keyword
MENU ▼
Read by QxMD icon Read
search

Siglec

keyword
https://www.readbyqxmd.com/read/28619634/enhancement-of-siglec-8-expression-predicts-adverse-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#1
Chenzhang Ou, Li Liu, Jiajun Wang, Siyuan Dai, Yang Qu, Ying Xiong, Wei Xi, Jiejie Xu, Jianming Guo
PURPOSE: Sialic acid-binding immunoglobulin-like lectins (siglecs) family has important functions in tumor progression. The purpose of our study is to figure out the correlation between the expression level of Siglec-8 and prognosis of patients with clear cell renal cell carcinoma (ccRCC), and then to predict the overall survival (OS) via a novel nomogram. MATERIALS AND METHODS: A group of patients (n = 267) histologically diagnosed with ccRCC from Zhongshan Hospital were included into our study...
June 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28608355/-neuronal-glycolipids-regulate-glial-cell-division-negatively-during-development-and-following-a-lesion
#2
REVIEW
M Nieto-Sampedro, V C Muneton-Gomez
Glial cells in the central nervous system of adult mammals outnumber neurons 10-fold. Their number remains stationary throughout adulthood, controlled by the concomitant presence of mitogens and mitogen inhibitors. The most abundant inhibitor, neurostatin, is ganglioside GD1b O-acetylated on hydroxyl 9 of its outermost sialic acid. Neurostatin inhibited the proliferation of primary microglia and astroblasts in culture (cytostatic) as well as both rodent and human glioma cells (cytotoxic) at nanomolar concentrations...
June 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28556976/exploring-the-radiosynthesis-and-in-vitro-characteristics-of-68-ga-ga-dota-siglec-9
#3
Svend B Jensen, Meeri Käkelä, Lars Jødal, Olli Moisio, Aage K O Alstrup, Sirpa Jalkanen, Anne Roivainen
Vascular adhesion protein 1 is a leukocyte homing-associated glycoprotein, which upon inflammation rapidly translocates from intracellular sources to the endothelial cell surface. It has been discovered that the cyclic peptide residues 283-297 of sialic acid-binding IgG-like lectin 9 (Siglec-9) "CARLSLSWRGLTLCPSK" bind to vascular adhesion protein 1 and hence makes the radioactive analogues of this compound ([(68) Ga]Ga-DOTA-Siglec-9) interesting as a noninvasive visualizing marker of inflammation. Three different approaches to the radiosynthesis of [(68) Ga]Ga-DOTA-Siglec-9 are presented and compared with previously published methods...
May 30, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28465620/ivig-regulates-the-survival-of-human-but-not-mouse-neutrophils
#4
Christoph Schneider, Simone Wicki, Stefanie Graeter, Tankica M Timcheva, Christian W Keller, Isaak Quast, Danila Leontyev, Iglika K Djoumerska-Alexieva, Fabian Käsermann, Stephan M Jakob, Petya A Dimitrova, Donald R Branch, Richard D Cummings, Jan D Lünemann, Thomas Kaufmann, Hans-Uwe Simon, Stephan von Gunten
Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils via agonistic antibodies to Fas and Siglec-9. In this study, we compared the effects of IVIG on human and mouse neutrophils using different death assays. Different commercial IVIG preparations similarly induced cytokine-dependent death in human neutrophils, whereas they had no effects on the survival of either peripheral blood or bone marrow neutrophils from C57BL/6 or BALB/c mice...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28454648/the-siglec14-null-allele-is-associated-with-mycobacterium-tuberculosis-and-bcg-induced-clinical-and-immunologic-outcomes
#5
Andrew D Graustein, David J Horne, Jerry J Fong, Flavio Schwarz, Heather C Mefford, Glenna J Peterson, Richard D Wells, Munyaradzi Musvosvi, Muki Shey, Willem A Hanekom, Mark Hatherill, Thomas J Scriba, Nguyen Thuy Thuong Thuong, Nguyen Thi Hoang Mai, Maxine Caws, Nguyen Duc Bang, Sarah J Dunstan, Guy E Thwaites, Ajit Varki, Takashi Angata, Thomas R Hawn
Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains. The SIGLEC14 coding sequence is deleted in a high proportion of individuals, placing a SIGLEC5-like gene under the expression of the SIGLEC14 promoter (the SIGLEC14 null allele) and causing expression of a Siglec-5 like protein in monocytes and macrophages...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28416510/erythrocyte-sialoglycoproteins-engage-siglec-9-on-neutrophils-to-suppress-activation
#6
Anel Lizcano, Ismael Secundino, Simon Döhrmann, Ross Corriden, Cristina Rohena, Sandra Diaz, Pradipta Ghosh, Lingquan Deng, Victor Nizet, Ajit Varki
Healthy blood neutrophils are functionally quiescent in the bloodstream, have a short lifespan, and exit the circulation to carry out innate immune functions, or undergo rapid apoptosis and macrophage-mediated clearance to mitigate host tissue damage. Limitation of unnecessary intravascular neutrophil activation is also important to prevent serious inflammatory pathologies. Since neutrophils become easily activated after purification, we carried out ex vivo comparisons with neutrophils maintained in whole blood...
