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https://www.readbyqxmd.com/read/29655836/incidence-of-hepatocellular-carcinoma-in-patients-with-hcv-associated-cirrhosis-treated-with-direct-acting-antiviral-agents
#1
Vincenza Calvaruso, Giuseppe Cabibbo, Irene Cacciola, Salvatore Petta, Salvatore Madonia, Alessandro Bellia, Fabio Tinè, Marco Distefano, Anna Licata, Lydia Giannitrapani, Tullio Prestileo, Giovanni Mazzola, Maria Antonietta Di Rosolini, Licia Larocca, Gaetano Bertino, Antonio Digiacomo, Francesco Benanti, Luigi Guarneri, Alfonso Averna, Carmelo Iacobello, Antonio Magro, Ignazio Scalisi, Fabio Cartabellotta, Francesca Savalli, Marco Barbara, Antonio Davì, Maurizio Russello, Gaetano Scifo, Giovanni Squadrito, Calogero Cammà, Giovanni Raimondo, Antonio Craxì, Vito Di Marco
BACKGROUND & AIMS: Studies have produced conflicting results of the incidence of hepatocellular carcinoma (HCC) in patients with in hepatitis C virus (HCV)-associated cirrhosis treated with direct-acting antivirals (DAAs). Data from clinics are needed to accurately assess the occurrence rate of HCC in patients with cirrhosis in the real world. METHODS: We collected data from a large prospective study of 2249 consecutive patients (mean age, 65.4 years and 56...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29648413/joint-consensus-on-abdominal-robotic-surgery-and-anaesthesia-from-a-task-force-of-the-siaarti-and-sic
#2
Antonio Corcione, Pierluigi Angelini, Lapo Bencini, Elisabetta Bertellini, Felice Borghi, Claudio Buccelli, Giuseppe Coletta, Clelia Esposito, Vincenzo Graziano, Fabio Guarracino, Domenico Marchi, Pasquale Misitano, Anna M Mori, Mariano Paternoster, Vincenzo Pennestrì, Vittorio Perrone, Luigi Pugliese, Stefano Romagnoli, Luigia Scudeller, Francesco Corcione
BACKGROUND: Minimally invasive surgical procedures have revolutionized the world of surgery in the past decades. While laparoscopy, the first minimally invasive surgical technique to be developed, is widely used and has been addressed by several guidelines and recommendations, the implementation of robotic-assisted surgery is still hindered by the lack of consensus documents that support healthcare professionals in the management of this novel surgical procedure. Here we summarize the available evidence and provide expert opinion aimed at improving the implementation and resolution of issues derived from robotic abdominal surgery procedures...
April 12, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29493635/-rischio-di-non-persistenza-e-utilizzo-delle-risorse-sanitarie-in-pazienti-italiani-con-fibrillazione-atriale-non-valvolare
#3
Nazarena Cataldo, Valeria Pegoraro, Claudio Ripellino, Valentino Bertasi, Roberta Di Turi, Maurizio Pastorello, Marco Gambera
Riassunto. Il presente studio intende confrontare il rischio di non persistenza e l'utilizzo delle risorse sanitarie nei pazienti con fibrillazione atriale non valvolare (FANV) naïve al trattamento con antagonisti della vitamina K (AVK) o con nuovi anticoagulanti orali (NAO). Partendo dai database amministrativi di cinque ASL italiane, sono stati selezionati e inclusi nello studio tutti i pazienti con almeno una dimissione ospedaliera per FANV dal 2011 al 2014. Tra questi, i nuovi utilizzatori di AVK o NAO nel 2014 sono stati identificati e seguiti a partire dalla data della prima prescrizione al verificarsi di uno qualsiasi dei seguenti eventi: interruzione della terapia superiore a 90 giorni, passaggio o aggiunta di una molecola differente rispetto a quella prescritta alla data indice, morte del paziente, fine del follow-up (dicembre 2015)...
February 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29493397/ceftolozane-tazobactam-place-in-therapy
#4
Daniele Roberto Giacobbe, Matteo Bassetti, Francesco Giuseppe De Rosa, Valerio Del Bono, Paolo Antonio Grossi, Francesco Menichetti, Federico Pea, Gian Maria Rossolini, Mario Tumbarello, Pierluigi Viale, Claudio Viscoli
Ceftolozane/tazobactam (C/T) is a new antibiotic resulting from the combination of a novel cephalosporin, structurally similar to ceftazidime, with tazobactam, a well-known beta-lactamase inhibitor. C/T remains active against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and multi-drug resistant (MDR) P. aeruginosa, and has been recently approved for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI). A trial on hospital-acquired pneumonia is ongoing...
