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https://www.readbyqxmd.com/read/29590081/metabolic-syndrome-leptin-insulin-resistance-and-uric-acid-a-trinomial-foe-for-algerian-city-dweller-adolescents-health
#1
Hamida Bouhenni, Hadjer Daoudi, Haidar Djemai, Abdelkader Rouabah, Damien Vitiello, Leila Rouabah
Background Adolescence is one of the critical periods where increased risk for long-term obesity-related complications is an important health concern. This highlights the need to perform early diagnostics based on precise biomarkers to decrease the risk of complications in adolescents with obesity. Objective To determine the relationships between serum levels of uric acid (UA), leptin and insulin with metabolic syndrome (MS) components in Algerian adolescents. Subjects Nondiabetic adolescents (n = 204)...
March 28, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29558683/vanadium-iv-chlorodipicolinate-alleviates-hepatic-lipid-accumulation-by-inducing-autophagy-via-the-lkb1-ampk-signaling-pathway-in-vitro-and-in-vivo
#2
Ying Huang, Fang Liu, Fang Zhang, Pingsheng Liu, Tao Xu, Wenjun Ding
Numerous studies have demonstrated that vanadium compounds are able to improve lipemia and triglyceridemia in both humans and animals. However, the molecular mechanism remains elusive. The present study was conducted to investigate the anti-hyperlipidemic effect of vanadium(IV) complex with 4-chlorodipicolinic acid (VOdipic-Cl)-induced autophagy on hepatic lipid accumulation. To explore the possible underlying mechanisms, primary rat hepatocytes, human hepatoma cell line HepG2, and liver tissue from C57BL/6 mice fed a high-fat diet (HFD) were used...
March 14, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29501869/pravastatin-improves-risk-factors-but-not-ischaemic-tolerance-in-obese-rats
#3
Massa Oi, Daniel Donner, Jason Peart, Belinda Beck, Lauren Wendt, John P Headrick, Eugene F du Toit
Statins are effective in management of dyslipidaemia, and a cornerstone of CVD prevention strategies. However, the impacts of their pleiotropic effects on other cardiovascular risk factors and myocardial responses to infarction are not well characterised. We hypothesised that pravastatin treatment in obesity improves lipid profiles, insulin-resistance and myocardial resistance to ischaemia/reperfusion (I/R) injury. Wistar rats were fed a control (C) chow or high carbohydrate and fat diet (HCFD) for 16 weeks with vehicle or pravastatin (prava 7...
May 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29437170/carbohydrate-metabolism-and-gene-expression-of-sirtuin-1-in-healthy-subjects-after-sacha-inchi-oil-supplementation-a-randomized-trial
#4
A N Alayón, J G Ortega Avila, I Echeverri Jiménez
BACKGROUND: The postprandial stage is related to cardiovascular risk and it depends on the type of meal consumed. We study the effects of Sacha inchi oil on the postprandial glycemic state caused by meals rich in saturated fat. METHODS AND RESULTS: A double blind randomized trial in which 42 adult men ingested two breakfasts rich in saturated fat, one of them containing additionally 15 mL of Sacha inchi oil. Blood samples were obtained before or after 1 and 4 hours post-ingestion to quantify glucose, insulin and lipid profile in serum...
February 13, 2018: Food & Function
https://www.readbyqxmd.com/read/29415837/parenteral-nutrition-associated-cholestasis-and-triglyceridemia-in-surgical-term-and-near-term-neonates-a-pilot-randomized-controlled-trial-of-two-mixed-intravenous-lipid-emulsions
#5
Luís Pereira-da-Silva, Sara Nóbrega, Maria Luísa Rosa, Marta Alves, Ana Pita, Daniel Virella, Ana Luísa Papoila, Micaela Serelha, Gonçalo Cordeiro-Ferreira, Berthold Koletzko
BACKGROUND: Cholestasis is a common complication in infants receiving prolonged parenteral nutrition (PN). We studied the effects of two intravenous lipid emulsions composed with either 30% soybean oil, 30% medium-chain triglycerides (MCT), 25% olive oil, and 15% fish oil (SMOF) or with 50% MCT and 50% soybean oil n-6 (MCT/SOY) on the incidence of cholestasis in surgical term and near-term neonates. METHODS: A single-center, double-blinded, randomized controlled trial compared the incidence of cholestasis using either SMOF or MCT/SOY in neonates born at gestational age ≥34 weeks undergoing major surgery...
