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Cancer and radioresistance

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https://www.readbyqxmd.com/read/29679028/radiosensitization-by-marine-sponge-agelas-sp-extracts-in-hepatocellular-carcinoma-cells-with-autophagy-induction
#1
Changhoon Choi, Arang Son, Hyi-Seung Lee, Yeon-Ju Lee, Hee Chul Park
Although radiation therapy is an effective treatment modality in many cancers, there is an urgent need to develop therapeutic drugs capable of overcoming radioresistance or minimizing normal tissue toxicity. A wide variety of marine-derived bioactive compounds have been screened for anti-cancer drug discovery, but little is known regarding radiation therapy applications. In this study, six different extracts of marine sponges collected from the Micronesian sea were screened for anti-cancer and radiosensitizing activity...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678527/the-effect-of-neoadjuvant-androgen-deprivation-therapy-on-tumor-hypoxia-in-high-grade-prostate-cancer-an-18-f-miso-pet-mri-study
#2
Ismini C Mainta, Thomas Zilli, Jean-Christophe Tille, Thomas De Perrot, Jean-Paul Vallée, Franz Buchegger, Valentina Garibotto, Raymond Miralbell
PURPOSE: Tumor hypoxia is associated with radioresistance and poor prognosis after radiation therapy for prostate cancer (PCa). In this prospective pilot study, we assessed the ability of 18 F-misonidazole (18 F-MISO) positron emission tomography (PET)-magnetic resonance imaging (MRI) to detect hypoxia in high-grade PCa patients who were candidates for curative radiation therapy, and we evaluated 18 F-MISO PET-MRI modulation after 3 months of neoadjuvant androgen deprivation therapy (nADT)...
March 8, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29665670/-the-relationship-between-the-radioresistance-of-pancreatic-cancer-cell-sw1990-and-the-induction-of-the-epithelial-mesenchymal-transition-an-in-vitro-study
#3
Y H Jiang, K Y You, Z F Bi, L T Li, H Q Mo, Y M Liu
Objective: To investigate the relationship between the radioresistance of pancreatic cancer cell SW1990 and the induction of the Epithelial-Mesenchymal Transition (EMT). Methods: The radio-resistant pancreatic cancer cell SW1990-R were established by using the method of radiating pancreatic cancer cell SW1990 step by step and repeatedly. Then the changes of the morphology of the cell was observed by inverted phase contrast microscope, the radioresistance of SW1990-R was detected by colony-forming assay, and the apoptosis rate of the two cell lines after radiation were measured by flow cytometry...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29661777/interferon-stimulated-genes-are-involved-in-cross-resistance-to-radiotherapy-in-tamoxifen-resistant-breast-cancer
#4
Annemarie E M Post, Marcel Smid, Anika Nagelkerke, John W M Martens, Johan Bussink, Fred Cjg Sweep, Paul N Span
PURPOSE: Treatment resistance is a main cause of adverse disease outcome in breast cancer patients. Here we aimed to investigate common features in tamoxifen-resistant and radioresistant breast cancer, since tamoxifen-resistant breast cancer cells are cross-resistant to irradiation in vitro. EXPERIMENTAL DESIGN: RNA sequencing of tamoxifen-resistant and radioresistant breast cancer cells was performed and validated by quantitative PCR. Pathways were further investigated in vitro and in breast cancer patient cohorts to establish their relation with treatment resistance...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29658569/%C3%AE-%C3%A2-catenin-nuclear-translocation-induced-by-hif%C3%A2-1%C3%AE-overexpression-leads-to-the-radioresistance-of-prostate-cancer
#5
Yong Luo, Mingchuan Li, Xuemei Zuo, Spyridon P Basourakos, Jiao Zhang, Jiahui Zhao, Yili Han, Yunhua Lin, Yongxing Wang, Yongguang Jiang, Ling Lan
Hypoxia-inducible factor‑1α (HIF‑1α) is known to play crucial roles in tumor radioresistance; however, the molecular mechanisms responsible for the promotion of tumor radioresistance by HIF‑1α remain unclear. β‑catenin is known to be involved in the metastatic potential of prostate cancer (PCa). In this study, to investigate the role of HIF‑1α and β‑catenin in the radioresistance of PCa, two PCa cell lines, LNCaP and C4‑2B, were grouped as follows: Negative control (no treatment), HIF‑1α overexpression group (transfected with HIF‑1α overexpression plasmid) and β‑catenin silenced group (transfected with HIF‑1α plasmids and β‑catenin-shRNA)...
