keyword
https://read.qxmd.com/read/38536992/ozone-therapy-improves-early-stages-of-osseointegration-in-ovariectomized-rats
#1
JOURNAL ARTICLE
William Phillip Pereira da Silva, João Matheus Fonseca E Santos, Mônica Caroline de Souza, Stéfany Barbosa, Anderson Maikon de Souza Santos, Edilson Ervolino, Ana Paula Farnezi Bassi, Cortino Sukotjo, Leonardo P Faverani
OBJECTIVE: the aim of this study was to analyze the influence of ozone therapy (OZN) on peri-implant bone repair in critical bones by installing osseointegrated implants in the tibia of ovariectomized rats. METHODOLOGY: ovariectomy was performed on 30 Wistar rats, aged six months (Rattus novergicus), and, after 90 days, osseointegrated implants were installed in each tibial metaphysis. The study groups were divided into the animals that received intraperitoneal ozone at a concentration of 700 mcg/kg - OZ Group (n=15) - and a control group that received an intraperitoneal saline solution and, for this reason, was named the SAL group (n=15)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536749/we-need-a-solid-scientific-basis-for-nature-based-climate-solutions-in-the-united-states
#2
JOURNAL ARTICLE
Kimberly A Novick, Trevor F Keenan, William R L Anderegg, Caroline P Normile, Benjamin R K Runkle, Emily E Oldfield, Gyami Shrestha, Dennis D Baldocchi, Margaret E K Evans, James T Randerson, Jonathan Sanderman, Margaret S Torn, Anna T Trugman, Christopher A Williams
No abstract text is available yet for this article.
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536724/in-silico-methods-for-immunogenicity-risk-assessment-and-human-homology-screening-for-therapeutic-antibodies
#3
JOURNAL ARTICLE
Aimee E Mattei, Andres H Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S Rosenberg, William D Martin, Anne S De Groot
In silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is 'fully human', T cell epitopes that are contained in the sequences of the biologic may activate the immune system, enabling the development of anti-drug antibodies that can reduce drug efficacy and may contribute to adverse events. Computational tools that identify T cell epitopes from primary amino acid sequences have been used to assess the immunogenic potential of therapeutic candidates for several decades...
2024: MAbs
https://read.qxmd.com/read/38535387/optimizing-the-release-pattern-of-telenomus-podisi-for-effective-biological-control-of-euschistus-heros-in-soybean
#4
JOURNAL ARTICLE
William Wyatt Hoback, Gabryele Ramos, Rafael Hayashida, Daniel Mariano Santos, Daniel de Lima Alvarez, Regiane Cristina de Oliveira
An augmentative biological control program using the egg parasitoid Telenomus podisi Ashmead (Hymenoptera: Platygastridae) is a promising tool for the management of the brown stink bug, Euschistus heros (Fabricius) (Hemiptera: Pentatomidae) in soybeans. The T. podisi are released as adults or pupae within lab-reared E. heros eggs. Because of the small size of the parasitoid and potentially limited dispersal ability, determining the optimal release pattern is critical for biological control of the target pest...
March 14, 2024: Insects
https://read.qxmd.com/read/38535110/left-ventricular-diastolic-dysfunction-is-associated-with-poor-functional-outcomes-after-endovascular-thrombectomy
#5
JOURNAL ARTICLE
Tony Y W Li, Emma M S Toh, Ying Ying Koh, Aloysius S T Leow, Bernard P L Chan, Hock-Luen Teoh, Raymond C S Seet, Anil Gopinathan, Cunli Yang, Vijay K Sharma, Leonard L L Yeo, Mark Y Chan, William K F Kong, Kian-Keong Poh, Benjamin Y Q Tan, Ching-Hui Sia
INTRODUCTION: With the advent of endovascular thrombectomy (ET), patients with acute ischaemic strokes (AIS) with large vessel occlusion (LVO) have seen vast improvements in treatment outcomes. Left ventricular diastolic dysfunction (LVDD) has been shown to herald poorer prognosis in conditions such as myocardial infarction. However, whether LVDD is related to functional recovery and outcomes in ischaemic stroke remains unclear. We studied LVDD for possible relation with clinical outcomes in patients with LVO AIS who underwent ET...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38532537/concentration-dependent-asymmetric-synergy-in-sds-ddao-mixed-surfactant-micelles
#6
JOURNAL ARTICLE
Luis M G Torquato, Gunjan Tyagi, William N Sharratt, Zain Ahmad, Najet Mahmoudi, Jérémie Gummel, Eric S J Robles, João T Cabral
We investigate the structure and interactions of a model anionic/amphoteric mixed surfactant micellar system, namely, sodium dodecyl sulfate (SDS) and N , N -dimethyldodecylamine N -oxide (DDAO), employing SANS, FTIR, DLS, and pH measurements, in the range 0.1-100 mM total surfactant concentration and 0-100% DDAO. Increasing surfactant concentration is found to elongate the prolate ellipsoid micelles ( R Polar ∼ 25-40 Å), accompanied by up to a 6-fold increase in micellar charge. The surfactant synergy, in terms of micellar charge and size, diffusion coefficient, solution pH, and headgroup interactions, was found to vary with concentration...
