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Piyush Kumar, Anupam Das, Avijit Mondal, Sushil S Savant
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
Wun Fung Hui, Aisha Betoko, Jonathan D Savant, Alison G Abraham, Larry A Greenbaum, Bradley Warady, Marva M Moxey-Mims, Susan L Furth
OBJECTIVE: Our aim was to characterize the nutrient intake of children with chronic kidney disease (CKD) relative to recommended intake levels. METHODS: We conducted a cross-sectional study of dietary intake assessed by Food Frequency Questionnaire (FFQ) in The North American Chronic Kidney Disease in Children (CKiD) prospective cohort study. Nutrient intake was analyzed to estimate the daily consumption levels of various nutrients and compared with national guidelines for intake...
September 29, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Piyush Kumar, Sushil S Savant, Esther Nimisha, Anupam Das, Panchami Debbarman
Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Herein, we report a 5-year-old girl with multiple asymptomatic discrete milia-like firm papules distributed over the face and extremities. A diagnosis of milia-like idiopathic calcinosis cutis associated with Down Syndrome was provisionally made and was confirmed by histopathology and karyotyping...
2016: Dermatology Online Journal
Sushil S Savant, Anupam Das, Piyush Kumar
No abstract text is available yet for this article.
August 4, 2016: Indian Journal of Dermatology, Venereology and Leprology
Naiyu Zheng, Jianing Zeng, Qin C Ji, Aida Angeles, Anne-Francoise Aubry, Shenita Basdeo, Adela Buzescu, Ishani Savant Landry, Navin Jariwala, Wesley Turley, Richard Burrell, Mark E Arnold
Dried saliva spot (DSS) sampling is a non-invasive sample collection technique for bioanalysis that can be potentially implemented at the patient's home. A UHPLC-MS/MS assay was developed using detergent-assisted sample extraction to quantify BMS-927711, a drug candidate in development for the treatment of migraines, in human DSS. By implementing DSS sampling at the patients' home, the bioanalytical sample collection for pharmacokinetic evaluation can be done at the time of the acute migraine attack without the need for clinical visits...
August 31, 2016: Analytica Chimica Acta
Deepika Savant, Lili Lee, Kasturi Das
BACKGROUND: Intraductal tubulopapillary neoplasm of the pancreas (ITPN) is a rare tumor which was first described in 2009. We report a case with cytologic and histologic findings and discuss the pitfalls in diagnosing this entity on cytology. CASE: An 82-year-old female presented with a pancreatic body mass measuring 3.3 cm. Endoscopic ultrasound-guided fine-needle aspiration showed cells in cohesive clusters with high-grade nuclear atypia. Immunohistochemistry (IHC) showed the neoplastic cells to be positive for CK19, CD56 and chromogranin (focal)...
2016: Acta Cytologica
Hai V Nguyen, Jesse Gore, Xin Zhong, Sudha S Savant, Samantha Deitz-McElyea, C Max Schmidt, Michael G House, Murray Korc
Lymph node involvement in pancreatic adenocarcinoma (PAC) predicts postresection survival, but early lymph node metastasis detection is not easily accomplished. We assessed a panel of microRNAs (miRNAs) in a common hepatic artery lymph node (station 8) that is readily accessible during pancreatoduodenectomy (PD) to determine if increased miRNA levels correlate with postresection recurrence. Station 8 lymph nodes overlying the common hepatic artery collected during PD were assayed for miRNA-10b, miRNA-30c, miRNA-21, and miRNA-155 and cytokeratin-19 (CK19), an epithelial cell marker, using quantitative PCR...
October 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Purva Vijay Sinai Khandeparker, Vikas Dhupar, Rakshit Vijay Sinai Khandeparker, Hunny Jain, Kiran Savant, Vikas Berwal
OBJECTIVES: We compared the transbuccal and transoral approaches in the management of mandibular angle fractures. MATERIALS AND METHODS: Sixty patients with mandibular angle fractures were randomly divided into two equal groups (A, transoral approach; group B, transbuccal approach) who received fracture reduction using a single 2.5 mm 4 holed miniplate with a bar using either of the two approaches. Intraoperatively, the surgical time and the ease of surgical assess for fixation were noted...
June 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Sara Campanella
Ichthyological investigations and technological advancements, such as the laying of submarine telegraph cables, promoted new dredging methods in the second half of the 19th century. In contrast to the idea of a lifeless deep ocean (Edward Forbes' azoic hypothesis), the discovery of deep water fauna and the challenge of defining its systematics opened up new theoretical perspectives. In this frame, which was already marked by the impact of Darwin's theory, naturalistic surveys in freshwater environments in western Switzerland intertwined with those of oceanographic expeditions...
2016: Nuncius
Karl Friston
No abstract text is available yet for this article.
July 15, 2016: Biological Psychiatry
Piyush Kumar, Sushil S Savant, Shahid Hassan, Anupam Das, Panchami Deb Barman
No abstract text is available yet for this article.
May 2016: Indian Journal of Dermatology
Maria Palmisano, Anfan Wu, Mahmoud Assaf, Liangang Liu, C Hyung Park, Ishani Savant, Yong Liu, Simon Zhou
OBJECTIVE: This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an electrocardiogram (ECG). MATERIALS AND METHODS: Healthy male subjects received each of 4 treatments in a randomized, crossover manner. In the 2 active treatment periods, apremilast 30 mg (therapeutic exposure) or 50 mg (supratherapeutic exposure) was administered twice daily for 9 doses. A placebo control was used to ensure doubleblind treatment of apremilast, and an openlabel, single dose of moxifloxacin 400 mg was administered as a positive control...
