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https://www.readbyqxmd.com/read/28538493/committee-opinion-no-703-summary-asymptomatic-microscopic-hematuria-in-women
#1
(no author information available yet)
Asymptomatic microscopic hematuria is an important clinical sign of urinary tract malignancy. Asymptomatic microscopic hematuria has been variably defined over the years. In addition, the evidence primarily is based on data from male patients. However, whether the patient is a man or a woman influences the differential diagnosis of asymptomatic microscopic hematuria, and the risk of urinary tract malignancy (bladder, ureter, and kidney) is significantly less in women than in men. Among women, being older than 60 years, having a history of smoking, and having gross hematuria are the strongest predictors of urologic cancer...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28537820/photodynamic-diagnosis-and-narrow-band-imaging-in-the-management-of-bladder-cancer-a-review
#2
Piotr Kutwin, Tomasz Konecki, Marcin Cichocki, Piotr Falkowski, Zbigniew Jabłonowski
BACKGROUND: Bladder cancer is the most common malignancy of the urinary tract. Its proper diagnosis and efficient treatment is still considered a challenge in Urology today. White Light Cystoscopy is a gold standard for the diagnosis, follow-up, and endoscopic treatment of bladder cancer. To improve the efficacy of bladder cancer management, photodynamic diagnosis and narrow-band imaging have been introduced to the urological armamentarium. OBJECTIVE AND METHODS: The article presents the current state of knowledge of technical solutions that are intended to improve the diagnosis and management of bladder cancer...
May 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28534548/-shared-decision-making-from-the-perspective-of-the-cancer-patient-participatory-roles-and-evaluation-of-the-process
#3
N Padilla Garrido, F Aguado Correa, M Ortega Moreno, J Bayo Calero, E Bayo Lozano
BACKGROUND: In Spain there is no clear knowledge about the degree to which Shared Decision Making (SDM) is carried out in the normal practice of oncology. Our article analyses the preferred role and the perceived role of oncological patients and measures the SDM process from their perspective. MATERIAL AND METHODS: Descriptive transversal study using a self-conducted questionnaire with patients with different types of cancer. To evaluate the role preferred and perceived by the patient we used The Control Preference Scales (CPS) and to measure SDM we used The nine-item Shared Decision Making Questionnaire (SDM-Q-9)...
April 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28534535/the-potential-of-organoids-in-urological-cancer-research
#4
REVIEW
Shangqian Wang, Dong Gao, Yu Chen
Technical advances in the development of organoid systems enable cell lines, primary adult cells, or stem or progenitor cells to develop into diverse, multicellular entities, which can self-renew, self-organize, and differentiate. These 3D organoid cultures have proven to be of value in increasing our understanding of the biology of disease and offer the potential of regenerative and genetic therapies. The successful application of 3D organoids derived from adult tissue into urological cancer research can further our understanding of these diseases and could also provide preclinical cancer models to realize the precision medicine paradigm by therapeutic screening of individual patient samples ex vivo...
May 23, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28520829/association-between-combined-tmprss2-erg-and-pca3-rna-urinary-testing-and-detection-of-aggressive-prostate-cancer
#5
Martin G Sanda, Ziding Feng, David H Howard, Scott A Tomlins, Lori J Sokoll, Daniel W Chan, Meredith M Regan, Jack Groskopf, Jonathan Chipman, Dattatraya H Patil, Simpa S Salami, Douglas S Scherr, Jacob Kagan, Sudhir Srivastava, Ian M Thompson, Javed Siddiqui, Jing Fan, Aron Y Joon, Leonidas E Bantis, Mark A Rubin, Arul M Chinnayian, John T Wei, Mohamed Bidair, Adam Kibel, Daniel W Lin, Yair Lotan, Alan Partin, Samir Taneja
Importance: Potential survival benefits from treating aggressive (Gleason score, ≥7) early-stage prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolent disease. Objective: To evaluate the a priori primary hypothesis that combined measurement of PCA3 and TMPRSS2:ERG (T2:ERG) RNA in the urine after digital rectal examination would improve specificity over measurement of prostate-specific antigen alone for detecting cancer with Gleason score of 7 or higher...
