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https://www.readbyqxmd.com/read/28542372/revision-of-encapsulated-blebs-after-trabeculectomy-long-term-comparison-of-standard-bleb-needling-and-modified-needling-procedure-combined-with-transconjunctival-scleral-flap-sutures
#1
P Laspas, P D Culmann, F H Grus, V Prokosch-Willing, A Poplawksi, N Pfeiffer, E M Hoffmann
PURPOSE: To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. METHODS: Forty-six patients with failing blebs after trabeculectomy with mitomycin C were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28541963/correlation-of-structural-and-functional-outcome-measures-in-a-phase-one-trial-of-ciliary-neurotrophic-factor-in-type-2-idiopathic-macular-telangiectasia
#2
Ferenc B Sallo, Irene Leung, Traci E Clemons, Tunde Peto, Emily Y Chew, Daniel Pauleikhoff, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of the break in the ellipsoid zone seen in "en face" optical coherence tomographic (OCT) images and microperimetric focal retinal sensitivity loss have been proposed as potential measures of progression in macular telangiectasia. The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia...
May 23, 2017: Retina
https://www.readbyqxmd.com/read/28536832/proteomic-profiling-reveals-crucial-retinal-protein-alterations-in-the-early-phase-of-an-experimental-glaucoma-model
#3
Fabian Anders, Julia Teister, Sebstian Funke, Norbert Pfeiffer, Franz Grus, Thanos Solon, Verena Prokosch
PURPOSE: Clinical glaucoma is difficult to assess in terms of molecular pathophysiology, prompting studies in experimental models of glaucoma. The purpose of this study was to investigate quantitative changes in retinal protein expression at the onset of experimental glaucoma in rats. Analyzing the proteome provides a suitable tool to decipher the pathophysiological processes in glaucomatous degeneration. METHODS: Thermic cauterization of episcleral veins was utilized to elevate the intraocular pressure in Sprague Dawley rats...
May 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28533247/first-detection-of-a-fosfomycin-resistance-gene-fosa7-in-salmonella-enterica-serovar-heidelberg-isolated-from-broiler-chickens
#4
Muhammad A Rehman, Xianhua Yin, Marissa G Persaud-Lachhman, Moussa S Diarra
We previously described Salmonella Heidelberg harbouring a chromosomal gene cluster similar to the glutathione S-transferase gene, a putative fosA conferring resistance to fosfomycin. Here we show that this new gene named fosA7 confers resistance to fosfomycin. Introduction of fosA7 into fosfomycin susceptible Salmonella Enteritidis, resulted in a substantial increase in the fosfomycin MIC. This finding increases awareness of antibiotic resistance in Salmonella Heidelberg from broiler related to the food safety and public health...
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28527362/mathematical-abilities-in-elementary-school-do-they-relate-to-number-space-associations
#5
Carrie Georges, Danielle Hoffmann, Christine Schiltz
Considering the importance of mathematics in Western societies, it is crucial to understand the cognitive processes involved in the acquisition of more complex mathematical skills. The current study, therefore, investigated how the quality of number-space mappings on the mental number line, as indexed by the parity SNARC (spatial-numerical association of response codes) effect, relates to mathematical performances in third- and fourth-grade elementary school children. Mathematical competencies were determined using the "Heidelberger Rechentest," a standardized German math test assessing both arithmetical and visuospatial math components...
May 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28524870/autotrophic-and-heterotrophic-acquisition-of-carbon-and-nitrogen-by-a-mixotrophic-chrysophyte-established-through-stable-isotope-analysis
#6
Ramon Terrado, Alexis L Pasulka, Alle A-Y Lie, Victoria J Orphan, Karla B Heidelberg, David A Caron
Collectively, phagotrophic algae (mixotrophs) form a functional continuum of nutritional modes between autotrophy and heterotrophy, but the specific physiological benefits of mixotrophic nutrition differ among taxa. Ochromonas spp. are ubiquitous chrysophytes that exhibit high nutritional flexibility, although most species generally fall towards the heterotrophic end of the mixotrophy spectrum. We assessed the sources of carbon and nitrogen in Ochromonas sp. strain BG-1 growing mixotrophically via short-term stable isotope probing...
May 19, 2017: ISME Journal
https://www.readbyqxmd.com/read/28510597/ubiquitylation-of-the-acetyltransferase-mof-in-drosophila-melanogaster
#7
Sarah Schunter, Raffaella Villa, Victoria Flynn, Jan B Heidelberger, Anne-Kathrin Classen, Petra Beli, Peter B Becker
The nuclear acetyltransferase MOF (KAT8 in mammals) is a subunit of at least two multi-component complexes involved in transcription regulation. In the context of complexes of the 'Non-Specific-Lethal' (NSL) type it controls transcription initiation of many nuclear housekeeping genes and of mitochondrial genes. While this function is conserved in metazoans, MOF has an additional, specific function in Drosophila in the context of dosage compensation. As a subunit of the male-specific-lethal dosage compensation complex (MSL-DCC) it contributes to the doubling of transcription output from the single male X chromosome by acetylating histone H4...
