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bledding in cardiac surgery with cardiopulmonary bypass

Michelle K Brenner, Shanelle Clarke, Donna K Mahnke, Pippa Simpson, Rachel S Bercovitz, Aoy Tomita-Mitchell, Michael E Mitchell, Debra K Newman
BACKGROUND: Postsurgical bleeding causes significant morbidity and mortality in children undergoing surgery for congenital heart defects (CHD). 22q11.2 deletion syndrome (DS) is the second most common genetic risk factor for CHD. The deleted segment of chromosome 22q11.2 encompasses the gene encoding glycoprotein (GP) Ibβ, which is required for expression of the GPIb-V-IX complex on the platelet surface, where it functions as the receptor for von Willebrand factor (VWF). Binding of GPIb-V-IX to VWF is important for platelets to initiate hemostasis...
February 2016: Pediatric Research
Chiara Giorni, Zaccaria Ricci, Francesca Iodice, Cristiana Garisto, Isabella Favia, Angelo Polito, Adriano Carotti, Paola Cogo
Bleeding during and after cardiac surgery is a major issue in pediatric patients. A prospective cohort study was conducted to evaluate the effect of a commercially available prothrombin complex (Confidex) administered in cardiac surgery after weaning from cardiopulmonary bypass of infants with nonsurgical bleeding. In this study, 14 patients younger than 1 year received a Confidex bolus and were matched with 11 patients of a similar age who did not receive the drug. The preoperative coagulation profile was similar in the two groups...
February 2014: Pediatric Cardiology
Ian J Welsby, Mihai V Podgoreanu, Barbara Phillips-Bute, Richard Morris, Joseph P Mathew, Peter K Smith, Mark F Newman, Debra A Schwinn, Mark Stafford-Smith
OBJECTIVE: Hemorrhage continues to be a major problem after cardiac surgery despite the routine use of antifibrinolytic drugs, with striking inter-patient variability poorly explained by already known risk factors. The authors tested the hypothesis that genetic polymorphisms of inflammatory mediators and cellular adhesion molecules are associated with bleeding after cardiac surgery. DESIGN: Prospective, observational study. SETTING: Single, tertiary referral university heart center...
June 2010: Journal of Cardiothoracic and Vascular Anesthesia
S Manikappa, Y Mehta, R Juneja, N Trehan
This study was conducted to determine the use of thromboelastograph in predicting excessive postoperative bleeding, detecting coagulopathy related bleeding, reducing usage of blood and blood products and aiding reexploration decisions. One hundred fifty patients undergoing coronary artery bypass graft surgery under cardiopulmonary bypass were randomized and studied prospectively in two equal groups. In the study group, celite activated heparinase pretreated blood samples, 30 minutes after protamine administration were subjected to thromboelastographic analysis and blood and blood component therapy was administered based on thromboelastograph values, if they had significant bleeding...
January 2001: Annals of Cardiac Anaesthesia
Paolo G Merlani, Catherine Chenaud, Silvia Cottini, Guido Reber, Philippe Garnerin, Philippe de Moerloose, Bara Ricou
OBJECTIVES: Determination of activated partial thromboplastin time (aPTT) is used in coagulation management after heart surgery. Results from the central laboratory take long to be obtained. We sought to shorten the time to obtain coagulation results and the desired coagulation state and to reduce blood loss and transfusions using point of care (POC) aPTT determination. DESIGN: Randomized, controlled trial. SETTING: University-affiliated 20-bed surgical ICU...
September 2006: Intensive Care Medicine
George M Palatianos, Christophoros N Foroulis, Maria I Vassili, Phaedra Matsouka, George M Astras, George H Kantidakis, Eugenia Iliopoulou, Efthimia N Melissari
OBJECTIVE: The objective of this study was to evaluate our protocol for the identification and management of patients with immune heparin-induced thrombocytopenia undergoing cardiac surgery. METHODS: Among 1518 patients who underwent cardiac surgery between June 1998 and May 2001, 32 (2.1%) presented with platelet counts less than 150,000/mm3 preoperatively or a history of prolonged (>3 days) intravenous exposure to heparin or both. These 32 patients were evaluated with an enzyme-linked immunosorbent assay for antibodies against heparin-platelet factor 4 complex...
