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invasive group a streptococcus

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https://www.readbyqxmd.com/read/29454032/basal-polarization-of-the-immune-responses-to-streptococcus-agalactiae-susceptible-and-resistant-tilapia-oreochromis-niloticus
#1
Jiajie Zhu, Xi Gan, Qiuwei Ao, Xiashuang Shen, Yun Tan, Ming Chen, Yongju Luo, Hui Wang, Hesheng Jiang, Chao Li
One of the highest priority areas for improvement is the development of effective strategies for decreasing disease mortality levels in aquaculture production, a better understanding of the components of the fish immune system and their functions in the context of pathogen invasion is needed. Tilapia is the most common fish in South China, and Streptococcus agalactiae has become the most serious disease problem for tilapia industry in China. Here, we profiled gene expression differences between tilapia differing in their susceptibility to S...
February 14, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29444837/whole-genome-sequence-analysis-of-streptococcus-pneumoniae-strains-that-cause-hospital-acquired-pneumonia-infections
#2
Bin Chang, Masatomo Morita, Ken-Ichi Lee, Makoto Ohnishi
Streptococcus pneumoniae colonizes the nasopharyngeal mucus in healthy individuals and can cause otitis media, pneumonia, and invasive pneumococcal diseases. In this study, we analyzed the S. pneumoniae strains that caused 19 pneumonia episodes in long-term inpatients with severe underlying disease in a hospital during a period of 14 months (from January 2014 to February 2015). Serotyping and whole genome sequencing analyses revealed that 18 of the 19 pneumonia cases were caused by S. pneumoniae strains belonging to 3 genetically distinct groups: clonal complex (CC) 9999, sequence type (ST) 282, and ST166...
February 14, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29435555/opioid-analgesic-use-and-risk-for-invasive-pneumococcal-diseases-a-nested-case-control-study
#3
Andrew D Wiese, Marie R Griffin, William Schaffner, C Michael Stein, Robert A Greevy, Edward F Mitchel, Carlos G Grijalva
Background: Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, the clinical effects of prescription opioid use on infection risk among humans are unknown. Objective: To test the hypothesis that prescription opioid use is an independent risk factor for invasive pneumococcal disease (IPD). Design: Nested case-control study. Setting: Tennessee Medicaid database linked to Medicare and Active Bacterial Core surveillance system databases (1995 to 2014)...
February 13, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29420161/economic-evaluation-of-pneumococcal-vaccines-for-adults-aged-over-50-years-in-belgium
#4
Lander Willem, Adriaan Blommaert, Germaine Hanquet, Nancy Thiry, Joke Bilcke, Heidi Theeten, Jan Verhaegen, Herman Goossens, Philippe Beutels
Streptococcus pneumoniae causes a high disease burden including pneumonia, meningitis and septicemia. Both a polysaccharide vaccine targeting 23 serotypes (PPV23) and a 13-valent conjugate vaccine (PCV13) are indicated for persons aged over 50 years. We developed and parameterized a static multi-cohort model to estimate the incremental cost-effectiveness and budget-impact of these vaccines at different uptake levels. Using three different vaccine efficacy scenarios regarding non-invasive pneumococcal pneumonia and extensive uni- and multivariate sensitivity analyses, we found a strong preference for PPV23 over PCV13 in all age groups at willingness to pay levels below €300 000 per quality adjusted life year (QALY)...
