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JOURNAL ARTICLE
Mike Ton, Maximilian Deng, Eva Meixner, Tanja Eichkorn, Anna Krämer, Katharina Seidensaal, Juliane Hörner-Rieber, Jonathan Lischalk, Klaus Herfarth, Jürgen Debus, Laila König
BACKGROUND: Solitary fibrous tumors (SFT) of the central nervous system are rare and treatment options are not well established. The aim of this study was to evaluate the clinical outcomes of radiotherapy (RT) and re-radiotherapy (re-RT) for de novo intracranial SFT and recurrent intracranial SFT. METHODS: This retrospective study analyzed efficacy and toxicity of different RT modalities in patients who received radiotherapy (RT) for intracranial SFT at Heidelberg University Hospital between 2000 and 2020 following initial surgery after de novo diagnosis ("primary group")...
March 29, 2024: Radiation Oncology
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JOURNAL ARTICLE
Felix Korell, Lukas Entenmann, Sebastian Romann, Evangelos Giannitsis, Anita Schmitt, Carsten Müller-Tidow, Norbert Frey, Peter Dreger, Michael Schmitt, Lorenz H Lehmann
BACKGROUND: Assessment of cardiovascular risk is critical for patients with cancer. Previous retrospective studies suggest potential cardiotoxicity of CAR T cell therapies. We aimed to prospectively assess cardiotoxicity and the predictive value of cardiac biomarkers and classical risk factors (age, cardiac function, diabetes, arterial hypertension, smoking) for cardiac events and all-cause mortality (ACM). METHODS: In this prospective cohort study, all patients treated with CAR T cell constructs (axi-cel, tisa-cel, brexu-cel, ide-cel, or the 3rd generation CAR HD-CAR-1) from Oct 1, 2018, to Sept 30, 2022 at the University Hospital Heidelberg were included...
March 2024: EClinicalMedicine
#23
JOURNAL ARTICLE
Pragati Tiwari, Amit Raj, Prateek Nishant
PURPOSE: To compare anterior chamber angle (ACA) parameters measured by Anterior Segment Optical Coherence Tomography (ASOCT) and biometric parameters measured by Swept-Source (SS) OCT-based biometry among patients with suspected occludable angles and open angles. METHODS: An analytical, cross-sectional study was performed on subjects attending our ophthalmology outpatient department with suspected occludable angles (van Herick grades 0, 1, and 2) in group 1, and with open angles (van Herick grades 3 and 4) in group 2...
March 27, 2024: International Ophthalmology
#24
JOURNAL ARTICLE
Gwendolyn Gramer, Saskia B Wortmann, Junmin Fang-Hoffmann, Dirk Kohlmüller, Jürgen G Okun, Holger Prokisch, Thomas Meitinger, Georg F Hoffmann
Newborn screening (NBS) for hepatorenal tyrosinemia type I (HT1) based on a determination of succinylacetone is performed in countries worldwide. Recently, biallelic pathogenic variants in GSTZ1 underlying maleylacetoacetate isomerase (MAAI) deficiency have been described as a differential diagnosis in individuals with slightly elevated succinylacetone detected by NBS. We report the experience with NBS for HT1 over 53 months in a large German NBS center and the identification and characterization of additional cases with MAAI deficiency, including one individual with a natural history over 32 years...
February 27, 2024: International Journal of Neonatal Screening
#25
JOURNAL ARTICLE
Kirstie Andrews, Toby Landeryou, Thomas Sicheritz-Pontén, Janet Yakubu Nale
Nontyphoidal salmonellosis is an important foodborne and zoonotic infection that causes significant global public health concern. Diverse serovars are multidrug-resistant and encode several virulence indicators; however, little is known on the role prophages play in driving these traits. Here, we extracted prophages from seventy-five Salmonella genomes which represent the fifteen important serovars in the United Kingdom. We analyzed the intact prophages for the presence of virulence genes and established their genomic relationships...
March 14, 2024: Cells
#26
JOURNAL ARTICLE
David E Reuss, Daniel Schrimpf, Asan Cherkezov, Abigail K Suwala, Tereza Lausová, Matija Snuderl, David Capper, Martin Sill, David T W Jones, Stefan M Pfister, Felix Sahm, Andreas von Deimling
The morphological patterns leading to the diagnosis of glioblastoma may also commonly be observed in several other distinct tumor entities, which can result in a mixed bag of tumors subsumed under this diagnosis. The 2021 WHO Classification of CNS Tumors has separated several of these entities from the diagnosis of glioblastoma, IDH-wildtype. This study determines the DNA methylation classes most likely receiving the diagnosis glioblastoma, IDH wildtype according to the definition by the WHO 2021 Classification and provides comparative copy number analyses...
