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https://www.readbyqxmd.com/read/29140564/%C3%AE-catenin-and-il-1%C3%AE-dependent-cxcl10-production-drives-progression-of-disease-in-a-mouse-model-of-congenital-hepatic-fibrosis
#1
Eleanna Kaffe, Romina Fiorotto, Francesca Pellegrino, Valeria Mariotti, Mariangela Amenduni, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco, Carlo Spirli
Congenital Hepatic Fibrosis (CHF), a genetic disease caused by mutations in the PKHD1 gene, encoding for the protein fibrocystin (FPC), is characterized by biliary dysgenesis, progressive portal fibrosis, and by a PKA-mediated activating phosphorylation of β-Catenin at Ser675. Biliary structures of Pkhd1(del4/del4) mice, a mouse model of CHF, secrete CXCL10 a chemokine able to recruit macrophages. The aim of this study is to clarify whether CXCL10 plays a pathogenetic role in disease progression in CHF/CD and to understand the mechanisms leading to increased CXCL10 secretion...
November 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29127962/minimally-invasive-hepatobiliary-surgery
#2
REVIEW
Omid Madadi-Sanjani, Claus Petersen, Benno Ure
Comparative studies and large-scale case series that confirm the advantages of laparoscopy in children with hepatobiliary diseases are scarce, and the use of laparoscopy remains a matter of debate. This article reviews the current literature on the role of laparoscopic and robotic surgery in pediatric patients with choledochal cyst, biliary atresia, gallbladder diseases, and hepatobiliary malignancies. Studies were identified through a search of the MEDLINE database. Laparoscopy may be beneficial for resection of choledochal cyst and cholecystectomy...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29127876/differentiating-biliary-cystadenomas-from-benign-hepatic-cysts-preliminary-analysis-of-new-predictive-imaging-features
#3
Mark D Kovacs, Douglas H Sheafor, Philip F Burchett, Melissa M Picard, Andrew D Hardie
OBJECTIVE: To identify performance of imaging features in differentiating hepatic cysts from biliary cystadenomas of the liver. METHODS: 25 pathologically confirmed hepatic cystic lesions (hepatic cysts or biliary cystadenomas) were evaluated retrospectively and predetermined imaging features assessed for performance in differentiation. RESULTS: Any septation which arose from a cyst wall without external indentation had a very high association with biliary cystadenoma, while the presence of a thick septation had only a moderate association...
November 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29121977/intrahepatic-biliary-cystadenoma-mimicking-hydatid-cyst-of-liver-a-clinicopathologic-study-of-six-cases
#4
Zubair Ahmad, Nasir Uddin, Wasim Memon, Jamshid Abdul-Ghafar, Arsalan Ahmed
BACKGROUND: Intrahepatic biliary cystadenomas are rare hepatic neoplasms, which are usually cystic. These tumors are often misdiagnosed as simple liver cysts and hydatid cysts clinically and radiologically owing to nonspecific clinical and radiologic features. These tumors require complete resection, as recurrence and malignant transformation can occur following incomplete excision. It is essential that these tumors be diagnosed accurately so that they can be adequately excised. METHODS: Clinical and radiological features of six cases of biliary cystadenoma are described...
November 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29107478/intrabiliary-rupture-of-hepatic-hydatid-cyst-leading-to-biliary-obstruction-cholangitis-and-septicemia
#5
Furkan Ufuk, Mehmet Duran
No abstract text is available yet for this article.
October 26, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29105184/differentiation-between-cystic-biliary-atresia-and-choledochal-cyst-a-retrospective-analysis
#6
Jue Tang, Dan Zhang, Wei Liu, Ji-Xiao Zeng, Jia-Kang Yu, Yi Gao
AIM: Cystic biliary atresia (CBA) can be easily misdiagnosed as choledochal cyst (CC). Some patients have already progressed to severe liver fibrosis and missed the optimal surgical time, when the differential diagnosis is made. We aim to determine the differentiation between CBA and CC, and to validate the value of aspartate aminotransferase-to-platelet ratio index (APRI) in the assessment of liver fibrosis and prediction of post-operative outcome for infants with biliary cystic malformations (BCMs)...
November 3, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29090424/spontaneous-external-biliary-fistula-arising-from-an-intrahepatic-duct
#7
Naoto Mizumura, Satoshi Okumura, Hiroshi Tsuchihashi, Masao Ogawa, Masayasu Kawasaki
A spontaneous external biliary fistula is most commonly a cholecystocutaneous fistula secondary to acute cholecystitis. A fistula arising from an intrahepatic duct is extremely rare. An 87-year-old man presented with swelling of the epigastric region and right upper quadrant abdomen. He had a history of cholecystectomy and endoscopic sphincterotomy. After antibiotic treatment and surgical opening of both lesions, abdominal computed tomography demonstrated a soft tissue mass cephalad to the umbilicus. We excised the mass, and found it to be associated with a fistula through the linea alba...
