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Cancer and radioresistance

Li Shen, Qing Ke, Jingjing Chai, Chuanyi Zhang, Li Qiu, Feng Peng, Xinzhou Deng, Zhiguo Luo
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) is a ubiquitous protein that is essential for the development and progression of various malignancies. A previous study in our laboratory confirmed that PAG1 plays an important role in modulating the inherent radioresistance of laryngeal cancer cells, but the underlying mechanisms are still poorly defined. In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissues (P < 0...
June 15, 2018: Experimental Cell Research
Yan Zhou, Ping He, Xuhua Xie, Changyu Sun
Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with high recurrence and metastasis rates. Radiotherapy represents a major therapeutic option for HCC patients. However, the efficacy of radiotherapy has been limited due to the development of intrinsic radioresistance of the tumor cells. Small ubiquitin-like modifier 1 pseudogene 3 (SUMO1P3), one member of SUMO pseudogene family, is a novel identified lncRNA that was originally identified to be upregulated in gastric cancer...
June 15, 2018: Molecular and Cellular Biochemistry
June Lee, Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo, Young-Sam Keum
NF-E2-related factor 2 (NRF2) regulates transcription of phase II cytoprotective enzymes to protect normal cells against oxidative stress. However, a high level of NRF2 offers a growth advantage, chemoresistance, and radioresistance in cancer. In the present study, we have identified convallatoxin as a novel inhibitor of NRF2/ARE suppression of NRF2 by convallatoxin was not transcriptionally mediated, but regulated at the level of proteolysis. Convallatoxin activated GSK-3β and suppression of NRF2 by convallatoxin required the Neh6 domain...
June 14, 2018: Free Radical Research
Ha S Nguyen, Saman Shabani, Ahmed J Awad, Mayank Kaushal, Ninh Doan
Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. With its overall dismal prognosis (the median survival is 14 months), GBMs demonstrate a resounding resilience against all current treatment modalities. The absence of a major progress in the treatment of GBM maybe a result of our poor understanding of both GBM tumor biology and the mechanisms underlying the acquirement of treatment resistance in recurrent GBMs. A comprehensive understanding of these markers is mandatory for the development of treatments against therapy-resistant GBMs...
June 14, 2018: International Journal of Molecular Sciences
Ji-Wei Ma, Xiao Wang, Lei Chang, Xue-Yun Zhong, Haiyan Jing, Xiaolong Zhu, Shaoxiang Wang, WeiWei Xiao
CD44, a glycoprotein, has been reported to have relationship with resistance to radiation in prostate cancer (Cap) cells. However, its molecular mechanism remains unknown. In this study, we demonstrated that inhibited CD44 enhanced the radiosentivity in Cap cells. It has been hypothesized that CD44 combine with ERBB2 and activate downstream phosphated protein to mediate DNA damage repair. Therefore, we conducted a detailed analysis of effects of radiation by clonogenic assay and immunofluorescence stain for p-H2AX foci...
June 9, 2018: Experimental Cell Research
Julian Hlouschek, Christine Hansel, Verena Jendrossek, Johann Matschke
Pronounced resistance of lung cancer cells to radiotherapy and chemotherapy is a major barrier to successful treatment. Herein, both tumor hypoxia and the upregulation of the cellular antioxidant defense systems observed during malignant progression can contribute to radioresistance. We recently found that exposure to chronic cycling severe hypoxia/reoxygenation stress results in glutamine-dependent upregulation of cellular glutathione (GSH) levels and associated radiation resistance opening novel routes for tumor cell-specific radiosensitization...
2018: Frontiers in Oncology
Xu Chen, Lei Wu, Dezhi Li, Yanmei Xu, Luping Zhang, Kai Niu, Rui Kong, Jiaoyang Gu, Zihan Xu, Zhengtang Chen, Jianguo Sun
Lung cancer is one of the main causes of cancer mortality globally. Most patients received radiotherapy during the course of disease. However, radioresistance generally occurs in the majority of these patients, leading to poor curative effect, and the underlying mechanism remains unclear. In the present study, miR-18a-5p expression was downregulated in irradiated lung cancer cells. Overexpression of miR-18a-5p increased the radiosensitivity of lung cancer cells and inhibited the growth of A549 xenografts after radiation exposure...
