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https://www.readbyqxmd.com/read/29780921/is-it-melanoma-associated-retinopathy-or-drug-toxicity-bilateral-cystoid-macular-edema-posing-a-diagnostic-and-therapeutic-dilemma
#1
Sachi R Patel, Stavros N Moysidis, Nicole Koulisis, Philip P Storey, Amir H Kashani, Narsing A Rao, Damien C Rodger
Purpose: To report the clinical presentation, multimodal imaging, and management of a patient with metastatic melanoma who presented with cystoid macular edema (CME). Observations: We report a case of a 71-year-old Caucasian male with metastatic melanoma who presented with bilateral cystoid macular edema after being on treatment with a programmed T cell death ligand 1 inhibitor, MPDL3280, for 1 year. Multimodal imaging techniques, including color fundus photographs, autofluorescence, spectral domain optical coherence tomography (OCT), fluorescein angiography (Spectralis, Heidelberg, Germany), and spectral-domain OCT angiography (Zeiss; California, USA) were performed to evaluate the etiology of his CME and to monitor his response to treatment...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29778063/comparison-of-three-dimensional-multi-segmental-foot-models-used-in-clinical-gait-laboratories
#2
Kristen Nicholson, Chris Church, Colton Takata, Tim Niiler, Brian Po-Jung Chen, Nancy Lennon, Julie P Sees, John Henley, Freeman Miller
BACKGROUND: Many skin-mounted three-dimensional multi-segmented foot models are currently in use for gait analysis. Evidence regarding the repeatability of models, including between trial and between assessors, is mixed, and there are no between model comparisons of kinematic results. RESEARCH QUESTION: This study explores differences in kinematics and repeatability between five three-dimensional multi-segmented foot models. The five models include duPont, Heidelberg, Oxford Child, Leardini, and Utah...
May 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29777305/the-distribution-of-retinal-nerve-fiber-layer-thickness-and-associations-with-age-refraction-and-axial-length-the-gutenberg-health-study
#3
Esther M Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K Schuster, Manfred E Beutel, Norbert Pfeiffer, Julia Lamparter
PURPOSE: To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting. METHODS: In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany)...
May 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29774407/beta-blockers-and-chronic-heart-failure-patients-prognostic-impact-of-a-dose-targeted-beta-blocker-therapy-vs-heart-rate-targeted-strategy
#4
Anna Corletto, Hanna Fröhlich, Tobias Täger, Matthias Hochadel, Ralf Zahn, Caroline Kilkowski, Ralph Winkler, Jochen Senges, Hugo A Katus, Lutz Frankenstein
BACKGROUND: Beta blockers improve survival in patients with chronic systolic heart failure (CHF). Whether physicians should aim for target dose, target heart rate (HR), or both is still under debate. METHODS AND RESULTS: We identified 1,669 patients with systolic CHF due to ischemic heart disease or idiopathic dilated cardiomyopathy from the University Hospital Heidelberg and the Clinic of Ludwigshafen, Germany. All patients were treated with an angiotensin converting enzyme inhibitor or angiotensin receptor blocker and had a history of CHF known for at least 6 months...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29773695/automated-computer-guided-pasi-measurements-by-digital-image-analysis-versus-conventional-physicians-pasi-calculations-study-protocol-for-a-comparative-single-centre-observational-study
#5
Christine Fink, Lorenz Uhlmann, Christina Klose, Holger A Haenssle
INTRODUCTION: Reliable and accurate assessment of severity in psoriasis is very important in order to meet indication criteria for initiation of systemic treatment or to evaluate treatment efficacy. The most acknowledged tool for measuring the extent of psoriatic skin changes is the Psoriasis Area and Severity Index (PASI). However, the calculation of PASI can be tedious and subjective and high intraobserver and interobserver variability is an important concern. Therefore, there is a great need for a standardised and objective method that guarantees a reproducible PASI calculation...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29772051/optical-coherence-tomography-angiography-of-pigmented-paravenous-retinochoroidal-atrophy
#6
Maria Vittoria Cicinelli, Chiara Giuffrè, Alessandro Rabiolo, Maurizio Battaglia Parodi, Francesco Bandello
