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https://www.readbyqxmd.com/read/28443263/a-1-month-old-infant-with-chylomicronemia-due-to-gpihbp1-gene-mutation-treated-by-plasmapheresis
#1
Mo Kyung Jung, Juhyun Jin, Hyun Ok Kim, Ahreum Kwon, Hyun Wook Chae, Seok Jin Kang, Duk Hee Kim, Ho-Seong Kim
Chylomicronemia is a severe type of hypertriglyceridemia characterized by chylomicron accumulation that arises from a genetic defect in intravascular lipolysis. It requires urgent and proper management, because serious cases can be accompanied by pancreatic necrosis or persistent multiple organ failure. We present the case of a 1-month-old infant with chylomicronemia treated by plasmapheresis. His chylomicronemia was discovered incidentally when lactescent plasma was noticed during routine blood sampling during a hospital admission for fever and irritability...
March 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28421793/effects-of-a-high-fat-meal-on-postprandial-incretin-responses-appetite-scores-and-ad-libitum-energy-intake-in-women-with-obesity
#2
Fernanda Rodrigues O Penaforte, Camila C Japur, Rosa W Diez-Garcia, Paula G Chiarello
BACKGROUND: Considering the possible role of triglycerides (TG), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the regulation of appetite, this study aimed to compare high fat meal-induced response of GIP and GLP-1, appetite scores and ad libitum energy intake in women with obesity, according to postprandial increment in triglyceridemia (∆TG).  Methods: Thirty-three no-diabetic women (BMI = 35.0 ± 3.2 kg.m-2) were divided into two groups: Group with ∆TG ≤ median were called "Low TG change -LTG" and ∆TG > median, "High TG change - HTG"...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28411504/severe-insomnia-is-associated-with-hypertriglyceridemia-in-women-with-major-depression-treated-in-psychiatry-settings
#3
Jean-François Costemale-Lacoste, Séverine Trabado, Céline Verstuyft, Khalil El Asmar, Florence Butlen-Ducuing, Romain Colle, Florian Ferreri, Mircea Polosan, Emmanuel Haffen, Beverley Balkau, Bruno Falissard, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble
BACKGROUND: Hypertriglyceridemia (HTG) is a cardiovascular risk factor. In the general population, elevated fasting triglyceridemia (TG) is associated with insomnia. Since insomnia is a core symptom of Major Depressive Episodes (MDE), we studied the association of severe insomnia with HTG in major depression. METHODS: We used the baseline data of the METADAP cohort, comprising 624 patients with a current MDE in a context of Major Depressive Disorder treated in psychiatry settings, without current alcohol use disorders...
April 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28270893/association-of-whole-blood-viscosity-with-metabolic-syndrome-in-type-2-diabetic-patients-independent-association-with-post-breakfast-triglyceridemia
#4
Satomi Minato, Akiko Takenouchi, Junko Uchida, Ayaka Tsuboi, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: Associations of whole blood viscosity (WBV) with metabolic syndrome (MS) have not been extensively studied in patients with type 2 diabetes. METHODS: Intrapersonal means of 12 measurements of waist circumference, blood pressure (BP) and high-density lipoprotein cholesterol and those of six measurements of fasting and post-breakfast triglycerides (TG) during 12 months were calculated in a cohort of 168 patients with type 2 diabetes. Based on these means, MS was diagnosed according to the modified National Cholesterol Education Program Adult Treatment Panel III criteria with the Asian definition of abdominal obesity...
April 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28223816/prevalence-of-metabolic-syndrome-in-adolescents-living-in-mthatha-south-africa
#5
Morongwe Annah Sekokotla, Nandu Goswami, Constance Rufaro Sewani-Rusike, Jehu Erapu Iputo, Benedicta Ngwenchi Nkeh-Chungag
OBJECTIVE: Metabolic syndrome (MetS), defined as the clustering of three of five risk factors (hypertension, obesity, triglyceridemia, dyslipidemia and hyperglycemia), is being increasingly mentioned among children and adolescents despite there being no consensus on how it should be defined in this set of population. Furthermore, very few studies have focused on MetS in children and adolescents in sub-Saharan populations. This study, therefore, aimed at determining the prevalence of the MetS and contributing risk in adolescents living in Mthatha, South Africa...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28201738/a-novel-apoc2-missense-mutation-causing-apolipoprotein-c-ii-deficiency-with-severe-triglyceridemia-and-pancreatitis
#6
Masako Ueda, Richard L Dunbar, Anna Wolska, Tracey U Sikora, Maria Del Rosario Escobar, Naomi Seliktar, Emil deGoma, Stephanie DerOhannessian, Linda Morrell, Adam D McIntyre, Francis Burke, Denis Sviridov, Marcelo Amar, Robert D Shamburek, Lita Freeman, Robert A Hegele, Alan T Remaley, Daniel J Rader
No abstract text is available yet for this article.
