keyword
https://read.qxmd.com/read/38532427/exosomal-long-non-coding-rna-trpm2-as-promotes-angiogenesis-in-gallbladder-cancer-through-interacting-with-pabpc1-to-activate-notch1-signaling-pathway
#1
JOURNAL ARTICLE
Zhiqiang He, Yuhan Zhong, Parbatraj Regmi, Tianrun Lv, Wenjie Ma, Junke Wang, Fei Liu, Siqi Yang, Yanjie Zhong, Rongxing Zhou, Yanwen Jin, Nansheng Cheng, Yujun Shi, Haijie Hu, Fuyu Li
BACKGROUND: Abnormal angiogenesis is crucial for gallbladder cancer (GBC) tumor growth and invasion, highlighting the importance of elucidating the mechanisms underlying this process. LncRNA (long non-coding RNA) is widely involved in the malignancy of GBC. However, conclusive evidence confirming the correlation between lncRNAs and angiogenesis in GBC is lacking. METHODS: LncRNA sequencing was performed to identify the differentially expressed lncRNAs. RT-qPCR, western blot, FISH, and immunofluorescence were used to measure TRPM2-AS and NOTCH1 signaling pathway expression in vitro...
March 27, 2024: Molecular Cancer
https://read.qxmd.com/read/38528705/exosomal-circ_0000735-contributes-to-non-small-lung-cancer-malignant-progression
#2
JOURNAL ARTICLE
Sijie Liu, Xun Wu, Yanjie Wang, Yingtai Chen
Circular RNA is an important regulator for non-small cell lung cancer (NSCLC). Circ_0000735 has been found to be significantly overexpressed in NSCLC tissues. Therefore, its role and mechanism in NSCLC progression need to be further explored. The expression levels of circ_0000735, miR-345-5p and A disintegrin and metalloprotease 19 (ADAM19) were determined using quantitative real-time PCR. EdU staining, wound healing and transwell assays were utilized to detect cell proliferation and metastasis. The protein levels of metastasis markers, exosome markers and ADAM19 were determined using western blot...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38515178/auranofin-repurposing-for-lung-and-pancreatic-cancer-low-ca12-expression-as-a-marker-of-sensitivity-in-patient-derived-organoids-with-potentiated-efficacy-by-akt-inhibition
#3
JOURNAL ARTICLE
Christophe Deben, Laurie Freire Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz, Maxim Le Compte, Sofie Seghers, Marc Peeters, Steve Vanlanduit, Abraham Lin, Krijn K Dijkstra, Paul Van Schil, Jeroen M H Hendriks, Hans Prenen, Geert Roeyen, Filip Lardon, Evelien Smits
BACKGROUND: This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cost-effective and time-efficient approach to developing new cancer therapies. Our research focuses on evaluating AF's selective cytotoxicity against cancer cells, identifying RNAseq-based biomarkers to predict AF response, and finding the most effective co-therapeutic agents for combination with AF...
March 22, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38514598/revealing-a-novel-methylated-integrin-alpha-8-related-to-extracellular-matrix-and-anoikis-resistance-using-proteomic-analysis-in-the-immune-microenvironment-of-lung-adenocarcinoma
#4
JOURNAL ARTICLE
Tingting Liu, Wen Ji, Xue Cheng, Lin Lv, Xiaohui Yu, Na Wang, Mengcong Li, Tinghua Hu, Zhihong Shi
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes associated with ECM and constructed immune risk-related prognosis model in LUAD. We downloaded mRNAs transcriptome data, miRNAs expression data, and clinical patient information for LUAD based on The Cancer Genome Atlas. "Limma, clusterProfiler, ggplot2" R packages and GSEA were used to analyze meaningful genes and explore potential biological function...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38502426/the-impact-of-prior-single-gene-testing-on-comprehensive-genomic-profiling-results-for-patients-with-non-small-cell-lung-cancer
#5
JOURNAL ARTICLE
Mary K Nesline, Vivek Subbiah, Rebecca A Previs, Kyle C Strickland, Heidi Ko, Paul DePietro, Michael D Biorn, Maureen Cooper, Nini Wu, Jeffrey Conroy, Sarabjot Pabla, Shengle Zhang, Zachary D Wallen, Pratheesh Sathyan, Kamal Saini, Marcia Eisenberg, Brian Caveney, Eric A Severson, Shakti Ramkissoon
INTRODUCTION: Tissue-based broad molecular profiling of guideline-recommended biomarkers is advised for the therapeutic management of patients with non-small cell lung cancer (NSCLC). However, practice variation can affect whether all indicated biomarkers are tested. We aimed to evaluate the impact of common single-gene testing (SGT) on subsequent comprehensive genomic profiling (CGP) test outcomes and results in NSCLC. METHODS: Oncologists who ordered SGT for guideline-recommended biomarkers in NSCLC patients were prospectively contacted (May-December 2022) and offered CGP (DNA and RNA sequencing), either following receipt of negative SGT findings, or instead of SGT for each patient...
