keyword
https://read.qxmd.com/read/38531200/ischemia-inhibited-ferric-chelate-reductase-1-improves-ferroptosis-mediated-intestinal-ischemia-injury-via-hippo-signaling
#1
JOURNAL ARTICLE
Pengzhen Liang, Wei Xie, Xing Wang, Zhaohui Du, Chuanming Zheng, Hongchang Zhao, Zhenjie Wang, Zhong Ji
The precise mechanism of ferroptosis as a regulatory cell death in intestinal ischemia injury induced by vascular intestinal obstruction (Vio) remains to be elucidated. Here, we evaluated iron levels, glutathione peroxidase 4 (GPX4) and Acyl-CoA synthetase long-chain family member 4 (ACSL4) changes after intestinal ischemia injury to validate ferroptosis. As an enzyme for Fe3+ reduction to Fe2+ , Ferric Chelate Reductase 1 (FRRS1) is involved in the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38528655/cannabidiol-modulates-hippocampal-genes-involved-in-mitochondrial-function-ribosome-biogenesis-synapse-organization-and-chromatin-modifications
#2
JOURNAL ARTICLE
João P D Machado, Valéria de Almeida, Antonio W Zuardi, Jaime E C Hallak, José A Crippa, André S Vieira
BACKGROUND: Cannabidiol (CBD) is one of the main cannabinoids present in Cannabis sativa female flowers. Previous investigation has already provided insights into the CBD molecular mechanism, however, there is no transcriptome data for CBD effects on hippocampal subfields. Here, we investigate transcriptomic changes in dorsal and ventral CA1 of adult mice hippocampus after 100 mg/kg of CBD administration (i.p.) for one or seven consecutive days. METHODS: C57BL/6JUnib mice were treated with either vehicle or CBD for 1 or 7 days...
March 26, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38526156/emerging-mechanisms-in-the-redox-regulation-of-mitochondrial-cytochrome-c-oxidase-assembly-and-function
#3
JOURNAL ARTICLE
Suleva Povea-Cabello, Michele Brischigliaro, Erika Fernández-Vizarra
In eukaryotic cells, mitochondria perform cellular respiration through a series of redox reactions ultimately reducing molecular oxygen to water. The system responsible for this process is the respiratory chain or electron transport system (ETS) composed of complexes I-IV. Due to its function, the ETS is the main source of reactive oxygen species (ROS), generating them on both sides of the mitochondrial inner membrane, i.e. the intermembrane space (IMS) and the matrix. A correct balance between ROS generation and scavenging is important for keeping the cellular redox homeostasis and other important aspects of cellular physiology...
March 25, 2024: Biochemical Society Transactions
https://read.qxmd.com/read/38524433/alternative-oxidase-from-molecule-and-function-to-future-inhibitors
#4
REVIEW
Jiye Li, Shiyun Yang, Yujie Wu, Ruina Wang, Yu Liu, Jiacun Liu, Zi Ye, Renjie Tang, Malcolm Whiteway, Quanzhen Lv, Lan Yan
In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase (AOX) functions as the terminal oxidase and has important roles in maintaining metabolic and signaling homeostasis in mitochondria. AOX endows the respiratory system with flexibility in the coupling among the carbon metabolism pathway, electron transport chain (ETC) activity, and ATP turnover. AOX allows electrons to bypass the main cytochrome pathway to restrict the generation of reactive oxygen species (ROS). The inhibition of AOX leads to oxidative damage and contributes to the loss of adaptability and viability in some pathogenic organisms...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38508182/synchronized-assembly-of-the-oxidative-phosphorylation-system-controls-mitochondrial-respiration-in-yeast
#5
JOURNAL ARTICLE
Daiana N Moretti-Horten, Carlotta Peselj, Asli Aras Taskin, Lisa Myketin, Uwe Schulte, Oliver Einsle, Friedel Drepper, Marcin Luzarowski, F-Nora Vögtle
Control of protein stoichiometry is essential for cell function. Mitochondrial oxidative phosphorylation (OXPHOS) presents a complex stoichiometric challenge as the ratio of the electron transport chain (ETC) and ATP synthase must be tightly controlled, and assembly requires coordinated integration of proteins encoded in the nuclear and mitochondrial genome. How correct OXPHOS stoichiometry is achieved is unknown. We identify the MitochondrialRegulatory hub for respiratoryAssembly (MiRA) platform, which synchronizes ETC and ATP synthase biogenesis in yeast...
