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invasive group a streptococcus

Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P Czarkowski
PURPOSE of the STUDY: The aim of the study is to assess epidemiological situation of infectious and parasitic diseases in Poland in 2014, and an indication of the potential health risks from communicable diseases occurring in other areas of the globe. MATERIAL AND METHODS: This paper is a summary of the analysis and evaluation of the results of epidemiological surveillance of infectious diseases in Poland in 2014, and those elements of European and global epidemiological background, which in this period had an impact on the epidemiological situation in Poland or constituted a threat...
2016: Przegla̧d Epidemiologiczny
Alefiya Neemuchwala, Sarah Teatero, Taryn B T Athey, Allison McGeer, Nahuel Fittipaldi
We report several cases of recombination events leading to capsular switching among sequence type (ST) 1 group B Streptococcus strains. These strains otherwise shared a common genome backbone with serotype V ST1 strains. However, the genomes of ST1 serotype V strains and those of serotypes VI, VII, and VIII strains differed substantially.
November 2016: Emerging Infectious Diseases
Sarah Teatero, Patricia Ferrieri, Nahuel Fittipaldi
To further understand the emergence of serotype IV group B Streptococcus (GBS) invasive disease, we used whole-genome sequencing to characterize 3 sequence type 468 strains isolated from neonates in Minnesota, USA. We found that strains of tetracycline-resistant sequence type 468 GBS have acquired virulence genes from a putative clonal complex 17 GBS donor by recombination.
November 2016: Emerging Infectious Diseases
Priyanka Rajendram, Win Mar Kyaw, Yee Sin Leo, Hanley Ho, Wen Kai Chen, Raymond Lin, De Partha Pratim, Hishamuddin Badaruddin, Brenda Ang, Timothy Barkham, Angela Chow
An outbreak of invasive group B Streptococcus (GBS) disease occurred in Singapore in mid-2015. We conducted a case-control study of 22 adults with invasive GBS infections during June 21-November 21, 2015. Consumption of raw fish was strongly associated with invasive sequence type 283 infections, but not with non-sequence type 283 infections.
November 2016: Emerging Infectious Diseases
Morven S Edwards, Marcia A Rench, C Daniela Rinaudo, Monica Fabbrini, Giovanna Tuscano, Giada Buffi, Erika Bartolini, Stefano Bonacci, Carol J Baker, Immaculada Margarit
Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis...
November 2016: Emerging Infectious Diseases
Noha Samir Kabil, Amira Saad Badran, Mariem Osama Wassel
BACKGROUND: Antibacterial restorations can increase the success rate of minimum invasive dentistry especially in young permanent molars with deep carious lesions as an attempt to preserve maximum dental structure and avoid pulp exposure. Further research is warranted to evaluate different antibacterial agents. OBJECTIVES: This study aimed to evaluate the efficacy of adding chlorhexidine gluconate (CHX) or aqueous miswak (Salvadora persica) extract on the clinical performance and in vivo antibacterial activity of conventional anhydrous glass ionomer cement (GIC)...
October 21, 2016: International Journal of Paediatric Dentistry
Jia-Yun C Tsai, Jacelyn M S Loh, Fiona Clow, Natalie Lorenz, Thomas Proft
Group A Streptococcus (GAS), or Streptococcus pyogenes, is a human pathogen that causes diseases ranging from skin and soft tissue infections to severe invasive diseases, such as toxic shock syndrome. Each GAS strain carries a particular pilus type encoded in the variable fibronectin-binding, collagen-binding, T antigen (FCT) genomic region. Here we describe the functional analysis of the serotype M2 pilus encoded in the FCT-6 region. We found that, in contrast to other investigated GAS pili, the ancillary pilin 1 lacks adhesive properties...
October 14, 2016: Molecular Microbiology
Constantin Hays, Mathilde Louis, Céline Plainvert, Nicolas Dmytruk, Gérald Touak, Patrick Trieu-Cuot, Claire Poyart, Asmaa Tazi
Group B Streptococcus (GBS) is the leading cause of neonatal invasive infections and an emerging pathogen in the elderly. Our objectives were to describe the evolution of GBS resistance to antibiotics in France and to investigate the emergence of fluoroquinolone (FQ) resistant isolates. A total of 8,757 unrelated GBS isolates were collected and tested for antibiotic susceptibility from 2007 and 2014 according to EUCAST recommendations. All isolates were susceptible to penicillin G, amoxicillin, and vancomycin...
