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https://www.readbyqxmd.com/read/28922626/the-typhi-colonization-factor-tcf-is-encoded-by-multiple-non-typhoidal-salmonella-serovars-but-exhibits-a-varying-expression-profile-and-interchanging-contribution-to-intestinal-colonization
#1
Shalhevet Azriel, Alina Goren, Inna Shomer, Gili Aviv, Galia Rahav, Ohad Gal-Mor
Salmonella enterica serovars Typhi and Paratyphi A are human-restricted pathogens and the leading causative agents of enteric fever. The Typhi colonization factor (Tcf) is a chaperone-usher fimbria, thought to play a role in the host-specificity of typhoidal serovars. Here we show that the tcf cluster (tcfABCD tinR tioA) is present in at least 25 non-typhoidal Salmonella (NTS) serovars and demonstrate its native expression in clinically-important serovars including Schwarzengrund, 9,12:l,v:-, Choleraesuis, Bredeney, Heidelberg, Montevideo, Virchow and Infantis...
September 18, 2017: Virulence
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-s-minnesota-in-european-union-2014-2015
#2
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella has been described at low level in EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC-resistant genes. We evaluated ESC resistance and characterized genetic platforms as well as the clonal relatedness of Salmonella isolates from poultry meat products imported into Portugal. All Salmonella isolates recovered from samples of fresh meat destined to be imported into the EU in the scope of Portuguese official border control between 2014 and 2015 were studied...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28915261/simultaneous-determination-of-3-hydroxypropionic-acid-methylmalonic-acid-and-methylcitric-acid-in-dried-blood-spots-second-tier-lc-ms-ms-assay-for-newborn-screening-of-propionic-acidemia-methylmalonic-acidemias-and-combined-remethylation-disorders
#3
Péter Monostori, Glynis Klinke, Sylvia Richter, Ákos Baráth, Ralph Fingerhut, Matthias R Baumgartner, Stefan Kölker, Georg F Hoffmann, Gwendolyn Gramer, Jürgen G Okun
BACKGROUND AND AIMS: Increased propionylcarnitine levels in newborn screening are indicative for a group of potentially severe disorders including propionic acidemia (PA), methylmalonic acidemias and combined remethylation disorders (MMACBL). This alteration is relatively non-specific, resulting in the necessity of confirmation and differential diagnosis in subsequent tests. Thus, we aimed to develop a multiplex approach for concurrent determination of 3-hydroxypropionic acid, methylmalonic acid and methylcitric acid from the same dried blood spot (DBS) as in primary screening (second-tier test)...
2017: PloS One
https://www.readbyqxmd.com/read/28910140/impact-of-clinical-salmonellosis-in-veal-calves-on-the-recovery-of-salmonella-in-lymph-nodes-at-harvest
#4
Lohendy Muñoz-Vargas, Sarah K Finney, Holden Hutchinson, Margaret A Masterson, Greg Habing
The objective of this study was to determine the prevalence, serotypes, antimicrobial resistance phenotypes, and pulsed-field gel electrophoresis (PFGE) patterns of Salmonella recovered in feces and mesenteric and prefemoral lymph nodes (LNs) from cohorts of calves with and without a confirmed outbreak of salmonellosis. In a prospective cohort study, 160 calves from four farms without a reported outbreak (nonoutbreak farms) were sampled at farm and harvest. In addition, harvest samples from 80 calves of two farms with a confirmed outbreak (outbreak farms) were collected...
September 14, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28904216/anterior-segment-optical-coherence-tomography-of-previously-operated-extraocular-muscles
#5
Matthew S Pihlblad, James D Reynolds
BACKGROUND AND PURPOSE: To assess the possibility of determining the insertion distance from the limbus of previously operated extraocular rectus muscles (EOM) with the Heidelberg Spectralis anterior segment optical coherence tomography (AS-OCT). PATIENT AND METHOD: Subjects with a history of previous strabismus surgery underwent AS-OCT of the EOM before planned additional strabismus surgery. The EOM insertion distances from the limbus were measured pre-operatively on the AS-OCT and compared to the caliper distance measured during the strabismus surgery...
