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https://www.readbyqxmd.com/read/28431374/atmospheric-fallout-radionuclides-in-peatland-from-southern-poland
#1
Tomasz Mróz, Edyta Łokas, Justyna Kocurek, Michał Gąsiorek
Two peat profiles were collected in a peat bog located in Southern Poland and their geochronology were determined using (210)Pb, (238,239+240)Pu and (137)Cs radiometric techniques. The (210)Pb chronologies were established using the constant rate of supply model (CRS) and are in good agreement with the Pu isotopes and (137)Cs time markers. Maximum activities of Pu isotopes were found at a depth corresponding to the early 1960s, which is the period characterized by the maximum nuclear weapon tests. The results showed that the (210)Pb method is the most accurate technique for the determination age and accumulation rate of a peat...
April 18, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28430957/cd25-expression-in-b-lymphoblastic-leukemia-lymphoma-predicts-t-9-22-q34-q11-philadelphia-chromosome-translocation-ph-and-is-associated-with-residual-disease-in-ph-negative-patients
#2
Pu Chen, Andrew Chu, Hamid Zia, Prasad Koduru, Robert Collins, Naomi Winick, Franklin Fuda, Weina Chen
Objectives: CD25 expression is associated with t(9;22)(q34;q11)/Philadelphia chromosome translocation (Ph); BCR-ABL1 rearrangement in B lymphoblastic leukemia/lymphoma (B-LL). However, the significance of CD25 expression in Ph negative (Ph-) B-LL regarding residual disease (RD) and genetic abnormalities is largely unknown. Methods: CD25 expression by flow cytometry (FC) was correlated with Ph status in 95 newly diagnosed B-LL patients and with RD status in day 29 marrow measured by FC in the context of cytogenetic risk stratification in Ph- patients...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28430626/expression-of-pd-l1-and-prognosis-in-breast-cancer-a-meta-analysis
#3
Minghui Zhang, Houbin Sun, Shu Zhao, Yan Wang, Haihong Pu, Yan Wang, Qingyuan Zhang
The associations between programmed cell death ligand 1 (PD-L1) and the prognosis of various cancers have always been a research topic of considerable interest. However, the prognostic value of PD-L1 in breast cancer patients remains a controversial subject. We aimed to assess the association between PD-L1 protein expression and clinicopathological features and the impact of this relationship on breast cancer survival. We performed a systematic search of the PubMed, EMBASE, and Cochrane Library databases to determine the correlations among PD-L1 expression, clinicopathological features and overall survival (OS)...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430224/spectral-shaping-for-suppressing-stimulated-raman-scattering-in-a-fiber-laser
#4
Haiyang Xu, Man Jiang, Chen Shi, Pu Zhou, Guomin Zhao, Xijia Gu
We report on the effects of spectral shaping of the output coupler fiber Bragg grating (OC-FBG) in a Yb-doped fiber laser on the laser emission spectrum for the purpose of inhabiting stimulated Raman scattering (SRS). The lasers with four different OC-FBGs were built and characterized. We found that the laser with a multiple reflection peak chirped-moiré OC-FBG produced a broad laser emission linewidth, which, in turn, led to about 100 times lower the SRS emission as compared with the laser with a 0.19 nm Gaussian-shaped OC-FBG...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28430018/characterization-of-canna-yellow-mottle-virus-in-a-new-host-alpinia-purpurata-in-hawaii
#5
Jingxin Zhang, Kishore K Dey, Birun Lin, Wayne B Borth, Michael J Melzer, Diane Sether, Yanan Wang, I-Chin Wang, Huifang Shen, Xiaoming Pu, Dayuan Sun, John S Hu
Canna yellow mottle virus (CaYMV) is an important badnavirus infecting Canna spp. worldwide. This is the first report of CaYMV in flowering ginger (Alpinia purpurata) in Hawaii, where it is associated with yellow mottling and necrosis of leaves, vein streaking, and stunted plants. We have sequenced CaYMV in A. purpurata (CaYMV-Ap) using a combination of next-generation sequencing and traditional Sanger sequencing techniques. The complete genome of CaYMV-Ap was 7,120 bp with an organization typical of other Badnavirus species...
