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https://www.readbyqxmd.com/read/29040184/proceedings-from-the-1st-international-conference-current-concepts-and-controversies-in-gynecologic-and-urologic-oncology
#1
Olga Matylevich, Sergey Mavrichev, Andrei Pletnev, Alesya Evmenenko, Aleksey Shevchuk, Valentina Suslova, Sergey Taranenko, Elena Dolomanova, Dmitry Rovsky, Anna Portyanko, Jubilee Brown, Robert Wendel Naumann, Kathleen Schmeler, Anna Plotkin, Sophia Michaelson, Mary Eiken, Edward Trimble, Thomas Randall
The N.N. Alexandrov National Cancer Center of Belarus organized a collaborative international conference entitled 'Current Concepts and Controversies in Gynecologic and Urologic Oncology' with the International Gynecologic Cancer Society and the United States National Cancer Institute. International, regional, and national experts presented recent developments and local conditions in the treatment of gynecologic cancers. Findings were reviewed with the intent of optimizing the management of women with gynecologic cancers across the Commonwealth of Independent States region...
October 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29039528/lncrna-ror-promotes-the-proliferation-of-renal-cancer-and-is-negatively-associated-with-favorable-prognosis
#2
Jianguo Shi, Wen Zhang, Hongyang Tian, Qiang Zhang, Tongyi Men
Renal cell carcinoma (RCC) is one of the third most common types of urological cancer worldwide. Long non‑coding RNA (lncRNA) ROR has been reported to be important in regulating the malignant activities of different types of cancer, however, the function of lncRNA ROR in RCC remains to be fully elucidated. In order to investigate the function of lncRNA ROR in RCC, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis was used to detect the expression of lncRNA ROR in renal cancer tissues and adjacent tissues...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037766/frequency-and-markers-of-precursor-lesions-and-implications-for-the-pathogenesis-of-testicular-germ-cell-tumors
#3
Finn Edler von Eyben, Marie Bjødstrup Jensen, Søren Høyer
BACKGROUND: The World Health Organization classification of urologic cancer 2016 describes 3 noninvasive precursor lesions for testicular germ cell tumor type II (TGCT) of young adults. Germ cell neoplasia in situ is the initial precursor lesion. Intratubular seminoma (ITSE), and intratubular embryonal carcinoma (ITEC) are 2 intermediate precursor lesions. Microinvasive testicular germ cell tumor (MGCT) is an invasive precursor lesion. MATERIALS AND METHODS: We undertook a retrospective study of testes obtained using orchiectomy for TGCT and examined precursor lesions...
September 5, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29034698/an-insight-into-the-patient-s-response-to-a-diagnosis-of-urological-cancer
#4
Beverley Anderson
A cancer diagnosis and the patient's response to the news pertains to all types of cancer, however, in this article, the focus is on urological cancer. Intrinsic to the management of this patient group is the urology multidisciplinary team, in which the role of the cancer nurse specialist (CNS) is pivotal. For most people, a cancer diagnosis is arguably their worst fear. It is therefore prudent that a holistic approach is used when determining care and ensuring that appropriate support is forthcoming. This necessitates an assessment of the physical, psychological/emotional, psycho-social, spiritual and cultural components of the individual's healthcare needs, and accordingly, devising a plan of care to secure the best outcomes...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29034236/prognostic-value-of-the-new-prostate-cancer-international-society-of-urological-pathology-grade-groups
#5
Anne Offermann, Silke Hohensteiner, Christiane Kuempers, Julika Ribbat-Idel, Felix Schneider, Finn Becker, Marie Christine Hupe, Stefan Duensing, Axel S Merseburger, Jutta Kirfel, Markus Reischl, Verena Lubczyk, Rainer Kuefer, Sven Perner
Gleason grading is the best independent predictor for prostate cancer (PCa) progression. Recently, a new PCa grading system has been introduced by the International Society of Urological Pathology (ISUP) and is recommended by the World Health Organization (WHO). Following studies observed more accurate and simplified grade stratification of the new system. Aim of this study was to compare the prognostic value of the new grade groups compared to the former Gleason Grading and to determine whether re-definition of Gleason Pattern 4 might reduce upgrading from prostate biopsy to radical prostatectomy (RP) specimen...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29034222/risk-factor-assessment-in-high-risk-bacillus-calmette-gu%C3%A3-rin-treated-non-muscle-invasive-bladder-cancer
#6
Serge Holz, Simone Albisinni, Jacques Gilsoul, Michel Pirson, Véronique Duthie, Thierry Quackels, Marc Vanden Bossche, Thierry Roumeguère