March 26, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38531639/community-testing-practices-for-autism-within-the-autism-and-developmental-disabilities-monitoring-network
#7
JOURNAL ARTICLE
Ashley Robinson Williams, Esther Amoakohene, Matthew J Maenner, Walter Zahorodny, Monica DiRienzo, Andrea Grzybowski, Jennifer Hall-Lande, Elise T Pas, Amanda V Bakian, Maya Lopez, Mary Patrick, Josephine Shenouda, Kelly A Shaw
BACKGROUND: No data exist at the population level on what tests are used to aid in the diagnosis of autism spectrum disorder in community practice. OBJECTIVES: To describe autism spectrum disorder testing practices to inform autism spectrum disorder identification efforts. METHODS: Data are from the Autism and Developmental Disabilities Monitoring Network, a multi-site surveillance system reporting prevalence estimates and characteristics of 8-year-old children with autism spectrum disorder...
March 26, 2024: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/38530923/epistasis-between-hla-drb1-16-02-01-and-slc16a11-t-c-g-t-t-reduces-odds-for-type-2-diabetes-in-southwest-american-indians
#8
JOURNAL ARTICLE
Robert C Williams, Robert L Hanson, Bjoern Peters, Kendall Kearns, William C Knowler, Clifton Bogardus, Leslie J Baier
We sought to identify genetic/immunologic contributors of type 2 diabetes in an indigenous American community by genotyping all study participants for both high resolution HLA-DRB1 alleles and SLC16A11 to test their risk and/or protection for T2D. These genes were selected based on independent reports that HLA-DRB1*16:02:01 is protective for T2D and that SLC16A11 associates with T2D in individuals with BMI<35kg/m2, and here test the interaction of the two loci with a more complete dataset and perform a BMI sensitivity test...
March 26, 2024: Diabetes
https://read.qxmd.com/read/38530774/extrarenal-symptoms-associate-with-worse-quality-of-life-in-patients-enrolled-in-the-amp-ra-sle-lupus-nephritis-network
#9
JOURNAL ARTICLE
Philip M Carlucci, Katherine Preisinger, Kristina K Deonaraine, Devyn Zaminski, Maria Dall'Era, Heather T Gold, Kenneth Kalunian, Andrea Fava, H Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L Barnas, Richard Furie, Betty Diamond, Anne Davidson, David Wofsy, Diane Kamen, Judith A James, Joel M Guthridge, William Apruzzese, Deepak Rao, Michael H Weisman, Peter M Izmirly, Jill Buyon, Michelle Petri
OBJECTIVE: Lupus nephritis (LN) can occur as an isolated component of disease activity or be accompanied by diverse extrarenal manifestations. Whether isolated renal disease is sufficient to decrease health related quality of life (HRQOL) remains unknown. This study compared Patient-Reported Outcomes Measurement Information System 29-Item (PROMIS-29) scores in LN patients with isolated renal disease to those with extrarenal symptoms to evaluate the burden of LN on HRQOL and inform future LN clinical trials incorporating HRQOL outcomes...
March 26, 2024: Rheumatology
https://read.qxmd.com/read/38530702/clinical-trial-inclusion-and-impact-on-early-adoption-of-medical-innovation-in%C3%A2-diverse-populations
#10
JOURNAL ARTICLE
Philip B Adamson, Melvin Echols, Ersilia M DeFilippis, Alanna A Morris, Mosi Bennett, William T Abraham, JoAnn Lindenfeld, John R Teerlink, Christopher M O'Connor, Allison T Connolly, Huanan Li, Mona Fiuzat, Muthiah Vaduganathan, Orly Vardeny, Wayne Batchelor, Kelly C McCants
BACKGROUND: Inadequate inclusion in clinical trial enrollment may contribute to health inequities by evaluating interventions in cohorts that do not fully represent target populations. OBJECTIVES: The aim of this study was to determine if characteristics of patients with heart failure (HF) enrolled in a pivotal trial are associated with who receives an intervention after approval. METHODS: Demographics from 2,017,107 Medicare patients hospitalized for HF were compared with those of the first 10,631 Medicare beneficiaries who received implantable pulmonary artery pressure sensors...
