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potassium citrate

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https://www.readbyqxmd.com/read/28904440/primary-hyperoxaluria-type-1-with-homozygosity-for-a-double-mutated-agxt-allele-in-a-2-year-old-child
#1
S Krishnamurthy, G B Kartha, V S Venkateswaran, M Prasannakumar, S Mahadevan, M Gowda, A Pelle, D Giachino
Primary hyperoxaluria (PH) Type 1 is a rare, genetic disorder caused by deficiency of the liver enzyme alanine-glyoxylate aminotransferase, which is encoded by AGXT gene. We report a 2-year-old South Indian Tamil child with nephrocalcinosis due to PH Type 1, in whom a homozygous genotype for two missense mutations in the AGXT gene was found: first, a C to G transversion (c. 32C>G) in exon 1 resulting in the amino acid substitution p.Pro11Arg; second, a T to A transversion (c. 167T>A) in exon 2 resulting in p...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28886192/influence-of-weight-status-on-24-hour-urine-composition-in-adults-without-urolithiasis-a-nationwide-study-based-on-a-chinese-han-population
#2
Tuo Deng, Zanlin Mai, Chao Cai, Xiaolu Duan, Wei Zhu, Tao Zhang, Wenqi Wu, Guohua Zeng
OBJECTIVES: This study sought to explore the influence of different body weight statuses on 24-hour urine compositions in adults without urolithiasis based on a nationwide study of a Chinese Han population. MATERIAL AND METHODS: Twenty-four-hour urine samples from 584 Chinese Han adults without urolithiasis in six cities were analyzed. The participants were divided into four body weight status types according to their body mass indices (BMIs) according to WHO guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/28882031/a-multiregional-italian-cohort-of-24-hour-urine-metabolic-evaluation-in-renal-stone-formers
#3
Francesco Esperto, Martino Marangella, Alberto Trinchieri, Michele Petrarulo, Roberto Miano
BACKGROUND: Nephrolithiasis is a common condition with several studies documenting an increased prevalence over the past four decades. EAU and AUA guidelines recommend 24-hour urine metabolic evaluation in high-risk stone formers. Aim of this study is to retrospectively evaluate the first three years of experience with Lithotest® (Biohealth Italia Srl, Turin, Italy) through the analysis of demographic, clinical and biochemical data collected from a large cohort of patients with kidney stones...
September 7, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28822453/-influence-of-saccharomyces-boulardii-sachets-combined-with-bismuth-quadruple-therapy-for-initial-helicobacter-pylori-eradication
#4
X Y Zhu, J Du, J Wu, L W Zhao, X Meng, G F Liu
Objective: To evaluate the efficacy and safety of Saccharomyces boulardii Sachets combined with bismuth quadruple therapy for initial Helicobacter pylori(H.pylori) eradication. Methods: From March 2014 to March 2015, 240 participants from the third hospital of Hebei medical university with H. pylori infection were recruited and randomized into three groups: Quadruple therapy group received bismuth potassium citrate 220 mg bid + Rabeprazole 10 mg bid + amoxicillin 1 000 mg bid+ furazolidone 100 mg bid for 10 days...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28762682/-use-of-citrate-in-patients-with-nephrolithiasis
#5
REVIEW
Martino Marangella
Citrate is a tricarboxylic acid and an intermediate metabolite of Krebs cycle. It contributes to oxidative metabolism of both kidney and liver. Alkaline sodium or potassium salts have the potential to increase alkaline reserve. In the kidney citrate is completely filtered at the glomerulus, undergoing to 10-40% tubular resorption. Renal insufficiency, even early, metabolic acidosis, potassium depletion induce hypocitraturia. Its importance in nephrolithiasis stems from its ability to form soluble complexes with calcium and to interfere with crystal formation, thus exerting a dual inhibition, thermodynamic and kinetic...