January 2017: American Orthoptic Journal
https://www.readbyqxmd.com/read/28902330/centrifugal-extension-of-retinal-atrophy-in-retinal-pigment-epithelium-tears-secondary-to-age-related-macular-degeneration
#6
Vittorio Capuano, Roberta Farci, Alexandra Miere, Francesca Amoroso, Francesco Bandello, Eric H Souied, Giuseppe Querques
BACKGROUND AND OBJECTIVE: To investigate the progression of retinal atrophy in patients with retinal pigment epithelium (RPE) tears secondary to neovascular age-related macular degeneration. PATIENTS AND METHODS: In this retrospective case series, patients were analyzed at two high-volume referral centers. The extension of the areas without RPE was analyzed yearly from baseline to last examination through fundus autofluorescence (FAF) imaging using Region Finder (Heidelberg Engineering, Heidelberg, Germany)...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28902095/detection-of-treatment-naive-choroidal-neovascularization-in-age-related-macular-degeneration-by-swept-source-optical-coherence-tomography-angiography
#7
Daniel Ahmed, Martin Stattin, Alexandra Graf, Julia Forster, Carl Glittenberg, Ilse Krebs, Siamak Ansari-Shahrezaei
PURPOSE: To compare the detection rate of choroidal neovascularization (CNV) in treatment-naive neovascular age-related macular degeneration by swept source optical coherence tomography angiography (SS-OCTA, Topcon's DRI Triton) working at 1,050 nm wavelength versus fluorescence angiography. METHODS: Cross-sectional analysis of 156 eyes (107 neovascular age-related macular degeneration and 49 dry AMD) in 98 patients, previously diagnosed by multimodal imaging using fluorescein (FA) and indocyanine green angiography (Heidelberg's Spectralis) in a tertiary retina center, evaluated by SS-OCTA 4...
September 4, 2017: Retina
https://www.readbyqxmd.com/read/28898231/albumin-bilirubin-uric-acid-and-cancer-risk-results-from-a-prospective-population-based-study
#8
Tilman Kühn, Disorn Sookthai, Mirja E Graf, Ruth Schübel, Heinz Freisling, Theron Johnson, Verena Katzke, Rudolf Kaaks
BACKGROUND: It has long been proposed that albumin, bilirubin and uric acid may inhibit cancer development due to their anti-oxidative properties. However, there is a lack of population-based studies on blood levels of these molecules and cancer risk. METHODS: Associations between pre-diagnostic serum albumin, bilirubin and uric acid and the risks of common cancers as well as cancer death in the EPIC-Heidelberg cohort were evaluated by multivariable Cox regression analyses...