April 17, 2017: Blood
https://www.readbyqxmd.com/read/28386256/host-immune-responses-in-hiv-1-infection-the-emerging-pathogenic-role-of-siglecs-and-their-clinical-correlates
#7
REVIEW
Joanna Mikulak, Clara Di Vito, Elisa Zaghi, Domenico Mavilio
A better understanding of the mechanisms employed by HIV-1 to escape immune responses still represents one of the major tasks required for the development of novel therapeutic approaches targeting a disease still lacking a definitive cure. Host innate immune responses against HIV-1 are key in the early phases of the infection as they could prevent the development and the establishment of two hallmarks of the infection: chronic inflammation and viral reservoirs. Sialic acid-binding immunoglobulin-like lectins (Siglecs) belong to a family of transmembrane proteins able to dampen host immune responses and set appropriate immune activation thresholds upon ligation with their natural ligands, the sialylated carbohydrates...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28382168/development-of-sialic-acid-coated-nanoparticles-for-targeting-cancer-and-efficient-evasion-of-the-immune-system
#8
Young-Hwa Kim, Kyung Hyun Min, Zhantong Wang, Jihoon Kim, Orit Jacobson, Peng Huang, Guizhi Zhu, Yijing Liu, Bryant Yung, Gang Niu, Xiaoyuan Chen
Evading the reticuloendothelial system (RES) remains a critical challenge in the development of efficient delivery and diagnostic systems for cancer. Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), which is known as one of the significant regulators of phagocytic evasion. Accordingly, we prepared different surface-modified gold nanoparticles (AuNPs) and investigated the effects of sialic acid on cellular and immune responses of nanoparticles in vitro and in vivo...
2017: Theranostics
https://www.readbyqxmd.com/read/28378743/siglec-7-restores-%C3%AE-cell-function-and-survival-and-reduces-inflammation-in-pancreatic-islets-from-patients-with-diabetes
#9
Gitanjali Dharmadhikari, Katharina Stolz, Michael Hauke, Noel G Morgan, Ajit Varki, Eelco de Koning, Sørge Kelm, Kathrin Maedler
Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression. Identification of targets, which both prevent macrophage activation and infiltration into islets and restore β-cell functionality is essential for effective diabetes therapy. We report that certain Sialic-acid-binding immunoglobulin-like-lectins (siglecs) are expressed in human pancreatic islets in a cell-type specific manner...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374980/chemical-synthesis-and-evaluation-of-a-disialic-acid-containing-dextran-polymer-as-an-inhibitor-for-the-interaction-between-siglec-7-and-its-ligand
#10
Sho Yamaguchi, Atsushi Yoshimura, Yu Yasuda, Airi Mori, Hiroshi Tanaka, Takashi Takahashi, Ken Kitajima, Chihiro Sato
A new sialic acid (Sia)-containing glycopolymer-a fluorescent probe with high-density disialic acid (diSia) on the surface of polysaccharide dextran (diSia-Dex)-was synthesized as a key molecule to regulate the Sia recognition lectins, Siglecs, that are involved in the immune system. According to our original methods, diSia was synthesized by α-selective sialylation, and a dextran template possessing terminal acetylenes and amino groups was prepared. A diSia and a fluorescent molecule were subsequently introduced to surface-modified dextran by Hüisgen reaction and amidation, respectively...
