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https://www.readbyqxmd.com/read/29457582/green-leafy-and-cruciferous-vegetable-consumption-and-risk-of-type-2-diabetes-results-from-the-singapore-chinese-health-study-and-meta-analysis
#1
Guo-Chong Chen, Woon-Puay Koh, Jian-Min Yuan, Li-Qiang Qin, Rob M van Dam
Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews...
February 19, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29455692/a-non-invasive-assessment-of-skin-carotenoid-status-through-reflection-spectroscopy-is-a-feasible-reliable-and-potentially-valid-measure-of-fruit-and-vegetable-consumption-in-a-diverse-community-sample
#2
Stephanie Bell Jilcott Pitts, Lisa Jahns, Qiang Wu, Nancy E Moran, Ronny A Bell, Kimberly P Truesdale, Melissa N Laska
OBJECTIVE: To assess the feasibility, reliability and validity of reflection spectroscopy (RS) to assess skin carotenoids in a racially diverse sample. DESIGN: Study 1 was a cross-sectional study of corner store customers (n 479) who completed the National Cancer Institute Fruit and Vegetable Screener as well as RS measures. Feasibility was assessed by examining the time it took to complete three RS measures, reliability was assessed by examining the variation between three RS measures, and validity was examined by correlation with self-reported fruit and vegetable consumption...
February 19, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29451459/apiaceous-vegetables-and-cruciferous-phytochemicals-reduced-phip-dna-adducts-in-prostate-but-not-in-pancreas-of-wistar-rats
#3
Jae Kyeom Kim, Marissa A McCormick, Cynthia M Gallaher, Daniel D Gallaher, Sabrina P Trudo
We previously showed rats fed with apiaceous vegetables, but not with their putative chemopreventive phytochemicals, reduced colonic DNA adducts formed by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary procarcinogen. We report here the effects of feeding apiaceous and cruciferous vegetables versus their purified predominant phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adduct formation. In experiment I, male Wistar rats received three supplemented diets: CRU (cruciferous vegetables), API (apiaceous vegetables), and CRU+API (both types of vegetables)...
February 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29451351/delphinidin-induces-apoptosis-and-inhibits-epithelial-to-mesenchymal-transition-via-the-erk-p38-mapk-signaling-pathway-in-human-osteosarcoma-cell-lines
#4
Hae-Mi Kang, Bong-Soo Park, Hyun-Kyung Kang, Hae-Ryoun Park, Su-Bin Yu, In-Ryoung Kim
Delphinidin is major anthocyanidin that is extracted from many pigmented fruits and vegetables. This substance has anti-oxidant, anti-inflammatory, anti-angiogenic, and anti-cancer properties. In addition, delphinidin strongly suppresses the migration and invasion of various cancer cells during tumorigenesis. Although delphinidin has anti-cancer effects, little is known about its functional roles in osteosarcoma (OS). For these reasons, we have demonstrated the effects of delphinidin on OS cell lines. The effects of delphinidin on cell viability and growth of OS cells were assessed using the MTT assay and colony formation assays...
February 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29446005/assessing-oral-cancer-awareness-among-dental-students
#5
Gaye Keser, Filiz Namdar Pekiner
The aim of this study was to assess oral cancer awareness among undergraduate dental students in Marmara University Faculty of Dentistry. A validated questionnaire which tested oral cancer awareness was given to third- and fifth-year students of the dental faculty of Marmara University. A total of 198 students participated in this survey. Knowledge of oral cancer risk factors and diagnosis procedures, dentistry student's attitude towards oral cancers, management practice regarding oral cancer, and oral cancer information sources were assessed using 25 questions...
February 14, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29442457/dietary-patterns-and-breast-or-lung-cancer-risk-a-pooled-analysis-of-2-case-control-studies-in-north-eastern-poland
#6
Beata Krusińska, Iwona Hawrysz, Małgorzata A Słowińska, Lidia Wądołowska, Maciej Biernacki, Anna Czerwińska, Janusz J Gołota
BACKGROUND: Breast cancer in women and lung cancer in men are the most prevalent cancers in Poland and worldwide. Evidence of the impact of food groups and nutrients on the risk of breast and lung cancer is limited and lacking conclusions. Studies on food consumption and breast or lung cancer are limited. OBJECTIVES: Assessment of the association between dietary patterns and the prevalence of breast and lung cancers in adult Poles. MATERIAL AND METHODS: The study involved a pooled analysis of 2 case-control studies on 320 subjects aged 50-70 years from north-eastern Poland (160 women, 160 men)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29436100/lupeol-alters-er-stress-signaling-pathway-by-downregulating-abcg2-expression-to-induce-oxaliplatin-resistant-lovo-colorectal-cancer-cell-apoptosis
#7
Ming-Cheng Chen, Hsi-Hsien Hsu, Yuan-Yuan Chu, Sue-Fei Cheng, Chia-Yao Shen, Yi-Jiun Lin, Ray-Jade Chen, Vijaya Padma Viswanadha, Yueh-Min Lin, Chih-Yang Huang
Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However, cancer cells commonly acquire multidrug resistance (MDR), which is a major obstruction to cancer treatment. Recent studies have shown that natural components from traditional Chinese medicine or foods that have many biological functions may be new adjuvant therapies in clinical trials...
