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Urologic cancer

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https://www.readbyqxmd.com/read/29455907/introduction-to-a-seminar-on-implementation-and-de-implementation-to-improve-urologic-cancer-care
#1
REVIEW
Ted A Skolarus
No abstract text is available yet for this article.
February 15, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29452979/3-piece-inflatable-penile-prosthesis-placement-following-radical-cystoprostatectomy-and-urinary-diversion-technique-and-outcomes
#2
Jeffrey Loh-Doyle, Mukul B Patil, Hari Sawkar, Kevin Wayne, Stuart D Boyd
BACKGROUND: After radical cystoprostatectomy (RC), postoperative erectile dysfunction (ED) is a common consequence with multiple contributing etiologies. The inflatable penile prosthesis (IPP) offers patients a definitive treatment option when ED is refractory to medical therapies. Because of the hostile postoperative anatomy of these patients, a careful surgical approach is necessary for successful outcomes and to avoid adjacent organ injury. To date, there is no series describing the outcomes of 3-piece IPP placement in patients with urinary diversions...
February 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29445424/promoter-methylation-of-dna-damage-repair-ddr-genes-in-human-tumor-entities-rbbp8-ctip-is-almost-exclusively-methylated-in-bladder-cancer
#3
Jolein Mijnes, Jürgen Veeck, Nadine T Gaisa, Eduard Burghardt, Tim C de Ruijter, Sonja Gostek, Edgar Dahl, David Pfister, Sebastian C Schmid, Ruth Knüchel, Michael Rose
Background: Genome-wide studies identified pan-cancer genes and shared biological networks affected by epigenetic dysregulation among diverse tumor entities. Here, we systematically screened for hypermethylation of DNA damage repair (DDR) genes in a comprehensive candidate-approach and exemplarily identify and validate candidate DDR genes as targets of epigenetic inactivation unique to bladder cancer (BLCA), which may serve as non-invasive biomarkers. Methods: Genome-wide DNA methylation datasets (2755 CpG probes of n = 7819 tumor and n = 659 normal samples) of the TCGA network covering 32 tumor entities were analyzed in silico for 177 DDR genes...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29434954/a-novel-function-of-nucb2-in-promoting-the-development-and-invasion-of-renal-cell-carcinoma
#4
Huan Xu, Wenzhi Li, Kai Qi, Juan Zhou, Meng Gu, Zhong Wang
Previous studies have assessed nucleobindin 2 (NUCB2) expression in multiple urological cancer cell lines and detected its effect on renal cancer cell apoptosis. Additionally, certain reports have indicated a novel function of NUCB2 in promoting invasion in renal cancer. The levels of NUCB2 expression in different tumor cell lines were detected by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Human NUCB2 and β-actin (ACTB) cDNA plasmids were inserted into lentivirus plasmids, which were then transfected into 786-O cells...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434673/practical-differences-between-luteinizing-hormone-releasing-hormone-agonists-in-prostate-cancer-perspectives-across-the-spectrum-of-care
#5
REVIEW
Davide Meani, Mladen Solarić, Harri Visapää, Rose-Marie Rosén, Robert Janknegt, Majana Soče
Background: Androgen deprivation therapy (ADT) with luteinizing hormone-releasing hormone (LHRH) agonists is well established for the treatment of men with metastatic prostate cancer. As clear differences in efficacy, safety, or tolerability between the available LHRH agonists are lacking, the healthcare management team needs to look to practical differences between the formulations when selecting therapy for their patients. Moreover, as the economic burden of prostate cancer rises alongside earlier diagnosis and improved survival, the possibility for cost savings by using products with specific features is growing in importance...
February 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29430502/immune-responses-to-neoadjuvant-chemotherapy-in-muscle-invasive-bladder-cancer
#6
REVIEW
Amir Sherif, Malin Winerdal, Ola Winqvist
The secondary effects of chemotherapy, with bone marrow depression and risk of leukopenia, has traditionally been considered being detrimental for the immune system. However, growing evidence suggests a main role for chemotherapy in antitumor immunomodulation. With reference to cisplatin, which is the basis of neoadjuvant chemotherapy in muscle invasive bladder cancer, four different aspects of immunomodulation has thus far been described; increased MHC class I expression, recruitment and proliferation of effector cells, enhancement of tumor-lytic activity of cytotoxic effectors and downregulation of immunosuppressive actors in the microenvironment...
