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invasive group a streptococcus

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https://www.readbyqxmd.com/read/28537550/household-transmission-of-invasive-group-a-streptococcus-infections-in-england-a-population-based-study-2009-2011-to-2013
#1
Rachel Mearkle, Maria Saavedra-Campos, Theresa Lamagni, Martine Usdin, Juliana Coelho, Vicki Chalker, Shiranee Sriskandan, Rebecca Cordery, Chas Rawlings, Sooria Balasegaram
Invasive group A streptococcal infection has a 15% case fatality rate and a risk of secondary transmission. This retrospective study used two national data sources from England; enhanced surveillance (2009) and a case management system (2011-2013) to identify clusters of severe group A streptococcal disease. Twenty-four household pairs were identified. The median onset interval between cases was 2 days (range 0-28) with simultaneous onset in eight pairs. The attack rate during the 30 days after first exposure to a primary case was 4,520 per 100,000 person-years at risk (95% confidence interval (CI): 2,900-6,730) a 1,940 (95% CI: 1,240-2,880) fold elevation over the background incidence...
May 11, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28531208/phylogenetic-analysis-of-emergent-streptococcus-pneumoniae-serotype-22f-causing-invasive-pneumococcal-disease-using-whole-genome-sequencing
#2
Walter H B Demczuk, Irene Martin, Linda Hoang, Paul Van Caeseele, Brigitte Lefebvre, Greg Horsman, David Haldane, Jonathan Gubbay, Sam Ratnam, Gregory German, Jennifer Daley Bernier, Lori Strudwick, Allison McGeer, George G Zhanel, Gary Van Domselaar, Morag Graham, Michael R Mulvey
Since implementation of the 13-valent polyvalent conjugate vaccine (PCV13) in Canada during 2010, the proportion of PCV13 serotypes causing invasive pneumococcal disease (IPD) has declined from 55% (n = 1492) in 2010 to 31% (n = 764) in 2014. A concurrent increase of non-PCV13 serotypes has occurred and 22F has become the most prevalent serotype in Canada increasing from 7% (n = 183) to 11% (n = 283). Core single nucleotide variant phylogenetic analysis was performed on 137 Streptococcus pneumoniae serotype 22F isolates collected across Canada from 2005-2015...
2017: PloS One
https://www.readbyqxmd.com/read/28529115/pneumococcal-infection-in-patients-with-systemic-lupus-erythematosus
#3
Juliet Schurder, Tiphaine Goulenok, Romain Jouenne, Antoine Dossier, Damien Van Gysel, Thomas Papo, Karim Sacre
OBJECTIVE: Our study aimed to analyze the risk factors associated with the occurrence and severity of pneumococcal infection (PI) in systemic lupus erythematosus (SLE) patients. METHODS: Medical records of all SLE patients admitted in our department from January 2005 to December 2014 were retrospectively reviewed. SLE Patients were separated in 2 groups according to whether they had PI or not. Medical records of all consecutive patients (with and without SLE) admitted in our department for PI over the same period of time were also reviewed...
May 18, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28520869/comparative-pathogenomic-characterization-of-a-non-invasive-serotype-m71-strain-streptococcus-pyogenes-ns53-reveals-incongruent-phenotypic-implications-from-distinct-genotypic-markers
#4
Yun-Juan Bao, Yang Li, Zhong Liang, Garima Agrahari, Shaun W Lee, Victoria A Ploplis, Francis J Castellino
The strains serotyped as M71 from group A Streptococcus are common causes of pharyngeal and skin diseases worldwide. Here we characterize the genome of a unique non-invasive M71 human isolate, NS53. The genome does not contain structural rearrangements or large-scale gene gains/losses, but encodes a full set of non-truncated known virulence factors, thus providing an ideal reference for comparative studies. However, the NS53 genome showed incongruent phenotypic implications from distinct genotypic markers. NS53 is characterized as an emm pattern D and FCT (fibronectin-collagen-T-antigen) type-3 strain, typical of skin tropic strains, but is phylogenetically close to emm pattern E strains with preference for both skin and pharyngeal infections...
