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Guiyan Wang, Chao Wang, Man Qin
BACKGROUND/AIM: Complicated crown fractures are relatively common in children where the maintenance of the pulp is especially important in young permanent teeth. The aim of this study was to analyze the pulp prognosis of permanent teeth with complicated crown fractures treated with conservative pulp treatment in adolescents. MATERIAL AND METHODS: Complete dental records of teeth with complicated crown fractures treated with conservative pulp treatment were obtained...
February 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Simo Raiskila, Anna Axelin, Liis Toome, Sylvia Caballero, Bente Silnes Tandberg, Rosario Montirosso, Erik Normann, Boubou Hallberg, Björn Westrup, Uwe Ewald, Liisa Lehtonen
AIM: Little is known about the amount of physical parent-infant closeness in neonatal intensive care units (NICUs) and this study explored that issue in six European countries. METHODS: The parents of 328 preterm infants were recruited in 11 NICUs in Finland, Estonia, Sweden, Norway, Italy and Spain. They filled in daily diaries about how much time they spent in the NICU, in skin-to-skin contact (SSC) and holding their babies in the first two weeks of their hospitalisation...
February 24, 2017: Acta Paediatrica
Amandine Chauveau, Marie-Laure Dalphin, Frederic Mauny, Vincent Kaulek, Elisabeth Schmausser-Hechfellner, Harald Renz, Josef Riedler, Juha Pekkanen, Anne M Karvonen, Roger Lauener, Caroline Roduit, Dominique Angèle Vuitton, Erika von Mutius, Jean-Charles Dalphin
BACKGROUND: Accurate assessment of atopic sensitization is pivotal to clinical practice and research. Skin prick test (SPT) and specific IgE (sIgE) are often used interchangeably. Some studies have suggested a disagreement between these two methods, and little is known about their association with allergic diseases. The aims of our study were to evaluate agreement between SPT and sIgE, and to compare their association with allergic diseases in 10-year old children. METHODS: SPT, sIgE measurements and assessment of allergic diseases were performed in children aged 10 years old in the Protection against Allergy: STUdy of Rural Environment (PASTURE) cohort...
February 24, 2017: Allergy
Reinhold Feldmann, Eva Wolfgart, Josef Weglage, Frank Rutsch
AIM: Sapropterin causes reductions in blood phenylalanine concentrations in sensitive patients with phenylketonuria (PKU),. We examined whether the subsequent relaxation of dietary restrictions influenced the quality of life (QoL) of patients and parents. METHODS: The study cohort comprised 112 patients with PKU followed at the metabolic centre at Münster University Children's Hospital, Germany, from 2012 to 2015. A sapropterin response was defined as a ≥30% reduction in blood phenylalanine levels...
February 24, 2017: Acta Paediatrica
Cara Bohon
Understanding the neural response to food and food cues during early stages of weight gain in childhood may help us determine the drive processes involved in unhealthy eating behavior and risk for obesity. Healthy weight and overweight children ages 6-8 (N = 18; 10 with BMI between 5th and 85th %ile and 8 with BMI >85th %ile) underwent fMRI scans while anticipating and receiving tastes of chocolate milkshake. Parents completed a Children's Eating Behaviour Questionnaire. Results reveal greater response to milkshake taste receipt in overweight children in the right insula, operculum, precentral gyrus, and angular gyrus, and bilateral precuneus and posterior cingulate...
2017: PloS One
Francesco Gianfagna, Claudio Grippi, Wolfgang Ahrens, Mark E S Bailey, Claudia Börnhorst, Stefan De Henauw, Ronja Foraita, Anna C Koni, Vittorio Krogh, Staffan Mårild, Dénes Molnár, Luis Moreno, Yannis Pitsiladis, Paola Russo, Alfonso Siani, Michael Tornaritis, Toomas Veidebaum, Licia Iacoviello
BACKGROUND AND AIMS: Neuromedin U (NMU) is a hypothalamic neuropeptide with important roles in several metabolic processes, recently suggested as potential therapeutic target for obesity. We analysed the associations between NMU gene variants and haplotypes and body mass index (BMI) in a large sample of European children. METHODS AND RESULTS: From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52...
2017: PloS One
Jérémie F Cohen, Robert Cohen, Philippe Bidet, Annie Elbez, Corinne Levy, Patrick M Bossuyt, Martin Chalumeau
BACKGROUND: There is controversy whether physicians can rely on signs and symptoms to select children with pharyngitis who should undergo a rapid antigen detection test (RADT) for group A streptococcus (GAS). Our objective was to evaluate the efficiency of signs and symptoms in selectively testing children with pharyngitis. MATERIALS AND METHODS: In this multicenter, prospective, cross-sectional study, French primary care physicians collected clinical data and double throat swabs from 676 consecutive children with pharyngitis; the first swab was used for the RADT and the second was used for a throat culture (reference standard)...
