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Mostefa Moubri, Christophe Burucoa, Nicolas Kalach, R Rezki Larras, Nouria Nouar, Fawsia Mouffok, Zakia Arrada
We aimed to evaluate in an Algerian pediatric population the diagnostic performances of the IDEIA HpStAR noninvasive stool antigen test (Oxoid, Cambridge, UK) to detect Helicobacter pylori infection before and after eradication therapy. A prospective study including 158 symptomatic Algerian children was conducted. Patients were initially diagnosed with invasive (culture, histology, and rapid urease test) and noninvasive tests (urea breath test and IDEIA HpStAR test). Infected patients were treated, and 101 were controlled after treatment with two invasive (culture and histology) and two noninvasive tests (urea breath test and IDEIA HpStAR test)...
July 10, 2018: Journal of Tropical Pediatrics
Fatemeh Suri, Shahin Yazdani, Marjan Chapi, Iman Safari, Paniz Rasooli, Narsis Daftarian, Mohammad Reza Jafarinasab, Saghar Ghasemi Firouzabadi, Elham Alehabib, Hossein Darvish, Brandy Klotzle, Jian-Bing Fan, Casey Turk, Elahe Elahi
Primary angle closure glaucoma (PACG) is a common form of glaucoma in the Far East. Its defining feature is iridocorneal angle closure. In addition to PACG, indications of angle closure are included in the diagnostic criteria of related conditions primary angle closure suspect (PACS) and primary angle closure (PAC). To the best of our knowledge, a causative gene for iridocorneal angle closure in humans has not been identified. This study aimed to identify the genetic cause of iridocorneal angle closure in a pedigree with at least ten individuals diagnosed with PACS, PAC or PACG...
July 11, 2018: Human Molecular Genetics
Sanne A A de Laat, Anja C Huizink, Michel H Hof, Tanja G M Vrijkotte
Background: Socioeconomically disadvantaged children often have psychosocial problems. This study examined the mediating role of maternal depressive symptoms during pregnancy, infancy and early childhood in the association between maternal education, as indicator of socioeconomic status (SES), and child's psychosocial problems. Methods: Included were 3410 children from the Amsterdam Born Children and their Development (ABCD) study. To assess the child's psychosocial problems at age 5-6 years, mothers and teachers completed the Strengths and Difficulties Questionnaire (SDQ)...
July 10, 2018: European Journal of Public Health
Meital Zur, Racheli Magnezi, Shirley Portuguese, Inbal Reuveni, Ron Kedem, Eyal Fruchter
Introduction: Attention deficit hyperactive disorder (ADHD) is prevalent in 5.9-7.1% of children and adolescents, and 5% of adults. It results in poor academic, occupational, and social functioning. Pharmacotherapy improves core symptoms; however, average adherence levels are low and decrease at 16-17 years of age, just before the recruitment age to Israel Defense Forces (IDF). This study evaluated the effect of adherence to ADHD pharmacotherapy on occupational performance among soldiers...
July 11, 2018: Military Medicine
Yunjian Zhang, Shuizhen Zhou, Yuanfeng Zhou, Lifei Yu, Linmei Zhang, Yi Wang
OBJECTIVE: The aim of this study was to investigate the characteristics and composition of intestinal microbiota in children with refractory epilepsy after ketogenic diet (KD) therapy and to explore the bacterial biomarkers related to clinical efficacy. METHODS: We prospectively analyzed 20 patients (14 males, 6 females) treated with KD. Clinical efficacy, electroencephalogram (EEG) changes, and laboratory tests were evaluated, and fecal specimens were obtained prior to and 6 months after therapy...
June 28, 2018: Epilepsy Research
Achilleas Attilakos, Argirios Dinopoulos, Maria Paschalidou, Maria Tsirouda, Maria Karalexi, Alexia Prasouli, Anastasia Garoufi
Studies evaluating the effect of Levetiracetam (LEV) on haematological parameters in patients with epilepsy are very limited. Short-term effects on haematological parameters in children with epilepsy, at 2 and 6 months of LEV treatment, have been previously reported in the literature. Purpose of the current study was to further investigate the long-term changes on haematological parameters in children with epilepsy during LEV monotherapy. White blood cell, neutrophils, lymphocytes, monocytes, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and platelets were measured in 20 children (11 females, mean age 6,5 ± 4,4 years, range 2-15 years) with epilepsy, before and after 12 months of LEV monotherapy...
