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https://www.readbyqxmd.com/read/29676539/past-and-current-status-of-adult-type-2-diabetes-mellitus-management-in-korea-a-national-health-insurance-service-database-analysis
#1
REVIEW
Seung Hyun Ko, Kyungdo Han, Yong Ho Lee, Junghyun Noh, Cheol Young Park, Dae Jung Kim, Chang Hee Jung, Ki Up Lee, Kyung Soo Ko
Korea's National Healthcare Program, the National Health Insurance Service (NHIS), a government-affiliated agency under the Korean Ministry of Health and Welfare, covers the entire Korean population. The NHIS supervises all medical services in Korea and establishes a systematic National Health Information database (DB). A health information DB system including all of the claims, medications, death information, and health check-ups, both in the general population and in patients with various diseases, is not common worldwide...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29673847/challenges-in-the-management-of-type-2-diabetes-among-native-women-in-the-united-arab-emirates
#2
Walaa Abuelmagd, Bachar Afandi, Helle Håkonsen, Seham Khmidi, Else-Lydia Toverud
AIM: To investigate type 2 diabetes mellitus (T2DM) management in native female patients in the United Arab Emirates (UAE). METHODS: Ninety women from the outpatient diabetes clinic at Tawam Hospital, UAE, were interviewed face-to-face using a structured questionnaire. Glycated hemoglobin (HbA1c), blood pressure, lipid panel, weight and body mass index (BMI) were extracted from medical records. RESULTS: Mean age was 57.5 (SD:12.7) years. Forty-five participants (50...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#3
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29672567/costs-and-effectiveness-of-pharmacist-led-group-medical-visits-for-type-2-diabetes-a-multi-center-randomized-controlled-trial
#4
Wen-Chih Wu, Tracey H Taveira, Sean Jeffery, Lan Jiang, Lisa Tokuda, Joanna Musial, Lisa B Cohen, Fred Uhrle
OBJECTIVES: The effectiveness and costs associated with addition of pharmacist-led group medical visits to standard care for patients with Type-2 Diabetes Mellitus (T2DM) is unknown. METHODS: Randomized-controlled-trial in three US Veteran Health Administration (VHA) Hospitals, where 250 patients with T2DM, HbA1c >7% and either hypertension, active smoking or hyperlipidemia were randomized to either (1) addition of pharmacist-led group-medical-visits or (2) standard care alone for 13 months...
2018: PloS One
https://www.readbyqxmd.com/read/29671627/the-impact-of-non-medical-switch-on-type-2-diabetes-patients-treated-with-canagliflozin-in-the-commercially-insured-us-population
#5
Lawrence Blonde, Chakkarin Burudpakdee, Victoria Divino, Brahim Bookhart, Jennifer Cai, Michael Pfeifer, Craig I Coleman
OBJECTIVE: To assess the impact of non-medical switch (NMS) from canagliflozin on antihyperglycemic agent (AHA) medication taking behavior. METHODS: This retrospective real-world database analysis included patients with type 2 diabetes with a prescription claim for canagliflozin between 8/2015 and 1/2016 using administrative claims and longitudinal prescription data. Patients with NMS from canagliflozin were identified as those with discontinuation or switch of canagliflozin and enrolled in a pharmacy benefit manager that removed CANA from formulary in 2016...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29670330/the-efficacy-and-safety-of-ginkgo-biloba-extract-as-an-adjuvant-in-type-2-diabetes-mellitus-patients-ineffectively-managed-with-metformin-a-double-blind-randomized-placebo-controlled-trial
#6
Tavga Ahmed Aziz, Saad Abdulrahman Hussain, Taha Othman Mahwi, Zheen Aorahman Ahmed, Heshu Sulaiman Rahman, Abdullah Rasedee
Background and aim: Type 2 diabetes mellitus (T2DM) is one of the major diseases confronting the health care systems. In diabetes mellitus (DM), combined use of oral hypoglycemic medications has been shown to be more effective than metformin (Met) alone in glycemic control. This study determined the effects of Ginkgo biloba (GKB) extract as an adjuvant to Met in patients with uncontrolled T2DM. Subjects and methods: Sixty T2DM patients were recruited in a randomized, placebo-controlled, double-blinded, and multicenter trial...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29669452/association-between-provider-specialty-and-healthcare-costs-and-glycemic-control-for-patients-with-diabetes
#7
Max Gill, Harmeet Chhabra, Mona Shah, Cyrus Zhu, Howard Lando, Felice Caldarella
AIMS: To analyze the association between provider, healthcare costs, and glycemic control for patients with diabetes mellitus (DM). MATERIALS AND METHODS: This cross-sectional study identified adults with type 1 or 2 DM (T1D, T2D) in the Optum database. The main independent variable was provider (endocrinologist or primary care). Regression analysis compared total medical and pharmacy costs, adjusting for health status and other patient differences, by provider...