June 2, 2018: Cancer Medicine
Christianne Hoey, Jessica Ray, Jouhyun Jeon, Xiaoyong Huang, Samira Taeb, Jarkko Ylanko, David W Andrews, Paul C Boutros, Stanley K Liu
Recurrence of high-grade prostate cancer after radiotherapy is a significant clinical problem, resulting in increased morbidity and reduced patient survival. The molecular mechanisms of radiation resistance are being elucidated through the study of microRNAs (miR) that negatively regulate gene expression. We performed bioinformatics analyses of The Cancer Genome Atlas (TCGA) dataset to evaluate the association of miR-106a and its putative target lipopolysaccharide-induced TNF- α factor (LITAF) in prostate cancer...
May 30, 2018: Molecular Oncology
P Ahmad, M Slavík, J Šána, M Hermanová, P Šlampa, P Smilek, T Kazda, O Slabý
BACKGROUND: Radiotherapy plays a key role in the treatment of squamous cell head and neck cancers (HNSCC). The effectivity of radiation therapy is often limited by radioresistance of these tumours. microRNAs (miRNAs) are endogenous, evolutionary conserved, small non-coding RNAs involved in regulation of cellular processes associated with radioresistance. The objective of this study was to identify miRNA profile enabling to predict the radiation treatment outcomes in HNSCC patients. MATERIAL AND METHODS: The retrospective study included HNSCC patients who underwent a definitive radiotherapy...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Julie Konge, François Leteurtre, Maud Goislard, Denis Biard, Sandrine Morel-Altmeyer, Aurélie Vaurijoux, Gaetan Gruel, Sylvie Chevillard, Jérôme Lebeau
Failure of conventional antitumor therapy is commonly associated with cancer stem cells (CSCs), which are often defined as inherently resistant to radiation and chemotherapeutic agents. However, controversy about the mechanisms involved in the radiation response remains and the inherent intrinsic radioresistance of CSCs has also been questioned. These discrepancies observed in the literature are strongly associated with the cell models used. In order to clarify these contradictory observations, we studied the radiosensitivity of breast CSCs using purified CD24-/low /CD44+ CSCs and their corresponding CD24+ /CD44low non-stem cells...
May 4, 2018: Oncotarget
Chao Liu, Ligang Wang, Hongmei Qiu, Qing Dong, Yong Feng, Dawei Li, Chengli Li, Cundong Fan
Radioactive 125 I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mechanism remains elusive. Herein, in the present study, a combined chemoradiation model of 125 I seeds and salinomycin (SAL) in vitro and in vivo was designed, and the enhanced anticancer efficiency and mechanism were also evaluated in human glioma...
May 26, 2018: Neurochemical Research
Ali Yadollahpour, Zohre Rezaee, Vahid Bayati, Mohammad Javad Tahmasebi Birgani, Fereshteh Negad Dehbashi
Background: The efficiency of radiotherapy for tumors can be enhanced with different radiosensitizers. Previous studies have shown that electroporation (EP) can sensitize some cancer cell lines to ionizing radiation (IR). HT-29 is a radiation resistant colorectal cancer cell line, representative of a cancer type which is the second cause of cancer mortalities in developed countries. The present study aimed to evaluate radiosensitizing effects of EP on HT-29 cells in vitro exposed to 6 MV X-ray photon beams...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Hengyi Fan, Raorao Yuan, Shiqi Cheng, Kun Xiong, Xingen Zhu, Yan Zhang
BACKGROUND: Glioma is the most common cause of cancer-related death. Therapy based on radiation seemed to effectively, while the radioresistance of several glioblastoma cells abolished the therapy. Thus, to employ the potential mechanism underlying the radioresistance is essential for glioma treatment. METHODS: Radioresistant cells were constructed using the X-ray radiation. Cell viability and apoptosis were detect using CCK-8 and Annexin-V/propidium iodide (PI), respectively...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jintaek Im, Jessica Lawrence, Davis Seelig, Richard S Nho
Radiation therapy is critical for the control of many tumors and lung is an important dose-limiting organ that impacts radiation dose prescribed to avoid irreversible pulmonary fibrosis in cancer survivors. Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible lung disease caused by aberrantly activated lung (myo)fibroblasts. The presence of pro-fibrotic, apoptosis-resistant fibroblasts in IPF promotes progressive fibrosis and may have a role in other diseases, if these resistant cells are selected for as a consequence of treatment...