March 9, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29469793/lesiones-subcut%C3%A3-neas-dolorosas-en-paciente-con-melanoma-metast%C3%A3-sico-un-caso-de-paniculitis-linfoc%C3%A3-tica-asociado-a-vemurafenib
#5
Felipe Benavente-Villegas, Francisco Ferrando-Roca, Raquel Dolz-Gaitón, María Royo-Peiró
Vemurafenib ha probado ser una herramienta útil en el tratamiento de melanoma metastásico con mutación BRAF-V600E. Los efectos adversos incluyen artralgias, fatiga y toxicidad cutánea, siendo infrecuente la paniculitis. Presentamos el caso de una paciente de 43 años con melanoma metastásico que desarrolla lesiones subcutáneas dolorosas en miembros inferiores y superiores, asociadas a clínica sistémica después de 2 semanas de inicio de tratamiento con Vemurafenib + Cobimetinib. La histología demostró paniculitis linfocitaria septal y lobulillar...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469785/p%C3%A3-nfigo-foli%C3%A3-ceo-agravado-por-f%C3%A3-rmacos-en-un-paciente-con-psoriasis-con-buena-respuesta-a-adalimumab
#6
Jimena Sanz-Bueno, Elena Gallo, Dolores Caro-Gutiérrez, Araceli Sánchez-Gilo, Marta Gutiérrez Pascual, Laura Rojas-Scheffer, Francisco Javier Vicente-Martín
El pénfigo foliáceo es una enfermedad autoinmune ampollosa debida a la producción de autoanticuerpos frente a la desmogleína 1. Presentamos el caso de un paciente con psoriasis y pénfigo foliáceo agravado por enalapril y amlodipino, con buena respuesta de ambas patologías a la terapia con adalimumab.Pemphigus foliaceus is a blistering autoimmune disease related to the production of autoantibodies against desmoglein 1. We present a patient with psoriasis and pemphigus foliaceus aggravated by enalapril and amlodipine intake, with successful response of both conditions to adalimumab therapy...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29297902/-la-combinazione-di-gemcitabina-e-oxaliplatino-gemox-nel-trattamento-del-carcinoma-pancreatico-in-fase-avanzata-di-malattia-le-notizie-sulla-mia-morte-sono-state-esagerate
#7
Jacopo Giuliani, Andrea Bonetti
Riassunto. L'analisi è stata condotta al fine di valutare l'effetto sia sulla sopravvivenza globale (OS) sia sulla sopravvivenza libera da progressione di malattia (PFS) della chemioterapia di combinazione in prima linea per il carcinoma pancreatico in fase avanzata di malattia. La presente analisi è limitata agli studi randomizzati controllati (RCT) di fase III. Successivamente è stata applicata la European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) agli RCT di fase III analizzati per ricavare uno score relativo all'entità del beneficio clinico ottenuto per ciascun RCT...
December 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29122291/respiratory-support-therapy-after-extubation-who-and-how
#8
G Hernandez, O Roca
No abstract text is available yet for this article.
November 6, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29105699/-fisiopatologia-dei-comportamenti-aggressivi-in-salute-mentale
#9
Enrico Pompili, Cristiano Carlone, Cristiana Silvestrini, Giuseppe Nicolò
RIASSUNTO. Introduzione. L'aggressività è un comportamento con origini evolutive, ma nella società di oggi è spesso distruttivo e disadattivo. Un aumento del comportamento aggressivo è presente in molte malattie mentali e rappresenta una sfida clinica per il servizio sanitario. Questi fenomeni possono portare ad agiti dannosi e violenti, rappresentando una grave preoccupazione per la salute pubblica. L'aggressività è spesso motivo di ospedalizzazione psichiatrica, e può portare a soggiorni ospedalieri prolungati, sofferenze dei pazienti e delle loro vittime con aumento della stigmatizzazione...