OBJECTIVE: To assess the risk factors associated with recurrence, progression and survival in high-risk non-muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG) and validate the European Organization for Research and Treatment of Cancer (EORTC) and Spanish Urological Club for Oncological Treatment (CUETO) scores. PATIENTS AND METHODS: We retrospectively analyzed all BCG-treated NMIBC patients from 1998 to 2012. Multiple variables were tested as risk factors for recurrence-free survival and progression-free survival (PFS)...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29031295/competitive-amperometric-immunosensor-for-determination-of-p53-protein-in-urine-with-carbon-nanotubes-gold-nanoparticles-screen-printed-electrodes-a-potential-rapid-and-noninvasive-screening-tool-for-early-diagnosis-of-urinary-tract-carcinoma
#7
Marco Giannetto, Maria Vittoria Bianchi, Monica Mattarozzi, Maria Careri
Since p53 protein has become recognized biomarker for both diagnostic and therapeutic purposes in oncological diseases with particular relevance for bladder cancer, it is highly desirable to search for a novel sensing tool for detecting the patient's p53 level at the early stage. Here we report the first study on the development and validation of a novel disposable competitive amperometric immunosensor for determination of p53 protein at subnanomolar levels, based on p53 immobilization on gold nanoparticles/carbon nanotubes modified screen-printed carbon electrodes...
October 23, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029431/does-uneven-geographic-distribution-of-urologists-effect-bladder-and-prostate-cancers-mortality-national-health-insurance-data-in-korea-from-2007-2011
#8
Jae Heon Kim, Hwa Yeon Sun, Hyun Jung Kim, Young Myoung Ko, Dong-Il Chun, Jae Young Park
The relationship between distribution of urologists and mortality of bladder and prostate cancers has not been clearly established. The aim of this study was to investigate the relationship between uneven distribution of urologists and urologic cancer specific mortality at country level. Data from the National Health Insurance Service and National Statistical Office in Korea from 2007 to 2011 were analyzed in this ecological study. Univariate and multivariable regression analyses were performed to determine risk factors for age standardized mortality rates (ASMR) of bladder and prostate cancers...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29025456/a-finger-or-not-prostate-examinations-by-non-urologists-at-a-south-african-academic-institution
#9
Kalli Spencer
BACKGROUND: According to the South African (SA) National Cancer Registry 2009, prostate cancer is the most commonly diagnosed solid-organ cancer in SA men: the incidence increases at ~3% every year, with 1/26 men developing prostate cancer in their lifetime and five men dying every day. Screening for prostate cancer by performing a digital rectal examination (DRE) adds to the sensitivity and specificity of serum prostate-specific antigen (PSA) testing and is an important component of the assessment for the early detection of prostate cancer...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29019329/implications-of-observer-variation-in-gleason-scoring-of-prostate-cancer-on-clinical-management-a-collaborative-audit
#10
A Harbias, E Salmo, A Crump
BACKGROUND: Prostate cancer is the most frequently diagnosed cancer in men. Histological tumour grade is a strong predictor of outcome and helps determine what treatment options are offered. There are numerous studies on Inter-observer agreement/variability on prostate cancer grading. In this study, we were looking to establish if disconcordance between pathologists when grading prostate cancer, could affect treatment options offered to men. METHODS: In Greater Manchester West Cancer Sector, all prostate cancer biopsies undergo a central review by three pathologists with a special interest in urological pathology prior to referral for treatment at specialist centres...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28994093/circulating-tumor-cells-in-urological-cancers
#11
Martin Cegan, Christopher Kobierzycki, Katarina Kolostova, Imrich Kiss, Vladimir Bobek, Robert Grill
Circulating tumor cells (CTC) represent a very small subpopulation of the cancer cells found in the bloodstream of patients in the metastatic phase of neoplastic disease. Due to the timeline of the disease, they are regarded as a negative prognostic marker. This study focused on determining CTC percentages; these values vary between different types of cancer. In addition to their diagnostic use, CTCs may also be used to treat the disease. Calculating CTC population size and analyzing their biology in patients in advanced stages of cancer may prove valuable in creating a molecular profile for the disease...
