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https://www.readbyqxmd.com/read/29659839/airway-glycomic-and-allergic-inflammatory-consequences-resulting-from-keratan-sulfate-galactose-6-o-sulfotransferase-chst1-deficiency
#1
Tadahiro Kumagai, Takumi Kiwamoto, Mary E Brummet, Fan Wu, Kazuhiro Aoki, Zhou Zhu, Bruce S Bochner, Michael Tiemeyer
Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6'-sulfated sialyl Lewis X and 6'-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays. We hypothesized that attenuation of the carbohydrate sulfotransferase 1 (CHST1) gene encoding keratan sulfate galactose 6-O-sulfotransferase, an enzyme likely required for 6'-sulfation of some of these putative Siglec-F glycan ligands, would result in decreased Siglec-F lung ligand levels and enhanced allergic eosinophilic airway inflammation...
April 6, 2018: Glycobiology
https://www.readbyqxmd.com/read/29645346/identification-of-a-siglec-f-granulocyte-macrophage-progenitor
#2
Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax
In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloid progenitors and granulocyte-macrophage progenitors), to terminally differentiated mature cells. Myeloid progenitors are heterogeneous, and the surface markers that define transition states from progenitors to mature cells are poorly characterized. Siglec-F is a surface glycoprotein frequently used in combination with IL-5 receptor alpha (IL5Rα) for the identification of murine eosinophils...
April 12, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29618635/removal-of-sialic-acid-from-bull-sperm-decreases-motility-and-mucus-penetration-ability-but-increases-zona-pellucida-binding-and-polyspermic-penetration-in-vitro
#3
Beatriz Fernandez-Fuertes, Alfonso Blanco-Fernandez, Colm J Reid, Kieran Meade, S Fair, Pat Lonergan
This study tested the hypothesis that sperm sialic acid (Sia) is required to reach the site of fertilization, and that successful fertilization requires recognition of Sia from both the sperm and oocyte to occur. In addition, it has recently been reported that Siglecs (Sia-binding-immunoglobulin-like lectins) are present on the sperm surface. Thus, the possibility that the recognition of oocyte Sia was sperm-Siglec-mediated was also addressed. Sperm exposed to neuraminidase (NMase) exhibited lower overall and progressive motility, which translated to a decreased ability to swim through cervical mucus from cows in oestrus...
April 4, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29617289/a-developed-nk-92mi-cell-line-with-siglec-7-neg-phenotype-exhibits-high-and-sustainable-cytotoxicity-against-leukemia-cells
#4
Chin-Han Huang, Yi-Jen Liao, Ting-Hsi Fan, Tzeon-Jye Chiou, Yen-Hsi Lin, Yuh-Ching Twu
Altered sialic acid processing that leads to upregulation of cell surface sialylation is recognized as a key change in malignant tissue glycosylation. This cancer-associated hypersialylation directly impacts the signaling interactions between tumor cells and their surrounding microenvironment, especially the interactions mediated by immune cell surface sialic acid-binding immunoglobulin-like lectins (Siglecs) to relay inhibitory signals for cytotoxicity. First, we obtained a Siglec-7neg NK-92MI cell line, NK-92MI-S7N, by separating a group of Siglec-7neg cell population from an eight-month-long-term NK-92MI in vitro culture by fluorescence-activated cell sorting (FACS)...
