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https://www.readbyqxmd.com/read/29156780/baicalein-inhibits-progression-of-osteosarcoma-cells-through-inactivation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#1
Guo Dai, Di Zheng, Qianliang Wang, Jian Yang, Gaiwei Liu, Qi Song, Xiangran Sun, Chunjie Tao, Qingzhu Hu, Tian Gao, Ling Yu, Weichun Guo
Osteosarcoma is a very common type of malignant bone tumor in children and young adults and aberrant activation of Wnt/β-catenin signaling pathway has been discovered in osteosarcoma. The traditional Chinese medicine baicalein was proved to have anti-proliferative and anti-metastatic properties in osteosarcoma, but the mechanism remained poorly understood. In the present study, we assessed the effects of baicalein on osteosarcoma and detected the potential molecular mechanism. We found that baicalein significantly suppressed the proliferation of osteosarcoma cells in a concentration- and time-dependent manner...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156746/tssc3-represses-self-renewal-of-osteosarcoma-stem-cells-and-nanog-expression-by-inhibiting-the-src-akt-pathway
#2
Guang-Ning Yan, Xue-Feng Tang, Xian-Chao Zhang, Ting He, Yu-Sheng Huang, Xi Zhang, Gang Meng, De-Yu Guo, Yang-Fan Lv, Qiao-Nan Guo
Osteosarcoma is the most common type of bone cancer, and the second leading cause of cancer-related death in children and young adults. Osteosarcoma stem cells are essential for osteosarcoma initiation, metastasis, chemoresistance and recurrence. In the present study, we report that: 1) higher TSSC3 expression indicates a better prognosis for osteosarcoma patients, and; 2) overexpression of TSSC3 significantly decreases sphere-forming capacity, tumor initiation, stemness-related surface markers and Nanog expression in osteosarcoma cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156647/effects-of-nutritional-interventions-during-pregnancy-on-infant-and-child-cognitive-outcomes-a-systematic-review-and-meta-analysis
#3
REVIEW
Rachael M Taylor, Shanna M Fealy, Alessandra Bisquera, Roger Smith, Clare E Collins, Tiffany-Jane Evans, Alexis J Hure
BACKGROUND: Epidemiological studies have demonstrated that folate, iodine and iron intake during pregnancy impacts on foetal brain development and cognitive function. However, in human studies, the relationship with other dietary nutrients is less clear. OBJECTIVE: This systematic review aims to critically appraise the current literature and meta-analyses results from nutritional interventions during pregnancy that aimed to optimise infant and child cognitive outcomes...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29156632/neurotropism-in-vitro-and-mouse-models-of-severe-and-mild-infection-with-clinical-strains-of-enterovirus-71
#4
Pin Yu, Linlin Bao, Lili Xu, Fengdi Li, Qi Lv, Wei Deng, Yanfeng Xu, Chuan Qin
Enterovirus 71 (EV71) is a common etiological agent of hand, foot, and mouth disease and fatal neurological diseases in children. The neuropathogenicity of severe EV71 infection has been documented, but studies comparing mouse models of severe and mild EV71 infection are lacking. The aim of the study was to investigate the neurovirulence of EV71 strains and the differences in serum cytokine and chemokine levels in mouse models of severe and mild EV71 infection. Nine EV71 isolates belonging to the C4 subgenogroup (proposed as genotype D) displayed infectivity in human neuroblastoma SK-N-SH cells; moreover, ultrastructural observation confirmed viral particle replication...
November 20, 2017: Viruses
https://www.readbyqxmd.com/read/29156582/in-memoriam-paolo-cappa
#5
EDITORIAL
Eduardo Palermo, Stefano Rossi, Fabrizio Patanè, Jeffrey Laut, Maurizio Porfiri
Prof. Paolo Cappa passed away on 26 August 2016, at the age of 59, after a long and courageous fight against cancer. Paolo Cappa was a Professor in Mechanical and Thermal Measurements and Experimental Biomechanics in the Department of Mechanical and Aerospace Engineering of Sapienza University of Rome, where he had also served as the Head of the Department, and a Research Professor in the Department of Mechanical and Aerospace Engineering of New York University Tandon School of Engineering. During his intense, yet short, career, he made several significant scientific contributions within the discipline of Mechanical and Thermal Measurements, pioneering fundamental applications to Biomechanics...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156548/patient-provider-communication-and-counseling-about-gestational-weight-gain-and-physical-activity-a-qualitative-study-of-the-perceptions-and-experiences-of-latinas-pregnant-with-their-first-child
#6
Ana Cristina Lindsay, Sherrie F Wallington, Mary L Greaney, Marcia M Tavares Machado, Gabriela P De Andrade
Latina women in the United States (U.S.) are disproportionately affected by obesity and are more likely to begin pregnancy overweight and gain excessive weight during pregnancy. The prenatal care period represents a window of opportunity for women to access the healthcare system and receive preventive services, education, nutritional support, and other social services to improve pregnancy outcomes. Excessive gestational weight gain (GWG) has numerous negative short- and long-term consequences for both the mother and newborn...