May 18, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28516158/a-management-algorithm-for-mitomycin-c-induced-cystitis
#6
Amy N Luckenbaugh, Rory M Marks, David C Miller, Alon Z Weizer, John T Stoffel, Jeffrey S Montgomery
Background/Objective: A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Currently, there is no established treatment algorithm for MMC-induced cystitis. Methods: Members of the Urologic Surgery Quality Collaborative (USQC), a group composed of over 160 private and academic urologists, met to discuss the management of patients with cystitis following MMC therapy...
April 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/28515817/systematic-review-of-the-potential-role-of-cannabinoids-as-antiproliferative-agents-for-urological-cancers
#7
REVIEW
Shreyas Gandhi, Gaurav Vasisth, Anil Kapoor
INTRODUCTION: The palliative effects of cannabis sativa (marijuana), which include appetite stimulation, attenuation of nausea and emesis, and pain relief, are well known. The active components of cannabis sativa (cannabinoids) and their derivatives have received growing interest due to their diverse pharmacological activities, such as cell growth inhibition and tumour regression. The aim of this review is to look at the current evidence on the antiproliferative effects of cannabinoids in urological malignancies, including renal, prostate, bladder, and testicular cancers...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28514929/five-year-outcomes-from-a-prospective-trial-of-image-guided-accelerated-hypofractionated-proton-therapy-for-prostate-cancer
#8
Randal H Henderson, Curtis Bryant, Bradford S Hoppe, R Charles Nichols, William M Mendenhall, Stella Flampouri, Zhong Su, Zuofeng Li, Christopher G Morris, Nancy P Mendenhall
PURPOSE: To report 5-year outcomes of a prospective trial of image-guided accelerated hypofractionated proton therapy (AHPT) for prostate cancer. PATIENTS AND METHODS: 215 prostate cancer patients accrued to a prospective institutional review board-approved trial of 70Gy(RBE) in 28 fractions for low-risk disease (n = 120) and 72.5Gy(RBE) in 29 fractions for intermediate-risk disease (n = 95). This trial excluded patients with prostate volumes of ≥60 cm(3) or International Prostate Symptom Scores (IPSS) of ≥15, patients on anticoagulants or alpha-blockers, and patients in whom dose-constraint goals for organs at risk (OAR) could not be met...
July 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28508102/role-of-lymph-node-dissection-during-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-cancer-multi-institutional-large-retrospective-study-jcog1110a
#9
Junichi Inokuchi, Kentaro Kuroiwa, Yoshiyuki Kakehi, Mikio Sugimoto, Toshiki Tanigawa, Hiroyuki Fujimoto, Momokazu Gotoh, Naoya Masumori, Osamu Ogawa, Masatoshi Eto, Chikara Ohyama, Akito Yamaguchi, Hideyasu Matsuyama, Tomohiko Ichikawa, Tomohiko Asano, Junki Mizusawa, Junko Eba, Seiji Naito
PURPOSE: To evaluate the impact of lymph node dissection (LND) on clinical outcome during radical nephroureterectomy (RNU) for patients with upper urinary tract urothelial cancer (UTUC). METHODS: We, the Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG), retrospectively collected data from patients with non-metastatic UTUC who underwent RNU in 30 centers in 1995-2009. Ineligible patients and patients with previous and/or synchronous bladder cancer were excluded, and the remaining 2037 patients were analyzed...
May 15, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28501271/virtual-cystoscopy-computed-tomography-urography-and-optical-cystoscopy-for-the-detection-and-follow-up-for-bladder-cancer
#10
D Ibáñez Muñoz, I Quintana Martínez, A Fernández Militino, D Sánchez Zalabardo, L Sarria Octavio de Toledo, R Cozcolluela Cabrejas
OBJECTIVES: To evaluate the utility of virtual cystoscopy (VC) performed with CT urography in patients being studied under gross hematuria or patients being followed-up after a previous bladder cancer and compare the results with those obtained with gold standard technique (optical cystoscopy). METHODS: Retrospective study of 117 patients who were referred for VC by the Urology Department between May 2014 and May 2015. Those patients presented with gross hematuria or they were previously treated patients from bladder cancer being followed up...
