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https://www.readbyqxmd.com/read/27913194/genetic-screening-of-thap1-in-primary-dystonia-patients-of-india
#1
Subhajit Giri, Tufan Naiya, Zaffar Equbal, Charulata Savant Sankhla, Shyamal Kumar Das, Kunal Ray, Jharna Ray
BACKGROUND: Primary Dystonia is a common movement disorder manifested by dystonic symptoms only. DYT6, a major genetic factor, plays a significant role in primary pure dystonia pathogenesis. In this study we analyzed THAP1 (DYT 6) gene in primary pure dystonia patients, which has been widely studied in other populations but not in Indians. METHODS: The study cohort contained 227 index primary pure dystonia patients with the involvement of cervical region and 254 neurologically control individuals collected from East Indian population...
November 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27906090/muscle-specific-deletion-of-socs3-increases-the-early-inflammatory-response-but-does-not-affect-regeneration-after-myotoxic-injury
#2
Kristy Swiderski, Savant S Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I Stapleton, René Koopman, Gordon S Lynch
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade is a key mediator of inflammatory cytokine action, and signaling via this pathway is increased in muscles with aging. As a negative regulator of JAK/STAT signaling, a key mediator of myogenic proliferation and differentiation, altered expression of suppressor of cytokine signaling (SOCS3) is likely to have important consequences for muscle regeneration...
October 24, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27891033/transthoracic-approach-for-lesions-involving-the-anterior-dorsal-spine-a-multidisciplinary-approach-with-good-outcomes
#3
Srikant Balasubramaniam, Devendra K Tyagi, Sheikh H Zafar, Hemant V Savant
INTRODUCTION: Anterior approach provides excellent visualization and access to the anterior thoracic spine. It may be used alone, in combination with a posterior midline approach or in a staged or sequential fashion. AIMS: To analyse our institutional experience in transthoracic approaches and to determine the safety and benefit of this approach in our patient series. MATERIALS AND METHODS: A total of 16 patients were operated for varying lesions of body of dorsal vertebra by the transthoracic approach...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27875485/a-comparative-study-of-the-water-drinking-test-in-eyes-with-open-angle-glaucoma-and-prior-trabeculectomy-or-tube-shunt
#4
Patricia Martinez, Valerie Trubnik, Benjamin E Leiby, Sarah E Hegarty, Reza Razeghinejad, Shravan Savant, Jonathan S Myers
PURPOSE: To compare the intraocular pressure (IOP) response after the water drinking test (WDT) in patients who have undergone trabeculectomy or tube shunt surgery. METHODS: This prospective study examined 40 eyes of 34 open-angle glaucoma subjects who had undergone trabeculectomy (n=20) or tube shunt surgery (n=20). Both groups were matched by IOP range and by number of topical antiglaucoma medications used. After a baseline IOP assessment, subjects drank 10 mL water per kg body weight over 15 minutes...
November 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27800152/muscle-specific-deletion-of-socs3-increases-the-early-inflammatory-response-but-does-not-affect-regeneration-after-myotoxic-injury
#5
Kristy Swiderski, Savant S Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I Stapleton, René Koopman, Gordon S Lynch
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade is a key mediator of inflammatory cytokine action, and signaling via this pathway is increased in muscles with aging. As a negative regulator of JAK/STAT signaling, a key mediator of myogenic proliferation and differentiation, altered expression of suppressor of cytokine signaling (SOCS3) is likely to have important consequences for muscle regeneration...
2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27775224/urine-cytology-of-nonurothelial-malignancies-a-10-year-experience-in-a-large-multihospital-healthcare-system
#6
Deepika Savant, Jaya Bajaj, Cecilia Gimenez, Oana C Rafael, Neda Mirzamani, Karen Chau, Melissa Klein, Kasturi Das
BACKGROUND: Urine cytology is the most frequently utilized test to detect urothelial cancer. Secondary bladder neoplasms need to be recognized as this impacts patient management. We report our experience on nonurothelial malignancies (NUM) detected in urine cytology over a 10-year period. METHODS: A 10-year retrospective search for patients with biopsy-proven NUM to the urothelial tract yielded 25 urine samples from 14 patients. Two cytopathologists blinded to the original cytology diagnosis reviewed the cytology and histology slides...