November 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156530/microrna-373-facilitates-hsv-1-replication-through-suppression-of-type-i-ifn-response-by-targeting-irf1
#7
Yiting Xie, Songlin He, Jinhua Wang
Herpes simplex virus type 1 (HSV-1) had led to kinds of clinical disorders and became an important cause of morbidity and mortality worldwide, such as herpetic gingivostomatitis in children. Previous studies reported that HSV-1 infection is common and has evolved a variety of mechanisms to evade the immune system, such as dysregulation of miRNAs. However, reports concerning the role of miRNA in HSV-1infection are limited. Here, we report that a host microRNA, miR-373, was significantly upregulated by HSV-1 infection in Hela cells and patients with herpetic gingivostomatitis and it facilitated HSV-1 replication in vitro...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156484/-perioperative-intravenous-fluid-therapy-in-children
#8
Robert Sümpelmann
The objective of this consensus-based S1 Guideline for perioperative fluid therapy in children is to maintain or re-establish the child's homeostasis. Therefore, the perioperative fasting times should be as short as possible to prevent patient discomfort, dehydration, and ketoacidosis. For the intraoperative background infusion a physiologically composed balanced isotonic electrolyte solution (BS) with 1 - 2.5% glucose is recommended to maintain normal glucose concentrations and to avoid hyponatremia, hyperchloremia, and lipolysis...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29156415/patterns-of-food-and-physical-activity-environments-related-to-children-s-food-and-activity-behaviors-a-latent-class-analysis
#9
Robin S DeWeese, Punam Ohri-Vachaspati, Marc A Adams, Jonathan Kurka, Seung Yong Han, Michael Todd, Michael J Yedidia
Relationships between food and physical activity (PA) environments and children's related behaviors are complex. Latent class analyses derived patterns from proximity to healthy and unhealthy food outlets, PA facilities and parks, and counts of residential dwellings and intersections. Regression analyses examined whether derived classes were related to food consumption, PA, and overweight among 404 low-income children. Compared to children living in Low PA-Low Food environments, children in High Intersection&Parks-Moderate Density&Food, and High Density-Low Parks-High Food environments, had significantly greater sugar-sweetened beverage consumption (ps<0...
November 17, 2017: Health & Place
https://www.readbyqxmd.com/read/29156409/it-s-in-the-details-the-role-of-selective-discussion-in-forgetting-of-children-s-autobiographical-memories
#10
Ruth Glynn, Karen Salmon, Jason Low
This experiment investigated whether retrieval-induced forgetting (RIF) would be found in children's self-generated autobiographical memory recall. An adapted version of the RIF paradigm for adults' autobiographical memories was administered to 8- and 9-year-old children (N = 65). We hypothesized that RIF would be found in terms of both number of memories recalled and amount of memory detail reported. The relationship between memory detail at the retrieval practice phase and RIF magnitude was also investigated...
November 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29156389/assessing-working-memory-in-children-with-adhd-minor-administration-and-scoring-changes-may-improve-digit-span-backward-s-construct-validity
#11
Erica L Wells, Michael J Kofler, Elia F Soto, Hillary S Schaefer, Dustin E Sarver
BACKGROUND: Pediatric ADHD is associated with impairments in working memory, but these deficits often go undetected when using clinic-based tests such as digit span backward. AIMS: The current study pilot-tested minor administration/scoring modifications to improve digit span backward's construct and predictive validities in a well-characterized sample of children with ADHD. METHODS AND PROCEDURES: WISC-IV digit span was modified to administer all trials (i...
November 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29156379/evaluating-the-immediate-effects-of-wearing-foot-orthotics-in-children-with-joint-hypermobility-syndrome-jhs-by-analysis-of-temperospatial-parameters-of-gait-and-dynamic-balance-a-preliminary-study
#12
P McDermott, E Wolfe, C Lowry, K Robinson, H P French
Joint Hypermobility Syndrome (JHS) in children, presents with increased joint range of motion and can lead to altered gait strategies and reduced dynamic balance. Despite limited evidence foot orthoses are sometimes prescribed to patients with JHS with the aim to improve the stability of their gait pattern and theoretically reduce associated symptoms of fatigue and joint pain. The purpose of this study was therefore to analyse the immediate effects of 'off the shelf' orthoses on temporospatial parameters of gait and dynamic balance in this cohort...
November 15, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29156378/effect-of-robotic-assisted-gait-rehabilitation-on-dynamic-equilibrium-control-in-the-gait-of-children-with-cerebral-palsy
#13
L Wallard, G Dietrich, Y Kerlirzin, J Bredin
Due to the intensity and repetition of movement, roboticassisted gait training therapy could have a beneficial effect on the recovery and improvement of postural and locomotor functions of the patient. This study sought to highlight the effects of robotic-assisted gait rehabilitation in gait of children with Cerebral Palsy (CP). We analyzed the different strategies before and after this rehabilitation which was used in order to generate forward motion while maintaining balance. Data were collected by a motion analysis system (Vicon® - Oxford Metrics, Oxford, UK)...