December 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29408683/aberrant-apolipoprotein-c-iii-glycosylation-in-glycogen-storage-disease-type-iii-and-ix
#6
Nina Ondruskova, Tomas Honzik, Hana Kolarova, Zuzana Pakanova, Jan Mucha, Jiri Zeman, Hana Hansikova
INTRODUCTION: Apolipoprotein C-III (ApoC-III) is a mostly liver-derived serum O-glycoprotein, which is used, along with an N-glycoprotein transferrin (TF), as a marker in the biochemical screening for congenital disorders of glycosylation (CDG). However, it is increasingly evident that secondary glycosylation abnormalities might occur in other, non-CDG metabolic diseases. MATERIAL AND METHODS: Here we examined the glycosylation status of serum TF and Apo-CIII by isoelectric focusing, SDS-PAGE and MALDI TOF mass spectrometry in our group of 24 patients with various types of glycogen storage disorders (GSD; types 0, Ia, nonIa, III and IX)...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29365866/long-term-high-carbohydrate-parenteral-nutrition-does-not-have-negative-effect-on-the-hepatic-function-and-triglyceridemia
#7
Pavel Skorepa, Joao Fortunato, Vladimir Blaha, Lubos Sobotka, Jan Horacek
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365835/the-magnitude-of-postprandial-triglyceridemia-conditions-the-cholesterol-content-decrease-of-hdl-subclasses-after-a-fat-diet-intake
#8
Oscar Pérez-Méndez, Armando Quintanilla-Cantú, Paola Peña-De-La-Sancha
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29334162/prevalence-of-metabolic-syndrome-in-children-with-moderate-to-severe-psoriasis-treated-with-tnf-inhibitors-in-comparison-to-conventional-agents
#9
Nawaf Al Mutairi, Dhuha Alrqobah, Nasser Haji Hussain
Association of childhood psoriasis with metabolic syndrome has not been studied well. TNF-alfa contributes to the inflammation seen in metabolic syndrome, and recently etanercept has shown to reduce the levels of inflammatory markers. Assessment of prevalence of metabolic syndrome in juvenile psoriasis patients in Kuwait. We included 236 patients with moderate to severe psoriasis below 18 years treated for at least 24 weeks with TNF inhibitors (Group A), and equal number of age and sex matched cases treated with conventional medications (Group B)...
January 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29258212/dietary-patterns-in-relation-to-metabolic-syndrome-among-adults-in-poland-a-cross-sectional-study
#10
Edyta Suliga, Dorota Kozieł, Elżbieta Cieśla, Dorota Rębak, Stanisław Głuszek
In several populations the associations between diet and the risk of metabolic syndrome have not been fully examined yet. The aim of the study is to identify the main dietary patterns among Polish adults and the evaluation of the relationships of these patterns with metabolic syndrome and its components. The study was conducted on a group of 7997 participants, aged between 37 and 66 years old. Dietary patterns were identified by factor analysis. Metabolic syndrome was defined according to the International Diabetes Federation...
December 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29236165/polyphenol-rich-curry-made-with-mixed-spices-and-vegetables-benefits-glucose-homeostasis-in-chinese-males-polyspice-study-a-dose-response-randomized-controlled-crossover-trial
#11
Sumanto Haldar, Siok Ching Chia, Sze Han Lee, Joseph Lim, Melvin Khee-Shing Leow, Eric Chun Yong Chan, Christiani Jeyakumar Henry
PURPOSE: To investigate acute effects of two doses of a polyphenol-rich curry made with seven different spices and four base vegetables, eaten with white rice, on 24 h glucose response, postprandial insulinemia, triglyceridemia and 24 h urinary total polyphenol excretion (TPE). METHODS: Randomized, controlled, dose-response crossover trial in healthy, Chinese men [n = 20, mean ± standard deviation (SD) age 23.7 ± 2.30 years, BMI 23.0 ± 2.31 kg/m2 ] who consumed test meals matched for calories, macronutrients and total vegetables content, consisting either Dose 0 Control (D0C) or Dose 1 Curry (D1C) or Dose 2 Curry (D2C) meal...