March 19, 2024: Oncology and Therapy
https://read.qxmd.com/read/38501058/role-of-circular-rnas-in-lung-cancer
#6
REVIEW
Maksat Babayev, Patricia Silveyra
Lung cancer remains a global public health concern with significant research focus on developing better diagnosis/prognosis biomarkers and therapeutical targets. Circular RNAs (circRNAs) are a type of single-stranded RNA molecules that covalently closed and have ubiquitous expression. These molecules have been implicated in a variety of disease mechanisms, including lung cancer, as they exhibit oncogenic or tumor suppressor characteristics. Recent research has shown an important role that circRNAs play at different stages of lung cancer, particularly in lung adenocarcinoma...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38496877/genetic-mutation-profiling-reveals-biomarkers-for-targeted-therapy-efficacy-and-prognosis-in-non-small-cell-lung-cancer
#7
JOURNAL ARTICLE
Hao Bai, Yan Zhou, Wanting Liu, Wang-Yang Xu, Lei Cheng, Yingying Huo, Hao Ji, Liwen Xiong
INTRODUCTION: The genetic heterogeneity of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ( EGFR ) mutations may affect clinical responses and outcomes to EGFR tyrosine kinase inhibitors (EGFR-TKIs). This study aims to investigate the genomic factors that influence the efficacy and clinical outcomes of first-line, second-line and third-line treatments in NSCLC and explore the heterogeneity of resistance mechanisms. MATERIALS AND METHODS: This real-world study comprised 65 patients with EGFR mutant NSCLC...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496687/pd-l1-mrna-derived-from-tumor-educated-platelets-as-a-potential-immunotherapy-biomarker-in-non-small-cell-lung-cancer
#8
JOURNAL ARTICLE
Zhihuang Hu, Na Wang, Yao Zhang, Daoyun Zhang, Si Sun, Hui Yu, Ying Lin, Xinmin Zhao, Huijie Wang, Xianghua Wu, Yoshinobu Ichiki, Satoshi Watanabe, Ziying Gong, Jianhua Chang, Jialei Wang
BACKGROUND: To date, the role of programmed death ligand-1 (PD-L1) messenger RNA (mRNA) derived from tumor-educated platelets (TEPs) has not been well investigated in patients with advanced non-small cell lung cancer (NSCLC). A few reports have examined whether mRNA in TEPs can predict the clinical responses of patients with advanced NSCLC following immunotherapy. This study aimed to identify novel biomarkers to improve the clinical benefits and outcomes of NSCLC patients. METHODS: Advanced NSCLC patients receiving a combination of immunotherapy and chemotherapy, or immunotherapy alone as a first- or second-line treatment at the Fudan University Shanghai Cancer Center were enrolled in this study...
February 29, 2024: Translational Lung Cancer Research
https://read.qxmd.com/read/38495494/systematic-analysis-to-identify-the-mir99ahg-has-mir-21-5p-ehd1-cerna-regulatory-network-as-potential-biomarkers-in-lung-cancer
#9
JOURNAL ARTICLE
Mengju He, Hui Zhang, Yanfei Zhang, Yicen Ding, Fei Zhang, Yani Kang
Lung cancer (LC) remains an extremely lethal disease worldwide, and effective prognostic biomarkers are at top priority. With the rapid development of high-throughput sequencing and bioinformatic analysis methods, the quest to characterize cancer transcriptomes continues to move forward. However, the integrated systematic analysis of lncRNA-miRNA-mRNA regulatory network in LC is lacking. In this study, we collected samples of cancer tissues and adjacent normal tissues from patients with lung cancer and conducted transcriptome and small RNA sequencing to identify differentially expressed genes (DEGs), miRNAs (DEMs), and lncRNAs (DELs)...
2024: Journal of Cancer
https://read.qxmd.com/read/38493517/predictive-value-of-peripheral-blood-leukocytes-based-methylation-of-long-non-coding-rna-malat1-and-h19-in-the-chemotherapy-effect-and-prognosis-of-gastric-cancer
#10
JOURNAL ARTICLE
Fang Wang, Dingtao Hu, Xiaoqi Lou, Linlin Wang, Yuhua Wang, Tingyu Zhang, Ziye Yan, Nana Meng, Yu Lei, Yanfeng Zou
BACKGROUND: The predictive value of the methylation of Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and H19 promoters in peripheral blood leukocytes as a non-invasive biomarker for the chemotherapy effect and prognosis gastric cancer (GC) is unclear. METHODS: The DNA methylation of H19 and MALAT1 between chemotherapy-sensitive and non-sensitive groups and between groups with better and worse survival of GC was compared using regression analyses...