April 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29616021/adaptive-reconfiguration-of-natural-killer-cells-in-hiv-1-infection
#5
Dimitra Peppa, Isabela Pedroza-Pacheco, Pierre Pellegrino, Ian Williams, Mala K Maini, Persephone Borrow
Human cytomegalovirus (HCMV) co-infection is highly prevalent within HIV-1 cohorts and is an important cofactor in driving ongoing immune activation, even during effective antiretroviral treatment. HCMV infection has recently been associated with expansion of adaptive-like natural killer (NK) cells, which harbor epigenetic alterations that impact on their cellular function and phenotype. The influence of HCMV co-infection on the considerable heterogeneity among NK cells and their functional responses to different stimuli was assessed in a cohort of HIV-1-infected individuals sampled during different stages of infection, compared with healthy subjects stratified according to HCMV serostatus...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29601103/characterization-of-a-novel-mouse-strain-expressing-human-siglec-8-only-on-eosinophils
#6
Jeremy A O'Sullivan, Yadong Wei, Daniela J Carroll, Liliana Moreno-Vinasco, Yun Cao, Fengrui Zhang, James J Lee, Zhou Zhu, Bruce S Bochner
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a human cell surface protein expressed exclusively on eosinophils, mast cells, and basophils that, when engaged, induces eosinophil apoptosis and inhibits mast cell mediator release. This makes Siglec-8 a promising therapeutic target to treat diseases involving these cell types. However, preclinical studies of Siglec-8 targeting in vivo are lacking because this protein is only found in humans, apes, and some monkeys. Therefore, we have developed a mouse strain in which SIGLEC8 transcription is activated by Cre recombinase and have crossed this mouse with the eoCre mouse to achieve eosinophil-specific expression...
March 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29594046/a-cartography-of-siglecs-and-sialyltransferases-in-gynecologic-malignancies-is-there-a-road-towards-a-sweet-future
#7
Quentin Haas, Cedric Simillion, Stephan von Gunten
Altered surface glycosylation is a key feature of cancers, including gynecologic malignancies. Hypersialylation, the overexpression of sialic acid, is known to promote tumor progression and to dampen antitumor responses by mechanisms that also involve sialic acid binding immunoglobulin-like lectins (Siglecs), inhibitory immune receptors. Here, we discuss the expression patterns of Siglecs and sialyltransferases (STs) in gynecologic cancers, including breast, ovarian, and uterine malignancies, based on evidence from The Cancer Genome Atlas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29581386/siglec-expression-on-the-surface-of-human-bull-and-ram-sperm
#8
K Alkhodair, H Almhanna, J McGetrick, S Gedair, M E Gallagher, B Fernandez-Fuertes, T Tharmalingam, P B Larsen, E Fitzpatrick, P Lonergan, A C O Evans, S D Carrington, C J Reid
Sialic acid (Sia) is a major constituent of both the sperm glycocalyx and female reproductive mucosal surface and is involved in regulating sperm migration, uterotubal reservoir formation and oocyte binding. Siglecs (sialic acid-binding immunoglobulin - like lectins) commonly found on immune cells, bind to Sia in a linkage- and sugar-specific manner and often mediate cell-to-cell interactions and signalling. Proteomic and transcriptomic analysis of human and bovine sperm have listed Siglecs, but to date, their presence and/or localisation on sperm has not been studied...
April 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29576316/glycosylation-in-cancer-selected-roles-in-tumour-progression-immune-modulation-and-metastasis
#9
Joana G Rodrigues, Meritxell Balmaña, Joana A Macedo, Juliana Poças, Ângela Fernandes, Julio Cesar M de-Freitas-Junior, Salomé S Pinho, Joana Gomes, Ana Magalhães, Catarina Gomes, Stefan Mereiter, Celso A Reis
Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate multi-step process that requires the acquisition of several cancer cell features, including the modulation of tumour cell migration, adhesion, invasion, and immune evasion. Changes in the cellular glycosylation are associated with malignant transformation of cancer cells, tumour progression and ultimately, metastasis formation. Glycans have major impact on cellular signalling and on the regulation of tumour cell-cell adhesion and cell-matrix interaction...
March 20, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29503442/siglec-genes-confer-resistance-to-systemic-lupus-erythematosus-in-humans-and-mice
#10
Rhonda Flores, Peng Zhang, Wei Wu, Xu Wang, Peiying Ye, Pan Zheng, Yang Liu
A recent meta-analysis revealed the contribution of the SIGLEC6 locus to the risk of developing systemic lupus erythematosus (SLE). However, no specific Siglec (sialic acid-binding immunoglobulin-like lectin) genes (Siglecs) have been implicated in the pathogenesis of SLE. Here, we performed in silico analysis of the function of three major protective alleles in the locus and found that these alleles were expression quantitative trait loci that enhanced expression of the adjacent SIGLEC12 gene. These data suggest that SIGLEC12 may protect against the development of SLE in Asian populations...
