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https://www.readbyqxmd.com/read/29471574/-type-2-diabetes-diabetes-in-older-adults-example-for-patient-centered-drug-therapy
#1
Dirk Müller-Wieland
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471055/brain-insulin-signalling-glucose-metabolism-and-females-reproductive-aging-a-dangerous-triad-in-alzheimer-s-disease
#2
REVIEW
A I Duarte, M S Santos, C R Oliveira, P I Moreira
Alzheimer's disease (AD) constitutes a major socioeconomic challenge due to its disabling features and the rise in prevalence (especially among (peri)menopausal women and type 2 diabetes patients). The precise etiopathogenesis of AD remains poorly understood. Importantly, its neurodegenerative perspective has been challenged towards a more "systemic" view. Amyloid-β (Aβ) and hyperphosphorylated Tau protein (P-Tau) (the main AD neuropathological features) affect and are affected by peripheral and brain insulin signalling dysfunction, leading to glucose dysmetabolism, synaptic loss and AD-related cognitive deficits...
February 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29468896/real-world-evaluation-of-hba1c-blood-pressure-and-weight-loss-among-patients-with-type-2-diabetes-mellitus-treated-with-canagliflozin-an-analysis-of-electronic-medical-records-from-a-network-of-hospitals-in-florida
#3
Damon Tanton, Mei Sheng Duh, Marie-Hélène Lafeuille, Patrick Lefebvre, Dominic Pilon, Maryia Zhdanava, Bruno Emond, Doreen Inman, Robert A Bailey
OBJECTIVE: Clinical trials and real-world studies reported that canagliflozin (CANA) improved HbA1c, blood pressure (BP), and weight in patients with type 2 diabetes mellitus (T2DM). This study examines if previous results hold regionally and within specific patient subgroups. METHODS: Adults with T2DM and ≥12 months of clinical activity before the first CANA prescription (index) were identified in electronic medical records (01/01/2012-02/15/2017) from a network of hospitals in Florida...
February 22, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29468528/the-influence-of-pharmacist-led-adherence-support-on-glycaemic-control-in-people-with-type-2-diabetes
#4
Mangesh Kharjul, Rhiannon Braund, James Green
Background Adherence to treatment is important to achieve target outcomes, particularly for those with type 2 diabetes. Pharmacists are well placed to enhance adherence, however evidence of the impact on clinical outcomes is not well known. Objective To determine the impact of an adherence support service on adherence scores and subsequent clinical biomarkers (HbA1c). Setting Community pharmacies providing a Medicines Use Review (MUR) Service in a New Zealand locality. Methods Records of patients receiving MURs between 2007 and 2012 were obtained from a single locality...
February 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29468360/bariatric-surgery-coverage-a-comprehensive-budget-impact-analysis-from-a-payer-perspective
#5
Swetha R Palli, John A Rizzo, Natalie Heidrich
OBJECTIVE: The objective of this study was to estimate a payer's budget impact of bariatric surgery coverage under (1) unrestricted, (2) budget-restricted ($500,000/year), and (3) quantity-restricted (100/year) medical benefit plan scenarios versus non-coverage in general and type 2 diabetes mellitus (T2DM) populations over a 10-year period. METHODS: Using recently published literature and health technology assessment reports, the model evaluated a hypothetical payer population of 100,000 members under current real-world trends: BMI-defined obesity groups (31...
February 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29466797/a-prospective-cohort-study-in-patients-with-type-2-diabetes-mellitus-for-validation-of-biomarkers-provalid-study-design-and-baseline-characteristics
#6
Susanne Eder, Johannes Leierer, Julia Kerschbaum, Laszlo Rosivall, Andrzej Wiecek, Dick de Zeeuw, Patrick B Mark, Georg Heinze, Peter Rossing, Hiddo L Heerspink, Gert Mayer
BACKGROUND/AIMS: The prevalence of diabetes mellitus type 2 and kidney disease in these patients varies widely between European countries. METHODS: In addition to store bio-samples the "Prospective cohort study in patients with type 2 diabetes mellitus for validation of biomarkers" collects information on history, physical status, laboratory measurements and medication in 4000 patients with diabetes mellitus type 2, being taken care of at the primary level of healthcare in 5 European countries (Austria, Hungary, Netherlands, Poland and Scotland)...