January 2024: Free neuropathology
#27
B Poornachandra, Prathiba Hande, Sherina Thomas, Rohit Shetty, Ananth Bhandary
Inadvertent globe perforation following peribulbar anesthesia can lead to unpleasant experiences if not identified early and managed appropriately. We present the case of a 75-year-old female who came with decreased vision in the left eye (LE) following cataract surgery under peribulbar block. Her visual acuity in the right eye (RE) was 6/24 and LE was 6/75. Fundus examination of LE showed vitreous hemorrhage with localized subretinal hemorrhage along the inferotemporal arcade suggestive of globe perforation...
2024: Oman Journal of Ophthalmology
#28
JOURNAL ARTICLE
Pradeep Kumar Panigrahi
No abstract text is available yet for this article.
2024: Oman Journal of Ophthalmology
#29
JOURNAL ARTICLE
Marco Basset, Stefan O Schönland, Laura Obici, Janine Günther, Eloisa Riva, Tobias Dittrich, Paolo Milani, Virginia Valeria Ferretti, Ettore Pasquinucci, Andrea Foli, Christoph Kimmich, Martina Nanci, Claudia Bellofiore, Francesca Benigna, Jörg Beimler, Pietro Benvenuti, Francesca Fabris, Roberta Mussinelli, Mario Nuvolone, Catherine Klersy, Riccardo Albertini, Giampaolo Merlini, Ute Hegenbart, Giovanni Palladini, Norbert Blank
BACKGROUND: The kidney is involved in almost 100% of cases of AA amyloidosis, a rare disease caused by persistent inflammation with long overall survival but frequent progression to end-stage kidney failure . Identification of patients with advanced disease at diagnosis is difficult, given the absence of validated staging systems. METHODS: Newly diagnosed patients with AA amyloidosis from the Pavia (n=233, testing cohort) and Heidelberg (n=243, validation cohort) centers were included in the study...
March 21, 2024: Journal of the American Society of Nephrology: JASN
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JOURNAL ARTICLE
Grace Dewi, Shijinaraj Manjankattil, Claire Peichel, Timothy J Johnson, Sally Noll, Carol Cardona, Anup Kollanoor Johny
Reducing the colonization of Salmonella in turkeys is critical to mitigating the risk of its contamination at later stages of production. Given the increased susceptibility of newly hatched poults to Salmonella colonization, it is crucial to implement interventions that target potential transmission routes, including drinking water. As no individual intervention explored to date is known to eliminate Salmonella , the United States Department of Agriculture-Food Safety Inspection Service (USDA-FSIS) recommends employing multiple hurdles to achieve a more meaningful reduction and minimize the potential emergence of resistance...
2024: Frontiers in Microbiology
#31
JOURNAL ARTICLE
Stefan Fritze, Geva A Brandt, Sebastian Volkmer, Jonas Daub, Maria Krayem, Jacqueline Kukovic, Emanuel Schwarz, Urs Braun, Georg Northoff, Robert Christian Wolf, Katharina M Kubera, Andreas Meyer-Lindenberg, Dusan Hirjak
BACKGROUND: Understanding the relationship between psychopathology and major domains of human neurobehavioral functioning may identify new transdiagnostic treatment targets. However, studies examining the interrelationship between psychopathological symptoms, sensorimotor, cognitive, and global functioning in a transdiagnostic sample are lacking. We hypothesized a close relationship between sensorimotor and cognitive functioning in a transdiagnostic patient sample. METHODS: We applied network analysis and community detection methods to examine the interplay and centrality [expected influence (EI) and strength] between psychopathological symptoms, sensorimotor, cognitive, and global functioning in a transdiagnostic sample consisting of 174 schizophrenia spectrum (SSD) and 38 mood disorder (MOD) patients...