March 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29491407/cell-based-glycan-arrays-for-probing-glycan-glycan-binding-protein-interactions
#11
Jennie Grace Briard, Hao Jiang, Kelley W Moremen, Matthew Scott Macauley, Peng Wu
Glycan microarrays provide a high-throughput means of profiling the interactions of glycan-binding proteins with their ligands. However, the construction of current glycan microarray platforms is time consuming and expensive. Here, we report a fast and cost-effective method for the assembly of cell-based glycan arrays to probe glycan-glycan-binding protein interactions directly on the cell surface. Chinese hamster ovary cell mutants with a narrow and relatively homogeneous repertoire of glycoforms serve as the foundation platforms to develop these arrays...
February 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/29484482/new-interplay-between-interstitial-and-alveolar-macrophages-explains-pulmonary-alveolar-proteinosis-pap-induced-by-indium-tin-oxide-particles
#12
François Huaux, Valentin De Gussem, Astrid Lebrun, Yousof Yakoub, Mihaly Palmai-Pallag, Saloua Ibouraadaten, Francine Uwambayinema, Dominique Lison
Occupational exposure to indium tin oxide (ITO) particles has been associated with the development of severe lung diseases, including pulmonary alveolar proteinosis (PAP). The mechanisms of this lung toxicity remain unknown. Here, we reveal the respective roles of resident alveolar (Siglec-Fhigh AM) and recruited interstitial (Siglec-Flow IM) macrophages contributing in concert to the development of PAP. In mice treated with ITO particles, PAP is specifically associated with IL-1α (not GM-CSF) deficiency and Siglec-Fhigh AM (not Siglec-Flow IM) depletion...
April 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29459531/-siglec-f-8
#13
(no author information available yet)
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29427600/the-first-report-of-siglec-3-cd33-gene-in-a-teleost-rock-bream-oplegnathus-fasciatus-an-analysis-of-its-spatial-expression-during-stimulation-to-red-seabream-iridovirus-rsiv-and-two-bacterial-pathogens
#14
Joseph Jeswin, Min-Soo Joo, Ji-Min Jeong, Jin-Sol Bae, Kwang-Min Choi, Dong-Hee Cho, Son-Il Park, Chan-Il Park
Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytoplasmic tail. It has a deduced amino acid sequence of 390 residues and has tyrosine-based signaling motifs in the cytoplasmic tail. The RbCD33 mRNA was highly expressed in peripheral blood leukocytes and was also detected in the muscle, spleen, skin, head kidney, gills, trunk kidney, heart, stomach, brain, intestine and liver by quantitative real-time PCR...
February 7, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29391504/mapping-the-interaction-site-and-effect-of-the-siglec-9-inflammatory-biomarker-on-human-primary-amine-oxidase
#15
Leonor Lopes de Carvalho, Heli Elovaara, Jerôme de Ruyck, Gerard Vergoten, Sirpa Jalkanen, Gabriela Guédez, Tiina A Salminen
Human primary amine oxidase (hAOC3), also known as vascular adhesion protein 1, mediates leukocyte rolling and trafficking to sites of inflammation by a multistep adhesion cascade. hAOC3 is absent on the endothelium of normal tissues and is kept upregulated during inflammatory conditions, which is an applicable advantage for imaging inflammatory diseases. Sialic acid binding immunoglobulin like-lectin 9 (Siglec-9) is a leukocyte ligand for hAOC3. The peptide (CARLSLSWRGLTLCPSK) based on the region of Siglec-9 that interacts with hAOC3, can be used as a specific tracer for hAOC3-targeted imaging of inflammation using Positron Emission Tomography (PET)...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29388006/glycan-recognition-by-human-blood-mononuclear-cells-with-an-emphasis-on-dendritic-cells
#16
Eugenia M Rapoport, Sergey V Khaidukov, Andrey M Gaponov, Galina V Pazynina, Svetlana V Tsygankova, Ivan M Ryzhov, Ivan M Belyanchikov, Panagiota Milona, Nicolai V Bovin, Kenneth C McCullough
Dendritic cells (DCs) play crucial roles in innate and adaptive immune response, for which reason targeting antigen to these cells is an important strategy for improvement of vaccine development. To this end, we explored recognition of DCs lectins by glycans. For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes...