May 22, 2018: Cell Death & Disease
Amir Abbas Momtazi, Faezeh Ghasemi, Amirreza Hesari, Muhammed Majeed, Michele Caraglia, Amirhossein Sahebkar
Nasopharyngeal cancer (NPC) is a rare type of head and neck cancer that is mainly treated by radiotherapy, but sometimes it is radioresistant. Curcumin is a polyphenolic natural product with established anti-cancer effects in various human cancers. Recent studies have shown that curcumin has therapeutic and radio-sensitizing effects on NPC cells. In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs...
May 21, 2018: Current Pharmaceutical Design
Bum-Sup Jang, In Ah Kim
PURPOSE: Identifying predictive factors for the clinical outcome of patients with lower grade gliomas following radiotherapy could help optimize patient treatments. Here, we investigate the predictive efficacy of both a previously identified "31-gene signature" and programmed death ligand-1 (PD-L1) expression. MATERIAL AND METHODS: We identified 511 patients with lower grade glioma (Grade 2 and 3) in The Cancer Genome Atlas dataset and divided them into two clusters: radiosensitive (RS) and radioresistant (RR)...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Diaz-Feijoo Berta, Luna-Guibourg Rocio, Cabrera Silvia, Manrique Susana, Gil-Moreno Antonio
OBJECTIVE: To demonstrate the feasibility of laparoscopic extraperitoneal approach for pelvic metastatic lymph node debulking in locally advanced cervical cancer. DESIGN: Surgical video article. Canadian task force Classification III. SETTING: University Hospital PATIENT: A 52 year-old patient presented a stage IIA2 Cervical adenocarcinoma according to FIGO classification. The physical exam reported a 45 mm tumor. Positron emission tomography (PET- CT) was positive for hypermetabolic enlarged lymph nodes in left external iliac region of 1...
May 18, 2018: Journal of Minimally Invasive Gynecology
Hanumappa Ananda, Kothanahally S Sharath Kumar, Muddenahalli S Sudhanva, Shobith Rangappa, Kanchugarakoppal S Rangappa
Aberrant expression of estrogen receptor alpha (ER-α) is observed in many pathological complications like breast cancer, endometrial cancer, and in osteoporosis. ER-α plays a vital role in the initiation and progression of breast cancer and confers chemo and radioresistance to the cancer cells by upregulating expression of anti-apoptotic proteins. The synthetic pyrazole derivative 3-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl)pyridine (compound 5d) displays significant cytotoxicity against mammary carcinoma cells...
May 18, 2018: Molecular and Cellular Biochemistry
Ayman J Oweida, Andy Phan, Benjamin Vancourt, Tyler Robin, Mohammad K Hararah, Shilpa Bhatia, Dallin Milner, Shelby Lennon, Laura Pike, David Raben, Bryan R Haugen, Nikita Pozdeyev, Rebecca E Schweppe, Sana D Karam
Anaplastic thyroid cancer is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment including radiation therapy and chemotherapy, response rates remain below 15% with a median time to progression of less than 3 months. Recent advances in radiotherapy delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative radiotherapy fractionation schedules for overcoming radioresistance...
May 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Yanmei Zou, Shuo Yao, Xiuqiong Chen, Dian Liu, Jianhua Wang, Xun Yuan, Jie Rao, Huihua Xiong, Shiying Yu, Xianglin Yuan, Feng Zhu, Guohong Hu, Yihua Wang, Hua Xiong
OBJECT: This study aimed to investigate the role of lncRNA OIP5-AS1 in regulating radioresistance of colorectal cancer (CRC) cells. METHODS: Microarray analysis was used to screen out lncRNAs differentially expressed in radio-resistant CRC cell lines. Expression levels of OIP5-AS1, miR-369-3p and DYRK1A in CRC cell lines were measured by qRT-PCR. Protein expression of DYRK1A was determined by western blot. The target relationships among OIP5-AS1, miR-369-3p and DYRK1A were validated by dual luciferase reporter assay...
April 14, 2018: European Journal of Cell Biology
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