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melanoma and curcumin

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https://www.readbyqxmd.com/read/27746419/the-serum-pdgf-dependent-melanogenic-role-of-the-minute-level-of-the-oncogenic-kinase-pak1-in-melanoma-cells-proven-by-the-highly-sensitive-kinase-assay
#1
Pham Thi Be Tu, Binh Cao Quan Nguyen, Shinkichi Tawata, Cheong-Yong Yun, Eung Gook Kim, Hiroshi Maruta
We previously demonstrated that the oncogenic kinase PAK4, which both melanomas and normal melanocytes express at a very high level, is essential for their melanogenesis. In the present study, using the highly sensitive "Macaroni-Western" (IP-ATP-Glo) kinase assay, we investigated the melanogenic potential of another oncogenic kinase PAK1, which melanoma (B16F10) cells express only at a very minute level. After transfecting melanoma cells with PAK1-shRNA for silencing PAK1 gene, melanin content, tyrosinase activity, and kinase activity of PAK1 were compared between the wild-type and transfectants...
October 17, 2016: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/27618095/anticancer-efficacy-of-polyphenols-and-their-combinations
#2
REVIEW
Aleksandra Niedzwiecki, Mohd Waheed Roomi, Tatiana Kalinovsky, Matthias Rath
Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radicals damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds...
2016: Nutrients
https://www.readbyqxmd.com/read/27565688/oil-water-nano-emulsion-loaded-with-cobalt-ferrite-oxide-nanocubes-for-photo-acoustic-and-magnetic-resonance-dual-imaging-in-cancer-in-vitro-and-preclinical-studies
#3
Raffaele Vecchione, Vincenzo Quagliariello, Pierangela Giustetto, Dominic Calabria, Ayyappan Sathya, Roberto Marotta, Martina Profeta, Simone Nitti, Niccolò Silvestri, Teresa Pellegrino, Rosario V Iaffaioli, Paolo Antonio Netti
Dual imaging dramatically improves detection and early diagnosis of cancer. In this work we present an oil in water (O/W) nano-emulsion stabilized with lecithin and loaded with cobalt ferrite oxide (Co0.5Fe2.5O4) nanocubes for photo-acoustic and magnetic resonance dual imaging. The nanocarrier is responsive in in vitro photo-acoustic and magnetic resonance imaging (MRI) tests. A clear and significant time-dependent accumulation in tumor tissue is shown in in vivo photo-acoustic studies on a murine melanoma xenograft model...
August 24, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27502897/inhibition-of-autophagy-enhances-curcumin-united-light-irradiation-induced-oxidative-stress-and-tumor-growth-suppression-in-human-melanoma-cells
#4
Tianhui Niu, Yan Tian, Zhusong Mei, Guangjin Guo
Malignant melanoma is the most aggressive form of skin carcinoma, which possesses fast propagating and highly invasive characteristics. Curcumin is a natural phenol compound that has various biological activities, such as anti-proliferative and apoptosis-accelerating impacts on tumor cells. Unfortunately, the therapeutical activities of Cur are severely hindered due to its extremely low bioavailability. In this study, a cooperative therapy of low concentration Cur combined with red united blue light irradiation was performed to inspect the synergistic effects on the apoptosis, proliferation and autophagy in human melanoma A375 cell...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348749/xanthan-gum-stabilized-pegylated-gold-nanoparticles-for-improved-delivery-of-curcumin-in-cancer
#5
Omkara Swami Muddineti, Preeti Kumari, Srinivas Ajjarapu, Prit Manish Lakhani, Rishabh Bahl, Balaram Ghosh, Swati Biswas
In recent years, gold nanoparticles (AuNPs) have received immense interest in various biomedical applications including drug delivery, photothermal ablation of cancer and imaging agent for cancer diagnosis. However, the synthesis of AuNPs poses challenges due to the poor reproducibility and stability of the colloidal system. In the present work, we developed a one step, facile procedure for the synthesis of AuNPs from hydrogen tetrachloroaurate (III) hydrate (HAuCl4. 3H2O) by using ascorbic acid and xanthan gum (XG) as reducing agent and stabilizer, respectively...