September 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28895631/-oct-angiography-of-rpe-tears-in-exudative-amd-morpohological-analysis-of-the-choriocapillaris-and-the-rpe
#9
Matthias Gutfleisch, Kai Rothaus, Marie-Louise Farecki, Henrik Faatz, Britta Heimes-Bussmann, Frederic Gunnemann, Martin Ziegler, Ioannis Papapostolou, Albrecht Lommatzsch, Daniel Pauleikoff
Background Retinal pigment epithelium (RPE) tears are a typical complication of vascular pigment epithelium detachment in age-related macular degeneration (AMD). During proactive intense anti-VEGF therapy, stabilisation or improvement of function may occur. With the new method of OCT angiography (OCT-A), retinal vessels and flow density can be quantified. This pilot study investigates changes in the choriocapillars (CC) in areas with increasing FAF in OCT following an RPE-tear. Methods In six eyes with an RPE-tear, prospectively initially and every three months thereafter, multimodal imaging was performed, including fundus autofluorescence (FAF) (HRA2, Heidelberg Engineering, Heidelberg, Deutschland) and OCT-A (RTVue XR Avanti, SSDA-Modus, Angiovue, Optovue, Freemont, CA, USA)...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28890924/measuring-attitudes-towards-interprofessional-learning-testing-two-german-versions-of-the-tool-readiness-for-interprofessional-learning-scale-on-interprofessional-students-of-health-and-nursing-sciences-and-of-human-medicine
#10
Christiane Luderer, Matthias Donat, Ute Baum, Angelika Kirsten, Patrick Jahn, Dietrich Stoevesandt
Objective: In order to verify the methodological quality of two versions of a tool for measuring attitudes towards interprofessional learning, we adapted - in terms of translation and scale form - the Heidelberg Version [1] of Readiness for Interprofessional Learning Scale - RIPLS [2], a methodologically controversial tool that had been translated into German, and compared both the original and new versions. Method: Three items were reworded and the scale form altered (from five to four levels), leading to the Halle Version that was validated by means of a cognitive pretest (n=6)...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28886754/on-farm-biosecurity-practices-and-causes-of-preweaning-mortality-in-canadian-commercial-mink-kits
#11
Nicole Compo, David L Pearl, Brian Tapscott, Amanda Storer, Jutta Hammermueller, Marina Brash, Patricia V Turner
BACKGROUND: Mink are an important animal commodity group in Canada and excessive kit mortality represents a significant loss to production. National biosecurity standards have been developed for Canadian mink farms, but it is unclear how well these standards have been implemented as there are no studies correlating management practices of mink producers with causes of death in mink kits. To that end, we surveyed Ontario mink producers on their biosecurity and management practices and conducted almost 5660 post mortem examinations on found-dead, preweaned kits to characterize mink farm biosecurity practices and causes of death in preweaned kits...
September 8, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28885510/pylorus-resection-does-not-reduce-delayed-gastric-emptying-after-partial-pancreatoduodenectomy-a-blinded-randomized-controlled-trial-propp-study-drks00004191
#12
Thilo Hackert, Pascal Probst, Phillip Knebel, Colette Doerr-Harim, Thomas Bruckner, Ulla Klaiber, Jens Werner, Lutz Schneider, Christoph W Michalski, Oliver Strobel, Alexis Ulrich, Markus K Diener, Markus W Büchler
OBJECTIVES: The aim of this study was to investigate the effect of pylorus resection on postoperative delayed gastric emptying (DGE) after partial pancreatoduodenectomy (PD). BACKGROUND: PD is the standard treatment for tumors of the pancreatic head. Preservation of the pylorus has been widely accepted as standard procedure. DGE is a common complication causing impaired oral intake, prolonged hospital stay, and postponed further treatment. Recently, pylorus resection has been shown to reduce DGE...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28885189/addendum-measurement-of-charged-particle-yields-from-pmma-irradiated-by-a-220-mev-u-sup-12-sup-c-beam
#13
Ilaria Mattei, Giuseppe Battistoni, Francesco Collini, Erika De Lucia, Marco Durante, Salvatore Fiore, Chiara Latessa, Carlo Mancini-Terracciano, Michela Marafini, Riccardo Mirabelli, Silvia Muraro, Riccardo Paramatti, Luca Piersanti, Antoni Rucinski, Andrea Russomando, Alessio Sarti, Christoph Schuy, Adalberto Sciubba, Elena Solfaroli Camillocci, Marco Toppi, Giacomo Traini, Serena Marta Valle, Marie Vanstalle, Vincenzo Patera
In this paper we report the re-analysis of the data published in (Piersanti et al. 2014) documenting the charged secondary particles production induced by the interaction of a 220 MeV/u 12C ion beam impinging on a polymethyl methacrylate (PMMA) target, measured in 2012 at the GSI facility in Darmstadt (Germany). This re-analysis takes into account the inhomogeneous light response of the LYSO crystal in the experimental setup measured in a subsequent experiment (2014) performed in the Heidelberg Ion- Beam Therapy Center...