August 1, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28746044/various-glycolysis-inhibitor-containing-tubes-for-glucose-measurement-cannot-be-used-interchangeably-due-to-clinically-unacceptable-biases-between-them
#6
Andrea Saracevic, Lora Dukic, Gordana Juricic, Lara Milevoj Kopcinovic, Gorana Mirosevic, Ana-Maria Simundic
BACKGROUND: The aim of our study was to determine the difference between glucose concentration measured 30 min after venipuncture in ice-chilled heparin plasma sample and all currently available citrate buffer-containing tubes (Greiner Glucomedics, Greiner FC Mix and Sarstedt GlucoEXACT) and still widely used sodium fluoride/potassium oxalate (NaF/Kox) tubes from Greiner. METHODS: Blood was collected from 20 healthy volunteers and 20 patients with diabetes into LiH, NaF/KOx, Glucomedics, FC mix and GlucoEXACT tubes...
July 26, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28741656/biochemical-evaluation-of-storage-lesion-in-canine-packed-erythrocytes
#7
C R Wilson, M B Pashmakova, J A Heinz, M C Johnson, H M Minard, M A Bishop, J W Barr
OBJECTIVES: This study describes the biochemical changes - also known as the storage lesion - that occur in canine packed red blood cells during ex vivo storage. MATERIALS AND METHODS: Ten 125-mL units of non-leuco-reduced packed red blood cells in citrate phosphate dextrose adenine were obtained from a commercial blood bank within 24 hours of donation. Samples were aseptically collected on days 1, 4, 7, 14, 28, 35 and 42 for measurement of sodium, potassium, chloride, lactate, glucose, pH and ammonia concentrations...
July 25, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28715463/potassium-citrate-prevents-increased-osteoclastogenesis-resulting-from-acidic-conditions-implication-for-the-treatment-of-postmenopausal-bone-loss
#8
Donatella Granchi, Elena Torreggiani, Annamaria Massa, Renata Caudarella, Gemma Di Pompo, Nicola Baldini
The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the skeleton and the deterioration of bone microarchitecture. Alkalinization through supplementation with potassium citrate (K citrate) has been proposed to limit the osteopenia progression, even though its pharmacological activity in bone microenvironment is not well defined. We evaluated if K citrate was able to prevent the adverse effects that acidic milieu induces on bone cells...
2017: PloS One
https://www.readbyqxmd.com/read/28694730/topiramate-induced-metabolic-acidosis-and-kidney-stones-a-case-study
#9
Tomas Salek, Ivan Andel, Irena Kurfurstova
INTRODUCTION: The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones. MATERIALS AND METHODS: The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by potassium citrate, and after topiramate withdrawal are presented. Differential diagnosis of all possible causes of metabolic acidosis is discussed...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28679982/pseudomelanosis-duodeni-a-case-report
#10
Masaya Iwamuro, Shohei Oka, Hiromitsu Kanzaki, Takehiro Tanaka, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada
An 83-year-old Japanese man underwent esophagogastroduodenoscopy for screening purposes. He had a medical history of hypertension, chronic kidney disease, chronic heart failure, and chronic myeloid leukemia, and he had been taking the following medications:ferrous citrate, furosemide, spironolactone, tolvaptan, bisoprolol, nicorandil, warfarin, nilotinib, febuxostat, esomeprazole, digestive enzyme complex, ambroxol, carbocysteine, and potassium L-aspartate. Esophagogastroduodenoscopy revealed a brownish speckled pigmentation in the duodenal bulb...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28673194/evaluation-of-ctad-citrate-theophylline-adenosine-dipyridamole-as-a-universal-anticoagulant-in-dogs
#11
Fanny A Granat, Anne Geffré, Laetitia A Lucarelli, Jean-Pierre D Braun, Catherine Trumel, Nathalie H Bourgès-Abella
CTAD (citrate-theophylline-adenosine-dipyridamole) has been shown to be an almost universal anticoagulant in human and feline medicine, allowing most hematology, coagulation, and biochemical analyses. Forty canine blood specimens were collected in CTAD, EDTA, heparin, and citrate for hematology, biochemistry, and coagulation analyses. CTAD partially limited platelet aggregation observed in EDTA blood smears. CTAD specimens gave similar and well-correlated results for most variables of a complete blood cell count, except for mean corpuscular volume, which was moderately higher, and mean corpuscular hemoglobin concentration, which was moderately lower in CTAD than in EDTA; reticulocyte and platelet indexes were poorly correlated...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28672265/facile-preparation-of-intercrossed-stacked-porous-carbon-originated-from-potassium-citrate-and-their-highly-effective-adsorption-performance-for-chloramphenicol
#12
Sujun Tian, Jiangdong Dai, Yinhua Jiang, Zhongshuai Chang, Atian Xie, Jinsong He, Ruilong Zhang, Yongsheng Yan
Recently, antibiotics pollution has attracted more interests from many researches which causes potential risks on the ecosystem and human health. Herein, the porous carbons (PCs) was prepared by directly simultaneous carbonization/self-activation of potassium citrate at 750-900°C for chloramphenicol (CAP) removal from aqueous solution. The batch experiments were studied, which indicated that PCs prepared at 850°C, namely PCPCs-850, possessed excellent adsorption ability for CAP with a maximum adsorption amount of 506...
