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Atopic dermatitis and food allergy

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https://www.readbyqxmd.com/read/28543769/perceptions-and-practices-regarding-atopic-dermatitis-a-survey
#1
Katherine R Grey, Kristen P Hook, Ingrid C Polcari, Sheilagh M Maguiness
Parents (N = 392) completed a survey at the Minnesota State Fair in August and September 2015 addressing knowledge regarding the pathogenesis of atopic dermatitis (AD), basic skin care practices, and the perceived role of infection and food allergies in AD. Of participating parents, 82% identified food allergy or sensitivity in AD pathogenesis, whereas only 42% identified bacterial infection as an important factor in AD severity. Participants most often received education on skin health from their pediatrician (49%), followed by Internet-based sources (23%), rather than a dermatologist or pediatric dermatologist...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28538875/particular-characteristics-of-atopic-eczema-in-tropical-environments-the-tropical-environment-control-for-chronic-eczema-and-molecular-assessment-teccema-cohort-study
#2
Jorge Sánchez, Andrés Sánchez, Ricardo Cardona
Background: Atopic dermatitis is a prevalent health problem in the world. Allergic sensitization is an important risk factor, but the roles of other factors, inherent in tropic region, are unknown. Objective: A cohort study was designed in a tropical city to investigate molecular and environmental risk factors for eczema, considering as particular features perennial exposure to mites, poor living conditions and others tropical characteristics. Methods: 433 patients were included at baseline and biological samples were collected during 24 months of follow-up...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#3
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28521317/mechanisms-of-tolerance-induction
#4
Anna Nowak-Węgrzyn, Pantipa Chatchatee
Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28477201/isolation-and-purification-of-th9-cells-for-the-study-of-inflammatory-diseases-in-research-and-clinical-settings
#5
Patricia Keating, James X Hartmann
Th9 cells are associated with atopic and inflammatory diseases, and their increased levels and function correlate with the severity of symptoms in various inflammatory disorders including asthma, food allergy, atopic dermatitis, ulcerative colitis, and psoriatic arthritis. Thus, clinical trials are warranted to evaluate the role of Th9 cells in allergic diseases with the goal of controlling these ailments.Circulating T cells (naïve or memory CD4+ T cells) purified from human blood and expanded using anti-CD3 and anti-CD28 antibodies can be treated with appropriate cytokines in order to polarize them to the Th9 phenotype as evidenced by their production of IL-9...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28432297/high-probability-of-comorbidities-in-bronchial-asthma-in-germany
#6
S Heck, S Al-Shobash, D Rapp, D D Le, A Omlor, A Bekhit, M Flaig, B Al-Kadah, W Herian, R Bals, S Wagenpfeil, Q T Dinh
Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany...
April 21, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28411833/atopic-dermatitis-and-comorbidities-added-value-of-comprehensive-dermatoepidemiology
#7
Tamar Nijsten
Atopic dermatitis is common and in its severe form is devastating. This chronic inflammatory dermatosis is part of the atopic syndrome, which includes asthma, food allergies, and hay fever and is known to be associated with mental health disorders. In line with psoriasis, several recent observational studies using national survey and linkage data have suggested a link between atopic dermatitis and cardiovascular disease. The atopic dermatitis field can benefit from the past experiences in psoriasis research and should not follow the same path, but, rather, aim for a more comprehensive approach from the beginning...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28392911/early-childhood-risk-factors-for-rhinoconjunctivitis-in-adolescence-a-prospective-birth-cohort-study
#8
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28390860/basophil-derived-interleukin-4-promotes-epicutaneous-antigen-sensitization-concomitant-with-the-development-of-food-allergy
#9
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated TSLP production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. While TSLP and basophils have been implicated to promote food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites such as the gastrointestinal tract are poorly understood...
April 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28375932/outstanding-animal-studies-in-allergy-ii-from-atopic-barrier-and-microbiome-to-allergen-specific-immunotherapy
#10
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal studies published within the past 18 months were assessed, focusing on innate and specific immunomodulation, providing knowledge of high translational relevance for human atopic and allergic diseases. RECENT FINDINGS: Allergic companion animals represent alternative models, but most studies were done in mice. Atopic dermatitis mouse models were refined by the utilization of cytokines like IL-23 and relevant skin allergens or enzymes. A novel IL-6 reporter mouse allows biomonitoring of inflammation...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28364406/component-resolved-diagnostics-in-thai-children-with-cow-s-milk-and-egg-allergy
#11
Wipa Jessadapakorn, Pasuree Sangsupawanich, Natthakul Wootipoom, Oranart Suddeaugrai, Araya Yuenyongviwat
BACKGROUND AND OBJECTIVE: Component-resolved diagnostics (CRD) have garnered a lot of attention in recent years in the diagnosis of food allergies. We aimed to investigate sensitization against cow's milk and egg white components, and to study the clinical usefulness of serum food-specific immunoglobulin E (sIgE) to cow's milk and egg white components in Thai children with cow's milk and egg allergies. METHOD: Children with IgE-mediated cow's milk and/or egg allergy were enrolled...