February 2004: Journal of Thoracic and Cardiovascular Surgery
F Forestier, A Coiffic, C Mouton, D Ekouevi, G Chêne, G Janvier
BACKGROUND: Platelet dysfunction is an important cause of excessive bleeding after cardiac surgery. We assessed two platelet function point-of-care tests: the platelet function analyser (PFA-100) and the Hemostatus(TM) in patients with and without excessive bleeding after cardiac surgery with cardiopulmonary bypass. METHODS: Mediastinal chest tube drainage (MCTD) was measured for the first 6 h in the intensive care unit (ICU). Haematology and coagulation tests were done on arrival in the ICU, and when excessive bleeding occurred (MCTD >1 ml kg(-1) h(-1)) or after 3 h...
November 2002: British Journal of Anaesthesia
F Forestier, S Bélisle, D Robitaille, R Martineau, L P Perrault, J F Hardy
BACKGROUND: Uncontrolled clinical experience at our institution suggested that low-dose aprotinin could control excessive bleeding after cardiopulmonary bypass (CPB). A randomized clinical trial was conducted to determine the efficacy of low-dose aprotinin in the treatment of hemorrhage after cardiac surgery. METHODS: One hundred seventy-one patients undergoing cardiac surgery with CPB were included. Forty-four patients (26%) bled significantly in the intensive care unit (>100 mL/h) and received either aprotinin (200,000 KIU bolus + 100,000 KIU/h for 8 hours) or placebo in addition to our standard management of excessive bleeding...
February 2000: Annals of Thoracic Surgery
F M Silveira, D M Lourenço, M Maluf, W B Carvalho, E Buffolo, A C Carvalho
PURPOSE: We evaluated hemostasic changes in children undergoing open heart surgery with cardiopulmonary bypass (CPB). METHODS: We studied 17 children before, during surgery, in the immediate, first and between the 4th and 7th postoperative days, measuring hematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen, platelet count, factor V and euglobulin lysis time. Children were divided in those with and without excessive bleeding in the postoperative period...
January 1998: Arquivos Brasileiros de Cardiologia
L O Heikkinen, K V Ala-Kulju
Open-heart surgery was performed on 1686 adult patients between 1980 and 1984, with a mortality rate due to abdominal complications of 0.6%. Every operation involved the use of cardiopulmonary bypass (CPB). Abdominal complications occurred in 1.6%, with an overall mortality rate of 36%. The most frequent complication was gastrointestinal (Gl) bleeding (61%). The mortality of the patients who bled from the Gl tract was 53%. Other complications encountered were gastroduodenal ulcer, colitis, ileus, subphrenic abscess and intraperitoneal bleeding...
1987: Scandinavian Journal of Thoracic and Cardiovascular Surgery
M Weinstein, J A Ware, J Troll, E Salzman
Patients who receive desmopressin acetate (dDAVP) after cardiopulmonary bypass bleed less during operation and in the first 24 hours after operation than do patients who receive a placebo. To study the mechanism of improved hemostasis in bypass patients, we examined the relationship between von Willebrand factor (vWF) and blood loss in 70 cardiopulmonary bypass patients, one-half of whom received desmopressin intraoperatively. vWF concentration and multimeric composition were analyzed before and after bypass, after drug treatment, and 24 hours after operation...
June 1988: Blood
J N Cunningham, F C Spencer, R Zeff, C D Williams, R Cukingnan, M Mullin
Experiences with primary closure of the pericardium in a series of 100 patients undergoing open-heart operations are described. The pericardium was kept under tension during the operation to minimize shrinkage and permit closure at the end of the procedure. In 28 patients one pleural space was opened for drainage, whereas in 72 patients intra- and extrapericardial sumps alone were used for drainage. Measurements of sump drainage revealed that most postoperative bleeding originates from outside the pericardium...
July 1975: Journal of Thoracic and Cardiovascular Surgery
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