August 12, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27280688/curcumin-a-new-candidate-for-melanoma-therapy
#6
REVIEW
Hamed Mirzaei, Gholamreza Naseri, Ramin Rezaee, Mohsen Mohammadi, Zarrin Banikazemi, Hamid Reza Mirzaei, Hossein Salehi, Mostafa Peyvandi, John M Pawelek, Amirhossein Sahebkar
Melanoma remains among the most lethal cancers and, in spite of great attempts that have been made to increase the life span of patients with metastatic disease, durable and complete remissions are rare. Plants and plant extracts have long been used to treat a variety of human conditions; however, in many cases, effective doses of herbal remedies are associated with serious adverse effects. Curcumin is a natural polyphenol that shows a variety of pharmacological activities including anti-cancer effects, and only minimal adverse effects have been reported for this phytochemical...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27221847/evaluation-of-anticancer-activity-of-curcumin-analogues-bearing-a-heterocyclic-nucleus
#7
Mohamed Jawed Ahsan, Mohamed Jawed Ahsan
We report herein an in vitro anticancer evaluation of a series of seven curcumin analogues (3a-g). The National Cancer Institute (NCI US) Protocol was followed and all the compounds were evaluated for their anticancer activity on nine different panels (leukemia, non small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer) represented by 60 NCI human cancer cell lines. All the compounds showed significant anticancer activity in one dose assay (drug concentration 10 μM) and hence were evaluated further in five dose assays (0...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27192978/protein-expression-changes-induced-in-a-malignant-melanoma-cell-line-by-the-curcumin-analogue-compound-d6
#8
Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri, Carla Rozzo
BACKGROUND: We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3'E)-4,4'-(5,5',6,6'-tetramethoxy-[1,1'-biphenyl]-3,3'-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a strong antitumor activity on melanoma cells both in vitro and in vivo. Although the mechanism of action of D6 is yet to be clarified, this compound is thought to inhibit cancer cell growth by arresting the cell cycle in G2/M phase, and to induce apoptosis through the mitochondrial intrinsic pathway...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27106025/c-jun-n-terminal-kinase-dependent-apoptotic-photocytotoxicity-of-solvent-exchange-prepared-curcumin-nanoparticles
#9
Verica Paunovic, Biljana Ristic, Zoran Markovic, Biljana Todorovic-Markovic, Milica Kosic, Jovana Prekodravac, Tamara Kravic-Stevovic, Tamara Martinovic, Matej Micusik, Zdeno Spitalsky, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Indian spice curcumin is known for its anticancer properties, but the anticancer mechanisms of nanoparticulate curcumin have not been completely elucidated. We here investigated the in vitro anticancer effect of blue light (470 nm, 1 W)-irradiated curcumin nanoparticles prepared by tetrahydrofuran/water solvent exchange, using U251 glioma, B16 melanoma, and H460 lung cancer cells as targets. The size of curcumin nanocrystals was approximately 250 nm, while photoexcitation induced their oxidation and partial agglomeration...
April 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27040234/curcumin-loaded-silica-based-mesoporous-materials-synthesis-characterization-and-cytotoxic-properties-against-cancer-cells
#10
Vishnu Sravan Bollu, Ayan Kumar Barui, Sujan Kumar Mondal, Sanjiv Prashar, Mariano Fajardo, David Briones, Antonio Rodríguez-Diéguez, Chitta Ranjan Patra, Santiago Gómez-Ruiz
Two different silica based (MSU-2 and MCM-41) curcumin loaded mesoporous materials V3 and V6 were synthesized and characterized by several physico-chemical techniques. Release kinetic study revealed the slow and sustained release of curcumin from those materials in blood simulated fluid (pH: 7.4). The materials V3 and V6 were found to be biocompatible in non-cancerous CHO cell line while exhibiting significant cytotoxicity in different cancer cells (human lung carcinoma cells: A549, human breast cancer cells: MCF-7, mouse melanoma cells: B16F10) compared to pristine curcumin indicating the efficacy of the mesoporous silica materials based drug delivery systems (DDSs)...