July 6, 2018: Epilepsy Research
María B Sánchez, Ian Loram, Paul Holmes, John Darby, Penelope B Butler
BACKGROUND: Physical therapy evaluations of motor control are currently based on subjective clinical assessments. Despite validation, these can still be inconsistent between therapists and between clinics, compromising the process of validating a therapeutic intervention and the subsequent generation of evidence-based practice (EBP) guidelines. EBP benefits from well-defined objective measurements that complement existing subjective assessments. RESEARCH QUESTION: The aim of this study was to develop an objective measure of head/trunk control in children with Cerebral Palsy (CP) using previously developed video-based methods of head/trunk alignment and absence of external support and compare these with the existing subjective Segmental Assessment of Trunk Control (SATCo)...
June 30, 2018: Gait & Posture
Annika Norell-Clarke, Curt Hagquist
PURPOSE: To investigate the association between sleep duration, sleep initiation difficulties and psychological and somatic complaints. METHODS: We used three cohorts of cross-sectional Swedish questionnaire data, from the Health Behaviours of School aged Children (1985/1986, 2005/2006, 2013/2014, n=>18 000, aged 11-15). Specific complaints (e.g. pain) and total complaint load were used as outcomes of sleep duration, sleep initiation difficulties and the combination of them both...
July 11, 2018: Journal of Adolescence
Joanna Zawitkowska, Monika Lejman, Agnieszka Zaucha-Prażmo, Katarzyna Drabko, Marcin Płonowski, Joanna Bulsa, Michał Romiszewski, Agnieszka Mizia-Malarz, Andrzej Kołtan, Katarzyna Derwich, Grażyna Karolczyk, Tomasz Ociepa, Magdalena Ćwiklińska, Joanna Trelińska, Joanna Owoc-Lempach, Maciej Niedźwiecki, Aleksandra Kiermasz, Jerzy Kowalczyk
OBJECTIVE: The aim of this study was to analyse the clinical characteristics and outcome of children diagnosed with Ph+ ALL. MATERIAL AND METHODS: A total of 2591 newly diagnosed ALL children were treated in Poland between the years 2005-2017. Of those, 44 were diagnosed with Ph(+) ALL. The patients were treated according to protocols: ALL IC - BFM 2002 and 2009 (26 patients), EsPhALL (12 patients), initially ALL IC - BFM and then EsPhALL (6 patients). RESULTS: The median of follow up in the observed group was 3 years...
July 14, 2018: European Journal of Haematology
Yvonne Rosalie Elisabeth Skogsdal, Jan Åke Karlsson, Yang Cao, Helena Elisabeth Fadl, Tanja Adele Tydén
INTRODUCTION: Limited attention has been paid to the use of contraception in relation to women's family planning intentions. The aim of this study was to investigate the use of contraception during the most recent intercourse as well as the reproductive intentions of Swedish speaking women requesting contraceptive counseling. MATERIAL AND METHODS: A cross-sectional baseline survey in a randomized controlled trial regarding reproductive life planning (before randomization)...
July 14, 2018: Acta Obstetricia et Gynecologica Scandinavica
Yap Quin Jean, Rafidah Mazlan, Mahadir Ahmad, Nashrah Maamor
Purpose: The aim of this study was to develop a substantive theory that explains parenting stress among mothers of deaf or hard-of-hearing (D/HH) children. Method: Fifteen hearing mothers of children with severe-to-profound sensorineural hearing loss were interviewed. Interviews were transcribed verbatim, and a grounded theory approach was used to inductively analyze parental stress in mothers of D/HH children. Theory generation was achieved through triangulation of data sources and systematic organization of data into codes...
July 13, 2018: American Journal of Audiology
Corinna L Schultz, Melissa A Alderfer
BACKGROUND: Management of pediatric cancer entails frequent laboratory and radiology testing to monitor response to treatment, side effects, and possible relapse of disease. Little is known about how caregivers of children with cancer would like to receive results of these tests and whether on-line patient portals may meet those preferences. PROCEDURES: One-on-one semistructured interviews were conducted with 19 caregivers of children with cancer purposively sampled for breadth on demographic characteristics...
July 14, 2018: Pediatric Blood & Cancer
Bingbing Zhu, Ruifeng Zhang, Huandan Yang, Tingting Yuan, Juan Lv, Qianqian Peng, Lijun Tian
BACKGROUND: The association between gene polymorphisms and the risk of primary nephrotic syndrome (PNS) is uncovering recently. This study aims to investigate the relationship between single nucleotide polymorphisms (SNPs) on HLA-DQA1 gene and the risk of PNS. METHODS: In this study, we genotyped eight single nucleotide polymorphisms (SNPs) in the HLA-DQA1 gene in 501 PNS patients and 532 healthy people in Chinese population. Then we analyzed associations of these SNPs with the clinical features in primary nephrotic syndrome of children in Chinese population...