March 18, 2024: Developmental Cell
https://read.qxmd.com/read/38506566/evidence-for-trans-oligoene-chain-formation-in-graphene-induced-by-iodine
#6
JOURNAL ARTICLE
Fabian Grote, Benjamin I Weintrub, Mira Kreßler, Qing Cao, Christian E Halbig, Patryk Kusch, Kirill I Bolotin, Siegfried Eigler
Functionalization of pristine graphene by hydrogen and fluorine is well studied, resulting in graphane and fluorographene structures. In contrast, functionalization of pristine graphene with iodine has not been reported. Here, the functionalization of graphene with iodine using photochemical activation is presented, which is thermally reversible at 400 °C. Additional dispersive dominant Raman modes that are probed by resonance Raman spectroscopy are observed. Additionally, iodinated graphene is probed by Kelvin probe force microscopy and by transport measurements showing p-doping surpassing non-covalent iodine doping by charge transfer-complex formation...
March 20, 2024: Small
https://read.qxmd.com/read/38501271/low-hysteresis-zwitterionic-supramolecular-polymer-ion-conductive-elastomers-with-anti-freezing-properties-high-stretchability-and-self-adhesion-for-flexible-electronic-devices
#7
JOURNAL ARTICLE
Hongying Wang, Baocheng Liu, Danyang Chen, Zhuoya Wang, Haolun Wang, Siyu Bao, Ping Zhang, Jianhai Yang, Wenguang Liu
The fabrication of stretchable ionic conductors with low hysteresis and anti-freezing properties to enhance the durability and reliability of flexible electronics even at low temperatures remains an unmet challenge. Here, we report a facile strategy to fabricate low hysteresis, high stretchability, self-adhesion and anti-freezing zwitterionic supramolecular polymer ion-conductive elastomers (ICEs) by photoinitiated polymerization of aqueous precursor solutions containing a newly designed zwitterionic monomer carboxybetaine ureido acrylate (CBUIA) followed by solvent evaporation...
March 19, 2024: Materials Horizons
https://read.qxmd.com/read/38499440/blood-brain-barrier-penetrating-nanovehicles-for-interfering-with-mitochondrial-electron-flow-in-glioblastoma
#8
JOURNAL ARTICLE
Yulin Zhang, Kaiyan Xi, Yuying Zhang, Zezheng Fang, Yi Zhang, Kaijie Zhao, Fan Feng, Jianyu Shen, Mingrui Wang, Runlu Zhang, Bo Cheng, Huimin Geng, Xingang Li, Bin Huang, Kang-Nan Wang, Shilei Ni
Glioblastoma multiforme (GBM) is the most aggressive and lethal form of human brain tumors. Dismantling the suppressed immune microenvironment is an effective therapeutic strategy against GBM; however, GBM does not respond to exogenous immunotherapeutic agents due to low immunogenicity. Manipulating the mitochondrial electron transport chain (ETC) elevates the immunogenicity of GBM, rendering previously immune-evasive tumors highly susceptible to immune surveillance, thereby enhancing tumor immune responsiveness and subsequently activating both innate and adaptive immunity...
March 18, 2024: ACS Nano
https://read.qxmd.com/read/38494143/tigar-reduces-neuronal-ferroptosis-by-inhibiting-succinate-dehydrogenase-activity-in-cerebral-ischemia
#9
JOURNAL ARTICLE
Xinxin Wang, Mei Li, Fan Wang, Guanghui Mao, Junchao Wu, Rong Han, Rui Sheng, Zhenghong Qin, Hong Ni
Ischemia Stroke (IS) is an acute neurological condition with high morbidity, disability, and mortality due to a severe reduction in local cerebral blood flow to the brain and blockage of oxygen and glucose supply. Oxidative stress induced by IS predisposes neurons to ferroptosis. TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits the intracellular glycolytic pathway to increase pentose phosphate pathway (PPP) flux, promotes NADPH production and thus generates reduced glutathione (GSH) to scavenge reactive oxygen species (ROS), and thus shows strong antioxidant effects to ameliorate cerebral ischemia/reperfusion injury...
March 15, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38493916/coenzyme-q10-in-atherosclerosis
#10
REVIEW
Minjun Liao, Xueke He, Yangyang Zhou, Weiqiang Peng, Xiao-Mei Zhao, Miao Jiang
Atherosclerotic disease is a chronic disease that predominantly affects the elderly and is the most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to processes such as abnormal lipid transport and metabolism, impaired endothelial function, inflammation, and oxidative stress. Coenzyme Q10 (CoQ10) is a key component of complex Ⅰ in the electron transport chain and an important endogenous antioxidant that may play a role in decelerating the progression of atherosclerosis...