December 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29190548/supplementation-with-polyunsaturated-fatty-acids-in-pregnant-rats-with-mild-diabetes-normalizes-placental-ppar%C3%AE-and-mtor-signaling-in-female-offspring-developing-gestational-diabetes
#12
Evangelina Capobianco, Daiana Fornes, Sabrina Lorena Roberti, Theresa L Powell, Thomas Jansson, Alicia Jawerbaum
Maternal diabetes impairs fetoplacental development and programs metabolic diseases in the offspring. We have previously reported that female offspring of pregnant rats with mild diabetes develop gestational diabetes mellitus (GDM) when they become pregnant. Here, we studied the effects of supplementation with polyunsaturated fatty acids (PUFAs) in pregnant mild diabetic rats (F0) by feeding a 6% safflower-oil-enriched diet from day 1 to 14 followed by a 6% chia-oil-enriched diet from day 14 of pregnancy to term...
March 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29183845/comparison-of-adiposity-indicators-associated-with-fasting-state-insulinemia-triglyceridemia-and-related-risk-biomarkers-in-a-nationally-representative-adult-population
#13
Henry S Kahn, Yiling J Cheng
AIMS: We hypothesized that height-corrected abdominal size (supine sagittal abdominal diameter/height ratio [SADHtR] or waist circumference/height ratio [WHtR]) would associate more strongly than body mass index (BMI, weight/height2 ) with levels of fasting insulin, triglycerides, and three derived biomarkers of insulin resistance. METHODS: Anthropometry, including SAD by caliper, was collected on 4398 adults in the 2011-2014 National Health and Nutrition Examination Survey...
February 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29068532/alteration-of-liver-peroxisomal-and-mitochondrial-functionality-in-the-nzo-mouse-model-of-metabolic-syndrome
#14
Birgit Knebel, Simon Göddeke, Sonja Hartwig, Tina Hörbelt, Pia Fahlbusch, Hadi Al-Hasani, Sylvia Jacob, Cornelia Koellmer, Ulrike Nitzgen, Martina Schiller, Stefan Lehr, Jorg Kotzka
PURPOSE: Metabolic syndrome (MetS) consists of five risk factors: elevated blood pressure and fasting glucose, visceral obesity, dyslipidemia, and hypercholesterinemia. The physiological impact of lipid metabolism indicated as visceral obesity and hepatic lipid accumulation on MetS is still under debate. One major cause of disturbed lipid metabolism might be dysfunction of cellular organelles controlling energy homeostasis, i.e., mitochondria and peroxisomes. EXPERIMENTAL DESIGN: The New Zealand Obese (NZO) mouse model exhibits a polygenic syndrome of obesity, insulin resistance, triglyceridemia, and hypercholesterolemia that resembles human metabolic syndrome...
January 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28730827/glucose-added-to-a-fat-load-suppresses-the-postprandial-triglyceridemia-response-in-carriers-of-the-1131c-and-56g-variants-of-the-apoa5-gene
#15
K Zemánková, R Dembovská, J Piťha, J Kovář
Apolipoprotein A-V plays an important role in the determination of plasma triglyceride (TG) concentration. We aimed to determine whether polymorphisms -1131T>C (rs662799) and 56C>G (rs3135506) of the APOA5 gene have an impact on the course of postprandial lipemia induced by a fat load and a fat load with added glucose. Thirty healthy male volunteers, seven heterozygous for the -1131C variant and three for the 56G variant (HT) carriers, and 20 wild-type (WT) carriers underwent two 8-hour tests of postprandial lipemia - one after an experimental breakfast consisting of 75 g of fat and second after a breakfast consisting of 75 g of fat and 25 g of glucose...
