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https://www.readbyqxmd.com/read/28544309/increased-complications-of-chronic-erythrocytapheresis-compared-with-manual-exchange-transfusions-in-children-and-adolescents-with-sickle-cell-disease
#1
Deborah Woods, Robert J Hayashi, Michael M Binkley, Gianna W Sparks, Monica L Hulbert
BACKGROUND: Children and adolescents with sickle cell disease (SCD) are at high risk of strokes and are frequently treated with red blood cell (RBC) transfusions. The goal is to suppress hemoglobin (Hb) S while minimizing transfusion-induced iron overload. RBCs may be given via simple transfusion, manual exchange transfusion (MET), or erythrocytapheresis (aRBCX). Chronic transfusion practices vary among institutions. METHODS: This single-institution, retrospective cohort study compares Hb S control and therapy complication rates between MET and aRBCX in a cohort of children and adolescents with SCD and stroke during a 5-year period from 2008 through 2012...
May 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28543812/acetylacetonatebodipy-biscyclometalated-iridium-iii-complexes-effective-strategy-towards-smarter-fluorescent-photosensitizer-agents
#2
Maria J Ortiz, Eduardo Palao, Rebeca Sola-Llano, Andrea Tabero, Hegoi Manzano, Antonia R Agarrabeitia, Angeles Villanueva, Iñigo López-Arbeloa, Virginia Martinez-Martinez
Biscyclometalated Ir(III) complexes involving BODIPY-based ancillary ligands, where the BODIPY unit is grafted to different chelating cores (acetylacetonate for Ir-1 and Ir-2, and bipyridine for Ir-3) by the BODIPY meso position, have been synthesized and characterized. Complexes having the BODIPY moiety directly grafted to acetylacetonate (Ir-1 and Ir-2) exhibit higher absorption coefficient (ca. ε = 4.46 104 M-1 cm-1 and 3.38 104 M-1cm-1 at 517 nm and 594 nm, respectively), higher moderate-fluorescence emission (ca...
May 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28540737/investigational-drugs-in-phase-i-and-phase-ii-clinical-trials-for-thalassemia
#3
Irene Motta, Natalia Scaramellini, Maria Domenica Cappellini
Regular transfusion and iron chelation are the current treatment of severe forms of thalassemia. As a result of this demanding supportive treatment, there are several unmet therapeutic needs. Due to a deeper understanding in the pathophysiology of thalassemia, new therapeutic strategies have been developed that are now in pre-clinical and clinical trials. Areas covered: Activin receptor ligand traps (luspatercept and sotatercept), drugs targeting ineffective erythropoiesis, showed encouraging results in Phase I and II clinical trials...
May 25, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28538871/what-do-cochrane-systematic-reviews-say-about-interventions-for-autism-spectrum-disorders
#4
Larissa Lyra, Luiz Eduardo Rizzo, Camila Sá Sunahara, Daniela Vianna Pachito, Carolina de Oliveira Cruz Latorraca, Ana Luiza Cabrera Martimbianco, Rachel Riera
CONTEXT AND OBJECTIVE: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was to summarize the evidence from Cochrane systematic reviews on interventions for ASDs. DESIGN AND SETTING: Review of systematic reviews, conducted within the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28535516/citrate-anticoagulation-during-continuous-renal-replacement-therapy
#5
Davide Ricci, Laura Panicali, Maria Grazia Facchini, Elena Mancini
During extracorporeal dialysis, some anticoagulation strategy is necessary to prevent the coagulation of blood. Heparin has historically been used as an anticoagulant because of its efficacy combined with low cost. However, a variable incidence of hemorrhagic complications (5-30%) has been documented in patients undergoing continuous renal replacement therapy (CRRT) with heparin as an anticoagulant. Citrate has anticoagulation properties secondary to its ability to chelate calcium, which is necessary for the coagulation cascade...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28533164/a-novel-iron-ii-preferring-dopamine-agonist-chelator-d-607-significantly-suppresses-%C3%AE-syn-and-mptp-induced-toxicities-in-vivo
#6
Banibrata Das, Subramanian Rajagopalan, Gnanada S Joshi, Liping Xu, Dan Luo, Julie K Andersen, Sokol V Todi, Aloke K Dutta
Here, we report the characterization of a novel hybrid D2/D3 agonist and iron (II) specific chelator, D-607, as a multi-target-directed ligand against Parkinson's disease (PD). In our previously published report, we showed that D-607 is a potent agonist of dopamine (DA) D2/D3 receptors, exhibits efficacy in a reserpinized PD animal model and preferentially chelates to iron (II). As further evidence of its potential as a neuroprotective agent in PD, the present study reveals D-607 to be protective in neuronal PC12 cells against 6-OHDA toxicity...