October 31, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29089716/robotic-roux-en-y-bilioenteric-reconstruction
#8
Sanjay Goja, Manoj K Singh, Sujeet Saha, Varun Mahabaleshwar, Arvinder S Soin
The authors report technical details of robotic bilioenteric reconstruction done for variable indications: choledochal cyst and biliary stricture. Robotic bilioenteric anastomosis as alternative to open reconstruction, offers advantages of minimal access surgery without compromising the precision of open surgery for hilar dissection and reconstruction. Both patients recovered uneventfully and remain symptom-free 18 and 15 months after surgery.
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29089712/management-of-complicated-choledochal-cyst-in-an-adult-with-situs-inversus-totalis-diagnostic-difficulties-and-technical-notes
#9
Ajeet Pratap Maurya, Saket Kumar, Vishal Gupta, Abhijit Chandra
Situs inversus totalis is the mirror image of situs solitus, the normal position of abdominal and thoracic viscera. Many associated intraabdominal anomalies have been described with this condition. However, association of choledochal cyst with situs inversus has never been reported. Diagnosis and surgical procedures for abdominal pathology in patients with situs inversus totalis are technically more complicated and pose unique challenges because of left-right transposition of the visceral organs. The choledochal cyst is usually diagnosed in the neonatal period or during childhood...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29089679/embryonal-rhabdomyosarcoma-of-the-biliary-tree-a-rare-cause-of-obstructive-jaundice-in-children-which-can-mimic-choledochal-cysts
#10
Dhara J Kinariwala, Andrew Y Wang, Patrick D Melmer, William P McCullough
Jaundice in children is more often due to hepatic disease than obstruction. Differential considerations for obstructive jaundice in children include choledocholithiasis, choledochal cysts and rare neoplasms. Rhabdomyosarcoma, the most common soft tissue sarcoma in pediatric patients, typically involves the head and neck, genitourinary system and extremities. Embryonal rhabdomyosarcoma of the biliary tree is a rare entity. We present a 3-year-old boy with abrupt onset obstructive jaundice. Although initial imaging suggested a dilated biliary system with fusiform common bile duct, sludge, and possible cholelithiasis, endoscopic retrograde cholangiopancreatogram (ERCP) diagnosed a common bile duct embryonal rhabdomyosarcoma and further imaging showed involvement of the cystic duct...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29062832/mucinous-cystadenoma-a-rare-hepatic-tumor-in-a-child
#11
Danielle A Ferraguti, Molly McGetrick, Ivan Zendejas, David Hernandez-Gonzalo, Regino Gonzalez-Peralta
Mucinous cystadenomas (MCAs) of the liver (also called hepatic biliary cystadenomas) are rare tumors that comprise about 5% of cystic masses of the liver in adults. These slow-growing lesions most commonly occur in middle-aged individuals, with a female sex predominance. Herein, we present a MCA in a 6-year-old male, one of only very few such cases described in the pediatric literature to date. Although MCAs are generally considered benign lesions, malignant transformation rarely occurs. The recurrence rate is high when partial cyst excision is performed...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29049233/pediatric-types-i-and-vi-choledochal-cysts-complicated-with-acute-pancreatitis-and-spontaneous-perforation-a-case-report-and-literature-review
#12
Ching-Chung Tsai, Po-Kai Huang, Hsien-Kuan Liu, Yu-Tsun Su, Ming-Chun Yang, Ming-Lun Yeh
RATIONALE: Choledochal cysts are a congenital disorder of the common bile duct that can cause progressive biliary obstruction and biliary cirrhosis. They were classified by Todani into five types. Of these, type VI choledochal cysts are rarely reported in the literature. PATIENT CONCERNS: A 22-month-old girl presented with intermittent epigastralgia for approximately 10 days and fever for three days. Fasting and total parenteral nutrition were administered after admission...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29035250/rare-but-life-threatening-complication-of-hydatid-disease
#13
Fatih Karakaya, Çağdaş Kalkan, Melek Karakaya, Necati Örmeci
Cystic echinococcosis is an infectious disease that is potentially associated with the biliary tract. Of thousand cases of hydatid cysts that were successfully treated by the Örmeci method, only two presented with cholangitis subsequent to the percutaneous treatment. These cases were treated with endoscopic retrograde cholangiopancreatography, and this study provides details regarding the clear fistulization of hydatid cysts into the biliary tract.
September 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29033069/surgery-for-hepatic-hidatidosis-risk-factors-and-variables-associated-with-postoperative-morbidity-overview-of-the-existing-evidence
#14
Carlos Manterola, Tamara Otzen, Gloria Muñoz, Martín Alanis, Eileen Kruuse, Gustavo Figueroa
There are few publications related to postoperative morbidity in hepatic hydatidosis and these have mixed results. The aim of this study was to determine risk and protective factors of postoperative morbidity in patients operated on for hepatic hydatidosis. A comprehensive review was made of the evidence, based on systematic reviews, clinical analyses and observational studies, obtained from the Trip Database, BVS, SciELO, Cochrane Central Register of Controlled Trials, WoS, MEDLINE, EMBASE, SCOPUS, EBSCOhost, IBECS, ePORTUGUESe, LILACS and WHOLIS...
