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https://www.readbyqxmd.com/read/29141910/munc13-proteins-control-regulated-exocytosis-in-mast-cells
#1
Elsa M Rodarte, Marco A Ramos, Alfredo J Davalos, Daniel C Moreira, David S Moreno, Eduardo I Cardenas, Alejandro I Rodarte, Youlia Petrova, Sofia Molina, Luis E Rendon, Elizabeth Sanchez, Keegan Breaux, Alejandro Tortoriello, John Manllo, Erika A Gonzalez, Michael J Tuvim, Burton F Dickey, Alan R Burns, Ruth Heidelberger, Roberto Adachi
Mast cells (MCs) are involved in host defenses against pathogen and inflammation. Stimulated MCs release substances stored in their granules via regulated exocytosis. In other cell types, Munc13 (mammalian homolog of C. elegans uncoordinated gene 13) proteins play essential roles in regulated exocytosis. Here, we found that MCs express Munc13-2 and -4, and studied their roles using global and conditional knockout (KO) mice. In a model of systemic anaphylaxis, we found no difference between WT and Munc13-2 KO mice, but global and MC-specific Munc13-4 KO mice developed less hypothermia...
November 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29141614/differences-in-the-prevalence-of-hospitalizations-and-utilization-of-emergency-outpatient-services-for-ambulatory-care-sensitive-conditions-between-asylum-seeking-children-and-children-of-the-general-population-a-cross-sectional-medical-records-study-2015
#2
Célina Lichtl, Thomas Lutz, Joachim Szecsenyi, Kayvan Bozorgmehr
BACKGROUND: Hospitalizations for ambulatory care sensitive (ACS) conditions are established indicators for the availability and quality of ambulatory care. We aimed to assess the differences between asylum-seeking children and children of the general population in a German city with respect to (i) the prevalence of ACS hospitalizations, and (ii) the utilization of emergency outpatient services for ACS conditions. METHODS: Using anonymous account data, all children admitted to the University Hospital Heidelberg in 2015 were included in our study...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29122805/impact-of-uv-irradiation-on-electrical-impedance-spectroscopy-of-benign-nevi-study-protocol-for-a-prospective-controlled-clinical-study
#3
Christine Fink, Anissa Schweizer, Lorenz Uhlmann, Holger A Haenssle
INTRODUCTION: The clinical and histological changes of nevi after ultraviolet (UV) irradiation have been studied in detail. In contrast, the impact of UV irradiation on electrical impedance spectroscopy scores of nevi has not been investigated. However, for physicians, it is essential to know the extent to which changes in electrical impedance spectroscopy scores of nevi may be attributed to seasonal effects of UV irradiation. METHODS: This is a prospective, controlled, clinical study evaluating the impact of UV irradiation on the electrical impedance spectroscopy scores of benign nevi in 50 patients undergoing phototherapy...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29120368/lactobacillus-bulgaricus-lactobacillus-rhamnosus-and-lactobacillus-paracasei-attenuate-salmonella-enteritidis-salmonella-heidelberg-and-salmonella-typhimurium-colonization-and-virulence-gene-expression-in-vitro
#4
Muhammed Shafeekh Muyyarikkandy, Mary Anne Amalaradjou
Salmonella Enteritidis (SE), Salmonella Typhimurium (ST), and Salmonella Heidelberg (SH) have been responsible for numerous outbreaks associated with the consumption of poultry meat and eggs. Salmonella colonization in chicken is characterized by initial attachment to the cecal epithelial cells (CEC) followed by dissemination to the liver, spleen, and oviduct. Since cecal colonization is critical to Salmonella transmission along the food chain continuum, reducing this intestinal association could potentially decrease poultry meat and egg contamination...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29117065/reduced-ganglion-cell-volume-on-optical-coherence-tomography-in-patients-with-geographic-atrophy
#5
Hema L Ramkumar, Brian Nguyen, Dirk-Uwe Bartsch, Luke J Saunders, Ilkay Kilic Muftuoglu, Qisheng You, William R Freeman
PURPOSE: Geographic atrophy (GA) is the sequelae of macular degeneration. Automated inner retinal analysis using optical coherence tomography is flawed because segmentation software is calibrated for normal eyes. The purpose of this study is to determine whether ganglion cell layer (GCL) volume is reduced in GA using manual analysis. METHODS: Nineteen eyes with subfoveal GA and 22 controls were selected for morphometric analyses. Heidelberg scanning laser ophthalmoscope optical coherence tomography images of the optic nerve and macula were obtained, and the Viewing Module was used to manually calibrate retinal layer segmentation...