March 21, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530701/training-the-next-generation-of-data-monitoring-committee-members-an-initiative-of-the-heart%C3%A2-failure-collaboratory
#11
REVIEW
Thomas R Fleming, Janet Wittes, Mona Fiuzat, Michael R Bristow, Frank W Rockhold, Jason T Connor, Benjamin R Saville, Brian Claggett, Isabella Cavagna, William T Abraham, Thomas D Cook, JoAnn Lindenfeld, Christopher O'Connor, David L DeMets
Clinical trials are vital for assessing therapeutic interventions. The associated data monitoring committees (DMCs) safeguard patient interests and enhance trial integrity, thus promoting timely, reliable evaluations of those interventions. We face an urgent need to recruit and train new DMC members. The Heart Failure Collaboratory (HFC), a multidisciplinary public-private consortium of academics, trialists, patients, industry representatives, and government agencies, is working to improve the clinical trial ecosystem...
March 23, 2024: JACC. Heart Failure
https://read.qxmd.com/read/38530484/assessing-renal-tissue-temperature-changes-and-perfusion-effects-during-laser-activation-in-an-in-vivo-porcine-model
#12
JOURNAL ARTICLE
Ron Marom, Julie J Dau, Khurshid R Ghani, Timothy L Hall, William W Roberts
INTRODUCTION: High fluid temperatures have been seen in both in vitro and in vivo studies with laser lithotripsy, yet the thermal distribution within the renal parenchyma has not been well characterized. Additionally, the heat-sink effect of vascular perfusion remains uncertain. Our objectives were twofold: first, to measure renal tissue temperatures in response to laser activation in a calyx, and second, to assess the effect of vascular perfusion on renal tissue temperatures. METHODS: Ureteroscopy was performed in three porcine subjects with a prototype ureteroscope containing a temperature sensor at its tip...
March 26, 2024: World Journal of Urology
https://read.qxmd.com/read/38530357/pharmacological-suppression-of-the-otud4-cd73-proteolytic-axis-revives-antitumor-immunity-against-immune-suppressive-breast-cancers
#13
JOURNAL ARTICLE
Yueming Zhu, Anupam Banerjee, Ping Xie, Andrey A Ivanov, Amad Uddin, Qiao Jiao, Junlong J Chi, Lidan Zeng, Ji Young Lee, Yifan Xue, Xinghua Lu, Massimo Cristofanilli, William J Gradishar, Curtis J Henry, Theresa W Gillespie, Manali Ajay Bhave, Kevin Kalinsky, Haian Fu, Ivet Bahar, Bin Zhang, Yong Wan
Despite widespread utilization of immunotherapy, challenge to treat immune-cold tumors needs to be resolved. Multiomic analyses and experimental validation identified the OTUD4-CD73 proteolytic axis as a promising target in treating immune-suppressive triple negative breast cancer (TNBC). Mechanistically, deubiquitylation of CD73 by OTUD4 counteracted its ubiquitylation by TRIM21, resulting in CD73 stabilization that inhibits tumor immune responses. We further demonstrated the importance of TGF-β signaling for orchestrating the OTUD4-CD73 proteolytic axis within tumor cells...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38529895/tuning-surface-defect-states-in-sputtered-titanium-oxide-electron-transport-layers-for-enhanced-stability-of-organic-photovoltaics
#14
JOURNAL ARTICLE
Mehrad Ahmadpour, Mariam Ahmad, Michela Prete, John Lundsgaard Hansen, Denys I Miakota, William Greenbank, Yunlin Jacques Zheng, Michiel Top, Thomas Ebel, Horst-Günter Rubahn, Vida Turkovic, Stela Canulescu, Nadine Witkowski, Morten Madsen
Nonfullerene acceptors (NFAs) have dramatically improved the power conversion efficiency (PCE) of organic photovoltaics (OPV) in recent years; however, their device stability currently remains a bottleneck for further technological progress. Photocatalytic decomposition of nonfullerene acceptor molecules at metal oxide electron transport layer (ETL) interfaces has in several recent reports been demonstrated as one of the main degradation mechanisms for these high-performing OPV devices. While some routes for mitigating such degradation effects have been proposed, e...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38528600/correction-unravelling-cell-type-specific-responses-to-parkinson-s-disease-at-single-cell-resolution
#15
Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R Thal, Andrew Kottick, Victor J Hanson-Smith, Sebastian Guelfi, William Plumbly, T Grant Belgard, Emmanouil Metzakopian, Matthew G Holt
No abstract text is available yet for this article.