March 20, 2024: European Archives of Psychiatry and Clinical Neuroscience
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JOURNAL ARTICLE
Ioannis Halkiadakis, Thomas Ntravalias, Elpida Kollia, Klio Chatzistefanou, Stylianos A Kandarakis, Eleni Patsea
PURPOSE: To identify the rate and characteristics of cataract surgery candidates suitable for multifocal intraocular lens implantation among patients undergoing preoperative evaluation in a public hospital. MATERIALS AND METHODS: Screening was performed based on the patient's medical records, comprehensive ophthalmic examination, optical biometry (Zeiss, IOL Master 700) and optical coherence tomography (OCT) (Heidelberg, OCT Spectralis) in accordance with the relevant indications and contraindications mentioned in the pertinent literature...
March 20, 2024: International Ophthalmology
#33
JOURNAL ARTICLE
Irina Balazs, Manuel Stelzer, Julia Traub, Angela Horvath, Nicole Feldbacher, Vanessa Stadlbauer
Introduction: Sarcopenia is a frequent complication of liver cirrhosis, but it can also occur independently as a result of any underlying cause. The immune system plays an important role in the pathogenesis of both liver cirrhosis and sarcopenia. Neutrophil function, including neutrophil extracellular trap (NET) formation, is linked to chronic inflammation; however, it has not been extensively studied in patients with sarcopenia. Here, we aim to study if main neutrophil functions, such as phagocytosis, reactive oxygen species (ROS) production, and NET formation, are altered in patients with sarcopenia with or without liver cirrhosis...
2024: Frontiers in Cell and Developmental Biology
#34
JOURNAL ARTICLE
Adi Lukas Kurniawan, Julius Schretzmann, Rathi Paramastri, Alyssa Cho, Ali Sié, Melanie S Fischer, Till Bärnighausen, Beate Ditzen
BACKGROUND: Over- and undernutrition coexist in many African countries and pose a threat to metabolic health. This study assessed the associations between relationship satisfaction and Body Mass Index (BMI), waist circumference (WC), and glycated hemoglobin (HbA1c), in a rural population of older adults in Burkina Faso. It also explored potential gender differences and the mediating role of depressive symptoms. METHODS: Data from the "Centre de Recherche en Santé de Nouna (CRSN) Heidelberg Aging Study (CHAS)," a cross-sectional population-based study conducted in 2018 in Burkina Faso, were used in our study...
March 15, 2024: BMC Public Health
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JOURNAL ARTICLE
Bhim B Rai, Faran Sabeti, Joshua P van Kleef, Corinne F Carle, Emilie M F Rohan, Rohan W Essex, Richard C Barry, Ted Maddess
PURPOSE: To compare diagnostic power for different severities of age-related macular degeneration (AMD) of two-dimensional macular pigment optical densities (2D-MPOD) and spatially matched objective perimetry, with standard perimetry and best-corrected visual acuity (BCVA). METHODS: The ObjectiveField Analyser (OFA) provided objective perimetry, and a Heidelberg Spectralis optical coherence tomography (OCT) measured 2D-MPOD in AMD patients, both completed twice over 0...
March 14, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
#36
JOURNAL ARTICLE
Slaven Pikija, Monika Killer-Oberpfalzer, Johannes A R Pfaff, Christoph J Griessenauer, Michael Sonnberger, Milan Vosko, Johannes S Mutzenbach, Daniel Schwarzenhofer, Constantin Hecker
INTRODUCTION: Endovascular thrombectomy (EVT) and concomitant usage of intravenous alteplase (alteplase) in large vessel occlusion stroke may produce unwanted excess intracerebral hemorrhage (ICH). Whether this applies specifically to isolated occlusion of the M1 segment of the middle cerebral artery (MCA) is unknown. METHODS: A retrospective study from two tertiary thrombectomy centers. ICH was determined according to Heidelberg Bleeding Classification (HBC). Factors associated with the occurrence of ICH in EVT alone vs...
2024: Frontiers in Neurology
#37
JOURNAL ARTICLE
Tadas Naujokaitis, Victor A Augustin, Hyeck-Soo Son, Maximilian Köppe, Bogdana Kovalchuk, Gerd U Auffarth, Ramin Khoramnia
PURPOSE: The purpose of this study was to determine whether the Scheimpflug tomographically normal fellow eyes of keratoconus patients are also classified as normal using an ectasia screening algorithm based on anterior segment optical coherence tomography (AS-OCT). METHODS: This monocentric cross-sectional study included 22 very asymmetric ectasia patients with tomographically significant keratoconus in 1 eye and normal Scheimpflug tomography in the fellow eye...
