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https://www.readbyqxmd.com/read/29228374/quantitative-trait-loci-mapping-of-western-corn-rootworm-coleoptera-chrysomelidae-host-plant-resistance-in-two-populations-of-doubled-haploid-lines-in-maize-zea-mays-l
#1
Martin O Bohn, Juan J Marroquin, Sherry Flint-Garcia, Kenton Dashiell, David B Willmot, Bruce E Hibbard
Over the last 70 yr, more than 12,000 maize accessions have been screened for their level of resistance to western corn rootworm, Diabrotica virgifera virgifera (LeConte; Coleoptera: Chrysomelidae), larval feeding. Less than 1% of this germplasm was selected for initiating recurrent selection or other breeding programs. Selected genotypes were mostly characterized by large root systems and superior root regrowth after root damage caused by western corn rootworm larvae. However, no hybrids claiming native (i...
December 8, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29224062/relationship-between-caries-experience-and-demarcated-hypomineralised-lesions-including-mih-in-the-permanent-dentition-of-15-year-olds
#2
Jan Kühnisch, Lamiaa Kabary, Yuri Malyk, Katrin Rothmaier, Isabel Metz, Reinhard Hickel, Joachim Heinrich, David Manton, Marie Standl
OBJECTIVE: This cross-sectional study compared the caries experience in 15-year-olds with and without demarcated hypomineralised lesions (DHL) in permanent teeth. MATERIAL AND METHODS: One thousand three hundred and two 15-year-old adolescents from two ongoing birth cohorts (GINIplus15 and LISAplus15) were examined to determine non-cavitated carious lesions (NCCL) and the DMF index. Furthermore, DHL was scored on all permanent teeth/surfaces according to the molar-incisor hypomineralisation criteria of the European Academy of Paediatric Dentistry (MIH/EAPD)...
December 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29205095/lexical-access-ability-and-cognitive-predictors-of-speech-recognition-in-noise-in-adult-cochlear-implant-users
#3
Marre W Kaandorp, Cas Smits, Paul Merkus, Joost M Festen, S Theo Goverts
Not all of the variance in speech-recognition performance of cochlear implant (CI) users can be explained by biographic and auditory factors. In normal-hearing listeners, linguistic and cognitive factors determine most of speech-in-noise performance. The current study explored specifically the influence of visually measured lexical-access ability compared with other cognitive factors on speech recognition of 24 postlingually deafened CI users. Speech-recognition performance was measured with monosyllables in quiet (consonant-vowel-consonant [CVC]), sentences-in-noise (SIN), and digit-triplets in noise (DIN)...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29199519/outcomes-of-da-epoch-r-induction-plus-autologous-transplant-consolidation-for-double-hit-lymphoma
#4
Andy I Chen, Jessica T Leonard, Craig Y Okada, Nathan D Gay, Kari Chansky, Guang Fan, Jennifer B Dunlap, Philipp W Raess, Rita M Braziel, Alex Stentz, Richard T Maziarz
High-grade B cell lymphoma with MYC and BCL2 rearrangements (double hit) has a poor prognosis with standard R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). We report here a treatment algorithm of DA-EPOCH-R (dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab) followed by BEAM (carmustine, etoposide, cytarabine, melphalan) autologous transplant in 36 cases of previously untreated double hit lymphoma (DHL) from 2010 to 2015. A high risk International Prognostic Index (IPI) was present in 42% of cases...
December 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29196080/outcomes-after-allogeneic-stem-cell-transplantation-in-patients-with-double-hit-and-double-expressor-lymphoma
#5
Alex F Herrera, Scott J Rodig, Joo Y Song, Young Kim, Gabriel K Griffin, Dongyun Yang, Liana Nikolaenko, Matthew Mei, Victoria Bedell, Paola Dal Cin, Christine Pak, Edwin P Alyea, Elizabeth Budde, Robert Chen, Yi-Bin Chen, Wing C Chan, Corey S Cutler, Vincent T Ho, John Koreth, Amrita Krishnan, Joyce L Murata-Collins, Sarah Nikiforow, Joycelynne Palmer, German A Pihan, Raju Pillai, Leslie Popplewell, Steven T Rosen, Tanya Siddiqi, Aliyah R Sohani, Jasmine Zain, Larry W Kwak, Dennis D Weisenburger, David M Weinstock, Robert J Soiffer, Joseph H Antin, Stephen J Forman, Auayporn P Nademanee, Philippe Armand
Double-hit lymphomas (DHL) and double-expressor lymphomas (DEL) are associated with resistance to frontline and salvage immunochemotherapy, as well as autologous stem cell transplantation (SCT). We hypothesized that allogeneic SCT (alloSCT) could overcome the chemoresistance associated with DEL/DHL. We retrospectively studied the impact of DEL/DHL status in a multicenter cohort of patients who underwent alloSCT for relapsed/refractory (rel/ref) aggressive B-cell non-Hodgkin lymphoma (B-NHL). 78 patients transplanted at 3 centers in whom tumor tissue was available for immunohistochemistry and FISH were enrolled; 47% had DEL and 13% had DHL...