February 16, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29465545/metformin-reduces-the-risk-of-cancer-in-patients-with-type-2-diabetes-an-analysis-based-on-the-korean-national-diabetes-program-cohort
#7
Hae Jin Kim, SooJin Lee, Ki Hong Chun, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Young Seol Kim, Jeong-Taek Woo, Moon-Suk Nam, Sei Hyun Baik, Kyu Jeung Ahn, Kwan Woo Lee
The epidemiological literature suggests that insulin resistance, hyperinsulinemia, and increased levels of insulin-like growth factors place patients with type 2 diabetes mellitus (T2DM) at greater risk of cancer. The association between cancer incidence and the use of antidiabetic medications in patients with T2DM has been recently examined. There have been conflicting reports regarding an association between metformin and cancer risk. The aim of this study was to investigate the relationship between metformin use and the incidence of cancer in Koreans with T2DM...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29463488/digital-health-interventions-for-adults-with-type-2-diabetes-qualitative-study-of-patient-perspectives-on-diabetes-self-management-education-and-support
#8
Kingshuk Pal, Charlotte Dack, Jamie Ross, Susan Michie, Carl May, Fiona Stevenson, Andrew Farmer, Lucy Yardley, Maria Barnard, Elizabeth Murray
BACKGROUND: The prevalence of type 2 diabetes is increasing globally, and health services in many countries are struggling with the morbidity, mortality, and costs associated with the complications of this long-term condition. Diabetes self-management education (DSME) and behavioral support can reduce the risks of developing diabetes-related complications and improve glycemic control. However, their uptake is low. Digital health interventions (DHI) can provide sustained support and may overcome challenges associated with attending diabetes self-management sessions...
January 29, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29463450/glucagon-like-peptide-1-receptor-agonists-and-cardiovascular-events-class-effects-versus-individual-patterns
#9
REVIEW
Soo Lim, Kyoung Min Kim, Michael A Nauck
Several new glucose-lowering medications have been approved, such as dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and sodium glucose cotransporter-2 inhibitors. Among GLP-1RAs, lixisenatide, a short-acting drug, did not show cardiovascular (CV) benefits in patients with Type 2 diabetes mellitus (T2D) and acute coronary syndrome. Extended-release exenatide was also not significantly better for CV outcomes. By contrast, once daily liraglutide and once weekly semaglutide, both long-acting GLP-1RAs, decreased the incidence of major adverse CV events and mortality...
February 17, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29462347/long-term-quality-of-care-score-predicts-incident-chronic-kidney-disease-in-patients-with-type-2-diabetes
#10
Pi-I Li, Jian-Nan Wang, How-Ran Guo
Background: Chronic kidney disease (CKD) is a common complication of diabetes, and requires long-term medical care. However, besides the blood glucose level, no reliable method is currently available to link the quality of care and the development of CKD. We therefore developed a long-term quality-of-care score for predicting the occurrence of CKD in patients with type 2 diabetes. Methods: In this retrospective cohort study, using Taiwan's Longitudinal Cohort of Diabetes Patients Database and the medical records in a medical center, we identified incident patients with type 2 diabetes during 1999-2003 and followed them until 2011...
February 15, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29460977/development-of-a-screening-tool-using-electronic-health-records-for-undiagnosed-type-2-diabetes-mellitus-and-impaired-fasting-glucose-detection-in-the-slovenian-population
#11
G Štiglic, P Kocbek, L Cilar, N Fijačko, A Stožer, J Zaletel, A Sheikh, P Povalej Bržan
AIM: To develop and validate a simplified screening test for undiagnosed Type 2 diabetes mellitus and impaired fasting glucose for the Slovenian population (SloRisk) to be used in the general population. METHODS: Data on 11 391 people were collected from the electronic health records of comprehensive medical examinations in five Slovenian healthcare centres. Fasting plasma glucose as well as information related to the Finnish Diabetes Risk Score questionnaire, FINDRISC, were collected for 2073 people to build predictive models...
February 20, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29460164/assessing-the-risk-of-type-2-diabetes-mellitus-among-children-and-adolescents-with-psychiatric-disorders-treated-with-atypical-antipsychotics-a-population-based-nested-case-control-study
#12
Hankil Lee, Dong-Ho Song, Jin-Won Kwon, Euna Han, Min-Jung Chang, Hye-Young Kang
To examine the associations between atypical antipsychotic (AAP) exposure and the development of type 2 diabetes mellitus (T2DM) in Korean pediatric patients with psychiatric disorders, we conducted a nested case-control study using the claims data of the National Health Insurance system of Korea between 2010 and 2014. A cohort of patients with psychiatric disorders was identified, and enrollment was taken as the date of the first psychiatric diagnosis. Cases involved patients with a diagnosis of T2DM or prescriptions for glucose lowering drugs after enrollment, and the identification of T2DM was defined as the index date...
