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Drug-induced enteropathy

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https://www.readbyqxmd.com/read/28554654/nonsteroidal-anti-inflammatory-drug-induced-protein-losing-enteropathy-a-great-masquerade-of-crohn-s-disease
#1
Daniela G Vinsard, Mark E Stark, Jason T Lewis, Ming-Hsi Wang
No abstract text is available yet for this article.
May 26, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28523577/ffa3-activation-stimulates-duodenal-bicarbonate-secretion-and-prevents-nsaid-induced-enteropathy-via-the-glp-2-pathway-in-rats
#2
Hyder Said, Yasutada Akiba, Kazuyuki Narimatsu, Koji Maruta, Ayaka Kuri, Ken-Ichi Iwamoto, Atsukazu Kuwahara, Jonathan D Kaunitz
BACKGROUND: Therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with enteropathy in humans and experimental animals, a cause of considerable morbidity. Unlike foregut NSAID-associated mucosal lesions, most treatments for this condition are of little efficacy. We propose that the endogenously released intestinotrophic hormone glucagon-like peptide-2 (GLP-2) prevents the development of NSAID-induced enteropathy. Since the short-chain fatty acid receptor FFA3 is expressed on enteroendocrine L cells and on enteric nerves in the gastrointestinal tract, we further hypothesized that activation of FFA3 on L cells protects the mucosa from injury via GLP-2 release with enhanced duodenal HCO3(-) secretion...
May 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28510689/chronic-enteropathy-associated-with-slco2a1-gene-ceas-characterization-of-an-enteric-disorder-to-be-considered-in-the-differential-diagnosis-of-crohn-s-disease
#3
Naoki Hosoe, Naoki Ohmiya, Fumihito Hirai, Junji Umeno, Motohiro Esaki, Hirokazu Yamagami, Kei Onodera, Shigeki Bamba, Hiroyuki Imaeda, Shunichi Yanai, Tadakazu Hisamatsu, Haruhiko Ogata, Takayuki Matsumoto
Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal anti-inflammatory drugs (NSAIDs), infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine (CNSU). CNSU is characterized by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 (SLCO2A1) gene, encoding a prostaglandin transporter, were identified by whole-exam sequencing in patients with CNSU...
May 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28437842/autoimmune-like-chronic-hepatitis-induced-by-olmesartan
#4
Sandrine Barge, Marianne Ziol, Jean-Charles Nault
Drug liver-induced injury (DILI) due to minocyclin, alpha methyldopa or nitrofurantoin may be responsible for chronic liver damage that mimic the biological and/or histological features of chronic autoimmune hepatitis and, in rare cases, progresses to cirrhosis(1). Olmesartan medoxomil is an antihypertensive drug that acts by blocking the angiotensin II receptor and is metabolized into its pharmacologically active form, olmesartan, in the intestine and in the liver before being released into the systemic circulation...
April 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28295549/uric-acid-ameliorates-indomethacin-induced-enteropathy-in-mice-through-its-antioxidant-activity
#5
Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari
BACKGROUND AND AIM: Uric acid is excreted from blood into the intestinal lumen, yet the roles of uric acid in intestinal diseases remain to be elucidated. In this study, we aimed to determine whether uric acid could reduce endpoints associated with nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy. METHODS: A mouse model of NSAID-induced enteropathy was generated by administering indomethacin intraperitoneally to 8-week-old male C57BL/6 mice, and then vehicle or uric acid was administered orally...
March 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28291561/olmesartan-associated-sprue-like-enteropathy-an-emerging-cause-of-drug-induced-chronic-diarrhea
#6
G Solano-Iturri, N García-Jiménez, J D Solano-Iturri, S Blanco-Sampascual
No abstract text is available yet for this article.
March 10, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28289500/olmesartan-induced-enteropathy
#7
Abimbola Adike, Juan Corral, David Rybnicek, Daniel Sussman, Samir Shah, Eamonn Quigley
Olmesartan-induced enteropathy mimics celiac disease clinically and pathologically. As in celiac disease, the pathologic findings are villous atrophy and increased intraepithelial lymphocytes. Clinical presentation of olmesartan-induced enteropathy includes diarrhea, weight loss, and nausea. In contrast to celiac disease, tissue transglutaminase is not elevated and there is no response to a gluten-free diet. Including this entity in the differential diagnosis of sprue-like enteropathy is critical for its early diagnosis since replacing olmesartan with an alternative antihypertensive drug can simplify the diagnostic workup and provide both clinical and histologic improvement...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28067296/gut-microbiota-mediates-protection-against-enteropathy-induced-by-indomethacin
#8
Xue Xiao, Geicho Nakatsu, Ye Jin, Sunny Wong, Jun Yu, James Y W Lau
Non-steroidal anti-inflammatory drugs (NSAIDs) can cause significant small bowel injuries. The role of gut microbiota in this NSAID-induced enteropathy is poorly understood. We studied the dynamic changes in gut microbiota following indomethacin administration in mice, and investigated the effects of these adaptive changes on subsequent NSAID-induced enteropathy. The changes in gut microbiota were studied using 16S rRNA sequencing, and the effects of such changes were investigated using antibiotics and a faecal transplantation model...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27998630/nonsteroidal-anti-inflammatory-drugs-induced-small-bowel-enteropathy-and-obscure-gastrointestinal-bleeding
#9
Enrique Pérez-Cuadrado-Robles, Noé Quesada-Vázquez, Blanca Martínez-Andrés, José Francisco Sánchez-Melgarejo, José María Rubio-Mateos, Antonio López-Higueras, Enrique Pérez-Cuadrado-Martínez
No abstract text is available yet for this article.
