Jianghua Li, Kaixi Zhang, Lin Ruan, Seow Fong Chin, Nirmani Wickramasinghe, Hanbin Liu, Vikashini Ravikumar, Jinghua Ren, Hongwei Duan, Liang Yang, Mary B Chan-Park
Biofilms and the rapid evolution of multidrug resistance complicate the treatment of bacterial infections. Antibiofilm agents such as metallic-inorganic nanoparticles or peptides act by exerting antibacterial effects and, hence, do not combat biofilms of antibiotics-resistant strains. In this Letter, we show that the block copolymer DA95B5, dextran- block-poly((3-acrylamidopropyl) trimethylammonium chloride (AMPTMA)- co-butyl methacrylate (BMA)), effectively removes preformed biofilms of various clinically relevant multidrug-resistant Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE V583), and Enteroccocus faecalis (OG1RF)...
July 11, 2018: Nano Letters