April 4, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28374962/novel-human-cd22-siglec-2-ligands-with-a-triazole-glycoside
#11
Horst Prescher, Astid Schweizer, Elena Kuhfeldt, Lars Nitschke, Reinhard Brossmer
CD22 is a member of the Siglec family. Considerable attention has been drawn to the design and synthesis of novel Siglec ligands to explore target biology and innovative therapies. In particular, CD22 ligand targeted nanoparticles with therapeutic functions have been proven successful in preclinical settings for blood cancers, autoimmune diseases, and tolerance induction. Here we report the design, synthesis and affinity evaluation of a novel class of Siglec ligands, namely sialic acid derivatives with a triazole replacing the natural glycoside oxygen...
April 4, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28369504/siglec-8-and-siglec-9-binding-specificities-and-endogenous-airway-ligand-distributions-and-properties
#12
Huifeng Yu, Anabel Gonzalez-Gil, Yadong Wei, Steve M Fernandes, Ryan N Porell, Katarina Vajn, James C Paulson, Corwin M Nycholat, Ronald L Schnaar
Siglecs are transmembrane sialoglycan binding proteins, most of which are expressed on leukocyte subsets and have inhibitory motifs that translate cell surface ligation into immune suppression. In humans, Siglec-8 on eosinophils, mast cells and basophils and Siglec-9 on neutrophils, monocytes and some T-cells, mediate immune cell death, inhibition of immune mediator release and/or enhancement of anti-inflammatory mediator release. Endogenous sialoglycan ligands in tissues, mostly uncharacterized, engage siglecs on leukocytes to inhibit inflammation...
July 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28283679/the-immunological-function-of-cd52-and-its-targeting-in-organ-transplantation
#13
REVIEW
Yang Zhao, Huiting Su, Xiaofei Shen, Junfeng Du, Xiaodong Zhang, Yong Zhao
INTRODUCTION: CD52 (Campath-1 antigen), a glycoprotein of 12 amino acids anchored to glycosylphosphatidylinositol, is widely expressed on the cell surface of immune cells, such as mature lymphocytes, natural killer cells (NK), eosinophils, neutrophils, monocytes/macrophages, and dendritic cells (DCs). The anti-CD52 mAb, alemtuzumab, was used widely in clinics for the treatment of patients such as organ transplantation. In the present manuscript, we will briefly summarize the immunological function of CD52 and discuss the application of anti-CD52 mAb in transplantation settings...
March 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28277099/cd169-is-a-marker-for-highly-pathogenic-phagocytes-in-multiple-sclerosis
#14
Jeroen Fj Bogie, Ellen Boelen, Els Louagie, Peter Delputte, Dirk Elewaut, Jack van Horssen, Jerome Ja Hendriks, Niels Hellings
BACKGROUND: Phagocytes, such as macrophages and microglia, are key effector cells in the pathophysiology of multiple sclerosis (MS). It is widely accepted that they instigate and promote neuroinflammatory and neurodegenerative events in MS. An increasing amount of studies indicate that Siglec-1, also known CD169, is a marker for activated phagocytes in inflammatory disorders. OBJECTIVE: In this study, we set out to define how CD169(+) phagocytes contribute to neuroinflammation in MS...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28273363/siglec-9-is-upregulated-in-rheumatoid-arthritis-and-suppresses-collagen-induced-arthritis-through-reciprocal-regulation-of-th17-treg-cell-differentiation
#15
Xiaoyuan Wang, Dan Liu, Yaxian Ning, Jiayu Liu, Xin Wang, Ran Tu, Haili Shen, Qun Chen, Yongmin Xiong
Sialic acid-binding Ig-like lectin-9 (Siglec-9) is a novel sialic acid-binding member of the immunoglobulin superfamily, and is broadly expressed on immune cells, which can inhibit both innate and adaptive immune responses through immunoreceptor tyrosine-based inhibitory motifs. However, the exact role of Siglec-9 in the pathogenesis of rheumatoid arthritis (RA) remains unknown. In this study, we determined soluble Siglec-9 (sSiglec-9) levels in the serum and synovial fluid of RA patients, and evaluated the relation between sSiglec-9 levels and clinical factors...