February 13, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29433825/risk-factors-for-prostate-cancer-a-multifactorial-case-control-study
#8
Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multifactorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case-control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010-2015) and 900 age matched controls. Odds ratio (OR) and 95% CI were used to estimate the association between different risk factors and prostate cancer...
February 9, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29433784/do-cancer-patients-change-their-diet-in-the-e-health-information-era-a-review-of-the-literature-and-a-survey-as-a-proposal-for-the-italian-population
#9
F Ghelfi, M Tieri, S Gori, F Nicolis, M C Petrella, A Filiberti, G Apolone, L Titta
In recent years, there has been an explosion in the amount of available information on cancer in parallel with an ever-increasing number of cancer survivors. Cancer patients and long-term survivors are known to be more sensitive to health-related information and dietary changes could represent a potential consequence of this huge availability of messages. In our review about dietary changes after cancer diagnosis, we found that this topic is particularly investigated among the breast cancer population. The literature examined show that breast cancer patients modify their eating habits after diagnosis in a percentage that varies between approximately 30% and 60%...
February 2018: Food Research International
https://www.readbyqxmd.com/read/29433671/phytochemical-induced-reactive-oxygen-species-and-endoplasmic-reticulum-stress-mediated-apoptosis-and-differentiation-in-malignant-melanoma-cells
#10
Jae-Rim Heo, Geum-A Lee, Gyu-Sik Kim, Kyung-A Hwang, Kyung-Chul Choi
BACKGROUND: Phytochemicals are derived from plants, vegetables and daily products and exert chemopreventive effects. Malignant melanoma is highly metastatic, and melanoma patients can develop chemotherapeutic resistance against conventional melanoma therapies. METHODS: In the present study, we investigated the anti-cancer effect of the phytochemicals kaempferol (Kaem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability. We also evaluated the altered expression of cell cycle-related genes...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29426230/lifestyle-and-dietary-factors-and-prostate-cancer-risk-a-multicentre-case-control-study
#11
Mohammad Al Qadire, Murad Alkhalaileh, Mohammed ALBashtawy
This study aims to explore the association between fruit and vegetable intake, high fat, body mass index (BMI) score, physical activity, and the occurrence of prostate cancer among Jordanian men. A case-control study was conducted in three large referral hospitals. The sample included 165 prostate cancer patients in the case group and 177 healthy participants in the control group. The results showed that smoking (odds ratio [OR] = 0.32; 95% confidence interval [CI] = [0.18, 0.57]), a history of prostate infection (OR = 0...
February 1, 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29425784/the-reach-of-human-health-risks-associated-with-metals-metalloids-in-water-and-vegetables-along-a-contaminated-river-catchment-south-africa-and-mozambique
#12
Bettina Genthe, Thandi Kapwata, Wouter Le Roux, Jessica Chamier, Caradee Y Wright
BACKGROUND: Anthropogenic pollution was identified as an environmental problem of concern when, in 2008, dozens of crocodiles died in the Olifants River catchment near the border of South Africa and Mozambique. Given the close proximity of households to the river and their making use of river water, we aimed to determine to what extent water pollution has an impact on health of indigent communities in South Africa and Mozambique in the catchment area. METHODS: Water and vegetable samples were collected from the study areas...
February 1, 2018: Chemosphere
https://www.readbyqxmd.com/read/29412795/a-new-target-for-the-treatment-of-endometrium-cancer-by-succinic-acid
#13
Elif Sinem Iplik, Tolga Catmakas, Bedia Cakmakoglu
Endometrium cancer is the most common invasive gynecologic malignancy in developed countries. Succinic acid (CO2HCH2-CH2CO2H) is a type of dibasic acid that has uncolored crystal. Succinic acid is used in bakery products and aromatized products. It is naturally found in some vegetables. Succinic acid has no adverse effects because it is metabolized by body cells and has a role in the tricarboxylic acid cycle (TCA) as a cycle media component. The TCA cycle and its enzyme components have some crucial roles for basal cell metabolism...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29406335/fish-shellfish-intake-and-the-risk-of-head-and-neck-cancer
#14
Kathleen M McClain, Patrick T Bradshaw, Nikhil K Khankari, Marilie D Gammon, Andrew F Olshan
Fish intake and other dietary sources of omega-3 fatty acids have been shown to be associated with a reduced risk for some cancers. Although previous studies of head and neck cancer have reported associations with different dietary factors, including reduced risks for fruits and vegetables and putatively healthy dietary patterns, associations specific to fish intake are unclear. This study investigated the association between fish/shellfish intake and risk of squamous cell carcinoma of the head and neck (SCCHN) using data from the Carolina Head and Neck Cancer Epidemiology Study, a population-based case-control study conducted in 46 North Carolina counties with cases recruited from 2002 through 2006...
