Wakai, Chigusa Date, Hiroyasu Iso, Akiko Tamakoshi
Few studies have reported the association between the Japanese diet as food score and mortality. This study aimed to investigate adherence to the Japanese food score associated with all-cause, CVD and cancer mortality. A total of 58 767 (23 162 men and 34 232 women) Japanese participants aged 40-79 years, who enrolled in the Japan Collaborative Cohort Study between 1988 and 1990, were included. The Japanese food score was derived from the components of seven food groups (beans and bean products, fresh fishes, vegetables, Japanese pickles, fungi, seaweeds and fruits) based on the FFQ...
June 20, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29916532/resveratrol-induced-reactive-oxygen-species-and-endoplasmic-reticulum-stress%C3%A2-mediated-apoptosis-and-cell-cycle-arrest-in-the-a375sm-malignant-melanoma-cell-line
#4
Jae-Rim Heo, Soo-Min Kim, Kyung-A Hwang, Ji-Houn Kang, Kyung-Chul Choi
Resveratrol, a dietary product present in grapes, vegetables and berries, regulates several signaling pathways that control cell division, cell growth, apoptosis and metastasis. Malignant melanoma proliferates more readily in comparison with any other types of skin cancer. In the present study, the anti‑cancer effect of resveratrol on melanoma cell proliferation was evaluated. Treating A375SM cells with resveratrol resulted in a decrease in cell growth. The alteration in the levels of cell cycle‑associated proteins was also examined by western blot analysis...
June 15, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29915949/dietary-supplements-and-fatigue-in-patients-with-breast-cancer-a-systematic-review
#5
REVIEW
Paula Tâmara Vieira Teixeira Pereira, Andréa Dias Reis, Renata Rodrigues Diniz, Franciléia Andrade Lima, Richard Diego Leite, Mayara Cristina Pinto da Silva, Rosane Nassar Meireles Guerra, Érica Brandão de Moraes Vieira, João Batista Santos Garcia
PURPOSE: Cancer-related fatigue (CRF) is defined as a distressing, persistent, and subjective sense of physical or emotional and/or cognitive exhaustion. The treatment of CRF includes pharmacological and non-pharmacological therapies; dietary strategies with promising results have also been used. This study aimed to identify dietary supplements that improve fatigue in patients with breast cancer. METHODS: A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29909173/the-effect-of-flavor-content-in-e-liquids-on-e-cigarette-emissions-of-carbonyl-compounds
#6
Yao Qu, Ki-Hyun Kim, Jan E Szulejko
The effect of flavors on carbonyl compound (CC) emission factors (EF) from electronic cigarettes (ECs) vaping was investigated at the default vaping (voltage) setting in all experiments using a total of 21 lab-made e-liquid samples (five different types of retail flavorant bases: beverage/dessert/fruit/mint/tobacco). Each flavorant base was added to a separate unflavored base composed of a 1:1 mixture of propylene glycol/vegetable glycerol (PG/VG) at four levels (5/10/30/50% (v/v)). The e-liquid CC levels increased linearly with flavorant base content, 1...
June 14, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908499/characterization-of-polycyclic-aromatic-hydrocarbons-pahs-in-vegetables-near-industrial-areas-of-shanghai-china-sources-exposure-and-cancer-risk
#7
Jinpu Jia, Chunjuan Bi, Junfeng Zhang, Xiaopei Jin, Zhenlou Chen
Dietary consumption of contaminated vegetables may contribute to polycyclic aromatic hydrocarbon (PAH) exposure in humans; however, this exposure pathway has not been examined thoroughly. This study aims to characterize the concentrations of PAHs in six types of vegetables grown near industrial facilities in Shanghai, China. We analyzed 16 individual PAHs on the US EPA priority list, and the total concentration in vegetables ranged from 65.7 to 458.0 ng g-1 in the following order: leafy vegetables (romaine lettuce, Chinese cabbage and Shanghai green cabbage) > stem vegetables (lettuce) > seed and pod vegetables (broad bean) > rhizome vegetables (daikon)...
June 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29904989/psychosocial-mediators-of-dietary-change-among-hispanic-latina-breast-cancer-survivors-in-a-culturally-tailored-dietary-intervention
#8
Zaixing Shi, John M Richardson, A Corina Aycinena, Heewon L Gray, Rachel Paul, Pam Koch, Isobel Contento, Ann Ogden Gaffney, Heather Greenlee
OBJECTIVE: To examine psychosocial mediators of the effect of a culturally-tailored dietary intervention on dietary change among Hispanic/Latina breast cancer survivors. METHODS: Hispanic/Latina breast cancer survivors (n=70) were randomized to receive either a 12-week theory- and culturally-tailored dietary change program (intervention group, n=34), or standard-of-care printed recommendations (control group, n=36) (ClinicalTrials.gov NCT01414062). Fruit/vegetable intake (F/V), % calories from fat, and hypothesized psychosocial mediators were assessed at baseline, 6 and 12-months...