May 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28532285/utility-of-transient-elastography-in-estimating-hepatic-iron-concentration-in-comparison-to-magnetic-resonance-imaging-in-patients-who-are-transfusion-dependent-a-canadian-center-experience
#7
George Ou, Hin Hin Ko, Pari Tiwari, Navdeep Sandhu, Cherry Galorport, Terry Lee, Hatoon Ezzat
Transfusion-dependent hereditary anemias such as β-thalassemia (β-thal), predispose patients to iron overload and its numerous clinical sequelae. Accurate assessment of overall iron status and prompt initiation of chelation therapy to prevent irreversible end-organ damage can be achieved using magnetic resonance imaging (MRI) to measure liver iron concentration (LIC) as a surrogate marker of total body iron; however, its access may be associated with long wait times and delay in treatment. We report an observational cohort study at a single tertiary care center assessing the theoretical role of transient elastography (TE), which measures liver stiffness, in estimating LIC compared to other established diagnostic measures...
January 2017: Hemoglobin
https://www.readbyqxmd.com/read/28524118/novel-radiolabeled-bisphosphonates-for-pet-diagnosis-and-endoradiotherapy-of-bone-metastases
#8
REVIEW
Nina Pfannkuchen, Marian Meckel, Ralf Bergmann, Michael Bachmann, Chandrasekhar Bal, Mike Sathekge, Wolfgang Mohnike, Richard P Baum, Frank Rösch
Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are characterized by an increased bone turnover, which can be visualized by positron emission tomography (PET), as well as single-photon emission computed tomography (SPECT). Bisphosphonate complexes of (99m)Tc are predominantly used as SPECT tracers. In contrast to SPECT, PET offers a higher spatial resolution and, owing to the (68)Ge/(68)Ga generator, an analog to the established (99m)Tc generator exists. Complexation of Ga(III) requires the use of chelators...
May 18, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28521118/automated-cassette-based-production-of-high-specific-activity-203-212-pb-peptide-based-theranostic-radiopharmaceuticals-for-image-guided-radionuclide-therapy-for-cancer
#9
Mengshi Li, Xiuli Zhang, Thomas P Quinn, Dongyoul Lee, Dijie Liu, Falk Kunkel, Brian E Zimmerman, Daniel McAlister, Keith Olewein, Yusuf Menda, Saed Mirzadeh, Roy Copping, Frances L Johnson, Michael K Schultz
A method for preparation of Pb-212 and Pb-203 labeled chelator-modified peptide-based radiopharmaceuticals for cancer imaging and radionuclide therapy has been developed and adapted for automated clinical production. Pre-concentration and isolation of radioactive Pb2+ from interfering metals in dilute hydrochloric acid was optimized using a commercially-available Pb-specific chromatography resin packed in disposable plastic columns. The pre-concentrated radioactive Pb2+ is eluted in NaOAc buffer directly to the reaction vessel containing chelator-modified peptides...
May 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28515762/biochemical-and-histopathological-effects-of-green-tea-nanoparticles-in-ironized-mouse-model
#10
Hidayat Sulistyo, Dhadhang Wahyu Kurniawan, Lantip Rujito
Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28505405/structural-basis-for-xenosiderophore-utilization-by-the-human-pathogen-staphylococcus-aureus
#11
Nathaniel P Endicott, Eries Lee, Timothy Adam Wencewicz
Staphylococcus aureus produces a cocktail of metallophores (staphylopine, staphyloferrin A, and staphyloferrin B) to scavenge transition metals during infection of a host. In addition, S. aureus displays the extracellular surface lipoproteins FhuD1 and FhuD2 along with the ABC transporter complex FhuCBG to facilitate the use of hydroxamate xenosiderophores such as desferrioxamine B (DFOB) for iron acquisition. DFOB is used as a chelation therapy to treat human iron overload diseases and has been linked to an increased risk of S...
May 15, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28500860/interventions-for-preventing-silent-cerebral-infarcts-in-people-with-sickle-cell-disease
#12
REVIEW
Lise J Estcourt, Patricia M Fortin, Sally Hopewell, Marialena Trivella, Carolyn Doree, Miguel R Abboud
BACKGROUND: Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Silent cerebral infarcts are the commonest neurological complication in children and probably adults with SCD. Silent cerebral infarcts also affect academic performance, increase cognitive deficits and may lower intelligence quotient...
May 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28499214/speciation-of-potential-anti-diabetic-vanadium-complexes-in-real-serum-samples
#13
Daniele Sanna, Valeria Ugone, Maria Serra, Eugenio Garribba
In this work the speciation in real serum samples of five V(IV)O complexes with potential application in the therapy of diabetes was studied through EPR spectroscopy as a function of V concentration (45.4, 90.9 and 454.5μM) and time (0-180min). [VO(dhp)2], [VO(ma)2], [VO(acac)2], [VO(pic)2(H2O)], and [VO(mepic)2], where Hdhp indicates 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, Hma maltol, Hacac acetylacetone, Hpic picolinic acid, and Hmepic 6-methylpicolinic acid, were examined. The distribution of V(IV)O(2+) among the serum bioligands was calculated from the thermodynamic stability constants in the literature and compared with the experimental results...