A 58-year-old man with bilateral pigmented paravenous retinochoroidal atrophy (PPRCA) associated with macular coloboma in the right eye underwent color fundus photography and fundus autofluorescence with the California ultra-widefield retinal imaging system (Optos, Dunfermline, UK), spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany), and en face OCT angiography (OCTA) (AngioPlex, Cirrus HD-OCT 5000; Carl Zeiss Meditec, Dublin, CA)...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29750944/ellipsoid-zone-change-according-to-glaucoma-stage-advancement
#7
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: Retinal photoreceptor ellipsoid zone (EZ) intensity comparison between normal eyes and those with different stages of glaucoma. DESIGN: Retrospective cross-sectional study METHODS: The study included 37 normal, 38 pre-perimetric, 39 mild-to-moderate (visual field [VF] mean deviation [MD]: -7.7±2.0 dB), and 36 severe glaucoma eyes (VF MD: -17.8±3.2 dB). The subjects underwent high-resolution horizontal and vertical-line scans through the fovea by spectral-domain optical coherence tomography [SD-OCT] (Spectralis HRA+OCT; Heidelberg)...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29740698/meeting-report-31st-international-mammalian-genome-conference-mammalian-genetics-and-genomics-from-molecular-mechanisms-to-translational-applications
#8
REVIEW
Gabriela Sánchez-Andrade, Jacob Moskowitz, Selene Howe, Teresa M Gunn
High on the Heidelberg hills, inside the Advanced Training Centre of the European Molecular Biology Laboratory (EMBL) campus with its unique double-helix staircase, scientists gathered for the EMBL conference "Mammalian Genetics and Genomics: From Molecular Mechanisms to Translational Applications," organized in cooperation with the International Mammalian Genome Society (IMGS) and the Mouse Molecular Genetics (MMG) group. The conference attracted 205 participants from 30 countries, representing 6 of the 7 continents-all except Antarctica...
May 8, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29734400/optical-coherence-tomography-automated-layer-segmentation-of-macula-after-retinal-detachment-repair
#9
Kyu Jin Han, Young Hoon Lee
PURPOSE: To investigate the thickness of retinal layers and association with final visual acuity using spectral-domain optical coherence tomography (SD-OCT) in macular area of macula-off rhegmatogenous retinal detachment (RRD) patients after a successful macular re-attachment. METHODS: In retrospective study, a total 24 eyes with macula-off RRD were enrolled. All patients underwent vitrectomy to repair RRD. Outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor layer (PR), retinal pigment epithelium (RPE) thicknesses were measured by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) SD-OCT with automated segmentation software...
2018: PloS One
https://www.readbyqxmd.com/read/29721940/normative-retinal-thicknesses-in-common-animal-models-of-eye-disease-using-spectral-domain-optical-coherence-tomography
#10
Christy L Carpenter, Alice Y Kim, Amir H Kashani
Purpose This study demonstrates a standardized approach to measuring retinal thickness (RT) using spectral domain optical coherence tomography (SD-OCT) in commonly used animal models of disease and reports a normative data set for future use. Materials and Methods Twenty normal eyes of 4 adult animal models (5 rats, 5 rabbits, 5 canines, and 5 mini-pigs) were used. Manual measurements were made on the commercially available Heidelberg Spectralis™ SD-OCT to determine the total, inner, and outer retinal thickness (RT) at fixed distances from the optic nerve head (ONH) (1, 2, 3, 4, 5, and 6 mm away) in order to control for normal variation in retinal thickness...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29718102/metabodiff-an-r-package-for-differential-metabolomic-analysis
#11
Andreas Mock, Rolf Warta, Steffen Dettling, Benedikt Brors, Dirk Jäger, Christel Herold-Mende
Summary: Comparative metabolomics comes of age through commercial vendors offering metabolomics for translational researchers outside the mass spectrometry field. The MetaboDiff packages aims to provide a low-level entry to differential metabolomic analysis with R by starting off with the table of metabolite measurements. As a key functionality, MetaboDiffs offers the exploration of sample traits in a data-derived metabolic correlation network. Availability and Implementation: The MetaboDiff R package is platform-independent, available at http://github...