November 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28638159/in-vitro-evaluation-of-the-fresenius-kabi-catsmart-autotransfusion-system
#13
Melissa Alberts, Robert C Groom, Richard Walczak, Robert Kramer, Adrienne Karpiel, Jeanette Dieter, Lisa Sheth, Nathaniel H Greene, Edmund H Jooste
Use of autotransfusion systems to collect, wash, and concentrate shed blood during surgical procedures is a widely used method for reducing postoperative anemia and the need for blood transfusions. The aim of this study was to evaluate the CATSmart Continuous Autotransfusion System wash program performance with small (200 or 700 mL) and large volumes (1,000 mL) of shed blood and to determine non-inferiority of the CATSmart to the C.A.T.S (plus) system. Human whole blood was collected in citrate phosphate dextrose, diluted, and divided into two aliquots to be processed as a pair using the C...
June 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28578132/effect-of-electro-activated-aqueous-solutions-nisin-and-moderate-heat-treatment-on-the-inactivation-of-clostridium-sporogenes-pa-3679-spores-in-green-beans-puree-and-whole-green-beans
#14
Omar El Jaam, Ismail Fliss, Mohammed Aïder
In this work, the synergistic effect of electro-activated solutions (EAS) of potassium acetate and potassium citrate, nisin and moderate heat treatment to inactivate C. sporogenes PA 3679 spores was evaluated in green beans puree and whole green beans. Electro-activated solutions (EAS) of potassium acetate and potassium citrate were generated under 400 mA during 60 min. They were characterized by an oxidation-reduction potential (ORP) and pH values ranged from +300 to +1090 mV and 2.8 to 3.67, respectively...
May 31, 2017: Anaerobe
https://www.readbyqxmd.com/read/28537440/metabolic-characteristics-and-risks-associated-with-stone-recurrence-in-korean-young-adult-stone-patients
#15
Ho Won Kang, Sung Pil Seo, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Wun-Jae Kim, Sang-Cheol Lee
PURPOSE: The aim of this study was to assess the metabolic characteristics and risks of stone recurrence in young adult stone patients in Korea. PATIENTS AND METHODS: The medical records of 1532 patients presenting with renal or ureteric stones at our stone clinic between 1994 and 2015 were retrospectively reviewed. Patients were grouped according to age (young adult, 18-29 years; intermediate onset, 30-59 years; old age, ≥60 years) at first presentation, and measurements of clinicometabolic characteristics and risks of stone recurrence were compared...