June 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29904587/indole-3-carbinol-a-plant-hormone-combatting-cancer
#9
REVIEW
Ella Katz, Sophia Nisani, Daniel A Chamovitz
A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been considered healthy, and various epidemiological studies suggest that the consumption of cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain a vast array of phytochemicals, the mechanism by which these vegetables counteract cancer is still largely unresolved. Numerous in situ studies have implicated indole-3-carbinol, a breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phytochemicals with anti-cancer properties...
2018: F1000Research
https://www.readbyqxmd.com/read/29899271/the-effects-of-combinatorial-genistein-and-sulforaphane-in-breast-tumor-inhibition-role-in-epigenetic-regulation
#10
Bidisha Paul, Yuanyuan Li, Trygve O Tollefsbol
Dietary compounds that possess the properties of altering epigenetic processes are gaining popularity as targets for cancer prevention studies. These compounds when administered at optimal concentrations and especially in combination can have enhanced effects in cancer prevention or therapy. It is important to study the interaction of two or more compounds in order to assess their role in enhancing prevention. Genistein (GEN), found in soy, has been extensively studied for its role as an epigenetic modifier especially as a DNA methyltransferase (DNMT) inhibitor and sulforaphane (SFN), found in cruciferous vegetables, is known as a histone deacetylase (HDAC) inhibitor...
June 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29895577/marantic-endocarditis-incidental-infarcts-leading-to-diagnosis-of-pancreatic-cancer
#11
Ella Starobinska, Eric A Robinson, Eric Brucks, Serena Scott
Non-bacterial thrombotic endocarditis (NBTE) is a well-described phenomenon associated with malignancies due to hypercoaguable state. In the setting of pancreatic cancer, NBTE is more commonly diagnosed postmortem. We describe a case of a man who was diagnosed with pancreatic carcinoma after incidental finding of NBTE. Imaging incidentally revealed multiple strokes, bilateral renal and splenic infarcts, while subsequent workup for cardioembolic source demonstrated a 1.1×0.7 cm mitral valve vegetation. As multiple blood cultures were sterile and patient lacked clinical signs of infection, an underlying malignancy was suspected...
June 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29890115/from-chemo-prevention-to-epigenetic-regulation-the-role-of-isothiocyanates-in-skin-cancer-prevention
#12
REVIEW
Melina Mitsiogianni, Tom Amery, Rodrigo Franco, Vasilis Zoumpourlis, Aglaia Pappa, Mihalis I Panayiotidis
Skin cancer incidence is rapidly growing over the last decades and is generally divided into malignant melanoma and non-melanoma (NMSC) with the latter being subdivided into squamous (SCC) and basal cell carcinoma (BCC). Among them, melanoma is the most aggressive type with high mortality rates. On the other hand, aberrant gene expression is a critical step towards malignant transformation. To this end, epigenetic modifications like changes in DNA methylation patterns and miRNA expression profile as well as histone modifications are all capable of inducing an altered gene expression profile involved in various cellular cascades including cell cycle, proliferation and apoptosis...
June 8, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29885291/carotenoids-in-human-nutrition-and-health
#13
REVIEW
Manfred Eggersdorfer, Adrian Wyss
Carotenoids are naturally occurring pigments found in most fruits and vegetables, plants, algae, and photosynthetic bacteria. Humans cannot synthesize carotenoids and must ingest them in food or via supplementation. Carotenoids have a range of functions in human health. They primarily exert antioxidant effects, but individual carotenoids may also act through other mechanisms; for example, β-carotene has a pro-vitamin A function, while lutein/zeaxanthin constitute macular pigment in the eye. The benefit of lutein in reducing progression of age-related macular eye disease and cataracts is strengthening; an intake recommendation would help to generate awareness in the general population to have an adequate intake of lutein rich foods...
June 6, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29884153/outdoor-air-pollution-green-space-and-cancer-incidence-in-saxony-a-semi-individual-cohort-study
#14
Thomas Datzmann, Iana Markevych, Freya Trautmann, Joachim Heinrich, Jochen Schmitt, Falko Tesch
BACKGROUND: There are a few epidemiological studies that (1) link increased ambient air pollution (AP) with an increase in lung cancer incidence rates and (2) investigate whether residing in green spaces could be protective against cancer. However, it is completely unclear whether other forms of cancer are also affected by AP and if residential green spaces could lower cancer incidence rates in general. Therefore, the objective was to estimate whether AP and green space are associated with several cancer types...