2017: PloS One
https://www.readbyqxmd.com/read/28503434/comparison-of-isolated-check-visual-evoked-potential-and-standard-automated-perimetry-in-early-glaucoma-and-high-risk-ocular-hypertension
#8
Xiang-Wu Chen, Ying-Xi Zhao
AIM: To compare the diagnostic performance of isolated-check visual evoked potential (icVEP) and standard automated perimetry (SAP), for evaluating the application values of icVEP in the detection of early glaucoma. METHODS: Totally 144 subjects (288 eyes) were enrolled in this study. icVEP testing was performed with the Neucodia visual electrophysiological diagnostic system. A 15% positive-contrast (bright) condition pattern was used in this device to differentiate between glaucoma patients and healthy control subjects...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28499747/preoperative-posturing-of-patients-with-macula-on-retinal-detachment-reduces-progression-toward-the-fovea
#9
Jan H de Jong, Juan P Vigueras-Guillén, Tiarah C Simon, Reinier Timman, Tunde Peto, Koenraad A Vermeer, Jan C van Meurs
PURPOSE: Traditionally, preoperative posturing consisting of bed rest and positioning is prescribed to patients with macula-on retinal detachment (RD) to prevent RD progression and detachment of the fovea. Execution of such advice can be cumbersome and expensive. This study aimed to investigate if preoperative posturing affects the progression of RD. DESIGN: Prospective cohort study. PARTICIPANTS: Ninety-eight patients with macula-on RD were included...
May 9, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28490427/effect-of-acute-intraocular-pressure-elevation-on-the-minimum-rim-width-in-normal-ocular-hypertensive-and-glaucoma-eyes
#10
Sourabh Sharma, Tin A Tun, Mani Baskaran, Eray Atalay, Sri Gowtham Thakku, Zhang Liang, Dan Milea, Nicholas G Strouthidis, Tin Aung, Michael Ja Girard
BACKGROUND: To estimate and compare changes in the Bruch's membrane opening-minimum rim width (BMO-MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP). METHODS: The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0...
May 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28489918/oct-angiography-a-qualitative-and-quantitative-comparison-of-4-oct-a-devices
#11
Marion R Munk, Helena Giannakaki-Zimmermann, Lieselotte Berger, Wolfgang Huf, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To compare the quality of four OCT-angiography(OCT-A) modules. METHOD: The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts...
2017: PloS One
https://www.readbyqxmd.com/read/28488474/prevalence-of-salmonella-spp-in-environmental-samples-from-table-egg-barns-in-alberta
#12
Joan A St Amand, Rashed Cassis, Robin K King, Colleen B Annett Christianson
Some Salmonella spp. are zoonotic, a frequent cause of food borne illness in Canada, and known to infect humans through contaminated poultry and poultry products. Certain serotypes of Salmonella spp. have been demonstrated to be vertically transmitted from hen to egg. The incidence of Salmonella spp. isolation in the flock has been correlated to its isolation from the environment. Twenty-one producers were enrolled in this study to examine the occurrence of Salmonella spp. in 48 table egg layer flocks housed in 35 barns in Alberta...
May 10, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28488340/abstracts-for-the-31st-european-immunogenetics-and-histocompatibility-conference-efi-25th-annual-meeting-of-the-german-society-for-immunogenetics-dgi-mannheim-heidelberg-germany-30-may-2-june-2017
#13
https://www.readbyqxmd.com/read/28486275/evaluation-of-optic-nerve-head-and-peripapillary-choroidal-vasculature-using-swept-source-optical-coherence-tomography-angiography
#14
Kyeong Ik Na, Won June Lee, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: The authors visualized arterioles from the peripapillary choroid to the optic nerve head in vivo, using swept-source optical coherence tomography angiography. METHODS AND RESULTS: In this case series, we present 3 eyes with visible centripetal branches from the peripapillary choroid. The 3 eyes were diagnosed as glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma. In the en face projection images of the choroidal layer, obtained by swept-source optical coherence tomography angiography, the vessels from the peripapillary choroid to the optic nerve head were observed in all 3 eyes; one of them was further evaluated by indocyanine green angiography using the Heidelberg retina angiograph...