September 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29044359/management-della-retinopatia-diabetica-e-dell-edema-maculare-diabetico-linee-guida-euretina-2017
#10
P Turchetti, A Librando, F Angelucci, S C Carlesimo, R Migliorini
Si prevede che la malattia diabetica con tutte le sue complicanze avrà un forte aumento di incidenza con un grosso impatto socioeconomico nei prossimi decenni in tutto il mondo. Pertanto ben si comprende l'importanza di individuare attraverso una fine diagnostica quanto più precocemente la comparsa dei sintomi diabetici, migliorare lo stile di vita ed impostare cure efficienti. Riportiamo la serie di raccomandazioni EURETINA 2017, dei maggiori esperti in Europa per la gestione della malattia diabetica e delle complicanze della retina...
September 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28991291/catastrophic-antiphospholipid-syndrome-case-report-and-literature-review
#11
REVIEW
Luis del Carpio-Orantes, Chantall Citlally Martínez-Anaya, Elías Bonilla-Casas
The present document is the report of a case of a very rare clinical entity, which presents with acute multiorganic failure after a thrombotic storm related to antiphospholipid antibodies, the so-called catastrophic antiphospholipid syndrome, which began as a recurrent picture of mesenteric thrombosis, with a previous history of venous insufficiency and distal ulcers probably associated with an unidentified antiphospholipid; deserving management in intensive care and the consultation by the world expert, Dr...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28977232/humanization-in-the-intensive-care-perception-of-family-and-healthcare-professionals
#12
Flavia Feron Luiz, Rita Catalina Aquino Caregnato, Márcia Rosa da Costa
Objective: Understanding perceptions of family members and healthcare professionals about humanization at the Intensive Care Unit (ICU) to direct it to an educational action. Method: Exploratory descriptive and qualitative study conducted in an ICU level 3 of a public hospital in Porto Alegre, RS, Brazil, with fourteen subjects, eight family members and six healthcare professionals. Data collection carried out through semi-structured interviews and focus group. Content Analysis was used...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28977229/critical-incidents-connected-to-nurses-leadership-in-intensive-care-units
#13
Elaine Cantarella Lima, Andrea Bernardes, Priscila Lapaz Baldo, Vanessa Gomes Maziero, Silvia Helena Henriques Camelo, Alexandre Pazetto Balsanelli
Objective: The goal of this study is to analyze nurses' leadership in intensive care units at hospitals in the state of São Paulo, Brazil, in the face of positive and negative critical incidents. Method: Exploratory, descriptive study, conducted with 24 nurses by using the Critical Incident Technique as a methodological benchmark. Results: Results were grouped into 61 critical incidents distributed into categories. Researchers came to the conclusion that leadership-related situations interfere with IC nurses' behaviors...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28977219/severity-and-workload-related-to-adverse-events-in-the-icu
#14
Clarita Terra Rodrigues Serafim, Magda Cristina Queiroz Dell'Acqua, Meire Cristina Novelli E Castro, Wilza Carla Spiri, Hélio Rubens de Carvalho Nunes
Objective: To analyze whether an increase in patient severity and nursing workload are correlated to a greater incidence of adverse events (AEs) in critical patients. Method: A prospective single cohort study was performed on a sample of 138 patients hospitalized in an intensive care unit (ICU). Results: A total of 166 AEs, occurred, affecting 50.7% of the patients. Increased patient severity presented a direct relationship to the probability of AEs occurring...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28954035/preimplantation-genetic-diagnosis-associated-to-duchenne-muscular-dystrophy
#15
Bianca Bianco, Denise Maria Christofolini, Gabriel Seixas Conceição, Caio Parente Barbosa
Duchenne muscular dystrophy is the most common muscle disease found in male children. Currently, there is no effective therapy available for Duchenne muscular dystrophy patients. Therefore, it is essential to make a prenatal diagnosis and provide genetic counseling to reduce the birth of such boys. We report a case of preimplantation genetic diagnosis associated with Duchenne muscular dystrophy. The couple E.P.R., 38-year-old, symptomatic patient heterozygous for a 2 to 47 exon deletion mutation in DMD gene and G...