March 8, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28272428/secreted-ectodomain-of-siglec-9-and-mcp-1-synergistically-improve-acute-liver-failure-in-rats-by-altering-macrophage-polarity
#16
Takanori Ito, Masatoshi Ishigami, Yoshihiro Matsushita, Marina Hirata, Kohki Matsubara, Tetsuya Ishikawa, Hideharu Hibi, Minoru Ueda, Yoshiki Hirooka, Hidemi Goto, Akihito Yamamoto
Effective treatments for acute liver failure (ALF) are still lacking. We recently reported that a single intravenous administration of serum-free conditioned medium from stem cells derived from human exfoliated deciduous teeth (SHED-CM) into the D-galactosamine (D-Gal)-induced rat ALF model improves the liver injury. However, the specific factors in SHED-CM that are responsible for resolving ALF remain unclear. Here we found that depleting SHED-CM of two anti-inflammatory M2 macrophage inducers-monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (sSiglec-9)-abolished its ability to resolve rat ALF...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28263753/the-maternal-plasma-proteome-changes-as-a-function-of-gestational-age-in-normal-pregnancy-a-longitudinal-study
#17
Roberto Romero, Offer Erez, Eli Maymon, Piya Chaemsaithong, Zhonghui Xu, Percy Pacora, Tinnakorn Chaiworapongsa, Bogdan Done, Sonia S Hassan, Adi L Tarca
OBJECTIVE: Pregnancy is accompanied by dramatic physiological changes in maternal plasma proteins. Characterization of the maternal plasma proteome in normal pregnancy is an essential step for understanding changes to predict pregnancy outcome. The objective of this study was to describe maternal plasma proteins that change in abundance with advancing gestational age and determine biological processes that are perturbed in normal pregnancy. STUDY DESIGN: A longitudinal study included 43 normal pregnancies that had a term delivery of an infant who was appropriate for gestational age without maternal or neonatal complications...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28258691/viewing-siglecs-through-the-lens-of-tumor-immunology
#18
REVIEW
Isabella Fraschilla, Shiv Pillai
Many Siglecs function as inhibitory receptors on innate and adaptive immune cells and may contribute to the attenuation of immune responses to tumors. Siglec 9 on neutrophils and Siglec 7 on NK cells are prominent examples of inhibitory Siglecs that can potentially dampen anti-tumor immunity. CD169 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors. It can potentially contribute to both the attenuation as well as the facilitation of anti-tumor immunity...
March 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28257233/three-unique-interstitial-macrophages-in-the-murine-lung-at-steady-state
#19
Sophie L Gibbings, Stacey M Thomas, Shaikh M Atif, Alexandra L McCubbrey, A Nicole Desch, Thomas Danhorn, Sonia M Leach, Donna L Bratton, Peter M Henson, William J Janssen, Claudia V Jakubzick
RATIONALE: The current paradigm in macrophage biology is that some tissues mainly contain macrophages from embryonic origin such as microglia in the brain, while other tissues contain postnatal-derived macrophages, such as the gut. However, in the lung and in other organs such as the skin, there are both embryonic and postnatal-derived macrophages. OBJECTIVES: In this study, we demonstrate in the steady-state lung that the mononuclear phagocyte system is comprised of three newly identified interstitial macrophages (IMs), alveolar macrophages (AMs), dendritic cells (DCs) and few extravascular monocytes...
March 3, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28246365/role-of-eosinophils-and-tumor-necrosis-factor-alpha-in-interleukin-25-mediated-protection-from-amebic-colitis
#20
Zannatun Noor, Koji Watanabe, Mayuresh M Abhyankar, Stacey L Burgess, Erica L Buonomo, Carrie A Cowardin, William A Petri
The parasite Entamoeba histolytica is a cause of diarrhea in infants in low-income countries. Previously, it was shown that tumor necrosis factor alpha (TNF-α) production was associated with increased risk of E. histolytica diarrhea in children. Interleukin-25 (IL-25) is a cytokine that is produced by intestinal epithelial cells that has a role in maintenance of gut barrier function and inhibition of TNF-α production. IL-25 expression was decreased in humans and in the mouse model of amebic colitis. Repletion of IL-25 blocked E...
February 28, 2017: MBio
keyword
keyword
75205
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"