May 17, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28515218/group-b-streptococcus-among-pregnant-women-and-newborns-in-mirzapur-bangladesh-colonization-vertical-transmission-and-serotype-distribution
#5
Samir K Saha, Zabed B Ahmed, Joyanta K Modak, Hakka Naziat, Shampa Saha, Mohammad A Uddin, Maksuda Islam, Abdullah H Baqui, Gary L Darmstadt, Stephanie J Schrag
Group B Streptococcus (GBS) infection is a leading cause of death in newborns in developed countries. Data on burden of GBS in Asian countries is lacking. This study aimed to understand i) rate of maternal recto-vaginal GBS carriage, ii) vertical transmission of GBS as determined by culturing ear, umbilicus and nasal swabs, and iii) distribution of GBS serotypes. This prospective observational study was conducted from September 2012 to November 2013 at Kumudini Hospital, a secondary level hospital, at Mirzapur, Bangladesh...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28502330/three-decades-of-follow-up-of-adults-after-recovery-from-invasive-pneumococcal-pneumonia
#6
Oluwadamilare O Ajayi, Nancy B Norton, Todd W Gress, Ronald J Stanek, Maurice A Mufson
BACKGROUND: Streptococcus pneumoniae infection is the most common cause of community-acquired pneumonia in adults. Invasive pneumococcal disease (IPD) carries a high case fatality rate. We investigated the lifespan of adults who recovered from IPD during a 32-year follow-up. MATERIALS AND METHODS: We determined whether adults discharged after an episode of IPD from hospitals affiliated with the Marshall University Joan C. Edwards School of Medicine in Huntington, West Virginia from 1983-2003 were alive on June 30, 2014...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28475781/2015-epidemic-of-severe-streptococcus-agalactiae-sequence-type-283-infections-in-singapore-associated-with-the-consumption-of-raw-freshwater-fish-a-detailed-analysis-of-clinical-epidemiological-and-bacterial-sequencing-data
#7
Shirin Kalimuddin, Swaine L Chen, Cindy T K Lim, Tse Hsien Koh, Thean Yen Tan, Michelle Kam, Christopher W Wong, Kurosh S Mehershahi, Man Ling Chau, Lee Ching Ng, Wen Ying Tang, Hishamuddin Badaruddin, Jeanette Teo, Anucha Apisarnthanarak, Nuntra Suwantarat, Margaret Ip, Matthew T G Holden, Li Yang Hsu, Timothy Barkham
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) has not been described as a foodborne pathogen. However, in 2015, a large outbreak of severe invasive sequence type (ST) 283 GBS infections in adults epidemiologically linked to the consumption of raw freshwater fish occurred in Singapore. We attempted to determine the scale of the outbreak, define the clinical spectrum of disease, and link the outbreak to contaminated fish. Methods: Time-series analysis was performed on microbiology laboratory data...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28470020/rapid-emergence-of-a-new-clone-impacts-the-population-at-risk-and-increases-the-incidence-of-type-emm89-group-a-streptococcus-invasive-disease
#8
Sarah Teatero, Brenda L Coleman, Stephen B Beres, Randall J Olsen, Christopher Kandel, Olivia Reynolds, Taryn B T Athey, James M Musser, Allison McGeer, Nahuel Fittipaldi
BACKGROUND: Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly described. METHODS: We used population-based iGAS surveillance data collected in metropolitan Toronto, Ontario, Canada during the period 2000-2014. We sequenced the genomes of 105 emm89 isolates representing all emm89 iGAS disease cases in the area during the period and 138 temporally matched emm89 iGAS isolates collected elsewhere in Ontario...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28462035/whole-genome-sequencing-of-group-a-streptococcus-development-and-evaluation-of-an-automated-pipeline-for-emmgene-typing
#9
Georgia Kapatai, Juliana Coelho, Steven Platt, Victoria J Chalker
Streptococcus pyogenes group A Streptococcus (GAS) is the most common cause of bacterial throat infections, and can cause mild to severe skin and soft tissue infections, including impetigo, erysipelas, necrotizing fasciitis, as well as systemic and fatal infections including septicaemia and meningitis. Estimated annual incidence for invasive group A streptococcal infection (iGAS) in industrialised countries is approximately three per 100,000 per year. Typing is currently used in England and Wales to monitor bacterial strains of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28459299/enhanced-nasopharyngeal-infection-and-shedding-associated-with-an-epidemic-lineage-of-emm3-group-a-streptococcus
#10
Baharak Afshar, Claire E Turner, Theresa Lamagni, Ken Smith, Ali Al-Shahib, Anthony Underwood, Matthew T G Holden, Androulla Efstratiou, Shiranee Sriskandan
Background A group A Streptococcus (GAS) lineage of genotype emm3, sequence type 15 (ST15) was associated with a six month upsurge in invasive GAS disease in the UK. The epidemic lineage (Lineage C) had lost two typical emm3 prophages, Φ315.1 and Φ315.2 associated with the superantigen ssa, but gained a different prophage (ΦUK-M3.1) associated with a different superantigen, speC and a DNAse spd1. Methods and Results The presence of speC and spd1 in Lineage C ST15 strains enhanced both in vitro mitogenic and DNAse activities over non-Lineage C ST15 strains...