June 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27010501/evaluation-of-the-anti-inflammatory-action-of-curcumin-analog-dm1-effect-on-inos-and-cox-2-gene-expression-and-autophagy-pathways
#11
Niraldo Paulino, Amarilis Scremin Paulino, Susana N Diniz, Sergio de Mendonça, Ivair D Gonçalves, Fernanda Faião Flores, Reginaldo Pereira Santos, Carina Rodrigues, Paulo Celso Pardi, José Agustin Quincoces Suarez
This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.
April 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/26864554/phytochemicals-for-the-management-of-melanoma
#12
REVIEW
Harish Chandra Pal, Katherine Marchiony Hunt, Ariana Diamond, Craig A Elmets, Farrukh Afaq
Melanoma claims approximately 80% of skin cancer-related deaths. Its life-threatening nature is primarily due to a propensity to metastasize. The prognosis for melanoma patients with distal metastasis is bleak, with median survival of six months even with the latest available treatments. The most commonly mutated oncogenes in melanoma are BRAF and NRAS accounting approximately 60% and 20% of cases, respectively. In malignant melanoma, accumulating evidence suggests that multiple signaling pathways are constitutively activated and play an important role in cell proliferation, cell survival, epithelial to mesenchymal transition, metastasis and resistance to therapeutic regimens...
2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/26748069/prospective-of-curcumin-a-pleiotropic-signalling-molecule-from-curcuma-longa-in-the-treatment-of-glioblastoma
#13
REVIEW
Pratibha Mehta Luthra, Neetika Lal
GBM (Glioblastoma) is the most malignant human brain tumor with median survival of one year. The treatment involves surgery, radiotherapy and adjuvant chemotherapy mostly with the alkylation agents such as temozolomide (TMZ). Dietary polyphenol curcumin, isolated from the rhizome of the Curcuma longa (turmeric), has emerged as remarkable anti-cancer agent in the treatment of various peripheral cancers such as blood, lymphomas, multiple myeloma, melanoma as well as skin, lung, prostate, breast, ovarian, bladder, liver, gastrointestinal tract, pancreatic and colorectal epithelial cancers with a pleiotropic mode of action and also showed promise in alleviation of GBM...
February 15, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26597940/curcumin-delivery-by-poly-lactide-based-co-polymeric-micelles-an-in-vitro-anticancer-study
#14
Preeti Kumari, Muddineti Omkara Swami, Sravan Kumar Nadipalli, Srividya Myneni, Balaram Ghosh, Swati Biswas
PURPOSE: This work describes the synthesis of block co-polymeric micelles, methoxy-poly(ethylene glycol)-poly(D,L-lactide) (mPEG-PLA) to encapsulate Curcumin (CUR), thereby improving the dispersibility and chemical stability of curcumin, prolonging its cellular uptake and enhancing its bioavailability. METHODS: CUR-mPEG-PLA micelles, was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD)...
April 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/26537230/artepillin-c-and-other-herbal-pak1-blockers-effects-on-hair-cell-proliferation-and-related-pak1-dependent-biological-function-in-cell-culture
#15
Binh Cao Quan Nguyen, Nozomi Taira, Hiroshi Maruta, Shinkichi Tawata
PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic kinase, and a number of herbal PAK1-blockers such as propolis and curcumin have been shown to be anti-oncogenic and anti-melanogenic as well as anti-alopecia (promoting hair growth). Previously, we found several distinct PAK1-inhibitors in Okinawa plants including Alpinia zerumbet (alpinia). Thus, here, we tested the effects of these herbal compounds and their derivatives on the growth of cancer or normal hair cells, and melanogenesis in cell culture of A549 lung cancer, hair follicle dermal papilla cell, and B16F10 melanoma...
January 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26334519/curcumin-micelles-remodel-tumor-microenvironment-and-enhance-vaccine-activity-in-an-advanced-melanoma-model
#16
Yao Lu, Lei Miao, Yuhua Wang, Zhenghong Xu, Yi Zhao, Youqing Shen, Guangya Xiang, Leaf Huang
Previously, we have reported a lipid-based Trp2 peptide vaccine for immunotherapy against melanoma. The suppressive immune microenvironment in the tumor is a major hurdle for an effective vaccine therapy. We hypothesized that curcumin (CUR) would remodel the tumor microenvironment to improve the vaccine activity. Curcumin-polyethylene glycol conjugate (CUR-PEG), an amphiphilic CUR-based micelle, was delivered intravenously (i.v.) to the tumor. Indeed, in the B16F10 tumor-bearing mice, the combination of CUR-PEG and vaccine treatment resulted in a synergistic antitumor effect (P < 0...