April 12, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29653204/epha3-maintains-radioresistance-in-head-and-neck-cancers-through-epithelial-mesenchymal-transition
#6
Song Hee Kim, Won Hyeok Lee, Seong Who Kim, Je Hyoung Uk, Jong Cheol Lee, Hyo Won Chang, Young Min Kim, Kyungbin Kim, Sang Yoon Kim, Myung Woul Han
Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers. Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear...
April 10, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29652830/colorectal-cancer-genetic-abnormalities-tumor-progression-tumor-heterogeneity-clonal-evolution-and-tumor-initiating-cells
#7
REVIEW
Ugo Testa, Elvira Pelosi, Germana Castelli
Colon cancer is the third most common cancer worldwide. Most colorectal cancer occurrences are sporadic, not related to genetic predisposition or family history; however, 20-30% of patients with colorectal cancer have a family history of colorectal cancer and 5% of these tumors arise in the setting of a Mendelian inheritance syndrome. In many patients, the development of a colorectal cancer is preceded by a benign neoplastic lesion: either an adenomatous polyp or a serrated polyp. Studies carried out in the last years have characterized the main molecular alterations occurring in colorectal cancers, showing that the tumor of each patient displays from two to eight driver mutations...
April 13, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29650272/treatment-of-spinal-metastases-in-renal-cell-carcinoma-a-critical-review
#8
REVIEW
Diego Teyssonneau, Marine Gross-Goupil, Charlotte Domblides, Thibaud Haaser, Vincent Pointillart, Amaury Daste, Olivier Hauger, Alain Ravaud
Kidney cancer is the 9th most common cancer in men and the 14th most common in women worldwide. Renal cell carcinoma (RCC) constitutes 90% of all malignancies of the kidney. RCC, is known to be highly vascular and relatively radioresistant. Bone metastases are one of the most common metastatic sites and occur in around 30% of RCCs. They significantly impact the quality of life of patients causing pain and pathological fractures. Spinal metastases represent a particular case with regard to symptoms and treatment...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29644941/role-of-micrornas-in-treatment-response-in-prostate-cancer
#9
Anshuli Razdan, Paul de Souza, Tara Laurie Roberts
Prostate cancer (PCa) is the most common non-skin cancer in men worldwide, resulting in significant mortality and morbidity. Depending on the grade and stage of the cancer, patients may be given radiation therapy, hormonal therapy, or chemotherapy. However, more than half these patients develop resistance to treatment, leading to disease progression and metastases, often with lethal consequences. MicroRNAs (miRNAs) are short, non-coding RNAs, which regulate numerous physiological as well as pathological processes, including cancer...
March 15, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29626227/effect-of-internal-contamination-with-tritiated-water-on-the-neoplastic-colonies-in-the-lungs-innate-anti-tumour-reactions-cytokine-profile-and-haematopoietic-system-in-radioresistant-and-radiosensitive-mice
#10
Ewa M Nowosielska, Aneta Cheda, Robert Zdanowski, Sławomir Lewicki, Bobby R Scott, Marek K Janiak
Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low (0.01 or 0.1 Gy) and intermediate (1.0 Gy) cumulative whole-body doses of β radiation is immunosuppressive, as judged by enhancement of artificial tumour metastases, functioning of NK lymphocytes and macrophages, circulating cytokine's levels, and numbers of bone marrow, spleen, and peripheral blood cells...