April 21, 2017: Phytopathology
https://www.readbyqxmd.com/read/28429009/aggregation-of-cyclic-polypeptoids-bearing-zwitterionic-end-groups-with-attractive-dipole-dipole-and-solvophobic-interactions-a-study-by-small-angle-neutron-scattering-and-molecular-dynamics-simulation
#6
Pu Du, Ang Li, Xin Li, Yueheng Zhang, Changwoo Do, Lilin He, Steven W Rick, Vijay T John, Revati Kumar, Donghui Zhang
Aggregation behavior of cyclic polypeptoids bearing zwitterionic end-groups in methanol has been studied using a combination of experimental and simulation techniques. The data from SANS and cryo-TEM indicate that the solution contains small clusters of these cyclic polypeptoids, ranging from a single polypeptoid chain to small oligomers, while the linear counterpart shows no cluster formation. Atomistic molecular dynamics simulations reveal that the driving force for this clustering behavior is due to the interplay between the effective repulsion due to the solvation of the dipoles formed by the charged end-groups in each polypeptoid chain and the attractive forces due to dipole-dipole interactions and the solvophobic effect...
April 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28428791/genome-wide-association-study-for-pre-harvest-sprouting-resistance-in-a-large-germplasm-collection-of-chinese-wheat-landraces
#7
Yong Zhou, Hao Tang, Meng-Ping Cheng, Kwame O Dankwa, Zhong-Xu Chen, Zhan-Yi Li, Shang Gao, Ya-Xi Liu, Qian-Tao Jiang, Xiu-Jin Lan, Zhi-En Pu, Yu-Ming Wei, You-Liang Zheng, Lee T Hickey, Ji-Rui Wang
Pre-harvest sprouting (PHS) is mainly caused by the breaking of seed dormancy in high rainfall regions, which leads to huge economic losses in wheat. In this study, we evaluated 717 Chinese wheat landraces for PHS resistance and carried out genome-wide association studies (GWAS) using to 9,740 DArT-seq and 178,803 SNP markers. Landraces were grown across six environments in China and germination testing of harvest-ripe grain was used to calculate the germination rate (GR) for each accession at each site. GR was highly correlated across all environments...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28428754/pu-erh-tea-water-extract-mediates-cell-cycle-arrest-and-apoptosis-in-mda-mb-231-human-breast-cancer-cells
#8
Jing Xie, Haishuang Yu, Shuang Song, Chongye Fang, Xuanjun Wang, Zhongbin Bai, Xiao Ma, Shumei Hao, Hong-Ye Zhao, Jun Sheng
Pu-erh tea is believed to have health benefits, the growth inhibition activity of Pu-erh tea on breast cancer cell has not been investigated. In this study, we examined the activity of Pu-erh tea water extract on apoptosis and cell cycle arrest in the human breast adenocarcinoma cell line MDA-MB-231 and clarified its underlying mechanism of action. We found that Pu-erh tea extract inhibited cell proliferation and induced apoptosis in a dose-dependent manner. We also found that Pu-erh tea extract inhibited tumor cell growth within 24 h via accumulation of cells in S phase...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28427828/a-combined-clostridium-perfringens-trueperella-pyogenes-inactivated-vaccine-induces-complete-immunoprotection-in-a-mouse-model
#9
Wenlong Zhang, Pu Wang, Bing Wang, Bo Ma, Junwei Wang
Clostridium perfringens (C. perfringens) and Trueperella pyogenes (T. pyogenes) are two bacterial pathogens frequently associated with wound infections and following lethal complications in livestock. However, prudent use of antimicrobial agents is highly required given the emergence of multidrug-resistant strains of both bacteria and need for food safety. In the current study, a combined vaccine, composed of inactivated C. perfringens and T. pyogenes, was prepared. The amount of formaldehyde being used to inactivate two bacteria was optimized to retain the immunogenicity of antigens...
April 17, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28427058/dietary-selenium-or-zinc-supplementation-restores-brain-lipid-composition-and-membrane-fluidity-in-protein-undernourished-rats
#10
Olusegun L Adebayo, Bamidele A Salau, Rajat Sandhir, Gbenga A Adenuga
Studies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet...