February 8, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29416049/protective-effect-of-group-b-streptococcus-type-iii-polysaccharide-conjugates-against-maternal-colonization-ascending-infection-and-neonatal-transmission-in-rodent-models
#5
Emiliano Chiarot, Angela Spagnuolo, Silvia Maccari, Eleonora Naimo, Alessandra Acquaviva, Raffaella Cecchi, Bruno Galletti, Monica Fabbrini, Elena Mori, Paolo Ruggiero, Guido Grandi, Maria Rita Fontana, Giuliano Bensi, Immaculada Margarit
Group B Streptococcus (GBS) is a normal inhabitant of recto-vaginal mucosae in up to 30% of healthy women. Colonization is a major risk factor for perinatal infection which can lead to severe complications such as stillbirth and neonatal invasive disease. Intra-partum antibiotic prophylaxis in colonized women is a safe and cost-effective preventive measure against early-onset disease in the first days of life, but has no effect on late-onset manifestations or on early maternal infection. Maternal immunization with capsular polysaccharide-based vaccines shows promise for the prevention of both early-onset and late-onset neonatal infections, although ability to prevent maternal colonization and ascending infection has been less studied...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29408951/malaria-coinfections-in-febrile-pediatric-inpatients-a-hospital-based-study-from-ghana
#6
Benedikt Hogan, Daniel Eibach, Ralf Krumkamp, Nimako Sarpong, Denise Dekker, Benno Kreuels, Oumou Maiga-Ascofaré, Kennedy Gyau Boahen, Charity Wiafe Akenten, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, Jürgen May
Background: The epidemiology of pediatric febrile illness is shifting in sub-Saharan Africa, but malaria remains a major cause of childhood morbidity and mortality. The present study describes causes of febrile illness in hospitalized children in Ghana and aims to determine the burden of malaria coinfections and their association with parasite densities. Methods: In a prospective study, children (aged ≥30 days and ≤15 years) with fever ≥38.0°C were recruited after admission to the pediatric ward of a primary hospital in Ghana...
February 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29405142/distribution-of-different-genes-responsible-for-invasive-characteristics-detection-of-point-mutations-in-capsular-gene-wcha-and-biofilm-production-among-the-invasive-and-non-invasive-isolates-of-streptococcus-pneumoniae
#7
James John, Kripa Shanker Kasudhan, Reba Kanungo, Savitri Sharma, Vaishali Dohe, K Prashanth
BACKGROUND: Streptococcus pneumoniae continues to cause morbidity and mortality across the globe, with developing countries bearing the brunt of the disease. It is mainly responsible for meningitis, pneumonia and septicaemia primarily in children, elderly and immunocompromised persons. Colonisation and persistence in the human nasopharynx occur during early childhood, and it appears to be prerequisite for invasive pneumococcal disease (IPD). Factors that help in persistent colonisation and subsequent invasion are ill understood...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29399583/status-of-group-b-streptococcal-vaccine-development
#8
Shun Mei Lin, Yong Zhi, Ki Bum Ahn, Sangyong Lim, Ho Seong Seo
Streptococcus agalactiae (group B streptococcus, GBS) is a leading causal organism of neonatal invasive diseases and severe infections in the elderly. Despite significant advances in the diagnosis and treatment of GBS infections and improvement in personal hygiene standards, this pathogen is still a global health concern. Thus, an effective vaccine against GBS would augment existing strategies to substantially decrease GBS infection. In 2014, World Health Organization convened the first meeting for consultation on GBS vaccine development, focusing on the GBS maternal immunization program, which was aimed at reducing infections in neonates and young infants worldwide...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29398277/maternal-immunization-against-group-b-streptococcus-world-health-organization-research-and-development-technological-roadmap-and-preferred-product-characteristics
#9
REVIEW
Johan Vekemans, Vasee Moorthy, Martin Friede, Mark R Alderson, Ajoke Sobanjo-Ter Meulen, Carol J Baker, Paul T Heath, Shabir A Madhi, Kirsty Mehring-Le Doare, Samir K Saha, Stephanie Schrag, David C Kaslow
Group B streptococcus, found in the vagina or lower gastrointestinal tract of about 10-40% of women of reproductive age, is a leading cause of early life invasive bacterial disease, potentially amenable to prevention through maternal immunization during pregnancy. Following a consultation process with global stakeholders, the World Health Organization is herein proposing priority research and development pathways and preferred product characteristics for GBS vaccines, with the aim to facilitate and accelerate vaccine licensure, policy recommendation for wide scale use and implementation...
February 2, 2018: Vaccine
https://www.readbyqxmd.com/read/29378883/the-endopeptidase-pepo-regulates-the-speb-cysteine-protease-and-is-essential-for-the-virulence-of-invasive-m1t1-streptococcus-pyogenes
#10
Stephan Brouwer, Amanda J Cork, Cheryl-Lynn Y Ong, Timothy C Barnett, Nicholas P West, Kevin S McIver, Mark J Walker
Streptococcus pyogenes (Group A Streptococcus, GAS) causes a wide range of human infections. The pathogenesis of GAS infections is dependent on the temporal expression of numerous secreted and surface-associated virulence factors that interact with host proteins. Streptococcal pyrogenic exotoxin B (SpeB) is one of the most extensively studied toxins produced by GAS, and the coordinate growth phase-dependent regulation of speB expression is linked to disease severity phenotypes. Here we identified the endopeptidase PepO as a novel growth phase-dependent regulator of SpeB in the invasive GAS M1-serotype strain 5448...