April 6, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29620203/inhibition-of-dna%C3%A2-pk-activity-sensitizes-a549-cells-to-x%C3%A2-ray-irradiation-by-inducing-the-atm%C3%A2-dependent-dna-damage-response
#11
Lina Yang, Xinrui Yang, Yiwei Tang, Defu Zhang, Lijie Zhu, Shengnan Wang, Bo Wang, Tao Ma
Non‑small cell lung cancer (NSCLC) is radioresistant to X‑rays due to powerful cellular DNA damage repair mechanisms. DNA‑dependent protein kinase (DNA‑PK) is a key enzyme involved in DNA damage repair and the phenomenon and molecular mechanism of NSCLC radionsensitivity were investigated following inhibition of DNA‑PK activity. In the present study A549 cells were treated with the DNA‑PK inhibitor NU7026 and/or siRNA directed against ataxia telangiectasia mutated (ATM), followed by exposure to 4 Gy X‑ray irradiation...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29616037/microrna-roles-in-the-nuclear-factor-kappa-b-signaling-pathway-in-cancer
#12
REVIEW
Jin'en Wu, Juntao Ding, Jing Yang, Xiaola Guo, Yadong Zheng
Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that orchestrates various physiological and pathological processes, especially cell proliferation, inflammation, and cancer development and progression. NF-κB expression is transient and tightly regulated in normal cells, but it is activated in cancer cells. Recently, numerous studies have demonstrated microRNAs (miRNAs) play a vital role in the NF-κB signaling pathway and NF-κB-associated immune responses, radioresistance and drug resistance of cancer, some acting as inhibitors and the others as activators...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29614485/mir-99a-enhances-the-radiation-sensitivity-of-non-small-cell-lung-cancer-by-targeting-mtor
#13
Hang Yin, Jianqun Ma, Lin Chen, Shiqi Piao, Yu Zhang, Siliang Zhang, Hongyu Ma, Yang Li, Yuanyuan Qu, Xiaoyuan Wang, Qingyong Xu
BACKGROUND/AIMS: Radiation therapy is an important and effective modality for the treatment of non-small cell lung cancer (NSCLC). MicroRNAs (miRNAs) are crucial post-transcriptional regulators that are involved in numerous important biologic processes. However, their potential involvement in radiation sensitivity remains unknown. MATERIALS: We performed integrated analysis of miRNA expression in NSCLC using The Cancer Genome Atlas datasets. miR-99a was found to be significantly upregulated in cancer tissue and regulated cell survival...
March 26, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29611723/activation-of-tumor-cell-integrin-%C3%AE-v%C3%AE-3-by-radiation-and-reversal-of-activation-by-chemically-modified-tetraiodothyroacetic-acid-tetrac
#14
John T Leith, Aleck Hercbergs, Susan Kenney, Shaker A Mousa, Paul J Davis
PURPOSE: Integrin αvβ3 is an important structural and signaling protein of the plasma membrane of cancer cells and dividing blood vessel cells. The plastic extracellular domain of the protein binds to extracellular matrix proteins and plasma membrane proteins, changing cell-cell interactions and generating intracellular signals that influence cell behavior. αvβ3 also contains a receptor for thyroid hormone and derivatives, including tetraiodothyroacetic acid (tetrac). MATERIALS AND METHODS: Human prostate cancer (PC3) cells were engrafted in the chicken chorioallantoic membrane model...
April 3, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29602802/smad4-gene-mutation-renders-pancreatic-cancer-resistance-to-radiotherapy-through-promotion-of-autophagy
#15
Feng Wang, Xiaojun Xia, Chunying Yang, Jianliang Shen, Junhua Mai, Han-Cheon Kim, Dickson Kirui, Ya'an Kang, Jason B Fleming, Eugene J Koay, Sankar Mitra, Mauro Ferrari, Haifa Shen
PURPOSE: Understanding the mechanism of radioresistance could help develop strategies to improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently mutated in pancreatic cancer. In this study, we investigated the role of SMAD4 deficiency in pancreatic cancer cells' response to radiotherapy. EXPERIMENTAL DESIGN: We downregulated SMAD4 expression with SMAD4 siRNA or SMAD4 shRNA and overexpressed SMAD4 in SMAD4 mutant pancreatic cancer cells followed by clonogenic survival assay to evaluate their effects on cell radioresistance...