October 10, 2016: Antimicrobial Agents and Chemotherapy
Karin Holm, Steffen Bank, Hanne Nielsen, Lena Hagelskjær Kristensen, Jørgen Prag, Anders Jensen
Fusobacterium necrophorum is a gram-negative anaerobic bacterium that is the causative agent of the invasive disease Lemierre's syndrome. In addition, it is also associated with peritonsillar abscess formation and otitis media in small children. Recent research has shown that F. necrophorum may be involved in pharyngotonsillitis especially in adolescent and young adults and that it may be the second most common bacterial cause of pharyngotonsillitis after Streptococcus pyogenes (Group A streptococci). Peritonsillar abscesses and Lemierre's syndrome due to F...
September 28, 2016: Anaerobe
Binghuai Lu, Xingchun Chen, Junrui Wang, Duochun Wang, Ji Zeng, Yi Li, Dong Li, Fengxia Zhu, Yanchao Cui, Lei Huang
Group B streptococcus (GBS) is an increasing pathogen threat to newborns and adults with immunodepressive diseases. Here, a total of 193 GBS, including 51 invasive and 142 noninvasive isolates, were collected from the patients with infections in 7 tertiary hospitals from 5 cities in China during the year 2008 to 2015. The strains of GBS were characterized by classical and molecular techniques for capsular polysaccharide serotyping, genes for pilus island (PI) and α-like protein (alp), and antibiotic resistance profiling...
August 28, 2016: Diagnostic Microbiology and Infectious Disease
Yasuko Kamiya, Tadao Hasegawa, Yasuhiko Takegami, Kazuhiro Horiba, Shotaro Ando, Yuka Torii, Hiroyuki Kidokoro, Taichi Kato, Jun Natsume, Jun-Ich Kawada, Yoshinori Ito
Primary abscess of the iliopsoas muscle in children is uncommon, especially due to Streptococcus pyogenes (group A streptococcus: GAS), which causes a variety of diseases ranging from pharyngitis to invasive life-threatening infection. We present primary iliopsoas abscess in a nine-year-old boy presenting with fever, mild disturbance of consciousness, limp, and pain in the right loin. Magnetic resonance imaging and isolation of GAS from both blood and abscess samples led us to the confirmative diagnosis. The patient recovered after treatment comprising drainage and intravenous antibiotics...
September 27, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Sonwabile Dzanibe, Peter V Adrian, Sheila Z Kimaro Mlacha, Shabir A Madhi
Group B Streptococcus (GBS) is a major cause of invasive disease in young infants and also in older immunocompromised individuals, including HIV-infected persons. We compared naturally acquired antibody titres to GBS polysaccharide and surface protein antigens in HIV-uninfected and HIV-infected children aged 4-7 years. A multiplex Luminex immunoassay was used to measure IgG concentrations against GBS capsular polysaccharides (CPS) for serotypes Ia, Ib, III and V; and also extracellular localizing proteins which included cell-wall anchored proteins: Fibrinogen binding surface Antigen (FbsA), GBS Immunogenic Bacterial Adhesin (BibA), Surface immunogenic protein (Sip), gbs0393, gbs1356, gbs1539, gbs0392; and lipoproteins gbs0233, gbs2106 and Foldase PsrA...
October 17, 2016: Vaccine
Margaret Ip, Irene Ang, Kitty Fung, Veranja Liyanapathirana, Ming Jing Luo, Raymond Lai
We describe a hypervirulent clone of group B Streptococcus serotype III, subtype 4, sequence type 283, that caused invasive disease with a predilection for meningitis in Hong Kong during 1993-2012. The organism is associated with high mortality and increased summer prevalence and is linked to diseased fish from freshwater fish farms.
October 2016: Emerging Infectious Diseases
A Lev-Sagie, D Hochner-Celnikier, D Stroumsa, A Khalaileh, H Daum, A E Moses
Group A streptococcus (GAS) is a rare but serious cause of postpartum and gynecological infections. There are no follow-up or prophylaxis guidelines for women with previous GAS genital infection. We aimed to evaluate the incidence of long-term gynecological carrier state in patients with a history of genital GAS infection. This is a prospective study of women who had a genital GAS infection and were followed for 1 year from the date of isolation. Cultures were obtained every 3-4 months. As a control group, women with no previously documented GAS infection were screened for GAS...
