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Pu Liu, Chao Zhang, Jin-Qi Ma, Li-Yuan Zhang, Bo Yang, Xin-Yu Tang, Ling Huang, Xin-Tong Zhou, Kun Lu, Jia-Na Li
Cytokinin oxidase/dehydrogenases (CKXs) play a critical role in the irreversible degradation of cytokinins, thereby regulating plant growth and development. Brassica napus is one of the most widely cultivated oilseed crops worldwide. With the completion of whole-genome sequencing of B. napus , genome-wide identification and expression analysis of the BnCKX gene family has become technically feasible. In this study, we identified 23 BnCKX genes and analyzed their phylogenetic relationships, gene structures, conserved motifs, protein subcellular localizations, and other properties...
March 16, 2018: Genes
Meixiang Zhang, Justine Ngo, Filomena Pirozzi, Ying-Pu Sun, Anthony Wynshaw-Boris
BACKGROUND: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate cellular models harboring specific disease-related genotypes. Of particular importance are ESC and iPSC applications capable of producing dorsal telencephalic neural progenitor cells (NPCs) that are representative of the cerebral cortex and overcome the challenges of maintaining a homogeneous population of cortical progenitors over several passages in vitro. While previous studies were able to derive NPCs from pluripotent cell types, the fraction of dorsal NPCs in this population is small and decreases over several passages...
March 15, 2018: Stem Cell Research & Therapy
Shou-Fei Gao, Ying-Ying Wang, Wei Ding, Pu Wang
UV guiding fibers are highly sought after in laser and spectroscopy applications. Recent advances in hollow-core fiber orient a practical approach for proper UV light delivery sustainable to high-power and long-term irradiation. In this Letter, we report two types of hollow-core negative-curvature fibers (NCFs) in a UV spectral range. Their structures consist of one ring of six small (7.9 μm in diameter) and four big (20.8 μm in diameter) tubes, enclosing a hollow core of similar size (∼15  μm in diameter)...
March 15, 2018: Optics Letters
Yubin Hou, Qian Zhang, Shuxian Qi, Xian Feng, Pu Wang
We demonstrate a polarization-maintaining (PM) dual-wavelength (DW) single-frequency Er-doped distributed Bragg reflection (DBR) fiber laser with 28 GHz stable frequency difference. A homemade PM low-reflectivity superimposed fiber Bragg grating (SFBG) is employed as the output port of the DBR fiber laser. The SFBG has two reflection wavelengths located in the same grating region. The reflectivity of both DWs is around 85%. The achieved linear polarization extinction ratio is more than 20 dB. The DWs of the laser output are located at 1552...
March 15, 2018: Optics Letters
Han Zhang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang
Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM...
March 14, 2018: Natural Products and Bioprospecting
Shu-Qiang Yuan, Run-Cong Nie, Yong-Ming Chen, Hai-Bo Qiu, Xiao-Ping Li, Xiao-Jiang Chen, Li-Pu Xu, Li-Fang Yang, Xiao-Wei Sun, Yuan-Fang Li, Zhi-Wei Zhou, Shi Chen, Ying-Bo Chen
The Glasgow Prognostic Score (GPS) has been shown to be associated with survival rates in patients with advanced cancer. The present study aimed to compare the GPS with the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in patients with gastric cancer with peritoneal seeding. For the investigation, a total of 384 gastric patients with peritoneal metastasis were retrospectively analyzed. Patients with elevated C-reactive protein (CRP; >10 mg/l) and hypoalbuminemia (<35 mg/l) were assigned a score of 2...
April 2018: Oncology Letters
Ahmed M Elkady, Dana Cobzas, Hongfu Sun, Gregg Blevins, Alan H Wilman
BACKGROUND: Combined R2* and quantitative susceptibility (QS) has been previously used in cross-sectional multiple sclerosis (MS) studies to distinguish deep gray matter (DGM) iron accumulation and demyelination. PURPOSE: We propose and apply discriminative analysis of regional evolution (DARE) to define specific changes in MS and healthy DGM. STUDY TYPE: Longitudinal (baseline and 2-year follow-up) retrospective study. SUBJECTS: Twenty-seven relapsing-remitting MS (RRMS), 17 progressive MS (PMS), and corresponding age-matched healthy subjects...