May 1, 2017: Virulence
https://www.readbyqxmd.com/read/28447173/clinical-and-microbiological-features-associated-with-group-b-streptococcus-bone-and-joint-infections-france-2004-2014
#11
S Kernéis, C Plainvert, J-P Barnier, A Tazi, N Dmytruk, B Gislain, J Loubinoux, F El Sayed, V Cattoir, N Desplaces, V Vernet, P Morand, C Poyart
This study describes the clinical and microbiological features associated with group B Streptococcus (GBS) bone and joint infections (BJIs). It was a retrospective analysis of adult cases of GBS BJIs reported to the French National Reference Center for Streptococci from January 2004 to December 2014. Clinical data and GBS molecular characteristics are reported. Strains were collected from 163 patients. The most frequent comorbidities were: solid organ cancer (n = 21, 21%) and diabetes mellitus (n = 20, 20%)...
April 26, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28420662/outcome-of-a-screening-programme-for-the-prevention-of-neonatal-invasive-early-onset-group-b-streptococcus-infection-in-a-uk-maternity-unit-an-observational-study
#12
G Gopal Rao, G Nartey, T McAree, A O'Reilly, S Hiles, T Lee, S Wallace, R Batura, P Khanna, H Abbas, C Tilsed, R Nicholl, T Lamagni, P Bassett
BACKGROUND: Against a background of failure to prevent neonatal invasive early-onset group B Streptococcus infections (GBS) in our maternity unit using risk-based approach for intrapartum antibiotic prophylaxis, we introduced an antenatal GBS carriage screening programme to identify additional women to target for prophylaxis. OBJECTIVES: To describe the implementation and outcome of an antepartum screening programme for prevention of invasive early-onset GBS infection in a UK maternity unit...
April 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28417006/first-report-of-serotype-23b-streptococcus-pneumoniae-isolated-from-an-adult-patient-with-invasive-infection-in-japan
#13
A Takamatsu, M Kawaguchiya, B Chang, M Ito, Y Hirano, S Katsuta, S Matsuzaka, Y Serizawa, N Kobayashi
Serotype 23B Streptococcus pneumoniae was isolated from a 67-year-old Japanese patient with meningitis. This isolate was susceptible to penicillin G, while genotyped as gPISP with a mutation in a penicillin-binding motif in PBP2b. The 23B isolate was assigned to ST11996 that is related to CC439, a dominant group among serotype 23B.
May 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28416607/human-milk-oligosaccharides-inhibit-growth-of-group-b-streptococcus
#14
Ann E Lin, Chloe A Autran, Alexandra Szyszka, Tamara Escajadillo, Mia Huang, Kamil Godula, Anthony R Prudden, Geert-Jan Boons, Amanda L Lewis, Kelly S Doran, Victor Nizet, Lars Bode
Streptococcus agalactiae (group B Streptococcus; GBS) is a leading cause of invasive bacterial infections in newborns, typically acquired vertically during childbirth secondary to maternal vaginal colonization. Human milk oligosaccharides (HMOs) have important nutritional and biological activities that guide development of the infant's immune system and shape the composition of normal gut microbiota. In this manner, HMOs help protect against pathogen colonization and reduce risk of infection. In the course of our studies of HMO-microbial interactions, we unexpectedly uncovered a novel HMO property to directly inhibit the growth of GBS, independent of host immunity...
April 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28401320/the-virulence-factors-of-group-a-streptococcus-strains-isolated-from-invasive-and-non-invasive-infections-in-polish-and-german-centres-2009-2011
#15
M Strus, P B Heczko, E Golińska, A Tomusiak, A Chmielarczyk, M Dorycka, M van der Linden, A Samet, A Piórkowska
Streptococcus pyogenes (GAS) is one of the major human pathogenic bacteria that cause a wide range of diseases. Currently, increased incidence of streptococcal invasive infections is observed worldwide. In this study, we focused on the prevalence of genes encoding superantigens and type M proteins in the population of GAS strains from invasive versus non-invasive infections. We tested 253 GAS strains: 48 strains from patients with invasive infections (18 from wound/deep skin localization, 30 from women in labour) and 205 strains from non-invasive forms (147 from common infections of the upper respiratory, 49 from the vagina of females with genital tract infections and 9 from non-invasive wound and superficial skin infections)...
