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https://www.readbyqxmd.com/read/29161696/the-protein-expression-level-of-a-heterogeneous-gene-inserted-in-lipi-1-of-the-listeria-ivanovii-genome-relies-on-its-insertion-orientation
#1
Sijing Liu, Mingjuan Jiang, Lin Su, Tian Tang, Xiang Zhang, Yongyu Li, Qikang Pu, Chenyan Ren, Chuan Wang
Due to its capability to multiply in either phagocytic or nonphagocytic cells, and to subsequently elicit a robust cellular immune response, Listeria ivanovii (LI) is thought to be feasible for developing bacteria-based live attenuated vaccines. We previously generated several recombinant LI strains expressing Mycobacterium tuberculosis antigens. Since the expression level of heterogeneous protein was sometimes very low, we attempted to elucidate the principle of heterogeneous protein expression in such recombinant LI strains...
November 22, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29160147/impact-of-complete-spinal-cord-injury-on-healing-of-skin-ulcers-in-mouse-models
#2
Suneel Kumar, Martin L Yarmush, Biraja C Dash, Henry C Hsia, Francois Berthiaume
Pressure ulcers (PUs) are common debilitating complications of traumatic spinal cord injury (SCI) and tend to occur in soft tissues around bony prominences. There is, however, little known about the impact of SCI on skin wound healing due to the lack of suitable animal models for studies in controlled experimental settings. Herein we describe a reproducible and clinically relevant mouse model of PUs in the context of complete SCI. Adult male mice (BALB/c) were subjected to thoracic (T9-T10) complete SCI. Immediately after, a skin fold on the back of the mice was lifted and sandwiched between two magnetic discs held in place for 12 hours, thus creating an ischemic area that developed into a PU over the following days...
November 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29159831/design-and-development-of-low-cost-polyurethane-biopolymer-based-on-castor-oil-and-glycerol-for-biomedical-applications
#3
A C W Tan, B J Polo-Cambronell, E Provaggi, C Ardila-Suárez, G E Ramirez-Caballero, V G Baldovino-Medrano, D M Kalaskar
In the current study, we present the synthesis of novel low cost bio-polyurethane compositions with variable mechanical properties based on castor oil and glycerol for biomedical applications. A detailed investigation of the physicochemical properties of the polymer was carried out by using mechanical testing, ATR-FTIR, and X-ray photoelectron spectroscopy (XPS). Polymers were also tested in short term in-vitro cell culture with human mesenchymal stem cells to evaluate their biocompatibility for potential applications as biomaterial...
November 21, 2017: Biopolymers
https://www.readbyqxmd.com/read/29159071/first-case-report-of-infection-caused-by-cupriavidus-gilardii-in-a-non-immunocompromised-chinese-patient
#4
Zhen Zhang, Wanyan Deng, Shuling Wang, Lanlan Xu, Ling Yan, Pu Liao
Cupriavidus gilardii was first identified as an aerobic, gram-negative, glucose-nonfermenting rod. C. gilardii has been characterized as an organism with low pathogenicity that causes opportunistic infections and few case reports of infection caused by this organism previously. We encountered the first case of bloodstream infection caused in China by C. gilardii in a 87-year old man without obvious immunodeficiency. The isolate were identified as C. gilardii by 16S rRNA sequencing. The infected patient was treated according to the laboratory's antibiogram of this strain...
2017: IDCases
https://www.readbyqxmd.com/read/29158809/alkaline-phosphatase-to-albumin-ratio-as-a-prognostic-indicator-in-pancreatic-ductal-adenocarcinoma-after-curative-resection
#5
Ning Pu, Shanshan Gao, Yadong Xu, Guochao Zhao, Yang Lv, Abulimiti Nuerxiati, Jian-Ang Li, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Xiaolin Wang, Wenhui Lou, Lingxiao Liu, Wenchuan Wu
Background: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor and the models for survival prediction in PDAC patients after curative resection are still limited. Preoperative alkaline phosphatase-to-albumin ratio (APAR), an original inflammation-based score, has been established to analyze the prognostic significance in PDAC. Therefore, in this study, we aim to formulate a valuable prognostic nomogram for PDAC following curative resection. Methods: A total of 354 patients with PDAC undergoing curative resection were retrospectively enrolled in this study...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29157092/single-agent-and-synergistic-combinatorial-efficacy-of-first-in-class-small-molecule-imipridone-onc201-in-hematological-malignancies
#6
Varun V Prabhu, Mala K Talekar, Amriti R Lulla, C Leah B Kline, Lanlan Zhou, Junior Hall, A Pieter J Van den Heuvel, David T Dicker, Jawad Babar, Stephan A Grupp, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, Nadia Khan, Wolfgang Oster, Joshua E Allen, Wafik S El-Deiry
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ONC201 demonstrated (GI50 1-8 µM) dose- and time-dependent efficacy in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), Burkitt's lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma (CTCL), Hodgkin's lymphoma (nodular sclerosis) and multiple myeloma (MM) cell lines including cells resistant to standard of care (dexamethasone in MM) and primary samples...