March 30, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29602129/sanyang-xuedai-enhances-the-radiosensitivity-of-human-non-small-cell-lung-cancer-cells-via-increasing-inos-no-production
#16
Li Wang, Yaoxiong Xia, Ting Chen, Yueqin Zeng, Lan Li, Yu Hou, Wenhui Li, Zhijie Liu
OBJECTIVE: In this research, we aimed at finding out how San Yang Xue Dai (SYKT) promotes the radiosensitivity of non-small cell lung cancer (NSCLC) cell line NCI-H460. METHODS: Survival rate of NSCLC cells (A549, NCI-H460, NCI-H1650 and NCI-H1975) after the SYKT treatment or irradiation (IR) was calculated by the MTT assay. The radiosensitization of SYKT (0.5 g/mL and 1.0 g/mL) on cell line NCI-H460 and the radioresistant cell line NCI-H460R was studied by MTT assay and clone formation assay...
March 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29597090/lobaplatin-promotes-radiosensitivity-induces-apoptosis-attenuates-cancer-stemness-and-inhibits-proliferation-through-pi3k-akt-pathway-in-esophageal-squamous-cell-carcinoma
#17
Shupei Pan, Yuchen Sun, Donghu Sui, Tian Yang, Shenbo Fu, Jizhao Wang, Beina Hui, Ruxing Xi, Chenchen He, Xiaozhi Zhang
Radiotherapy is one of the common treatments for esophageal squamous cell carcinoma (ESCC). Yet, local recurrence led by radioresistance is still not solved. Lobaplatin (LBP) is known to have powerful clinical anti-tumor activities in various tumors, but its effect in radiotherapy is rarely studied. Here we report that LBP is a promising radiosensitizer for ESCC. We treated ESCC cells with LBP and radiation, both separately and in combination. Untreated cells were set as control groups. We found that LBP inhibited ESCC cell growth and enhanced their radiosensitivity...
March 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29594243/resolution-of-atelectasis-during-radiochemotherapy-of-lung-cancer-with-serious-implications-for-further-treatment-a-case-report
#18
Lore Helene Braun, Stefan Welz, Marén Viehrig, Frank Heinzelmann, Daniel Zips, Cihan Gani
Local failure is a major cause for low overall survival rates in advanced non small cell lung cancer (NSCLC). Among others, radioresistant tumor clones as well as geographical miss can explain these high local failure rates. One reason for geographical miss is a change of tumor related atelectasis in the course of radiotherapy. We present the case of a patient with UICC Stage IIIb NSCLC who presented with a large tumor related atelectasis. During definitive radiochemotherapy, the atelectasis resolved, which resulted in a massive tumor shift out of the planning target volume within 2 days...
February 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594218/the-predictive-value-of-nadir-neutrophil-count-during-treatment-of-cervical-cancer-interactions-with-tumor-hypoxia-and-interstitial-fluid-pressure-ifp
#19
Rachel Glicksman, Naz Chaudary, Melania Pintilie, Eric Leung, Blaise Clarke, Kieyan Sy, Richard P Hill, Kathy Han, Anthony Fyles, Michael Milosevic
Background and purpose: Hypoxia, high interstitial fluid pressure (IFP) and immune effects have individually been shown to modulate radiotherapy (RT) response in cervical cancer. The aim of this study was to investigate the interplay between hypoxia or IFP and circulating neutrophil levels, and their combined effect on survival following RT. Material and methods: A total of 287 FIGO stage IB to IIIB cervical cancer patients treated with RT or RT and cisplatin (RTCT) were included...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29590676/radiotoxicity-of-alpha-particles-versus-high-and-low-energy-electrons-in-hypoxic-cancer-cells
#20
Ute Maucksch, Roswitha Runge, Liane Oehme, Jörg Kotzerke, Robert Freudenberg
PURPOSE: Hypoxic regions of tumors are less sensitive to radio- and chemotherapy, leading to poor prognosis of patients. One option to overcome the radioresistance is the irradiation of hypoxic tumors with high linear energy transfer (LET) α- or Auger electronemitters assuming their radiotoxicity would be less dependent on the cellular oxygenation status. Therefore, the aim of the present study was to determine whether irradiation with the intracellularly distributed Auger electron/γ-emitter99m Tc using the tracer [99m Tc]TcHMPAO is a promising therapeutic option for the treatment of hypoxic tumor cells...
April 2018: Nuklearmedizin. Nuclear Medicine
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