April 21, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28425295/provider-and-patient-determinants-of-generic-levothyroxine-prescribing-an-electronic-health-records-based-study
#11
Robert J Romanelli, Vani Nimbal, Sarah K Dutcher, Xia Pu, Jodi B Segal
BACKGROUND: Despite the availability of generic levothyroxine products for more than a decade, uptake of these products is poor. OBJECTIVE: We sought to evaluate determinants of generic prescribing of levothyroxine. METHODS: In a cross-sectional analysis of electronic health records data between 2010 and 2013, we identified adult patients with a levothyroxine prescription from a primary-care physician (PCP) or endocrinologist. We used mixed-effect logistic regression models with random intercepts for prescribing provider to examine predictors of generic levothyroxine prescribing...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28424525/genome-wide-detection-of-copy-number-variation-in-chinese-indigenous-sheep-using-an-ovine-high-density-600%C3%A2-k-snp-array
#12
Qing Ma, Xuexue Liu, Jianfei Pan, Lina Ma, Yuehui Ma, Xiaohong He, Qianjun Zhao, Yabin Pu, Yingkang Li, Lin Jiang
Copy number variants (CNVs) represent a form of genomic structural variation underlying phenotypic diversity. In this study, we used the Illumina Ovine SNP 600 K BeadChip array for genome-wide detection of CNVs in 48 Chinese Tan sheep. A total of 1,296 CNV regions (CNVRs), ranging from 1.2 kb to 2.3 Mb in length, were detected, representing approximately 4.7% of the entire ovine genome (Oar_v3.1). We combined our findings with five existing CNVR reports to generate a composite genome-wide dataset of 4,321 CNVRs, which revealed 556 (43%) novel CNVRs...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423721/downregulation-of-phosphorylated-mkk4-is-associated-with-a-poor-prognosis-in-colorectal-cancer-patients
#13
Wang Pu-Ning, Huang Jun, Duan Ying-Hua, Zhou Jia-Min, Huang Pin-Zhu, Fan Xin-Juan, Huang Yan, Wang Lei, Liu Huan-Liang, Wang Jian-Ping, Huang Mei-Jin
Mitogen-activated protein kinase kinase 4 (MKK4) is a key mediator of Jun N-terminal kinase signaling and influences malignant metastasis. Here, we used immunohistochemistry to assess phosphorylated MMK4 (pMKK4) levels and examine their association with the clinicopathological features of a pilot set of patient samples consisting of normal colonic mucosa (NCM), colorectal adenoma (CA), and colorectal cancer (CRC) tissues. pMKK4 levels were also assessed in a validation set of CRC cases with accompanying follow-up data to confirm their clinicopathological and prognostic significance...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423602/promoter-hypermethylation-of-lgals4-correlates-with-poor-prognosis-in-patients-with-urothelial-carcinoma
#14
Meei-Maan Wu, Ching-Fei Li, Li-Fang Lin, Alexander Sheng-Shin Wang, Yeong-Shiau Pu, Hsiu-Hua Wang, Ai-Chung Mar, Chien-Jen Chen, Te-Chang Lee
Galectine-4 (gal-4), encoded by the LGALS4 gene, was recently shown to exhibit a tumor suppressive effect in colorectal carcinoma and pancreatic adenocarcinoma, although how the expression of this gene is regulated remains unknown. No reports describe the significance of gal-4 in the malignant potential of urothelial tumors. Thus, we analyzed LGALS4 methylation and gene expression and their clinical relevance and biological function in urothelial carcinoma (UC). LGALS4 methylation was initially identified as a progression biomarker for UC patients through genome-wide DNA methylation profiling of 16 tumor samples...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423307/aspects-of-phosphorus-physiology-associated-with-phosphate-induced-polar-lipid-remodelling-in-marine-microalgae
#15
José Pedro Cañavate, Isabel Armada, Ismael Hachero-Cruzado
Marine microalgae exhibit a diversified phosphorus physiology and have also been recently found to show high inter-taxa variability in their phosphate induced-polar lipids' remodelling. Identification of phosphorus physiology aspects that are more related to lipid remodelling can contribute to better understanding of such intricate phytoplankton lipid metabolism. Therefore, some aspects of phosphorus physiology related to its uptake, storage and use were evaluated in a taxonomically diversified group of nine marine microalgae that was arranged into three subgroups, each of them including species showing similar polar lipid responses to phosphate...