September 14, 2016: European Journal of Clinical Microbiology & Infectious Diseases
Beth A Bachert, Soo J Choi, Paul R LaSala, Tiffany I Harper, Dudley H McNitt, Dylan T Boehm, Clayton C Caswell, Pawel Ciborowski, Douglas R Keene, Anthony R Flores, James M Musser, Flavia Squeglia, Daniela Marasco, Rita Berisio, Slawomir Lukomski
The streptococcal collagen-like proteins 1 and 2 (Scl1 and Scl2) are major surface adhesins that are ubiquitous among group A Streptococcus (GAS). Invasive M3-type strains, however, have evolved two unique conserved features in the scl1 locus: (i) an IS1548 element insertion in the scl1 promoter region and (ii) a nonsense mutation within the scl1 coding sequence. The scl1 transcript is drastically reduced in M3-type GAS, contrasting with a high transcription level of scl1 allele in invasive M1-type GAS. This leads to a lack of Scl1 expression in M3 strains...
2016: Frontiers in Cellular and Infection Microbiology
Haoqin Jiang, Mingliang Chen, Tianming Li, Hong Liu, Ye Gong, Min Li
Streptococcus agalactiae, a colonizing agent in pregnant women and the main cause of neonatal sepsis and meningitis, has been increasingly associated with invasive disease in nonpregnant adults. We collected a total of 87 non-repetitive S. agalactiae isolates causing community-acquired (CA) and hospital-acquired (HA) infections in nonpregnant adults from a teaching hospital in Shanghai between 2009 and 2013. We identified and characterized their antibiotic resistance, sequence type (ST), serotype, virulence, and biofilm formation...
2016: Frontiers in Microbiology
Wenchao Feng, Mengyao Liu, Daniel G Chen, Rossana Yiu, Ferric C Fang, Benfang Lei
Group A Streptococcus (GAS) causes diverse infections ranging from common pharyngitis to rare severe invasive infections. Invasive GAS isolates can have natural mutations in the virulence regulator CovRS, which result in enhanced expression of multiple virulence genes, suppressed the expression of the protease SpeB, and increased virulence. It is believed that CovRS mutations arise during human infections with GAS carrying wild-type CovRS and are not transmissible. CovRS mutants of invasive GAS of the emm1 genotype arise readily during experimental infection in mice...
2016: PloS One
Jesus Eraso, Randall J Olsen, Stephen B Beres, Priyanka Kachroo, Adeline R Porter, Waleed Nasser, Paul E Bernard, Frank DeLeo, James M Musser
To obtain new information about Streptococcus pyogenes intrahost genetic variation during invasive infection, we sequenced the genome of 2,954 serotype M1 strains recovered from a nonhuman primate experimental model of necrotizing fasciitis. A total of 644 strains (21.8%) acquired polymorphisms relative to the input parental strain. The fabT gene encoding a transcriptional regulator of fatty acid biosynthesis genes contained 54.5% of these changes. The great majority of polymorphisms were predicted to deleteriously alter FabT function...
September 6, 2016: Infection and Immunity
Nicholas J Andreas, Asmaa Al-Khalidi, Mustapha Jaiteh, Edward Clarke, Matthew J Hyde, Neena Modi, Elaine Holmes, Beate Kampmann, Kirsty Mehring Le Doare
Group B Streptococcus (GBS) infection is a major cause of morbidity and mortality in infants. The major risk factor for GBS disease is maternal and subsequent infant colonisation. It is unknown whether human milk oligosaccharides (HMOs) protect against GBS colonisation. HMO production is genetically determined and linked to the Lewis antigen system. We aimed to investigate the association between HMOs and infant GBS colonisation between birth and postnatal day 90. Rectovaginal swabs were collected at delivery, as well as colostrum/breast milk, infant nasopharyngeal and rectal swabs at birth, 6 days and days 60-89 postpartum from 183 Gambian mother/infant pairs...
August 2016: Clinical & Translational Immunology
Edmondo Campisi, Roberto Rosini, Wenjing Ji, Silvia Guidotti, Maricarmen Rojas-López, Guozhu Geng, Qiulian Deng, Huamin Zhong, Weidong Wang, Haiying Liu, Cassandra Nan, Immaculada Margarit, C D Rinaudo
Neonatal invasive disease caused by group B Streptococcus (GBS) represents a significant public health care concern globally. However, data related to disease burden, serotype distribution, and molecular epidemiology in China and other Asian countries are very few and specifically relative to confined regions. The aim of this study was to investigate the genetic characteristics of GBS isolates recovered from neonates with invasive disease during 2013-2014 at Guangzhou and Changsha hospitals in southern mainland China...
2016: Frontiers in Microbiology
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