December 17, 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27824272/in-vivo-effects-of-s-pantoprazole-polaprenzinc-and-probiotic-blend-on-chronic-small-intestinal-injury-induced-by-indomethacin
#10
S J Byun, T J Lim, Y J Lim, J G Seo, M J Chung
Treatment and prevention methods for non-steroidal anti-inflammatory drug-induced enteropathy have not yet been established. We tested the preventive effects of s-pantoprazole sodium trihydrate (PAN), polaprezinc (PZ), and probiotics on an indomethacin (Indo)-induced small intestinal injury in a rat model. Rats were randomised into 6 groups to receive: normal saline (control), Indo (6 mg/kg), PZ plus Indo, PAN plus Indo, or probiotics plus Indo (at 10(8) and 10(9) cfu/head) for 2 weeks. We measured body weight, food intake, severity of small intestinal damage, haemoglobin (Hb) levels in the small intestinal fluid, intestinal inflammatory cytokines, and a few groups of faecal bacteria...
November 30, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27803820/seronegative-intestinal-villous-atrophy-a-diagnostic-challenge
#11
Cláudio Martins, Cristina Teixeira, Suzane Ribeiro, Daniel Trabulo, Cláudia Cardoso, João Mangualde, Ricardo Freire, Ana Luísa Alves, Élia Gamito, Isabelle Cremers, Ana Paula Oliveira
Celiac disease is the most important cause of intestinal villous atrophy. Seronegative intestinal villous atrophy, including those that are nonresponsive to a gluten-free diet, is a diagnostic challenge. In these cases, before establishing the diagnosis of seronegative celiac disease, alternative etiologies of atrophic enteropathy should be considered. Recently, a new clinical entity responsible for seronegative villous atrophy was described-olmesartan-induced sprue-like enteropathy. Herein, we report two uncommon cases of atrophic enteropathy in patients with arterial hypertension under olmesartan, who presented with severe chronic diarrhea and significant involuntary weight loss...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27771494/drug-induced-mitochondrial-dysfunction-mechanisms-and-adverse-clinical-consequences
#12
REVIEW
Madhusudanarao Vuda, Ashwin Kamath
Several commonly used medications impair mitochondrial function resulting in adverse effects or toxicities. Drug induced mitochondrial dysfunction may be a consequence of increased production of reactive oxygen species, altered mitochondrial permeability transition, impaired mitochondrial respiration, mitochondrial DNA damage or inhibition of beta-oxidation of fatty acids. The clinical manifestation depends on the specific drug and its effect on mitochondria. Given the ubiquitous presence of mitochondria and its central role in cellular metabolism, drug-mitochondrial interactions may manifest clinically as hepatotoxicity, enteropathy, myelosuppression, lipodystrophy syndrome or neuropsychiatric adverse effects, to name a few...
November 2016: Mitochondrion
https://www.readbyqxmd.com/read/27621502/ranolazine-induced-reversible-t-wave-inversions-with-prolonged-qtc-interval-progressive-multifocal-leukoencephalopathy-linked-to-fingolimod-losartan-induced-sprue-like-enteropathy-nivolumab-induced-psoriasiform-skin-eruption-hepatitis-b-reactivation-with-hepatitis
#13
EDITORIAL
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MED WATCH program (800-FDA-1088). If you have reported an interesting, preventable ADR to MED WATCH, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
November 2015: Hospital Pharmacy
https://www.readbyqxmd.com/read/27578916/cox-2-inhibitory-nsaid-induced-multiple-stenosis-in-the-small-intestine-diagnosed-by-double-balloon-endoscopy
#14
Yasuaki Ueno, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Hidemi Goto, Yoshiki Hirooka
The patient was a 72 year old man who had been given non-steroidal anti-inflammatory drug (NSAID) for two years. He repeatedly developed small intestinal ileus; therefore, he underwent several imaging examinations, but the cause was not identified. He subsequently underwent a double-balloon endoscopy (DBE). The membranous stenoses were detected in the jejunum, and the biopsy specimens were taken during the DBE. The membranous stenoses in the gastrointestinal tract were characteristic of NSAID-induced enteropathy, and he was endoscopically and histopathologically diagnosed with NSAID-induced small intestinal disorder...