September 21, 2017: Einstein
https://www.readbyqxmd.com/read/28902934/assessment-and-management-of-pain-in-newborns-hospitalized-in-a-neonatal-intensive-care-unit-a-cross-sectional-study
#16
Natália Pinheiro Braga Sposito, Lisabelle Mariano Rossato, Mariana Bueno, Amélia Fumiko Kimura, Taine Costa, Danila Maria Batista Guedes
Objective: to determine the frequency of pain, to verify the measures adopted for pain relief during the first seven days of hospitalization in the Neonatal Intensive Care Unit and to identify the type and frequency of invasive procedures to which newborns are submitted. Method: cross-sectional retrospective study. Out of the 188 hospitalizations occurred during the 12-month period, 171 were included in the study. The data were collected from the charts and the presence of pain was analyzed based on the Neonatal Infant Pain Scale and on nursing notes suggestions of pain...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28902933/prototype-of-a-computerized-scale-for-the-active-search-for-potential-organ-donors
#17
Érika Fernanda Dos Santos Bezerra Ludwig, Marta Cristiane Alves Pereira, Yolanda Dora Évora Martinez, Karina Dal Sasso Mendes, Mariana Angela Rossaneis
Objective: to develop a prototype of a computerized scale for the active search for potential organ and tissue donors. Method: methodological study, with the analysis of 377 electronic medical records of patients who died due to encephalic death or cardiorespiratory arrest in the intensive care units of a tertiary hospital. Among the deaths due to cardiorespiratory arrest, the study aimed to identify factors indicating underreported encephalic death cases. The Acute Physiology and Chronic Health Evaluation II and Sepsis Related Organ Failure Assessment severity indexes were applied in the protocols...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28902326/microstructural-evaluation-by-confocal-and-electron-microscopy-in-thrombi-developed-in-central-venous-catheters
#18
Thabata Coaglio Lucas, Eliata Ester da Silva, Danilo Olzon Dionysio Souza, Amanda Rodrigues Dos Santos, Maristela Oliveira Lara
OBJECTIVE: Evaluating thrombi microstructure developed in central venous catheters using confocal and electron microscopy. METHOD: An experimental, descriptive study carrying out a microstructural evaluation of venous thrombi developed in central venous catheters using Scanning Electron Microscopy and Confocal Laser Scanning Microscopy. RESULTS: A total of 78 venous catheters were collected over a period of three months. Different fibrin structures were distinguished: fibrin plates, fibrin network, and fibrin fibers...
August 28, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28842283/effect-of-combination-therapy-containing-a-high-dose-carbapenem-on-mortality-in-patients-with-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infection
#19
Maddalena Giannella, Enrico Maria Trecarichi, Daniele Roberto Giacobbe, Francesco Giuseppe De, Matteo Bassetti, Alessandro Bartoloni, Michele Bartoletti, Angela Raffaella Losito, Valerio Del Bono, Silvia Corcione, Sara Tedeschi, Francesca Raffaelli, Carolina Saffioti, Teresa Spanu, Gian Maria Rossolini, Anna Marchese, Simone Ambretti, Roberto Cauda, Claudio Viscoli, Russell Edward Lewis, Pierluigi Viale, Mario Tumbarello
OBJECTIVES: To evaluate the impact of high-dose (HD) carbapenem-based combination therapy on clinical outcome in patients with monomicrobial carbapenem-resistant Klebsiella pneumoniae (CR-KP) bloodstream-infection (BSI). METHODS: Post hoc analysis of all adult patients with CR-KP BSI who were treated with combination antibiotic regimen, collected over 6-year period in 6 large teaching Italian hospitals. To control for confounding effects of HD carbapenem combination on 14-day mortality, a multivariate Cox regression analysis was performed...
August 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28793102/deaths-among-the-elderly-with-icu-infections
#20
Álvaro Francisco Lopes de Sousa, Artur Acelino Francisco Luz Nunes Queiroz, Layze Braz de Oliveira, Luana Kelle Batista Moura, Denise de Andrade, Evandro Watanabe, Maria Eliete Batista Moura
Objective: to evaluate the clinical outcome of elderly patients admitted to intensive care units who had nosocomial infection, correlating the findings with sociodemographic and clinical variables. Method: descriptive research, performed with 308 elderly patients. The collection was made from medical records and covers the years 2012 to 2015. Uni-/bivariate analyses were performed. Results: a statistical association was found between the clinical outcome types and the variables age, length of stay, presence of previous comorbidities, main diagnosis, respiratory and urinary tract infections, use of central venous and indwelling urinary catheters, mechanical ventilation, and tracheostomy...
July 2017: Revista Brasileira de Enfermagem
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