April 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#8
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29666753/effect-of-metformin-monotherapy-on-serum-lipid-profile-in-statin-na%C3%A3-ve-individuals-with-newly-diagnosed-type-2-diabetes-mellitus-a-cohort-study
#9
Szu Han Lin, Po Chung Cheng, Shih Te Tu, Shang Ren Hsu, Yun Chung Cheng, Yu Hsiu Liu
Background: Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark United Kingdom Prospective Diabetes Study has shown that metformin therapy reduces cardiovascular events in overweight people with T2DM. This study investigates the effect of metformin monotherapy on serum lipid profile in statin-naïve individuals with newly diagnosed T2DM, and whether the effect, if any, is dosage-related...
2018: PeerJ
https://www.readbyqxmd.com/read/29666033/antidiabetics-usage-in-type-2-diabetes-mellitus-are-prescribing-guidelines-adhered-to-a-single-centre-study
#10
Viviane Khalil, Christy Sajan, Tiffany Tsai, David Ma
AIM: The primary aim of this study was to examine the prescribing patterns of antidiabetic agents (AA) in this hospital according to current prescribing contraindications (PCI). The secondary aims are to assess factors affecting the prescribing of AA and to evaluate the pharmacist impact on their prescribing. METHOD: A retrospective cross sectional study was performed to review all prescribed AA over a 3 month period. Data extracted from medical records included: patients' demographics, management and pharmacists' interventions...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29665986/prevention-and-treatment-of-type-2-diabetes-a-pathophysiological-based-approach
#11
REVIEW
Dorit Samocha-Bonet, Sophie Debs, Jerry R Greenfield
Prediabetes affects approximately 40% of American adults. Randomized trials report that a proportion of individuals with prediabetes develop diabetes despite caloric restriction, physical activity, and/or when treated with metformin, the first-line medication for patients with type 2 diabetes mellitus (T2DM). Currently, there are no valid predictors of the effectiveness of these measures in determining who will and who will not progress to the T2DM state. Few studies have examined the clinical and phenotypic predictors of better and worse glycemic response to lifestyle interventions and metformin in prediabetes and diabetes...
April 14, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29663292/the-potential-role-of-sglt2-inhibitors-in-the-treatment-of-type-1-diabetes-mellitus
#12
Hadi Fattah, Volker Vallon
Type 1 diabetes mellitus is a difficult disease to treat due to the relative paucity of therapeutic options other than injectable insulin. The latter, however, can induce hypoglycemia, which has been linked to enhanced cardiovascular risk. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-hyperglycemic medications that do not increase the hypoglycemia risk and are US Food and Drug Administration (FDA) approved in type 2 diabetes mellitus. SGLT2 inhibitors may also be of benefit in type 1 diabetic patients, in addition to insulin, although they have not yet been approved for this indication...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29663262/characteristics-treatment-patterns-and-economic-outcomes-of-patients-initiating-injectable-medications-for-management-of-type-2-diabetes-mellitus-in-japan-results-from-a-retrospective-claims-database-analysis
#13
Shuichi Suzuki, Urvi Desai, Alena Strizek, Jasmina Ivanova, Viviana Garcia-Horton, Zhihong Cai, Luke Schmerold, Xinyue Liu, Magaly Perez-Nieves
INTRODUCTION: This study's objective was to describe characteristics, treatment patterns, and economic outcomes of type 2 diabetes mellitus (T2DM) patients initiating injectable antidiabetic medications in Japan. METHODS: Adults (≥ 18 years) with T2DM, ≥ 2 claims for injectable antidiabetics between 1 August 2011 and 31 July 2015 (first claim = index date), no evidence of type 1 diabetes mellitus, ≤ 1 claim for insulin, no claims for GLP-1RA before index, and continuous enrollment for 6 months before (baseline) and 12 months after index (follow-up) were selected from the Japan Medical Center Database...
April 16, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29661173/predictors-of-elevated-capillary-blood-glucose-in-overweight-railway-french-employees-a-cross-sectional-analysis
#14
Emminarie Luisiana Lucas Garcia, David Debensason, Loïc Capron, Antoine Flahault, Jeanine Pommier
BACKGROUND: Hyperglycaemia is a risk factor of cardiovascular disease and a high risk state for progression to type 2 diabetes. Moreover, overweight, defined as a body mass index (BMI) between 25 and 29.9 kg/m2 , increases the risk of diabetes. Information about the feasibility of measuring, during routine occupational health examinations, predictors of elevated capillary blood glucose in overweight individuals is scarce. This study aims to identify factors that are associated with elevated capillary blood glucose and can be routinely measured in French overweight employees to develop targeted preventive strategies in the workplace...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29661086/consequences-of-non-medical-switch-among-patients-with-type-2-diabetes
#15
Natalia M Flores, Charmi A Patel, Brahim K Bookhart, Shaffeeulah Bacchus
OBJECTIVE: This study aimed to describe real-world experiences following a non-medical switch among adults with type 2 diabetes mellitus (T2DM) in the United States. METHODS: For this cross-sectional study, patients with T2DM (N = 451) provided data on demographics and how a non-medical switch of their anti-hyperglycemic agent (AHA) affected their general health, HbA1c levels, and medication management via an Internet-based survey. Patients self-reported their level of satisfaction with the original medication and emotional reactions to the non-medical switch...