February 19, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29460080/heterogeneity-of-gestational-diabetes-gdm-and-long-term-risk-of-diabetes-and-metabolic-syndrome-findings-from-the-radiel-study-follow-up
#13
Emilia Huvinen, Johan G Eriksson, Saila B Koivusalo, Nora Grotenfelt, Aila Tiitinen, Beata Stach-Lempinen, Kristiina Rönö
AIMS: To assess the metabolic health of obese and non-obese women at high GDM risk 5 years postpartum. METHODS: This is a secondary analysis of the 5-year follow-up of the RADIEL GDM prevention study including 333 women at high GDM risk (BMI ≥ 30 kg/m2 and/or previous GDM). Five years postpartum metabolic health was assessed including anthropometric measurements, oral glucose tolerance test, lipid metabolism, and body composition as well as medical history questionnaires...
February 19, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29459599/erythrocyte-glucose-6-phosphate-dehydrogenase-level-in-type-2-diabetes-male
#14
A Khanam, Q S Akter, F Karim, M R Zannat
The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. There is also significant increase in the prevalence of erythrocyte glucose-6-phosphate dehydrogenase (eG6PD) deficiency in the men with longer duration of diabetes mellitus. To assess the eG6PD in type 2 diabetes male subjects to observe their enzyme status. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2011 to December 2011...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29458073/establishment-and-validation-of-a-prediction-model-for-ischemic-stroke-risks-in-patients-with-type-2-diabetes
#15
Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
AIMS: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors. METHODS: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio...
February 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29457866/epigenetic-effects-of-metformin-from-molecular-mechanisms-to-clinical-implications
#16
REVIEW
S C Bridgeman, G C Ellison, P E Melton, P Newsholme, Cds Mamotte
There is a growing body of evidence that links epigenetic modifications to type 2 diabetes. Researchers have more recently investigated effects of commonly used medications, including those prescribed for diabetes, on epigenetic processes. This work reviews the influence of the widely used antidiabetic drug metformin on epigenomics, microRNA levels and subsequent gene expression and potential clinical implications. Metformin may influence the activity of numerous epigenetic modifying enzymes, mostly via modulating the activation of AMP-activated protein kinase (AMPK)...
February 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29456958/etiology-of-noise-induced-hearing-loss-nihl-and-its-symptomatic-correlation-with-audiometry-observations-in-type-ii-diabetes
#17
Meena K Yadav, K S Yadav
Type II diabetic mellitus (DM) is a chronic metabolic disease that impairs normal insulin production and glucose transport to the liver and muscles. In the India, about 1-5% population suffer from diabetes or related complication. So there is need to cure this disease. DM chronic auditory complications may include spiral ganglia atrophy, degeneration of the vestibulocochlear nerve myelin sheath, reduction of the number of spiral lamina nerve fibres, and thickening of the capillary walls of the stria vascularis and small arteries...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456430/effect-of-medical-nutrition-therapy-for-patients-with-type-2-diabetes-in-a-low-no-cost-clinic-a-propensity-score-matched-cohort-study
#18
Mark D Agee, Zane Gates, Patrick M Irwin
Background: Although many studies have been conducted regarding the effectiveness of medical nutrition therapy (MNT) for type 2 diabetes management, less is known about the effectiveness of MNT for low-income adults. This study evaluated the contribution of MNT in improving A1C and blood pressure in a population of low-income adults with type 2 diabetes. Methods: This was a population-based, propensity score-matched cohort study using provincial health data from Altoona, Blair County, Pa...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456372/drug-drug-interaction-related-uncontrolled-glycemia
#19
Mohamed Anwar Hammad, Balamurugan Tangiisuran, Abeer Mohamed Kharshid, Noorizan Abdul-Aziz, Yahaya Hassan, Nor Azizah Aziz, Tarek Mohamed Elsayed
Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited. Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes. Settings and Design: A cross-sectional study was conducted in Penang General Hospital. Methods: A computerized system for DDI checking was used to assess the severity and mechanism of DDIs...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456306/chronic-periodontitis-among-diabetics-and-nondiabetics-aged-35-65-years-in-a-rural-block-in-vellore-tamil-nadu-a-cross-sectional-study
#20
Khushboo Yamima Nand, Anu Mary Oommen, Rabin Kurudamannil Chacko, Vinod Joseph Abraham
Background: Chronic periodontitis is a common cause of poor oral health globally. Those at higher risk of this preventable and easily treatable condition need to be identified so that efforts can be taken to decrease disease burden and subsequent consequences. Aims: The aims of the study were (1) To compare the prevalence of chronic periodontitis among individuals with and without type 2 diabetes, aged 35-65 years from a rural block in Vellore, Tamil Nadu and (2) to assess risk factors for chronic periodontitis among individuals with diabetes...
July 2017: Journal of Indian Society of Periodontology
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