January 29, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29377225/pathogenic-mechanisms-of-invasive-group-a-streptococcus-gas-infections-by-influenza-virus-gas-superinfection
#11
REVIEW
Shigefumi Okamoto, Satoshi Nagase
Group A Streptococcus (GAS) are pathogenic bacteria of the genus Streptococcus, and cause severe invasive GAS infections that comprise a wide range of diverse diseases, including acute respiratory distress syndrome, renal failure, toxic shock-like syndrome (TSLS), sepsis, cellulitis, and necrotizing fasciitis. The essential virulence, infected host, and external environmental factors required for invasive GAS infections still have not known. We demonstrated that superinfection with influenza virus and GAS induced invasive GAS infections in a mouse model, and then several investigators reported clinical cases of invasive GAS infections secondary to influenza virus infection in Japan, the United States, Canada, the United Kingdom, China, and others...
January 27, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29373267/mediastinal-subcutaneous-and-multiple-muscular-abscesses-caused-by-group-b-streptococcus-serotype-viii-in-a-type-2-diabetes-mellitus-patient
#12
Yuka Omura, Yoshiki Kusama, Noriko Takeuchi, Naruhiko Ishiwada
We report a case of mediastinal subcutaneous and multiple muscular abscesses caused by group B streptococcus serotype VIII in a type 2 diabetes mellitus patient. The patient arrived at the hospital with the chief complaint of immobility, and blood examination results suggested an acute infection and poorly controlled diabetes mellitus. Group B streptococcal bacteria were cultured from the patient's blood, and identified as serotype VIII upon further analysis. The patient recovered without any sequelae after percutaneous drainage, antibiotic therapy, and intensive glycemic control...
January 17, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29371153/pilus-encoding-islets-in-s-agalactiae-and-its-association-with-antibacterial-resistance-and-serotype-distribution
#13
Farzaneh Khodaei, Mohammad Najafi, Alka Hasani, Enayatollah Kalantar, Esmail Sharifi, Abbas Amini, Mohammad Aghazadeh
Group B Streptococcus (GBS) is a versatile organism which uses multiple virulence factors which bind to the surface of epithelial cells. Pili are one of virulence factors detected in recent years. A total of 90 isolates were collected from invasive and non-invasive isolates among adults throughout 2014-2015. Isolates were serotyped at molecular level based on capsular polysaccharide (cps) serotyping and analyzed for pilus island profiles, scpB gene, and hvgA gene presence. Isolates were subjected to antimicrobial susceptibility towards penicillin, tetracycline, erythromycin, clindamycin, moxifloxacin, levofloxacin, and vancomycin by disk diffusion method and MICs for erythromycin and clindamycin were determined by broth dilution methods...
January 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29370285/severe-community-acquired-pneumonia-characteristics-and-prognostic-factors-in-ventilated-and-non-ventilated-patients
#14
Miquel Ferrer, Chiara Travierso, Catia Cilloniz, Albert Gabarrus, Otavio T Ranzani, Eva Polverino, Adamantia Liapikou, Francesco Blasi, Antoni Torres
BACKGROUND: Patients with severe community-acquired pneumonia (SCAP) and life-threatening acute respiratory failure may require invasive mechanical ventilation (IMV). Since use of IMV is often associated with significant morbidity and mortality, we assessed whether patients invasively ventilated would represent a target population for interventions aimed at reducing mortality of SCAP. METHODS: We prospectively recruited consecutive patients with SCAP for 12 years...