April 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29659630/body-mass-index-of-92-027-patients-acutely-admitted-to-general-hospitals-in-denmark-associated-clinical-characteristics-and-30-day-mortality
#16
Sigrid Bjerge Gribsholt, Lars Pedersen, Bjørn Richelsen, Olaf Dekkers, Reimar Wernich Thomsen
BACKGROUND: Data are sparse on the range of BMI among patients acutely admitted to general hospitals. We investigated BMI values and associated patient characteristics, reasons for hospital admission, and mortality in Denmark. METHODS: We identified all persons with an acute inpatient admission 2011-2014 in Central Denmark Region and assessed BMI measurements recorded in the Clinical Information System. We used cross-sectional and cohort analyses to examine the BMI distribution and its association with demographic characteristics, comorbidities, medication use, tobacco smoking, reasons for admission, and 30-day mortality...
2018: PloS One
https://www.readbyqxmd.com/read/29657678/safety-of-sodium-glucose-cotransporter-2-inhibitors-sglt2-i-during-the-month-of-ramadan-in-muslim-patients-with-type-2-diabetes
#17
Alaaeldin Bashier, Azza Abdulaziz Khalifa, Elamin Ibrahim Abdelgadir, Maryam Ahmad Al Saeed, Amina Adil Al Qaysi, Murad Burhan Ali Bayati, Budoor Alemadi, Fawzi Bachet, Fatheya Alawadi, Mohammed Hassanein
Objectives: Sodium-glucose cotransporter 2 inhibitors (SGLT2-I) are a new class of antidiabetic drugs that might increase the risk of dehydration and hypoglycemia, particularly during the month of Ramadan in which Muslims abstain from eating and drinking for 14-16 hours daily. We aimed to provide real-life evidence about the safety of SGLT2-I during Ramadan. Methods: All patients over the age of 18 years on SGLT2-I before Ramadan 2016 who would be fasting during Ramadan were included...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29650821/-continuation-of-axitinib-for-advanced-renal-cell-carcinoma-by-the-application-of-homecare-urology-a-case-report-and-literature-review
#18
Satoshi Yazawa, Yuji Kato, Jin Nakahara, Toshio Miyata, Mototsugu Oya
A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of papillary RCC, G2, INF b, pT3, V1 in 1999. In 2008, sorafenib was started to treat multiple pulmonary metastases of RCC. In 2011, sorafenib was switched to sunitinib when radiologic progression was observed. In 2014, sunitinib was switched to axitinib when further radiologic progression was observed. In 2015, the patient was referred to Yazawa clinic for homecare urology when hospital visits became difficult due to cancer pain and bilateral lower-extremity muscle weakness...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650340/longitudinal-evaluation-of-efficacy-safety-and-nutritional-status-during-one-year-treatment-with-the-duodenal-jejunal-bypass-liner
#19
Nina Riedel, Katharina Laubner, Anne Lautenbach, Gerhard Schön, Matthias Schlensak, Rainer Stengel, Thomas Eberl, Frank Dederichs, Jens Aberle, Jochen Seufert
BACKGROUND: The endoscopic duodenal-jejunal bypass liner (DJBL) represents a novel temporary endoscopic approach for treatment of obesity-associated type 2 diabetes. Recent results from the German DJBL registry confirmed substantial positive metabolic effects of the DJBL in type 2 diabetes. However, the last Food and Drug Administration trial was stopped due to a high occurrence of hepatic abscesses (3.5%). OBJECTIVES: Here, we analyzed time courses of development of co-morbidities, nutritive changes, and occurrence of adverse events during the 1-year treatment phase with the DJBL in the German DJBL registry...
March 9, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29649953/prevalence-and-variables-associated-with-an-abnormal-ankle-brachial-index-among-patients-with-human-immunodeficiency-virus-acquired-immunodeficiency-syndrome
#20
Carlos A Hinojosa, Ana E Nunez-Salgado, Javier E Anaya-Ayala, Hugo Laparra-Escareno, Laura J Ortiz-Lopez, Jaime O Herrera-Caceres, Brenda E Crabtree-Ramirez, Juan G Sierra-Madero
Objectives The longer survival of patients with human immunodeficiency virus/acquired immunodeficiency syndrome and the introduction of the highly active antiretroviral therapy have increased the number of chronic conditions; among these, cardiovascular diseases. The aim of this study is to determine patient, disease, and factors associated with peripheral arterial disease in a population of patients with human immunodeficiency virus/acquired immunodeficiency syndrome. Methods A prospective nested case-control study of a cohort of patients with human immunodeficiency virus/acquired immunodeficiency syndrome was conducted in a tertiary medical center in Mexico City...
January 1, 2018: Vascular
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