Elena K Enax-Krumova, Iris Dahlhaus, Jonas Görlach, Kristl G Claeys, Federica Montagnese, Llka Schneider, Dietrich Sturm, Tanja Fangerau, Hannah Schlierbach, Angela Roth, Julia V Wanschitz, Wolfgang N Löscher, Anne-Katrin Güttsches, Stefan Vielhaber, Rebecca Hasseli, Lea Zunk, Heidrun H Krämer, Andreas Hahn, Benedikt Schoser, Angela Rosenbohm, Anne Schänzer
BACKGROUND: Pain occurs in the majority of patients with late onset Pompe disease (LOPD) and is associated with a reduced quality of life. The aim of this study was to analyse the pain characteristics and its relation to a small nerve fiber involvement in LOPD patients. METHODS: In 35 patients with LOPD under enzyme replacement therapy without clinical signs of polyneuropathy (19 females; 51 ± 15 years), pain characteristics as well as depressive and anxiety symptoms were assessed using the PainDetect questionnaire (PDQ) and the hospital anxiety and depression scale (HADS), respectively...
April 27, 2022: Orphanet Journal of Rare Diseases