April 25, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28485623/inhibition-of-amyloid-oligomerization-into-different-supramolecular-architectures-by-small-molecules-mechanistic-insights-and-design-rules
#14
Sayanti Brahmachari, Ashim Paul, Daniel Segal, Ehud Gazit
Protein misfolding and aggregation have been associated with several human disorders, including Alzheimer's, Parkinson's and Huntington's diseases, as well as senile systemic amyloidosis and Type II diabetes. However, there is no current disease-modifying therapy available for the treatment of these disorders. In spite of extensive academic, pharmaceutical, medicinal and clinical research, a complete mechanistic model for this family of diseases is still lacking. In this review, we primarily discuss the different types of small molecular entities which have been used for the inhibition of the aggregation process of different amyloidogenic proteins under diseased conditions...
May 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28482720/erythroid-response-during-iron-chelation-therapy-in-a-cohort-of-patients-affected-by-hematologic-malignancies-and-aplastic-anemia-with-transfusion-requirement-and-iron-overload-a-fism-italian-multicenter-retrospective-study
#15
Emanuela Messa, Lucia Biale, Anna Castiglione, Monia Lunghi, Margherita Bonferroni, Flavia Salvi, Bernardino Allione, Dario Ferrero, Chiara Calabrese, Marco De Gobbi, Paolo Nicoli, Daniela Gioia, Alessandro Levis, Giuseppe Saglio, Daniela Cilloni
No abstract text is available yet for this article.
May 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28472722/investigation-of-the-antimicrobial-effect-of-natural-deep-eutectic-solvents-nades-as-solvents-in-antimicrobial-photodynamic-therapy
#16
Kristine Opsvik Wikene, Håkon Valen Rukke, Ellen Bruzell, Hanne Hjorth Tønnesen
Natural deep eutectic solvents (NADES) are a third class of liquids, separate from water and lipids. Some NADES, especially those containing organic acids, have been suggested to possess antimicrobial properties. Such properties may be advantageous when NADES are used as solvents in e.g. antimicrobial photodynamic therapy. However, to control the toxicity of acid-containing NADES, they must retain their specific qualities upon dilution. Hence, the aims of this study were to investigate the effect of dilution on the acid-containing NADES network, their antimicrobial activity on different planktonic microorganisms, and their influence on phototoxicity when used as solvents for a photosensitiser...
April 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28471307/complications-pattern-and-burden-of-the-disease-in-patients-affected-by-beta-thalassaemia-major
#17
Fedele Bonifazi, Rosa Conte, Paola Baiardi, Donato Bonifazi, Mariagrazia Felisi, Paola Giordano, Viviana Giannuzzi, Angela Iacono, Rosa Padula, Alessia Pepe, Maria Caterina Putti, Lucia Ruggieri, Giovanni Carlo Del Vecchio, Aldo Filosa, Aurelio Maggio, Adriana Ceci
OBJECTIVES: Despite the correct application of blood transfusions and chelation treatments, beta-thalassaemia patients have many complications. Systematic population analyses on types and frequency of these complications are very few. The aim of this study is to characterize the complications,their risk factors and their clinical and economic impact. METHODS: Complications at baseline and events occurred during 1 observational year were analysed in 272 patients aged >12 years...
May 4, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28470934/lanthanide-complexes-in-molecular-magnetic-resonance-imaging-and-theranostics
#18
Eva Toth, Sara Lacerda
Lanthanide complexes have attracted continuous attention in the biomedical field and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insights into the mechanistic aspects that allow modulating the relaxation or chemical exchange saturation transfer (CEST) features, thus the MRI efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker...
May 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28469157/brain-iron-chelation-by-deferiprone-in-a-phase-2-randomised-double-blinded-placebo-controlled-clinical-trial-in-parkinson-s-disease
#19
Antonio Martin-Bastida, Roberta J Ward, Rexford Newbould, Paola Piccini, David Sharp, Christina Kabba, Maneesh C Patel, Michael Spino, John Connelly, Fernando Tricta, Robert R Crichton, David T Dexter
Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra (SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to chelate iron from various brain regions and improve PD symptomology. In a randomised double-blind, placebo controlled trial, 22 early onset PD patients, were administered deferiprone, 10 or 15 mg/kg BID or placebo, for 6 months. Patients were evaluated for PD severity, cognitive function, depression rating and quality of life...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28467346/chronic-anemia-and-thyroid-function
#20
Ashraf T Soliman, Vincenzo De Sanctis, Mohamed Yassin, Magda Wagdy, Nada Soliman
Anaemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. Iron deficiency anaemia (IDA) impairs thyroid metabolism in animals and human and may negatively affect growth and develpment of children. On the other hand both overt and subclinical hypothyroidism are associated with anemia and adding iron to thyroxine therapy improves both conditions compared to thyroxine therapy alone...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
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