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https://www.readbyqxmd.com/read/28538561/is-rotation-a-concern-with-anatomical-breast-implants-a-statistical-analysis-of-factors-predisposing-to-rotation
#1
Paolo Montemurro, Athanasios Papas, Per Hedén
BACKGROUND: Since their introduction in 1993, anatomical implants have provided a more natural appearance in breast augmentation, and many surgeons advocate their use and promote the good aesthetic results. However, the risk of implant rotation makes some of them reluctant to use these devices. The rotation rate varies among authors. METHODS: The authors present a 6.5-year series of 531 patients who underwent primary breast augmentation with macrotextured anatomical implants in a Swedish facility performed by one consultant surgeon (P...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538550/breast-cancer-after-augmentation-oncologic-and-reconstructive-considerations-among-women-undergoing-mastectomy
#2
Eugenia H Cho, Ronnie L Shammas, Brett T Phillips, Rachel A Greenup, E Shelley Hwang, Scott T Hollenbeck
BACKGROUND: Breast augmentation with subglandular versus subpectoral implants may differentially impact the early detection of breast cancer and treatment recommendations. The authors assessed the impact of prior augmentation on the diagnosis and management of breast cancer in women undergoing mastectomy. METHODS: Breast cancer diagnosis and management were retrospectively analyzed in all women with prior augmentation undergoing therapeutic mastectomy at the authors' institution from 1993 to 2014...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28534994/amplification-and-the-clinical-significance-of-circulating-cell-free-dna-of-pvt1-in-breast-cancer
#3
Xujing Li, Weijuan Chen, Hui Wang, Qun Wei, Xiaodi Ding, Wentong Li
Duplication in the chromosome 8q24 region is a frequent occurrence in carcinomas. The PVT1 oncogene (PVT1), a long non-coding RNA, is found in this locus. PVT1 amplification is a frequent event in cancers, such as in lymphomas, serous ovarian, colorectal and breast cancers. Ectopic PVT1 expression is related with reduced survival duration in cancer patients. in the present study, we proved that PVT1 is markedly augmented in breast cancer tissues compared with adjacent non-tumorous tissues. Thus, PVT1 is an independent prognostic factor for the survival duration of breast cancer patients...
May 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28521432/interleukin-17-augments-tumor-necrosis-factor-%C3%AE-mediated-increase-of-hypoxia-inducible-factor-1%C3%AE-and-inhibits-vasodilator-stimulated-phosphoprotein-expression-to-reduce-the-adhesion-of-breast-cancer-cells
#4
Kuang Changchun, Hu Pengchao, Su Ke, Wang Ying, Wei Lei
Interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α are able to cooperatively alter the expression levels of a number of genes. In the present study, the mRNA expression levels of hypoxia-inducible factor (HIF)-1α were analyzed in MDA-MB-231 breast cancer cells following treatment with IL-17, TNF-α or the combination of IL-17 and TNF-α. The protein expression levels of HIF-1α and vasodilator-stimulated phosphoprotein (VASP) were evaluated using western blot analysis. The adhesive ability of the cells was determined using an MTT assay following treatment with HIF-1α-small interfering RNA and short hairpin RNA-VASP that were used to suppress the expression levels of HIF-1α and VASP protein, respectively...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28514124/-partial-breast-reconstruction-by-modified-breast-reduction-techniques
#5
REVIEW
Dean D Ad-El, Sagit Meshulam Derazon, Eran Sharon, Asaf Olshinka
Partial resections of the breast are more than 50% of breast oncological surgery. The resulting defect can be substantial and cause meaningful deformity that leads to reduced body image satisfaction of the patients, affecting their ability to cope with the cancer. Parallel to the development of breast oncology techniques, an evolution of breast reconstruction techniques occurred. During the last decade, by using techniques from cosmetic breast surgery (such as breast reductions, augmentations and mastopexies), we can reconstruct extensive partial defects of the breasts at the immediate and delayed setting and achieve symmetrical aesthetic results...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28510648/commentary-on-functional-and-volumetric-analysis-of-the-pectoralis-major-muscle-after-submuscular-breast-augmentation
#6
Per Hedén
No abstract text is available yet for this article.