June 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29882783/structure%C3%A2-activity-relationship-and-molecular-docking-of-natural-product-library-reveal-chrysin-as-a-novel-dipeptidyl-peptidase-4-dpp-4-inhibitor-an-integrated-in-silico-and-in-vitro-study
#15
Poonam Kalhotra, Veera C S R Chittepu, Guillermo Osorio-Revilla, Tzayhri Gallardo-Velázquez
Numerous studies indicate that diets with a variety of fruits and vegetables decrease the incidence of severe diseases, like diabetes, obesity, and cancer. Diets contain a variety of bioactive compounds, and their features, like diverge scaffolds, and structural complexity make them the most successful source of potential leads or hits in the process of drug discovery and drug development. Recently, novel serine protease dipeptidyl peptidase-4 (DPP-4) inhibitors played a role in the management of diabetes, obesity, and cancer...
June 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29879413/antiproliferative-effect-of-p-coumaric-acid-targets-upr-activation-by-downregulating-grp78-in-colon-cancer
#16
Sharada H Sharma, Vinothkumar Rajamanickam, Sangeetha Nagarajan
p-CA is a naturally occurring phenolic acid present in most plants and in all commonly consumed vegetables and fruits. Here we demonstrated the anti-cancer effect of the food borne phytochemical p-CA both in vitro and in vivo models of colon cancer using growth rate and tumor incidence as endpoints. Glucose regulated protein (GRP78) induction and UPR activation plays a key role in oncogenic progression, therefore increased dependence of cancer cells on these UPR signaling pathways for survival can be exploited for anti-cancer research...
June 4, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29867803/shifts-on-gut-microbiota-associated-to-mediterranean-diet-adherence-and-specific-dietary-intakes-on-general-adult-population
#17
Izaskun Garcia-Mantrana, Marta Selma-Royo, Cristina Alcantara, María C Collado
There is increasing evidence for the interaction between gut microbiome, diet, and health. It is known that dysbiosis is related to disease and that most of the times this imbalances in gut microbial populations can be promoted through diet. Western dietary habits, which are characterized by high intakes of calories, animal proteins, saturated fats, and simple sugars have been linked with higher risk of obesity, diabetes, cancer, and cardiovascular disease. However, little is known about the impact of dietary patterns, dietary components, and nutrients on gut microbiota in healthy people...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29866056/effects-of-indole-3-carbinol-on-steroid-hormone-profile-and-tumor-progression-in-a-mice-model-of-canine-inflammatory-mammarycancer
#18
Asunción Martín-Ruiz, Laura Peña, Alfredo González-Gil, Lucía Teresa Díez-Córdova, Sara Cáceres, Juan Carlos Illera
BACKGROUND: Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or canine inflammatory mammary cancer that is the most aggressive type of breast cancer. METHODS: The aim of this study was to analyze the effect of indole-3-carbinol on a SCID mice xenograft model of canine inflammatory mammary cancer, using equivalent human oral dose as a preventive therapy in humans for 3 weeks...
June 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29861829/non-provitamin-a-and-provitamin-a-carotenoids-as-immunomodulators-recommended-dietary-allowance-therapeutic-index-or-personalized-nutrition
#19
REVIEW
Elisabetta Toti, C-Y Oliver Chen, Maura Palmery, Débora Villaño Valencia, Ilaria Peluso
Vegetables and fruits contain non-provitamin A (lycopene, lutein, and zeaxanthin) and provitamin A ( β -carotene, β -cryptoxanthin, and α -carotene) carotenoids. Within these compounds, β -carotene has been extensively studied for its health benefits, but its supplementation at doses higher than recommended intakes induces adverse effects. β -Carotene is converted to retinoic acid (RA), a well-known immunomodulatory molecule. Human interventions suggest that β -carotene and lycopene at pharmacological doses affect immune functions after a depletion period of low carotenoid diet...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29848915/-regional-differences-in-mortality-and-food-and-nutrient-intake-and-their-associations-among-secondary-healthcare-service-areas-in-hokkaido
#20
Tomoko Kishi, Emiko Okada, Atsuko Sato, Masako Ishikawa, Shigekazu Ukawa, Koshi Nakamura, Akiko Tamakoshi
Objective Hokkaido is a geographically vast area comprising a variety of natural environments and major industries. Therefore, we presume that there are large differences in lifestyles and lifestyle-related disease mortality in community people based on region. The aim of this study was to investigate the regional differences in mortality and food and nutrient intake, and their associations among secondary healthcare service areas in Hokkaido.Methods This study's design was ecological. We collected mortality data using public health statistics from the year 2005 to 2009 of the Hokkaido prefecture...
2018: [Nihon Kōshū Eisei Zasshi] Japanese Journal of Public Health
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