2017: PloS One
Masaharu Tsubokura, Michio Murakami, Shuhei Nomura, Tomohiro Morita, Yoshitaka Nishikawa, Claire Leppold, Shigeaki Kato, Masahiro Kami
After the 2011 Fukushima Daiichi nuclear power plant accident, little information has been available on individual doses from external exposure among residents living in radioactively contaminated areas near the nuclear plant; in the present study we evaluated yearly changes in the doses from external exposure after the accident and the effects of decontamination on external exposure. This study considered all children less than 16 years of age in Soma City, Fukushima who participated in annual voluntary external exposure screening programs during the five years after the accident (n = 5,363)...
2017: PloS One
Benoit Visseaux, Gilles Collin, Houria Ichou, Charlotte Charpentier, Samia Bendhafer, Madalina Dumitrescu, Lahcene Allal, Bogdan Cojocaru, Luc Desfrère, Diane Descamps, Laurent Mandelbrot, Nadhira Houhou-Fidouh
BACKGROUND: To date, only influenza and RSV testing are recommended for respiratory viruses' detection in paediatric units. In this study, we described, according to seasons, ages and clinical units, the results obtained in children (<15 years old) by multiplex-PCR (mPCR) tests allowing a quick and wide range detection of all respiratory viruses. These results were also compared with RSV specific detection. METHODS: All nasopharyngeal mPCR and RSV tests requested by clinicians in our French teaching hospitals group between 2011 and 2014 were retrospectively included...
2017: PloS One
Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue, Hiroyuki Doi, Akira Eboshida, Ichiro Kawachi
Average maternal age at birth has been rising steadily in Western and some Asian countries. Older maternal age has been associated with adverse pregnancy and birth outcomes; however, studies on the relationship between maternal age and young children's health remain scarce. Therefore, we sought to investigate the association of maternal age with child health outcomes in the Japanese population. We analyzed data from two birth cohorts of the nationwide Japanese Longitudinal Survey of Babies in 21st Century (n2001 = 47,715 and n2010 = 38,554)...
2017: PloS One
Arwa Kurabi, Kerry A Beasley, Lisa Chang, James McCann, Kwang Pak, Allen F Ryan
Otitis media (OM) is the most common infectious disease of children under six, causing more antibiotic prescriptions and surgical procedures than any other pediatric condition. By screening a bacteriophage (phage) library genetically engineered to express random peptides on their surfaces, we discovered unique peptides that actively transport phage particles across the intact tympanic membrane (TM) and into the middle ear (ME). Herein our goals were to characterize the physiochemical peptide features that may underlie trans-TM phage transport; assess morphological and functional effects of phage peptides on the ME and inner ear (IE); and determine whether peptide-bearing phage transmigrate from the ME into the IE...
2017: PloS One
C Honoré, V Atallah, O Mir, D Orbach, G Ferron, C LePéchoux, J B Delhorme, P Philippe-Chomette, S Sarnacki, S Msika, P Terrier, O Glehen, H Martelli, V Minard-Colin, F Bertucci, J Y Blay, S Bonvalot, D Elias, A LeCesne, P Sargos
BACKGROUND: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare disease affecting predominantly children and young adults and for which the benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery (CCRS) remains unknown. METHODS: To identify patients with DSRCT without extraperitoneal metastases (EPM) who underwent CCRS between 1991 and 2015, a retrospective nation-wide survey was conducted by crossing the prospective and retrospective databases of the French Network for Rare Peritoneal Malignancies, French Reference Network in Sarcoma Pathology, French Sarcoma Clinical Network and French Pediatric Cancer Society...
2017: PloS One
Grace Wu, Alec Wollen, Stephen Himley, Glenn Austin, Jaclyn Delarosa, Rasa Izadnegahdar, Amy Sarah Ginsburg, Darin Zehrung
BACKGROUND: Continuous oxygen treatment is essential for managing children with hypoxemia, but access to oxygen in low-resource countries remains problematic. Given the high burden of pneumonia in these countries and the fact that flow can be gradually reduced as therapy progresses, oxygen conservation through routine titration warrants exploration. AIM: To determine the amount of oxygen saved via titration during oxygen therapy for children with hypoxemic pneumonia...