November 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29166501/primary-cutaneous-t-cell-lymphoma-experience-from-the-peruvian-national-cancer-institute
#6
Rosana Ruiz, Zaida Morante, Raul Mantilla, Luis Mas, Luis Casanova, Henry L Gomez
BACKGROUND: Primary cutaneous T-cell lymphomas constitute a heterogeneous and rare group of diseases with regional particularities in Latin America. OBJECTIVE: To determine the clinicopathological features, relative frequency and survival among patients from a Peruvian institution. METHODS: Primary cutaneous T-cell lymphomas were defined based on the absence of extracutaneous disease at diagnosis. Classification was performed following the 2008 World Health Organization Classification of Neoplasms of the Hematopoietic and Lymphoid tissues...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29115587/anticancer-effect-of-quinacrine-on-diffuse-large-b%C3%A2-cell-lymphoma-via-inhibition-of-msi2%C3%A2-numb-signaling-pathway
#7
Shujun Yang, Lixia Sheng, Kaihong Xu, Yi Wang, Huiling Zhu, Ping Zhang, Qitian Mu, Guifang Ouyang
Diffuse large B‑cell lymphoma (DLBCL) is the most common subtype of non‑Hodgkin's lymphoma. Despite improvements in the clinical outcomes of DLBCL, ~30% of patients will develop relapse/refractory disease. Therefore, novel therapeutic drugs have been investigated to improve disease outcomes. Previous studies have revealed the anticancer effects of quinacrine (QC) on tumor cells in vitro, although its role in human DLBCL is yet to be identified. The present study sought to examine the cytotoxic effect of QC on DLBCL cells...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29042970/effects-of-17-dmag-on-diffuse-large-b-cell-lymphoma-cell-apoptosis
#8
Jia-Jia Li, Jing-Jing Zhang, Xiu Wang, Zi-Min Sun
17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a water soluble, semisynthetic derivative of endotoxin that has anticancer effects. The aim of the present study was to determine whether 17-DMAG enhances the apoptosis of lymphoma cells in diffuse large B-cell lymphoma. Apoptosis was induced in SU-DHL-4 diffuse large B-cell lymphoma cells treated with 17-DMAG, as evaluated by MTT assay and flow cytometry analysis. Apoptosis-associated protein levels were assessed using western blotting, and the results indicated that B-cell lymphoma 2 (Bcl-2)-associated protein X (Bax) was upregulated, whereas heat shock protein family A member 5 (HSPA5) and Bcl-2 were downregulated...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042405/sterol-methyltransferase-a-target-for-anti-amoeba-therapy-towards-transition-state-analog-and-suicide-substrate-drug-design
#9
Medhanie E Kidane, Boden H Vanderloop, Wenxu Zhou, Crista D Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W David Nes
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth (Haubrich, B. A. et al. 2015. J. Lipid Res. 56: 331-341) and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24/28methylases (SMT) that catalyze the committed step in C28- and C29-sterol synthesis. Intriguingly, our kinetic analyses suggest 24SMT prefers plant cycloartenol while 28SMT prefers 24(28)methylene lophenol in similar fashion to the substrate preferences of land plant SMT1 and SMT2...