November 7, 2017: Retina
https://www.readbyqxmd.com/read/29116910/treatment-of-femoropopliteal-lesions-with-the-angiosculpt-scoring-balloon-results-from-the-heidelberg-panther-registry
#6
Ira Lugenbiel, Michaela Grebner, Qianxing Zhou, Anna Strothmeyer, Britta Vogel, Rita Cebola, Oliver Müller, Bernadett Brado, Marc Mittnacht, Benedikt Kohler, Hugo Katus, Erwin Blessing
BACKGROUND: Treatment of calcified femoropopliteal lesions remains challenging, even in the era of drug-eluting balloon angioplasty. Lesion recoil and dissections after standard balloon angioplasty in calcific lesions often require subsequent stent implantation. Additionally, poor patency rates in calcified lesions despite the use of drug-eluting balloons may be due to the limited penetration depth of the antiproliferative drug in the presence of vascular calcium deposits. Therefore, preparation of calcified lesions with the AngioSculpt™ scoring balloon might be a valuable option either as a stand-alone treatment, followed by drug-eluting balloon angioplasty or prior to subsequent stent deployment...
November 8, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29111901/-parenting-stress-in-mothers-of-children-with-down-syndrome-in-preschool-age
#7
Klaus Sarimski
Parenting Stress in Mothers of Children with Down Syndrome in Preschool Age Research suggests that parenting stress is elevated in parents of children with intellectual disabilities. However, data are inconsistent if this holds true for parents of children with Down syndrome. As part of the Heidelberg Down syndrome study, 52 mothers of children with Down syndrome (mean age: 5 years) completed the German adaptation of the Parenting Stress Index. These results show significantly elevated stress scores in scales measuring demanding and less acceptable behavior of the children (child characteristics)...
November 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29109895/are-all-retinal-nerve-fiber-layer-defects-on-optic-coherence-tomography-glaucomatous
#8
Sirel Gür Güngör, Akman Ahmet
Objectives: In this study, we investigated the patients who were referred to our clinic with a prediagnosis of glaucoma based on retinal nerve fiber layer (RNFL) defects on optic coherence tomography (OCT) but were determined to have nonglaucomatous RNLF defects upon detailed examination. Materials and Methods: The ophthalmic examination notes, OCT images, Heidelberg retinal tomography (HRT) II and fundus photographs of 357 patients were retrospectively evaluated...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29108727/reproducibility-of-serum-oxysterols-and-lanosterol-among-postmenopausal-women-results-from-epic-heidelberg
#9
Da-Lin Lu, Disorn Sookthai, Charlotte Le Cornet, Verena A Katzke, Theron S Johnson, Rudolf Kaaks, Renée T Fortner
BACKGROUND: Circulating oxysterols have been proposed as biological markers of disease risk. However, within-person reproducibility of circulating oxysterols over time is not well established. METHODS: We evaluated the one-year reproducibility of 11 oxysterols and lanosterol among 30 postmenopausal women with repeat blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) - Heidelberg, Germany cohort. Liquid chromatography-mass spectrometry (LC/MS) was performed to quantify serum concentrations of 22R-hydroxycholesterol, 2β-hydroxycholesterol, 24S-hydroxycholesterol, 27-hydroxycholesterol, 22S-hydroxycholeterol, 24,2β-epoxycholesterol, 5α,6β-dihydroxycholestanol, 7α-hydroxycholesterol, 5β,6β-epoxycholesterol, 5α,6α-epoxycholesterol, 24-dihydrolanosterol, and lanosterol...
November 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29105362/monitoring-foveal-sparing-in-geographic-atrophy-with-fluorescence-lifetime-imaging-ophthalmoscopy-a-novel-approach
#10
Lydia Sauer, Matthias Klemm, Sven Peters, Dietrich Schweitzer, Johanna Schmidt, Lukas Kreilkamp, Lisa Ramm, Daniel Meller, Martin Hammer
PURPOSE: To investigate fundus autofluorescence (FAF) lifetimes in geographic atrophy (GA) with a focus on macular pigment (MP) and foveal sparing. METHODS: The study included 35 eyes from 28 patients (mean age 79.2 ± 8.0 years) with GA. A 30° retinal field, centred at the macula, was investigated using fluorescence lifetime imaging ophthalmoscopy (FLIO). The FLIO technology is based on a Heidelberg Engineering Spectralis system. Decays of FAF were detected in a short (498-560 nm, SSC) and long (560-720 nm, LSC) spectral channel...