May 10, 2017: Radiología
https://www.readbyqxmd.com/read/28499617/community-based-outcomes-of-open-versus-robot-assisted-radical-prostatectomy
#11
Annika Herlemann, Janet E Cowan, Peter R Carroll, Matthew R Cooperberg
BACKGROUND: Identifying the optimal surgical approach for patients with localized prostate cancer (PCa) managed in the community setting remains controversial due to the lack of robust, prospective data. OBJECTIVE: To assess surgical outcomes and changes in urinary and sexual quality of life (QOL) over time in patients undergoing radical prostatectomy (RP). DESIGN, SETTING, AND PARTICIPANTS: Our study included patients enrolled in Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE), a large, prospective, mostly community-based, nationwide PCa registry, who underwent RP between 2004 and 2016...
May 9, 2017: European Urology
https://www.readbyqxmd.com/read/28498468/microrna-379-5p-plays-a-tumor-suppressive-role-in-human-bladder-cancer-growth-and-metastasis-by-directly-targeting-mdm2
#12
Deyao Wu, Xiaobing Niu, Jun Tao, Pengchao Li, Qiang Lu, Aiming Xu, Wei Chen, Zengjun Wang
Bladder cancer is the second most common urological malignancy in the US and is the most frequently diagnosed urological malignancy in China. An increasing amount of evidence indicates that microRNAs perform extremely important functions in many biological processes related to the formation and progression of cancers, including bladder cancer. Previous studies have reported that microRNA‑379-5p (miR-379-5p) is involved in tumour initiation and development in human cancers. However, the expression pattern, biological functions and the underlying mechanisms of miR-379-5p in bladder cancer remain unknown...
April 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28497893/the-4kscore-blood-test-accurately-identifies-men-with-aggressive-prostate-cancer-prior-to-prostate-biopsy-with-or-without-dre-information
#13
Stephen M Zappala, Yan Dong, Vincent Linder, Michael Reeve, Daniel D Sjoberg, Vinita Mathur, Richard Roberts, David Okrongly, Jay Newmark, Garnnum Sant, Mitchell Steiner
INTRODUCTION: The 4Kscore Test is a prebiopsy blood test that incorporates four prostate protein biomarkers along with patient clinical information to determine a man's risk for high-grade, aggressive (Gleason ≥7) prostate cancer. However, some men likely to benefit from the test may be seen in primary care settings where the digital rectal examination (DRE) information is not always obtained. In this study, we assessed the clinical validity of the 4Kscore Test when the DRE information was not included in the algorithm...
May 12, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28497404/sexual-dysfunction-following-rectal-cancer-surgery
#14
REVIEW
V Celentano, R Cohen, J Warusavitarne, O Faiz, M Chand
INTRODUCTION: Sexual and urological problems after surgery for rectal cancer are common, multifactorial, inadequately discussed, and untreated. The urogenital function is dependent on dual autonomic sympathetic and parasympathetic innervation, and four key danger zones exist that are at risk for nerve damage during colorectal surgery: one of these sites is in the abdomen and three are in the pelvis. The aim of this study is to systematically review the epidemiology of sexual dysfunction following rectal cancer surgery, to describe the anatomical basis of autonomic nerve-preserving techniques, and to explore the scientific evidence available to support the laparoscopic or robotic approach over open surgery...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28494579/multiparametric-prostate-mri-technical-conduct-standardized-report-and-clinical-use-a-narrative-review
#15
Matteo Manfredi, Fabrizio Mele, Diletta Garrou, Jochen Walz, Jurgen J Fütterer, Filippo Russo, Lorenzo Vassallo, Arnauld Villers, Mark Emberton, Massimo Valerio
Multiparametric prostate MRI (mp-MRI) is an emerging imaging modality for diagnosis, characterization, staging, and treatment planning of prostate cancer (PCa). The technique, results reporting, and its role in clinical practice have been the subject of significant development over the last decade. Although mp-MRI is not yet routinely used in the diagnostic pathway, almost all urological guidelines have emphasized the potential role of mp-MRI in several aspects of PCa management. Moreover, new MRI sequences and scanning techniques are currently under evaluation to improve the diagnostic accuracy of mp-MRI...