October 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28976590/mycobacterial-cord-factor-enhances-migration-of-neutrophil-like-hl-60-cells-by-prolonging-akt-phosphorylation
#10
Wook-Bin Lee, Ji-Jing Yan, Ji-Seon Kang, Seok Chung, Lark Kyun Kim
Trehalose 6,6'-dimycolate (TDM), or cord factor, is a crucial stimulus of immune responses during Mycobacterium tuberculosis infection. Although TDM has immuno-stimulatory properties, including adjuvant activity and the ability to induce granuloma formation, the mechanisms underlying these remain unknown. We hypothesized that TDM stimulates transendothelial migration of neutrophils, which are the first immune cells to infiltrate the tissue upon infection. In this study, it was shown that TDM enhances N-formylmethionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis and transendothelial movement by prolonging AKT phosphorylation in human neutrophils...
October 4, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28952038/double-hit-large-b-cell-lymphoma
#11
REVIEW
Yousef Khelfa, Yehuda Lebowicz, Muhammad Omer Jamil
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately 25% of NHL cases. It is a heterogeneous group of diseases. BCL2, BCL6, and MYC are the most frequent mutated genes in DLBCL. Double-hit lymphoma (DHL) is an aggressive form of DLBCL with an unmet treatment need, in which MYC rearrangement is present with either BCL2 or BCL6 rearrangement. Patients typically present with a rapidly growing mass with B symptoms. DHL has been linked to very poor outcomes when treated with RCHOP chemotherapy...
September 26, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28873492/-blood-pressure-measurement-and-treatment-targets-position-paper-of-the-dhl%C3%A2-task-force-scientific-statements-and-guidelines
#12
Bernhard K Krämer, Martin Hausberg, Bernd Sanner, Kristina Kusche-Vihrog, Joachim Weil, Burkhard Weisser, Ulrich Wenzel, Peter Trenkwalder
No abstract text is available yet for this article.
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28863235/therapeutic-potential-of-%C3%AE-lipoic-acid-derivative-sodium-zinc-histidine-dithiooctanamide-in-a-mouse-model-of-allergic-rhinitis
#13
Toshiaki Nakano, Li-Wen Hsu, Chia-Yun Lai, Yuki Takaoka, Masafumi Inomata, Seigo Kitano, Chao-Long Chen, Shigeru Goto
BACKGROUND: Oxidative stress is involved in various diseases, including allergies. Several studies have pointed to the preventive and therapeutic potential of antioxidants in allergic disorders. However, little is known about the immunomodulatory effects of antioxidants in type I hypersensitivity. In this study we aimed to explore the impact of a water-soluble antioxidant and α-lipoic acid derivative, sodium zinc histidine dithiooctanamide (DHL-HisZn), on mast-cell- and T-cell-mediated allergic and immune responses both in vitro and in vivo...
September 1, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28806980/factors-influencing-outcomes-after-medial-hamstring-lengthening-with-semitendinosus-transfer-in-patients-with-cerebral-palsy
#14
Ki Hyuk Sung, Jaebong Lee, Chin Youb Chung, Kyoung Min Lee, Byung Chae Cho, Seung Jun Moon, Jaeyoung Kim, Moon Seok Park
BACKGROUND: Although several studies have investigated the outcomes after distal hamstring lengthening (DHL), no study has undertaken an approach that included all or most of the important factors that could influence the results. This study was performed to evaluate the outcomes after DHL and analyze the factors that influence the improvement and serial change in knee motion after surgery in patients with cerebral palsy (CP), using a linear mixed model (LMM). METHODS: The study included 314 ambulatory CP patients (594 limbs) with spsastic diplegia who were followed up after undergoing DHL as part of a single-event multilevel surgery and who underwent preoperative and postoperative 3-dimensional (3D) gait analyses...
August 14, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28766546/-diffuse-large-b-cell-lymphoma-with-concomitant-c-myc-and-bcl6-gene-rearrangements-with-primary-skin-involvement-a-case-report-and-a-review-of-literature
#15
N G Gabeeva, D A Koroleva, A V Belyaeva, N G Chernova, L A Kuzmina, A B Sudarikov, T N Obukhova, A M Kovrigina, E E Zvonkov, V G Savchenko
Double-hit lymphoma (DHL) is a rare aggressive B-cell lymphoma with concomitant c-MYC, BCL2 or BCL6 gene rearrangements, which is characterized by the high frequency of extranodal lesions and by resistance to chemotherapy. The median survival does not exceed 18 months in patients with this disease. The majority of DHL is represented by с-MYC/BCL2 cases. The combination of c-MYC/BCL6 occurs rarely (5-8%). The paper describes a case of DHL with concomitant c-MYC and BCL6 gene rearrangements, which mimics diffuse large B-cell lymphoma, leg-type...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28712322/is-now-the-time-for-molecular-driven-therapy-for-diffuse-large-b-cell-lymphoma
#16
REVIEW
Alice Di Rocco, Federico De Angelis, Michela Ansuinelli, Robin Foà, Maurizio Martelli
Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder. Novel additional predictors of outcomes and new therapeutic strategies are being introduced to improve outcomes. Areas covered: This review aims to analyse the recent molecular discoveries in DLBCL, the rationale of novel molecular driven treatments and their impact on DLBCL prognosis, especially in ABC-DLBCL and High Grade B Cell Lymphoma...