2018: PloS One
https://www.readbyqxmd.com/read/29349940/etiology-of-invasive-bacterial-infections-in-immunocompetent-children-in-korea-2006-2010-a-retrospective-multicenter-study
#15
Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo Kim, Su Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29337246/tlr3-gene-in-japanese-sea-perch-lateolabrax-japonicus-molecular-cloning-characterization-and-expression-analysis-after-bacterial-infection
#16
Pengfei Wang, Chao Zhao, Chengyang Wang, Sigang Fan, Lulu Yan, Lihua Qiu
Toll-like receptors (TLRs) play important roles in fish innate immune and are involved in the defense process of bacteria invasion. In the present study, the full-length cDNA of TLR3 from the sea perch, Lateolabrax japonicus, was cloned and characterized. The full length of LjTLR3 cDNA was 3265 bp including an open reading frame of 2679 bp encoding a peptide of 922 amino acids. Tissues distribution analysis indicated that LjTLR3 showed a tissue-specific variation with high expression in spleen, head-kidney and liver...
January 11, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29317173/identification-of-a-proteomic-biomarker-associated-with-invasive-st1-serotype-vi-group-b-streptococcus-by-maldi-tof-ms
#17
Hsiao-Chuan Lin, Jang-Jih Lu, Lee-Chung Lin, Cheng-Mao Ho, Kao-Pin Hwang, Yu-Ching Liu, Chao-Jung Chen
BACKGROUND: Group B Streptococcus (GBS) is an important invasive pathogen in neonates, pregnant women and the elderly. Serotype VI GBS, which has been rarely reported globally, has emerged as a significant pathogen in Asia. However, traditional serologic latex agglutination (LA) methods may fail to type isolates that lack of or low expression of CPS. METHODS: A total of 104 GBS strains were analyzed by MALDI-TOF MS. Multiplex PCR and multilocus sequence typing (MLST) were also performed to confirm their strains...
December 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29310577/epidemiology-of-invasive-group-b-streptococcal-disease-in-infants-from-urban-area-of-south-china-2011-2014
#18
Xiaoshan Guan, Xiaoping Mu, Wenjing Ji, Chunlei Yuan, Ping He, Lian Zhang, Yanfen Huang, Juan Li, Jianfeng Chen, Huamin Zhong, Shuyin Pang, Nan Tan, Qiulian Deng, Kankan Gao, Yu-Ping Huang, Chien-Yi Chang, Haiying Liu
BACKGROUND: Group B Streptococcus (GBS) is a leading cause of morbidity and mortality in infants in both developed and developing countries. To our knowledge, only a few studies have been reported the clinical features, treatment and outcomes of the GBS disease in China. The severity of neonatal GBS disease in China remains unclear. Population-based surveillance in China is therefore required. METHODS: We retrospectively collected data of <3 months old infants with culture-positive GBS in sterile samples from three large urban tertiary hospitals in South China from Jan 2011 to Dec 2014...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29284415/streptococcus-agalactiae-infective-endocarditis-complicated-by-multiple-mycotic-hepatic-aneurysms-and-massive-splenic-infarction-a-case-report
#19
Pietro Achilli, Angelo Guttadauro, Paolo Bonfanti, Sabina Terragni, Luca Fumagalli, Ugo Cioffi, Francesco Gabrielli, Matilde De Simone, Marco Chiarelli
BACKGROUND: The burden of disease caused by Streptococcus agalactiae has increased significantly among older adults in the last decades. Group B streptococcus infection can be associated with invasive disease and severe clinical syndromes, such as meningitis and endocarditis. CASE PRESENTATION: We present the case of a 56-year-old man who developed multiple mycotic aneurysms of the right hepatic artery and massive splenic infarction as rare complications of Streptococcus agalactiae infective endocarditis...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29282118/biofilm-production-and-other-virulence-factors-in-streptococcus-spp-isolated-from-clinical-cases-of-bovine-mastitis-in-poland
#20
Edyta Kaczorek, Joanna Małaczewska, Roman Wójcik, Andrzej Krzysztof Siwicki
BACKGROUND: Mastitis is a common disease in dairy cattle throughout the world and causes considerable economic losses each year. An important aetiological agent of this disease is bacteria of the genus Streptococcus; hence, exploring the mechanisms of virulence in these bacteria is an extremely important step for the development of effective prevention programmes. The purpose of our study was to determine the ability to produce biofilm and the occurrence of selected invasiveness factors among bacteria of the genus Streptococcus isolated from cattle with the clinical form of mastitis in northeastern Poland...
December 28, 2017: BMC Veterinary Research
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