August 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27549792/small-intestinal-injury-in-nsaid-users-suffering-from-rheumatoid-arthritis-or-osteoarthritis
#15
Ilja Tachecí, Petr Bradna, Tomáš Douda, Drahomíra Baštecká, Marcela Kopáčová, Stanislav Rejchrt, Martin Lutonský, Tomáš Soukup, Jan Bureš
The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A total of 143 patients (74 with RA, 69 with OA) treated with NSAIDs (>1 month) and 42 healthy volunteers were included. All subjects underwent capsule endoscopy, laboratory tests and filled in questionnaires. The severity of small bowel injury was graded as: mild (red spots or sporadic erosions), moderate (10-20 erosions) or severe (>20 erosions or ulcers)...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27467110/pediatric-onset-chronic-nonspecific-multiple-ulcers-of-small-intestine-a-nationwide-survey-and-genetic-study-in-japan
#16
Keiichi Uchida, Atsushi Nakajima, Kosuke Ushijima, Shinobu Ida, Yoshitaka Seki, Fumihiko Kakuta, Daiki Abukawa, Hisayuki Tsukahara, Shun-Ichi Maisawa, Mikihiro Inoue, Toshimitsu Araki, Junji Umeno, Takayuki Matsumoto, Tomoaki Taguchi
We performed a Japanese nationwide survey of pediatric-onset chronic nonspecific multiple ulcers of the small intestine between January 2000 and July 2013 in 176 institutions of pediatric surgery or pediatric gastroenterology and clarified the clinical features associated with genetic abnormalities in the Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) gene. A total of 4 cases (3 girls and 1 boy) were diagnosed in this series, which had to be differentiated from Crohn disease, Behçet disease, tuberculosis, or drug-induced enteropathy...
April 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27446843/adding-water-to-the-mill-olmesartan-induced-collagenous-sprue-a-case-report-and-brief-literature-review
#17
REVIEW
Claudine Desruisseaux, Michaël Bensoussan, Etienne Désilets, Hanh-Khiem Tran, Robert Arcand, Germain Poirier, Andrew Wisniewski, Thibaut Manière
Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al. in 2012. CS is historically associated with a poor prognosis (Marthey et al., 2014). However, histological and clinical improvements have been described in most studies with concomitant usage of corticosteroids and/or gluten-free diet (Marthey et al...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27415620/uncontrolled-il-17-production-by-intraepithelial-lymphocytes-in-a-case-of-non-ipex-autoimmune-enteropathy
#18
Moira Paroni, Andrea Magarotto, Silvia Tartari, Giulia Nizzoli, Paola Larghi, Giulia Ercoli, Umberto Gianelli, Massimiliano Pagani, Luca Elli, Sergio Abrignani, Dario Conte, Jens Geginat, Flavio Caprioli
OBJECTIVES: To provide a functional and phenotypic characterization of immune cells infiltrating small intestinal mucosa during non-IPEX autoimmune enteropathy (AIE), as to gain insights on the pathogenesis of this clinical condition. METHODS: Duodenal biopsies from a patient with AIE at baseline and following drug-induced remission were analyzed by immunohistochemistry, immunofluorescence, and flow cytometry, and results were compared with those obtained from patients with active celiac disease, ileal Crohn's disease and healthy controls...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27371837/-the-preventive-effect-of-total-saponins-of-panax-japonicus-on-nonsteroidal-anti-inflammatory-drug-induced-enteropathy
#19
Ying Mei, Zhaozhao Xiao, Jinwu Feng, Ting Wang, Changcheng Zhang, Ding Yuan, Chaoqi Liu
Objective To investigate the preventive effect of total saponins of Panax japonicus (SPJ) on nonsteroidal anti-inflammatory drug (NSAID)-induced intestinal injuries in mice. Methods NSAID-induced intestinal mucosal damaged models were established by intragastric administration of 5 mg/mL diclofenac sodium in mice for continuous 2 days. Since 4 days before the modeling, the mice in the experimental group were given SPJ once a day for 6 days. The small intestinal mucosal permeability was detected by fluorescein isothiocyanate-dextran (FITC-DT) and Evans blue staining...
June 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27180979/ciprofloxacin-blocked-enterohepatic-circulation-of-diclofenac-and-alleviated-nsaid-induced-enteropathy-in-rats-partly-by-inhibiting-intestinal-%C3%AE-glucuronidase-activity
#20
Ze-Yu Zhong, Bin-Bin Sun, Nan Shu, Qiu-Shi Xie, Xian-Ge Tang, Zhao-Li Ling, Fan Wang, Kai-Jing Zhao, Ping Xu, Mian Zhang, Ying Li, Yang Chen, Li Liu, Lun-Zhu Xia, Xiao-Dong Liu
AIM: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy). In this study we investigated whether co-administration of ciprofloxacin affected the pharmacokinetics of diclofenac and diclofenac-induced enteropathy in rats. METHODS: The pharmacokinetics of diclofenac was assessed in rats after receiving diclofenac (10 mg/kg, ig, or 5 mg/kg, iv), with or without ciprofloxacin (20 mg/kg, ig) co-administered...
July 2016: Acta Pharmacologica Sinica
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