November 11, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29156342/a-prospective-cohort-study-of-the-association-between-bisphenol-a-exposure-and-the-serum-levels-of-liver-enzymes-in-children
#14
Seonhwa Lee, Hye Ah Lee, Bomi Park, Hyejin Han, Bo Hyun Park, Se Young Oh, Young Sun Hong, Eun Hee Ha, Hyesook Park
BACKGROUND: Bisphenol A (BPA) is an endocrine disrupter that acts in an estrogen-like manner. Few studies have investigated the association between urinary BPA concentrations and adverse liver function. Additionally, most studies were cross-sectional in nature and included only adults. OBJECTIVES: We evaluated BPA exposure levels and prospectively explored the association between BPA exposure and liver function in children. METHODS: Data were retrieved from the ongoing prospective Ewha Birth and Growth Cohort Study...
November 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29156335/thyroid-disruption-and-reduced-mental-development-in-children-from-an-informal-e-waste-recycling-area-a-mediation-analysis
#15
Lian Liu, Bo Zhang, Kun Lin, Yuling Zhang, Xijin Xu, Xia Huo
This paper aims to evaluate the effects of thyroid disruption on the mental development of children. A total of 258 three-year-old children in Guiyu (e-waste-exposed group) and Nanao (reference group), China were examined. FT3, FT4, TSH, lead (BPb) and cadmium (BCd) in blood were determined, and cognitive and language scores of children were assessed based on the Bayley Scales of Infant Development III. Stepwise multiple regression was used to estimate the relationship between heavy metals and cognitive and language scores; mediation analysis was performed to determine whether thyroid disruption was mechanistically involved...
November 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/29156323/early-life-exposure-to-per-and-polyfluoroalkyl-substances-and-mid-childhood-lipid-and-alanine-aminotransferase-levels
#16
Ana M Mora, Abby F Fleisch, Sheryl L Rifas-Shiman, Jennifer A Woo Baidal, Larissa Pardo, Thomas F Webster, Antonia M Calafat, Xiaoyun Ye, Emily Oken, Sharon K Sagiv
BACKGROUND: Growing evidence suggests that exposure to per- and polyfluoroalkyl substances (PFASs) may disrupt lipid homeostasis and liver function, but data in children are limited. OBJECTIVE: We examined the association of prenatal and mid-childhood PFAS exposure with lipids and alanine aminotransferase (ALT) levels in children. METHODS: We studied 682 mother-child pairs from a Boston-area pre-birth cohort. We quantified PFASs in maternal plasma collected in pregnancy (median 9...
November 17, 2017: Environment International
https://www.readbyqxmd.com/read/29156322/the-development-and-importance-of-shared-reality-in-the-domains-of-opinion-morality-and-religion
#17
REVIEW
Larisa Heiphetz
The importance of shared reality emerges early in human development. Infants and young children notice when others share their beliefs, and information about shared beliefs influences their social judgments. This article reviews recent research on the importance of shared beliefs in three domains that have been widely investigated over the past several years-opinions, moral views, and religious beliefs. I argue that shared religious beliefs appear especially influential and suggest several reasons why this might be the case, including the perceived link between religion and morality as well as the strong role that religious beliefs play in personal identity...
November 8, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29156240/mental-files-theory-of-mind-when-do-children-consider-agents-acquainted-with-different-object-identities
#18
Michael Huemer, Josef Perner, Brian Leahy
Mental files theory explains why children pass many perspective taking tasks like the false belief test around age 4 (Perner & Leahy, 2016). It also explains why older children struggle to understand that beliefs about an object depend on how one is acquainted with it (intensionality or aspectuality). If Heinz looks at an object that is both a die and an eraser, but cannot tell by looking that it is an eraser, he will not reach for it if he needs an eraser. Four- to 6-year olds find this difficult (Apperly & Robinson, 1998)...
November 16, 2017: Cognition
https://www.readbyqxmd.com/read/29156196/familial-myelodysplastic-syndrome-acute-myeloid-leukemia
#19
REVIEW
Jane E Churpek
A growing number of inherited genetic loci that contribute to myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) development in both children as well as adults are rapidly being identified. In recognition of the clinical impact of this emerging field, the World Health Organization, National Comprehensive Cancer Network, and European LeukemiaNet have all added consideration of inherited predisposition to MDS/AML classification and management. Study of these disorders is providing unique insight into the biology of both sporadic and familial MDS/AML...
December 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29156060/three-cases-of-associated-persistent-fetal-vasculature-and-ocular-coloboma-posterior-segment-dysgenesis
#20
Sudarshan Khokhar, Brijesh Takkar, Ganesh Pillay, Pradeep Venkatesh
The authors discuss the association of persistent fetal vasculature and ocular coloboma in three children. They explore the possibility of a cause-effect relationship between these disorders, and link them together as a broader posterior dysgenesis. [J Pediatr Ophthalmol Strabismus. 2017;54:e77-e80.].
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
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