February 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28122929/a-systematic-review-of-the-effects-of-plant-compared-with-animal-protein-sources-on-features-of-metabolic-syndrome
#7
REVIEW
Tristan Chalvon-Demersay, Dalila Azzout-Marniche, Judith Arfsten, Léonie Egli, Claire Gaudichon, Leonidas G Karagounis, Daniel Tomé
Dietary protein may play an important role in the prevention of metabolic dysfunctions. However, the way in which the protein source affects these dysfunctions has not been clearly established. The aim of the current systematic review was to compare the impact of plant- and animal-sourced dietary proteins on several features of metabolic syndrome in humans. The PubMed database was searched for both chronic and acute interventional studies, as well as observational studies, in healthy humans or those with metabolic dysfunctions, in which the impact of animal and plant protein intake was compared while using the following variables: cholesterolemia and triglyceridemia, blood pressure, glucose homeostasis, and body composition...
January 25, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28097106/postmeal-triglyceridemia-and-variability-of-hba1c-and-postmeal-glycemia-were-predictors-of-annual-decline-in-estimated-glomerular-filtration-rate-in-type-2-diabetic-patients-with-different-stages-of-nephropathy
#8
Ayaka Tsuboi, Akiko Takenouchi, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: This study examined associations of annual glycemic variability and postprandial dysmetabolism with annual decline in estimated glomerular filtration rate (eGFR) in type 2 diabetic patients with different stages of nephropathy. METHODS: Intrapersonal mean and coefficient of variation (CV) of HbA1c, fasting and postmeal concentrations of plasma glucose (FPG and PMPG, respectively) and serum triglycerides (FTG and PMTG, respectively) during the first 12 months after enrollment were calculated in a cohort of 168 type 2 diabetic patients: 53 with optimal albumin/creatinine ratio (ACR < 10 mg/g), 62 with high normal ACR (10-29 mg/g) and 53 with elevated ACR (≧30 mg/g)...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27847194/small-hdl-subclasses-become-cholesterol-poor-during-postprandial-period-after-a-fat-diet-intake-in-subjects-with-high-triglyceridemia-increases
#9
Armando Quintanilla-Cantú, Paola Peña-de-la-Sancha, Cristobal Flores-Castillo, Ana María Mejía-Domínguez, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Rocío Bautista-Pérez, Reyna Esmeralda Enriquez-Calderón, Marco Antonio Juárez-Oropeza, José Manuel Fragoso, Gilberto Vargas-Alarcón, Oscar Pérez-Méndez
BACKGROUND: Postprandial triglyceridemia may transitory affect the structure of HDL subclasses and probably their antiatherogenic properties but little is known in this field. We analyzed the HDL subclasses lipid content along postprandial period. METHODS: Fifteen metabolic syndrome (MS) patients and 15 healthy controls were enrolled. HDL were isolated from plasma samples obtained at fasting and every 2-h up to 8-h, after a 75-g fat meal. Cholesterol (C), triglycerides (TAG), and phospholipid (Ph) plasma concentrations of five HDL subclasses were determined by densitometry of electrophoresis gels enzymatically stained...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27842906/metformin-preconditioned-adipose-derived-mesenchymal-stem-cells-is-a-better-option-for-the-reversal-of-diabetes-upon-transplantation
#10
Nitya Shree, Ramesh R Bhonde
Metformin is used worldwide as an insulin sensitizer. Adipose derived mesenchymal stem cells have shown promising results in the reducing hyperglycemia. We examined whether preconditioning of adipose derived mesenchymal stem cells (ASCs) with metformin could have a better therapeutic value for the reversal of type 2 diabetes. We compared the effect of metformin, ASCs and metformin preconditioned ASCs (MetASCs) in high fat diet induced C57BL/6 mice by injecting the cells intramuscularly only once where as metformin was given at a concentration of 300mg per kg body weight orally daily...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27824243/hypertriglyceridemic-waist-in-type-1-diabetes-patients-prevalence-and-related-factors
#11
Mercè Fernández-Miró, Juan J Chillarón, Mercè Albareda, Sara Fontserè, Cristina Colom, Lluís Vila, Juan Pedro-Botet, Juana A Flores LE-Roux
BACKGROUND: The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro- and macrovascular complications. METHODS: A cross-sectional study was conducted in men with T1D to assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism...