November 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29155449/baicalein-inhibits-acinar-to-ductal-metaplasia-of-pancreatic-acinal-cell-ar42j-via-improving-the-inflammatory-microenvironment
#7
Wei-Ling Pu, Ying-Ying Luo, Ru-Yu Bai, Ao-Wei Guo, Kun Zhou, Yun-Sha Zhang, Lin Miao, Curzio Rüegg, Micheal O Hottiger, Xiu-Mei Gao, Li-Kang Sun
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar-to-ductal metaplasia (ADM). Baicalein has been shown to exert anti-inflammatory and anti-tumor effects for CP or PDAC, respectively. The aim of our study was to investigate the effect of baicalein, and the putative underlying mechanism, on inflammatory cytokines-induced ADM of rat pancreatic acinar cell line AR42J...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29152794/highly-sustainable-zinc-anodes-for-the-rechargeable-hybrid-aqueous-battery
#8
Kyung Eun Kate Sun, Tuan Hoang, The Nam Long Doan, Yan Yu, Pu Chen
The synthesis of novel zinc electrodes has been successfully implemented by the electroplating method with the aid of inorganic additives in the electroplating solution. The selected inorganic additives are indium sulfate, tin oxide, and boric acid. From X-ray diffraction results, the synthesized zinc electrodes prefer (002) and/or (103) crystallographic orientations, representing basal morphology and high resistance to dendrite growth. The corrosion rates of these electroplated zinc samples decrease as much as 11 times smaller than the rate of a zinc foil when the zinc materials are in contact with the aqueous electrolyte of a rechargeable hybrid aqueous battery (ReHAB)...
November 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29152661/apolipoprotein-status-in-type-2-diabetes-mellitus-and-its-complications-review
#9
Puhong Zhang, Jialin Gao, Chun Pu, Yao Zhang
Dyslipidaemia in type 2 diabetes mellitus (T2DM) is characterized by high plasma triglyceride concentrations, reduced high‑density lipoprotein concentrations and increased small density low‑density lipoprotein concentrations. Dyslipidaemia may lead to cardiovascular disease (CVD) and other complications. Apolipoproteins mainly comprise six species, apolipoprotein (apo)A, apoB, apoC, apoD, apoE and apoM, which are important components of plasma lipoproteins that carry lipids and stabilize the structure of lipoproteins...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29151922/clinicopathological-characteristics-and-prognostic-value-of-signet-ring-cells-in-gastric-carcinoma-a-meta-analysis
#10
Run-Cong Nie, Shu-Qiang Yuan, Yuan-Fang Li, Yong-Ming Chen, Xiao-Jiang Chen, Bao-Yan Zhu, Li-Pu Xu, Zhi-Wei Zhou, Shi Chen, Ying-Bo Chen
Background and Objectives: Previous studies of the prognostic value of the signet ring cell (SRC) type have yielded inconsistent results. Therefore, the aim of the present meta-analysis is to explore the clinicopathological characteristics and prognostic value of SRCs. Methods: Relevant articles that compared SRC and non-SRC type in PubMed and Web of Science were comprehensively searched. Then, a meta-analysis was performed. Results: A total of 19 studies including 35947 cases were analyzed. Compared with non-SRC patients, SRC patients tended to be younger (WMD: -3...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151409/-curative-effect-of-paraquat-detoxification-recipe-combined-with-continuous-hemoperfusion-in-the-treatment-of-patients-with-app-and-clinical-value-of-presepsin
#11
Weizhan Wang, Jing Li, Baoyue Zhu, Xun Gao, Qingmian Xiao, Hongna Qi, Yanqiao Ye, Yongjian Liu, Yongyan Han, Gongying Ma, Pu Wang
OBJECTIVE: To investigate the clinical effect of paraquat (PQ) detoxification recipe combined with continuous hemoperfusion (HP) in the treatment of patients with acute paraquat poisoning (APP) and clinical significance of soluble CD14 subtype (sCD14-st, Presepsin). METHODS: A prospective randomized controlled trial was conducted. 152 patients with moderate APP admitted to Department of Emergency Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from July 2013 to June 2017 were enrolled, and they were randomly divided into three groups...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29148361/characterization-of-biofilm-formation-by-enterococcus-faecalis-isolates-derived-from-urinary-tract-infections-in-china
#12
Jin-Xin Zheng, Bing Bai, Zhi-Wei Lin, Zhang-Ya Pu, Wei-Ming Yao, Zhong Chen, Duo-Yun Li, Xiang-Bin Deng, Qi-Wen Deng, Zhi-Jian Yu
PURPOSE: This study explored the prevalence and characteristics of Enterococcus faecalis biofilm formation by urinary tract infection (UTI) isolates in order to identify virulence factors associated with biofilm formation. METHODOLOGY: A total of 113 E. faecalis isolates were collected from UTI patients in Shenzhen, China. The isolates were subjected to multilocus sequence typing based on housekeeping genes. Biofilms were detected by crystal violet staining and the expression levels of the E...