March 16, 2024: Translational Oncology
https://read.qxmd.com/read/38481861/long-noncoding-rna-gprc5d-as1-in-renal-cell-carcinoma-a-molecular-mechanism-study
#11
JOURNAL ARTICLE
Mingfei Jia, Xi Chen, Shaosan Kang, Fenghong Cao, Yansheng Zhao, Liguo Zhang, Xinghua Bao, Lei Wang, Hengran Li, Chenggang Li
BACKGROUND: Clear cell renal cell carcinoma (RCC) is the most common subtype of RCC. Although targeted therapy can provide superior treatment outcomes, it is prone to drug resistance, and individual responses to immunotherapy vary greatly. Therefore, finding new diagnostic and therapeutic targets for RCC is of considerable importance. Long noncoding RNA (lncRNA) GPRC5D-AS1 can serve as a biomarker in clinical applications and the prognosis of lung squamous cell carcinoma. However, the specific mechanism of action of lncRNA GPRC5D-AS1 in RCC has not yet been clarified...
February 29, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38476239/glipr2-a-potential-biomarker-and-therapeutic-target-unveiled-insights-from-extensive-pan-cancer-analyses-with-a-spotlight-on-lung-adenocarcinoma
#12
MULTICENTER STUDY
Wei Lin, Siming Zhang, Chunyan Gu, Haixia Zhu, Yuan Liu
BACKGROUND: Glioma pathogenesis related-2 (GLIPR2), an emerging Golgi membrane protein implicated in autophagy, has received limited attention in current scholarly discourse. METHODS: Leveraging extensive datasets, including The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx), Human Protein Atlas (HPA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC), we conducted a comprehensive investigation into GLIPR2 expression across diverse human malignancies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38475971/cellular-and-clinical-impact-of-protein-phosphatase-enzyme-epigenetic-silencing-in-multiple-cancer-tissues
#13
JOURNAL ARTICLE
Edward Wiltshire, Manuel Castro de Moura, David Piñeyro, Ricky S Joshi
BACKGROUND: Protein Phosphatase Enzymes (PPE) and protein kinases simultaneously control phosphorylation mechanisms that tightly regulate intracellular signalling pathways and stimulate cellular responses. In human malignancies, PPE and protein kinases are frequently mutated resulting in uncontrolled kinase activity and PPE suppression, leading to cell proliferation, migration and resistance to anti-cancer therapies. Cancer associated DNA hypermethylation at PPE promoters gives rise to transcriptional silencing (epimutations) and is a hallmark of cancer...
March 12, 2024: Human Genomics
https://read.qxmd.com/read/38473263/expanding-broad-molecular-reflex-testing-in-non-small-cell-lung-cancer-to-squamous-histology
#14
JOURNAL ARTICLE
Martin Zacharias, Selma Konjic, Nikolaus Kratochwill, Gudrun Absenger, Angelika Terbuch, Philipp J Jost, Robert Wurm, Jörg Lindenmann, Karl Kashofer, Franz Gollowitsch, Gregor Gorkiewicz, Luka Brcic
Due to the success story of biomarker-driven targeted therapy, most NSCLC guidelines agree that molecular reflex testing should be performed in all cases with non-squamous cell carcinoma (non-SCC). In contrast, testing recommendations for squamous cell carcinoma (SCC) vary considerably, specifically concerning the exclusion of patients of certain age or smoking status from molecular testing strategies. We performed a retrospective single-center study examining the value of molecular reflex testing in an unselected cohort of 316 consecutive lung SCC cases, tested by DNA- and RNA-based next-generation sequencing (NGS) at our academic institution between 2019 and 2023...
February 23, 2024: Cancers
https://read.qxmd.com/read/38470324/thermophoretic-aggregation-imaging-of-tumor-derived-exosomes-by-crispr-cas13a-based-nanoprobes
#15
JOURNAL ARTICLE
Ping Zhou, Yingbo Pan, Bo Liu, Wei Pan, Na Li, Bo Tang
The inherent heterogeneity of tumor-derived exosomes holds great promise for enhancing the precision of cancer diagnostics. MicroRNAs (miRNAs) encapsulated in tumor-associated exosomes have emerged as valuable biomarkers for the early detection of cancers. Nevertheless, the flexible structure and inherent instability of RNA limit its application in biological diagnostics. The CRISPR-Cas13a system, distinguished by its target-responsive "collateral effect", represents a powerful tool for advancing cancer diagnostics...