April 26, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29708635/shifting-metabolic-priorities-among-key-protistan-taxa-within-and-below-the-euphotic-zone
#12
Sarah K Hu, Zhenfeng Liu, Harriet Alexander, Victoria Campbell, Paige E Connell, Sonya T Dyhrman, Karla B Heidelberg, David A Caron
A metatranscriptome study targeting the protistan community was conducted off the coast of Southern California, at the San Pedro Ocean Time-series station at the surface, 150 m (oxycline), and 890 m to link putative metabolic patterns to distinct protistan lineages. Comparison of relative transcript abundances revealed depth-related shifts in the nutritional modes of key taxonomic groups. Eukaryotic gene expression in the sunlit surface environment was dominated by phototrophs, such as diatoms and chlorophytes, and high abundances of transcripts associated with synthesis pathways (e...
April 30, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29706852/associations-of-branched-chain-amino-acids-with-parameters-of-energy-balance-and-survival-in-colorectal-cancer-patients-results-from-the-colocare-study
#13
Mahmoud Delphan, Tengda Lin, David B Liesenfeld, Johanna Nattenmüller, Jürgen T Böhm, Biljana Gigic, Nina Habermann, Lin Zielske, Petra Schrotz-King, Martin Schneider, Alexis Ulrich, Hans-Ulrich Kauczor, Cornelia M Ulrich, Jennifer Ose
Background: Branched-chain amino acids (BCAA) have been previously linked to survival in colorectal cancer (CRC) patients. It is unclear whether BCAAs are prognostic biomarkers or surrogate markers for energy balance. Objectives: We aimed to determine correlations of BCAAs with markers of energy balance over time and to investigate prognostic significance of BCAAs in CRC. Methods: We used urinary samples from newly diagnosed CRC patients [n=163; (stage I - IV)] from the ColoCare study in Heidelberg, Germany, collected at surgery (n=163), 6 (n=83) and 12 months follow-up (n=54)...
March 2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29706620/the-effect-of-trabeculectomy-surgery-on-the-central-visual-field-in-patients-with-glaucoma-using-microperimetry-and-optical-coherence-tomography
#14
Gokulan Ratnarajan, Jasleen K Jolly, Imran H Yusuf, John F Salmon
PURPOSE: To determine the functional and structural effects of trabeculectomy surgery on patients with advanced glaucoma and central visual field defects in the early post-operative period. METHODS: Thirty consecutive adult subjects with advanced glaucoma requiring trabeculectomy surgery and an established visual field defect within 10° of fixation underwent microperimetry (MAIA MP-1, CenterVue, Padova, Italy) and optic disc optical coherence tomography (OCT) imaging (Spectralis, Heidelberg Engineering, Germany) pre-operatively, and 1 month and 3 months following trabeculectomy surgery...
April 30, 2018: Eye
https://www.readbyqxmd.com/read/29706619/microperimetry-and-optical-coherence-tomography-imaging-in-the-fellow-eye-of-patients-with-unilateral-focal-ischaemic-glaucoma
#15
Imran H Yusuf, Jasleen K Jolly, Gokulan Ratnarajan, John F Salmon
PURPOSE: To determine whether microperimetry or optical coherence tomography (OCT) imaging can detect early disease in the fellow eye of patients with unilateral focal ischaemic glaucoma. METHODS: Thirty-seven consecutive adult patients with unilateral focal ischaemic glaucoma with a unilateral split-fixation visual field defect on standard automated perimetry (SAP) with normal SAP in the fellow eye were selected. All patients underwent microperimetry (MAIA, CenterVue, Italy) of the central 10 degrees and OCT imaging (Spectralis, Heidelberg Engineering, Germany) of the retinal nerve fibre layer of both eyes...
April 30, 2018: Eye
https://www.readbyqxmd.com/read/29703240/temporal-phenotyping-of-circulating-microparticles-after-trauma-a-prospective-cohort-study
#16
Matthias Fröhlich, Nadine Schäfer, Michael Caspers, Julia K Böhm, Ewa K Stürmer, Bertil Bouillon, Marc Maegele
BACKGROUND: After severe polytrauma the dynamic process of coagulation may deteriorate towards a trauma-induced coagulopathy (TIC) promoting a dramatic increase in morbidity and mortality. Recent evidence suggests that microparticles (MPs) play a pivotal role at the interface between cellular and plasmatic coagulation systems. However, the impact of MPs on functional coagulation has not been clarified yet in the setting of traumatic injuries. We assessed the temporal patterns of circulating MP concentrations including their cellular origin in the context of clinical presentation and global coagulation assays...