April 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28363401/neutrophilic-steroid-refractory-recurrent-wheeze-and-eosinophilic-steroid-refractory-asthma-in-children
#12
Tamazoust Guiddir, Philippe Saint-Pierre, Elsa Purenne-Denis, Nathalie Lambert, Yacine Laoudi, Rémy Couderc, Rahelé Gouvis-Echraghi, Flore Amat, Jocelyne Just
BACKGROUND: Little is known about inflammatory pathways of severe recurrent wheeze in preschool children and severe asthma in children. OBJECTIVES: The aim of the Severe Asthma Molecular Phenotype cohort was to characterize phenotypes of severe recurrent wheeze and severe asthma during childhood in terms of triggers (allergic or not), involved cells (eosinophil or neutrophil), and corticoid responsiveness. METHODS: Children with moderate-to-severe asthma and preschool children with moderate-to-severe recurrent wheeze were enrolled prospectively...
March 28, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28359274/allergic-diseases-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#13
Celine Miyazaki, Momoko Koyama, Erika Ota, Toshiyuki Swa, Linda B Mlunde, Rachel M Amiya, Yoshiyuki Tachibana, Kiwako Yamamoto-Hanada, Rintaro Mori
BACKGROUND: Reports of frequent manifestation of allergic diseases in children with attention deficit hyperactivity disorder (ADHD) have been the subject of mounting clinical interest. However, evidence supporting the association between ADHD and allergies is inconsistent and has yet to be systematically reviewed. The objective of this study was to compile and assess available studies on the association between ADHD and allergic diseases in children. METHODS: A comprehensive search using MEDLINE, EMBASE, the Cochrane library, and CINAHL databases was completed in 23 November 2015...
March 31, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28352197/development-of-an-allergy-management-support-system-in-primary-care
#14
Bertine Mj Flokstra-de Blok, Thys van der Molen, Wianda A Christoffers, Janwillem Wh Kocks, Richard L Oei, Joanne Ng Oude Elberink, Emmy M Roerdink, Marie Louise Schuttelaar, Jantina L van der Velde, Thecla M Brakel, Anthony Ej Dubois
BACKGROUND: Management of allergic patients in the population is becoming more difficult because of increases in both complexity and prevalence. Although general practitioners (GPs) are expected to play an important role in the care of allergic patients, they often feel ill-equipped for this task. Therefore, the aim of this study was to develop an allergy management support system (AMSS) for primary care. METHODS: Through literature review, interviewing and testing in secondary and primary care patients, an allergy history questionnaire was constructed by allergists, dermatologists, GPs and researchers based on primary care and specialists' allergy guidelines and their clinical knowledge...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28350555/apheresis-in-food-allergies
#15
Lamia Dahdah, Giovanna Leone, Mariacristina Artesani, Carla Riccardi, Oscar Mazzina
PURPOSE OF REVIEW: The prevalence of IgE-mediated food allergy and anaphylaxis has risen rapidly in developed countries, and countries with rapid industrialization may follow. Therapies include elimination diets, Oral ImmunoTherapy, and the administration of biologics, but high serum IgE levels may preclude their use. Consequently, decreasing IgE becomes a rational approach and could be obtained by immunoapheresis. The aim of this review is to evaluate the rationale and advantages of immunoapheresis...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28294587/vitamin-d-levels-and-allergic-diseases-an-italian-cross-sectional-multicenter-survey
#16
C Lombardi, G Passalacqua
Background. During the two last decades, the interest in the role of Vitamin D (VD) in allergic disease has increased. Apart from the well-known actions of VD in bone metabolism, recent studies suggested its possible role as an immune-modulator in allergy. Objective. This study, conducted over the Italian territory, evaluated the possible correlations between VD serum level and diagnosed allergic diseases (rhinitis / asthma, food allergy, atopic dermatitis). Thus, VD was assessed in patients with physician-diagnosed allergic diseases...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28285847/japanese-guidelines-for-food-allergy-2017
#17
REVIEW
Motohiro Ebisawa, Komei Ito, Takao Fujisawa
Five years have passed since the Japanese Pediatric Guideline for Food Allergy (JPGFA) was first revised in 2011 from its original version. As many scientific papers related to food allergy have been published during the last 5 years, the second major revision of the JPGFA was carried out in 2016. In this guideline, food allergies are generally classified into four clinical types: (1) neonatal and infantile gastrointestinal allergy, (2) infantile atopic dermatitis associated with food allergy, (3) immediate-type of food allergy (urticaria, anaphylaxis, etc...
April 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28270741/sensitization-to-secretoglobin-and-lipocalins-in-a-group-of-young-children-with-risk-of-developing-respiratory-allergy
#18
Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel, Takao Fujisawa
BACKGROUND: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development. METHODS: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28257972/the-microbiome-in-allergic-disease-current-understanding-and-future-opportunities-2017-practall-document-of-the-american-academy-of-allergy-asthma-immunology-and-the-european-academy-of-allergy-and-clinical-immunology
#19
Yvonne J Huang, Benjamin J Marsland, Supinda Bunyavanich, Liam O'Mahony, Donald Y M Leung, Antonella Muraro, Thomas A Fleisher
PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps...
April 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28257631/clinical-practice-recommendations-for-allergen-specific-immunotherapy-in-children-the-italian-consensus-report
#20
REVIEW
Giovanni Battista Pajno, Roberto Bernardini, Diego Peroni, Stefania Arasi, Alberto Martelli, Massimo Landi, Giovanni Passalacqua, Antonella Muraro, Stefania La Grutta, Alessandro Fiocchi, Luciana Indinnimeo, Carlo Caffarelli, Elisabetta Calamelli, Pasquale Comberiati, Marzia Duse
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy...
January 23, 2017: Italian Journal of Pediatrics
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