March 15, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38493904/ginkgo-biloba-l-exocarp-petroleum-ether-extract-inhibits-methicillin-resistant-staphylococcus-aureus-by-modulating-ion-transport-virulence-and-biofilm-formation-in-vitro-and-in-vivo
#11
JOURNAL ARTICLE
Peng-Wei Wei, Xu Wang, Cong Wang, Ming Chen, Meng-Zhu Liu, Wen-Xia Liu, Yan-Ling He, Guo-Bo Xu, Xiao-He Zheng, Hua Zhang, Hong-Mei Liu, Bing Wang
ETHNOPHARMACOLOGICAL RELEVANCE: As reported in the Ancient Chinese Medicinal Books, Ginkgo biloba L. fruit has been used as a traditional Chinese medicine for the treatment asthma and cough or as a disinfectant. Our previous study demonstrated that G. biloba exocarp extract (GBEE), an extract of a traditional Chinese herb, inhibits the formation of methicillin-resistant Staphylococcus aureus (MRSA) biofilms. However, GBEE is a crude extract that contains many components, and the underlying mechanisms of purified GBEE fractions extracted with solvents of different polarities are unknown...
March 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38491646/nonlinear-charge-and-energy-transport-in-anharmonic-quasi-two-dimensional-systems
#12
JOURNAL ARTICLE
Luis A Cisneros-Ake, Larissa Brizhik, Julián T Becerra-Sagredo, Manuel G Velarde
We study the localized states of an extra electron in an anisotropic quasi-two-dimensional system in which the electron-lattice interaction and the anharmonicity of the lattice vibrations are dominant in one direction. This model describes layers of polydiacetylene or other polymer chains, beta sheets of polypeptides, multilevel microstructures of conjugated polymers, and other low-dimensional systems. It is shown that for appropriate parameter values of the system an extra electron can excite a soliton-like mobile wave of the lattice deformation, within which it can get self-trapped...
February 2024: Physical Review. E
https://read.qxmd.com/read/38488751/assessment-of-mitochondrial-function-in-the-ame-711-honey-bee-cell-line-boscalid-and-pyraclostrobin-effects
#13
JOURNAL ARTICLE
Dalma Martinović-Weigelt, Minh-Anh Dang, Alex Mord, Michael J Goblirsch
There is a growing concern that chronic exposure to fungicides contributes to negative effects on honey bee development, life span, and behavior. Field and caged-bee studies have helped to characterize the adverse outcomes (AOs) of environmentally relevant exposures, but linking AOs to molecular/cellular mechanisms of toxicity would benefit from the use of readily controllable, simplified host platforms like cell lines. Our objective was to develop and optimize an in vitro-based mitochondrial toxicity assay suite using the honey bee as a model pollinator, and the electron transport chain (ETC) modulators boscalid and pyraclostrobin as model fungicides...
March 15, 2024: Environmental Toxicology and Chemistry
https://read.qxmd.com/read/38488720/investigating-a-novel-neurodegenerative-disease-toxic-mechanism-involving-lipid-binding-specificity-of-amyloid-oligomers
#14
JOURNAL ARTICLE
Sarah S Hirschbeck, Edward T Lindberg, Joshua H Jang, MaKenna R Jacob, Kristi L Lazar Cantrell, Thanh D Do
Exploring the mechanisms underlying the toxicity of amyloid oligomers (AOs) presents a significant opportunity for discovering cures and developing treatments for neurodegenerative diseases. Recently, using a combination of ion mobility spectrometry-mass spectrometry (IMS-MS) and X-ray crystallography (XRC), we showed that the peptide KVKVLWDVIEV, which is the G95W mutant of αB-Crystallin (90-100) and abbreviated as G6W, self-assembles up to a dodecamer that structurally resembles lipid transport proteins...
March 15, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38483349/m6a-rna-methylation-regulates-mitochondrial-function
#15
JOURNAL ARTICLE
Michael Kahl, Zhaofa Xu, Saravanan Arumugam, Brittany Edens, Mariafausta Fischietti, Allen C Zhu, Leonidas C Platanias, Chuan He, Xiaoxi Zhuang, Yongchao C Ma
RNA methylation of N6-methyladenosine (m6A) is emerging as a fundamental regulator of every aspect of RNA biology. RNA methylation directly impacts protein production to achieve quick modulation of dynamic biological processes. However, whether RNA methylation regulates mitochondrial function is not known, especially in neuronal cells which require a high energy supply and quick reactive responses. Here we show that m6A RNA methylation regulates mitochondrial function through promoting nuclear-encoded mitochondrial complex subunit RNA translation...
