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https://www.readbyqxmd.com/read/28929640/rho-kinase-inhibitor-fasudil-attenuates-contrast-induced-acute-kidney-injury
#1
Yiming Wang, Hao Zhang, Zhijian Yang, Dengshun Miao, Dingguo Zhang
In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (1) control group, (2) CI-AKI induced by contrast media (CM group), (3) CI-AKI plus low-dose fasudil (LD group) and (4) CI-AKI plus high-dose fasudil (HD group). Animals from groups 2-4 received iodixanol (4...
September 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28917177/formation-of-iodinated-thms-during-chlorination-of-water-and-wastewater-in-the-presence-of-different-iodine-sources
#2
Ioanna Pantelaki, Dimitra Voutsa
The formation potential of iodinated trihalomethanes (I-THMs) during chlorination of different organic precursors in the presence of various iodine sources was studied. Organic precursors included humic acid, natural organic matter from river water and wastewater effluent organic matter. Inorganic iodide and two iodinated X-ray contrast media compounds (iopamidol and diatrizoate) were used as iodine sources. The formation potential of I-THMs under different experimental conditions (chlorination contact time, iodide and bromide concentrations) was investigated...
September 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28912882/atorvastatin-alleviates-iodinated-contrast-media-induced-cytotoxicity-in-human-proximal-renal-tubular-epithelial-cells
#3
Gai-Ling Liu, Rong Lei, Shao-Bin Duan, Mi-Mi Tang, Min Luo, Qian Xu
Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28900045/gbcas-and-risk-for-nephrogenic-systemic-fibrosis-a-literature-review
#4
Asher Street Beam, Kristi G Moore, Savannah N Gillis, Kala F Ford, Tyler Gray, Anne Howard Steinwinder, Alexa Graham
PURPOSE: To examine the risks of using of gadolinium-based contrast agents (GBCAs) in magnetic resonance (MR) imaging and explore strategies to reduce the likeliness of adverse effects in patients who might be at risk for developing nephrogenic system fibrosis (NSF). METHODS: A search of 3 scholarly databases was performed to identify articles that discuss adverse reactions to GBCAs, specifically relating to kidney function, in MR examinations. A total of 20 peer-reviewed articles were analyzed...
July 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28894591/efficacy-of-oral-contrast-agents-for-upper-gastrointestinal-signal-suppression-in-mrcp-a-systematic-review-of-the-literature
#5
Anne Frisch, Thula C Walter, Bernd Hamm, Timm Denecke
BACKGROUND: Orally administered substances which suppress signals from gastrointestinal fluid can be used to enhance image quality in magnetic resonance cholangiopancreatography (MRCP). In daily practice, the available substances range from commercial products to regular viands such as fruit juices. PURPOSE: To provide an overview on the significance of and the substances used as gastrointestinal fluid signal suppressors in MRCP. MATERIAL AND METHODS: A systematic review of the existing literature was performed to evaluate the efficacy and efficiency of oral T2-signal suppressors in MRCP...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28882034/one-step-fast-synthesis-of-nanoparticles-for-mri-coating-chemistry-as-the-key-variable-determining-positive-or-negative-contrast
#6
Juan Pellico, Jesús Ruiz-Cabello, Irene Fernández-Barahona, Lucía Gutiérrez, Ana V Lechuga-Vieco, Jose A Enríquez, M Puerto Morales, Fernando Herranz
Iron oxide nanomaterial is a typical example of a magnetic resonance imaging probe for negative contrast. It has also been shown how this nanomaterial can be synthesized for positive contrast by modification of the composition and size of the core. However, the role of the organic coating in the relaxometric properties is largely unexplored. Here, maghemite nanoparticles with either excellent positive or very good negative contrast performance are obtained by modifying coating thickness while the core is kept unchanged...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28881643/critical-analysis-of-the-major-and-ancillary-imaging-features-of-li-rads-on-127-proven-hccs-evaluated-with-functional-and-morphological-mri-lights-and-shadows
#7
Vincenza Granata, Roberta Fusco, Antonio Avallone, Francesco Filice, Fabiana Tatangelo, Mauro Piccirillo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
PURPOSE: To report a critical analysis of major and ancillary MR imaging features in assessment of HCC. METHODS: Retrospectively we evaluated 70 cirrhotic patients with 173 nodules, which were subjected to MR study at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different contrast media. EOB-GD-DTPA was injected at MR0 and MR6, while Gd-BT-DO3A at MR3. Three expert hepatic radiologists reviewed all images, recording, according to LI-RADS, the size, the presence and quality of arterial-phase hyperenhancement, washout and capsule appearance, threshold growth...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876979/general-anaesthesia-for-patients-with-a-history-of-a-contrast-medium-induced-anaphylaxis-a-useful-prophylaxis
#8
Ingrid Boehm, Knud Nairz, John Morelli, Patricia Silva Hasembank Keller, Johannes Thomas Heverhagen
Contrast-enhanced radiological examinations are important diagnostic tools in modern medicine. Currently, all approved and available iodinated and gadolinium-based contrast agents are safe and well tolerated by most patients. However, approximately 2% of patients receiving iodinated contrast media (CM) exhibit hypersensitivity reactions. Patients with a history of such a reaction are at increased risk upon re-exposure. Therefore, they are subjected to a prophylaxis such as injection of anti-allergy drugs or general anesthesia...