January 20, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29429896/metabolic-syndrome-is-not-associated-with-greater-evidences-of-proliferative-inflammatory-atrophy-and-inflammation-in-patients-with-suspected-prostate-cancer
#7
Giorgio I Russo, Sebastiano Cimino, Giorgia Giranio, Federica Regis, Vincenzo Favilla, Salvatore Privitera, Fabio Motta, Rosario Caltabiano, Arnulf Stenzl, Tilman Todenhöfer, Giuseppe Morgia
INTRODUCTION AND OBJECTIVES: To evaluate the association between metabolic syndrome (MetS) and proliferative inflammatory atrophy (PIA) in patients with suspected prostate cancer (PCa). PATIENTS AND METHODS: From June 2015 to July 2016, we conducted the FIERY (Flogosis Increased Events of pRostatic biopsY) study at the Urology section, Department of Surgery of the University of Catania (Local registration number: #131/2015). A total of 205 patients with elevated prostate-specific antigen (≥ 4 ng/ml) or clinical suspicion of PCa who underwent primary transperineal prostate biopsy were included in this cross-sectional study...
February 8, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29427002/long-term-oncological-outcomes-after-robotic-partial-nephrectomy-for-renal-cell-carcinoma-a-prospective-multicentre-study
#8
Jean-Baptiste Beauval, Benoit Peyronnet, Thibaut Benoit, Bastien Cabarrou, Thomas Seisen, Mathieu Roumiguié, Benjamin Pradere, Zine-Eddine Khene, Quentin Manach, Gregory Verhoest, Mathieu Thoulouzan, Jerome Parra, Nicolas Doumerc, Romain Mathieu, Christophe Vaessen, Michel Soulié, Morgan Roupret, Karim Bensalah
PURPOSE: This study aimed at reporting the long-term oncological outcomes of robotic partial nephrectomy (RPN) for renal cell carcinoma (RCC). METHODS: Data from all consecutive patients who underwent RAPN for RCC from July 2009 to January 2012 in three departments of urology were prospectively collected. Overall survival (OS), cancer-specific survival (CSS) and disease free-survival (DFS) were estimated using the Kaplan-Meier method. Prognostic factors associated with CSS were sought in univariate analysis...
February 9, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29422356/will-68ga-psma-radioligands-be-the-only-choice-for-nuclear-medicine-in-prostate-cancer-in-the-near-future-a-clinical-update
#9
V Cuccurullo, G D di Stasio, L Evangelista, A Ciarmiello, L Mansi
Prostate Cancer (PCa) represents the most common malignant tumor in men but according to the European Association of Urology (EAU) guidelines, a mass screening for PCa diagnosis should not be performed due to over-diagnosis and over-treatment related problems. An early clinical diagnosis is possible, mainly based on digital rectal examination and Prostatic Specific Agent (PSA) testing. However, the only mandatory test to define the presence of PCa is ultrasound guided-biopsy, obtained on multiple samples, which has also a high prognostic value...
February 5, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29417289/thromboprophylaxis-and-the-route-of-administration-of-chemotherapy-in-testicular-cancer-patients-in-german-speaking-countries
#10
Tim Nestler, Johannes Huber, Adrienne M Laury, Hendrik Isbarn, Axel Heidenreich, Hans U Schmelz, Christian G Ruf
PURPOSE: Due to the excellent cure rates for testicular cancer (TC), focus has shifted towards decreasing therapy-related morbidities. Thrombosis is a frequent complication of cisplatin chemotherapy. Furthermore, the optimal route of administration for chemotherapy is still under debate. The purpose of this study was to assess the patterns of care concerning dosing and duration of thromboprophylaxis currently utilized in TC patients in German-speaking countries as well as the route of chemotherapy administration...