January 31, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29385091/exploring-alternative-radiolabeling-strategies-for-sialic-acid-binding-immunoglobulin-like-lectin-9-peptide-68ga-ga-and-18f-alf-nota-siglec-9
#17
Olli Moisio, Riikka Siitonen, Heidi Liljenbäck, Elli Suomela, Sirpa Jalkanen, Xiang-Guo Li, Anne Roivainen
Amino acid residues 283-297 from sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) form a cyclic peptide ligand targeting vascular adhesion protein-1 (VAP-1). VAP-1 is associated with the transfer of leukocytes from blood to tissues upon inflammation. Therefore, analogs of Siglec-9 peptide are good candidates for visualizing inflammation non-invasively using positron emission tomography (PET). Gallium-68-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid (DOTA)-conjugated Siglec-9 has been evaluated extensively for this purpose...
January 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29374074/cd22-promotes-b-1b-cell-responses-to-t-cell-independent-type-2-antigens
#18
Karen M Haas, Kristen L Johnson, James P Phipps, Cardinal Do
CD22 (Siglec-2) is a critical regulator of B cell activation and survival. CD22-/- mice generate significantly impaired Ab responses to T cell-independent type 2 (TI-2) Ags, including haptenated Ficoll and pneumococcal polysaccharides, Ags that elicit poor T cell help and activate BCR signaling via multivalent epitope crosslinking. This has been proposed to be due to impaired marginal zone (MZ) B cell development/maintenance in CD22-/- mice. However, mice expressing a mutant form of CD22 unable to bind sialic acid ligands generated normal TI-2 Ab responses, despite significantly reduced MZ B cells...
January 26, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29342882/implication-of-soluble-forms-of-cell-adhesion-molecules-in-infectious-disease-and-tumor-insights-from-transgenic-animal-models
#19
REVIEW
Etsuro Ono, Toshimitsu Uede
Cell adhesion molecules (CAMs) are surface ligands, usually glycoproteins, which mediate cell-to-cell adhesion. They play a critical role in maintaining tissue integrity and mediating migration of cells, and some of them also act as viral receptors. It has been known that soluble forms of the viral receptors bind to the surface glycoproteins of the viruses and neutralize them, resulting in inhibition of the viral entry into cells. Nectin-1 is one of important CAMs belonging to immunoglobulin superfamily and herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29338152/generation-and-characterization-of-siglec-f-specific-monoclonal-antibodies
#20
Sima Shahmohammadi-Farid, Roya Ghods, Mahmood Jeddi-Tehrani, Ali-Ahmad Bayat, Nazanin Mojtabavi, Alireza Razavi, Amir-Hassan Zarnani
Siglec-F (SF) is a surface glycoprotein expressed by mouse eosinophils and induces caspase- and mitochondria-dependent apoptosis after engagement with its cognate ligand or specific antibodies. This targeting eosinophils by monoclonal antibodies may help diverse diseases associated with increased frequency of eosinophils including allergy and asthma. In this paper, production of murine and rat monoclonal antibodies (mAbs) against Siglec-F has been addressed. Balb/c mice were immunized with siglec-F1 (SF1) and siglec-F2 (SF2) synthetic peptides conjugated to a carrier protein...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
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