Yulin Zhang, Kaiyan Xi, Yuying Zhang, Zezheng Fang, Yi Zhang, Kaijie Zhao, Fan Feng, Jianyu Shen, Mingrui Wang, Runlu Zhang, Bo Cheng, Huimin Geng, Xingang Li, Bin Huang, Kang-Nan Wang, Shilei Ni
Glioblastoma multiforme (GBM) is the most aggressive and lethal form of human brain tumors. Dismantling the suppressed immune microenvironment is an effective therapeutic strategy against GBM; however, GBM does not respond to exogenous immunotherapeutic agents due to low immunogenicity. Manipulating the mitochondrial electron transport chain (ETC) elevates the immunogenicity of GBM, rendering previously immune-evasive tumors highly susceptible to immune surveillance, thereby enhancing tumor immune responsiveness and subsequently activating both innate and adaptive immunity...
March 18, 2024: ACS Nano