September 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28711572/emerging-strategies-in-treating-double-hit-lymphomas
#17
REVIEW
Chadi Nabhan, Anthony R Mato
Double hit lymphomas (DHLs) are a new category in the World Health Organization newest classification for lymphoid malignancies. DHL encompasses various histologies of lymphomas where the MYC oncogene and either BCL2 or BCL6 oncogenes are present concomitantly. Several observational studies and retrospective series have demonstrated that patients with DHL carry a poor prognosis and respond less and for a shorter duration to standard R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin, and prednisone)...
September 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28675026/crizotinib-in-combination-with-everolimus-synergistically-inhibits-proliferation-of-alk-positive-anaplastic-large-cell-lymphoma
#18
Wendan Xu, Ji-Won Kim, Woo June Jung, Youngil Koh, Sung-Soo Yoon
Purpose: Anaplastic large cell lymphoma (ALCL) is a rare aggresive non-Hodgkin lymphoma, of which over 50% of cases have an aberrant NPM-ALK fusion protein. Both mTOR inhibitor everolimus and ALK inhibitor crizotinib have shown promising antitumor activity in ALK-positive cancer cell lines. However, their combined effect has not yet been investigated. Materials and Methods: We evaluated the anti-proliferative effects of everolimus and/or crizotinib in ALK-positive ALCL cell lines, Karpas 299 and SU-DHL-1, and lung adenocarcinoma cell line, NCI-H2228...
June 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28643399/distributed-health-literacy-among-people-living-with-type-2-diabetes-in-portugal-defining-levels-of-awareness-and-support
#19
Liliana Abreu, João Arriscado Nunes, Peter Taylor, Susana Silva
This study embraces a patient-centred and narrative-oriented notion of health literacy, exploring how social networks and personal experiences constitute distributed health literacy (DHL) by mapping out health literacy mediators of each individual and how they enable self-management skills and knowledge of health conditions. Semi-structured interviews with 26 patients with type 2 diabetes were conducted in a Primary Care Center of Porto (Portugal) from October 2014 to December 2015. Data were collected based on McGill Illness Narrative Interview (MINI)...
June 22, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28475457/outcomes-of-patients-with-double-hit-lymphoma-who-achieve-first-complete-remission
#20
MULTICENTER STUDY
Daniel J Landsburg, Marissa K Falkiewicz, Joseph Maly, Kristie A Blum, Christina Howlett, Tatyana Feldman, Anthony R Mato, Brian T Hill, Shaoying Li, L Jeffrey Medeiros, Pallawi Torka, Francisco Hernandez-Ilizaliturri, Nishitha M Reddy, Arun Singavi, Timothy S Fenske, Julio C Chavez, Jason B Kaplan, Amir Behdad, Adam M Petrich, Martin A Bast, Julie M Vose, Adam J Olszewski, Cristiana Costa, Frederick Lansigan, James N Gerson, Stefan K Barta, Oscar Calzada, Jonathon B Cohen, Jennifer K Lue, Jennifer E Amengual, Xavier Rivera, Daniel O Persky, David J Peace, Sunita Nathan, Ryan D Cassaday
Purpose Patients with double-hit lymphoma (DHL) rarely achieve long-term survival following disease relapse. Some patients with DHL undergo consolidative autologous stem-cell transplantation (autoSCT) to reduce the risk of relapse, although the benefit of this treatment strategy is unclear. Methods Patients with DHL who achieved first complete remission following completion of front-line therapy with either rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or intensive front-line therapy, and deemed fit for autoSCT, were included...
July 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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