October 24, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27730056/pyogenic-granuloma-like-basal-cell-carcinoma-on-the-abdomen-a-deceptive-presentation
#7
Piyush Kumar, Anupam Das, Avijit Mondal, Sushil S Savant
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27687620/assessment-of-dietary-intake-of-children-with-chronic-kidney-disease
#8
Wun Fung Hui, Aisha Betoko, Jonathan D Savant, Alison G Abraham, Larry A Greenbaum, Bradley Warady, Marva M Moxey-Mims, Susan L Furth
OBJECTIVE: Our aim was to characterize the nutrient intake of children with chronic kidney disease (CKD) relative to recommended intake levels. METHODS: We conducted a cross-sectional study of dietary intake assessed by Food Frequency Questionnaire (FFQ) in The North American Chronic Kidney Disease in Children (CKiD) prospective cohort study. Nutrient intake was analyzed to estimate the daily consumption levels of various nutrients and compared with national guidelines for intake...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27617523/milia-like-idiopathic-calcinosis-cutis-in-a-child-with-down-syndrome
#9
Piyush Kumar, Sushil S Savant, Esther Nimisha, Anupam Das, Panchami Debbarman
Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Herein, we report a 5-year-old girl with multiple asymptomatic discrete milia-like firm papules distributed over the face and extremities. A diagnosis of milia-like idiopathic calcinosis cutis associated with Down Syndrome was provisionally made and was confirmed by histopathology and karyotyping...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27506502/paronychia-and-onychomadesis-due-to-pemphigus-vulgaris
#10
Sushil S Savant, Anupam Das, Piyush Kumar
No abstract text is available yet for this article.
August 4, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27506357/bioanalysis-of-dried-saliva-spot-dss-samples-using-detergent-assisted-sample-extraction-with-uhplc-ms-ms-detection
#11
Naiyu Zheng, Jianing Zeng, Qin C Ji, Aida Angeles, Anne-Francoise Aubry, Shenita Basdeo, Adela Buzescu, Ishani Savant Landry, Navin Jariwala, Wesley Turley, Richard Burrell, Mark E Arnold
Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home. A UHPLC-MS/MS assay was developed using detergent-assisted sample extraction to quantify BMS-927711, a drug candidate in development for the treatment of migraines, in human DSS. By implementing DSS sampling at the patients' home, the bioanalytical sample collection for pharmacokinetic evaluation can be done at the time of the acute migraine attack without the need for clinical visits...
August 31, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27459312/intraductal-tubulopapillary-neoplasm-of-the-pancreas-masquerading-as-pancreatic-neuroendocrine-carcinoma-review-of-the-literature-with-a-case-report
#12
Deepika Savant, Lili Lee, Kasturi Das
BACKGROUND: Intraductal tubulopapillary neoplasm of the pancreas (ITPN) is a rare tumor which was first described in 2009. We report a case with cytologic and histologic findings and discuss the pitfalls in diagnosing this entity on cytology. CASE: An 82-year-old female presented with a pancreatic body mass measuring 3.3 cm. Endoscopic ultrasound-guided fine-needle aspiration showed cells in cohesive clusters with high-grade nuclear atypia. Immunohistochemistry (IHC) showed the neoplastic cells to be positive for CK19, CD56 and chromogranin (focal)...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27456015/microrna-expression-in-a-readily-accessible-common-hepatic-artery-lymph-node-predicts-time-to-pancreatic-cancer-recurrence-postresection
#13
Hai V Nguyen, Jesse Gore, Xin Zhong, Sudha S Savant, Samantha Deitz-McElyea, C Max Schmidt, Michael G House, Murray Korc
Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27429936/transbuccal-versus-transoral-approach-for-management-of-mandibular-angle-fractures-a-prospective-clinical-and-radiographic-study
#14
Purva Vijay Sinai Khandeparker, Vikas Dhupar, Rakshit Vijay Sinai Khandeparker, Hunny Jain, Kiran Savant, Vikas Berwal
OBJECTIVES: We compared the transbuccal and transoral approaches in the management of mandibular angle fractures. MATERIALS AND METHODS: Sixty patients with mandibular angle fractures were randomly divided into two equal groups (A, transoral approach; group B, transbuccal approach) who received fracture reduction using a single 2.5 mm 4 holed miniplate with a bar using either of the two approaches. Intraoperatively, the surgical time and the ease of surgical assess for fixation were noted...