November 8, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27822171/grape-seed-powder-improves-renal-failure-of-chronic-kidney-disease-patients
#12
Khaoula Turki, Kamel Charradi, Habib Boukhalfa, Monia Belhaj, Ferid Limam, Ezzedine Aouani
Chronic kidney disease (CKD) is a syndrome characterized by progressive and irreversible deterioration of renal function linked to slow destruction of renal parenchyma, eventually terminating in death when sufficient number of nephrons are damaged. Oxidative stress is commonly observed in CKD patients resulting from an imbalance between overproduction of reactive oxygen species (ROS) and impairment of defence mechanisms. Grape seed extract (GSE) is a polyphenolic mixture exhibiting antioxidant and anti-inflammatory properties...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27737397/hypertriglyceridemia-is-there-a-role-for-prophylactic-apheresis-a-case-report
#13
Ana Rita Francisco, Inês Gonçalves, Fátima Veiga, Mónica Mendes Pedro, Fausto J Pinto, Dulce Brito
Severe hypertriglyceridemia has been consistently associated with an increased risk of cardiovascular disease and other complications, namely acute pancreatitis. We report a case of a 64 year-old woman with hypertrophic cardiomyopathy and metabolic syndrome with triglyceride level of 3260 mg/dL. Plasma exchange was performed with simultaneous medical treatment to achieve a rapid and effective lowering of triglycerides in order to prevent clinical complications. After three plasmapheresis sessions a marked reduction in triglyceride and total cholesterol levels was observed...
July 2016: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/27590876/significantly-greater-triglyceridemia-in-black-african-compared-to-white-european-men-following-high-added-fructose-and-glucose-feeding-a-randomized-crossover-trial
#14
RANDOMIZED CONTROLLED TRIAL
Louise M Goff, Martin B Whyte, Miriam Samuel, Scott V Harding
BACKGROUND: Black African (BA) populations are losing the cardio-protective lipid profile they historically exhibited, which may be linked with increasing fructose intakes. The metabolic effects of high fructose diets and how they relate to blood lipids are documented for Caucasians, but have not been described in BA individuals. OBJECTIVE: The principle objective of this pilot study was to assess the independent impacts of high glucose and fructose feeding in men of BA ancestry compared to men of White European (WE) ancestry on circulating triglyceride (TG) concentrations...
September 2, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27503720/analysis-of-the-energetic-metabolism-in-cyclic-bedouin-goats-capra-hircus-nychthemeral-and-seasonal-variations-of-some-haematochemical-parameters-in-relation-with-body-and-ambient-temperatures
#15
Mouna Malek, Zaina Amirat, Farida Khammar, Mounira Khaldoun
Several studies have examined changes in some haematochemical parameters as a function of the different physiological status (cyclic, pregnant and lactating) of goats, but no relevant literature has exhaustively investigated these variations from anestrous to estrous stages in cyclic goats. In this paper, we report nychthemeral and seasonal variations in ambient and body temperatures, and in some haematochemical parameters (glycemia, cholesterolemia, triglyceridemia, creatininemia and uremia) measured during summer, winter and spring, in seven (7) experimental cyclic female Bedouin goats (Capra hircus) living in the Béni-Abbès region (Algerian Sahara desert)...