2017: PloS One
Sophie E R Horbach, Dirk T Ubbink, Fabienne E Stubenrouch, Mark J W Koelemay, Carine J M van der Vleuten, Bas H Verhoeven, Jim A Reekers, Leo J Schultze Kool, Chantal M A M van der Horst
BACKGROUND: In shared decision-making, clinicians and patients arrive at a joint treatment decision, by incorporating best available evidence and the patients' personal values and preferences. Little is known about the role of shared decision-making in managing patients with congenital vascular malformations, for which preference-sensitive decision-making seems obvious. The authors investigated preferences regarding decision-making and current shared decision-making behavior during physician-patient encounters...
March 2017: Plastic and Reconstructive Surgery
Geneviève Du Pont-Thibodeau, Sarah M Sanchez, Abbas F Jawad, Vinay M Nadkarni, Robert A Berg, Nicholas S Abend, Alexis A Topjian
OBJECTIVES: Determine the accuracy and confidence of critical care medicine providers to identify seizures using amplitude-integrated electroencephalography versus amplitude-integrated electroencephalography combined with color density spectral array electroencephalography (aEEG + CDSA). DESIGN: Tutorial and questionnaire. SETTING: PICU. SUBJECTS: Pediatric critical care providers (attendings, fellows, and nurses). INTERVENTIONS: A standardized powerpoint tutorial on amplitude-integrated electroencephalography and color density spectral array followed by classification of 100 amplitude-integrated electroencephalography images and 100 amplitude-integrated electroencephalography combined with color density spectral array as displaying seizures or not displaying seizures...
February 23, 2017: Pediatric Critical Care Medicine
Harald Prüss
PURPOSE OF REVIEW: Autoimmune encephalitis is an increasingly recognized neuropsychiatric condition seen in patients of all ages. Herpes virus infections of the brain can antedate the development of pathogenic autoantibodies against N-methyl-D-aspartate receptors and further neuronal surface proteins, leading to neuronal dysfunction and relapsing symptoms. This review will recapitulate the recent scientific progress, clinical manifestations in children and adults, therapeutic options, and etiological concepts on how autoimmunity develops...
February 22, 2017: Current Opinion in Neurology
Russell C Dale, Mark P Gorman, Ming Lim
PURPOSE OF REVIEW: Auto-antibodies that bind to conformational extracellular epitopes of neuronal receptors or synaptic proteins have provided clinicians with essential biomarkers in acute neurology. This review summarizes the current status and challenges in the field. RECENT FINDINGS: In children, anti-N-methyl-D-aspartate receptor encephalitis remains the most identifiable autoimmune encephalitis, although many patients have a clinical syndrome of brain inflammation in which no antibodies are identified...
February 22, 2017: Current Opinion in Neurology
Lauren J Luk, Melissa R Rotella, Leisa J Stillman, Sarah K Wise
PURPOSE OF REVIEW: To familiarize otolaryngologists and other practitioners with basic diagnosis and treatment of asthma in adults and children based on current literature. RECENT FINDINGS: Increased fractional excretion of nitrous oxide and sputum eosinophils have been identified in asthmatic patients being evaluated for chronic cough and appear to be more sensitive in diagnosis than traditional spirometry. Both sublingual and subcutaneous immunotherapy modalities are effective in decreasing symptoms and medication use in patients with allergic rhinitis and allergic asthma...
February 23, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
Hanan F Nazir, Mohamed Elshinawy, Abdulhakim AlRawas, Doaa Khater, Sherin Zadjaly, Yasser Wali
STUDY OBJECTIVE: To study dapsone in comparison with trimethoprim/sulfamethoxazole (TMP/SMX) for Pneumocystis jiroveci (PJP) prophylaxis in children with acute lymphoblastic leukemia (ALL). DESIGN: A retrospective study with a prospective follow-up. PATIENTS: Pediatric ALL patients diagnosed between May 2009 and May 2014, who are still receiving or have completed their maintenance chemotherapy. Patients who completed chemotherapy were prospectively followed up for neutropenia...
February 23, 2017: Journal of Pediatric Hematology/oncology
Savas Dedeoglu, Helen Bornaun
We evaluated the risk of pulmonary hypertension (PH) by measuring the velocity of the tricuspid regurgitation jet velocity (TRV) on echocardiography and the associations among the TRV, ferritin, and history of splenectomy in children with β thalassemia major (TM). In total, 85 children with TM were examined with continuous Doppler flow. Patients with an abnormal TRV (>2.5 m/s) were grouped into those with a TRV of 2.5 to 2.9 m/s and TRV>2.9 m/s. A TRV of >2.5 m/s was identified in 72; 31 (36%) of these patients had a TRV of >2...
February 23, 2017: Journal of Pediatric Hematology/oncology
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