March 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
Mingming Pu, Lili Sheng, Sooyeon Song, Ting Gong, Thomas K Wood
Pseudomonas aeruginosa causes many biofilm infections, and the rugose small-colony variants (RSCVs) of this bacterium are important for infection. We found here that inactivation of PA2444, which we determined to be a serine hydroxymethyltransferase (SHMT), leads to the RSCV phenotype of P. aeruginosa PA14. In addition, loss of PA2444 increases biofilm formation by two orders of magnitude, increases exopolysaccharide by 45-fold, and abolishes swarming. The RSCV phenotype is related to higher cyclic diguanylate concentrations due to increased activity of the Wsp chemosensory system, including diguanylate cyclase WspR...
2018: Frontiers in Microbiology
Zhuo Wang, Ya-Hong Zhang, Chuang Guo, Hui-Ling Gao, Man-Li Zhong, Ting-Ting Huang, Na-Na Liu, Rui-Fang Guo, Tian Lan, Wei Zhang, Zhan-You Wang, Pu Zhao
Although the positive relationship between copper and Alzheimer's disease (AD) was reported by a lot of epidemiological data, the mechanism is not completely known. Copper is a redox metal and serves as a mediator of inflammation. Because the homeostasis of copper is altered in Aβ precursor protein (APP) and presenilin 1 (PS1) transgenic (Tg) mice, the using of copper chelators is a potential therapeutic strategy for AD. Here we report that a copper chelator, tetrathiomolybdate (TM), is a potential therapeutic drug of AD...
2018: Frontiers in Aging Neuroscience
Fei Xiao, Stanley Wang, Rina Barouch-Bentov, Gregory Neveu, Szuyuan Pu, Melanie Beer, Stanford Schor, Sathish Kumar, Vlad Nicolaescu, Brett D Lindenbach, Glenn Randall, Shirit Einav
Hepatitis C virus (HCV) spreads via secreted cell-free particles or direct cell-to-cell transmission. Yet, virus-host determinants governing differential intracellular trafficking of cell-free- and cell-to-cell-transmitted virus remain unknown. The host adaptor proteins (APs) AP-1A, AP-1B, and AP-4 traffic in post-Golgi compartments, and the latter two are implicated in basolateral sorting. We reported that AP-1A mediates HCV trafficking during release, whereas the endocytic adaptor AP-2 mediates entry and assembly...
March 13, 2018: MBio
Yi Jiang, Song Gao, Lihua Wu, Xiaohua Jin, Tao Deng, Ligang Wang, Shasha Huang, Xue Gao, Juan Chen, Dongyi Han, Huafang Gao, Pu Dai
To analyze the spectrum and founder effect of TMC1 mutations in patients with non-syndromic deafness in the Xiamen area. Sporadic pedigrees were detected by targeted next-generation sequencing, and 110 unrelated patients from Xiamen Special Education School were analyzed through Sanger sequencing for the TMC1 gene. In total, 53 SNPs were designed to analyze the haplotypes of the TMC1 c.2050G>C mutation. The probands of three families were found to be homozygous for TMC1 c.2050G>C, and their parents were all heterozygous for the TMC1 c...
April 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Federica Vezzali, Silvia Grassilli, Elisabetta Lambertini, Federica Brugnoli, Simone Patergnani, Ervin Nika, Roberta Piva, Paolo Pinton, Silvano Capitani, Valeria Bertagnolo
It has been recently demonstrated that high pre-treatment levels of miR-29b positively correlated with the response of patients with acute myeloid leukaemia (AML) to hypomethylating agents. Upmodulation of miR-29b by restoring its transcriptional machinery appears indeed a tool to improve therapeutic response in AML. In cells from acute promyelocytic leukaemia (APL), miR-29b is regulated by PU.1, in turn upmodulated by agonists currently used to treat APL. We explored here the ability of PU.1 to also regulate miR-29b in non-APL cells, in order to identify agonists that, upmodulating PU...
March 13, 2018: Journal of Cellular and Molecular Medicine
Shugo Sato, Satoru Ohisa, Yukihiro Hayashi, Ryo Sato, Daisuke Yokoyama, Tetsuya Kato, Michinori Suzuki, Takayuki Chiba, Yong-Jin Pu, Junji Kido
A lot of research, mostly using electron-injection layers (EILs) composed of alkali-metal compounds has been reported with a view to increase the efficiency of solution-processed organic light-emitting devices (OLEDs). However, these materials have intractable properties, such as a strong affinity for moisture, which cause the degradation of OLEDs. Consequently, optimal EIL materials should exhibit high electron-injection efficiency as well as be stable in air. In this study, polymer light-emitting devices (PLEDs) based on the commonly used yellow-fluorescence-emitting polymer F8BT, which utilize poly(diallyldimethylammonium)-based polymeric ionic liquids, are experimentally and analytically investigated...