February 5, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29401293/fruit-and-vegetable-consumption-and-risk-of-endometriosis
#15
H R Harris, A C Eke, J E Chavarro, S A Missmer
STUDY QUESTION: Is there an association between intake of fruits and vegetables and risk of laparoscopically confirmed endometriosis? SUMMARY ANSWER: Higher intake of fruits, particularly citrus fruits, is associated with a lower risk of endometriosis. WHAT IS KNOWN ALREADY: Two case-control studies have examined the associations between fruit and vegetable intake and endometriosis risk with contrasting results. Diets rich in fruits and vegetables include higher levels of pro-vitamin A nutrients (alpha-carotene, beta-carotene, beta-cryptoxanthin) and women with endometriosis have been reported to have lower intake of vitamin A than women without endometriosis...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29399439/plant-flavone-apigenin-an-emerging-anticancer-agent
#16
Eswar Shankar, Aditi Goel, Karishma Gupta, Sanjay Gupta
Research in cancer chemoprevention provides convincing evidence that increased intake of vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals present therein provide beneficial anti-inflammatory and antioxidant properties that serve to improve the cellular microenvironment. Compounds known as flavonoids categorized anthocyanidins, flavonols, flavanones, flavonols, flavones, and isoflavones have shown considerable promise as chemopreventive agents. Apigenin (4', 5, 7-trihydroxyflavone), a major plant flavone, possessing antioxidant, anti-inflammatory, and anticancer properties affecting several molecular and cellular targets used to treat various human diseases...
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29399003/dietary-patterns-and-colorectal-cancer-risk-a-review-of-17-years-of-evidence-2000-2016
#17
Fred K Tabung, Lisa S Brown, Teresa T Fung
Purpose of review: Colorectal cancer (CRC) is a global public health problem, with an estimated 1.4 million cases diagnosed worldwide in 2012. Evidence suggests that diet may be important for primary prevention. Recent findings: The 2017 WCRF/AICR Continuous Update Project on colorectal cancer concluded that there is convincing evidence linking several individual dietary factors with CRC risk but the evidence for dietary patterns was limited and inconclusive. Also, previous reviews and meta-analyses have not critically synthesized various dietary patterns...
December 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/29393400/%C3%AE-%C3%A2-carotene-reverses-tobacco-smoke%C3%A2-induced-gastric-emt-via-notch-pathway-in-vivo
#18
Ling Lu, Jia Chen, Manli Li, Ling Tang, Rui Wu, Longtao Jin, Zhaofeng Liang
Tobacco smoke is one of the serious risk factors of gastric cancer. Epithelial‑mesenchymal transition (EMT) has been shown to be associated with the initiation and carcinogenesis of gastric cancer. The role of Notch pathway in regulating tobacco smoke-induced EMT has not been investigated. β‑carotene, a carotenoid present in fruits, vegetables and rice, suppresses cancer progression. In this investigation, we evaluated the regulatory role of Notch pathway in tobacco smoke‑mediated gastric EMT and the preventive effect of β‑carotene using a BALB/c mouse smoking model...
February 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29391428/%C3%AE-sitosterol-targets-trx-trx1-reductase-to-induce-apoptosis-in-a549-cells-via-ros-mediated-mitochondrial-dysregulation-and-p53-activation
#19
Tamilselvam Rajavel, Pandian Packiyaraj, Venkatesan Suryanarayanan, Sanjeev Kumar Singh, Kandasamy Ruckmani, Kasi Pandima Devi
β-Sitosterol (BS), a major bioactive constituent present in plants and vegetables has shown potent anticancer effect against many human cancer cells, but the underlying mechanism remain elusive on NSCLC cancers. We found that BS significantly inhibited the growth of A549 cells without harming normal human lung and PBMC cells. Further, BS treatment triggered apoptosis via ROS mediated mitochondrial dysregulation as evidenced by caspase-3 & 9 activation, Annexin-V/PI positive cells, PARP inactivation, loss of MMP, Bcl-2-Bax ratio alteration and cytochrome c release...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29390118/differences-among-thai-agricultural-workers-health-working-conditions-and-pesticide-use-by-farm-type
#20
Pornpimol Kongtip, Noppanun Nankongnab, Redeerat Mahaboonpeeti, Sasivimol Bootsikeaw, Kiattisak Batsungnoen, Chalalai Hanchenlaksh, Mathuros Tipayamongkholgul, Susan Woskie
More than 11 million Thai people (38%) work in agriculture, but since most are in the informal sector, government enforcement and support are very limited. As a result, working conditions on Thai farms vary greatly, putting the health of many agricultural workers at risk. A cross-sectional study in three Thai provinces collected information on the work activities and conditions of 424 farmers representing five farm types: rice, vegetable, flower, rice/vegetable, and flower/vegetable. The agricultural workers were mainly women (60%); their average age was 53 but ranged from 18 to 87 years...
January 30, 2018: Annals of Work Exposures and Health
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