August 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27437032/visceral-adiposity-syndrome
#16
REVIEW
Heno F Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M Consolim-Colombo, Brent M Egan
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 years. Nowadays, blood pressure, body mass index/abdominal circumference, glycemia, triglyceridemia, and HDL-cholesterol concentrations are considered in the definition of Metabolic syndrome, referred as Visceral adiposity syndrome (VAS) in the present review. However, more than 250 years ago an association between visceral and mediastinal obesity with hypertension, gout, and obstructive apnea had already been recognized...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27414692/evaluating-the-safety-of-phytosterols-removed-perilla-seed-oil-based-lipid-emulsion
#17
Zhenhua Yang, Tianyang Ren, De Lu, Haiyan Guo, Wanqiu Li, Chenglong Huang, Haibing He, Dongchun Liu, Xing Tang
OBJECTIVES: The aim of this study was to ascertain the potential toxicity of perilla seed oil-based lipid emulsion (POLE) caused by phytosterols and confirm the efficacy of the technique for removing phytosterols from perilla seed oil, and evaluate the safety of a low phytosterol POLE in a long-term tolerance study in dogs. METHODS: A comparison between a soybean oil lipid emulsion (Intralipid group A) and POLE with high (group B) versus low (group C) levels of phytosterols was made with regard to their effects on the general condition, hematological and biochemical parameters, urinalysis and histopathological changes in nine dogs receiving daily infusions for four weeks at dosage levels of 6, 6, 9 g fat /kg...
October 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27269375/human-monocytes-and-macrophages-undergo-m1-type-inflammatory-polarization-in-response-to-high-levels-of-glucose
#18
Israel Torres-Castro, Úrsula D Arroyo-Camarena, Camilo P Martínez-Reyes, Angélica Y Gómez-Arauz, Yareth Dueñas-Andrade, Joselín Hernández-Ruiz, Yadira L Béjar, Verónica Zaga-Clavellina, Jorge Morales-Montor, Luis I Terrazas, Julia Kzhyshkowska, Galileo Escobedo
Emerging data suggest that elevated glucose may promote inflammatory activation of monocytic lineage cells with the ability to injure vascular endothelial tissue of diabetic patients, however evidence in primary human monocytes and macrophages is still insufficient. We investigated the effect of high glucose concentration on the inflammatory capacity of human macrophages in vitro and examined whether similar responses were detectable in circulating monocytes from prediabetic patients. Primary monocytes were isolated from healthy blood donors and differentiated into macrophages...
August 2016: Immunology Letters
https://www.readbyqxmd.com/read/27241191/obesogen-effects-after-perinatal-exposure-of-4-4-sulfonyldiphenol-bisphenol-s-in-c57bl-6-mice
#19
L Ivry Del Moral, L Le Corre, H Poirier, I Niot, T Truntzer, J-F Merlin, P Rouimi, P Besnard, R Rahmani, M C Chagnon
Bisphenol A were removed from consumer products and replaced by chemical substitutes such as Bisphenol S (BPS). Based on their structural similarity, BPS may be obesogen like Bisphenol A in mice. Our objective was to determine the impact of BPS on lipid homeostasis in C57Bl/6 mice after perinatal and chronic exposure. Pregnant mice were exposed to BPS via the drinking water (0.2; 1.5; 50μg/kg bw/d). Treatment began at gestational day 0 and continued in offspring up to 23-weeks old. Then, offspring mice were fed with a standard or high fat diet...
May 16, 2016: Toxicology
https://www.readbyqxmd.com/read/26985241/clinical-and-laboratory-data-of-a-large-series-of-patients-with-congenital-generalized-lipodystrophy
#20
Josivan G Lima, Lucia Helena C Nobrega, Natalia Nobrega de Lima, Maria Goretti do Nascimento Santos, Maria F P Baracho, Selma Maria Bezerra Jeronimo
BACKGROUND: Berardinelli-Seip congenital lipodystrophy (BSCL) was initially described by Berardinelli in Brazil in 1954 and 5 years later by Seip in Norway. It is an autosomal recessive disease that leads to a generalized deficit of body fat, evolving with diabetes and hypertriglyceridemia. The aim of this study was to describe the clinical and laboratory characteristics of a large series of patients with BSCL. METHODS: This is a cross-sectional study of patients with BSCL...
2016: Diabetology & Metabolic Syndrome
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