November 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29102929/three-dimensional-laser-scanning-confocal-analysis-of-conjunctival-microcysts-in-glaucomatous-patients-before-and-after-trabeculectomy
#11
Silvio DI Staso, Luca Agnifili, Angela DI Gregorio, Hilary Climastone, Emilio Galassi, Vincenzo Fasanella, Marco Ciancaglini
BACKGROUND/AIM: In glaucoma, conjunctival epithelial microcysts (CEM) have been extensively investigated by means of laser scanning confocal microscopy. In the present case series, we examined eight glaucomatous patients undergoing trabeculectomy to obtain a 3-dimensional (3-D) characterization of CEM. MATERIALS AND METHODS: Image acquisition was performed in z-scan automatic volume mode by Heidelberg Retina Tomograph III/Rostock Cornea Module and a series of 40 images of 300×300 μm (384×384 pixels) to a maximum depth of 40 μm were acquired throughout the upper bulbar conjunctiva before (at the site planned for surgery) and eight weeks after trabeculectomy...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29095359/minimal-optical-coherence-tomography-b-scan-density-for-reliable-detection-of-intraretinal-and-subretinal-fluid-in-macular-diseases
#12
Petra P Fang, Niklas Domdei, Philipp Herrmann, Steffen Schmitz-Valckenberg, Frank G Holz, Wolf M Harmening, Tim U Krohne
PURPOSE: To determine the minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid. METHODS: Spectral domain optical coherence tomography raster scanning (Spectralis; Heidelberg Engineering, Heidelberg, Germany) using a scan field of 20° × 20° of 97 B-scans with an interscan distance (ISD) of 60 μm was performed in 150 eyes of 150 consecutive patients at monitoring visits for intravitreal anti-vascular endothelial growth factor therapy...
October 30, 2017: Retina
https://www.readbyqxmd.com/read/29095354/characteristics-of-pigmented-lesions-in-type-2-idiopathic-macular-telangiectasia
#13
Irene Leung, Ferenc B Sallo, Roberto Bonelli, Traci E Clemons, Daniel Pauleikhoff, Emily Y Chew, Alan C Bird, Tunde Peto
PURPOSE: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). METHODS: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer...
October 31, 2017: Retina
https://www.readbyqxmd.com/read/29089942/the-possible-influence-of-non-synonymous-point-mutations-within-the-fima-adhesin-of-non-typhoidal-salmonella-nts-isolates-in-the-process-of-host-adaptation
#14
Sahar Alshalchi, Shivdeep S Hayer, Ran An, Jeannette Munoz-Aguayo, Christian Flores-Figueroa, Ryan Nguyen, Dale Lauer, Karen Olsen, Julio Alvarez, David Boxrud, Carol Cardona, Sinisa Vidovic
Non-typhoidal Salmonella (NTS) remains a global pathogen that affects a wide range of animal species. We analyzed a large number of NTS isolates of different host origins, including Salmonella Heidelberg (n = 80, avian), S. Dublin (50, bovine), S. Typhimurium var 5- (n = 40, porcine), S. 4,5,12,:i:- (n = 40, porcine), S. Cerro (n = 16, bovine), and S. Montevideo (n = 14, bovine), using virulence profiling of the bcfC, mgtC, ssaC, invE, pefA, stn, sopB, and siiE virulence-associated genes, a biofilm production assay, pulsed field gel electrophoresis, and the full-length sequencing of the fimA (adhesin) and iroN (receptor) genes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29075124/chronic-digitalis-therapy-in-patients-before-heart-transplantation-is-an-independent-risk-factor-for-increased-posttransplant-mortality
#15
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Ann-Kathrin Rahm, Fabrice F Darche, Dierk Thomas, Tom Bruckner, Philipp Ehlermann, Hugo A Katus, Andreas O Doesch
OBJECTIVES: Digitalis therapy (digoxin or digitoxin) in patients with heart failure is subject to an ongoing debate. Recent data suggest an increased mortality in patients receiving digitalis. This study investigated the effects of chronic digitalis therapy prior to heart transplantation (HTX) on posttransplant outcomes. PATIENTS AND METHODS: This was a retrospective, observational, single-center study. It comprised 530 adult patients who were heart-transplanted at Heidelberg University Hospital between 1989 and 2012...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29062773/optical-coherence-tomography-with-or-without-enhanced-depth-imaging-for-peripapillary-retinal-nerve-fiber-layer-and-choroidal-thickness