June 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28508819/128-shades-of-red-objective-remote-assessment-of-radiation-dermatitis-by-augmented-digital-skin-imaging
#7
Richard Partl, Beata Jonko, Stefan Schnidar, Michael Schöllhammer, Max Bauer, Sanchit Singh, Julia Simeckova, Kathrin Wiesner, Andreas Neubauer, Harald Schnidar
The purpose of our investigation was to develop a novel and state of the art digital skin imaging method capable for remote monitoring and objective assessment of Radiation Induced Dermatitis (RID). Therefore, radiation therapy related side effects were assessed by medical experts according to Common Terminology Criteria for Adverse Events (CTCAE) grade of severity in 20 female breast cancer patients in a clinical trial over the treatment time frame of 25-28 radiation cycles, 50.0-50.4 Gy each. Furthermore the intensity of developed skin erythema was documented by using conventional spectrophotometry plus digital skin imaging...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506804/chloroquine-enhances-the-antimycobacterial-activity-of-isoniazid-and-pyrazinamide-by-reversing-inflammation-induced-macrophage-efflux
#8
U Matt, P Selchow, M Dal Molin, S Strommer, O Sharif, K Schilcher, F Andreoni, A Stenzinger, A S Zinkernagel, M Zeitlinger, P Sander, J Nemeth
Mycobacterium tuberculosis (MTB) is notorious for persisting within host macrophages. Efflux pumps decrease intracellular drug levels, thus fostering persistence of MTB during therapy. Isoniazid (INH) and pyrazinamide (PZA) are substrates of the efflux pump breast cancer resistance protein-1 (BCRP-1), which is inhibited by chloroquine (CQ). In this study, BCRP-1 was found to be expressed on macrophages of human origin and on foamy giant cells at the site of MTB infection. In the current in vitro study, interferon-gamma (IFNγ) increased the expression of BCRP-1 in macrophages derived from the human monocytic leukaemia cell line THP-1...
May 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28505536/design-synthesis-molecular-docking-and-cytotoxic-evaluation-of-novel-2-furybenzimidazoles-as-vegfr-2-inhibitors
#9
Mona A Abdullaziz, Heba T Abdel-Mohsen, Ahmed M El Kerdawy, Fatma A F Ragab, Mamdouh M Ali, Sherifa M Abu-Bakr, Adel S Girgis, Hoda I El Diwani
Inhibition of angiogenesis through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2) has been applied in cancer therapy because of its important role in promoting cancer growth and metastasis. In the presented study, a series of benzimidazol-furan hybrids was designed and synthesized through facile synthetic pathways. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against breast (MCF-7) and hepatocellular (HepG2) carcinoma cell lines was performed. Two of the synthesized conjugates, 10b and 15, showed potent antiproliferative properties against MCF-7 cell line (IC50 = 21...
April 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28499276/augmented-expression-of-polo-like-kinase-1-indicates-poor-clinical-outcome-for-breast-patients-a-systematic-review-and-meta-analysis
#10
REVIEW
Zhang Yunfeng, Wu Zhibin, Liu Dapeng, Wang Meng, Xiao Guodong, Wang Peili, Sun Xin, Ren Hong, Tang Shou-Ching, Du Ning
Polo-like kinases 1 (PLK1), a key regulator of mitosis, plays an essential role in maintaining genomic stability. Up-regulation of PLK1 was found in tumorigenesis and tumor progression of diverse cancers. However, the clinicopathological and prognostic implications of PLK1 in breast cancer (BC) have yet to be unveiled. Therefore, using PubMed, Web of Science, Embase, and Chinese databases, we conducted a meta-analysis to define the potential clinical value of PLK1 in BC. Eleven eligible articles with 2481 patients enrolled were included in the present meta-analysis, of which eight studies reported on the relationship between PLK1 expression and clinicopathological features, and nine studies provided survival data in BC patients...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28497025/how-to-prevent-complications-in-breast-augmentation
#11
REVIEW
Maurizio Bruno Nava, Alberto Rancati, Claudio Angrigiani, Giuseppe Catanuto, Nicola Rocco
No high-level evidences about the best technique or the best implant to use for obtaining the best outcomes in aesthetic breast augmentation, with low complications and re-interventions rates exist from available literature. In this paper we present the actual best evidence about the etiopathogenesis of main complications in aesthetic breast augmentation, identifying some basic rules to follow in order to reduce complication rates in our daily activity, minimizing re-interventions, obtaining long lasting results and high women's satisfaction levels...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497024/decisional-pathways-in-breast-augmentation-how-to-improve-outcomes-through-accurate-pre-operative-planning
#12
REVIEW
Maurizio B Nava, Nicola Rocco, Gianfranco Tunesi, Giuseppe Catanuto, Alberto Rancati, Julio Dorr
Breast augmentation is the most commonly performed surgical procedure in aesthetic plastic surgery. Accurate pre-operative planning is crucial to obtain the best outcomes. We present our planning method deriving from a more than 30-year experience in aesthetic breast surgery, matching together patients tissues' characteristics and patients' wishes. We schematized our planning method in an easy-to-use flow diagram to help the decisional process in breast augmentation.
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497023/the-waterfall-effect-in-breast-augmentation
#13
REVIEW
James Frame
The 'waterfall effect' is a descriptive term to indicate a sliding ptosis of parenchymal breast tissue over a fixed or encapsulated implant. It occurs more frequently than surgeons anticipate and especially over the longer term after augmentation. Certain breast implants are more prone to contribute to this problem as are implants placed in submuscular pockets that ride high, especially in women with anatomical musculoskeletal variance or asymmetry. This article describes the aetiology of sliding ptosis in more detail, the relevant anatomy and the surgical correction...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28497018/breast-implant-design
#14
REVIEW
G Patrick Maxwell, Allen Gabriel
Breast Augmentation remains as one of the most common procedures performed in the United States. This article explores the evolution of breast implants with special emphasis on the advancement of the silicone implants.