November 17, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29147903/role-of-dj-1-in-fertilization
#13
An Chunna, Xiao-Ping Pu
Neither a sperm nor an egg can develop into an individual alone. Only when the sperm and egg bind and fuse, which is known as fertilization, can they acquire the ability of developing into new individuals. DJ-1 was reported to be involved in the process of fertilization.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29147168/study-of-the-characteristics-of-pulmonary-trunk-in-pulmonary-hypertension-secondary-to-left-heart-disease-using-pressure-velocity-loops-pu-loops
#14
Shizuo Hanya, Kengo Yoshii, Motoaki Sugawara
Objectives: Although pulmonary hypertension (PH) caused by left heart disease (PH-LHD) is more common in PH, little is known about its properties of pulmonary artery (PA) in PH-LHD. The purpose of this study was to measure pulmonary regional pulse wave velocity (PWV) and to quantify the magnitude of reflected waves in patients with PH-LHD by the analysis of the pressure-velocity loops (PU-loop). Methods: High-fidelity PA pressure (Pm) and PA velocity (Vm) were measured in 11 subjects with PH-LHD (mean Pm>25 mmHg), 1 subject with atrial septal defect (ASD) without PH and 12 control subjects, using multisensor catheters...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29146487/mitochondria-a-master-regulator-in-macrophage-and-t-cell-immunity
#15
REVIEW
Pu-Ste Liu, Ping-Chih Ho
Orchestrating biological activities of immune cells through metabolic reprogramming reveals a new approach to harnessing immune responses. Increasing evidence reveals that the mitochondrion is a central regulator for modulating metabolic reprogramming and controlling immune cell activation and functions. In addition to supporting bioenergetic demands, the mitochondrion serves as a signaling platform through the generation of reactive oxygen species and metabolites of the tricarboxylic acid cycle to modulate signaling cascades controlling immune cell activation and immune responses...
November 13, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29143920/distinguishing-the-disease-associated-snps-based-on-composition-frequency-analysis
#16
Wenling Li, Menglong Li, Xuemei Pu, Yanzhi Guo
Single-nucleotide polymorphism (SNP) is a basical variation in genome. When SNPs occur at the binding sites of microRNA, they can influence the binding efficiency, cause a fluctuation of the mRNA in vivo, and thus arouse posttranscriptional level abnormality. Therefore, SNP has a strong correlation with diseases. Although enormous SNPs have been experimentally identified, only a tiny proportion of them are truly disease-associated SNPs (dSNPs) that relate to microRNA modification and then are involved in disease causing process...
November 16, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29143012/%C3%AE-alanine-and-n-terminal-cationic-substituents-affect-polyamide-dna-binding
#17
Beibei Liu, Shuo Wang, Karl Aston, Kevin J Koeller, Shahrzad Fanny Hakami Kermani, Carlos H Castañeda, M José Scuderi, Rensheng Luo, James K Bashkin, W David Wilson
Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understand the variations in kinetics and affinities caused by these modifications on PA-DNA interactions, a comprehensive set of PAs with different numbers and positions of β and different types of N-cationic groups was systematically designed and synthesized to bind their cognate sequence, the λB motif...
November 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29141362/-evaluation-of-the-psychological-feature-and-quality-of-life-in-outpatients-with-somatic-symptoms-disorder-in-a-general-hospital
#18
F H Cui, N N Xiong, X Hong, Y P Duan, J Wei
Objective: To explore the psychological features and quality of life in outpatients with somatic symptoms disorder in a general hospital. Methods: This cross-sectional study was conducted from 2014-05 to 2015-06. Patients diagnosed with major depressive disorder (MDD) and somatic symptoms disorder (SSD) were recruited from psychological outpatient department, and patients with peptic ulcer (PU) / reflux esophagitis (RE) were recruited from Gastroenterology. Depression scale of the patient health questionnaire (PHQ-9), Generalized Anxiety Disorder 7-item scale (GAD-7), Toronto Alexithymia scale (TAS), 12-item Short Form Health Survey (SF-12), items from Somatoform Disorder Screening Questionnaire were employed to evaluate the severity of depression, anxiety, alexithymia, quality of life, health care use and subjective feelings...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141258/the-omental-free-flap-a-review-of-usage-and-physiology
#19
Daniel Mazzaferro, Ping Song, Sameer Massand, Michael Mirmanesh, Rohit Jaiswal, Lee L Q Pu
No abstract text is available yet for this article.
November 15, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29140411/effect-of-angiotensin-ii-and-acth-on-adrenal-blood-flow-in-the-male-rat-adrenal-gland-in-vivo
#20
Abdul J Shah, Tamas Kriska, Kathryn M Gauthier, John R Falck, William B Campbell
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and/or zona glomeulosa cell-derived mediators. The role of these mediators in regulating adrenal blood flow (ABF) and mean arterial pressure (MAP) was examined in anesthetized rats. Ang II (0.01-100 ng/kg) increased ABF (maximal increase of 97.2 ± 6.9 perfusion units (PU) at 100 ng/kg) and MAP (basal, 115 ± 7 mm Hg; Ang II, 163 ± 5 mm Hg). ACTH (0.1-1000 ng/kg) also increased ABF (maximum increase of 91...
November 13, 2017: Endocrinology
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