#16
Meng-Ai Wu, Wei-Xin Xu, Zhe Lyu, Li-Jun Shen
AIM: To assess peripapillary retinal nerve fiber layer (RNFL) and choroidal thickness obtained with enhanced depth imaging (EDI) mode compared with those obtained without EDI mode using Heidelberg Spectralis optical coherence tomography (OCT). METHODS: Fifty eyes of 25 normal healthy subjects and 32 eyes of 20 patients with different eye diseases were included in the study. All subjects underwent 3.4 mm diameter peripapillary circular OCT scan centered on the optic disc using both the conventional and the EDI OCT protocols...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29058685/study-for-online-range-monitoring-with-the-interaction-vertex-imaging-method
#17
Christian Finck, Yusuf Karakaya, Valérian Reithinger, Regina Rescigno, Jérôme Baudot, Julie Constanzo, Didier Juliani, Jochen Krimmer, Ilaria Rinaldi, Marc Rousseau, Etienne Testa, Marie Vanstalle, Cedric Ray
Ion beam therapy enables a highly accurate dose conformation delivery to the tumor due to the finite range of charged ions in matter (i.e., Bragg Peak (BP)). Consequently, the dose profile is very sensitive to patients anatomical changes as well as minor mispositioning, and so it requires improved dose control techniques. Proton Interaction Vertex Imaging (IVI) could offer an online range control in carbon ion therapy. In this paper, a statistical method was used to study the sensitivity of the IVI technique on experimental data obtained from the Heidelberg Ion-Beam Therapy Center...
October 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29058479/simultaneous-detection-of-multiple-salmonella-serovars-from-milk-and-chicken-meat-by-real-time-pcr-using-unique-genomic-target-regions
#18
Sayma Afroj, Khaled Aldahami, Gopal Reddy, Jean Guard, Abiodun Adesiyun, Temesgen Samuel, Woubit Abdela
A novel genomic and plasmid target-based PCR platform was developed for the detection of Salmonella serovars Heidelberg, Dublin, Hadar, Kentucky, and Enteritidis. Unique genome loci were obtained through extensive genome mining of protein databases and comparative genomic analysis of these serovars. Assays targeting Salmonella serovars Hadar, Heidelberg, Kentucky, and Dublin had 100% specificity and sensitivity, whereas those for Salmonella Enteritidis had 97% specificity and 88% sensitivity. The limits of detection for Salmonella serovars Heidelberg, Kentucky, Hadar, Enteritidis, and Dublin were 12, 9, 40, 13, and 5,280 CFU, respectively...
October 23, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29057371/dysflective-cones-visual-function-and-cone-reflectivity-in-long-term-follow-up-of-acute-bilateral-foveolitis
#19
Joanna H Tu, Katharina G Foote, Brandon J Lujan, Kavitha Ratnam, Jia Qin, Michael B Gorin, Emmett T Cunningham, William S Tuten, Jacque L Duncan, Austin Roorda
PURPOSE: Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear. We used fundus-referenced testing to evaluate visual function in regions of apparent cone loss identified using confocal AOSLO images. METHODS: A patient diagnosed with acute bilateral foveolitis had spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT system [Heidelberg Engineering, Vista, CA, USA]) images indicating focal loss of the inner segment-outer segment junction band with an intact, but hyper-reflective, external limiting membrane...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29053866/impact-of-litter-salmonella-status-during-feed-withdrawal-on-salmonella-recovery-from-the-broiler-crop-and-ceca
#20
R J Buhr, D V Bourassa, A Hinton, B D Fairchild, C W Ritz
Research was conducted to evaluate the impact of litter Salmonella status during feed withdrawal on Salmonella recovery from the crop and ceca following feed withdrawal. In 4 experiments, pens of broilers in separate rooms were challenged with marker strains of either Salmonella Montevideo or Salmonella Heidelberg. Three d post challenge, a 12-hour feed withdrawal was initiated, and one pen of broilers was switched between rooms for each Salmonella serotype. In experiments 3 and 4, non-challenged broilers also were added to the Salmonella challenge pens...
October 5, 2017: Poultry Science
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