September 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28880368/optimization-of-monte-carlo-particle-transport-parameters-and-validation-of-a-novel-high-throughput-experimental-setup-to-measure-the-biological-effects-of-particle-beams
#14
Darshana Patel, Lawrence Bronk, Fada Guan, Christopher R Peeler, Stephan Brons, Ivana Dokic, Amir Abdollahi, Claudia Rittmüller, Oliver Jäkel, David Grosshans, Radhe Mohan, Uwe Titt
PURPOSE: Accurate modeling of the relative biological effectiveness (RBE) of particle beams requires increased systematic in vitro studies with human cell lines with care towards minimizing uncertainties in biologic assays as well as physical parameters. In this study we describe a novel high-throughput experimental setup and an optimized parameterization of the Monte Carlo (MC) simulation technique that is universally applicable for accurate determination of RBE of clinical ion beams...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28864548/cell-scientist-to-watch-ana-garcia-saez
#15
(no author information available yet)
Ana Garcia-Saez graduated with a master's degree in biochemistry from the University of Valencia, Spain, before completing a PhD in the laboratory of Jesus Salgado in 2005. Afterwards Ana joined the research group of Petra Schwille at the Dresden University of Technology, Germany. In 2010, she started her own group at BioQuant, the Center for Quantitative Analysis of Molecular and Cellular Biosystems, at Heidelberg University with funding from the Max Planck Institute for Intelligent Systems and the German Cancer Research Centre (DKFZ)...
September 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28863864/two-pools-of-vesicles-associated-with-synaptic-ribbons-are-molecularly-prepared-for-release
#16
Proleta Datta, Jared Gilliam, Wallace B Thoreson, Roger Janz, Ruth Heidelberger
Neurons that form ribbon-style synapses are specialized for continuous exocytosis. To this end, their synaptic terminals contain numerous synaptic vesicles, some of which are ribbon associated, that have difference susceptibilities for undergoing Ca(2+)-dependent exocytosis. In this study, we probed the relationship between previously defined vesicle populations and determined their fusion competency with respect to SNARE complex formation. We found that both the rapidly releasing vesicle pool and the releasable vesicle pool of the retinal bipolar cell are situated at the ribbon-style active zones, where they functionally interact...
August 29, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28862734/utility-of-bruch-membrane-opening-based-optic-nerve-head-parameters-in-myopic-subjects
#17
Marina Sastre-Ibañez, Jose M Martinez-de-la-Casa, Gema Rebolleda, Pilar Cifuentes-Canorea, Maria Nieves-Moreno, Laura Morales-Fernandez, Federico Saenz-Frances, Julian Garcia-Feijoo
PURPOSE: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. METHODS: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software...
August 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#18
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28858153/attenuation-coefficients-from-sd-oct-data-structural-information-beyond-morphology-on-rnfl-integrity-in-glaucoma
#19
Gijs Thepass, Hans G Lemij, Koenraad A Vermeer
PURPOSE: To explore the attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL) in spectral domain optical coherence tomography (OCT) images, in healthy eyes and eyes affected by glaucoma. To assess the relation between RNLF AC, disease severity, RNFL thickness, visual field sensitivity threshold, spatial location and age. PATIENTS AND METHODS: We analyzed peripapillary circle scans of a clinical OCT device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) in 102 glaucoma patients and 90 healthy controls...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28851721/advances-in-stem-cells-and-regenerative-medicine-single-cell-dynamics-new-models-and-translational-perspectives
#20
REVIEW
Alecia-Jane Twigger, Christina H Scheel
An international cohort of over 300 stem cell biologists came together in Heidelberg, Germany in May 2017 as delegates of the 'Advances in Stem Cells and Regenerative Medicine' conference run through the European Molecular Biology Organization. This Meeting Review highlights the novel insights into stem cell regulation, new technologies aiding in discovery and exciting breakthroughs in the field of regenerative medicine that emerged from the meeting.
September 1, 2017: Development
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