February 7, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29416825/prognosis-of-men-with-penile-metastasis-and-malignant-priapism-a-systematic-review
#11
REVIEW
Andrea Cocci, Oliver W Hakenberg, Tommaso Cai, Gabriella Nesi, Lorenzo Livi, Beatrice Detti, Andrea Minervini, Girolamo Morelli, Marco Carini, Sergio Serni, Mauro Gacci
Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease. We reviewed the literature relating to all case reports, series and reviews about penile metastasis, from 2003 to 2013, through a Medline search. We identified 63 articles and 69 patients. Metastases were located on the root (38.8%), the shaft (38.8%) or the glans (22.2%) of the penis...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416205/upper-urinary-tract-urothelial-cancer-in-croatian-and-bosnian-endemic-nephropathy-regions
#12
Josip Samardzic, Sefik Hasukic
Objectives: Endemic nephropathy (EN) is a chronic tubulointerstitial renal disease associated with increased incidence of upper urinary tract urothelial cancer (UTUC) occurring predominantly in geographically limited areas in villages along big Danube river. Based on results obtained by the research it is confirmed that aristolochic acid is causative agent of endemic nephropathy (EN). Aim: The aim of this study was to determine characteristics of UTUC in two endemic areas and analyze trends in 5-year period...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29408568/role-of-mri-targeted-biopsy-in-detection-of-prostate-cancer-harbouring-adverse-pathological-features-of-intraductal-carcinoma-and-invasive-cribriform-carcinoma
#13
Susan Prendeville, Mark Gertner, Manjula Maganti, Melania Pintilie, Nathan Perlis, Ants Toi, Andrew J Evans, Antonio Finelli, Theodorus H van der Kwast, Sangeet Ghai
PURPOSE: The aim of this study was to compare biopsy detection of intraductal (IDC) and cribriform (CR) pattern invasive prostate carcinoma (PCa) in mpMRI positive and negative regions of the prostate. MATERIAL AND METHODS: A prospectively maintained single institution database was queried to identify patients who underwent mpMRI/US fusion targeted biopsy (MRI-TBx) and concurrent systematic sextant biopsy of MRI negative regions (SMN-Bx) between January 2013 and May 2016...
January 31, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29405907/replacing-surveillance-cystoscopy-with-urinary-biomarkers-in-followup-of-patients-with-non-muscle-invasive-bladder-cancer-patients-and-urologic-oncologists-perspectives
#14
Rashid K Sayyid, Abdallah K Sayyid, Zachary Klaassen, Karen Hersey, Hanan Goldberg, Nathan Perlis, Ardalanejaz Ahmad, Ricardo Leao, Thenappan Chandrasekar, Kamel Fadaak, Rabii Madi, Martha K Terris, Antonio Finelli, Robert J Hamilton, Girish S Kulkarni, Alexandre R Zlotta, Neil E Fleshner
INTRODUCTION: Urinary biomarkers are being developed to detect bladder cancer recurrence/progression in patients with non-muscle invasive bladder cancer (NMIBC). We conducted a questionnaire-based study to determine what diagnostic accuracy and cost would such test(s) need for both patients and urologic oncologists to comfortably forgo surveillance cystoscopy in favor of these tests. METHODS: Surveys were administered to NMIBC patients at followup cystoscopy visit and to physician members of the Society of Urologic Oncology...