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28494752/mda-met-conditioned-medium-augments-the-chemoattractant-dependent-migration-of-mda-met-cells-towards-hfob-conditioned-medium-and-increases-collagenase-activity
#15
Karis Chin-Quee, Henry J Donahue
BACKGROUND: Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche. In this study, we used human fetal osteoblastic cells and MDA-MET, a metastatic and preferentially bone homing derivative of the breast cancer cell line MDA-MB-231. We examined 1) whether secreted factors from MDA-MET cells increase generation of chemoattractants by human foetal osteoblastic cells 2) whether MDA-MET cells were responsive to these chemoattractants and 3) the identity of these chemoattractants...
May 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28491314/major-depressive-disorder-with-religious-struggle-and-completed-suicide-after-hair-transplantation
#16
Mehmet Emin Ceylan, Barış Önen Ünsalver, Alper Evrensel
OBJECTIVES: Psychological outcomes of aesthetic surgical procedures like hair transplantation are mostly positive including decreased anxiety, depression and social phobia and increased general well-being, self-efficacy and self-esteem. However, some patients may suffer from post-surgical depression and post-surgical increased suicide rates have been reported for breast augmentation patients. Difficulty adapting to the new image, unfulfilled psychological needs expected to be met by the surgery, side effects of the surgery like tissue swelling or bruising, uncontrolled pain, presence of body dysmorphic disorder and previous history of mood disorder may be some of the risk factors for post-surgical depression...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28487507/transcriptional-regulation-of-foxp3-requires-integrated-activation-of-both-promoter-and-cns-regions-in-tumor-induced-cd8-treg-cells
#17
Sreeparna Chakraborty, Abir K Panda, Sayantan Bose, Dia Roy, Kirti Kajal, Deblina Guha, Gaurisankar Sa
T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. CD4(+) Treg cells are well characterized whereas the role of CD8(+) Tregs in cancer has recently started to crease attention. Here, we report an augmentation CD8(+)FOXP3(+) Tregs in breast tumor microenvironment. FOXP3, the lineage-specific transcription factor, is a dominant regulator of Treg cell development and function. FOXP3 is induced preferentially by divergent signaling in CD4(+) Treg cells. But how FOXP3 is induced and maintained in tumor-CD8(+) Tregs is the Cinderella of the investigation...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476310/intra-operative-techniques-to-reduce-the-risk-of-capsular-contracture-in-patients-undergoing-aesthetic-breast-augmentation-a-review
#18
REVIEW
J D Horsnell, A E Searle, P A Harris
BACKGROUND: Capsular contracture is a significant complication following aesthetic breast augmentation. Efforts to reduce this incidence have focused on the surgical approach, implant selection and IV antibiotics. Intra-operative methods to reduce the risk have had less investigation. This review focuses on these interventions and will document evidence to support pocket irrigation, nipple shields, drains and the use of an implant insertion funnel. METHODS: A comprehensive review of Pubmed, Scopus and Embase was performed to identify relevant papers published since 2000...
May 2, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28473665/anti-tumor-activity-of-an-immunotoxin-tgf%C3%AE-pe38-delivered-by-attenuated-salmonella-typhimurium
#19
Daejin Lim, Kwang Soo Kim, Hyunju Kim, Kyong-Cheol Ko, Jae Jun Song, Jong Hyun Choi, Minsang Shin, Jung-Joon Min, Jae-Ho Jeong, Hyon E Choy
The anticancer strategy underlying the use of immunotoxins is as follows: the cancer-binding domain delivers the toxin to a cancer cell, after which the toxin enters and kills the cell. TGFα-PE38 is an immunotoxin comprising transforming growth factor alpha (TGFα), a natural ligand of epidermal growth factor receptor (EGFR), and a modified Pseudomonas exotoxin A (PE38) lacking N terminal cell-binding domain, a highly potent cytotoxic protein moiety. Tumor cells with high level of EGFR undergo apoptosis upon treatment with TGFα-PE38...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28466788/vanadium-iii-l-cysteine-enhances-the-sensitivity-of-murine-breast-adenocarcinoma-cells-to-cyclophosphamide-by-promoting-apoptosis-and-blocking-angiogenesis
#20
Abhishek Basu, Arin Bhattacharjee, Rathindranath Baral, Jaydip Biswas, Amalesh Samanta, Sudin Bhattacharya
Various epidemiological and preclinical studies have already established the cancer chemopreventive potential of vanadium-based compounds. In addition to its preventive efficacy, studies have also indicated the abilities of vanadium-based compounds to induce cell death selectively toward malignant cells. Therefore, the objective of the present investigation is to improve the therapeutic efficacy and toxicity profile of an alkylating agent, cyclophosphamide, by the concurrent use of an organovanadium complex, vanadium(III)-l-cysteine...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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