October 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29031964/-the-thoracic-surgeon-and-the-management-of-the-bronchial-biliary-fistula-of-hydatid-origin
#15
S Rabiou, L Belliraj, F Z Ammor, I Issoufou, B Sylla, M Lakranbi, Y Ouadnouni, D Benajah, M Smahi
INTRODUCTION: The bronchial biliary fistula surgery is a major one, always going with a higher rate of complication especially in case of bile duct obstruction. The aim of this study is to find out the contribution of endoscopic sphincterotomy while reporting the results of surgical treatment of bronchial biliary fistulae by exclusive thoracotomy. METHODS: This was a retrospective study, which took place in the Department of Thoracic Surgery, University Hospital Hassan II, from January 2009 to March 2016...
October 12, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29024292/hepatic-cystic-echinococcosis-in-australia-an-update-on-diagnosis-and-management
#16
REVIEW
Ben Keong, Bruce Wilkie, Tom Sutherland, Adrian Fox
BACKGROUND: Echinococcosis is an uncommonly encountered zoonotic disease caused by the taeniid Echinococcus. The only endemic species in Australia, Echinococcus granulosus, forms cysts in the liver in 70% of cases. The aim of this study was to review the literature to provide an evidence-based narrative update on the diagnosis and management of hepatic cystic echinococcosis in Australia. METHODS: We reviewed the literature, utilizing multiple research databases and citation tracking...
October 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29016404/hepatobiliary-mucinous-cystic-neoplasms-with-ovarian-type-stroma-so-called-hepatobiliary-cystadenoma-cystadenocarcinoma-clinicopathologic-analysis-of-36-cases-illustrates-rarity-of-carcinomatous-change
#17
Brian Quigley, Michelle D Reid, Burcin Pehlivanoglu, Malcolm H Squires, Shishir Maithel, Yue Xue, Choi Hyejeong, Gizem Akkas, Takashi Muraki, David A Kooby, Juan M Sarmiento, Ken Cardona, Aarti Sekhar, Alyssa Krasinskas, Volkan Adsay
The literature is highly conflicting on hepatobiliary mucinous cystic neoplasms (MCNs), aka "hepatobiliary cystadenoma/cystadenocarcinoma," largely because ovarian stroma (OS) was not a requirement until WHO-2010 and is not widely applied even today. In this study, MCNs (with OS) accounted for 24 of 229 (11%) resected hepatic cysts in one institution. Eight of the 32 (25%) cysts that had been originally designated as hepatobiliary cystadenoma/cystadenocarcinoma at the time of diagnosis proved not to have an OS during this review and were thus re-classified as non-MCN...
October 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29016329/preliminary-evaluation-of-percutaneous-treatment-of-echinococcal-cysts-without-injection-of-scolicidal-agent
#18
Giovanni Firpo, Ambra Vola, Raffaella Lissandrin, Francesca Tamarozzi, Enrico Brunetti
Puncture, Aspiration, Injection of scolicidal agent, Re-aspiration is the most widely used percutaneous treatment of cystic echinococcosis (CE). Among its perceived risks is chemical sclerosing cholangitis, a serious complication due to the caustic effect of the scolicidal solution on the biliary tree, when a patent cystobiliary fistula occurs. To simplify the protocol, we decided to omit injection and reaspiration of the scolicidal agent and to implement a full course of albendazole (ABZ) therapy instead of the routine 1-month ABZ prophylaxis...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28948113/one-of-the-largest-pancreatic-pseudocysts-in-the-literature-a-case-report
#19
Sulaiman Alhassan, Shifa Umar, Mark Lega
The pancreatic pseudocyst is a pancreatic fluid collection which classically develops due to acute or chronic pancreatitis. A 68-year-old male with the remote history of alcohol abuse presented with abdominal pain secondary to acute pancreatitis. The first computed tomography (CT) of the abdomen showed acute necrotizing pancreatitis. He was initially treated conservatively. Repeat CT of the abdomen after two weeks revealed a peripancreatic fluid collection of 20x12x10 cm. One month later, he became septic following biliary stent placement...
July 20, 2017: Curēus
https://www.readbyqxmd.com/read/28940454/choledochal-cyst-with-17q12-chromosomal-duplication
#20
Radana Kotalova, Petra Dusatkova, Jana Drabova, Lenka Elblova, Tomas Dedic, Ondrej Cinek, Jan Lebl, Stepanka Pruhova
The 17q12 chromosomal region carries the HNF1B gene, mutations of which cause various conditions. When searching for HNF1B/17q12 rearrangements among children with biliary atresia and/or choledochal cysts, we identified a male proband carrying a 17q12 duplication spanning 1698 kb that included 24 genes from TBC1D3C to HNF1B. The boy presented with cholestatic jaundice at the age of 2 weeks due to a choledochal cyst sized 15 ×12 mm (type Ia according to the Todani classification). He underwent a shunt surgery consisting of a hepaticojejunostomy using Roux-en-Y loop at the age of 2 months, which led to a permanent relief of cholestasis...
September 22, 2017: Annals of Human Genetics
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