November 24, 2017: Physiological Research
https://www.readbyqxmd.com/read/28721141/impact-of-25-hydroxyvitamin-d-free-and-bioavailable-fractions-of-vitamin-d-and-vitamin-d-binding-protein-levels-on-metabolic-syndrome-components
#16
Marta Pelczyńska, Teresa Grzelak, Marcelina Sperling, Paweł Bogdański, Danuta Pupek-Musialik, Krystyna Czyżewska
INTRODUCTION: Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other. MATERIAL AND METHODS: The studies were conducted on 79 people, including 52 with metabolic syndrome (MetS+) and 27 without it (MetS-)...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28544753/association-between-metabolic-syndrome-and-radiographic-hand-osteoarthritis-data-from-a-community-based-longitudinal-cohort-study
#17
Mette P Strand, Tuhina Neogi, Jingbo Niu, David T Felson, Ida K Haugen
OBJECTIVE: To explore whether metabolic syndrome and its components are associated with hand osteoarthritis (OA) using longitudinal data from the Framingham Study. METHODS: Our cross-sectional analyses included 1,089 persons (ages 50-75 years), of whom 785 had longitudinal radiographs obtained 7 years apart. Of these, 586 with no hand OA at baseline were included in analyses of hand OA incidence. We explored associations between metabolic syndrome and its components (central obesity, hypertension, diabetes mellitus, triglyceridemia, and low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with a Kellgren/Lawrence [K/L] grade of ≥2) using logistic regression analyses with adjustment for age, sex, and body mass index...
March 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/28501921/cranberry-vaccinium-macrocarpon-extract-treatment-improves-triglyceridemia-liver-cholesterol-liver-steatosis-oxidative-damage-and-corticosteronemia-in-rats-rendered-obese-by-high-fat-diet
#18
Thamara C Peixoto, Egberto G Moura, Elaine de Oliveira, Patrícia N Soares, Deysla S Guarda, Dayse N Bernardino, Xu Xue Ai, Vanessa da S T Rodrigues, Gabriela Rodrigues de Souza, Antonio Jorge Ribeiro da Silva, Mariana S Figueiredo, Alex C Manhães, Patrícia C Lisboa
PURPOSE: Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract (CE) can improve this dysfunction in HFD-induced obesity in rats since it has an important antioxidant activity. Here, we evaluated the effects of CE in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors, hepatic morphology and oxidative balance in a HFD model. METHODS: At postnatal day 120 (PN120), male Wistar rats were assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44...
May 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28443263/a-1-month-old-infant-with-chylomicronemia-due-to-gpihbp1-gene-mutation-treated-by-plasmapheresis
#19
Mo Kyung Jung, Juhyun Jin, Hyun Ok Kim, Ahreum Kwon, Hyun Wook Chae, Seok Jin Kang, Duk Hee Kim, Ho-Seong Kim
Chylomicronemia is a severe type of hypertriglyceridemia characterized by chylomicron accumulation that arises from a genetic defect in intravascular lipolysis. It requires urgent and proper management, because serious cases can be accompanied by pancreatic necrosis or persistent multiple organ failure. We present the case of a 1-month-old infant with chylomicronemia treated by plasmapheresis. His chylomicronemia was discovered incidentally when lactescent plasma was noticed during routine blood sampling during a hospital admission for fever and irritability...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28421793/effects-of-a-high-fat-meal-on-postprandial-incretin-responses-appetite-scores-and-ad-libitum-energy-intake-in-women-with-obesity
#20
Fernanda Rodrigues O Penaforte, Camila C Japur, Rosa W Diez-Garcia, Paula G Chiarello
BACKGROUND: Considering the possible role of triglycerides (TG), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the regulation of appetite, this study aimed to compare high fat meal-induced response of GIP and GLP-1, appetite scores and ad libitum energy intake in women with obesity, according to postprandial increment in triglyceridemia (∆TG).  Methods: Thirty-three no-diabetic women (BMI = 35.0 ± 3.2 kg.m-2) were divided into two groups: Group with ∆TG ≤ median were called "Low TG change -LTG" and ∆TG > median, "High TG change - HTG"...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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