May 11, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28492153/prognostic-value-of-p53-expression-intensity-in-urothelial-cancers
#16
Samina Qamar, Qazi Adil Inam, Sobia Ashraf, M Safdar Khan, M Abbas Khokhar, Nukhbatullah Awan
OBJECTIVE: To determine association of immunohistochemical expression intensity of p53 with grade and stage of urothelial cancers. STUDY DESIGN: Descriptive cross-sectional analytical study. PLACE AND DURATION OF STUDY: Pathology Department, King Edward Medical University, Lahore, from January to December 2016. METHODOLOGY: Data of transurethral resection/radical cystesctomy urinary bladder biopsies was collected. Clinical, radiological and cystoscopic findings of patients were noted from patients' charts in the Urology Ward...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28492149/the-histopathological-parameters-affecting-biochemical-recurrence-in-radical-prostatectomies
#17
Yelda Dere, Aysegu Aksoy Altinboga, Kaan Bal, Aylin Calli, Murat Ermete, Aysegul Akder Sari
OBJECTIVE: To determine the relationship between biochemical recurrence and other histopathological factors in prostate cancer. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Pathology and Urology Departments, Izmir Ataturk Training and Research Hospital, between 2001 - 2013. METHODOLOGY: 117 cases diagnosed with prostatic adenocarcinoma and treated by radical prostatectomy were reviewed retrospectively for histopathological features; whereas, other prognostic findings were noted...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28479237/adjuvant-therapy-for-high-risk-localized-kidney-cancer-emerging-evidence-and-future-clinical-trials
#18
REVIEW
Andrew T Lenis, Nicholas M Donin, David C Johnson, Izak Faiena, Amirali Salmasi, Alexandra Drakaki, Arie Belldegrun, Allan Pantuck, Karim Chamie
PURPOSE: We will review the literature on adjuvant therapies for patients with high-risk localized kidney cancer following surgical treatment. Two recently published prospective trials with conflicting results will be reconciled within the context of their respective designs. Finally, we will spotlight upcoming trials that use novel immunotherapy-based checkpoint inhibitors and have the potential to establish a new standard of care. MATERIALS AND METHODS: A PubMed search was performed for English language articles using the keywords "renal cell carcinoma," "kidney cancer," "immunotherapy," "targeted therapy," and "adjuvant therapy" published through January 2017...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28473080/acr-appropriateness-criteria-%C3%A2-prostate-cancer-pretreatment-detection-surveillance-and%C3%A2-staging
#19
Fergus V Coakley, Aytekin Oto, Lauren F Alexander, Brian C Allen, Brian J Davis, Adam T Froemming, Pat F Fulgham, Keyanoosh Hosseinzadeh, Christopher Porter, V Anik Sahni, David M Schuster, Timothy N Showalter, Aradhana M Venkatesan, Sadhna Verma, Carolyn L Wang, Erick M Remer, Steven C Eberhardt
Despite the frequent statement that "most men die with prostate cancer, not of it," the reality is that prostate cancer is second only to lung cancer as a cause of death from malignancy in American men. The primary goal during baseline evaluation of prostate cancer is disease characterization, that is, establishing disease presence, extent (local and distant), and aggressiveness. Prostate cancer is usually diagnosed after the finding of a suspicious serum prostate-specific antigen level or digital rectal examination...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473071/acr-appropriateness-criteria-%C3%A2-hematospermia
#20
Keyanoosh Hosseinzadeh, Aytekin Oto, Brian C Allen, Fergus V Coakley, Barak Friedman, Pat F Fulgham, Matthew S Hartman, Matthew T Heller, Christopher Porter, V Anik Sahni, Gary S Sudakoff, Sadhna Verma, Carolyn L Wang, Don C Yoo, Erick M Remer, Steven C Eberhardt
Most men with hematospermia or hemospermia (HS) are young (<40 years of age), presenting with transient or episodic HS without other signs or symptoms of disease. The condition is self-limiting in most cases and idiopathic in nature. When a cause can be identified, infections of the urogenital tract are the most common. Imaging does not play a role in this patient population. In older men (>40 years of age), clinical screening for prostate cancer is advised. Furthermore, when HS is persistent or has symptoms, causes include obstruction or stricture at the level of the verumontanum, calcifications or calculi in the prostate, ejaculatory ducts or seminal vesicles, and cysts arising within these structures...
May 2017: Journal of the American College of Radiology: JACR
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