Xiao Deng, Seyed Ehsan Saffari, Nan Liu, Bin Xiao, John Carson Allen, Samuel Yong Ern Ng, Nicole Chia, Yi Jayne Tan, Xinyi Choi, Dede Liana Heng, Yew-Long Lo, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Adeline Ng, Eng-King Tan, Louis C S Tan
The biological underpinnings of the PD clusters remain unknown as the existing PD clusters lacks biomarker characterization. We try to identify clinical subtypes of Parkinson Disease (PD) in an Asian cohort and characterize them by comparing clinical assessments, genetic status and blood biochemical markers. A total of 206 PD patients were included from a multi-centre Asian cohort. Hierarchical clustering was performed to generate PD subtypes. Clinical and biological characterization of the subtypes were performed by comparing clinical assessments, allelic distributions of Asian related PD gene (SNCA, LRRK2, Park16, ITPKB, SV2C) and blood biochemical markers...
August 29, 2022: NPJ Parkinson's Disease