June 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27356339/the-abyssal-society-fran%C3%A3-ois-alphonse-forel-and-the-case-of-deep-fauna-in-late-19th-century
#15
Sara Campanella
Ichthyological investigations and technological advancements, such as the laying of submarine telegraph cables, promoted new dredging methods in the second half of the 19th century. In contrast to the idea of a lifeless deep ocean (Edward Forbes' azoic hypothesis), the discovery of deep water fauna and the challenge of defining its systematics opened up new theoretical perspectives. In this frame, which was already marked by the impact of Darwin's theory, naturalistic surveys in freshwater environments in western Switzerland intertwined with those of oceanographic expeditions...
2016: Nuncius
https://www.readbyqxmd.com/read/27346080/the-bayesian-savant
#16
Karl Friston
No abstract text is available yet for this article.
July 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27293267/worn-down-nails-affecting-toe-nails
#17
Piyush Kumar, Sushil S Savant, Shahid Hassan, Anupam Das, Panchami Deb Barman
No abstract text is available yet for this article.
May 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27285466/the-effects-of-apremilast-on-the-qtc-interval-in-healthy-male-volunteers-a-formal-thorough-qt-study
#18
Maria Palmisano, Anfan Wu, Mahmoud Assaf, Liangang Liu, C Hyung Park, Ishani Savant, Yong Liu, Simon Zhou
OBJECTIVE: This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an electrocardiogram (ECG). MATERIALS AND METHODS: Healthy male subjects received each of 4 treatments in a randomized, crossover manner. In the 2 active treatment periods, apremilast 30 mg (therapeutic exposure) or 50 mg (supratherapeutic exposure) was administered twice daily for 9 doses. A placebo control was used to ensure doubleblind treatment of apremilast, and an openlabel, single dose of moxifloxacin 400 mg was administered as a positive control...
August 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27241812/angiopoietin-2-mediates-thrombin-induced-monocyte-adhesion-and-endothelial-permeability
#19
K Rathnakumar, S Savant, H Giri, A Ghosh, B Fisslthaler, I Fleming, U Ram, A K Bera, H G Augustin, M Dixit
UNLABELLED: Essentials Mechanism of thrombin-induced inflammation is not fully understood. Thrombin induced monocyte adhesion and barrier loss require Angiopoietin-2 (Ang-2). Ang-2 mediates vessel leakage and monocyte adhesion through SHP-2/p38MAPK pathway. Calcium dependent SHP2/p38MAPK activation regulates Ang-2 expression through a feedback loop. SUMMARY: Background Thrombin imparts an inflammatory phenotype to the endothelium by promoting increased monocyte adhesion and vascular permeability...
August 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27216198/early-epigenetic-downregulation-of-microrna-192-expression-promotes-pancreatic-cancer-progression
#20
Sandeep K Botla, Soniya Savant, Pouria Jandaghi, Andrea S Bauer, Oliver Mücke, Evgeny A Moskalev, John P Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Matthias M Gaida, Markus W Büchler, Oliver Strobel, Thilo Hackert, Nathalia A Giese, Hellmut G Augustin, Jörg D Hoheisel
Pancreatic ductal adenocarcinoma (PDAC) is characterized by very early metastasis, suggesting the hypothesis that metastasis-associated changes may occur prior to actual tumor formation. In this study, we identified miR-192 as an epigenetically regulated suppressor gene with predictive value in this disease. miR-192 was downregulated by promoter methylation in both PDAC and chronic pancreatitis, the latter of which is a major risk factor for the development of PDAC. Functional studies in vitro and in vivo in mouse models of PDAC showed that overexpression of miR-192 was sufficient to reduce cell proliferation and invasion...
July 15, 2016: Cancer Research
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