August 2016: International Journal of Clinical Pharmacology and Therapeutics
K Rathnakumar, S Savant, H Giri, A Ghosh, B Fisslthaler, I Fleming, U Ram, A K Bera, H G Augustin, M Dixit
UNLABELLED: Essentials Mechanism of thrombin-induced inflammation is not fully understood. Thrombin induced monocyte adhesion and barrier loss require Angiopoietin-2 (Ang-2). Ang-2 mediates vessel leakage and monocyte adhesion through SHP-2/p38MAPK pathway. Calcium dependent SHP2/p38MAPK activation regulates Ang-2 expression through a feedback loop. SUMMARY: Background Thrombin imparts an inflammatory phenotype to the endothelium by promoting increased monocyte adhesion and vascular permeability...
August 2016: Journal of Thrombosis and Haemostasis: JTH
Sandeep K Botla, Soniya Savant, Pouria Jandaghi, Andrea S Bauer, Oliver Mücke, Evgeny A Moskalev, John P Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Matthias M Gaida, Markus W Büchler, Oliver Strobel, Thilo Hackert, Nathalia A Giese, Hellmut G Augustin, Jörg D Hoheisel
Pancreatic ductal adenocarcinoma (PDAC) is characterized by very early metastasis, suggesting the hypothesis that metastasis-associated changes may occur prior to actual tumor formation. In this study, we identified miR-192 as an epigenetically regulated suppressor gene with predictive value in this disease. miR-192 was downregulated by promoter methylation in both PDAC and chronic pancreatitis, the latter of which is a major risk factor for the development of PDAC. Functional studies in vitro and in vivo in mouse models of PDAC showed that overexpression of miR-192 was sufficient to reduce cell proliferation and invasion...
July 15, 2016: Cancer Research
Rumana Hussain, Vijay Savant
PURPOSE: To describe our experience of the use of subconjunctival bevacizumab in conjunction with fine-needle diathermy for the treatment of corneal vascularization. METHODS: Retrospective analysis of cases treated between 2010 and 2013. RESULTS: Those patients with corneal lipid deposition had good results following treatment with 3/5 cases requiring more than one session of treatment. A single patient with severe atopy and multiple previous failed penetrating keratoplasty underwent five sessions of treatment but his third graft subsequently also failed...
May 18, 2016: Seminars in Ophthalmology
Mio Hamatani, Naoto Jingami, Kengo Uemura, Naoe Nakasone, Hisanori Kinoshita, Hodaka Yamakado, Haruaki Ninomiya, Ryosuke Takahashi
A 40-year-old man was referred to our hospital because of vertical supranuclear gaze palsy, frequent sudden loss of muscle tonus and ataxia for several years. He had a history of prolonged neonatal jaundice. He was given a diagnosis of autism in his childhood, followed by a diagnosis of schizophrenia in his teenage. He also developed a savant skill of calendar calculating. (123)I-IMP-SPECT showed decreased cerebral blood flow in the left frontotemporal lobe as often seen in savant syndrome. Although genetic analysis of NPC1 and NPC2 revealed no pathogenic mutation, filipin staining of cultured fibroblasts from his biopsied skin revealed a certain amount of intracellular cholesterol storage pattern, indicating a variant biochemical phenotype of Niemann-Pick disease type C (NPC)...
June 22, 2016: Rinshō Shinkeigaku, Clinical Neurology
Adrienne P Savant, Susanna A McColley
In this article, we highlight cystic fibrosis (CF) research published in Pediatric Pulmonology during 2015. Articles from other journals that reflect similar themes, and those of special importance, are also included. Pediatr Pulmonol. 2016;51:754-765. © 2016 Wiley Periodicals, Inc.
July 2016: Pediatric Pulmonology
Kiran Savant, Rakshit Vijay Sinai Khandeparker, Vikas Berwal, Purva Vijay Khandeparker, Hunny Jain
OBJECTIVES: To compare the efficacy of intravenous ondansetron (4 mg, 2 mL) and granisetron (2 mg, 2 mL) for preventing postoperative nausea and vomiting (PONV) in patients during oral and maxillofacial surgical procedures under general anesthesia. MATERIALS AND METHODS: A prospective, randomized, and double blind clinical study was carried out with 60 patients undergoing oral and maxillofacial surgical procedures under general anesthesia. Patients were divided into two groups of 30 individuals each...
April 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Antonio E Puente, Stephanie Heller, Angela Sekely
Although biological etiologies and diffuse anatomical changes have been provided as plausible explanations for the unusual behaviors observed in idiot savants, no neuropsychological case studies or explanations for these behaviors are found in the literature. We present a case in which the "diagnosis" of idiot savant was based on historical, clinical, and test data. To assess his calendar abilities, this individual was subsequently tested over a period of six months on his ability to determine the day of the week across approximately 1,000 years...
November 2016: Applied Neuropsychology. Adult
Piyush Kumar, Sushil S Savant, Anupam Das
Cutis laxa, clinically characterized by loose and pendulous skin related to loss of elastic tissue, is a rare heterogeneous condition. It is classified into congenital and acquired types. We report a case of generalized acquired cutis laxa type 1 in a young man following pruritic urticarial plaques. We have done a brief review of literature.
2016: Dermatology Online Journal
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