February 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/26307827/development-of-rgd-functionalized-peg-pla-micelles-for-delivery-of-curcumin
#17
Liyan Zhao, Chunfen Yang, Jinfeng Dou, Yanwei Xi, Hongxiang Lou, Guangxi Zhai
Curcumin (Cur), a hydrophobic polyphenolic compound, possesses a wide range of biological activities. However, its prominent application in cancer treatment is limited due to low aqueous solubility and rapid metabolism. Recently, micelle-based drug delivery system has been proven to be an attractive alternative for poorly soluble drugs. In order to improve the application of Cur as an anti-cancer agent, in this study, we synthesized the αvβ3 integrin-targeted peptide (RGD) functionalized polymer (RGD-PEG-PLA)...
March 2015: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/26305550/curcumin-combined-with-fap%C3%AE-c-vaccine-elicits-effective-antitumor-response-by-targeting-indolamine-2-3-dioxygenase-and-inhibiting-emt-induced-by-tnf-%C3%AE-in-melanoma
#18
Guan-Min Jiang, Wan-Ying Xie, Hong-Sheng Wang, Jun Du, Bai-Ping Wu, Wei Xu, Hui-Fang Liu, Ping Xiao, Zhi-Gang Liu, Hong-Yan Li, Shuang-Quan Liu, Wen-Jun Yin, Qiu-Gui Zhang, Jian-Ping Liang, Hong-Jun Huang
Fibroblast activation protein α (FAPα) is a potential target for cancer therapy. However, elimination of FAPα+ fibroblasts activates secretion of IFN-γ and TNF-α. IFN-γ can in turn induce expression indolamine-2,3-dioxygenase (IDO), thereby contributing to immunosuppression, while TNF-α can induce EMT. These two reactive effects would limit the efficacy of a tumor vaccine. We found that curcumin can inhibit IDO expression and TNF-α-induced EMT. Moreover, FAPαc vaccine and CpG combined with curcumin lavage inhibited tumor growth and prolonged the survival of mice implanted with melanoma cells...
September 22, 2015: Oncotarget
https://www.readbyqxmd.com/read/26116776/abt-737-sensitizes-curcumin-induced-anti-melanoma-cell-activity-through-facilitating-mptp-death-pathway
#19
Teng Yu, Chao Chen, Yang Sun, Hui Sun, Tian-Hang Li, Jin Meng, Xianhua Shi
In the current study, we studied the potential role of ABT-737, a novel Bcl-2 inhibitor, on curcumin-induced anti-melanoma cell activity in vitro. The associated mechanisms were also investigated. We demonstrated that ABT-737 significantly sensitized curcumin-induced activity against melanoma cells (WM-115 and B16 lines), resulting in substantial cell death and apoptosis with co-administration. At the molecular level, curcumin and ABT-737 synergistically induced mitochondrial permeability transition pore (mPTP) opening in melanoma cells, the latter was evidenced by mitochondrial membrane potential (MPP) reduction and mitochondrial complexation between cyclophilin-D (CyPD) and adenine nucleotide translocator 1 (ANT-1)...
August 14, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26085173/orally-administered-chitosan-coated-polycaprolactone-nanoparticles-containing-curcumin-attenuate-metastatic-melanoma-in-the-lungs
#20
Gecioni Loch-Neckel, Lorena Santos-Bubniak, Letícia Mazzarino, Amanda V Jacques, Bárbara Moccelin, Maria Claúdia Santos-Silva, Elenara Lemos-Senna
The study was aimed to evaluate the effect of orally administered chitosan-coated nanoparticles containing curcumin on metastatic melanoma. Chitosan-coated nanoparticles containing curcumin were prepared, and their antimetastatic activity was investigated both in vitro and in vivo. Curcumin decreased cell viability and induced apoptosis of B16F10 melanoma cells. We observed that curcumin significantly decreased the expression of metalloproteinases, which are known to be associated with migration and proliferation of cancer cells...
October 2015: Journal of Pharmaceutical Sciences
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