July 13, 2018: Journal of Clinical Laboratory Analysis
Ole Jakob Storebø, Erlend Faltinsen, Morris Zwi, Erik Simonsen, Christian Gluud
Much remains unclear about the benefits and harms of methylphenidate for children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Between 2012 and 2018, we conducted two Cochrane systematic reviews on methylphenidate for ADHD. This article explores the main findings in relation to evidence-based practice and our current understanding of ADHD.
July 13, 2018: Clinical Pharmacology and Therapeutics
Adel C Najdowski, Megan St Clair, Jesse A Fullen, Amelia Child, Angela Persicke, Jonathan Tarbox
We observed three children with autism spectrum disorder during structured play dates in which play partners displayed interest or disinterest in the toys with which they were playing. We then taught subjects to identify play partners' preferences and to make appropriate toy offers using a multiple-exemplar training package consisting of rules, midplay preference questions, prompting, and praise with observed generalization across untrained partners.
July 13, 2018: Journal of Applied Behavior Analysis
Arwa Mohammad Hassan, Nessma Mohamed Ahmed Farghal, Doaa Salah Hegab, Wesam Salah Mohamed, Hend Hassan Abd-Elnabi
Juvenile systemic lupus erythematosus (jSLE) is a multisystem autoimmune disease of unpredicted course and prognosis. Rates of organ involvement in SLE are higher in children, and overt lupus nephropathy is more often a presenting manifestation of SLE in children than adults. Inflammatory soluble chemokine CXC motif-ligand 16 (sCXCL16) is an important pathogenic mediator in inflammatory diseases as SLE. Herein, we aimed to evaluate serum level of sCXCL16 in jSLE patients in comparison to healthy controls and to correlate it with disease activity and extent of cutaneous and renal affection, to detect its possible role in disease pathogenesis...
July 13, 2018: Clinical Rheumatology
Torsak Tippairote, Piya Temviriyanukul, Wenika Benjapong, Dunyaporn Trachootham
Toxic element exposure increases risk of neurodevelopmental disorders. However, hair element profiles of well-nourished urban resident children were largely unknown. We identified prevalence and the contributing factors of high hair aluminum (Al), arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) levels in 111 Thai children (aged 3-7 years old). Most participants were well-nourished with high socioeconomic status. Since ROC curve of hair element data showed inadequate sensitivity for cutoff set-up, US reference hair levels were used to categorize high and low level groups...
July 13, 2018: Biological Trace Element Research
Ruchi Amin, Alfonso M Martinez, Marjorie J Arca
BACKGROUND: Gastric antral webs are mucosal structures, varying from fenestrated diaphragms to mucosal crescents, resulting in varying degrees of foregut obstruction. Patients commonly present with vomiting, failure to thrive, and abdominal pain. Prevalence is unknown, and diagnosis can be difficult. METHODS: We performed an IRB-approved retrospective review of patients from 4/1/2015-4/1/2018 at a Level I Children's Surgery Center undergoing gastric antral web resection...
July 13, 2018: Surgical Endoscopy
Maria Escolino, Giovanna Riccipetitoni, Atsuyuki Yamataka, Imran Mushtaq, Go Miyano, Paolo Caione, Fabio Chiarenza, Peter Borzi, Ciro Esposito
BACKGROUND: Very limited informations are currently available about the best approach to perform retroperitoneoscopic surgery. This multicentric international study aimed to compare the outcome of lateral versus prone approach for retroperitoneoscopic partial nephrectomy (RPN) in children. METHODS: The records of 164 patients underwent RPN in 7 international centers of pediatric surgery over the last 5 years were retrospectively reviewed. Sixty-one patients (42 girls and 19 boys, average age 3...
July 13, 2018: Surgical Endoscopy
Clara Crespillo-Andújar, Emmanuele Venanzi-Rullo, Rogelio López-Vélez, Begoña Monge-Maillo, Francesca Norman, Ana López-Polín, José A Pérez-Molina
INTRODUCTION: Benznidazole is the preferred drug for treatment of Chagas disease. However, it is toxic and of limited value in chronic infection. OBJECTIVE: We aimed to estimate the rates of and factors related to adverse reactions (ARs) to benznidazole and treatment discontinuations (TDs). METHODS: A meta-analysis was performed using an electronic search of the published literature with no language restrictions until June 2017. Prospective studies were included of chronically infected patients in which at least one treatment arm included benznidazole...
July 13, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
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