March 31, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28422285/hematopoietic-stem-progenitor-cell-differentiation-towards-myeloid-lineage-is-modulated-by-light-light-receptor-signaling
#16
Weikai Chen, Xin Lv, Changlong Liu, Ruoping Chen, Jianhe Liu, Haiyan Dai, Gang-Ming Zou
The cytokine LT-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells (LIGHT) is a member of the tumor necrosis factor (TNF) superfamily. It is expressed primarily on activated T lymphocytes, and detectable on monocytes, granulocytes, and immune dendritic cells. It mainly plays a role in immune regulation including T cell activation and dendritic cell maturation. We recently reported its role as an inducer in embryonic stem cell differentiation, but its role in regulation of adult stem cell has not been defined...
April 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28418381/sparse-panicle1-is-required-for-inflorescence-development-in-setaria-viridis-and-maize
#17
Pu Huang, Hui Jiang, Chuanmei Zhu, Kerrie Barry, Jerry Jenkins, Laura Sandor, Jeremy Schmutz, Mathew S Box, Elizabeth A Kellogg, Thomas P Brutnell
Setaria viridis is a rapid-life-cycle model panicoid grass. To identify genes that may contribute to inflorescence architecture and thus have the potential to influence grain yield in related crops such as maize, we conducted an N-nitroso-N-methylurea (NMU) mutagenesis of S. viridis and screened for visible inflorescence mutant phenotypes. Of the approximately 2,700 M2 families screened, we identified four recessive sparse panicle mutants (spp1-spp4) characterized by reduced and uneven branching of the inflorescence...
April 18, 2017: Nature Plants
https://www.readbyqxmd.com/read/28418038/5-methylcytosine-promotes-mrna-export-nsun2-as-the-methyltransferase-and-alyref-as-an-m-5-c-reader
#18
Xin Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jia-Wei Xu, Wei-Yi Lai, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang, Ying-Pu Sun, Yun-Gui Yang
5-methylcytosine (m(5)C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown. Here, we reveal that m(5)C modification is enriched in CG-rich regions and in regions immediately downstream of translation initiation sites and has conserved, tissue-specific and dynamic features across mammalian transcriptomes. Moreover, m(5)C formation in mRNAs is mainly catalyzed by the RNA methyltransferase NSUN2, and m(5)C is specifically recognized by the mRNA export adaptor ALYREF as shown by in vitro and in vivo studies...
April 18, 2017: Cell Research
https://www.readbyqxmd.com/read/28418036/maximal-violation-of-bell-inequalities-under-local-filtering
#19
Ming Li, Huihui Qin, Jing Wang, Shao-Ming Fei, Chang-Pu Sun
We investigate the behavior of the maximal violations of the CHSH inequality and Vèrtesi's inequality under the local filtering operations. An analytical method has been presented for general two-qubit systems to compute the maximal violation of the CHSH inequality and the lower bound of the maximal violation of Vértesi's inequality over the local filtering operations. We show by examples that there exist quantum states whose non-locality can be revealed after local filtering operation by the Vértesi's inequality instead of the CHSH inequality...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417567/a-versatile-and-simple-approach-to-generate-light-emission-in-semiconductors-mediated-by-electric-double-layers
#20
Jiang Pu, Taiyo Fujimoto, Yuki Ohasi, Shota Kimura, Chang-Hsiao Chen, Lain-Jong Li, Tomo Sakanoue, Taishi Takenobu
The light-emitting device is the primary device for current light sources. In principle, conventional light-emitting devices need heterostructures and/or intentional carrier doping to form a p-n junction. This junction formation is, however, very difficult to achieve for most emerging semiconductors, and the fabrication of light-emitting devices is invariably a significant challenge. This study proposes a versatile and simple approach to realize light-emitting devices. This proposed device requires only a semiconducting film with two electrodes that are covered with an electrolyte...
April 18, 2017: Advanced Materials
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