August 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28529700/effect-of-citrus-based-products-on-urine-profile-a-systematic-review-and-meta-analysis
#16
Fakhri Rahman, Ponco Birowo, Indah S Widyahening, Nur Rasyid
Background. Urolithiasis is a disease with high recurrence rate, 30-50% within 5 years. The aim of the present study was to learn the effects of citrus-based products on the urine profile in healthy persons and people with urolithiasis compared to control diet and potassium citrate.  Methods. A systematic review was performed, which included interventional, prospective observational and retrospective studies, comparing citrus-based therapy with standard diet therapy, mineral water, or potassium citrate. A literature search was conducted using PUBMED, COCHRANE, and Google Scholar with "citrus or lemonade or orange or grapefruit or lime or juice" and "urolithiasis" as search terms...
2017: F1000Research
https://www.readbyqxmd.com/read/28509131/growth-hormone-therapy-for-a-patient-with-idiopathic-fanconi-syndrome-and-growth-hormone-deficiency
#17
Takayuki Okamoto, Yasuyuki Sato, Takeshi Yamazaki, Asako Hayashi, Toshiyuki Takahashi
Idiopathic Fanconi syndrome (FS) is characterized by a generalized dysfunction of the renal proximal tubules. Patients with FS often exhibit growth retardation due to complex factors, such as hypophosphatemia, metabolic acidosis, disturbed vitamin D metabolism and hypokalemia. To date, one FS patient has been reported to exhibit growth failure due to growth hormone deficiency (GHD), but the long-term clinical course of recombinant human GH (rhGH) therapy has not been reported. At 10 months of age, the patient was admitted to our hospital due to growth failure...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28458127/purification-of-%C3%AE-mannanase-derived-from-bacillus-subtilis-atcc-11774-using-ionic-liquid-as-adjuvant-in-aqueous-two-phase-system
#18
Nur Fazrin Husna Abdul Aziz, Sahar Abbasiliasi, Hui Suan Ng, Pongsathon Phapugrangkul, Mohamad Hafizi Abu Bakar, Yew Joon Tam, Joo Shun Tan
The partitioning of β-mannanase derived from Bacillus subtilis ATCC 11774 in aqueous two-phase system (ATPS) was studied. The ATPS containing different molecular weight of polyethylene glycol (PEG) and types of salt were employed in this study. The PEG/salt composition for the partitioning of β-mannanase was optimized using response surface methodology. The study demonstrated that ATPS consists of 25% (w/w) of PEG 6000 and 12.52% (w/w) of potassium citrate is the optimum composition for the purification of β-mannanase with a purification fold (PF) of 2...
June 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28441628/potassium-deficiency-affects-the-carbon-nitrogen-balance-in-cotton-leaves
#19
Wei Hu, Taylor D Coomer, Dimitra A Loka, Derrick M Oosterhuis, Zhiguo Zhou
Potassium (K) plays important roles in the metabolism of carbon (C) and nitrogen (N), but studies of K deficiency affecting C-N balance are lacking. This study explored the influence of K deficiency on C-N interaction in cotton leaves by conducting a field experiment with cotton cultivar DP0912 under two K rates (K0: 0 kg K2O ha(-1) and K67: 67 kg K2O ha(-1)) and a controlled environment experiment with K-deficient solution (K1: 0 mM K(+)) and K-sufficient solution (K2: 6 mM K(+)). The results showed that leaf K content, leaf number, leaf area, boll number, reproductive dry weight and total dry weight were significant lower under K deficiency (K0 or K1)...
June 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28422036/physicochemical-factors-of-the-urine-of-children-with-hypercalciuria
#20
Mercedes Ubetagoyena-Arrieta, Jorge Martínez Sáenz de Jubera, María Nieves Corera-Casty, Eduardo González Pérez-Yarza, Irati García-Albizua
OBJECTIVE: Hypercalciuria is a common lithogenic risk factor. The aim of this study was, first, to study the characteristics of urine biochemical factors of children with hypercalciuria (HC) and compare them with those of children without hypercalciuria. Second, to analyze the differences between children with HC and lithiasis (HCL) and children with HC and no lithiasis (HCNL). METHODS: The sample was composed by 111 cases with HC, divided into 2 groups: HCNL group, consisting of 93 cases with no personal history of kidney stones, and HCL group, 18 cases with personal history of kidney stones...
April 2017: Archivos Españoles de Urología
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