March 13, 2024: Cornea
#38
JOURNAL ARTICLE
Michael Chen, Krishna C Joshi, Bradley Kolb, Clark W Sitton, Deep Kiritbhai Pujara, Michael G Abraham, Santiago Ortega-Gutierrez, Scott E Kasner, Shazam M Hussain, Leonid Churilov, Spiros Blackburn, Sophia Sundararajan, Yin C Hu, Nabeel Herial, Juan F Arenillas, Jenny P Tsai, Ronald F Budzik, William Hicks, Osman Kozak, Bernard Yan, Dennis Cordato, Nathan W Manning, Mark Parsons, Ricardo A Hanel, Amin Aghaebrahim, Teddy Wu, Pere Cardona Portela, Chirag D Gandhi, Fawaz Al-Mufti, Natalia Perez de la Ossa, Joanna Schaafsma, Jordi Blasco, Navdeep Sangha, Steven Warach, Timothy J Kleinig, Hannah Johns, Faris Shaker, Mohammad A Abdulrazzak, Abhishek Ray, Jeffery Sunshine, Amanda Opaskar, Kelsey R Duncan, Wei Xiong, Faisal K Al-Shaibi, Edgar A Samaniego, Thanh N Nguyen, Johanna T Fifi, Stavropoula I Tjoumakaris, Pascal Jabbour, Vitor Mendes Pereira, Maarten G Lansberg, Cathy Sila, Nicholas C Bambakidis, Stephen Davis, Lawrence Wechsler, Gregory W Albers, James C Grotta, Marc Ribo, Ameer E Hassan, Bruce Campbell, Michael D Hill, Amrou Sarraj
BACKGROUND: The incidence of intracerebral hemorrhage (ICH) and its effect on the outcomes after endovascular thrombectomy (EVT) for patients with large core infarcts have not been well-characterized. METHODS: SELECT2 trial follow-up imaging was evaluated using the Heidelberg Bleeding Classification (HBC) to define hemorrhage grade. The association of ICH with clinical outcomes and treatment effect was examined. RESULTS: Of 351 included patients, 194 (55%) and 189 (54%) demonstrated intracranial and intracerebral hemorrhage, respectively, with a higher incidence in EVT (134 (75%) and 130 (73%)) versus medical management (MM) (60 (35%) and 59 (34%), both P<0...
March 12, 2024: Journal of Neurointerventional Surgery
#39
JOURNAL ARTICLE
Sema Tamer Kaderli, Gabriele Piccoli, Celeste Limoli, Sofia Ginelli, Simone Caboni, Luigi Brotto, Emanuele Torti, Louise O'Toole, Paolo Nucci, Stela Vujosevic
PURPOSE: To investigate the frequency and type of artifacts on optical coherence tomography angiography (OCT-A) images and the relationship with clinical features in eyes with diabetic macular edema (DME). DESIGN: Retrospective, cross-sectional comparative study. SUBJECTS: 192 eyes of 140 patients with DME were included. METHODS: Medical records, optical coherence tomography (OCT) and OCT angiography (OCT-A) images (Spectralis, Heidelberg, Germany) and ultra-widefield color fundus photos (Optos California, Optos plc, UK) were evaluated...
March 4, 2024: Ophthalmology Retina
#40
JOURNAL ARTICLE
Luca Bollo, Georgina Arrambide, Alvaro Cobo-Calvo, Javier V Alvarez, Manel Alberich, Sergio Cabello, Joaquín Castilló, Ingrid Galan, Luciana S Midaglia, Breogan Rodriguez Acevedo, Ana Zabalza, Agustin Pappolla, Neus Mongay Ochoa, Mar Tintore, Jordi Rio, Manuel Comabella, Carmen Tur, Cristina Auger, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban, Deborah Pareto, Angela Vidal-Jordana
BACKGROUND AND OBJECTIVES: We aimed to assess the presence of retinal neurodegeneration independent of optic neuritis (ON) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the development of trans-synaptic anterograde degeneration in these patients after ON. METHODS: Cross-sectional, retrospective study of 34 adult patients with MOGAD and 23 healthy controls (HC). Clinical, optical coherence tomography (OCT), and MRI data were collected...
April 9, 2024: Neurology
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