October 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28992666/-an-increase-in-cases-of-bladder-tamponade-due-to-cystitis-among-elderly-women-and-clinical-background-factors
#12
Kazunari Tsuchihashi, Yuki Makino, Masahiro Emura, Kazutaka Kida, Yosuke Shimizu, Sojun Kanamaru, Ryo Iguchi, Tetsuya Noguchi, Miharu Sasaki, Noriyuki Ito
Bladder tamponade is thought to be caused mainly by bladder cancer or radiation cystitis. However, in women, it may often be caused by cystitis in clinical settings. This has not been noted in previous reports of bladder tamponade in Japan. Thus, we retrospectively analyzed the clinical features of 83 male and 41 female patients with bladder tamponade. Seventy-four patients were treated at Nishi-Kobe Medical Center between April 2005 and March 2015, and 50 were treated at Shizuoka City Shizuoka Hospital between November 2008 and March 2015...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28988782/predictors-of-genitourinary-malignancy-in-patients-with-asymptomatic-microscopic-hematuria
#13
Patrick Samson, Nikhil Waingankar, Paras Shah, Derek Friedman, Louis Kavoussi, Justin Han
OBJECTIVES: To report the incidence of genitourinary malignancy and identify associated risk factors in patients undergoing urologic evaluation for asymptomatic microscopic hematuria (AMH) according to the 2012 American Urologic Association guidelines. SUBJECTS/PATIENTS AND METHODS: A retrospective institutional review of patients who underwent evaluation for AMH between 2012 and 2015 was conducted. Covariates analyzed included age, sex, smoking status, history of other malignancy, history of pelvic irradiation, presence of irritative voiding symptoms, use of anticoagulation, number of red blood cells on microscopic urinalysis, and guideline adherence...
October 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28988753/a-biopsy-based-17-gene-genomic-prostate-score-as-a-predictor-of-metastases-and-prostate-cancer-death-in-surgically-treated-men-with-clinically-localized-disease
#14
Stephen K Van Den Eeden, Ruixiao Lu, Nan Zhang, Charles P Quesenberry, Jun Shan, Jeong S Han, Athanasios C Tsiatis, Amethyst D Leimpeter, H Jeffrey Lawrence, Phillip G Febbo, Joseph C Presti
BACKGROUND: A 17-gene biopsy-based reverse transcription polymerase chain reaction assay, which provides a Genomic Prostate Score (GPS-scale 0-100), has been validated as an independent predictor of adverse pathology and biochemical recurrence after radical prostatectomy (RP) in men with low- and intermediate-risk prostate cancer (PCa). OBJECTIVE: To evaluate GPS as a predictor of PCa metastasis and PCa-specific death (PCD) in a large cohort of men with localized PCa and long-term follow-up...
October 5, 2017: European Urology
https://www.readbyqxmd.com/read/28985026/urologic-malignancies-in-kidney-transplantation
#15
Laura A Hickman, Deirdre Sawinski, Thomas Guzzo, Jayme E Locke
With advances in immunosuppression, graft and patient outcomes after kidney transplantation have improved considerably. As a result, long-term complications of transplant, such as urologic malignancies, have become increasingly important. Kidney transplant recipients, for example, have a seven-fold risk of renal cell carcinoma (RCC) and three-fold risk of urothelial carcinoma (UC) compared to the general population. While extrapolation of data from the general population suggest that routine cancer screening in transplant recipients would allow for earlier diagnosis and management of these potentially lethal malignancies, currently there is no consensus for post-transplant RCC or UC screening as supporting data are limited...