September 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28874655/serum-neutrophil-gelatinase-associated-lipocalin-and-urinary-kidney-injury-molecule-1-as-potential-biomarkers-of-subclinical-nephrotoxicity-after-gadolinium-based-and-iodinated-based-contrast-media-exposure-in-pediatric-patients-with-normal-kidney-function
#9
Brankica Spasojević-Dimitrijeva, Jelena Kotur-Stevuljević, Milan Đukić, Dušan Paripović, Gordana Miloševski-Lomić, Vesna Spasojević-Kalimanovska, Polina Pavićević, Jadranka Mitrović, Mirjana Kostić
BACKGROUND New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function...
September 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28860894/high-pitch-coronary-ct-angiography-at-70-kvp-adopting-a-protocol-of-low-injection-speed-and-low-volume-of-contrast-medium
#10
Ruiqi Feng, Jiajie Tong, Xiaofei Liu, Yu Zhao, Liang Zhang
OBJECTIVE: To evaluate the feasibility and image quality (IQ) of prospectively high-pitch coronary CT angiography (CCTA) with low contrast medium injection rate at 70 kVp. MATERIALS AND METHODS: One hundred and four patients with suspected coronary artery disease (body mass index < 26 kg/m(2), sinus rhythm and heart rate < 70 beats/min) were prospectively enrolled and randomly divided into two groups. In group A and group B, 28 mL and 40 mL of 370 mgI/mL iodinated contrast media was administrated at a flow rate of 3...
September 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28857310/orotracheal-manganese-enhanced-mri-memri-an-effective-approach-for-lung-tumor-detection
#11
Andrea Bianchi, Oliviero L Gobbo, Sandrine Dufort, Lucie Sancey, François Lux, Olivier Tillement, Jean-Luc Coll, Yannick Crémillieux
Lung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time (UTE) MRI sequences, in combination with gadolinium-based contrast agents, have indeed shown to be especially adapted to the detection of lung neoplastic lesions at submillimeter precision. Manganese-enhanced MRI (MEMRI) increasingly appears to be a possible effective alternative to gadolinium-enhanced MRI...
August 31, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28856499/correlation-between-arterial-spin-labeling-perfusion-and-histopathological-vascular-density-of-pediatric-intracranial-tumors
#12
Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Koji Yoshimoto, Masahiro Mizoguchi, Satoshi O Suzuki, Toru Iwaki, Yuriko Suzuki, Hiroshi Honda
Traditional MRI methods for estimation of blood flow in brain tumors require high-flow injection of contrast agents through large-bore intravenous access, which limits their pediatric utility. In contrast, arterial spin-labeling (ASL) can be used without contrast media. This study aimed to evaluate the relationship between tumor blood flow (TBF) measured by ASL and histopathological vascular density in pediatric brain tumors. Nineteen consecutive children were evaluated (10 boys, 9 girls; median age: 6 years; 8 high-grade and 11 low-grade tumors)...
August 30, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28856420/iodine-based-contrast-media-multiple-myeloma-and-monoclonal-gammopathies-literature-review-and-esur-contrast-media-safety-committee-guidelines
#13
Fulvio Stacul, Michele Bertolotto, Henrik S Thomsen, Gabriele Pozzato, Donatella Ugolini, Marie-France Bellin, Georg Bongartz, Olivier Clement, Gertraud Heinz-Peer, Aart van der Molen, Peter Reimer, Judith A W Webb
OBJECTIVES: Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patients. METHODS: A systematic search in Medline and Scopus databases was performed for renal function deterioration studies in patients with MM or MG following administration of iodine-based contrast media...