March 25, 2024: Molecular Neurodegeneration
https://read.qxmd.com/read/38528323/profiles-of-latinx-cultural-orientation-among-adolescents-associations-with-internalizing-symptoms-and-moderation-by-ethnic-racial-discrimination
#16
JOURNAL ARTICLE
Miriam Ortiz, Fantasy T Lozada, Oswaldo Moreno, Chelsea D Williams, Brendesha M Tynes
INTRODUCTION: The objectives of the current study were the following: (1) to explore multidimensional profiles of Latinx cultural orientation using Spanish language use, familismo, and ethnic-racial identity (ERI) affirmation among Latinx adolescents, (2) to test how Latinx cultural orientation profiles were associated with adolescents' internalizing symptoms (i.e., depressive symptoms and anxiety symptoms), and (3) to test whether associations between profiles and internalizing symptoms were moderated by adolescents' ethnic-racial discrimination experiences...
March 25, 2024: Journal of Adolescence
https://read.qxmd.com/read/38528004/ska2-regulated-hyperactive-secretory-autophagy-drives-neuroinflammation-induced-neurodegeneration
#17
JOURNAL ARTICLE
Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T Trussell, Katelyn X Li, Max L Pöhlmann, Sarah Mackert, Thomas M Geiger, Daniel E Heinz, Roy Lardenoije, Nina Dedic, Kenneth M McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C Robinson, Valentin Stein, Eicke Latz, William A Carlezon, Felix Hausch, Mathias V Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J Ressler, Nils C Gassen
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality of autophagy for secretion of vesicular cargo, regulates neuroinflammation-mediated neurodegeneration via SKA2 and FKBP5 signaling. SKA2 inhibits SA-dependent IL-1β release by counteracting FKBP5 function. Hippocampal Ska2 knockdown in male mice hyperactivates SA resulting in neuroinflammation, subsequent neurodegeneration and complete hippocampal atrophy within six weeks...
March 25, 2024: Nature Communications
https://read.qxmd.com/read/38527854/connecting-dementia-risk-loci-to-the-csf-proteome-identifies-pathophysiological-leads-for-dementia
#18
JOURNAL ARTICLE
Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Milan
Genome-wide association studies have successfully identified many genetic risk loci for dementia, but exact biological mechanisms through which genetic risk factors contribute to dementia remains unclear. Integrating CSF proteomic data with dementia risk loci could reveal intermediate molecular pathways connecting genetic variance to the development of dementia. We tested to what extent effects of known dementia risk loci can be observed in CSF levels of 665 proteins (proximity extension-based (PEA) immunoassays) in a deeply-phenotyped mixed-memory clinic cohort (n=502, mean age (sd) = 64...
March 25, 2024: Brain
https://read.qxmd.com/read/38527795/deep-learning-on-pre-procedural-computed-tomography-and-clinical-data-predicts-outcome-following-stroke-thrombectomy
#19
JOURNAL ARTICLE
James P Diprose, William K Diprose, Tuan-Yow Chien, Michael T M Wang, Andrew McFetridge, Gregory P Tarr, Kaustubha Ghate, James Beharry, JaeBeom Hong, Teddy Wu, Doug Campbell, P Alan Barber
BACKGROUND: Deep learning using clinical and imaging data may improve pre-treatment prognostication in ischemic stroke patients undergoing endovascular thrombectomy (EVT). METHODS: Deep learning models were trained and tested on baseline clinical and imaging (CT head and CT angiography) data to predict 3-month functional outcomes in stroke patients who underwent EVT. Classical machine learning models (logistic regression and random forest classifiers) were constructed to compare their performance with the deep learning models...
March 25, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38527786/a-mass-in-the-pineal-region-of-a-young-woman
#20
Lorraina J Robinson, Eric Goold, David Anderson, Robert C Rennert, William T Couldwell, Changhong Xing
No abstract text is available yet for this article.
March 25, 2024: Brain Pathology
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