March 12, 2024: Analytical Chemistry
https://read.qxmd.com/read/38469708/upregulation-of-ly6k-induced-by-fto-mediated-demethylation-promotes-the-tumorigenesis-and-metastasis-of-oral-squamous-cell-carcinoma-via-cav-1-mediated-erk1-2-signaling-activation
#16
JOURNAL ARTICLE
Rujuan Gong, Chen Xu, Haibing Yang
Lymphocyte antigen 6 complex locus K (LY6K) has been demonstrated to play a significant role in cancers and identified as a therapeutic biomarker for head and neck squamous cell carcinoma. However, the role of LY6K in oral squamous cell carcinoma (OSCC) has not been explored. The current study discovered that LY6K was aberrantly upregulated in OSCC cell lines and tissues and that high LY6K expression significantly correlated with poorer survival of OSCC patients. Through stable knockdown of LY6K, we found that the growth, colony formation, migration, and invasion of OSCC cells were substantially suppressed...
February 27, 2024: Histology and Histopathology
https://read.qxmd.com/read/38463883/clec4e-upregulation-in-gastric-cancer-a-potential-therapeutic-target-correlating-with-tumor-associated-macrophages
#17
JOURNAL ARTICLE
Qin Jiang, Dan Xiao, Ao Wang, Qiong Yu, Ying Yin, Jingchong Wu, Yan Zhang, Tian Jin, Baicheng Kuang, Yegui Jia
BACKGROUND: CLEC4E has been reported to promote lung cancer progression. Tumor-associated macrophages (TAMs) play an important role in tumorigenesis. Whether the expression of CLEC4E in TAMs is associated with gastric carcinogenesis remains unclear. METHODS: The TIMER, UALCAN, UCSC Xena, and KM plotter databases are used to examine the expression of CLEC4E and its prognostic significance in gastric cancer (GC). Additionally, GO, KEGG, and GSEA analysis were conducted, and single-cell RNA-seq (scRNA-seq) datasets were utilized...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463866/identification-of-immune-related-gene-signature-for-non-small-cell-lung-cancer-patients-with-immune-checkpoint-inhibitors
#18
JOURNAL ARTICLE
Li Wang, Chaonan Han, Chenlei Cai, Jing Wu, Jianing Chen, Chunxia Su
BACKGROUND: The utilization of immune checkpoint inhibitors (ICIs) has become the established protocol for treating advanced non-small cell lung cancer (NSCLC). This work aimed to identify the immune-related gene signature that can predict the prognosis of NSCLC patients receiving ICI treatment. METHODS: The ImmPort database was queried to obtain a list of immune-related genes (IRGs). Differentially expressed IRGs in NSCLC patients were identified using the TCGA database...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463169/comparison-of-rna-seq-and-microarray-in-the-prediction-of-protein-expression-and-survival-prediction
#19
JOURNAL ARTICLE
Won-Ji Kim, Bo Ram Choi, Joseph J Noh, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Chel Hun Choi
Gene expression profiling using RNA-sequencing (RNA-seq) and microarray technologies is widely used in cancer research to identify biomarkers for clinical endpoint prediction. We compared the performance of these two methods in predicting protein expression and clinical endpoints using The Cancer Genome Atlas (TCGA) datasets of lung cancer, colorectal cancer, renal cancer, breast cancer, endometrial cancer, and ovarian cancer. We calculated the correlation coefficients between gene expression measured by RNA-seq or microarray and protein expression measured by reverse phase protein array (RPPA)...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38460436/multi-targeted-therapeutic-potential-of-stigmasterol-from-the-euphorbia-ammak-plant-in-treating-lung-and-breast-cancer
#20
JOURNAL ARTICLE
Othman Baothman, Ehab M M Ali, Salman Hosawi, Emadeldin Hassan E Konozy, Isam M Abu Zeid, Abrar Ahmad, Hisham N Altayb
Cancer is the most prevalent disease globally, which presents a significant challenge to the healthcare industry, with breast and lung cancer being predominant malignancies. This study used RNA-seq data from the TCGA database to identify potential biomarkers for lung and breast cancer. Tumor Necrosis Factor (TNFAIP8) and Sulfite Oxidase (SUOX) showed significant expression variation and were selected for further study using structure-based drug discovery (SBDD). Compounds derived from the Euphorbia ammak plant were selected for in-silico study with both TNFAIP8 and SUOX...
February 28, 2024: Computational Biology and Chemistry
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