April 27, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29698513/complications-and-risk-management-in-the-use-of-the-reaming-irrigator-aspirator-ria-system-ria-is-a-safe-and-reliable-method-in-harvesting-autologous-bone-graft
#17
Patrick Haubruck, Julian Ober, Raban Heller, Matthias Miska, Gerhard Schmidmaier, Michael C Tanner
BACKGROUND: Autologous bone grafting (ABG) remains the gold standard for augmentation of bone defects. The RIA system has become more prevalent, but evidence regarding risk management and complications remain scarce. This study presents the risk management and complications associated with RIA in the largest single-center case series to date. METHODS: All records, operative notes, lab data and radiographs of patients receiving a RIA procedure at Heidelberg´s University Hospital between 01/01/2010 and 31/12/2016 were reviewed...
2018: PloS One
https://www.readbyqxmd.com/read/29697600/optical-coherence-tomography-angiography-in-the-diagnosis-and-follow-up-of-retinal-arterial-macroaneurysms
#18
Polina Astroz, Alexandra Miere, Salomon Yves Cohen, Giuseppe Querques, Eric H Souied
PURPOSE: To describe optical coherence tomography angiography (OCTA) findings in retinal arterial macroaneurysm (RAM) associated with macular edema and to correlate OCTA findings with conventional multimodal imaging. METHODS: The clinical course, conventional multimodal imaging findings including fundus color photography, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), fluorescein angiography (Heidelberg Engineering), and OCTA (Optovue, Inc, Freemont, CA) findings at baseline and during the follow-up of two eyes (two patients) with symptomatic RAM associated with macular edema were documented...
April 24, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29687621/changes-in-the-prevalence-of-salmonella-serovars-associated-swine-production-and-correlations-of-avian-bovine-and-swine-associated-serovars-with-human-associated-serovars-in-the-united-states-1997-2015
#19
C Yuan, A Krull, C Wang, M Erdman, P J Fedorka-Cray, C M Logue, A M O'Connor
As Salmonella enterica is an important pathogen of food animals, surveillance programmes for S. enterica serovars have existed for many years in the United States. Surveillance programmes serve many purposes, one of which is to evaluate alterations in the prevalence of serovars that may signal changes in the ecology of the target organism. The primary aim of this study was to evaluate changes in the proportion of S. enterica serovars isolated from swine over a near 20-year observation period (1997-2015) using four longitudinal data sets from different food animal species...
April 23, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29687335/prospective-randomized-single-masked-parallel-study-exploring-the-effects-of-a-preservative-free-ophthalmic-solution-containing-hyaluronic-acid-0-4-and-taurine-0-5-on-the-ocular-surface-of-glaucoma-patients-under-multiple-long-term-topical-hypotensive-therapy
#20
Gloria Roberti, Luca Agnifili, Francesca Berardo, Ivano Riva, Michele Figus, Gianluca Manni, Luciano Quaranta, Francesco Oddone
INTRODUCTION: To compare the effects of a preservative-free (PF) ophthalmic solution containing hyaluronic acid (HA) 0.4% and taurine (TAU) 0.5% with those of a PF ophthalmic solution containing HA 0.2% on ocular surface signs, symptoms, and morphological parameters in glaucoma patients under multiple long-term topical hypotensive therapy. METHODS: Eligible patients underwent evaluation of ocular surface parameters by ocular surface disease index (OSDI) and glaucoma symptom scale (GSS) questionnaires, breakup time test (BUT), Schirmer I test, corneal and conjunctival staining (Oxford scale), and conjunctival in vivo confocal microscopy (Heidelberg Retina Tomograph 3, Heidelberg Engineering GmbH, Heidelberg, Germany)...
April 23, 2018: Advances in Therapy
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