March 13, 2018: Advanced Materials
Katarzyna Ropka-Molik, Anna Bereta, Kacper Żukowski, Mirosław Tyra, Katarzyna Piórkowska, Grzegorz Żak, Maria Oczkowicz
Objective: The aim of the present study was to identify genetic variants based on RNA-seq data, obtained via transcriptome sequencing of muscle tissue of pigs differing in muscle histological structure, and to verify the variants' effect on histological microstructure and production traits in a larger pig population. Methods: RNA-seq data was used to identify the panel of SNPs significantly related with percentage and diameter of each fiber type (I, IIA, IIB). Detected polymorphisms were mapped to QTLs regions...
March 13, 2018: Asian-Australasian Journal of Animal Sciences
Hanshuo Wu, Peng Wang, Jiaxin Song, Jun Ye, Jiangming Xu, Xiao Li, Pu Zhou
Random fiber laser, as a kind of novel fiber laser that utilizes random distributed feedback as well as Raman gain, has become a research focus owing to its advantages of wavelength flexibility, modeless property and output stability. Herein, a tunable optical parametric oscillator (OPO) enabled by a random fiber laser is reported for the first time. By exploiting a tunable random fiber laser to pump the OPO, the central wavelength of idler light can be continuously tuned from 3977.34 to 4059.65 nm with stable temporal average output power...
March 5, 2018: Optics Express
Yanqiang Guo, Chunsheng Peng, Yulin Ji, Pu Li, Yuanyuan Guo, Xiaomin Guo
The photon statistics and bunching of a semiconductor laser with external optical feedback are investigated experimentally and theoretically. In a chaotic regime, the photon number distribution is measured and undergoes a transition from Bose-Einstein distribution to Poisson distribution with increasing the mean photon number. The second order degree of coherence decreases gradually from 2 to 1. Based on Hanbury Brown-Twiss scheme, pronounced photon bunching is observed experimentally for various injection currents and feedback strengths, which indicates the randomness of the associated emission light...
March 5, 2018: Optics Express
Ling Cao, Shou-Fei Gao, Zhi-Gang Peng, Xiao-Cong Wang, Ying-Ying Wang, Pu Wang
We demonstrate a 2.8 μm gas Raman laser in a methane-filled hollow-core negative-curvature fiber with average power of 113 mW, pulse energy of 113 μJ and estimated peak power of 9.5 MW. Raman quantum efficiency of 40% has been reached from the pump source at 1.064 μm to the 2nd order vibrational Stokes at 2.812 μm using 1.8 MPa methane gas. To our knowledge, this is the first high peak power fiber-based gas Raman laser in mid-infrared region and a range of applications in supercontinuum generation, laser surgery, molecular tracing and gas detection are in prospect...
March 5, 2018: Optics Express
Steven L Percival
A novel hydrophilic polyurethane (PU) foam dressing which is impregnated with silver chloride, Optifoam® Gentle (OG) Ag+ (Medline Industries Inc., Chicago, Illinois), was evaluated in this study. The aims of this study were to determine the rate of elution of silver from the foam dressing over a period of 168 hours into simulated wound fluid and an evaluation of antimicrobial efficacy using zone of inhibition (ZOI), direct kill, and time-kill viability. Thirty-two microorganisms associated with wounds including Pseudomonas aeruginosa, Methicillin sensitive Staphylococcus aureus (MSSA), Acinetobacter baumannii, Candida albicans, and antibiotic-resistant strains (Methicillin-resistant S...
March 12, 2018: Surgical Technology International
Ding Chen, Jian Liu, Shuwei Duan, Pu Chen, Li Tang, Li Zhang, Zhe Feng, Guangyan Cai, Jie Wu, Xiangmei Chen
BACKGROUND/AIMS: In the past, little attention has been paid to patients with IgA nephropathy (IgAN) who had minimal proteinuria upon the onset. The aim of this study was to analyze the clinicopathological features and the prognostic factors in patients with IgA nephropathy. METHODS: Data of patients that had their first renal biopsy in our hospital and were diagnosed with primary IgAN with proteinuria <1 g/d from January 1995 to December 2014 were retrospectively examined...
March 6, 2018: Kidney & Blood Pressure Research
Xu Zhen, Chen Xie, Kanyi Pu
Nanoparticles for photothermal therapy: Real-time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature-related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPNCT ) that can not only convert photo-energy to heat but also emit temperature-correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPNCT detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature-dependent nature allows tumor temperature to be optically monitored under near-infrared (NIR) laser irradiation...
March 12, 2018: Angewandte Chemie
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