October 6, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28984720/prevention-of-bladder-cancer-incidence-and-recurrence-tobacco-use
#16
Francesco Soria, Giancarlo Marra, Otakar Čapoun, Viktor Soukup, Paolo Gontero
PURPOSE OF REVIEW: To summarize the current knowledge about smoking carcinogenesis in bladder cancer (BCa), individual susceptibility and impact of smoking on incidence and outcomes of nonmuscle invasive BCa (NMIBC) and muscle-invasive BCa (MIBC). To assess the impact of smoking cessation on oncological outcomes. RECENT FINDINGS: Smoking pattern, intensity, and duration are responsible for an increased risk of developing BCa and for worse tumor features at presentation...
October 3, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28982830/communicating-risk-in-active-surveillance-of-localised-prostate-cancer-a-protocol-for-a-qualitative-study
#17
Frances Rapport, Anne Hogden, Howard Gurney, David Gillatt, Mia Bierbaum, Patti Shih, Kate Churruca
INTRODUCTION: One in five men is likely to receive a diagnosis of prostate cancer (PCa) by the age of 85 years. Men diagnosed with low-risk PCa may be eligible for active surveillance (AS) to monitor their cancer to ensure that any changes are discovered and responded to in a timely way. Communication of risk in this context is more complicated than determining a numerical probability of risk, as patients wish to understand the implications of risk on their lives in concrete terms. Our study will examine how risk for PCa is perceived, experienced and communicated by patients using AS with their health professionals, and the implications for treatment and care...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28980114/cancer-survivors-social-context-in-the-return-to-work-process-narrative-accounts-of-social-support-and-social-comparison-information
#18
M Armaou, L Schumacher, E A Grunfeld
Purpose Returning to work is a process that is intertwined with the social aspects of one's life, which can influence the way in which that person manages their return to work and also determines the support available to them. This study aimed to explore cancer patients' perceptions of the role of their social context in relation to returning to work following treatment. Methods Twenty-three patients who had received a diagnosis of either urological, breast, gynaecological, or bowel cancer participated in semi-structured interviews examining general perceptions of cancer, work values and perceptions of the potential impact of their cancer diagnosis and treatment on work...
October 4, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28974310/bladder-sparing-radiotherapy-for-muscle-invasive-bladder-cancer-a-survey-of-providers-to-determine-barriers-and-enablers
#19
Melanie Walker, Simon D French, R Christopher Doiron, Kelly Brennan, Deb Feldman-Stewart, D Robert Siemens, William J Mackillop, Christopher M Booth
BACKGROUND: To understand barriers and enablers to use of curative-intent radiotherapy (RT) for muscle-invasive bladder cancer using the Theoretical Domains Framework (TDF). METHODS: Canadian urologists, radiation oncologists (ROs) and medical oncologists (MOs) participated in a web-based survey to assess barriers and enablers to use of RT. Survey questions were thematically mapped to TDF domains. Logistic regression was used to identify TDF domains associated with high referral/use of RT...
September 30, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28973248/association-between-use-of-antithrombotic-medication-and-hematuria-related-complications
#20
COMPARATIVE STUDY
Christopher J D Wallis, Tristan Juvet, Yuna Lee, Rano Matta, Sender Herschorn, Ronald Kodama, Girish S Kulkarni, Raj Satkunasivam, William Geerts, Anne McLeod, Steven A Narod, Robert K Nam
Importance: Antithrombotic medications are among the most commonly prescribed medications. Objective: To characterize rates of hematuria-related complications among patients taking antithrombotic medications. Design, Setting, and Participants: Population-based, retrospective cohort study including all citizens in Ontario, Canada, aged 66 years and older between 2002 and 2014. The final follow-up date was December 31, 2014. Exposures: Receipt of an oral anticoagulant or antiplatelet medication...
October 3, 2017: JAMA: the Journal of the American Medical Association
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