May 8, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28482910/pregnancy-rates-of-day-4-and-day-5-embryos-after-culture-in-an-integrated-time-lapse-incubator
#15
Verena Holschbach, Julia Weigert, Jens Erik Dietrich, Sabine Roesner, Markus Montag, Thomas Strowitzki, Bettina Toth
BACKGROUND: The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging. METHODS: Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles performed between January 2011 and April 2016 at a tertiary referral university hospital, a total of n = 599 IVF/ICSI cycles with prolonged embryo culture in an integrated time-lapse system (EmbryoScope(©) (Vitrolife)) until day 4 or 5 were retrospectively analyzed with regard to embryo morphology and pregnancy rates...
May 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28478890/bericht-aus-der-praxis-practice-report-tutor-training-for-a-peer-assisted-interprofessional-communication-seminar-a-work-in-progress
#16
Jan Hundertmark, Angelika Homberg, Simone Alvarez, Heike Lauber, Sarah Berger, Christiane Büscher, Jobst-Hendrik Schultz, Cornelia Mahler
A novel peer-led communication seminar for medical students and for students of the Interprofessional Health Care B.Sc. degree programme at the Medical Faculty of Heidelberg is currently being developed to address the increasing need for interprofessional collaborative competencies in health care professionals. The core elements of this course include role plays in interprofessional communication situations, patient-centred professional practice, and reflections on underlying attitudes. Each seminar will be conducted by a team of two senior students from both undergraduate programmes, practising their new roles as interprofessional tutors and, at the same time, serving as competent role models for interprofessional collaboration...
May 3, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28463290/digital-holography-and-3d-imaging-introduction-to-the-joint-feature-issue-in-applied-optics-and-journal-of-the-optical-society-of-america-b
#17
Partha P Banerjee, Wolfgang Osten, Pascal Picart, Liangcai Cao, George Nehmetallah
The OSA Topical Meeting on Digital Holography and 3D Imaging (DH) was held 25-28 July 2016 in Heidelberg, Germany, as part of the Imaging Congress. Feature issues based on the DH meeting series have been released by Applied Optics (AO) since 2007. This year, AO and the Journal of the Optical Society of America B (JOSA B) jointly decided to have one such feature issue in each journal. This feature issue includes 31 papers in AO and 11 in JOSA B, and covers a large range of topics, reflecting the rapidly expanding techniques and applications of digital holography and 3D imaging...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28461015/diagnostic-accuracy-of-spectralis-sd-oct-automated-macular-layers-segmentation-to%C3%A2-discriminate-normal-from-early-glaucomatous-eyes
#18
Marta Pazos, Agnieszka Anna Dyrda, Marc Biarnés, Alicia Gómez, Carlos Martín, Clara Mora, Gianluca Fatti, Alfonso Antón
PURPOSE: To evaluate the accuracy of the macular retinal layer segmentation software of the Spectralis spectral-domain (SD) optical coherence tomography (OCT) device (Heidelberg Engineering, Inc., Heidelberg, Germany) to discriminate between healthy and early glaucoma (EG) eyes. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Forty EG eyes and 40 healthy controls were included. METHODS: All participants were examined using the standard posterior pole and the peripapillary retinal nerve fiber layer (pRNFL) protocols of the Spectralis OCT device...
April 28, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28460039/prognostic-value-of-elevated-high-sensitivity-cardiac-troponin-t-in-patients-admitted-to-an-emergency-department-with-atrial-fibrillation
#19
Kiril M Stoyanov, Evangelos Giannitsis, Moritz Biener, Matthias Mueller-Hennessen, Katharina Arens, Hugo A Katus, Mehrshad Vafaie
Aims: Elevated levels of high-sensitivity cardiac troponin T (hsTnT) indicate underlying heart disease and are known to predict adverse outcomes in various patient populations. Their role in atrial fibrillation (AF) is still under debate. Methods and results: This retrospective study included 2898 consecutive patients presenting with AF to the emergency department of the Department of Cardiology, Heidelberg University Hospital. Multivariable Cox regression was used to assess associations between hsTnT and mortality...
April 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28458517/a-comparative-study-on-endovascular-treatment-of-sub-acute-critical-limb-ischemia-mechanical-thrombectomy-vs-thrombolysis
#20
Mariya Kronlage, Ilka Printz, Britta Vogel, Erwin Blessing, Oliver J Müller, Hugo A Katus, Christian Erbel
OBJECTIVE: The aim of this study was to compare different interventional methods for treatment of (sub)acute limb ischemia upon thrombotic occlusions of the lower extremity in terms of their safety and efficacy in a tertiary hospital setting. DESIGN: This is a retrospective, single-center study of non-randomized data. METHODS: A total of 202 patients, including 26 critically ill patients, underwent rotational thrombectomy (Rotarex(®)), local thrombolysis (recombinant tissue plasminogen activator), or combination of both at the University Hospital Heidelberg (2006-2015)...
2017: Drug Design, Development and Therapy
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