April 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28400757/streptococcus-agalactiae-causing-neonatal-infections-in-portugal-2005-2015-diversification-and-emergence-of-a-cc17-pi-2b-multidrug-resistant-sublineage
#16
Elisabete R Martins, Cristiano Pedroso-Roussado, José Melo-Cristino, Mário Ramirez
The molecular characterization of 218 GBS isolates recovered from neonatal invasive infections in Portugal in 2005-2015 revealed the existence of a small number of genetically distinct lineages that were present over a significant time-span. Serotypes III and Ia were dominant in the population, together accounting for >80% of the isolates. Clonal complex 17 included 50% of all isolates, highlighting the importance of the hypervirulent genetic lineage represented by serotype III ST17/rib/PI-1+PI-2b. Serotype Ia was represented mainly by ST23, previously reported as dominant among invasive disease in non-pregnant adults in Portugal, but also by ST24, showing an increased frequency among late-onset disease...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28387490/-an-rare-complication-of-scarlet-fever-invasive-group-a-streptococcal-infection-with-streptococcal-toxic-shock-syndrome
#17
H Warnier, Z Depuis, K Nyamugabo, B Desprechins, M-C Seghaye
Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are particulary challenging because of their rapid progression and the lack of predisposing factors in most cases. Prompt diagnosis and treatment are mandatory to reduce the mortality associated with these severe diseases. We report the case of an 8- year-old girl who developped an invasive group A streptococcal disease with osteomyelitis and streptococcal toxic shock syndrome in the course of a classical scarlet fever...
March 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28383686/cluster-of-fatal-group-a-streptococcal-emm87-infection-within-a-single-family-molecular-basis-for-invasion-and-transmission
#18
Anthony R Flores, Ruth Ann Luna, Jessica K Runge, Samuel A Shelburne, Carol J Baker
Hypervirulent disease due to group A Streptococcus (GAS) can result from strains with mutations that enhance virulence gene expression but reduce subsequent transmission. We used whole genome sequencing to investigate intra-familial spread between 4 siblings of a hypervirulent GAS strain resulting in a fatality. All invasive and pharyngeal GAS isolates had an identical mutation in a gene encoding a key regulatory protein that yielded a hyperinvasive phenotype. These data challenge the prevailing theory of reduced transmission induced by mutations that lead to hypervirulent GAS by showing that spread of hypervirulent GAS may lead to clusters of invasive disease...
April 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28376809/molecular-characterization-of-penicillin-non-susceptible-streptococcus-pneumoniae-isolated-before-and-after-pneumococcal-conjugate-vaccine-implementation-in-casablanca-morocco
#19
Idrissa Diawara, Abouddihaj Barguigua, Khalid Katfy, Kaotar Nayme, Houria Belabbes, Mohammed Timinouni, Khalid Zerouali, Naima Elmdaghri
BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide, especially among children and the elderly. The ability to effectively treat pneumococcal infection has been compromised due to the acquisition of antibiotic resistance, particularly to β-lactam drugs. This study aimed to describe the prevalence and molecular evolution of penicillin non-susceptible S. pneumoniae (PNSP) isolated from invasive diseases before and after pneumococcal conjugate vaccine implementation in Casablanca, Morocco...
April 4, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28373352/the-perr-regulated-p1b-4-type-atpase-pmta-acts-as-a-ferrous-iron-efflux-pump-in-streptococcus-pyogenes
#20
Andrew G Turner, Cheryl-Lynn Y Ong, Karrera Y Djoko, Nicholas P West, Mark R Davies, Alastair G McEwan, Mark J Walker
Streptococcus pyogenes (group A Streptococcus; GAS) is an obligate human pathogen responsible for a broad spectrum of human disease. GAS has a requirement for metal homeostasis within the human host and as such, tightly modulates metal uptake and efflux during infection. Metal acquisition systems are required to combat metal sequestration by the host, while metal efflux systems are essential to protect against metal overload poisoning. Here, we investigated the function of PmtA (PerR-regulated metal transporter A), a P1B-4 type ATPase efflux pump, in the invasive GAS M1T1 strain 5448...
April 3, 2017: Infection and Immunity
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