August 30, 2017: European Radiology
https://www.readbyqxmd.com/read/28845938/-questions-of-terminology-systematization-and-grading-of-complications-of-contact-ureteral-lithotripsy
#14
V V Dutov, V V Bazaev, E A Mamedov, S B Urenkov, A A Podoinitsyn
AIM: To investigate the advantages and disadvantages of the current variants of systematization and grading of complications of contact ureteral lithotripsy (CULT) and develop a working classification of CULT complications. MATERIALS AND METHODS: The study analyzed results of 545 fluoroscopy-guided endoscopic procedures performed at the MRRCI Clinic of Urology from 2008 to 2015 in 506 patients with ureterolithiasis. RESULTS: The proposed and implemented classification and terminology of CULT complications unifies the diagnostic and management algorithm...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28844518/usefulness-of-sodium-bicarbonate-for-the-prevention-of-contrast-induced-nephropathy-in-patients-undergoing-cardiac-resynchronization-therapy
#15
Pau Alonso, Jorge Sanz, Ana García-Orts, Samuel Reina, Sonia Jiménez, Joaquín Osca, Oscar Cano, Ana Andrés, María José Sancho-Tello, Luis Martínez
The use of contrast media during cardiac resynchronization therapy (CRT) devices implantation is associated with the risk of contrast-induced nephropathy (CIN). The aim of this study was to evaluate the possible beneficial role of periprocedural intravenous volume expansion with isotonic saline and sodium bicarbonate solution in patients who undergo CRT implantation. Eligible patients were randomly assigned in a 1:1 ratio to receive hydration plus one-sixth molar sodium bicarbonate (study group) or not (control group)...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28842112/rcr-audit-of-compliance-with-uk-guidelines-for-the-prevention-and-detection-of-acute-kidney-injury-in-adult-patients-undergoing-iodinated-contrast-media-injections-for-ct
#16
L H Cope, K J Drinkwater, D C Howlett
AIM: To determine radiology departmental compliance with current UK guidance on contrast-induced acute kidney injury (CI-AKI) and to provide data on the incidence of clinically significant post-contrast AKI (PC-AKI) in computed tomography (CT) practice. MATERIALS AND METHODS: A questionnaire was sent to all UK acute National Health Service (NHS) providers (NHS boards in Scotland, local health boards in Wales, NHS trusts in England and health and social care trusts in Northern Ireland) to assess compliance of provider protocols with current UK guidelines for the prevention, recognition, and management of CI-AKI...
August 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28830201/enhanced-radiation-dose-and-dna-damage-associated-with-iodinated-contrast-media-in-diagnostic-x-ray-imaging
#17
Richard W Harbron, Elizabeth A Ainsbury, Simon D Bouffler, Rick J Tanner, Jonathan S Eakins, Mark S Pearce
A review was undertaken of studies reporting increased DNA damage in circulating blood cells and increased organ doses, for x-ray exposures enhanced by iodinated contrast media (ICM), compared to unenhanced imaging. This effect may be due to ICM molecules acting as a source of secondary radiation (Auger/photoelectrons, fluorescence x-rays) following absorption of primary x-ray photons.It is unclear if the reported increase in DNA damage to blood cells necessarily implies an increasedrisk of developing cancer...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28827844/post-mortem-computed-tomography-angiography-using-left-ventricle-cardiac-puncture-a-whole-body-angiographic-approach
#18
Yu Shao, Lei Wan, Jianhua Zhang, Zhengdong Li, Ningguo Liu, Ping Huang, Donghua Zou, Yijiu Chen
Post-mortem computed tomography (PMCT) and PMCT angiography (PMCTA) are rapidly becoming effective and practical methods in forensic medicine. In this article, the authors introduce a whole-body PMCTA approach involving left ventricle cardiac puncture. This procedure was performed in 9 males and 3 females. PMCT was performed first. Then a biopsy core needle was used for a percutaneous puncture into the left ventricle through the intercostal area under CT guidance. 1000 mL of contrast media (diatrizoate meglumine and normal saline [0...
2017: PloS One
https://www.readbyqxmd.com/read/28825888/ten-things-you-might-not-know-about-iron-oxide-nanoparticles
#19
REVIEW
Heike E Daldrup-Link
Amid mounting concerns about nephrogenic sclerosis and gadolinium deposition in the brain, physicians and patients alike are starting to question the use of gadolinium chelates for clinical magnetic resonance (MR) imaging. The search for safer alternatives is currently underway. In North America, the iron supplement ferumoxytol has gained considerable interest as an MR contrast agent. In Europe, ferumoxtran-10 is entering phase III clinical trials. As these agents are starting to be used by a new generation of radiologists, important clinical questions have re-emerged, including those that have been answered in the past...
September 2017: Radiology
https://www.readbyqxmd.com/read/28815859/performance-of-mri-for-suspected-appendicitis-in-pediatric-patients-and-negative-appendectomy-rate-a-systematic-review-and-meta-analysis
#20
Jeong Rye Kim, Chong Hyun Suh, Hee Mang Yoon, Ah Young Jung, Jin Seong Lee, Jung Heon Kim, Jeong-Yong Lee, Young Ah Cho
PURPOSE: To evaluate in pediatric patients the diagnostic performance of magnetic resonance imaging (MRI) for suspected appendicitis and its negative appendectomy rate. MATERIALS AND METHODS: The study involved diagnostic accuracy studies that used MRI for pediatric patients with suspected appendicitis. Various field strengths and sequences were used in each included study. The diagnostic accuracy of MRI in pediatric patients with suspected appendicitis and negative appendectomy rate were assessed...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
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