March 14, 2024: Human Molecular Genetics
https://read.qxmd.com/read/38475718/decoding-hipsc-cm-s-response-to-sars-cov-2-mapping-the-molecular-landscape-of-cardiac-injury
#16
JOURNAL ARTICLE
Sicheng Chen, Zhenquan Fu, Kaitong Chen, Xinyao Zheng, Zhenyang Fu
BACKGROUND: Acute cardiac injury caused by coronavirus disease 2019 (COVID-19) increases mortality. Acute cardiac injury caused by COVID-19 requires understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly infects cardiomyocytes. This study provides a solid foundation for related studies by using a model of SARS-CoV-2 infection in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) at the transcriptome level, highlighting the relevance of this study to related studies...
March 12, 2024: BMC Genomics
https://read.qxmd.com/read/38474356/inhibitors-of-rho-mrtf-srf-transcription-pathway-regulate-mitochondrial-function
#17
JOURNAL ARTICLE
Pankaj Patyal, Xiaomin Zhang, Ambika Verma, Gohar Azhar, Jeanne Y Wei
RhoA-regulated gene transcription by serum response factor (SRF) and its transcriptional cofactor myocardin-related transcription factors (MRTFs) signaling pathway has emerged as a promising therapeutic target for pharmacological intervention in multiple diseases. Altered mitochondrial metabolism is one of the major hallmarks of cancer, therefore, this upregulation is a vulnerability that can be targeted with Rho/MRTF/SRF inhibitors. Recent advances identified a novel series of oxadiazole-thioether compounds that disrupt the SRF transcription, however, the direct molecular target of these compounds is unclear...
February 24, 2024: Cells
https://read.qxmd.com/read/38474253/oxidative-stress-and-cerebral-vascular-tone-the-role-of-reactive-oxygen-and-nitrogen-species
#18
REVIEW
Michele Salvagno, Elda Diletta Sterchele, Mario Zaccarelli, Simona Mrakic-Sposta, Ian James Welsby, Costantino Balestra, Fabio Silvio Taccone
The brain's unique characteristics make it exceptionally susceptible to oxidative stress, which arises from an imbalance between reactive oxygen species (ROS) production, reactive nitrogen species (RNS) production, and antioxidant defense mechanisms. This review explores the factors contributing to the brain's vascular tone's vulnerability in the presence of oxidative damage, which can be of clinical interest in critically ill patients or those presenting acute brain injuries. The brain's high metabolic rate and inefficient electron transport chain in mitochondria lead to significant ROS generation...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474127/applying-proteomics-and-computational-approaches-to-identify-novel-targets-in-blast-associated-post-traumatic-epilepsy
#19
JOURNAL ARTICLE
Jack L Browning, Kelsey A Wilson, Oleksii Shandra, Xiaoran Wei, Dzenis Mahmutovic, Biswajit Maharathi, Stefanie Robel, Pamela J VandeVord, Michelle L Olsen
Traumatic brain injury (TBI) can lead to post-traumatic epilepsy (PTE). Blast TBI (bTBI) found in Veterans presents with several complications, including cognitive and behavioral disturbances and PTE; however, the underlying mechanisms that drive the long-term sequelae are not well understood. Using an unbiased proteomics approach in a mouse model of repeated bTBI (rbTBI), this study addresses this gap in the knowledge. After rbTBI, mice were monitored using continuous, uninterrupted video-EEG for up to four months...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473911/mitochondrial-dysfunction-in-heart-failure-from-pathophysiological-mechanisms-to-therapeutic-opportunities
#20
REVIEW
Giovanna Gallo, Speranza Rubattu, Massimo Volpe
Mitochondrial dysfunction, a feature of heart failure, leads to a progressive decline in bioenergetic reserve capacity, consisting in a shift of energy production from mitochondrial fatty acid oxidation to glycolytic pathways. This adaptive process of cardiomyocytes does not represent an effective strategy to increase the energy supply and to restore the energy homeostasis in heart failure, thus contributing to a vicious circle and to disease progression. The increased oxidative stress causes cardiomyocyte apoptosis, dysregulation of calcium homeostasis, damage of proteins and lipids, leakage of mitochondrial DNA, and inflammatory responses, finally stimulating different signaling pathways which lead to cardiac remodeling and failure...
February 25, 2024: International Journal of Molecular Sciences
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