February 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29399302/laser-application-in-iran-urology-a-narrative-review
#15
REVIEW
Mohammad Reza Razzaghi, Morteza Fallah Karkan, Saleh Ghiasy, Babak Javanmard
The usage of laser in medicine is not recent, and its history in urology goes back to 40 years ago. For the last 2 decades, common uses of laser have been treatments of subjects with urolithiasis, bladder tumors, benign prostatic enlargement, lesions of the genitalia and urinary tract strictures. To evaluate laser application in urology in Iran, we reviewed all of the Iranian literature on the topic. This study was designed to retrieve all studies on laser application in urology in Iran, regardless of publication status or language, covering years 1990-2017...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29399194/characterization-of-the-t-cell-receptor-repertoire-by-deep-t-cell-receptor-sequencing-in-tissues-from-patients-with-prostate-cancer
#16
Song Liu, Weibing Pan, Zhiqiang Cheng, Guoping Sun, Peng Zhu, Franky Chan, Yunlong Hu, Xinzhou Zhang, Yong Dai
Prostate cancer (PC) is the most prevalent urological cancer in men. T cells serve a central role in the cancer's immunological microenvironment. In the present study, we applied multiplex PCR and Illumina next-generation sequencing to study the clonal diversity of the T-cell receptor (TCR) repertoire in cancer tissues and paracancer tissues from patients with PC. It was found that the TCR repertoire in the PC samples had a notably more skewed clonotype composition, with a greater number of highly expanded clones (HECs) compared with the prostate paracancer samples...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29397619/-consensus-of-chinese-experts-on-the-application-of-molecular-imaging-targeting-prostate-specific-membrane-antigen-in-prostate-cancer-patients
#17
(no author information available yet)
Recently, prostate cancer has become the most common male urological cancer worldwide. However, it was difficult for the currently widely available imaging modalities to precisely diagnose this disease. With the development of nuclear medical technology, molecular imaging targeting prostate specific membrane antigen has been introduced into China. To promote the standardization of this imaging modality, the experts consensus was published by Chinese Anticancer Association Genitourinary Oncology Committee and recommendations for its application in the diagnosis and treatment of prostate cancer were attached, which would be helpful for doctors who are conducting or preparing for this examination...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29396283/urological-survivorship-issues-among-adolescent-boys-and-young-men-who-are-cancer-survivors
#18
REVIEW
Troy Sukhu, Sherry Ross, R Matthew Coward
BACKGROUND: Urological survivorship issues encompass an area that may potentially be overlooked after treatment of childhood cancer in adolescent boys and young men. Side effects of cancer therapy may include subsequent development of erectile dysfunction (ED), hypogonadism, and infertility in adulthood. AIM: The purpose of this review is to focus on the etiology and prevalence of the range of sexual and gonadal dysfunction in adolescent boys and young men who are cancer survivors, while discussing current recommendations for evaluation and treatment...
January 27, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29394656/-a-case-of-appendiceal-mucinous-adenocarcinoma-detected-with-a-bladder-tumor
#19
Shinji Tsutsumi, Akihiko Murata, Yoichi Yamauchi, Kensuke Okano, Hiroshi Yokoyama, Akitoshi Kimura, Yoshiya Ishizawa, Minoru Umehara, Masashi Kato, Naoki Hashimoto, Yutaka Umehara, Shinsuke Nishikawa, Kenichi Takahashi, Takayuki Morita
A 74-year-oldwoman hadconsultedthe department of urology in our hospital because of microscopic hematuria. Cystoscopy revealeda urinary bladder tumor, suspectedas an adenocarcinoma basedon biopsy. MRI showeda cystic tumor of the appendix with vesical fistula; therefore, she underwent an operation with a diagnosis of appendiceal cancer invading the urinary bladder. During the operation, we found that the appendix sunk into the urinary bladder with right adnexa. Therefore, we performed ileocecal resection, partial resection of the urinary bladder, and right adnexectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393997/a-multicentre-integration-of-a-computer-led-follow-up-in-surgical-oncology-is-valid-and-safe
#20
Hesham Salem, Giacomo Caddeo, Jon McFarlane, Kunjan Patel, Lynda Cochrane, Daniele Soria, Mike Henley, Jonathan Lund
BACKGROUND: Prostate cancer (CaP) has a rising number of patients requiring routine follow up. In this study, we aimed to test a computer led follow up service for prostate cancer in two UK hospitals. The testing aimed to validate the computer Expert system in making clinical decisions according to the individual patient's clinical need. The valid model should accurately identify patients with disease recurrence or treatment failure based on their blood test and clinical picture. METHODS: A clinical decision support system (CDSS) was developed from European (EAU) and national (NICE) guidelines along with knowledge acquired from Urologists...
February 2, 2018: BJU International
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